Jyoti Chattopadhyaya

Synthetic siRNA targeting human papillomavirus 16 E6: a perspective on in vitro nanotherapeutic approaches

Togtema, Melissa; Jackson, Robert; Grochowski, Jessica; Villa, Peter L. et al.

Ingår i Nanomedicine, s. 455-474, 2018

• DOI för Synthetic siRNA targeting human papillomavirus 16 E6: a perspective on in vitro nanotherapeutic approaches

C2 '-F Stereoconfiguration As a Puckering Switch for Base Stacking at the Dinucleotide Level

Moriou, Céline; Da Silva, Adilson D.; Vianelli Prado, Marcos Joel; Denhez, Clément et al.

Ingår i Journal of Organic Chemistry, s. 2473-2478, 2018

• DOI för C2 '-F Stereoconfiguration As a Puckering Switch for Base Stacking at the Dinucleotide Level

How RNase HI (Escherichia coli) promoted site-selective hydrolysis works on RNA in duplex with carba-LNA and LNA substituted antisense strands in an antisense strategy context?

Plashkevych, Oleksandr; Li, Qing; Chattopadhyaya, Jyoti

Ingår i Molecular Biosystems, s. 921-938, 2017

• DOI för How RNase HI (Escherichia coli) promoted site-selective hydrolysis works on RNA in duplex with carba-LNA and LNA substituted antisense strands in an antisense strategy context?

A Minute Amount of S-Puckered Sugars Is Sufficient for (6-4) Photoproduct Formation at the Dinucleotide Level

Moriou, Celine; Denhez, Clement; Plashkeyych, Oleksandr; Coantic-Castex, Stephanie et al.

Ingår i Journal of Organic Chemistry, s. 615-619, 2015

• DOI för A Minute Amount of S-Puckered Sugars Is Sufficient for (6-4) Photoproduct Formation at the Dinucleotide Level

Distal Two-Bond versus Three-Bond Electronegative Oxo-Substituent Effect Controls the Kinetics and Thermodynamics of the Conversion of a C-Nitroso Function to the Corresponding Oxime in the Conformationally Locked Pentofuranose (Bicyclo[2.2.1]heptane) System

Karimiahmadabadi, Mansoureh; Erfan, Sayeh; Földesi, András; Chattopadhyaya, Jyoti

Ingår i Journal of Organic Chemistry, s. 7266-7276, 2014

• DOI för Distal Two-Bond versus Three-Bond Electronegative Oxo-Substituent Effect Controls the Kinetics and Thermodynamics of the Conversion of a C-Nitroso Function to the Corresponding Oxime in the Conformationally Locked Pentofuranose (Bicyclo[2.2.1]heptane) System

New antiprotozoal agents: Their synthesis and biological evaluations

Upadhayaya, Ram Shankar; Dixit, Shailesh S.; Földesi, András; Chattopadhyaya, Jyoti

Ingår i Bioorganic & Medicinal Chemistry Letters, s. 2750-2758, 2013

• DOI för New antiprotozoal agents: Their synthesis and biological evaluations

Intramolecular Free-Radical Cyclization Reactions on Pentose Sugars for the Synthesis of Carba-LNA and Carba-ENA and the Application of Their Modified Oligonucleotides as Potential RNA Targeted Therapeutics

Zhou, Chuanzheng; Chattopadhyaya, Jyoti

Ingår i Chemical Reviews, s. 3808-3832, 2012

• DOI för Intramolecular Free-Radical Cyclization Reactions on Pentose Sugars for the Synthesis of Carba-LNA and Carba-ENA and the Application of Their Modified Oligonucleotides as Potential RNA Targeted Therapeutics

Steric Effects in the Tuning of the Diastereoselectivity of the Intramolecular Free-Radical Cyclization to an Olefin As Exemplified through the Synthesis of a Carba-Pentofuranose Scaffold

Karimi, Mansoureh; Erfan, Sayeh; Földesi, András; Chattopadhyaya, Jyoti

Ingår i Journal of Organic Chemistry, s. 6855-6872, 2012

• DOI för Steric Effects in the Tuning of the Diastereoselectivity of the Intramolecular Free-Radical Cyclization to an Olefin As Exemplified through the Synthesis of a Carba-Pentofuranose Scaffold

Unusual strain-releasing nucleophilic rearrangement of a bicyclo[2.2.1]heptane system to a cyclohexenyl derivative

Karimiahmadabadi, Mansoureh; Földesi, András; Chattopadhyaya, Jyoti

Ingår i Journal of Organic Chemistry, s. 9747-9755, 2012

• DOI för Unusual strain-releasing nucleophilic rearrangement of a bicyclo[2.2.1]heptane system to a cyclohexenyl derivative

New parasite inhibitors encompassing novel conformationally-locked 5 '-acyl sulfamoyl adenosines

Dixit, Shailesh S.; Upadhayaya, Ram Shankar; Chattopadhyaya, Jyoti

Ingår i Organic and biomolecular chemistry, s. 6121-6129, 2012

• DOI för New parasite inhibitors encompassing novel conformationally-locked 5 '-acyl sulfamoyl adenosines

Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs

Hu, Jiaxin; Gagnon, Keith T.; Liu, Jing; Watts, Jonathan K. et al.

Ingår i Biological chemistry (Print), s. 315-325, 2011

• DOI för Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs

Carba-LNA-^5MeC/A/G/T Modified Oligos Show Nucleobase-Specific Modulation of 3′-Exonuclease Activity, Thermodynamic Stability, RNA Selectivity, and RNase H Elicitation: Synthesis and Biochemistry

Upadhayaya, RamShankar; Deshpande, Sachin Gangadhar; Li, Qing; Kardile, Ramakant Asaram et al.

Ingår i Journal of Organic Chemistry, s. 4408-4431, 2011

• DOI för Carba-LNA-^5MeC/A/G/T Modified Oligos Show Nucleobase-Specific Modulation of 3′-Exonuclease Activity, Thermodynamic Stability, RNA Selectivity, and RNase H Elicitation: Synthesis and Biochemistry

The R-diastereomer of 6 '-O-toluoyl-carba-LNA modification in the core region of siRNA leads to 24-times improved RNA silencing potency against the HIV-1 compared to its S-counterpart

Dutta, Suman; Bhaduri, Nipa; Upadhayaya, Ram Shankar; Rastogi, Neha et al.

Ingår i MedChemComm, s. 1110-1119, 2011

• DOI för The R-diastereomer of 6 '-O-toluoyl-carba-LNA modification in the core region of siRNA leads to 24-times improved RNA silencing potency against the HIV-1 compared to its S-counterpart

Molecular Structure of the Core-Modified siRNA Duplexes Containing Diastereomeric Pair of [C6′(R)-OH]- versus [C6′(S)-OH]-carba-LNAs Suggests a Model for RNAi Action

Plashkevych, Oleksandr; Chattopadhyaya, Jyoti

Ingår i Nucleosides, Nucleotides & Nucleic Acids, s. 815-825, 2011

• DOI för Molecular Structure of the Core-Modified siRNA Duplexes Containing Diastereomeric Pair of [C6′(R)-OH]- versus [C6′(S)-OH]-carba-LNAs Suggests a Model for RNAi Action

Carba-LNA modified siRNAs targeting HIV-1 TAR region downregulate HIV-1 replication successfully with enhanced potency

Dutta, Suman; Bhaduri, Nipa; Rastogi, Neha; Chandel, Sunita G. et al.

Ingår i MedChemComm, s. 206-216, 2011

• DOI för Carba-LNA modified siRNAs targeting HIV-1 TAR region downregulate HIV-1 replication successfully with enhanced potency

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

Bramsen, Jesper B.; Laursen, Maria B; Nielsen, Anne F.; Hansen, Thomas B. et al.

Ingår i Nucleic Acids Research, s. 2867-2881, 2009

• DOI för A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

High-quality oligo-RNA synthesis using the new 2′-O-TEM protecting group by selectively quenching the addition of p-tolyl vinyl sulphone to exocyclic amino functions

Zhou, Chuanzheng; Pathmasiri, Wimal; Honcharenko, Dmytro; Chatterjee, Subhrangsu et al.

Ingår i Canadian journal of chemistry (Print), s. 293-301, 2007

• DOI för High-quality oligo-RNA synthesis using the new 2′-O-TEM protecting group by selectively quenching the addition of p-tolyl vinyl sulphone to exocyclic amino functions

Interactions of drugs and an oligonucleotide with charged membranes analyzed by immobilized liposome chromatography

Lundquist, Anna; Engvall, Caroline; Boija, Elisabet; Kurtovic, Sanela et al.

Ingår i Biomedical Chromatography, s. 83-87, 2006

• DOI för Interactions of drugs and an oligonucleotide with charged membranes analyzed by immobilized liposome chromatography

Non-identical electronic characters of the internucleotidic phosphates in RNA modulate the chemical reactivity of the phosphodiester bonds.

Barman, Jharna; Acharya, Sandipta; Zhou, Chuanzheng; Chatterjee, Subhrangsu et al.

Ingår i Org Biomol Chem, s. 928-41, 2006

Oxetane locked thymidine in the Dickerson-Drew dodecamer causes local base pairing distortions: an NMR structure and hydration study

Isaksson, Johan; Plashkevych, Oleksandr; Pradeepkumar, P. I.; Chatterjee, Subhrangsu et al.

Ingår i Journal of Biomolecular Structure and Dynamics, s. 299-330, 2005

• DOI för Oxetane locked thymidine in the Dickerson-Drew dodecamer causes local base pairing distortions: an NMR structure and hydration study

A uniform mechanism correlating dangling-end stabilization and stacking geometry.

Isaksson, J; Chattopadhyaya, J

Ingår i Biochemistry, s. 5390-401, 2005

Electrostatic Cross-modulation of the Pseudoaromatic Character in Single Stranded RNA by Nearest-neighbor interactions

Acharya, P; Chattopadhyaya, J

Ingår i Pure and Applied Chemistry, s. 291-311, 2005

2'/3'-O-peptidyl Adenosine as a General Base Catalyst of its Own External Peptidyl Transfer: Implications for the Ribosome Catalytic Mechanism.

Changalov, M M; Ivanova, G D; Rangelov, M A; Acharya, P et al.

Ingår i Chembiochem, s. 992-996, 2005

Significant pKa perturbation of nucleobases is an intrinsic property of the sequence context in DNA and RNA.

Acharya, Sandipta; Barman, Jharna; Cheruku, Pradeep; Chatterjee, Subhrangsu et al.

Ingår i J Am Chem Soc, s. 8674-81, 2004

Single-stranded adenine-rich DNA and RNA retain structural characteristics of their respective double-stranded conformations and show directional differences in stacking pattern.

Isaksson, J; Acharya, S; Barman, J; Cheruku, P et al.

Ingår i Biochemistry, s. 15996-6010, 2004

Oxetane modified, conformationally constrained, antisense oligodeoxyribonucleotides function efficiently as gene silencing molecules.

Opalinska, J B; Kalota, A; Gifford, Lida K; Lu, Ponzy et al.

Ingår i Nucleic Acids Res, s. 5791-9, 2004

Book Review on "Highlights in Bioorganic Chemistry"

Chattopadhyaya, J

Ingår i ChemBioChem, s. 1719, 2004

Measurement of nucleobase pKa values in model mononucleotides shows RNA-RNA duplexes to be more stable than DNA-DNA duplexes.

Acharya, P; Cheruku, P; Chatterjee, S; Acharya, S et al.

Ingår i J Am Chem Soc, s. 2862-9, 2004

Synthesis of 2'-2H1-Ribonucleosides

Földesi, A; Kundu, M K; Dinya, Z; Chattopadhyaya, J

Ingår i Helvetica Chemica Acta, s. 742-757, 2004

Synthesis, physicochemical and biochemical studies of 1',2'-oxetane constrained adenosine and guanosine modified oligonucleotides, and their comparison with those of the corresponding cytidine and thymidine analogues.

Pradeepkumar, Pushpangadan I; Cheruku, Pradeep; Plashkevych, Oleksandr; Acharya, Parag et al.

Ingår i J Am Chem Soc, s. 11484-99, 2004

Human deoxycytidine kinase as a deoxyribonucleoside phosphorylase.

Usova, Elena; Maltseva, Tatiana; Földesi, Andras; Chattopadhyaya, Jyoti et al.

Ingår i J Mol Biol, s. 1347-58, 2004

Modified Nucleosides and Nucleotides and Their Use Thereof.

Chattopadhyaya, J

2004

Studies on the Stereoselective Synthesis of Deuterated- Ribose Derivatives

Kundu, M K; Földesi, A; Chattopadhyaya, J

Ingår i Helvetica Chemica Acta, s. 633-643, 2003

A repertoire of pyridinium-phenyl-methyl cross-talk through a cascade of intramolecular electrostatic interactions.

Acharya, P; Plashkevych, O; Morita, C; Yamada, S et al.

Ingår i J Org Chem, s. 1529-38, 2003

Tandem electrostatic effect from the first to the third aglycon in the trimeric RNA owing to the nearest-neighbor interaction.

Acharya, P; Acharya, S; Földesi, A; Chattopadhyaya, J

Ingår i J Am Chem Soc, s. 2094-100, 2003

The pK(a) of the internucleotidic 2'-hydroxyl group in diribonucleoside (3'-->5') monophosphates.

Acharya, S; Földesi, A; Chattopadhyaya, J

Ingår i J Org Chem, s. 1906-10, 2003

Antisense oligonuclotides with oxetane-constrained cytidine enhance heteroduplex stability, and elicit satisfactory RNase H response as well as showing improved resistance to both exo and endonucleases.

Pradeepkumar, Pushpangadan I; Amirkhanov, Nariman V; Chattopadhyaya, Jyoti

Ingår i Org Biomol Chem, s. 81-92, 2003

Studies towards the large scale chemical synthesis of the precursors of ribonucleosides-3',4',5',5''-2H4 and -2',3',4',5',5''-2H5.

Földesi, Andras; Chattopadhyaya, Jyoti

Ingår i Nucleosides Nucleotides Nucleic Acids, s. 2093-104, 2003

Kinetic Analysis of the RNA Cleavage of the oxetane modified Antisense-RNA Hybrid Duplex by RNase H.

Amirkhanov, N V; Pradeepkumar, P I; Chattopadhyaya, J

Ingår i J. Chem. Soc. Perkin 2, s. 976-984, 2002

The RNase H Affinity and Cleavage of the target RNA in the Antisense-RNA Hybrid Duplexes Containing various 3’-Tethered Substituents in the Antisense Strand.

Amirkhanov, N V; Chattopadhyaya, J

Ingår i J. Chem. Soc. Perkin 2, s. 271-281, 2002

The Hydrogen Bonding and Hydration of 2'-OH in Adenosine and Adenosine 3'-ethylphosphate.

Acharya, P; Chattopadhyaya, J

Ingår i J. Org. Chem., s. 1852-1865, 2002

An electrochemical probe of DNA stacking in an antisense oligonucleotide containing a C3'-endo-locked sugar.

Boon, Elizabeth M; Barton, Jacqueline K; Pradeepkumar, Pushpangadan I; Isaksson, Johan et al.

Ingår i Angew Chem Int Ed Engl, s. 3402-5, 2002

Synthesis of the DNA-[Ru(tpy)(dppz)(CH(3)CN)](2+) conjugates and their photo cross-linking studies with the complementary DNA strand.

Ossipov, Dimitri; Gohil, Suresh; Chattopadhyaya, Jyoti

Ingår i J Am Chem Soc, s. 13416-33, 2002

Cross-modulation of physicochemical character of aglycones in dinucleoside (3'-->5') monophosphates by the nearest neighbor interaction in the stacked state.

Acharya, S; Acharya, P; Földesi, A; Chattopadhyaya, J

Ingår i J Am Chem Soc, s. 13722-30, 2002

Experimental Evidences Unequivocally Prove the Role of Stereoelectronics as One of the Major Forces Responsible for the Self-assembly of DNA and RNA.

Acharya, P; Issakson, J; Pradeepkumar, P.I.; Chattopadhyaya, J

Ingår i Collect. Czech. Chem. Commun.: Collection Symposium Series (Chemistry of Nucleic Acid Components), s. 99-120, 2002

Synthesis of [Ru(phen)(2)dppz](2+)-tethered oligo-DNA and studies on the metallointercalation mode into the DNA duplex

Ossipov, D; Pradeepkumar, PI; Holmer, M; Chattopadhyaya, J

Ingår i JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, s. 3551-3562, 2001

Do we understand the molecular nature of antisense oligo/RNA hybrid duplex recognition by RNase H?

Chattopadhyaya, J

Ingår i Abstracts of papers of the American Chemical Society, 2001

The strength of the 3 '-gauche effect dictates the structure of 3 '-O-anthraniloyladenosine and its 5 '-phosphate, two analogues of the 3 '-end of aminoacyl-tRNA

Acharya, P; Nawrot, B; Sprinzl, M; Thibaudeau, C et al.

Ingår i JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, s. 1531-1536, 1999

MCR .3. Multicomponent reactions and their libraries, a new type of organic chemistry of the isocyanides and phosphorus derivatives.

Chattopadhyaya, J; Domling, A; Lorenz, K; Richter, W et al.

Ingår i NUCLEOSIDES & NUCLEOTIDES, s. 843-848, 1997

The use of 5'-phosphate derivatives of nucleoside analogs as inhibitors of HIV-1 replication

Nillroth, Ulrika; Vrang, Lotta; Ahlsén, Göran; Besidsky, Y et al.

Ingår i Antiviral Chemistry & Chemotherapy, s. 50-64, 1995

2',3'-DIDEOXY-3'-C,2'-N-[(3R,5R)-5-ETHOXYCARBONYL-2-METHYL-1,2-ISOXAZOLIDINE]-RIBOTHYMIDINE

BURKHART, BM; PAPCHIKHIN, A; CHATTOPADHYAYA, J; SUNDARALINGAM, M

Ingår i ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, s. 1462-1464, 1995

Synthetic siRNA targeting human papillomavirus 16 E6: a perspective on in vitro nanotherapeutic approaches

Togtema, Melissa; Jackson, Robert; Grochowski, Jessica; Villa, Peter L. et al.

Ingår i Nanomedicine, s. 455-474, 2018

• DOI för Synthetic siRNA targeting human papillomavirus 16 E6: a perspective on in vitro nanotherapeutic approaches

C2 '-F Stereoconfiguration As a Puckering Switch for Base Stacking at the Dinucleotide Level

Moriou, Céline; Da Silva, Adilson D.; Vianelli Prado, Marcos Joel; Denhez, Clément et al.

Ingår i Journal of Organic Chemistry, s. 2473-2478, 2018

• DOI för C2 '-F Stereoconfiguration As a Puckering Switch for Base Stacking at the Dinucleotide Level

How RNase HI (Escherichia coli) promoted site-selective hydrolysis works on RNA in duplex with carba-LNA and LNA substituted antisense strands in an antisense strategy context?

Plashkevych, Oleksandr; Li, Qing; Chattopadhyaya, Jyoti

Ingår i Molecular Biosystems, s. 921-938, 2017

• DOI för How RNase HI (Escherichia coli) promoted site-selective hydrolysis works on RNA in duplex with carba-LNA and LNA substituted antisense strands in an antisense strategy context?

A Minute Amount of S-Puckered Sugars Is Sufficient for (6-4) Photoproduct Formation at the Dinucleotide Level

Moriou, Celine; Denhez, Clement; Plashkeyych, Oleksandr; Coantic-Castex, Stephanie et al.

Ingår i Journal of Organic Chemistry, s. 615-619, 2015

• DOI för A Minute Amount of S-Puckered Sugars Is Sufficient for (6-4) Photoproduct Formation at the Dinucleotide Level

Distal Two-Bond versus Three-Bond Electronegative Oxo-Substituent Effect Controls the Kinetics and Thermodynamics of the Conversion of a C-Nitroso Function to the Corresponding Oxime in the Conformationally Locked Pentofuranose (Bicyclo[2.2.1]heptane) System

Karimiahmadabadi, Mansoureh; Erfan, Sayeh; Földesi, András; Chattopadhyaya, Jyoti

Ingår i Journal of Organic Chemistry, s. 7266-7276, 2014

• DOI för Distal Two-Bond versus Three-Bond Electronegative Oxo-Substituent Effect Controls the Kinetics and Thermodynamics of the Conversion of a C-Nitroso Function to the Corresponding Oxime in the Conformationally Locked Pentofuranose (Bicyclo[2.2.1]heptane) System

Synthetic siRNA targeting human papillomavirus 16 E6: a perspective on in vitro nanotherapeutic approaches

Togtema, Melissa; Jackson, Robert; Grochowski, Jessica; Villa, Peter L. et al.

Ingår i Nanomedicine, s. 455-474, 2018

• DOI för Synthetic siRNA targeting human papillomavirus 16 E6: a perspective on in vitro nanotherapeutic approaches

C2 '-F Stereoconfiguration As a Puckering Switch for Base Stacking at the Dinucleotide Level

Moriou, Céline; Da Silva, Adilson D.; Vianelli Prado, Marcos Joel; Denhez, Clément et al.

Ingår i Journal of Organic Chemistry, s. 2473-2478, 2018

• DOI för C2 '-F Stereoconfiguration As a Puckering Switch for Base Stacking at the Dinucleotide Level

How RNase HI (Escherichia coli) promoted site-selective hydrolysis works on RNA in duplex with carba-LNA and LNA substituted antisense strands in an antisense strategy context?

Plashkevych, Oleksandr; Li, Qing; Chattopadhyaya, Jyoti

Ingår i Molecular Biosystems, s. 921-938, 2017

• DOI för How RNase HI (Escherichia coli) promoted site-selective hydrolysis works on RNA in duplex with carba-LNA and LNA substituted antisense strands in an antisense strategy context?

A Minute Amount of S-Puckered Sugars Is Sufficient for (6-4) Photoproduct Formation at the Dinucleotide Level

Moriou, Celine; Denhez, Clement; Plashkeyych, Oleksandr; Coantic-Castex, Stephanie et al.

Ingår i Journal of Organic Chemistry, s. 615-619, 2015

• DOI för A Minute Amount of S-Puckered Sugars Is Sufficient for (6-4) Photoproduct Formation at the Dinucleotide Level

Distal Two-Bond versus Three-Bond Electronegative Oxo-Substituent Effect Controls the Kinetics and Thermodynamics of the Conversion of a C-Nitroso Function to the Corresponding Oxime in the Conformationally Locked Pentofuranose (Bicyclo[2.2.1]heptane) System

Karimiahmadabadi, Mansoureh; Erfan, Sayeh; Földesi, András; Chattopadhyaya, Jyoti

Ingår i Journal of Organic Chemistry, s. 7266-7276, 2014

• DOI för Distal Two-Bond versus Three-Bond Electronegative Oxo-Substituent Effect Controls the Kinetics and Thermodynamics of the Conversion of a C-Nitroso Function to the Corresponding Oxime in the Conformationally Locked Pentofuranose (Bicyclo[2.2.1]heptane) System

New antiprotozoal agents: Their synthesis and biological evaluations

Upadhayaya, Ram Shankar; Dixit, Shailesh S.; Földesi, András; Chattopadhyaya, Jyoti

Ingår i Bioorganic & Medicinal Chemistry Letters, s. 2750-2758, 2013

• DOI för New antiprotozoal agents: Their synthesis and biological evaluations

Steric Effects in the Tuning of the Diastereoselectivity of the Intramolecular Free-Radical Cyclization to an Olefin As Exemplified through the Synthesis of a Carba-Pentofuranose Scaffold

Karimi, Mansoureh; Erfan, Sayeh; Földesi, András; Chattopadhyaya, Jyoti

Ingår i Journal of Organic Chemistry, s. 6855-6872, 2012

• DOI för Steric Effects in the Tuning of the Diastereoselectivity of the Intramolecular Free-Radical Cyclization to an Olefin As Exemplified through the Synthesis of a Carba-Pentofuranose Scaffold

Unusual strain-releasing nucleophilic rearrangement of a bicyclo[2.2.1]heptane system to a cyclohexenyl derivative

Karimiahmadabadi, Mansoureh; Földesi, András; Chattopadhyaya, Jyoti

Ingår i Journal of Organic Chemistry, s. 9747-9755, 2012

• DOI för Unusual strain-releasing nucleophilic rearrangement of a bicyclo[2.2.1]heptane system to a cyclohexenyl derivative

Design and Divergent Synthesis of Aza Nucleosides from a Chiral Imino Sugar

Martinez-Montero, Saul; Fernandez, Susana; Sanghvi, Yogesh S.; Chattopadhyaya, Jyoti et al.

Ingår i Journal of Organic Chemistry, s. 4671-4678, 2012

• DOI för Design and Divergent Synthesis of Aza Nucleosides from a Chiral Imino Sugar

New parasite inhibitors encompassing novel conformationally-locked 5 '-acyl sulfamoyl adenosines

Dixit, Shailesh S.; Upadhayaya, Ram Shankar; Chattopadhyaya, Jyoti

Ingår i Organic and biomolecular chemistry, s. 6121-6129, 2012

• DOI för New parasite inhibitors encompassing novel conformationally-locked 5 '-acyl sulfamoyl adenosines

Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs

Hu, Jiaxin; Gagnon, Keith T.; Liu, Jing; Watts, Jonathan K. et al.

Ingår i Biological chemistry (Print), s. 315-325, 2011

• DOI för Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs

Synthesis and antimycobacterial activity of prodrugs of indeno[2,1-c]quinoline derivatives

Upadhayaya, Ram Shankar; Shinde, Popat D.; Kadam, Sandip A.; Bawane, Amit N. et al.

Ingår i European Journal of Medicinal Chemistry, s. 1306-1324, 2011

• DOI för Synthesis and antimycobacterial activity of prodrugs of indeno[2,1-c]quinoline derivatives

Carba-LNA-^5MeC/A/G/T Modified Oligos Show Nucleobase-Specific Modulation of 3′-Exonuclease Activity, Thermodynamic Stability, RNA Selectivity, and RNase H Elicitation: Synthesis and Biochemistry

Upadhayaya, RamShankar; Deshpande, Sachin Gangadhar; Li, Qing; Kardile, Ramakant Asaram et al.

Ingår i Journal of Organic Chemistry, s. 4408-4431, 2011

• DOI för Carba-LNA-^5MeC/A/G/T Modified Oligos Show Nucleobase-Specific Modulation of 3′-Exonuclease Activity, Thermodynamic Stability, RNA Selectivity, and RNase H Elicitation: Synthesis and Biochemistry

The R-diastereomer of 6 '-O-toluoyl-carba-LNA modification in the core region of siRNA leads to 24-times improved RNA silencing potency against the HIV-1 compared to its S-counterpart

Dutta, Suman; Bhaduri, Nipa; Upadhayaya, Ram Shankar; Rastogi, Neha et al.

Ingår i MedChemComm, s. 1110-1119, 2011

• DOI för The R-diastereomer of 6 '-O-toluoyl-carba-LNA modification in the core region of siRNA leads to 24-times improved RNA silencing potency against the HIV-1 compared to its S-counterpart

Molecular Structure of the Core-Modified siRNA Duplexes Containing Diastereomeric Pair of [C6′(R)-OH]- versus [C6′(S)-OH]-carba-LNAs Suggests a Model for RNAi Action

Plashkevych, Oleksandr; Chattopadhyaya, Jyoti

Ingår i Nucleosides, Nucleotides & Nucleic Acids, s. 815-825, 2011

• DOI för Molecular Structure of the Core-Modified siRNA Duplexes Containing Diastereomeric Pair of [C6′(R)-OH]- versus [C6′(S)-OH]-carba-LNAs Suggests a Model for RNAi Action

Carba-LNA modified siRNAs targeting HIV-1 TAR region downregulate HIV-1 replication successfully with enhanced potency

Dutta, Suman; Bhaduri, Nipa; Rastogi, Neha; Chandel, Sunita G. et al.

Ingår i MedChemComm, s. 206-216, 2011

• DOI för Carba-LNA modified siRNAs targeting HIV-1 TAR region downregulate HIV-1 replication successfully with enhanced potency

Why Carba-LNA-Modified Oligonucleotides Show Considerably Improved 3 '-Exonuclease Stability Compared to That of the LNA Modified or the Native Counterparts: A Michaelis-Menten Kinetic Analysis

Zhou, Chuanzheng; Chattopadhyaya, Jyoti

Ingår i Journal of Organic Chemistry, s. 2341-2349, 2010

• DOI för Why Carba-LNA-Modified Oligonucleotides Show Considerably Improved 3 '-Exonuclease Stability Compared to That of the LNA Modified or the Native Counterparts: A Michaelis-Menten Kinetic Analysis

Free-Radical Ring Closure to Conformationally Locked alpha-L-Carba-LNAs and Synthesis of Their Oligos: Nuclease Stability, Target RNA Specificity, and Elicitation of RNase H

Li, Qing; Yuan, Fengfeng; Zhou, Chuanzheng; Plashkevych, Oleksandr et al.

Ingår i Journal of Organic Chemistry, s. 6122-6140, 2010

• DOI för Free-Radical Ring Closure to Conformationally Locked alpha-L-Carba-LNAs and Synthesis of Their Oligos: Nuclease Stability, Target RNA Specificity, and Elicitation of RNase H

Synthesis and structure of azole-fused indeno[2,1-c]quinolines and their anti-mycobacterial properties

Upadhayaya, Ram Shankar; Shinde, Popat D.; Sayyed, Aftab Y.; Kadam, Sandip A. et al.

Ingår i Organic and biomolecular chemistry, s. 5661-5673, 2010

• DOI för Synthesis and structure of azole-fused indeno[2,1-c]quinolines and their anti-mycobacterial properties

Design, synthesis and biological evaluation of novel triazole, urea and thiourea derivatives of quinoline against Mycobacterium tuberculosis

Upadhayaya, Shankar; Kulkarni, Girish M.; Vasireddy, Rao; Vandavasi, Kishore et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 4681-4692, 2009

• DOI för Design, synthesis and biological evaluation of novel triazole, urea and thiourea derivatives of quinoline against Mycobacterium tuberculosis

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

Bramsen, Jesper B.; Laursen, Maria B; Nielsen, Anne F.; Hansen, Thomas B. et al.

Ingår i Nucleic Acids Research, s. 2867-2881, 2009

• DOI för A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

2-(4-Tolylsulfonyl)ethoxymethyl (TEM)-a new 2'-OH protecting group for solid-supported RNA synthesis

Zhou, Chuanzheng; Honcharenko, Dmytro; Chattopadhyaya, Jyoti

Ingår i Organic and biomolecular chemistry, s. 333-343, 2007

• DOI för 2-(4-Tolylsulfonyl)ethoxymethyl (TEM)-a new 2'-OH protecting group for solid-supported RNA synthesis

High-quality oligo-RNA synthesis using the new 2′-O-TEM protecting group by selectively quenching the addition of p-tolyl vinyl sulphone to exocyclic amino functions

Zhou, Chuanzheng; Pathmasiri, Wimal; Honcharenko, Dmytro; Chatterjee, Subhrangsu et al.

Ingår i Canadian journal of chemistry (Print), s. 293-301, 2007

• DOI för High-quality oligo-RNA synthesis using the new 2′-O-TEM protecting group by selectively quenching the addition of p-tolyl vinyl sulphone to exocyclic amino functions

Five- and Six-Membered Conformationally Locked 2‘,4‘-Carbocyclic ribo-Thymidines: Synthesis, Structure, and Biochemical Studies

Srivastava, Puneet; Barman, Jharna; Pathmasiri, Wimal; Plashkevych, Oleksandr et al.

Ingår i Journal of the American Chemical Society, s. 8362-8379, 2007

• DOI för Five- and Six-Membered Conformationally Locked 2‘,4‘-Carbocyclic ribo-Thymidines: Synthesis, Structure, and Biochemical Studies

Comparison of the RNase H Cleavage Kinetics and Blood Serum Stability of the North-Conformationally Constrained and 2‘-Alkoxy Modified Oligonucleotides

Honcharenko, Dmytro; Barman, Jharna; Varghese, Oommen P.; Chattopadhyaya, Jyoti

Ingår i Biochemistry, s. 5635-5646, 2007

• DOI för Comparison of the RNase H Cleavage Kinetics and Blood Serum Stability of the North-Conformationally Constrained and 2‘-Alkoxy Modified Oligonucleotides

Chemical and Structural Implications of 1‘,2‘- versus 2‘,4‘- Conformational Constraints in the Sugar Moiety of Modified Thymine Nucleosides

Plashkevych, Oleksandr; Chatterjee, Subhrangsu; Honcharenko, Dmytro; Pathmasiri, Wimal et al.

Ingår i Journal of Organic Chemistry, s. 4716-4726, 2007

• DOI för Chemical and Structural Implications of 1‘,2‘- versus 2‘,4‘- Conformational Constraints in the Sugar Moiety of Modified Thymine Nucleosides

Interactions of drugs and an oligonucleotide with charged membranes analyzed by immobilized liposome chromatography

Lundquist, Anna; Engvall, Caroline; Boija, Elisabet; Kurtovic, Sanela et al.

Ingår i Biomedical Chromatography, s. 83-87, 2006

• DOI för Interactions of drugs and an oligonucleotide with charged membranes analyzed by immobilized liposome chromatography

Non-identical electronic characters of the internucleotidic phosphates in RNA modulate the chemical reactivity of the phosphodiester bonds.

Barman, Jharna; Acharya, Sandipta; Zhou, Chuanzheng; Chatterjee, Subhrangsu et al.

Ingår i Org Biomol Chem, s. 928-41, 2006

Oxetane locked thymidine in the Dickerson-Drew dodecamer causes local base pairing distortions: an NMR structure and hydration study

Isaksson, Johan; Plashkevych, Oleksandr; Pradeepkumar, P. I.; Chatterjee, Subhrangsu et al.

Ingår i Journal of Biomolecular Structure and Dynamics, s. 299-330, 2005

• DOI för Oxetane locked thymidine in the Dickerson-Drew dodecamer causes local base pairing distortions: an NMR structure and hydration study

A uniform mechanism correlating dangling-end stabilization and stacking geometry.

Isaksson, J; Chattopadhyaya, J

Ingår i Biochemistry, s. 5390-401, 2005

Electrostatic Cross-modulation of the Pseudoaromatic Character in Single Stranded RNA by Nearest-neighbor interactions

Acharya, P; Chattopadhyaya, J

Ingår i Pure and Applied Chemistry, s. 291-311, 2005

2'/3'-O-peptidyl Adenosine as a General Base Catalyst of its Own External Peptidyl Transfer: Implications for the Ribosome Catalytic Mechanism.

Changalov, M M; Ivanova, G D; Rangelov, M A; Acharya, P et al.

Ingår i Chembiochem, s. 992-996, 2005

Significant pKa perturbation of nucleobases is an intrinsic property of the sequence context in DNA and RNA.

Acharya, Sandipta; Barman, Jharna; Cheruku, Pradeep; Chatterjee, Subhrangsu et al.

Ingår i J Am Chem Soc, s. 8674-81, 2004

Single-stranded adenine-rich DNA and RNA retain structural characteristics of their respective double-stranded conformations and show directional differences in stacking pattern.

Isaksson, J; Acharya, S; Barman, J; Cheruku, P et al.

Ingår i Biochemistry, s. 15996-6010, 2004

Oxetane modified, conformationally constrained, antisense oligodeoxyribonucleotides function efficiently as gene silencing molecules.

Opalinska, J B; Kalota, A; Gifford, Lida K; Lu, Ponzy et al.

Ingår i Nucleic Acids Res, s. 5791-9, 2004

Book Review on "Highlights in Bioorganic Chemistry"

Chattopadhyaya, J

Ingår i ChemBioChem, s. 1719, 2004

Measurement of nucleobase pKa values in model mononucleotides shows RNA-RNA duplexes to be more stable than DNA-DNA duplexes.

Acharya, P; Cheruku, P; Chatterjee, S; Acharya, S et al.

Ingår i J Am Chem Soc, s. 2862-9, 2004

Synthesis of 2'-2H1-Ribonucleosides

Földesi, A; Kundu, M K; Dinya, Z; Chattopadhyaya, J

Ingår i Helvetica Chemica Acta, s. 742-757, 2004

Synthesis, physicochemical and biochemical studies of 1',2'-oxetane constrained adenosine and guanosine modified oligonucleotides, and their comparison with those of the corresponding cytidine and thymidine analogues.

Pradeepkumar, Pushpangadan I; Cheruku, Pradeep; Plashkevych, Oleksandr; Acharya, Parag et al.

Ingår i J Am Chem Soc, s. 11484-99, 2004

Human deoxycytidine kinase as a deoxyribonucleoside phosphorylase.

Usova, Elena; Maltseva, Tatiana; Földesi, Andras; Chattopadhyaya, Jyoti et al.

Ingår i J Mol Biol, s. 1347-58, 2004

Studies on the Stereoselective Synthesis of Deuterated- Ribose Derivatives

Kundu, M K; Földesi, A; Chattopadhyaya, J

Ingår i Helvetica Chemica Acta, s. 633-643, 2003

A repertoire of pyridinium-phenyl-methyl cross-talk through a cascade of intramolecular electrostatic interactions.

Acharya, P; Plashkevych, O; Morita, C; Yamada, S et al.

Ingår i J Org Chem, s. 1529-38, 2003

Tandem electrostatic effect from the first to the third aglycon in the trimeric RNA owing to the nearest-neighbor interaction.

Acharya, P; Acharya, S; Földesi, A; Chattopadhyaya, J

Ingår i J Am Chem Soc, s. 2094-100, 2003

The pK(a) of the internucleotidic 2'-hydroxyl group in diribonucleoside (3'-->5') monophosphates.

Acharya, S; Földesi, A; Chattopadhyaya, J

Ingår i J Org Chem, s. 1906-10, 2003

Antisense oligonuclotides with oxetane-constrained cytidine enhance heteroduplex stability, and elicit satisfactory RNase H response as well as showing improved resistance to both exo and endonucleases.

Pradeepkumar, Pushpangadan I; Amirkhanov, Nariman V; Chattopadhyaya, Jyoti

Ingår i Org Biomol Chem, s. 81-92, 2003

Studies towards the large scale chemical synthesis of the precursors of ribonucleosides-3',4',5',5''-2H4 and -2',3',4',5',5''-2H5.

Földesi, Andras; Chattopadhyaya, Jyoti

Ingår i Nucleosides Nucleotides Nucleic Acids, s. 2093-104, 2003

Kinetic Analysis of the RNA Cleavage of the oxetane modified Antisense-RNA Hybrid Duplex by RNase H.

Amirkhanov, N V; Pradeepkumar, P I; Chattopadhyaya, J

Ingår i J. Chem. Soc. Perkin 2, s. 976-984, 2002

The RNase H Affinity and Cleavage of the target RNA in the Antisense-RNA Hybrid Duplexes Containing various 3’-Tethered Substituents in the Antisense Strand.

Amirkhanov, N V; Chattopadhyaya, J

Ingår i J. Chem. Soc. Perkin 2, s. 271-281, 2002

The Hydrogen Bonding and Hydration of 2'-OH in Adenosine and Adenosine 3'-ethylphosphate.

Acharya, P; Chattopadhyaya, J

Ingår i J. Org. Chem., s. 1852-1865, 2002

An electrochemical probe of DNA stacking in an antisense oligonucleotide containing a C3'-endo-locked sugar.

Boon, Elizabeth M; Barton, Jacqueline K; Pradeepkumar, Pushpangadan I; Isaksson, Johan et al.

Ingår i Angew Chem Int Ed Engl, s. 3402-5, 2002

Synthesis of the DNA-[Ru(tpy)(dppz)(CH(3)CN)](2+) conjugates and their photo cross-linking studies with the complementary DNA strand.

Ossipov, Dimitri; Gohil, Suresh; Chattopadhyaya, Jyoti

Ingår i J Am Chem Soc, s. 13416-33, 2002

Cross-modulation of physicochemical character of aglycones in dinucleoside (3'-->5') monophosphates by the nearest neighbor interaction in the stacked state.

Acharya, S; Acharya, P; Földesi, A; Chattopadhyaya, J

Ingår i J Am Chem Soc, s. 13722-30, 2002

Experimental Evidences Unequivocally Prove the Role of Stereoelectronics as One of the Major Forces Responsible for the Self-assembly of DNA and RNA.

Acharya, P; Issakson, J; Pradeepkumar, P.I.; Chattopadhyaya, J

Ingår i Collect. Czech. Chem. Commun.: Collection Symposium Series (Chemistry of Nucleic Acid Components), s. 99-120, 2002

Synthesis of [Ru(phen)(2)dppz](2+)-tethered oligo-DNA and studies on the metallointercalation mode into the DNA duplex

Ossipov, D; Pradeepkumar, PI; Holmer, M; Chattopadhyaya, J

Ingår i JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, s. 3551-3562, 2001

Do we understand the molecular nature of antisense oligo/RNA hybrid duplex recognition by RNase H?

Chattopadhyaya, J

Ingår i Abstracts of papers of the American Chemical Society, 2001

The strength of the 3 '-gauche effect dictates the structure of 3 '-O-anthraniloyladenosine and its 5 '-phosphate, two analogues of the 3 '-end of aminoacyl-tRNA

Acharya, P; Nawrot, B; Sprinzl, M; Thibaudeau, C et al.

Ingår i JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, s. 1531-1536, 1999

MCR .3. Multicomponent reactions and their libraries, a new type of organic chemistry of the isocyanides and phosphorus derivatives.

Chattopadhyaya, J; Domling, A; Lorenz, K; Richter, W et al.

Ingår i NUCLEOSIDES & NUCLEOTIDES, s. 843-848, 1997

The use of 5'-phosphate derivatives of nucleoside analogs as inhibitors of HIV-1 replication

Nillroth, Ulrika; Vrang, Lotta; Ahlsén, Göran; Besidsky, Y et al.

Ingår i Antiviral Chemistry & Chemotherapy, s. 50-64, 1995

2',3'-DIDEOXY-3'-C,2'-N-[(3R,5R)-5-ETHOXYCARBONYL-2-METHYL-1,2-ISOXAZOLIDINE]-RIBOTHYMIDINE

BURKHART, BM; PAPCHIKHIN, A; CHATTOPADHYAYA, J; SUNDARALINGAM, M

Ingår i ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, s. 1462-1464, 1995

Intramolecular Free-Radical Cyclization Reactions on Pentose Sugars for the Synthesis of Carba-LNA and Carba-ENA and the Application of Their Modified Oligonucleotides as Potential RNA Targeted Therapeutics

Zhou, Chuanzheng; Chattopadhyaya, Jyoti

Ingår i Chemical Reviews, s. 3808-3832, 2012

• DOI för Intramolecular Free-Radical Cyclization Reactions on Pentose Sugars for the Synthesis of Carba-LNA and Carba-ENA and the Application of Their Modified Oligonucleotides as Potential RNA Targeted Therapeutics

Modified Nucleosides and Nucleotides and Their Use Thereof.

Chattopadhyaya, J

2004