Customized Microfluidics
Customized Microfluidics exists to advance Swedish life science research by providing support in the design and fabrication of microfluidic systems customized for your specific research needs. Our range of services are available to research groups at all Swedish universities as well as national SMEs that will benefit from introducing microfluidic solutions to their research and R&D.
We offer:
- Research support, including:
- Design input for the microfluidic platform
- Fabrication of microfluidic components
- Functionality testing before delivery
- Advice on peripheral equipment needed for device operation
- Test bed for users to assess their microfluidic devices with high-end pumps and microscope
- One free consultation meeting with an expert to discuss your project needs, including suggestions on commercially available solutions and cost estimation
- Scientific and budgetary advice for grant applications
Research Support
Should you wish to initiate a project with Customized Microfluidics, you will work through a series of phases and decision gates which assist in project tracking and ensuring your goals and expectations are in line with our processes.
Test Bed - NEW -
Customized Microfluidics is pleased to announce an exciting new opportunity for users to test their microfluidic devices with high-end pumps and microscope available at Uppsala University. Users can book the equipment for up to 80 (non-consecutive) hours at a rate of 150 SEK per hour. Contact laurent.barbe@angstrom.uu.se for more details.
Concept
When you first approach Customized Microfluidics, you will be offered a free 1-hour consultation to discuss your project needs and whether this service is the right one for you. This meeting will be held with one of our experts either in person, by phone or by Zoom, who will listen to your ideas and gather information regarding your requirements. As well as discussing a potential project, we can provide budgetary and scientific input for funding applications, and even recommend other commercial suppliers or foundries that are best suited to your needs. Customized Microfluidics reserves the right to decline requests due to limited resources, technically unfeasible requests or where more suitable commercially available options are available. If there are IPR issues within the project, we are able to provide a non-disclosure agreement.
Our expert will investigate the required fabrication processes of the envisioned device and in this way assess the feasibility of the requested design. If necessary, we provide feedback and/or propose iterations to create a feasible prototype. If both sides agree that the project is feasible and wish to proceed, you will move onto the next phase. You will be asked to sign a Project Cooperation Agreement before further development and production, which lays out the terms of the service provision and includes important information such as the project plan, expected budget and delivery date.
Development, Production & Validation
One of our experts will be responsible for the design and development process. Based on all existing information, a design is made that will be presented to you. The time frame of a prototype run depends on the complexity of the microsystem and fabrication design, and the subsequent number of adjustments that have to be made. Every request is unique, and as such, the development-production-validation stages may be iterative. Finally, you can expect to receive a device according to the approved design.
Equipment
Here you can find a list of equipment used by Customized Microfluidics:
- UV lithography (including SU-8)
- Nanoimprinting (COC, kapton, etc)
- Electron beam lithogra
- phy (EBL)
- Two-photon polymerization printer (2PP)
- Sputtering
- Evaporators
- Oxidation furnaces
- Reactive ion etcher (RIE)
- Anodic bonder (Si/glass)
- Fusion bonder furnace (glass/glass)
- Vinyl plotter
- Dry films laminator
- Micromilling
- Laser cutter (nanoseconds laser)
- Dicing saw
- Scanning electron microscope (SEM)
- Optical profilometer
- Atomic force microscope (AFM)
A more complete list of available equipment can be found at http://lims.msl.angstrom.uu.se/
Case Studies
To date, Customized Microfluidics has worked with academic researchers from across 10 different Swedish universities. Scroll down to explore a number of case studies to show the range of capabilities available through our service.
Publications
Where have we been acknowledged?
2022
International Journal of Pharmaceutics
"Microfluidics platform for studies of peptide – polyelectrolyte interaction"
M. Wanselius, S. Searle, A. Rodler, M. Tenje, S. Abrahms´en-Alami,
P. Hansson
2021
RSC Advances
"Fabrication and characterisation of a silicon-borosilicate glass microfluidic device for synchrotron-based hard X-ray spectroscopy studies"
P. M. Raj, L. Barbe, M. Andersson, M. De Albuquerque Moreira, D. Haase, J. Wootton, S. Nehzati, A. E. Terry, R. J. Friel, M. Tenje and K. G. V. Sigfridsson Clauss
https://doi.org/10.1039/D1RA05270E
Lab on a chip
"A microscopy-compatible temperature regulation system for single-cell phenotype analysis – demonstrated by thermoresponse mapping of microalgae"
M. Andersson, S. Johansson, H. Bergman, L. Xiao, L. Behrendt and M.Tenje
https://doi.org/10.1039/D0LC01288B
ACS Applied Materials & Interfaces
"Sorption of Neuropsychopharmaca in Microfluidic Materials for In Vitro Studies"
T. E. Winkler and A. Herland
2020
Micromachines
"Fabrication of Silicon Microfluidic Chips for Acoustic
Particle Focusing Using Direct Laser Writing"
A. Fornell, P. Söderbäck, Z. Liu, M. De Albuquerque Moreira and M. Tenje
FAQs
Who is welcome?
Our mission is to support researcher groups at all Swedish universities and national SMEs that will benefit from introducing microfluidic solutions to their research and R&D.
What costs are involved?
Our initial support and advice is free of charge for Swedish researchers. After discussion between you and the facility, and should you wish to pursue a project with us, we will be able to provide a time and cost estimate based on your needs.
How does the facility prioritize projects?
Scientific quality is always our main priority in choosing among the projects.
How long does it take until my chip is ready?
This depends on the complexity of the microsystem design and fabrication. It is our ambition that first prototype should be delivered within 1-2 months but in some cases it may take longer.
How does the facility handle IPRs?
Already at the first meeting we will discuss any IPR issues involved in the project and if you prefer, we provide a NDA.
Want to get in touch? We'd love to hear from you
By email: laurent.barbe@angstrom.uu.se
By phone: +46 (0) 18 471 72 35
By post: Box 35, 751 03 UPPSALA, SWEDEN
In person: Ångströmlaboratoriet, House 2, 2nd floor, Lägerhyddsvägen 1, 751 20 UPPSALA, SWEDEN