Clinical Neurophysiology
The research in the clinical neurophysiology unit is translational and focuses on optimizing neurophysiological parameters for diagnosis and follow-up of diseases of the peripheral and central nervous system. We have a preclinical lab with a method for measuring detailed extracellular signals from muscle and nerve cells to better map disease mechanisms.
Description of our research
Some examples of ongoing projects are biomarker development in myasthenia gravis (MG), muscle ultrasound in myopathies and analysis of the mechanisms that result in disturbed neuromuscular and neuronal signaling in autoimmune diseases such as MG. The research group also includes a number of clinical doctors and researchers who work with various projects in method development for diagnostics and follow-up. These projects aim, among other things, to improve the location of epileptic foci and to develop new methods in intraoperative monitoring and during intensive care.
Group members
Publications
Part of Brain and Behavior, 2024
Generalized myasthenia gravis with acetylcholine receptor antibodies: A guidance for treatment
Part of European Journal of Neurology, 2024
Elevated C1s/C1-INH in serum and plasma of myasthenia gravis patients
Part of Journal of Neuroimmunology, 2024
Part of iScience, p. 110564, 2024
- DOI for Serum protein biomarker profile distinguishes acetylcholine receptor antibody seropositive myasthenia gravis patients from healthy controls.
- Download full text (pdf) of Serum protein biomarker profile distinguishes acetylcholine receptor antibody seropositive myasthenia gravis patients from healthy controls.
Part of Muscle and Nerve, 2024
Part of European Journal of Neurology, 2024
Keeping up appearances: Don't frown upon the effects of botulinum toxin injections in facial muscles
Part of Clinical Neurophysiology Practice, p. 169-173, 2023
Part of Acta Neurologica Scandinavica, 2023
- DOI for Antibody-Positive Autoimmune Encephalitis and Paraneoplastic Neurological Syndrome: Epidemiology and Outcome of Neuronal Antibody Testing in Sweden
- Download full text (pdf) of Antibody-Positive Autoimmune Encephalitis and Paraneoplastic Neurological Syndrome: Epidemiology and Outcome of Neuronal Antibody Testing in Sweden
Part of European Journal of Neurology, p. 266-282, 2023
- DOI for Role of autoantibody levels as biomarkers in the management of patients with myasthenia gravis: A systematic review and expert appraisal
- Download full text (pdf) of Role of autoantibody levels as biomarkers in the management of patients with myasthenia gravis: A systematic review and expert appraisal
Part of Neuromuscular Disorders, p. 334-338, 2023
Part of JAMA Neurology, p. 1105-1112, 2022
Enrichment of serum IgG4 in MuSK myasthenia gravis patients
Part of Journal of Neuroimmunology, 2022
Part of Advanced Functional Materials, 2022
Epidemiology, diagnostics, and biomarkers of autoimmune neuromuscular junction disorders
Part of Lancet Neurology, p. 176-188, 2022
Part of Cells, 2022
Novel pathogenic ALG2 mutation causing congenital myasthenic syndrome: A case report
Part of Neuromuscular Disorders, p. 80-83, 2022
Part of European Journal of Neurology, p. 1706-1715, 2021
- DOI for Cancer in myasthenia gravis subtypes in relation to immunosuppressive treatment and acetylcholine receptor antibodies: A Swedish nationwide register study
- Download full text (pdf) of Cancer in myasthenia gravis subtypes in relation to immunosuppressive treatment and acetylcholine receptor antibodies: A Swedish nationwide register study
Part of Clinical Neurophysiology, p. 1733-1740, 2021
Epidemiology of Myasthenia Gravis in Sweden 2006-2016
Part of Brain and Behavior, 2020
Part of Clinical Neurophysiology Practice, p. 46-49, 2020
Mortality rates and causes of death in Swedish Myasthenia Gravis patients
Part of Neuromuscular Disorders, p. 815-824, 2020
Myasthenia gravis patient and physician opinions about immunosuppressant reduction
Part of Muscle and Nerve, p. 767-772, 2020
Myasthenia Gravis and Physical Exercise: A Novel Paradigm
Part of Frontiers in Neurology, 2020
Part of Frontiers in Immunology, 2020
- DOI for Estrogen Receptor, Inflammatory, and FOXO Transcription Factors Regulate Expression of Myasthenia Gravis-Associated Circulating microRNAs
- Download full text (pdf) of Estrogen Receptor, Inflammatory, and FOXO Transcription Factors Regulate Expression of Myasthenia Gravis-Associated Circulating microRNAs
Circulating miRNAs as Potential Biomarkers in Myasthenia Gravis: Tools for Personalized Medicine
Part of Frontiers in Immunology, 2020
miR-1933-3p is upregulated in skeletal muscles of MuSK+ EAMG mice and affects Impa1 and Mrpl27
Part of Neuroscience research, p. 46-52, 2020
Pattern of Habitual Physical Exercise in Myasthenia Gravis Patients
Part of JOURNAL OF NEUROMUSCULAR DISEASES, p. 85-91, 2019
Part of BMJ Open, 2019
- DOI for Study protocol for a randomised controlled trial with clinical, neurophysiological, laboratory and radiological outcome for surgical versus non-surgical treatment for lumbar spinal stenosis: the Uppsala Spinal Stenosis Trial (UppSten)
- Download full text (pdf) of Study protocol for a randomised controlled trial with clinical, neurophysiological, laboratory and radiological outcome for surgical versus non-surgical treatment for lumbar spinal stenosis: the Uppsala Spinal Stenosis Trial (UppSten)
Cognitive dysfunction in mice with passively induced MuSK antibody seropositive myasthenia gravis
Part of Journal of the Neurological Sciences, p. 15-21, 2019
Facing the challenges of electrodiagnostic studies in the very elderly (>80 years) population
Part of Clinical Neurophysiology, p. 1091-1097, 2019
miR-30e-5p as predictor of generalization in ocular myasthenia gravis
Part of Annals of clinical and translational neurology, p. 243-251, 2019
Inflammatory and anti-inflammatory markers in plasma: from late pregnancy to early postpartum
Part of Scientific Reports, 2019
Circulating microRNA plasma profile in MuSK plus myasthenia gravis
Part of Journal of Neuroimmunology, p. 87-91, 2018
Advances in autoimmune myasthenia gravis management
Part of Expert Review of Neurotherapeutics, p. 573-588, 2018
Long-Term High-Density Extracellular Recordings Enable Studies of Muscle Cell Physiology
Part of Frontiers in Physiology, 2018
Part of Journal of Neuroimmunology, p. 164-170, 2018
Lifestyle factors and disease-specific differences in subgroups of Swedish Myasthenia Gravis
Part of Acta Neurologica Scandinavica, p. 557-565, 2018
Thymectomy lowers the myasthenia gravis biomarker miR-150-5p
Part of Neurology, 2018
Part of Medicine, 2018
Circulating microRNAs as potential biomarkers in myasthenia gravis patients.
Part of Annals of the New York Academy of Sciences, p. 33-40, 2018
High-resistance strength training does not affect nerve cross sectional area – An ultrasound study
Part of Clinical Neurophysiology Practice, p. 163-169, 2017
Part of Journal of clinical neurophysiology, p. 400-407, 2017
Part of Toxins, 2017
- DOI for Neurophysiological Measures of Efficacy and Safety for Botulinum Toxin Injection in Facial and Bulbar Muscles: Special Considerations
- Download full text (pdf) of Neurophysiological Measures of Efficacy and Safety for Botulinum Toxin Injection in Facial and Bulbar Muscles: Special Considerations
Part of Brain and Behavior, 2017
Part of Muscle and Nerve, p. 207-214, 2017
Profile of upregulated inflammatory proteins in sera of Myasthenia Gravis patients.
Part of Scientific Reports, 2017
Part of Clinical Neurophysiology, p. 3480-3484, 2016
Part of Dermatologic Surgery, p. 967-976, 2016
Compound Motor Action Potential: Electrophysiological Marker for Muscle Training
Part of Journal of clinical neurophysiology, p. 340-345, 2016
Part of Acta Neurologica Belgica, p. 57-63, 2016