Clinical Neurophysiology

Six test tubes with different coloured corks in a test tube rack.

The research in the clinical neurophysiology unit is translational and focuses on optimizing neurophysiological parameters for diagnosis and follow-up of diseases of the peripheral and central nervous system. We have a preclinical lab with a method for measuring detailed extracellular signals from muscle and nerve cells to better map disease mechanisms.

Our research

Our research focuses on understanding the mechanisms underlying disturbed neuronal and neuromuscular signaling and on developing novel diagnostic tools, biomarkers, and personalized treatment strategies for patients with neurological disorders.

We conduct translational research spanning advanced cellular models, molecular analyses, clinical studies, and population-based registry research. Our overarching goal is to bridge the gap between laboratory discoveries and patient care, enabling precision medicine approaches in neurology.

A major research focus is myasthenia gravis (MG), where we investigate both disease mechanisms and novel circulating biomarkers, including microRNAs, inflammatory proteins, and complement-related factors. Using human cell-based models of the neuromuscular junction, we study how pathogenic autoantibodies disrupt communication between nerves and muscles and evaluate new therapeutic strategies.

Our group also conducts research on facial nerve palsy, the neuromuscular effects of botulinum toxin, and immune-mediated mechanisms in neurological diseases. Through the FACE (Facial nerve palsy: A Comprehensive Exploration for Precision Medicine) initiative, we develop novel biomarkers and prognostic tools to improve individualized patient care.

The research group includes several clinician-scientists working on methodological development within clinical neurophysiology. These projects aim to improve the diagnosis, prognosis, and monitoring of neuromuscular disorders, including amyotrophic lateral sclerosis (ALS), myasthenia gravis, and other diseases affecting nerve and muscle function.

By integrating clinical neurophysiology, immunology, molecular biology, advanced imaging, and artificial intelligence, we strive to develop the next generation of diagnostic and therapeutic tools for neurological diseases.

Student Projects

We welcome highly motivated BSc, MSc, and medical students interested in:

  • Biomarker discovery in autoimmune neurological disorders
  • Functional immune profiling
  • Human neuromuscular junction models
  • Stem cell-derived neuronal systems
  • Machine learning and biomarker prediction
  • Clinical neurophysiology and precision medicine

Interested students are encouraged to contact the research group for available projects.

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