Klinisk neurofysiologi
Forskningen vid klinisk neurofysiologi är translationell och fokuserar på att optimera neurofysiologiska parametrar för diagnostik och uppföljning av sjukdomar i perifera och centrala nervsystemet. Vi har ett prekliniskt lab med en metod för att detaljerat mäta extracellulära signaler från muskel- och nervceller för att bättre kartlägga sjukdomsmekanismer.
Beskrivning av vår forskning
Några exempel på pågående projekt är biomarkörutveckling vid myasthenia gravis (MG), muskelultraljud vid myopatier och analys av mekanismerna som resulterar i störd neuromuskulär samt neuronal signalering vid autoimmuna sjukdomar såsom MG. Till forskargruppen hör även ett flertal kliniska läkare och forskare som arbetar med olika projekt inom metodutveckling för diagnostik och uppföljning. Dessa projekt syftar bland annat till att förbättra lokaliseringen av epileptiska foci samt utveckla nya metoder inom intraoperativ övervakning och under intensivvård.
Gruppmedlemmar
Publikationer
Ingår i Clinical Nuclear Medicine, s. 208-213, 2025
Ingår i Muscle and Nerve, s. 851-861, 2024
- DOI för Visualization and characterization of complement activation in acetylcholine receptor antibody seropositive myasthenia gravis
- Ladda ner fulltext (pdf) av Visualization and characterization of complement activation in acetylcholine receptor antibody seropositive myasthenia gravis
Ingår i Brain and Behavior, 2024
- DOI för Antibody-positive autoimmune encephalitis and paraneoplastic neurological syndrome: A Swedish case series
- Ladda ner fulltext (pdf) av Antibody-positive autoimmune encephalitis and paraneoplastic neurological syndrome: A Swedish case series
Generalized myasthenia gravis with acetylcholine receptor antibodies: A guidance for treatment
Ingår i European Journal of Neurology, 2024
- DOI för Generalized myasthenia gravis with acetylcholine receptor antibodies: A guidance for treatment
- Ladda ner fulltext (pdf) av Generalized myasthenia gravis with acetylcholine receptor antibodies: A guidance for treatment
Elevated C1s/C1-INH in serum and plasma of myasthenia gravis patients
Ingår i Journal of Neuroimmunology, 2024
- DOI för Elevated C1s/C1-INH in serum and plasma of myasthenia gravis patients
- Ladda ner fulltext (pdf) av Elevated C1s/C1-INH in serum and plasma of myasthenia gravis patients
Ingår i iScience, s. 110564, 2024
- DOI för Serum protein biomarker profile distinguishes acetylcholine receptor antibody seropositive myasthenia gravis patients from healthy controls.
- Ladda ner fulltext (pdf) av Serum protein biomarker profile distinguishes acetylcholine receptor antibody seropositive myasthenia gravis patients from healthy controls.
Ingår i Muscle and Nerve, s. 284-289, 2024
- DOI för Short-term changes in serum miRNA levels and patient-reported clinical outcomes in myasthenia gravis.
- Ladda ner fulltext (pdf) av Short-term changes in serum miRNA levels and patient-reported clinical outcomes in myasthenia gravis.
Ingår i European Journal of Neurology, 2024
- DOI för Pregnancy outcomes for women with myasthenia gravis and their newborns: A nationwide register-based cohort study
- Ladda ner fulltext (pdf) av Pregnancy outcomes for women with myasthenia gravis and their newborns: A nationwide register-based cohort study
Keeping up appearances: Don't frown upon the effects of botulinum toxin injections in facial muscles
Ingår i Clinical Neurophysiology Practice, s. 169-173, 2023
- DOI för Keeping up appearances: Don't frown upon the effects of botulinum toxin injections in facial muscles
- Ladda ner fulltext (pdf) av Keeping up appearances: Don't frown upon the effects of botulinum toxin injections in facial muscles
Ingår i Acta Neurologica Scandinavica, 2023
- DOI för Antibody-Positive Autoimmune Encephalitis and Paraneoplastic Neurological Syndrome: Epidemiology and Outcome of Neuronal Antibody Testing in Sweden
- Ladda ner fulltext (pdf) av Antibody-Positive Autoimmune Encephalitis and Paraneoplastic Neurological Syndrome: Epidemiology and Outcome of Neuronal Antibody Testing in Sweden
Ingår i European Journal of Neurology, s. 266-282, 2023
- DOI för Role of autoantibody levels as biomarkers in the management of patients with myasthenia gravis: A systematic review and expert appraisal
- Ladda ner fulltext (pdf) av Role of autoantibody levels as biomarkers in the management of patients with myasthenia gravis: A systematic review and expert appraisal
Ingår i Neuromuscular Disorders, s. 334-338, 2023
- DOI för Implementation of tailored exercise programs for MG patients in a gym setting: a pragmatic feasibility case study
- Ladda ner fulltext (pdf) av Implementation of tailored exercise programs for MG patients in a gym setting: a pragmatic feasibility case study
Ingår i JAMA Neurology, s. 1105-1112, 2022
Enrichment of serum IgG4 in MuSK myasthenia gravis patients
Ingår i Journal of Neuroimmunology, 2022
- DOI för Enrichment of serum IgG4 in MuSK myasthenia gravis patients
- Ladda ner fulltext (pdf) av Enrichment of serum IgG4 in MuSK myasthenia gravis patients
Ingår i Advanced Functional Materials, 2022
Epidemiology, diagnostics, and biomarkers of autoimmune neuromuscular junction disorders
Ingår i Lancet Neurology, s. 176-188, 2022
Ingår i Cells, 2022
- DOI för Towards Personalized Medicine in Myasthenia Gravis: Role of Circulating microRNAs miR-30e-5p, miR-150-5p and miR-21-5p
- Ladda ner fulltext (pdf) av Towards Personalized Medicine in Myasthenia Gravis: Role of Circulating microRNAs miR-30e-5p, miR-150-5p and miR-21-5p
Novel pathogenic ALG2 mutation causing congenital myasthenic syndrome: A case report
Ingår i Neuromuscular Disorders, s. 80-83, 2022
- DOI för Novel pathogenic ALG2 mutation causing congenital myasthenic syndrome: A case report
- Ladda ner fulltext (pdf) av Novel pathogenic ALG2 mutation causing congenital myasthenic syndrome: A case report
Ingår i European Journal of Neurology, s. 1706-1715, 2021
- DOI för Cancer in myasthenia gravis subtypes in relation to immunosuppressive treatment and acetylcholine receptor antibodies: A Swedish nationwide register study
- Ladda ner fulltext (pdf) av Cancer in myasthenia gravis subtypes in relation to immunosuppressive treatment and acetylcholine receptor antibodies: A Swedish nationwide register study
Ingår i Clinical Neurophysiology, s. 1733-1740, 2021
- DOI för Critical illness polyneuropathy, myopathy and neuronal biomarkers in COVID-19 patients: A prospective study
- Ladda ner fulltext (pdf) av Critical illness polyneuropathy, myopathy and neuronal biomarkers in COVID-19 patients: A prospective study
Epidemiology of Myasthenia Gravis in Sweden 2006-2016
Ingår i Brain and Behavior, 2020
- DOI för Epidemiology of Myasthenia Gravis in Sweden 2006-2016
- Ladda ner fulltext (pdf) av Epidemiology of Myasthenia Gravis in Sweden 2006-2016
Ingår i Clinical Neurophysiology Practice, s. 46-49, 2020
- DOI för Botulinum toxin injections associated with suspected myasthenia gravis: An underappreciated cause of MG-like clinical presentation
- Ladda ner fulltext (pdf) av Botulinum toxin injections associated with suspected myasthenia gravis: An underappreciated cause of MG-like clinical presentation
Mortality rates and causes of death in Swedish Myasthenia Gravis patients
Ingår i Neuromuscular Disorders, s. 815-824, 2020
- DOI för Mortality rates and causes of death in Swedish Myasthenia Gravis patients
- Ladda ner fulltext (pdf) av Mortality rates and causes of death in Swedish Myasthenia Gravis patients
Myasthenia gravis patient and physician opinions about immunosuppressant reduction
Ingår i Muscle and Nerve, s. 767-772, 2020
Myasthenia Gravis and Physical Exercise: A Novel Paradigm
Ingår i Frontiers in Neurology, 2020
- DOI för Myasthenia Gravis and Physical Exercise: A Novel Paradigm
- Ladda ner fulltext (pdf) av Myasthenia Gravis and Physical Exercise: A Novel Paradigm
Ingår i Frontiers in Immunology, 2020
- DOI för Estrogen Receptor, Inflammatory, and FOXO Transcription Factors Regulate Expression of Myasthenia Gravis-Associated Circulating microRNAs
- Ladda ner fulltext (pdf) av Estrogen Receptor, Inflammatory, and FOXO Transcription Factors Regulate Expression of Myasthenia Gravis-Associated Circulating microRNAs
Circulating miRNAs as Potential Biomarkers in Myasthenia Gravis: Tools for Personalized Medicine
Ingår i Frontiers in Immunology, 2020
- DOI för Circulating miRNAs as Potential Biomarkers in Myasthenia Gravis: Tools for Personalized Medicine
- Ladda ner fulltext (pdf) av Circulating miRNAs as Potential Biomarkers in Myasthenia Gravis: Tools for Personalized Medicine
miR-1933-3p is upregulated in skeletal muscles of MuSK+ EAMG mice and affects Impa1 and Mrpl27
Ingår i Neuroscience research, s. 46-52, 2020
Pattern of Habitual Physical Exercise in Myasthenia Gravis Patients
Ingår i JOURNAL OF NEUROMUSCULAR DISEASES, s. 85-91, 2019
Ingår i BMJ Open, 2019
- DOI för Study protocol for a randomised controlled trial with clinical, neurophysiological, laboratory and radiological outcome for surgical versus non-surgical treatment for lumbar spinal stenosis: the Uppsala Spinal Stenosis Trial (UppSten)
- Ladda ner fulltext (pdf) av Study protocol for a randomised controlled trial with clinical, neurophysiological, laboratory and radiological outcome for surgical versus non-surgical treatment for lumbar spinal stenosis: the Uppsala Spinal Stenosis Trial (UppSten)
Cognitive dysfunction in mice with passively induced MuSK antibody seropositive myasthenia gravis
Ingår i Journal of the Neurological Sciences, s. 15-21, 2019
Facing the challenges of electrodiagnostic studies in the very elderly (>80 years) population
Ingår i Clinical Neurophysiology, s. 1091-1097, 2019
miR-30e-5p as predictor of generalization in ocular myasthenia gravis
Ingår i Annals of clinical and translational neurology, s. 243-251, 2019
- DOI för miR-30e-5p as predictor of generalization in ocular myasthenia gravis
- Ladda ner fulltext (pdf) av miR-30e-5p as predictor of generalization in ocular myasthenia gravis
Inflammatory and anti-inflammatory markers in plasma: from late pregnancy to early postpartum
Ingår i Scientific Reports, 2019
- DOI för Inflammatory and anti-inflammatory markers in plasma: from late pregnancy to early postpartum
- Ladda ner fulltext (pdf) av Inflammatory and anti-inflammatory markers in plasma: from late pregnancy to early postpartum
Circulating microRNA plasma profile in MuSK plus myasthenia gravis
Ingår i Journal of Neuroimmunology, s. 87-91, 2018
Advances in autoimmune myasthenia gravis management
Ingår i Expert Review of Neurotherapeutics, s. 573-588, 2018
Long-Term High-Density Extracellular Recordings Enable Studies of Muscle Cell Physiology
Ingår i Frontiers in Physiology, 2018
- DOI för Long-Term High-Density Extracellular Recordings Enable Studies of Muscle Cell Physiology
- Ladda ner fulltext (pdf) av Long-Term High-Density Extracellular Recordings Enable Studies of Muscle Cell Physiology
Ingår i Journal of Neuroimmunology, s. 164-170, 2018
- DOI för Circulating microRNA miR-21-5p, miR-150-5p and miR-30e-5p correlate with clinical status in late onset myasthenia gravis
- Ladda ner fulltext (pdf) av Circulating microRNA miR-21-5p, miR-150-5p and miR-30e-5p correlate with clinical status in late onset myasthenia gravis
Lifestyle factors and disease-specific differences in subgroups of Swedish Myasthenia Gravis
Ingår i Acta Neurologica Scandinavica, s. 557-565, 2018
Thymectomy lowers the myasthenia gravis biomarker miR-150-5p
Ingår i Neurology, 2018
- DOI för Thymectomy lowers the myasthenia gravis biomarker miR-150-5p
- Ladda ner fulltext (pdf) av Thymectomy lowers the myasthenia gravis biomarker miR-150-5p
Ingår i Medicine, 2018
- DOI för The impact of physical exercise on neuromuscular function in Myasthenia gravis patients: A single-subject design study
- Ladda ner fulltext (pdf) av The impact of physical exercise on neuromuscular function in Myasthenia gravis patients: A single-subject design study
Circulating microRNAs as potential biomarkers in myasthenia gravis patients.
Ingår i Annals of the New York Academy of Sciences, s. 33-40, 2018
High-resistance strength training does not affect nerve cross sectional area – An ultrasound study
Ingår i Clinical Neurophysiology Practice, s. 163-169, 2017
- DOI för High-resistance strength training does not affect nerve cross sectional area – An ultrasound study
- Ladda ner fulltext (pdf) av High-resistance strength training does not affect nerve cross sectional area – An ultrasound study
Ingår i Journal of clinical neurophysiology, s. 400-407, 2017
Ingår i Toxins, 2017
- DOI för Neurophysiological Measures of Efficacy and Safety for Botulinum Toxin Injection in Facial and Bulbar Muscles: Special Considerations
- Ladda ner fulltext (pdf) av Neurophysiological Measures of Efficacy and Safety for Botulinum Toxin Injection in Facial and Bulbar Muscles: Special Considerations
Ingår i Brain and Behavior, 2017
- DOI för Diversity in mental fatigue and social profile of patients with myasthenia gravis in two different Northern European countries
- Ladda ner fulltext (pdf) av Diversity in mental fatigue and social profile of patients with myasthenia gravis in two different Northern European countries
Ingår i Muscle and Nerve, s. 207-214, 2017
Profile of upregulated inflammatory proteins in sera of Myasthenia Gravis patients.
Ingår i Scientific Reports, 2017
- DOI för Profile of upregulated inflammatory proteins in sera of Myasthenia Gravis patients.
- Ladda ner fulltext (pdf) av Profile of upregulated inflammatory proteins in sera of Myasthenia Gravis patients.
Ingår i Clinical Neurophysiology, s. 3480-3484, 2016
Ingår i Dermatologic Surgery, s. 967-976, 2016