Transplantation och regenerativ medicin

Insulinproducerande celler i grönt framtagna från inducerade pluripotenta stamceller. Inväxande blodkärl i rött efter experimentell transplantation till muskel.
Forskningsgruppens övergripande mål är att förhindra utvecklandet av typ I diabetes, och att använda cellterapi för att normalisera glukosomsättningen hos patienter med typ I diabetes.
Forskargruppen är verksam vid såväl institutionen för medicinsk cellbiologi, som institutionen för medicinska vetenskaper, vilket underlättar överföringen av experimentella resultat till klinisk nytta.
Mekanistiska experimentella studier görs för att undersöka bland annat stamcellsframtagna insulinproducerande cellers förmåga att anpassa sig till nya miljöer efter transplantation till olika organ, och hur man kan förbättra transplantatets säkerhet, överlevnad och funktion.
I kliniska studier prövas möjligheten att med cellterapi stoppa upp förlusten av egna insulinproducerande celler vid utveckling av typ 1 diabetes, samt hur insulinproducerande celler kan transplanteras utan samtidigt behov av immunsuppressiv behandling. I andra kliniska studier utvecklas bildanalystekniker för att icke-invasivt kunna följa förändringar i mängden insulinproducerande celler och immunattacken i bukspottkörteln under utveckling av typ 1 diabetes.
Gruppmedlemmar
Publikationer
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Ingår i Diabetes, obesity and metabolism, s. 4876-4883, 2026
- DOI för In vivo imaging of the innate immune system in the pancreas in new-onset and long-standing type 1 diabetes
- Ladda ner fulltext (pdf) av In vivo imaging of the innate immune system in the pancreas in new-onset and long-standing type 1 diabetes
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Ingår i Advanced Science, 2026
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Body-weight-specific and shared metabolomic responses to acute sleep loss in young adults
Ingår i Journal of Translational Medicine, 2026
- DOI för Body-weight-specific and shared metabolomic responses to acute sleep loss in young adults
- Ladda ner fulltext (pdf) av Body-weight-specific and shared metabolomic responses to acute sleep loss in young adults
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Ingår i JIMD Reports, 2026
- DOI för Successful Management of Two Consecutive Pregnancies With Maternal-Fetal Phenylketonuria: Lessons From Clinical Practice
- Ladda ner fulltext (pdf) av Successful Management of Two Consecutive Pregnancies With Maternal-Fetal Phenylketonuria: Lessons From Clinical Practice
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Ingår i Acta Diabetologica, s. 1987-1996, 2025
- DOI för Proximity extension assay inflammatory profiling cannot distinguish the presence of residual C-peptide in patients with long-standing type 1 diabetes
- Ladda ner fulltext (pdf) av Proximity extension assay inflammatory profiling cannot distinguish the presence of residual C-peptide in patients with long-standing type 1 diabetes
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Reflections on The Lancet's Commission on dementia prevention, intervention, and care
Ingår i The Lancet, s. 624-625, 2025
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Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression
Ingår i New England Journal of Medicine, s. 887-894, 2025
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Brain Networks Differ According to Levels of Interference in Spatiotemporal Processing
Ingår i Hippocampus, 2025
- DOI för Brain Networks Differ According to Levels of Interference in Spatiotemporal Processing
- Ladda ner fulltext (pdf) av Brain Networks Differ According to Levels of Interference in Spatiotemporal Processing
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Timing of Antihypertensive Medications and Cardiovascular Outcomes.
Ingår i Journal of the American Medical Association (JAMA), 2025
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Acute Restraint Stress Impairs Aversive Memory Retention but Not Memory Formation
Ingår i Biology, 2025
- DOI för Acute Restraint Stress Impairs Aversive Memory Retention but Not Memory Formation
- Ladda ner fulltext (pdf) av Acute Restraint Stress Impairs Aversive Memory Retention but Not Memory Formation
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Alterations of the pancreas in type 1 diabetes: from prior to diagnosis to long-standing disease
Ingår i Endocrine, s. 140-148, 2025
- DOI för Alterations of the pancreas in type 1 diabetes: from prior to diagnosis to long-standing disease
- Ladda ner fulltext (pdf) av Alterations of the pancreas in type 1 diabetes: from prior to diagnosis to long-standing disease
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Ingår i Scientific Reports, 2025
- DOI för Long-term treatment with gamma-aminobutyric acid (GABA) fails to regain beta-cell function in longstanding type 1 diabetes: results from a randomized trial
- Ladda ner fulltext (pdf) av Long-term treatment with gamma-aminobutyric acid (GABA) fails to regain beta-cell function in longstanding type 1 diabetes: results from a randomized trial
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Ingår i Journal of Diabetes Science and Technology, s. 1515-1527, 2025
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Ingår i Biomarker research, s. 67, 2025
- DOI för The overlooked trio: sleep duration, sampling time and physical exercise alter levels of olink-assessed blood biomarkers of cardiovascular risk.
- Ladda ner fulltext (pdf) av The overlooked trio: sleep duration, sampling time and physical exercise alter levels of olink-assessed blood biomarkers of cardiovascular risk.
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Habitual sleep duration, healthy eating, and digestive system cancer mortality
Ingår i BMC Medicine, 2025
- DOI för Habitual sleep duration, healthy eating, and digestive system cancer mortality
- Ladda ner fulltext (pdf) av Habitual sleep duration, healthy eating, and digestive system cancer mortality
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Bereavement and type 1 diabetes in childhood: a register-based cohort study in Sweden
Ingår i Diabetologia, s. 549-556, 2025
- DOI för Bereavement and type 1 diabetes in childhood: a register-based cohort study in Sweden
- Ladda ner fulltext (pdf) av Bereavement and type 1 diabetes in childhood: a register-based cohort study in Sweden
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Ingår i Journal of Cellular and Molecular Medicine, 2025
- DOI för Acute Sleep Loss Increases Circulating Morning Levels of Two MicroRNAs Implicated in Neurodegenerative Disease in Healthy Young Men
- Ladda ner fulltext (pdf) av Acute Sleep Loss Increases Circulating Morning Levels of Two MicroRNAs Implicated in Neurodegenerative Disease in Healthy Young Men
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Ingår i BMJ Open Diabetes Research & Care, 2024
- DOI för Development of a three-dimensional scoring model for the assessment of continuous glucose monitoring data in type 1 diabetes
- Ladda ner fulltext (pdf) av Development of a three-dimensional scoring model for the assessment of continuous glucose monitoring data in type 1 diabetes
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Outcome after total pancreatectomy with islet autotransplantation: A European single-center study
Ingår i Scandinavian Journal of Surgery, s. 80-87, 2024
- DOI för Outcome after total pancreatectomy with islet autotransplantation: A European single-center study
- Ladda ner fulltext (pdf) av Outcome after total pancreatectomy with islet autotransplantation: A European single-center study
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Predictive biomarkers of rapidly developing insulin deficiency in children with type 1 diabetes
Ingår i BMJ Open Diabetes Research & Care, 2024
- DOI för Predictive biomarkers of rapidly developing insulin deficiency in children with type 1 diabetes
- Ladda ner fulltext (pdf) av Predictive biomarkers of rapidly developing insulin deficiency in children with type 1 diabetes
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PET imaging of GABAA receptors in pancreatic islets by [11C]flumazenil
Ingår i EJNMMI Research, 2024
- DOI för PET imaging of GABAA receptors in pancreatic islets by [11C]flumazenil
- Ladda ner fulltext (pdf) av PET imaging of GABAA receptors in pancreatic islets by [11C]flumazenil
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Habitual Short Sleep Duration, Diet, and Development of Type 2 Diabetes in Adults
Ingår i JAMA Network Open, 2024
- DOI för Habitual Short Sleep Duration, Diet, and Development of Type 2 Diabetes in Adults
- Ladda ner fulltext (pdf) av Habitual Short Sleep Duration, Diet, and Development of Type 2 Diabetes in Adults
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Ingår i American Journal of Clinical Nutrition, s. 121-128, 2024
- DOI för Overfeeding polyunsaturated fat compared to saturated fat does not differentially influence lean tissue accumulation in overweight individuals: a randomized controlled trial
- Ladda ner fulltext (pdf) av Overfeeding polyunsaturated fat compared to saturated fat does not differentially influence lean tissue accumulation in overweight individuals: a randomized controlled trial
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Efficient Vascular and Neural Engraftment of Stem Cell–Derived Islets
Ingår i Diabetes, s. 1127-1139, 2024
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Non-invasive imaging of sympathetic innervation of the pancreas in individuals with type 2 diabetes
Ingår i Diabetologia, s. 199-208, 2024
- DOI för Non-invasive imaging of sympathetic innervation of the pancreas in individuals with type 2 diabetes
- Ladda ner fulltext (pdf) av Non-invasive imaging of sympathetic innervation of the pancreas in individuals with type 2 diabetes
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Ingår i Chest, s. 503-516, 2023
- DOI för OSA Is Associated With the Human Gut Microbiota Composition and Functional Potential in the Population-Based Swedish CardioPulmonary bioImage Study
- Ladda ner fulltext (pdf) av OSA Is Associated With the Human Gut Microbiota Composition and Functional Potential in the Population-Based Swedish CardioPulmonary bioImage Study
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Classification of Hypoglycemic Events in Type 1 Diabetes Using Machine Learning Algorithms
Ingår i Diabetes Therapy, s. 953-965, 2023
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Ingår i Free radical research, s. 460-469, 2023
- DOI för The selective NOX4 inhibitor GLX7013159 decreases blood glucose concentrations and human beta-cell apoptotic rates in diabetic NMRI nu/nu mice transplanted with human islets
- Ladda ner fulltext (pdf) av The selective NOX4 inhibitor GLX7013159 decreases blood glucose concentrations and human beta-cell apoptotic rates in diabetic NMRI nu/nu mice transplanted with human islets
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Ingår i Cell Stem Cell, s. 38-51, 2023
- DOI för An insulin hypersecretion phenotype precedes pancreatic beta cell failure in MODY3 patient-specific cells
- Ladda ner fulltext (pdf) av An insulin hypersecretion phenotype precedes pancreatic beta cell failure in MODY3 patient-specific cells
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Ingår i BMC Medical Informatics and Decision Making, 2023
- DOI för Development and usability evaluation of an electronic health report form to assess health in young people: a mixed-methods approach
- Ladda ner fulltext (pdf) av Development and usability evaluation of an electronic health report form to assess health in young people: a mixed-methods approach
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Ingår i Obesity, s. 1755-1766, 2023
- DOI för Exposure to a more unhealthy diet impacts sleep microstructure during normal sleep and recovery sleep: A randomized trial
- Ladda ner fulltext (pdf) av Exposure to a more unhealthy diet impacts sleep microstructure during normal sleep and recovery sleep: A randomized trial
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A weighted blanket increases pre-sleep salivary concentrations of melatonin in young, healthy adults
Ingår i Journal of Sleep Research, 2023
- DOI för A weighted blanket increases pre-sleep salivary concentrations of melatonin in young, healthy adults
- Ladda ner fulltext (pdf) av A weighted blanket increases pre-sleep salivary concentrations of melatonin in young, healthy adults
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Ingår i Translational Psychiatry, s. 32, 2023
- DOI för Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals.
- Ladda ner fulltext (pdf) av Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals.
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Ingår i Journal of Sleep Research, 2022
- DOI för Acute sleep loss alters circulating fibroblast growth factor 21 levels in humans: A randomised crossover trial.
- Ladda ner fulltext (pdf) av Acute sleep loss alters circulating fibroblast growth factor 21 levels in humans: A randomised crossover trial.
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Pregnancy induces pancreatic insulin secretion in women with long-standing type 1 diabetes
Ingår i BMJ Open Diabetes Research & Care, 2022
- DOI för Pregnancy induces pancreatic insulin secretion in women with long-standing type 1 diabetes
- Ladda ner fulltext (pdf) av Pregnancy induces pancreatic insulin secretion in women with long-standing type 1 diabetes
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Ingår i BMJ Open Diabetes Research & Care, 2022
- DOI för Higher risk of severe hypoglycemia in children and adolescents with a rapid loss of C-peptide during the first 6 years after type 1 diabetes diagnosis
- Ladda ner fulltext (pdf) av Higher risk of severe hypoglycemia in children and adolescents with a rapid loss of C-peptide during the first 6 years after type 1 diabetes diagnosis
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Ingår i International Journal of Developmental Neuroscience, s. 407-422, 2022
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Ingår i Behavioural Pharmacology, s. 575-588, 2022
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Ingår i Frontiers in Nutrition, 2022
- DOI för Association of Daily Eating Duration and Day-To-Day Variability in the Timing of Eating With Fatal Cancer Risk in Older Men
- Ladda ner fulltext (pdf) av Association of Daily Eating Duration and Day-To-Day Variability in the Timing of Eating With Fatal Cancer Risk in Older Men
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Could a good night's sleep improve COVID-19 vaccine efficacy?
Ingår i The Lancet Respiratory Medicine, s. 447-448, 2021
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Ingår i Clocks & Sleep, s. 251-258, 2021
- DOI för Meal and Sleep Timing before and during the COVID-19 Pandemic: A Cross-Sectional Anonymous Survey Study from Sweden
- Ladda ner fulltext (pdf) av Meal and Sleep Timing before and during the COVID-19 Pandemic: A Cross-Sectional Anonymous Survey Study from Sweden
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Ingår i Nature and Science of Sleep, s. 1711-1722, 2021
- DOI för Social Jetlag Changes During the COVID-19 Pandemic as a Predictor of Insomnia - A Multi-National Survey Study
- Ladda ner fulltext (pdf) av Social Jetlag Changes During the COVID-19 Pandemic as a Predictor of Insomnia - A Multi-National Survey Study
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Ingår i Sleep and Breathing, s. 849-860, 2021
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Ingår i Peptides, 2021
- DOI för CART decreases islet blood flow, but has no effect on total pancreatic blood flow and glucose tolerance in anesthetized rats
- Ladda ner fulltext (pdf) av CART decreases islet blood flow, but has no effect on total pancreatic blood flow and glucose tolerance in anesthetized rats
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Pharmacological Inhibition of NOX4 Improves Mitochondrial Function and Survival in Human Beta-Cells
Ingår i Biomedicines, 2021
- DOI för Pharmacological Inhibition of NOX4 Improves Mitochondrial Function and Survival in Human Beta-Cells
- Ladda ner fulltext (pdf) av Pharmacological Inhibition of NOX4 Improves Mitochondrial Function and Survival in Human Beta-Cells
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Longitudinal Assessment of 11C-5-Hydroxytryptophan Uptake in Pancreas After Debut of Type 1 Diabetes
Ingår i Diabetes, s. 966-975, 2021
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GABA induces a hormonal counter-regulatory response in subjects with long-standing type 1 diabetes
Ingår i BMJ Open Diabetes Research & Care, 2021
- DOI för GABA induces a hormonal counter-regulatory response in subjects with long-standing type 1 diabetes
- Ladda ner fulltext (pdf) av GABA induces a hormonal counter-regulatory response in subjects with long-standing type 1 diabetes
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NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding
Ingår i Nature Metabolism, s. 1621-1632, 2021
- DOI för NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding
- Ladda ner fulltext (pdf) av NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding
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Ingår i International Journal of Molecular Sciences, 2021
- DOI för Interleukin-35 Prevents Development of Autoimmune Diabetes Possibly by Maintaining the Phenotype of Regulatory B Cells
- Ladda ner fulltext (pdf) av Interleukin-35 Prevents Development of Autoimmune Diabetes Possibly by Maintaining the Phenotype of Regulatory B Cells
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Ingår i Sleep, 2021
- DOI för Evening-types show highest increase of sleep and mental health problems during the COVID-19 pandemic - Multinational study on 19,267 adults.
- Ladda ner fulltext (pdf) av Evening-types show highest increase of sleep and mental health problems during the COVID-19 pandemic - Multinational study on 19,267 adults.