Transplantation och regenerativ medicin

Insulinproducerande celler i grönt framtagna från inducerade pluripotenta stamceller. Inväxande blodkärl i rött efter experimentell transplantation till muskel.
Forskningsgruppens övergripande mål är att förhindra utvecklandet av typ I diabetes, och att använda cellterapi för att normalisera glukosomsättningen hos patienter med typ I diabetes.
Forskargruppen är verksam vid såväl institutionen för medicinsk cellbiologi, som institutionen för medicinska vetenskaper, vilket underlättar överföringen av experimentella resultat till klinisk nytta.
Mekanistiska experimentella studier görs för att undersöka bland annat stamcellsframtagna insulinproducerande cellers förmåga att anpassa sig till nya miljöer efter transplantation till olika organ, och hur man kan förbättra transplantatets säkerhet, överlevnad och funktion.
I kliniska studier prövas möjligheten att med cellterapi stoppa upp förlusten av egna insulinproducerande celler vid utveckling av typ 1 diabetes, samt hur insulinproducerande celler kan transplanteras utan samtidigt behov av immunsuppressiv behandling. I andra kliniska studier utvecklas bildanalystekniker för att icke-invasivt kunna följa förändringar i mängden insulinproducerande celler och immunattacken i bukspottkörteln under utveckling av typ 1 diabetes.
Publikationer
Habitual sleep duration, healthy eating, and digestive system cancer mortality
Ingår i BMC Medicine, 2025
- DOI för Habitual sleep duration, healthy eating, and digestive system cancer mortality
- Ladda ner fulltext (pdf) av Habitual sleep duration, healthy eating, and digestive system cancer mortality
Ingår i BMJ Open Diabetes Research & Care, 2024
- DOI för Development of a three-dimensional scoring model for the assessment of continuous glucose monitoring data in type 1 diabetes
- Ladda ner fulltext (pdf) av Development of a three-dimensional scoring model for the assessment of continuous glucose monitoring data in type 1 diabetes
Outcome after total pancreatectomy with islet autotransplantation: A European single-center study
Ingår i Scandinavian Journal of Surgery, s. 80-87, 2024
- DOI för Outcome after total pancreatectomy with islet autotransplantation: A European single-center study
- Ladda ner fulltext (pdf) av Outcome after total pancreatectomy with islet autotransplantation: A European single-center study
Predictive biomarkers of rapidly developing insulin deficiency in children with type 1 diabetes
Ingår i BMJ Open Diabetes Research & Care, 2024
- DOI för Predictive biomarkers of rapidly developing insulin deficiency in children with type 1 diabetes
- Ladda ner fulltext (pdf) av Predictive biomarkers of rapidly developing insulin deficiency in children with type 1 diabetes
PET imaging of GABAA receptors in pancreatic islets by [11C]flumazenil
Ingår i EJNMMI Research, 2024
- DOI för PET imaging of GABAA receptors in pancreatic islets by [11C]flumazenil
- Ladda ner fulltext (pdf) av PET imaging of GABAA receptors in pancreatic islets by [11C]flumazenil
Habitual Short Sleep Duration, Diet, and Development of Type 2 Diabetes in Adults
Ingår i JAMA Network Open, 2024
- DOI för Habitual Short Sleep Duration, Diet, and Development of Type 2 Diabetes in Adults
- Ladda ner fulltext (pdf) av Habitual Short Sleep Duration, Diet, and Development of Type 2 Diabetes in Adults
Ingår i American Journal of Clinical Nutrition, s. 121-128, 2024
- DOI för Overfeeding polyunsaturated fat compared to saturated fat does not differentially influence lean tissue accumulation in overweight individuals: a randomized controlled trial
- Ladda ner fulltext (pdf) av Overfeeding polyunsaturated fat compared to saturated fat does not differentially influence lean tissue accumulation in overweight individuals: a randomized controlled trial
Efficient Vascular and Neural Engraftment of Stem Cell–Derived Islets
Ingår i Diabetes, s. 1127-1139, 2024
Non-invasive imaging of sympathetic innervation of the pancreas in individuals with type 2 diabetes
Ingår i Diabetologia, s. 199-208, 2024
- DOI för Non-invasive imaging of sympathetic innervation of the pancreas in individuals with type 2 diabetes
- Ladda ner fulltext (pdf) av Non-invasive imaging of sympathetic innervation of the pancreas in individuals with type 2 diabetes
Bereavement and type 1 diabetes in childhood: a register-based cohort study in Sweden.
Ingår i Diabetologia, 2024
Ingår i Chest, s. 503-516, 2023
- DOI för OSA Is Associated With the Human Gut Microbiota Composition and Functional Potential in the Population-Based Swedish CardioPulmonary bioImage Study
- Ladda ner fulltext (pdf) av OSA Is Associated With the Human Gut Microbiota Composition and Functional Potential in the Population-Based Swedish CardioPulmonary bioImage Study
Classification of Hypoglycemic Events in Type 1 Diabetes Using Machine Learning Algorithms
Ingår i Diabetes Therapy, s. 953-965, 2023
Ingår i Free radical research, s. 460-469, 2023
- DOI för The selective NOX4 inhibitor GLX7013159 decreases blood glucose concentrations and human beta-cell apoptotic rates in diabetic NMRI nu/nu mice transplanted with human islets
- Ladda ner fulltext (pdf) av The selective NOX4 inhibitor GLX7013159 decreases blood glucose concentrations and human beta-cell apoptotic rates in diabetic NMRI nu/nu mice transplanted with human islets
Ingår i Cell Stem Cell, s. 38-51, 2023
- DOI för An insulin hypersecretion phenotype precedes pancreatic beta cell failure in MODY3 patient-specific cells
- Ladda ner fulltext (pdf) av An insulin hypersecretion phenotype precedes pancreatic beta cell failure in MODY3 patient-specific cells
Ingår i BMC Medical Informatics and Decision Making, 2023
- DOI för Development and usability evaluation of an electronic health report form to assess health in young people: a mixed-methods approach
- Ladda ner fulltext (pdf) av Development and usability evaluation of an electronic health report form to assess health in young people: a mixed-methods approach
Ingår i Obesity, s. 1755-1766, 2023
- DOI för Exposure to a more unhealthy diet impacts sleep microstructure during normal sleep and recovery sleep: A randomized trial
- Ladda ner fulltext (pdf) av Exposure to a more unhealthy diet impacts sleep microstructure during normal sleep and recovery sleep: A randomized trial
A weighted blanket increases pre-sleep salivary concentrations of melatonin in young, healthy adults
Ingår i Journal of Sleep Research, 2023
- DOI för A weighted blanket increases pre-sleep salivary concentrations of melatonin in young, healthy adults
- Ladda ner fulltext (pdf) av A weighted blanket increases pre-sleep salivary concentrations of melatonin in young, healthy adults
Ingår i Translational Psychiatry, s. 32, 2023
- DOI för Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals.
- Ladda ner fulltext (pdf) av Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals.
Ingår i Journal of Sleep Research, 2022
- DOI för Acute sleep loss alters circulating fibroblast growth factor 21 levels in humans: A randomised crossover trial.
- Ladda ner fulltext (pdf) av Acute sleep loss alters circulating fibroblast growth factor 21 levels in humans: A randomised crossover trial.
Pregnancy induces pancreatic insulin secretion in women with long-standing type 1 diabetes
Ingår i BMJ Open Diabetes Research & Care, 2022
- DOI för Pregnancy induces pancreatic insulin secretion in women with long-standing type 1 diabetes
- Ladda ner fulltext (pdf) av Pregnancy induces pancreatic insulin secretion in women with long-standing type 1 diabetes
Ingår i BMJ Open Diabetes Research & Care, 2022
- DOI för Higher risk of severe hypoglycemia in children and adolescents with a rapid loss of C-peptide during the first 6 years after type 1 diabetes diagnosis
- Ladda ner fulltext (pdf) av Higher risk of severe hypoglycemia in children and adolescents with a rapid loss of C-peptide during the first 6 years after type 1 diabetes diagnosis
Ingår i International Journal of Developmental Neuroscience, s. 407-422, 2022
Ingår i Behavioural Pharmacology, s. 575-588, 2022
Ingår i Frontiers in Nutrition, 2022
- DOI för Association of Daily Eating Duration and Day-To-Day Variability in the Timing of Eating With Fatal Cancer Risk in Older Men
- Ladda ner fulltext (pdf) av Association of Daily Eating Duration and Day-To-Day Variability in the Timing of Eating With Fatal Cancer Risk in Older Men
Ingår i JMIR Diabetes, 2022
Could a good night's sleep improve COVID-19 vaccine efficacy?
Ingår i The Lancet Respiratory Medicine, s. 447-448, 2021
Ingår i Clocks & Sleep, s. 251-258, 2021
- DOI för Meal and Sleep Timing before and during the COVID-19 Pandemic: A Cross-Sectional Anonymous Survey Study from Sweden
- Ladda ner fulltext (pdf) av Meal and Sleep Timing before and during the COVID-19 Pandemic: A Cross-Sectional Anonymous Survey Study from Sweden
Ingår i Nature and Science of Sleep, s. 1711-1722, 2021
- DOI för Social Jetlag Changes During the COVID-19 Pandemic as a Predictor of Insomnia - A Multi-National Survey Study
- Ladda ner fulltext (pdf) av Social Jetlag Changes During the COVID-19 Pandemic as a Predictor of Insomnia - A Multi-National Survey Study
Ingår i Sleep and Breathing, s. 849-860, 2021
Ingår i Peptides, 2021
- DOI för CART decreases islet blood flow, but has no effect on total pancreatic blood flow and glucose tolerance in anesthetized rats
- Ladda ner fulltext (pdf) av CART decreases islet blood flow, but has no effect on total pancreatic blood flow and glucose tolerance in anesthetized rats
Pharmacological Inhibition of NOX4 Improves Mitochondrial Function and Survival in Human Beta-Cells
Ingår i Biomedicines, 2021
- DOI för Pharmacological Inhibition of NOX4 Improves Mitochondrial Function and Survival in Human Beta-Cells
- Ladda ner fulltext (pdf) av Pharmacological Inhibition of NOX4 Improves Mitochondrial Function and Survival in Human Beta-Cells
Longitudinal Assessment of 11C-5-Hydroxytryptophan Uptake in Pancreas After Debut of Type 1 Diabetes
Ingår i Diabetes, s. 966-975, 2021
GABA induces a hormonal counter-regulatory response in subjects with long-standing type 1 diabetes
Ingår i BMJ Open Diabetes Research & Care, 2021
- DOI för GABA induces a hormonal counter-regulatory response in subjects with long-standing type 1 diabetes
- Ladda ner fulltext (pdf) av GABA induces a hormonal counter-regulatory response in subjects with long-standing type 1 diabetes
NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding
Ingår i Nature Metabolism, s. 1621-1632, 2021
- DOI för NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding
- Ladda ner fulltext (pdf) av NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding
Ingår i International Journal of Molecular Sciences, 2021
- DOI för Interleukin-35 Prevents Development of Autoimmune Diabetes Possibly by Maintaining the Phenotype of Regulatory B Cells
- Ladda ner fulltext (pdf) av Interleukin-35 Prevents Development of Autoimmune Diabetes Possibly by Maintaining the Phenotype of Regulatory B Cells
Ingår i Sleep, 2021
- DOI för Evening-types show highest increase of sleep and mental health problems during the COVID-19 pandemic - Multinational study on 19,267 adults.
- Ladda ner fulltext (pdf) av Evening-types show highest increase of sleep and mental health problems during the COVID-19 pandemic - Multinational study on 19,267 adults.
Insomnia, anxiety, and depression during the COVID-19 pandemic: an international collaborative study
Ingår i Sleep Medicine, s. 38-45, 2021
Gut microbiome as a therapeutic target in the treatment of sleep disorders: where we are
Ingår i Sleep Medicine Reviews, 2021
Ingår i BMJ Open, 2021
- DOI för Sleep and daytime problems during the COVID-19 pandemic and effects of coronavirus infection, confinement and financial suffering: a multinational survey using a harmonised questionnaire
- Ladda ner fulltext (pdf) av Sleep and daytime problems during the COVID-19 pandemic and effects of coronavirus infection, confinement and financial suffering: a multinational survey using a harmonised questionnaire
Ingår i International Journal of Developmental Neuroscience, s. 616-632, 2021
Effects of acute sleep loss on diurnal plasma dynamics of CNS health biomarkers in young men
Ingår i Neurology, 2020
- DOI för Effects of acute sleep loss on diurnal plasma dynamics of CNS health biomarkers in young men
- Ladda ner fulltext (pdf) av Effects of acute sleep loss on diurnal plasma dynamics of CNS health biomarkers in young men
Function and Gene Expression of Islets Experimentally Transplanted to Muscle and Omentum
Ingår i Cell Transplantation, s. 1-10, 2020
- DOI för Function and Gene Expression of Islets Experimentally Transplanted to Muscle and Omentum
- Ladda ner fulltext (pdf) av Function and Gene Expression of Islets Experimentally Transplanted to Muscle and Omentum
Ingår i BMJ Open Diabetes Research & Care, 2020
- DOI för Better HbA1c during the first years after diagnosis of type 1 diabetes is associated with residual C peptide 10 years later
- Ladda ner fulltext (pdf) av Better HbA1c during the first years after diagnosis of type 1 diabetes is associated with residual C peptide 10 years later
Ingår i Journal of Clinical Endocrinology and Metabolism, 2020
- DOI för Physical Activity, Genetic Susceptibility, and the Risk of Latent Autoimmune Diabetes in Adults and Type 2 Diabetes
- Ladda ner fulltext (pdf) av Physical Activity, Genetic Susceptibility, and the Risk of Latent Autoimmune Diabetes in Adults and Type 2 Diabetes
NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging
Ingår i Molecular Cell, s. 835-+, 2020
Ingår i Frontiers in Immunology, 2020
- DOI för Mass Cytometry Studies of Patients With Autoimmune Endocrine Diseases Reveal Distinct Disease-Specific Alterations in Immune Cell Subsets
- Ladda ner fulltext (pdf) av Mass Cytometry Studies of Patients With Autoimmune Endocrine Diseases Reveal Distinct Disease-Specific Alterations in Immune Cell Subsets
Ingår i Frontiers in Nutrition, 2020
- DOI för Abdominal Fat and Metabolic Health Markers but Not PNPLA3 Genotype Predicts Liver Fat Accumulation in Response to Excess Intake of Energy and Saturated Fat in Healthy Individuals
- Ladda ner fulltext (pdf) av Abdominal Fat and Metabolic Health Markers but Not PNPLA3 Genotype Predicts Liver Fat Accumulation in Response to Excess Intake of Energy and Saturated Fat in Healthy Individuals
Ingår i Scientific Reports, 2020
- DOI för Self-reported difficulty initiating sleep and early morning awakenings are associated with nocturnal diastolic non-dipping in older white Swedish men
- Ladda ner fulltext (pdf) av Self-reported difficulty initiating sleep and early morning awakenings are associated with nocturnal diastolic non-dipping in older white Swedish men
Ingår i Physiological Reports, 2020
- DOI för Highly blood perfused, highly metabolically active pancreatic islets may be more susceptible for immune attack
- Ladda ner fulltext (pdf) av Highly blood perfused, highly metabolically active pancreatic islets may be more susceptible for immune attack
An epigenetic clock for human skeletal muscle
Ingår i Journal of Cachexia, Sarcopenia and Muscle, s. 887-898, 2020
- DOI för An epigenetic clock for human skeletal muscle
- Ladda ner fulltext (pdf) av An epigenetic clock for human skeletal muscle