Transplantation and Regenerative Medicine

Insulin-producing cells in green together with growing blood vessels in red after experimental transplantation to muscle.

Insulin-producing cells in green derived from induced pluripotent stem cells. Growing blood vessels in red after experimental transplantation to muscle.

The overall goal of the research group is to prevent the development of type I diabetes, and to use cell therapy to normalise glucose metabolism in patients with type I diabetes.

The research group is located at both the Department of Medical Cell Biology and the Depart­ment of Medical Sciences, which facilitates the transfer of experi­mental results to clinical use.

Mechanistic experi­mental studies are conducted to investi­gate, among other things, the ability of stem cell-derived insulin-producing cells to adapt to new environ­ments after trans­plan­tation to different organs, and how to improve the safety, survival and function of the graft.

Clinical studies are testing the possibility of using cell therapy to stop the loss of own insulin-producing cells in the develop­ment of type 1 diabetes, and how insulin-producing cells can be trans­planted without the need for immuno­suppressive treat­ment. Other clinical studies are deve­loping image analysis tech­niques to non-invasively monitor changes in the number of insulin-producing cells and the immune attack in the pancreas during the deve­lopment of type 1 diabetes.

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