Transplantation and Regenerative Medicine

Insulin-producing cells in green derived from induced pluripotent stem cells. Growing blood vessels in red after experimental transplantation to muscle.
The overall goal of the research group is to prevent the development of type I diabetes, and to use cell therapy to normalise glucose metabolism in patients with type I diabetes.
The research group is located at both the Department of Medical Cell Biology and the Department of Medical Sciences, which facilitates the transfer of experimental results to clinical use.
Mechanistic experimental studies are conducted to investigate, among other things, the ability of stem cell-derived insulin-producing cells to adapt to new environments after transplantation to different organs, and how to improve the safety, survival and function of the graft.
Clinical studies are testing the possibility of using cell therapy to stop the loss of own insulin-producing cells in the development of type 1 diabetes, and how insulin-producing cells can be transplanted without the need for immunosuppressive treatment. Other clinical studies are developing image analysis techniques to non-invasively monitor changes in the number of insulin-producing cells and the immune attack in the pancreas during the development of type 1 diabetes.
Gruppmedlemmar
Publications
-
Part of Diabetes, obesity and metabolism, p. 4876-4883, 2026
- DOI for In vivo imaging of the innate immune system in the pancreas in new-onset and long-standing type 1 diabetes
- Download full text (pdf) of In vivo imaging of the innate immune system in the pancreas in new-onset and long-standing type 1 diabetes
-
Part of Advanced Science, 2026
-
Body-weight-specific and shared metabolomic responses to acute sleep loss in young adults
Part of Journal of Translational Medicine, 2026
- DOI for Body-weight-specific and shared metabolomic responses to acute sleep loss in young adults
- Download full text (pdf) of Body-weight-specific and shared metabolomic responses to acute sleep loss in young adults
-
Part of JIMD Reports, 2026
- DOI for Successful Management of Two Consecutive Pregnancies With Maternal-Fetal Phenylketonuria: Lessons From Clinical Practice
- Download full text (pdf) of Successful Management of Two Consecutive Pregnancies With Maternal-Fetal Phenylketonuria: Lessons From Clinical Practice
-
Part of Acta Diabetologica, p. 1987-1996, 2025
- DOI for Proximity extension assay inflammatory profiling cannot distinguish the presence of residual C-peptide in patients with long-standing type 1 diabetes
- Download full text (pdf) of Proximity extension assay inflammatory profiling cannot distinguish the presence of residual C-peptide in patients with long-standing type 1 diabetes
-
Reflections on The Lancet's Commission on dementia prevention, intervention, and care
Part of The Lancet, p. 624-625, 2025
-
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression
Part of New England Journal of Medicine, p. 887-894, 2025
-
Brain Networks Differ According to Levels of Interference in Spatiotemporal Processing
Part of Hippocampus, 2025
- DOI for Brain Networks Differ According to Levels of Interference in Spatiotemporal Processing
- Download full text (pdf) of Brain Networks Differ According to Levels of Interference in Spatiotemporal Processing
-
Timing of Antihypertensive Medications and Cardiovascular Outcomes.
Part of Journal of the American Medical Association (JAMA), 2025
-
Acute Restraint Stress Impairs Aversive Memory Retention but Not Memory Formation
Part of Biology, 2025
- DOI for Acute Restraint Stress Impairs Aversive Memory Retention but Not Memory Formation
- Download full text (pdf) of Acute Restraint Stress Impairs Aversive Memory Retention but Not Memory Formation
-
Alterations of the pancreas in type 1 diabetes: from prior to diagnosis to long-standing disease
Part of Endocrine, p. 140-148, 2025
- DOI for Alterations of the pancreas in type 1 diabetes: from prior to diagnosis to long-standing disease
- Download full text (pdf) of Alterations of the pancreas in type 1 diabetes: from prior to diagnosis to long-standing disease
-
Part of Scientific Reports, 2025
- DOI for Long-term treatment with gamma-aminobutyric acid (GABA) fails to regain beta-cell function in longstanding type 1 diabetes: results from a randomized trial
- Download full text (pdf) of Long-term treatment with gamma-aminobutyric acid (GABA) fails to regain beta-cell function in longstanding type 1 diabetes: results from a randomized trial
-
Part of Journal of Diabetes Science and Technology, p. 1515-1527, 2025
-
Part of Biomarker research, p. 67, 2025
- DOI for The overlooked trio: sleep duration, sampling time and physical exercise alter levels of olink-assessed blood biomarkers of cardiovascular risk.
- Download full text (pdf) of The overlooked trio: sleep duration, sampling time and physical exercise alter levels of olink-assessed blood biomarkers of cardiovascular risk.
-
Habitual sleep duration, healthy eating, and digestive system cancer mortality
Part of BMC Medicine, 2025
- DOI for Habitual sleep duration, healthy eating, and digestive system cancer mortality
- Download full text (pdf) of Habitual sleep duration, healthy eating, and digestive system cancer mortality
-
Bereavement and type 1 diabetes in childhood: a register-based cohort study in Sweden
Part of Diabetologia, p. 549-556, 2025
- DOI for Bereavement and type 1 diabetes in childhood: a register-based cohort study in Sweden
- Download full text (pdf) of Bereavement and type 1 diabetes in childhood: a register-based cohort study in Sweden
-
Part of Journal of Cellular and Molecular Medicine, 2025
- DOI for Acute Sleep Loss Increases Circulating Morning Levels of Two MicroRNAs Implicated in Neurodegenerative Disease in Healthy Young Men
- Download full text (pdf) of Acute Sleep Loss Increases Circulating Morning Levels of Two MicroRNAs Implicated in Neurodegenerative Disease in Healthy Young Men
-
Part of BMJ Open Diabetes Research & Care, 2024
- DOI for Development of a three-dimensional scoring model for the assessment of continuous glucose monitoring data in type 1 diabetes
- Download full text (pdf) of Development of a three-dimensional scoring model for the assessment of continuous glucose monitoring data in type 1 diabetes
-
Outcome after total pancreatectomy with islet autotransplantation: A European single-center study
Part of Scandinavian Journal of Surgery, p. 80-87, 2024
- DOI for Outcome after total pancreatectomy with islet autotransplantation: A European single-center study
- Download full text (pdf) of Outcome after total pancreatectomy with islet autotransplantation: A European single-center study
-
Predictive biomarkers of rapidly developing insulin deficiency in children with type 1 diabetes
Part of BMJ Open Diabetes Research & Care, 2024
- DOI for Predictive biomarkers of rapidly developing insulin deficiency in children with type 1 diabetes
- Download full text (pdf) of Predictive biomarkers of rapidly developing insulin deficiency in children with type 1 diabetes
-
PET imaging of GABAA receptors in pancreatic islets by [11C]flumazenil
Part of EJNMMI Research, 2024
- DOI for PET imaging of GABAA receptors in pancreatic islets by [11C]flumazenil
- Download full text (pdf) of PET imaging of GABAA receptors in pancreatic islets by [11C]flumazenil
-
Habitual Short Sleep Duration, Diet, and Development of Type 2 Diabetes in Adults
Part of JAMA Network Open, 2024
- DOI for Habitual Short Sleep Duration, Diet, and Development of Type 2 Diabetes in Adults
- Download full text (pdf) of Habitual Short Sleep Duration, Diet, and Development of Type 2 Diabetes in Adults
-
Part of American Journal of Clinical Nutrition, p. 121-128, 2024
- DOI for Overfeeding polyunsaturated fat compared to saturated fat does not differentially influence lean tissue accumulation in overweight individuals: a randomized controlled trial
- Download full text (pdf) of Overfeeding polyunsaturated fat compared to saturated fat does not differentially influence lean tissue accumulation in overweight individuals: a randomized controlled trial
-
Efficient Vascular and Neural Engraftment of Stem Cell–Derived Islets
Part of Diabetes, p. 1127-1139, 2024
-
Non-invasive imaging of sympathetic innervation of the pancreas in individuals with type 2 diabetes
Part of Diabetologia, p. 199-208, 2024
- DOI for Non-invasive imaging of sympathetic innervation of the pancreas in individuals with type 2 diabetes
- Download full text (pdf) of Non-invasive imaging of sympathetic innervation of the pancreas in individuals with type 2 diabetes
-
Part of Chest, p. 503-516, 2023
- DOI for OSA Is Associated With the Human Gut Microbiota Composition and Functional Potential in the Population-Based Swedish CardioPulmonary bioImage Study
- Download full text (pdf) of OSA Is Associated With the Human Gut Microbiota Composition and Functional Potential in the Population-Based Swedish CardioPulmonary bioImage Study
-
Classification of Hypoglycemic Events in Type 1 Diabetes Using Machine Learning Algorithms
Part of Diabetes Therapy, p. 953-965, 2023
-
Part of Free radical research, p. 460-469, 2023
- DOI for The selective NOX4 inhibitor GLX7013159 decreases blood glucose concentrations and human beta-cell apoptotic rates in diabetic NMRI nu/nu mice transplanted with human islets
- Download full text (pdf) of The selective NOX4 inhibitor GLX7013159 decreases blood glucose concentrations and human beta-cell apoptotic rates in diabetic NMRI nu/nu mice transplanted with human islets
-
Part of Cell Stem Cell, p. 38-51, 2023
- DOI for An insulin hypersecretion phenotype precedes pancreatic beta cell failure in MODY3 patient-specific cells
- Download full text (pdf) of An insulin hypersecretion phenotype precedes pancreatic beta cell failure in MODY3 patient-specific cells
-
Part of BMC Medical Informatics and Decision Making, 2023
- DOI for Development and usability evaluation of an electronic health report form to assess health in young people: a mixed-methods approach
- Download full text (pdf) of Development and usability evaluation of an electronic health report form to assess health in young people: a mixed-methods approach
-
Part of Obesity, p. 1755-1766, 2023
- DOI for Exposure to a more unhealthy diet impacts sleep microstructure during normal sleep and recovery sleep: A randomized trial
- Download full text (pdf) of Exposure to a more unhealthy diet impacts sleep microstructure during normal sleep and recovery sleep: A randomized trial
-
A weighted blanket increases pre-sleep salivary concentrations of melatonin in young, healthy adults
Part of Journal of Sleep Research, 2023
- DOI for A weighted blanket increases pre-sleep salivary concentrations of melatonin in young, healthy adults
- Download full text (pdf) of A weighted blanket increases pre-sleep salivary concentrations of melatonin in young, healthy adults
-
Part of Translational Psychiatry, p. 32, 2023
- DOI for Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals.
- Download full text (pdf) of Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals.
-
Part of Journal of Sleep Research, 2022
- DOI for Acute sleep loss alters circulating fibroblast growth factor 21 levels in humans: A randomised crossover trial.
- Download full text (pdf) of Acute sleep loss alters circulating fibroblast growth factor 21 levels in humans: A randomised crossover trial.
-
Pregnancy induces pancreatic insulin secretion in women with long-standing type 1 diabetes
Part of BMJ Open Diabetes Research & Care, 2022
- DOI for Pregnancy induces pancreatic insulin secretion in women with long-standing type 1 diabetes
- Download full text (pdf) of Pregnancy induces pancreatic insulin secretion in women with long-standing type 1 diabetes
-
Part of BMJ Open Diabetes Research & Care, 2022
- DOI for Higher risk of severe hypoglycemia in children and adolescents with a rapid loss of C-peptide during the first 6 years after type 1 diabetes diagnosis
- Download full text (pdf) of Higher risk of severe hypoglycemia in children and adolescents with a rapid loss of C-peptide during the first 6 years after type 1 diabetes diagnosis
-
Part of International Journal of Developmental Neuroscience, p. 407-422, 2022
-
Part of Behavioural Pharmacology, p. 575-588, 2022
-
Part of Frontiers in Nutrition, 2022
- DOI for Association of Daily Eating Duration and Day-To-Day Variability in the Timing of Eating With Fatal Cancer Risk in Older Men
- Download full text (pdf) of Association of Daily Eating Duration and Day-To-Day Variability in the Timing of Eating With Fatal Cancer Risk in Older Men
-
Could a good night's sleep improve COVID-19 vaccine efficacy?
Part of The Lancet Respiratory Medicine, p. 447-448, 2021
-
Part of Clocks & Sleep, p. 251-258, 2021
- DOI for Meal and Sleep Timing before and during the COVID-19 Pandemic: A Cross-Sectional Anonymous Survey Study from Sweden
- Download full text (pdf) of Meal and Sleep Timing before and during the COVID-19 Pandemic: A Cross-Sectional Anonymous Survey Study from Sweden
-
Part of Nature and Science of Sleep, p. 1711-1722, 2021
- DOI for Social Jetlag Changes During the COVID-19 Pandemic as a Predictor of Insomnia - A Multi-National Survey Study
- Download full text (pdf) of Social Jetlag Changes During the COVID-19 Pandemic as a Predictor of Insomnia - A Multi-National Survey Study
-
Part of Sleep and Breathing, p. 849-860, 2021
-
Part of Peptides, 2021
- DOI for CART decreases islet blood flow, but has no effect on total pancreatic blood flow and glucose tolerance in anesthetized rats
- Download full text (pdf) of CART decreases islet blood flow, but has no effect on total pancreatic blood flow and glucose tolerance in anesthetized rats
-
Pharmacological Inhibition of NOX4 Improves Mitochondrial Function and Survival in Human Beta-Cells
Part of Biomedicines, 2021
- DOI for Pharmacological Inhibition of NOX4 Improves Mitochondrial Function and Survival in Human Beta-Cells
- Download full text (pdf) of Pharmacological Inhibition of NOX4 Improves Mitochondrial Function and Survival in Human Beta-Cells
-
Longitudinal Assessment of 11C-5-Hydroxytryptophan Uptake in Pancreas After Debut of Type 1 Diabetes
Part of Diabetes, p. 966-975, 2021
-
GABA induces a hormonal counter-regulatory response in subjects with long-standing type 1 diabetes
Part of BMJ Open Diabetes Research & Care, 2021
- DOI for GABA induces a hormonal counter-regulatory response in subjects with long-standing type 1 diabetes
- Download full text (pdf) of GABA induces a hormonal counter-regulatory response in subjects with long-standing type 1 diabetes
-
NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding
Part of Nature Metabolism, p. 1621-1632, 2021
- DOI for NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding
- Download full text (pdf) of NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding
-
Part of International Journal of Molecular Sciences, 2021
- DOI for Interleukin-35 Prevents Development of Autoimmune Diabetes Possibly by Maintaining the Phenotype of Regulatory B Cells
- Download full text (pdf) of Interleukin-35 Prevents Development of Autoimmune Diabetes Possibly by Maintaining the Phenotype of Regulatory B Cells
-
Part of Sleep, 2021
- DOI for Evening-types show highest increase of sleep and mental health problems during the COVID-19 pandemic - Multinational study on 19,267 adults.
- Download full text (pdf) of Evening-types show highest increase of sleep and mental health problems during the COVID-19 pandemic - Multinational study on 19,267 adults.