Daniel Espes
Senior Lecturer/Associate Professor at Department of Medical Cell Biology; Research group Daniel Espes
- E-mail:
- daniel.espes@mcb.uu.se
- Visiting address:
- BMC
Husargatan 3
751 23 Uppsala - Postal address:
- Box 571
751 23 UPPSALA
Associate senior lecturer/Assistant Professor at Department of Medical Sciences; Transplantation and regenerative medicine
- E-mail:
- daniel.espes@scilifelab.uu.se
- Visiting address:
- Akademiska sjukhuset, ingång 40, 5 tr
751 85 Uppsala - Postal address:
- Akademiska sjukhuset, Ingång 40, 5 tr
751 85 UPPSALA

Publications
Recent publications
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Part of Diabetes, obesity and metabolism, p. 4876-4883, 2026
- DOI for In vivo imaging of the innate immune system in the pancreas in new-onset and long-standing type 1 diabetes
- Download full text (pdf) of In vivo imaging of the innate immune system in the pancreas in new-onset and long-standing type 1 diabetes
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Part of Clinical Case Reports, 2026
- DOI for Two Patients With Extremely Long Type 1 Diabetes Duration With Very Few Complications and Remaining Insulin Secretion
- Download full text (pdf) of Two Patients With Extremely Long Type 1 Diabetes Duration With Very Few Complications and Remaining Insulin Secretion
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Part of Acta Diabetologica, p. 1987-1996, 2025
- DOI for Proximity extension assay inflammatory profiling cannot distinguish the presence of residual C-peptide in patients with long-standing type 1 diabetes
- Download full text (pdf) of Proximity extension assay inflammatory profiling cannot distinguish the presence of residual C-peptide in patients with long-standing type 1 diabetes
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Part of Journal of Diabetes Science and Technology, p. 1515-1527, 2025
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Alterations of the pancreas in type 1 diabetes: from prior to diagnosis to long-standing disease
Part of Endocrine, p. 140-148, 2025
- DOI for Alterations of the pancreas in type 1 diabetes: from prior to diagnosis to long-standing disease
- Download full text (pdf) of Alterations of the pancreas in type 1 diabetes: from prior to diagnosis to long-standing disease
All publications
Articles in journal
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Part of Diabetes, obesity and metabolism, p. 4876-4883, 2026
- DOI for In vivo imaging of the innate immune system in the pancreas in new-onset and long-standing type 1 diabetes
- Download full text (pdf) of In vivo imaging of the innate immune system in the pancreas in new-onset and long-standing type 1 diabetes
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Part of Clinical Case Reports, 2026
- DOI for Two Patients With Extremely Long Type 1 Diabetes Duration With Very Few Complications and Remaining Insulin Secretion
- Download full text (pdf) of Two Patients With Extremely Long Type 1 Diabetes Duration With Very Few Complications and Remaining Insulin Secretion
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Part of Acta Diabetologica, p. 1987-1996, 2025
- DOI for Proximity extension assay inflammatory profiling cannot distinguish the presence of residual C-peptide in patients with long-standing type 1 diabetes
- Download full text (pdf) of Proximity extension assay inflammatory profiling cannot distinguish the presence of residual C-peptide in patients with long-standing type 1 diabetes
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Part of Journal of Diabetes Science and Technology, p. 1515-1527, 2025
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Alterations of the pancreas in type 1 diabetes: from prior to diagnosis to long-standing disease
Part of Endocrine, p. 140-148, 2025
- DOI for Alterations of the pancreas in type 1 diabetes: from prior to diagnosis to long-standing disease
- Download full text (pdf) of Alterations of the pancreas in type 1 diabetes: from prior to diagnosis to long-standing disease
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Part of Communications Biology, 2025
- DOI for Chromogranin A and catestatin regulate pancreatic islet homeostasis, endocrine function, and neurotransmitter signaling
- Download full text (pdf) of Chromogranin A and catestatin regulate pancreatic islet homeostasis, endocrine function, and neurotransmitter signaling
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Part of Biomarker research, p. 67, 2025
- DOI for The overlooked trio: sleep duration, sampling time and physical exercise alter levels of olink-assessed blood biomarkers of cardiovascular risk.
- Download full text (pdf) of The overlooked trio: sleep duration, sampling time and physical exercise alter levels of olink-assessed blood biomarkers of cardiovascular risk.
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Part of Scientific Reports, 2025
- DOI for Long-term treatment with gamma-aminobutyric acid (GABA) fails to regain beta-cell function in longstanding type 1 diabetes: results from a randomized trial
- Download full text (pdf) of Long-term treatment with gamma-aminobutyric acid (GABA) fails to regain beta-cell function in longstanding type 1 diabetes: results from a randomized trial
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Part of BMJ Open Diabetes Research & Care, 2024
- DOI for Development of a three-dimensional scoring model for the assessment of continuous glucose monitoring data in type 1 diabetes
- Download full text (pdf) of Development of a three-dimensional scoring model for the assessment of continuous glucose monitoring data in type 1 diabetes
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PET imaging of GABAA receptors in pancreatic islets by [11C]flumazenil
Part of EJNMMI Research, 2024
- DOI for PET imaging of GABAA receptors in pancreatic islets by [11C]flumazenil
- Download full text (pdf) of PET imaging of GABAA receptors in pancreatic islets by [11C]flumazenil
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Non-invasive imaging of sympathetic innervation of the pancreas in individuals with type 2 diabetes
Part of Diabetologia, p. 199-208, 2024
- DOI for Non-invasive imaging of sympathetic innervation of the pancreas in individuals with type 2 diabetes
- Download full text (pdf) of Non-invasive imaging of sympathetic innervation of the pancreas in individuals with type 2 diabetes
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Predictive biomarkers of rapidly developing insulin deficiency in children with type 1 diabetes
Part of BMJ Open Diabetes Research & Care, 2024
- DOI for Predictive biomarkers of rapidly developing insulin deficiency in children with type 1 diabetes
- Download full text (pdf) of Predictive biomarkers of rapidly developing insulin deficiency in children with type 1 diabetes
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Real-life data of hypoglycemic events in children and adolescents with type 1 diabetes
Part of BMJ Open Diabetes Research & Care, 2023
- DOI for Real-life data of hypoglycemic events in children and adolescents with type 1 diabetes
- Download full text (pdf) of Real-life data of hypoglycemic events in children and adolescents with type 1 diabetes
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Classification of Hypoglycemic Events in Type 1 Diabetes Using Machine Learning Algorithms
Part of Diabetes Therapy, p. 953-965, 2023
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Part of Diabetologia, p. 1431-1441, 2023
- DOI for Umbilical cord-derived mesenchymal stromal cells preserve endogenous insulin production in type 1 diabetes: a Phase I/II randomised double-blind placebo-controlled trial
- Download full text (pdf) of Umbilical cord-derived mesenchymal stromal cells preserve endogenous insulin production in type 1 diabetes: a Phase I/II randomised double-blind placebo-controlled trial
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Part of Biomedicines, 2022
- DOI for Endogenous Levels of Gamma Amino-Butyric Acid Are Correlated to Glutamic-Acid Decarboxylase Antibody Levels in Type 1 Diabetes
- Download full text (pdf) of Endogenous Levels of Gamma Amino-Butyric Acid Are Correlated to Glutamic-Acid Decarboxylase Antibody Levels in Type 1 Diabetes
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Pregnancy induces pancreatic insulin secretion in women with long-standing type 1 diabetes
Part of BMJ Open Diabetes Research & Care, 2022
- DOI for Pregnancy induces pancreatic insulin secretion in women with long-standing type 1 diabetes
- Download full text (pdf) of Pregnancy induces pancreatic insulin secretion in women with long-standing type 1 diabetes
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Irisin-A Pancreatic Islet Hormone
Part of Biomedicines, 2022
- DOI for Irisin-A Pancreatic Islet Hormone
- Download full text (pdf) of Irisin-A Pancreatic Islet Hormone
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Part of Journal of Sleep Research, 2022
- DOI for Acute sleep loss alters circulating fibroblast growth factor 21 levels in humans: A randomised crossover trial.
- Download full text (pdf) of Acute sleep loss alters circulating fibroblast growth factor 21 levels in humans: A randomised crossover trial.
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Part of BMJ Open Diabetes Research & Care, 2022
- DOI for Higher risk of severe hypoglycemia in children and adolescents with a rapid loss of C-peptide during the first 6 years after type 1 diabetes diagnosis
- Download full text (pdf) of Higher risk of severe hypoglycemia in children and adolescents with a rapid loss of C-peptide during the first 6 years after type 1 diabetes diagnosis
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Part of Peptides, 2021
- DOI for CART decreases islet blood flow, but has no effect on total pancreatic blood flow and glucose tolerance in anesthetized rats
- Download full text (pdf) of CART decreases islet blood flow, but has no effect on total pancreatic blood flow and glucose tolerance in anesthetized rats
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Part of International Journal of Molecular Sciences, 2021
- DOI for Interleukin-35 Prevents Development of Autoimmune Diabetes Possibly by Maintaining the Phenotype of Regulatory B Cells
- Download full text (pdf) of Interleukin-35 Prevents Development of Autoimmune Diabetes Possibly by Maintaining the Phenotype of Regulatory B Cells
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GABA induces a hormonal counter-regulatory response in subjects with long-standing type 1 diabetes
Part of BMJ Open Diabetes Research & Care, 2021
- DOI for GABA induces a hormonal counter-regulatory response in subjects with long-standing type 1 diabetes
- Download full text (pdf) of GABA induces a hormonal counter-regulatory response in subjects with long-standing type 1 diabetes
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Longitudinal Assessment of 11C-5-Hydroxytryptophan Uptake in Pancreas After Debut of Type 1 Diabetes
Part of Diabetes, p. 966-975, 2021
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Part of Obesity, p. 535-542, 2021
- DOI for Changes in Circulating Cytokines and Adipokines After RYGB in Patients with and without Type 2 Diabetes
- Download full text (pdf) of Changes in Circulating Cytokines and Adipokines After RYGB in Patients with and without Type 2 Diabetes
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Part of Läkartidningen, 2020
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Part of Frontiers in Immunology, 2020
- DOI for Mass Cytometry Studies of Patients With Autoimmune Endocrine Diseases Reveal Distinct Disease-Specific Alterations in Immune Cell Subsets
- Download full text (pdf) of Mass Cytometry Studies of Patients With Autoimmune Endocrine Diseases Reveal Distinct Disease-Specific Alterations in Immune Cell Subsets
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Part of Frontiers in Immunology, 2020
- DOI for Increased Plasma Levels of the Co-stimulatory Proteins CDCP1 and SLAMF1 in Patients With Autoimmune Endocrine Diseases
- Download full text (pdf) of Increased Plasma Levels of the Co-stimulatory Proteins CDCP1 and SLAMF1 in Patients With Autoimmune Endocrine Diseases
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Part of Endocrine, p. 344-353, 2020
- DOI for Rapid changes in neuroendocrine regulation may contribute to reversal of type 2 diabetes after gastric bypass surgery
- Download full text (pdf) of Rapid changes in neuroendocrine regulation may contribute to reversal of type 2 diabetes after gastric bypass surgery
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Part of BMJ Open Diabetes Research & Care, 2020
- DOI for Better HbA1c during the first years after diagnosis of type 1 diabetes is associated with residual C peptide 10 years later
- Download full text (pdf) of Better HbA1c during the first years after diagnosis of type 1 diabetes is associated with residual C peptide 10 years later
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Part of Physiological Reports, 2020
- DOI for Highly blood perfused, highly metabolically active pancreatic islets may be more susceptible for immune attack
- Download full text (pdf) of Highly blood perfused, highly metabolically active pancreatic islets may be more susceptible for immune attack
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Part of Upsala Journal of Medical Sciences, p. 228-237, 2019
- DOI for Characterization of neural crest-derived stem cells isolated from human bone marrow for improvement of transplanted islet function.
- Download full text (pdf) of Characterization of neural crest-derived stem cells isolated from human bone marrow for improvement of transplanted islet function.
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Unsurpassed Intrahepatic Islet Engraftment: the Quest for New Sites for Beta Cell Replacement
Part of Cell Medicine, 2019
- DOI for Unsurpassed Intrahepatic Islet Engraftment: the Quest for New Sites for Beta Cell Replacement
- Download full text (pdf) of Unsurpassed Intrahepatic Islet Engraftment: the Quest for New Sites for Beta Cell Replacement
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Metabolically Active Brown Adipose Tissue Is Found in Adult Subjects with Type 1 Diabetes.
Part of International Journal of Molecular Sciences, 2019
- DOI for Metabolically Active Brown Adipose Tissue Is Found in Adult Subjects with Type 1 Diabetes.
- Download full text (pdf) of Metabolically Active Brown Adipose Tissue Is Found in Adult Subjects with Type 1 Diabetes.
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Pancreatic perfusion and its response to glucose as measured by simultaneous PET/MRI
Part of Acta Diabetologica, p. 1113-1120, 2019
- DOI for Pancreatic perfusion and its response to glucose as measured by simultaneous PET/MRI
- Download full text (pdf) of Pancreatic perfusion and its response to glucose as measured by simultaneous PET/MRI
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Part of Clinical and Experimental Immunology, p. 64-73, 2019
- DOI for Cellular immunological changes in patients with LADA are a mixture of those seen in patients with type 1 and type 2 diabetes
- Download full text (pdf) of Cellular immunological changes in patients with LADA are a mixture of those seen in patients with type 1 and type 2 diabetes
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Part of PLOS ONE, 2018
- DOI for Expression of calcium release-activated and voltage-gated calcium channels genes in peripheral blood mononuclear cells is altered in pregnancy and in type 1 diabetes
- Download full text (pdf) of Expression of calcium release-activated and voltage-gated calcium channels genes in peripheral blood mononuclear cells is altered in pregnancy and in type 1 diabetes
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Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells
Part of EBioMedicine, 2018
- DOI for Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells
- Download full text (pdf) of Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells
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Part of EBioMedicine, p. 283-294, 2018
- DOI for GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4+ T Cells and Is Immunosuppressive in Type 1 Diabetes
- Download full text (pdf) of GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4+ T Cells and Is Immunosuppressive in Type 1 Diabetes
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Part of American Journal of Transplantation, p. 1735-1744, 2018
- DOI for Transplantation of macroencapsulated human islets within the bioartificial pancreas βAir to patients with type 1 diabetes mellitus
- Download full text (pdf) of Transplantation of macroencapsulated human islets within the bioartificial pancreas βAir to patients with type 1 diabetes mellitus
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Part of Journal of Diabetes Research, 2017
- DOI for The Increased Circulating Plasma Levels of Vascular Endothelial Growth Factor in Patients with Type 1 Diabetes Do Not Correlate to Metabolic Control
- Download full text (pdf) of The Increased Circulating Plasma Levels of Vascular Endothelial Growth Factor in Patients with Type 1 Diabetes Do Not Correlate to Metabolic Control
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Role of regulatory B cells in clinical and experimental type 1 diabetes
Part of Scandinavian Journal of Immunology, p. 349-349, 2017
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[(11)C]5-Hydroxy-Tryptophan PET for Assessment of Islet Mass During Progression of Type 2 Diabetes
Part of Diabetes, p. 1286-1292, 2017
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Increased Interleukin-35 Levels in Patients With Type 1 Diabetes With Remaining C-Peptide
Part of Diabetes Care, p. 1090-1095, 2017
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Part of American Journal of Transplantation, p. 3246-3254, 2016
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Part of Diabetologia, p. 1968-1972, 2016
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Part of Transplantation, 2016
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Quantification of Beta-Cell Mass in Intramuscular Islet Grafts using Radiolabeled Exendin-4
Part of Transplantation Direct, 2016
- DOI for Quantification of Beta-Cell Mass in Intramuscular Islet Grafts using Radiolabeled Exendin-4
- Download full text (pdf) of Quantification of Beta-Cell Mass in Intramuscular Islet Grafts using Radiolabeled Exendin-4
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Part of Scientific Reports, 2015
- DOI for Interleukin-35 administration counteracts established murine type 1 diabetes - possible involvement of regulatory T cells
- Download full text (pdf) of Interleukin-35 administration counteracts established murine type 1 diabetes - possible involvement of regulatory T cells
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Part of Transplantation, p. 2077-2082, 2015
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Increased levels of irisin in people with long-standing Type1 diabetes
Part of Diabetic Medicine, p. 1172-1176, 2015
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The Cannabinoid Receptor-1 Is an Imaging Biomarker of Brown Adipose Tissue
Part of Journal of Nuclear Medicine, p. 1937-1941, 2015
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Part of Journal of labelled compounds & radiopharmaceuticals, 2015
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Dosimetry of [Ga-68]Ga-DO3A-VS-Cys(40)-Exendin-4 in rodents, pigs, non-human primates and human
Part of Journal of labelled compounds & radiopharmaceuticals, 2015
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Part of Diabetes, p. 3428-3437, 2014
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Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes
Part of Diabetologia, p. 50-53, 2014
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Increased Circulating Betatrophin Concentrations in Patients with Type 2 Diabetes
Part of International Journal of Endocrinology, p. 323407, 2014
- DOI for Increased Circulating Betatrophin Concentrations in Patients with Type 2 Diabetes
- Download full text (pdf) of Increased Circulating Betatrophin Concentrations in Patients with Type 2 Diabetes
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Part of Upsala Journal of Medical Sciences, p. 130-133, 2013
Articles, review/survey
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Part of Frontiers in Physiology, 2019
- DOI for Heterogeneity of Metabolic Defects in Type 2 Diabetes and Its Relation to Reactive Oxygen Species and Alterations in Beta-Cell Mass
- Download full text (pdf) of Heterogeneity of Metabolic Defects in Type 2 Diabetes and Its Relation to Reactive Oxygen Species and Alterations in Beta-Cell Mass
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Towards the clinical translation of stem cell therapy for type 1 diabetes
Part of European Journal of Endocrinology, 2017
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Pancreatic islet blood flow and its measurement
Part of Upsala Journal of Medical Sciences, p. 81-95, 2016
- DOI for Pancreatic islet blood flow and its measurement
- Download full text (pdf) of Pancreatic islet blood flow and its measurement
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Betatrophin in Diabetes Mellitus: the Epidemiological Evidence in Humans
Part of Current Diabetes Reports, 2015
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Striated Muscle as Implantation Site for Transplanted Pancreatic Islets
Part of Journal of Transplantation, p. 352043, 2011
Comprehensive doctoral thesis
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2016
Conference papers
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Increased Circulating Betatrophin Concentrations in Patients with Type 2 Diabetes
Part of Typ1 ?Typ x Språk: - Engelska Svenska Norska Arabiska Bokmål Bulgariska Danska Engelska Esperanto Estniska Finska Franska Färöiska Grönländska (Kalaallit oqaasi) Hebreiska Hindi Indonesiska Iriska Isländska Italienska Japanska Katalanska Kinesiska Koreanska Kroatiska Kurdiska Latin Lettiska Litauiska Madurese Makedonska Mongoliskt språk Nederländska Norska Nygrekiska (1453-) Nynorsk Odefinierat språk Persiska Polska Portugisiska Rumänska Ryska Samiskt språk Sanskrit Serbiska Slovakiska Slovenska Spanska Svenska Tjeckiska Turkiska Tyska Ukrainska Ungerska Urdu Vietnamesiska, 2014