Klinisk epidemiologi

Vi skapar värde för patienter och populationer med big data.
Beskrivning av vår forskning

Professor Johan Sundström. Foto: Mikael Wallerstedt.
Vår forskargrupp leder ett nationellt strategiskt forskningsprogram inom epidemiologi. Vi använder många av Sveriges kohorter i vår forskning, har samlat in några av dem själva, och vi leder ett nationellt initiativ för att öka värdet av alla svenska kohorter. Vi leder också randomiserade kliniska prövningar, huvudsakligen inom kardiometabola sjukdomar och akutsjukvård, och gör systematiska litteraturöversikter och meta-analyser.
Vår metodutveckling är inriktad på att använda stora databaser, big data, för att förbättra sjukvårdens riskbedömning, behandlingsbeslut och utvärdering av behandlingseffekter, risker och kostnader. Förutom traditionella datakällor, som kliniska prövningar och kohorter med eller utan omics-data, så använder vi nya källor som elektroniska journaler och patientgenererade data. Vi använder kausal inferens-metoder som Mendelsk randomisering, kausala diagram och propensity score-baserade metoder. Vi använder också maskininlärningsmetoder och utvecklar nya digitala metoder för klinisk forskning.
Gruppmedlemmar
Forskningsprojekt
- AI-baserad EKG-diagnostik av hjärtinfarkter
- Förbättra akutmottagningens säkerhet, effektivitet och kostnadseffektivitet genom artificiell intelligens (EmergAI)
- Hembaserad screening för hjärtsvikt (U-SCREEN-HF)
- Hitta hotande hjärtinfarkter (MIMI)
- Minforskning.se
- Skräddarsydd blodtrycksbehandling (PHYSIC)
- Storskalig analys av befolkningsstudier (Cohorts.se)
- U-SCREEN - Uppsala självscreening av hjärtkärlhälsa
Publikationer
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Standardized Mortality Ratio and Long-Term Stroke Incidence After PFO Closure: A Register Study
Ingår i JACC: Advances, 2026
- DOI för Standardized Mortality Ratio and Long-Term Stroke Incidence After PFO Closure: A Register Study
- Ladda ner fulltext (pdf) av Standardized Mortality Ratio and Long-Term Stroke Incidence After PFO Closure: A Register Study
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Ingår i Scientific Reports, 2026
- DOI för A latent class analysis of cardiometabolic risk factors and the predicted prevalence of subclinical atherosclerosis in middle-aged Swedish adults
- Ladda ner fulltext (pdf) av A latent class analysis of cardiometabolic risk factors and the predicted prevalence of subclinical atherosclerosis in middle-aged Swedish adults
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Ingår i Nature Medicine, s. 1351-1361, 2026
- DOI för Antibiotic use and gut microbiome composition links from individual-level prescription data of 14,979 individuals
- Ladda ner fulltext (pdf) av Antibiotic use and gut microbiome composition links from individual-level prescription data of 14,979 individuals
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Coronary Computed Tomography Angiography in Prediction of First Coronary Events
Ingår i Journal of the American Medical Association (JAMA), s. 245-254, 2026
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Frail Older Patients' Experiences During Boarding in the Emergency Department: A Qualitative Study
Ingår i Journal of Advanced Nursing, s. 5244-5255, 2026
- DOI för Frail Older Patients' Experiences During Boarding in the Emergency Department: A Qualitative Study
- Ladda ner fulltext (pdf) av Frail Older Patients' Experiences During Boarding in the Emergency Department: A Qualitative Study
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Ingår i Pharmacoepidemiology and Drug Safety, 2026
- DOI för Methodological Challenges of Emulating a Target Trial to Assess Effectiveness of Timing of PCSK9 Inhibitor Treatment Initiation Post Myocardial Infarction
- Ladda ner fulltext (pdf) av Methodological Challenges of Emulating a Target Trial to Assess Effectiveness of Timing of PCSK9 Inhibitor Treatment Initiation Post Myocardial Infarction
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GWAS and Replication Analysis of Apparent Treatment-Resistant Hypertension
Ingår i Hypertension, 2026
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Ingår i BMC Medicine, 2026
- DOI för Adolescent intelligence and imaging-detected atherosclerosis in middle age: a population study of Swedish men
- Ladda ner fulltext (pdf) av Adolescent intelligence and imaging-detected atherosclerosis in middle age: a population study of Swedish men
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Ingår i Diabetes, obesity and metabolism, s. 1327-1338, 2026
- DOI för SGLT2 inhibitor or metformin as standard treatment in early-stage type 2 diabetes? Baseline data in SMARTEST, a novel, decentralised, register-based randomised trial on prevention of diabetic complications
- Ladda ner fulltext (pdf) av SGLT2 inhibitor or metformin as standard treatment in early-stage type 2 diabetes? Baseline data in SMARTEST, a novel, decentralised, register-based randomised trial on prevention of diabetic complications
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Ingår i European Stroke Journal, 2026
- DOI för Early versus delayed DOAC after ischaemic stroke in atrial fibrillation: 1-year outcomes in the TIMING study and in concurrent practice
- Ladda ner fulltext (pdf) av Early versus delayed DOAC after ischaemic stroke in atrial fibrillation: 1-year outcomes in the TIMING study and in concurrent practice
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Ingår i Scientific Reports, 2026
- DOI för Plasma neuropilin-1 is associated with a favorable lipid profile and insulin sensitivity in a population-based sample of 50-year-old individuals
- Ladda ner fulltext (pdf) av Plasma neuropilin-1 is associated with a favorable lipid profile and insulin sensitivity in a population-based sample of 50-year-old individuals
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Ingår i Therapeutic Advances in Gastroenterology, 2026
- DOI för Association of inflammatory bowel disease with cardiovascular disease, and the mediating role of inflammation: a matched-cohort study
- Ladda ner fulltext (pdf) av Association of inflammatory bowel disease with cardiovascular disease, and the mediating role of inflammation: a matched-cohort study
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Ingår i Journal of Hypertension, s. 346-353, 2026
- DOI för Systolic inter-arm blood pressure difference and subclinical atherosclerosis: a population-based cohort study of 29 921 individuals
- Ladda ner fulltext (pdf) av Systolic inter-arm blood pressure difference and subclinical atherosclerosis: a population-based cohort study of 29 921 individuals
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A deep learning ECG model for identification and localization of occlusion myocardial infarction
Ingår i Nature Communications, 2026
- DOI för A deep learning ECG model for identification and localization of occlusion myocardial infarction
- Ladda ner fulltext (pdf) av A deep learning ECG model for identification and localization of occlusion myocardial infarction
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Ingår i Hypertension, s. 167-176, 2026
- DOI för Consistency of Blood Pressure Response to Potassium-Enriched Salt in the China Salt Substitute Study.
- Ladda ner fulltext (pdf) av Consistency of Blood Pressure Response to Potassium-Enriched Salt in the China Salt Substitute Study.
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Ingår i Journal of Investigative Dermatology, 2026
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Ingår i eClinicalMedicine, 2026
- DOI för Persistence to antihypertensive drug classes in uncomplicated hypertension: a nationwide Swedish cohort study
- Ladda ner fulltext (pdf) av Persistence to antihypertensive drug classes in uncomplicated hypertension: a nationwide Swedish cohort study
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Ingår i Nature Medicine, s. 1454-1478, 2026
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Plasma protein profiles in different heart failure phenotypes
Ingår i ESC Heart Failure, 2026
- DOI för Plasma protein profiles in different heart failure phenotypes
- Ladda ner fulltext (pdf) av Plasma protein profiles in different heart failure phenotypes
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Cardiomyopathies: Nationwide Trends in Prevalence, Incidence, and Mortality (2004-2023)
Ingår i Journal of the American College of Cardiology, s. 1087-1090, 2026
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Ingår i Acta Obstetricia et Gynecologica Scandinavica, s. 466-478, 2026
- DOI för Differences in prediction of adverse perinatal outcome in term pregnancies by choice of fetal growth reference: A validation study
- Ladda ner fulltext (pdf) av Differences in prediction of adverse perinatal outcome in term pregnancies by choice of fetal growth reference: A validation study
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Impact of kidney function on the metabolome in the general population
Ingår i PLOS ONE, 2026
- DOI för Impact of kidney function on the metabolome in the general population
- Ladda ner fulltext (pdf) av Impact of kidney function on the metabolome in the general population
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Ingår i European journal of emergency medicine, s. 138-138, 2026
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Ingår i European journal of emergency medicine, s. 18-23, 2026
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Ingår i BMC Nursing, 2026
- DOI för Opening Pandora's box in the emergency room: a secondary analysis of existential needs from observational, registered nurse, and patient perspectives
- Ladda ner fulltext (pdf) av Opening Pandora's box in the emergency room: a secondary analysis of existential needs from observational, registered nurse, and patient perspectives
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Ingår i Cell Reports, 2026
- DOI för RAB3GAP2 is a regulator of skeletal muscle endothelial cell proliferation and associated with capillary-to-fiber ratio
- Ladda ner fulltext (pdf) av RAB3GAP2 is a regulator of skeletal muscle endothelial cell proliferation and associated with capillary-to-fiber ratio
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Obesity rise plateaus in developed nations and accelerates in developing nations
Ingår i Nature, s. 510-518, 2026
- DOI för Obesity rise plateaus in developed nations and accelerates in developing nations
- Ladda ner fulltext (pdf) av Obesity rise plateaus in developed nations and accelerates in developing nations
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Ingår i Environment International, 2026
- DOI för An exploratory study of environmental and nutritional determinants of early-stage clonal hematopoiesis in the elderly
- Ladda ner fulltext (pdf) av An exploratory study of environmental and nutritional determinants of early-stage clonal hematopoiesis in the elderly
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Ingår i BMJ Open, 2025
- DOI för Effect of the FoodSwitch application on type 2 diabetes in Sweden: a study protocol for the randomised controlled DIgitAl diabeTES Treatment - the Healthy Eating, heaLthy Patients trial (DIATEST-HELP)
- Ladda ner fulltext (pdf) av Effect of the FoodSwitch application on type 2 diabetes in Sweden: a study protocol for the randomised controlled DIgitAl diabeTES Treatment - the Healthy Eating, heaLthy Patients trial (DIATEST-HELP)
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Impact of genetic variants linked to liver fat and liver volume on MRI-mapped body composition
Ingår i JHEP Reports, 2025
- DOI för Impact of genetic variants linked to liver fat and liver volume on MRI-mapped body composition
- Ladda ner fulltext (pdf) av Impact of genetic variants linked to liver fat and liver volume on MRI-mapped body composition
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Ingår i Läkartidningen, 2025
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Ingår i International Journal for Equity in Health, 2025
- DOI för Socio-geographical disparities in cardiometabolic multimorbidity in Sweden: an Intersectional Multilevel Analysis of Individual Heterogeneity and Discriminatory Accuracy (I-MAIHDA)
- Ladda ner fulltext (pdf) av Socio-geographical disparities in cardiometabolic multimorbidity in Sweden: an Intersectional Multilevel Analysis of Individual Heterogeneity and Discriminatory Accuracy (I-MAIHDA)
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Ingår i Metabolism, 2025
- DOI för Plasma metabolite profiles of meat intake and their association with cardiovascular disease risk: A population-based study in Swedish cohorts
- Ladda ner fulltext (pdf) av Plasma metabolite profiles of meat intake and their association with cardiovascular disease risk: A population-based study in Swedish cohorts
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Ingår i Metabolism, 2025
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Ingår i Atherosclerosis, 2025
- DOI för Different plasma biomarker patterns associated with coronary atherosclerosis in low- versus high-risk individuals: - an observational cross-sectional study
- Ladda ner fulltext (pdf) av Different plasma biomarker patterns associated with coronary atherosclerosis in low- versus high-risk individuals: - an observational cross-sectional study
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Ingår i Neuroscience and Biobehavioral Reviews, 2025
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Ingår i Cardiovascular Research, s. 2360-2373, 2025
- DOI för A multi-omics approach uncovers causality of IL6R on endotypes of subclinical carotid atherosclerosis and the possible role of the IL6R/OSMR pathway
- Ladda ner fulltext (pdf) av A multi-omics approach uncovers causality of IL6R on endotypes of subclinical carotid atherosclerosis and the possible role of the IL6R/OSMR pathway
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Ingår i The Lancet, s. 43-51, 2025
- DOI för Collaboration on the optimal timing of anticoagulation after ischaemic stroke and atrial fibrillation: a systematic review and prospective individual participant data meta-analysis of randomised controlled trials (CATALYST)
- Ladda ner fulltext (pdf) av Collaboration on the optimal timing of anticoagulation after ischaemic stroke and atrial fibrillation: a systematic review and prospective individual participant data meta-analysis of randomised controlled trials (CATALYST)
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Ingår i Heart, s. 300-305, 2025
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Associations between physical activity and CVD-related metabolomic and proteomic biomarkers
Ingår i PLOS ONE, 2025
- DOI för Associations between physical activity and CVD-related metabolomic and proteomic biomarkers
- Ladda ner fulltext (pdf) av Associations between physical activity and CVD-related metabolomic and proteomic biomarkers
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Implementing electronic informed consent in rare disease genomics
Ingår i Scientific Reports, 2025
- DOI för Implementing electronic informed consent in rare disease genomics
- Ladda ner fulltext (pdf) av Implementing electronic informed consent in rare disease genomics
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Ingår i Clinical Kidney Journal, 2025
- DOI för Causal effects of obesity on estimated glomerular filtration rate: a Mendelian randomization and image data analysis study
- Ladda ner fulltext (pdf) av Causal effects of obesity on estimated glomerular filtration rate: a Mendelian randomization and image data analysis study
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Ingår i Cardiovascular Research, s. 1649-1652, 2025
- DOI för Plasma proteomic and metabolomic profiling of coronary and carotid atherosclerosis in the SCAPIS study: differences and similarities
- Ladda ner fulltext (pdf) av Plasma proteomic and metabolomic profiling of coronary and carotid atherosclerosis in the SCAPIS study: differences and similarities
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Ingår i European Heart Journal - Quality of Care and Clinical Outcomes, s. 415-423, 2025
- DOI för Diverticular disease and risk of incident major adverse cardiovascular events: a nationwide matched cohort study
- Ladda ner fulltext (pdf) av Diverticular disease and risk of incident major adverse cardiovascular events: a nationwide matched cohort study
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Ingår i Nature Communications, 2025
- DOI för Effects of an anti-lipogenic low-carbohydrate high polyunsaturated fat diet or a healthy Nordic diet versus usual care on liver fat and cardiometabolic disorders in type 2 diabetes or prediabetes: a randomized controlled trial (NAFLDiet)
- Ladda ner fulltext (pdf) av Effects of an anti-lipogenic low-carbohydrate high polyunsaturated fat diet or a healthy Nordic diet versus usual care on liver fat and cardiometabolic disorders in type 2 diabetes or prediabetes: a randomized controlled trial (NAFLDiet)
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A genome-wide association study of imaging-defined atherosclerosis
Ingår i Nature Communications, 2025
- DOI för A genome-wide association study of imaging-defined atherosclerosis
- Ladda ner fulltext (pdf) av A genome-wide association study of imaging-defined atherosclerosis
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Ingår i The Lancet, s. 1873-1922, 2025
- DOI för Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
- Ladda ner fulltext (pdf) av Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
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Ingår i Nature Genetics, s. 815-828, 2025
- DOI för Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes
- Ladda ner fulltext (pdf) av Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes
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Ingår i Scandinavian Cardiovascular Journal, 2025
- DOI för Prevalence of atrial fibrillation among Swedish adults participating in the general population study EpiHealth
- Ladda ner fulltext (pdf) av Prevalence of atrial fibrillation among Swedish adults participating in the general population study EpiHealth
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Studentlitteratur AB, 2025
Anders Wiklöf-institutet för hjärtforskning
Anders Wiklöf-institutet för hjärtforskning är en fokuserad forskningssatsning med målet att bättre kunna förutse och förhindra hjärt-kärlsjukdomar. Institutet har kunnat starta tack vare en donation av den åländske affärsmannen Anders Wiklöf. Vid institutet möter experter inom hjärt-kärlsjukdomar experter inom datavetenskaper, artificiell intelligens (AI), statistik, innovation, och förvaltning och tillgängliggörande av medicinska datamängder.
Läs mer om Anders Wiklöf-institutet för hjärtforskning (AWI)
Anders Wiklöf-institutet för hjärtforskning på besök hos Ålands lyceum