Klinisk epidemiologi
Vi skapar värde för patienter och populationer med big data.
Beskrivning av vår forskning
Vår forskargrupp leder ett nationellt strategiskt forskningsprogram inom epidemiologi. Vi använder många av Sveriges kohorter i vår forskning, har samlat in några av dem själva, och vi leder ett nationellt initiativ för att öka värdet av alla svenska kohorter. Vi leder också randomiserade kliniska prövningar, huvudsakligen inom kardiometabola sjukdomar och akutsjukvård, och gör systematiska litteraturöversikter och meta-analyser.
Vår metodutveckling är inriktad på att använda stora databaser, big data, för att förbättra sjukvårdens riskbedömning, behandlingsbeslut och utvärdering av behandlingseffekter, risker och kostnader. Förutom traditionella datakällor, som kliniska prövningar och kohorter med eller utan omics-data, så använder vi nya källor som elektroniska journaler och patientgenererade data. Vi använder kausal inferens-metoder som Mendelsk randomisering, kausala diagram och propensity score-baserade metoder. Vi använder också maskininlärningsmetoder och utvecklar nya digitala metoder för klinisk forskning.
Gruppmedlemmar
Publikationer
Ingår i Circulation Heart Failure, 2024
Ingår i EBioMedicine, 2024
Dietary patterns, untargeted metabolite profiles and their association with colorectal cancer risk
Ingår i Scientific Reports, 2024
Usefulness of Heart Failure Categories Based on Left Ventricular Ejection Fraction
Ingår i Journal of the American Heart Association, 2024
Ingår i BMC Health Services Research, 2024
- DOI för Factors predictive of hospital admission for children via emergency departments in Australia and Sweden: an observational cross-sectional study
- Ladda ner fulltext (pdf) av Factors predictive of hospital admission for children via emergency departments in Australia and Sweden: an observational cross-sectional study
Ingår i Respiratory Research, 2024
- DOI för Exertional breathlessness related to medical conditions in middle-aged people: the population-based SCAPIS study of more than 25,000 men and women
- Ladda ner fulltext (pdf) av Exertional breathlessness related to medical conditions in middle-aged people: the population-based SCAPIS study of more than 25,000 men and women
Ingår i Eur J Epidemiol, 2024
Ingår i Journal of Affective Disorders, s. 96-103, 2024
- DOI för Association between neighborhood socioeconomic status and healthcare utilization among individuals with a first diagnosis of major depressive disorder in primary care in the Stockholm region
- Ladda ner fulltext (pdf) av Association between neighborhood socioeconomic status and healthcare utilization among individuals with a first diagnosis of major depressive disorder in primary care in the Stockholm region
Analysis of plasma metabolomes from 11 309 subjects in five population-based cohorts.
Ingår i Scientific Reports, s. 8933, 2024
Markers of imminent myocardial infarction
Ingår i Nature Cardiovascular Research, 2024
More Evidence That HF With Normal EF Is Distinct From HF Below Normal EF
Ingår i Journal of the American College of Cardiology, s. 1740-1742, 2024
Ingår i Mayo Clinic proceedings, s. 69-80, 2024
Cardiopulmonary exercise testing and body composition.
Ingår i ERJ open research, 2024
Ingår i Stroke, s. 50-58, 2024
Ingår i BMC Oral Health, 2024
An association between heart rate variability and incident heart failure in an elderly cohort
Ingår i Clinical Cardiology, 2024
Ingår i The Lancet, s. 1027-1050, 2024
- DOI för Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
- Ladda ner fulltext (pdf) av Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
Ingår i Environment International, 2024
Ingår i BMC Pulmonary Medicine, 2024
Ingår i Journal of Mass Spectrometry, 2024
- DOI för Assessing the performance of a targeted absolute quantification isotope dilution liquid chromatograhy tandem mass spectrometry assay versus a commercial nontargeted relative quantification assay for detection of three major perfluoroalkyls in human blood
- Ladda ner fulltext (pdf) av Assessing the performance of a targeted absolute quantification isotope dilution liquid chromatograhy tandem mass spectrometry assay versus a commercial nontargeted relative quantification assay for detection of three major perfluoroalkyls in human blood
Are there lost opportunities in chronic kidney disease?: A region-wide cohort study
Ingår i BMJ Open, 2024
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
Ingår i Nature, s. 347-357, 2024
Ingår i Journal of Clinical Medicine, 2024
- DOI för The Human Phospholipase B-II Precursor (HPLBII-P) in Urine as a Novel Biomarker of Increased Glomerular Production or Permeability in Diabetes Mellitus?
- Ladda ner fulltext (pdf) av The Human Phospholipase B-II Precursor (HPLBII-P) in Urine as a Novel Biomarker of Increased Glomerular Production or Permeability in Diabetes Mellitus?
Ingår i Scientific Reports, 2024
- DOI för A combined observational and Mendelian randomization investigation reveals NMR-measured analytes to be risk factors of major cardiovascular diseases
- Ladda ner fulltext (pdf) av A combined observational and Mendelian randomization investigation reveals NMR-measured analytes to be risk factors of major cardiovascular diseases
Ingår i Chest, s. 503-516, 2023
- DOI för OSA Is Associated With the Human Gut Microbiota Composition and Functional Potential in the Population-Based Swedish CardioPulmonary bioImage Study
- Ladda ner fulltext (pdf) av OSA Is Associated With the Human Gut Microbiota Composition and Functional Potential in the Population-Based Swedish CardioPulmonary bioImage Study
Ingår i European Journal of Preventive Cardiology, s. 1007-1014, 2023
Ingår i Atherosclerosis, s. 46-54, 2023
Loci for insulin processing and secretion provide insight into type 2 diabetes risk.
Ingår i American Journal of Human Genetics, s. 284-299, 2023
Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases
Ingår i Clinical Proteomics, 2023
A machine learning based approach to identify carotid subclinical atherosclerosis endotypes
Ingår i Cardiovascular Research, s. 2594-2606, 2023
Ingår i Psychiatry Research, 2023
- DOI för The association between exposure to clozapine, olanzapine, and quetiapine and the outcomes perimyocarditis and heart failure: A population-based cohort study
- Ladda ner fulltext (pdf) av The association between exposure to clozapine, olanzapine, and quetiapine and the outcomes perimyocarditis and heart failure: A population-based cohort study
Ingår i Journal of Exposure Science and Environmental Epidemiology, s. 748-756, 2023
Ingår i Environment International, 2023
- DOI för Plasma levels of per- and polyfluoroalkyl substances (PFAS) and cardiovascular disease - Results from two independent population-based cohorts and a meta-analysis
- Ladda ner fulltext (pdf) av Plasma levels of per- and polyfluoroalkyl substances (PFAS) and cardiovascular disease - Results from two independent population-based cohorts and a meta-analysis
Ingår i BMJ Open, 2023
- DOI för Accelerometer derived physical activity and subclinical coronary and carotid atherosclerosis: cross-sectional analyses in 22 703 middle-aged men and women in the SCAPIS study
- Ladda ner fulltext (pdf) av Accelerometer derived physical activity and subclinical coronary and carotid atherosclerosis: cross-sectional analyses in 22 703 middle-aged men and women in the SCAPIS study
Ingår i Journal of Advanced Nursing, s. 3115-3126, 2023
- DOI för Fundamental nursing actions for frail older people in the emergency department: A national cross-sectional survey and a qualitative analysis of practice guidelines
- Ladda ner fulltext (pdf) av Fundamental nursing actions for frail older people in the emergency department: A national cross-sectional survey and a qualitative analysis of practice guidelines
Ingår i BMJ Open, 2023
- DOI för Multicentre, national, investigator-initiated, randomised, parallel-group, register-based superiority trial to compare extended ECG monitoring versus standard ECG monitoring in elderly patients with ischaemic stroke or transient ischaemic attack and the effect on stroke, death and intracerebral bleeding: the AF SPICE protocol
- Ladda ner fulltext (pdf) av Multicentre, national, investigator-initiated, randomised, parallel-group, register-based superiority trial to compare extended ECG monitoring versus standard ECG monitoring in elderly patients with ischaemic stroke or transient ischaemic attack and the effect on stroke, death and intracerebral bleeding: the AF SPICE protocol
Ingår i Journal of the American College of Cardiology, s. 1343-1359, 2023
Ingår i Clinical Gastroenterology and Hepatology, 2023
Ingår i Clinical Nutrition, s. 1922-1931, 2023
Ingår i European Journal of Nutrition, s. 145-153, 2023
- DOI för Substitution analyses of foods with varying fat quality and the associations with all-cause mortality and impact of the FADS-1 genotype in elderly men
- Ladda ner fulltext (pdf) av Substitution analyses of foods with varying fat quality and the associations with all-cause mortality and impact of the FADS-1 genotype in elderly men
Cardiovascular Outcomes in Patients With Biopsy-proven Alcohol-related Liver Disease
Ingår i Clinical Gastroenterology and Hepatology, s. 1841-1853000000000000, 2023
Ingår i JACC Cardiovascular Imaging, s. 1193-1204, 2023
Associations of perfluoroalkyl substances (PFAS) with lipid and lipoprotein profiles
Ingår i Journal of Exposure Science and Environmental Epidemiology, s. 757-765, 2023
Life's Essential 8 and carotid artery plaques: the Swedish cardiopulmonary bioimage study
Ingår i Frontiers in Cardiovascular Medicine, 2023
Ingår i Scandinavian Journal of Public Health, s. 527-530, 2023
- DOI för Low prevalence of ideal cardiovascular health in the general Swedish population: Results from the Swedish CArdioPulmonary bioImage Study (SCAPIS)
- Ladda ner fulltext (pdf) av Low prevalence of ideal cardiovascular health in the general Swedish population: Results from the Swedish CArdioPulmonary bioImage Study (SCAPIS)
Ingår i BMC Geriatrics, 2023
Ingår i The Lancet Diabetes and Endocrinology, s. 731-742, 2023
- DOI för Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries: 23 million person-years of observation
- Ladda ner fulltext (pdf) av Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries: 23 million person-years of observation
Ingår i Frontiers in Public Health, 2023
Ingår i The Lancet Global Health, 2023
- DOI för Global burden of peripheral artery disease and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
- Ladda ner fulltext (pdf) av Global burden of peripheral artery disease and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
Ingår i Cogent Social Sciences, 2023
- DOI för Medical students experience mistreatment, with a focus on gender discrimination. Cross-sectional study at one Swedish medical school
- Ladda ner fulltext (pdf) av Medical students experience mistreatment, with a focus on gender discrimination. Cross-sectional study at one Swedish medical school