Klinisk epidemiologi

Vi skapar värde för patienter och populationer med big data.
Beskrivning av vår forskning

Professor Johan Sundström. Foto: Mikael Wallerstedt.
Vår forskargrupp leder ett nationellt strategiskt forskningsprogram inom epidemiologi. Vi använder många av Sveriges kohorter i vår forskning, har samlat in några av dem själva, och vi leder ett nationellt initiativ för att öka värdet av alla svenska kohorter. Vi leder också randomiserade kliniska prövningar, huvudsakligen inom kardiometabola sjukdomar och akutsjukvård, och gör systematiska litteraturöversikter och meta-analyser.
Vår metodutveckling är inriktad på att använda stora databaser, big data, för att förbättra sjukvårdens riskbedömning, behandlingsbeslut och utvärdering av behandlingseffekter, risker och kostnader. Förutom traditionella datakällor, som kliniska prövningar och kohorter med eller utan omics-data, så använder vi nya källor som elektroniska journaler och patientgenererade data. Vi använder kausal inferens-metoder som Mendelsk randomisering, kausala diagram och propensity score-baserade metoder. Vi använder också maskininlärningsmetoder och utvecklar nya digitala metoder för klinisk forskning.
Gruppmedlemmar
Forskningsprojekt
- AI-baserad EKG-diagnostik av hjärtinfarkter
- Förbättra akutmottagningens säkerhet, effektivitet och kostnadseffektivitet genom artificiell intelligens (EmergAI)
- Hembaserad screening för hjärtsvikt (U-SCREEN-HF)
- Hitta hotande hjärtinfarkter (MIMI)
- Minforskning.se
- Skräddarsydd blodtrycksbehandling (PHYSIC)
- Storskalig analys av befolkningsstudier (Cohorts.se)
- U-SCREEN - Uppsala självscreening av hjärtkärlhälsa
Publikationer
Meat intake in relation to composition and function of gut microbiota
Ingår i Clinical Nutrition, s. 124-133, 2025
- DOI för Meat intake in relation to composition and function of gut microbiota
- Ladda ner fulltext (pdf) av Meat intake in relation to composition and function of gut microbiota
Ingår i EBioMedicine, 2025
- DOI för Cardio-metabolic-related plasma proteins reveal biological links between cardiovascular diseases and fragility fractures: a cohort and Mendelian randomisation investigation
- Ladda ner fulltext (pdf) av Cardio-metabolic-related plasma proteins reveal biological links between cardiovascular diseases and fragility fractures: a cohort and Mendelian randomisation investigation
Ingår i Circulation Heart Failure, 2024
Ingår i EBioMedicine, 2024
- DOI för Accelerometer-based physical activity is associated with the gut microbiota in 8416 individuals in SCAPIS
- Ladda ner fulltext (pdf) av Accelerometer-based physical activity is associated with the gut microbiota in 8416 individuals in SCAPIS
Ingår i Journal of the American Heart Association, 2024
- DOI för Self-Report Tool for Identification of Individuals With Coronary Atherosclerosis: The Swedish CardioPulmonary BioImage Study
- Ladda ner fulltext (pdf) av Self-Report Tool for Identification of Individuals With Coronary Atherosclerosis: The Swedish CardioPulmonary BioImage Study
Ingår i Annals of the American Thoracic Society, s. 1678-1687, 2024
- DOI för Chronic Airflow Limitation, Emphysema and Impaired Diffusing Capacity in Relation to Smoking Habits in a Swedish Middle-Aged Population
- Ladda ner fulltext (pdf) av Chronic Airflow Limitation, Emphysema and Impaired Diffusing Capacity in Relation to Smoking Habits in a Swedish Middle-Aged Population
Dietary patterns, untargeted metabolite profiles and their association with colorectal cancer risk
Ingår i Scientific Reports, 2024
- DOI för Dietary patterns, untargeted metabolite profiles and their association with colorectal cancer risk
- Ladda ner fulltext (pdf) av Dietary patterns, untargeted metabolite profiles and their association with colorectal cancer risk
Usefulness of Heart Failure Categories Based on Left Ventricular Ejection Fraction
Ingår i Journal of the American Heart Association, 2024
- DOI för Usefulness of Heart Failure Categories Based on Left Ventricular Ejection Fraction
- Ladda ner fulltext (pdf) av Usefulness of Heart Failure Categories Based on Left Ventricular Ejection Fraction
Ingår i BMC Health Services Research, 2024
- DOI för Factors predictive of hospital admission for children via emergency departments in Australia and Sweden: an observational cross-sectional study
- Ladda ner fulltext (pdf) av Factors predictive of hospital admission for children via emergency departments in Australia and Sweden: an observational cross-sectional study
Ingår i Circulation. Cardiovascular Quality and Outcomes, 2024
Ingår i Respiratory Research, 2024
- DOI för Exertional breathlessness related to medical conditions in middle-aged people: the population-based SCAPIS study of more than 25,000 men and women
- Ladda ner fulltext (pdf) av Exertional breathlessness related to medical conditions in middle-aged people: the population-based SCAPIS study of more than 25,000 men and women
Ingår i European Journal of Epidemiology, s. 35-49, 2024
- DOI för Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications
- Ladda ner fulltext (pdf) av Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications
Ingår i The Lancet Public Health, 2024
- DOI för Contemporary epidemiology of hospitalised heart failure with reduced versus preserved ejection fraction in England: a retrospective, cohort study of whole-population electronic health records
- Ladda ner fulltext (pdf) av Contemporary epidemiology of hospitalised heart failure with reduced versus preserved ejection fraction in England: a retrospective, cohort study of whole-population electronic health records
Ingår i Esophagus, s. 365-373, 2024
- DOI för Eosinophilic esophagitis and risk of incident major adverse cardiovascular events: a nationwide matched cohort study
- Ladda ner fulltext (pdf) av Eosinophilic esophagitis and risk of incident major adverse cardiovascular events: a nationwide matched cohort study
Ingår i American Journal of Clinical Nutrition, s. 187-195, 2024
- DOI för Substitutions of saturated fat intakes with other macronutrients and foods and risk of NAFLD cirrhosis and all-cause hepatocellular carcinoma: a prospective cohort study
- Ladda ner fulltext (pdf) av Substitutions of saturated fat intakes with other macronutrients and foods and risk of NAFLD cirrhosis and all-cause hepatocellular carcinoma: a prospective cohort study
Metabolic profiling of galectin-1 and galectin-3: a cross-sectional, multi-omics, association study
Ingår i International Journal of Obesity, s. 1180-1189, 2024
- DOI för Metabolic profiling of galectin-1 and galectin-3: a cross-sectional, multi-omics, association study
- Ladda ner fulltext (pdf) av Metabolic profiling of galectin-1 and galectin-3: a cross-sectional, multi-omics, association study
Ingår i Kidney international reports, s. 1849-1859, 2024
- DOI för Prioritization of Kidney Cell Types Highlights Myofibroblast Cells in Regulating Human Blood Pressure
- Ladda ner fulltext (pdf) av Prioritization of Kidney Cell Types Highlights Myofibroblast Cells in Regulating Human Blood Pressure
Ingår i Journal of Affective Disorders, s. 96-103, 2024
- DOI för Association between neighborhood socioeconomic status and healthcare utilization among individuals with a first diagnosis of major depressive disorder in primary care in the Stockholm region
- Ladda ner fulltext (pdf) av Association between neighborhood socioeconomic status and healthcare utilization among individuals with a first diagnosis of major depressive disorder in primary care in the Stockholm region
Analysis of plasma metabolomes from 11 309 subjects in five population-based cohorts
Ingår i Scientific Reports, s. 8933, 2024
- DOI för Analysis of plasma metabolomes from 11 309 subjects in five population-based cohorts
- Ladda ner fulltext (pdf) av Analysis of plasma metabolomes from 11 309 subjects in five population-based cohorts
Ingår i PLOS ONE, 2024
- DOI för The reproducibility of protocols used to mediate a current-induced vasodilation in the human cutaneous microcirculation
- Ladda ner fulltext (pdf) av The reproducibility of protocols used to mediate a current-induced vasodilation in the human cutaneous microcirculation
Ingår i JMIR Formative Research, 2024
- DOI för Person-Centered Web-Based Mobile Health System (Symptoms) for Reporting Symptoms in COVID-19 Vaccinated Individuals: Observational Study of System, Users, and Symptoms
- Ladda ner fulltext (pdf) av Person-Centered Web-Based Mobile Health System (Symptoms) for Reporting Symptoms in COVID-19 Vaccinated Individuals: Observational Study of System, Users, and Symptoms
Markers of imminent myocardial infarction
Ingår i Nature Cardiovascular Research, s. 130-139, 2024
- DOI för Markers of imminent myocardial infarction
- Ladda ner fulltext (pdf) av Markers of imminent myocardial infarction
More Evidence That HF With Normal EF Is Distinct From HF Below Normal EF
Ingår i Journal of the American College of Cardiology, s. 1740-1742, 2024
Ingår i Mayo Clinic proceedings, s. 69-80, 2024
- DOI för Life's Essential 8 and Life's Simple 7 in Relation to Coronary Atherosclerosis: Results From the Population-Based SCAPIS Project
- Ladda ner fulltext (pdf) av Life's Essential 8 and Life's Simple 7 in Relation to Coronary Atherosclerosis: Results From the Population-Based SCAPIS Project
Dapagliflozin in Myocardial Infarction without Diabetes or Heart Failure.
Ingår i NEJM evidence, 2024
Cardiopulmonary exercise testing and body composition.
Ingår i ERJ open research, 2024
Ingår i Nature Genetics, s. 778-791, 2024
- DOI för Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits
- Ladda ner fulltext (pdf) av Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits
Environmental contaminants, sex hormones and SHBG in an elderly population
Ingår i Environmental Research, 2024
Ingår i Epilepsia Open, s. 1611-1617, 2024
- DOI för Cardiovascular risk factor assessment in late-onset seizures: A study protocol to assess the value of structured intervention
- Ladda ner fulltext (pdf) av Cardiovascular risk factor assessment in late-onset seizures: A study protocol to assess the value of structured intervention
Cardiac biomarkers for detection of coronary artery disease in the community
Ingår i Scientific Reports, 2024
- DOI för Cardiac biomarkers for detection of coronary artery disease in the community
- Ladda ner fulltext (pdf) av Cardiac biomarkers for detection of coronary artery disease in the community
Ingår i NATURE CARDIOVASCULAR RESEARCH, s. 1189-1198, 2024
- DOI för Measured and genetically predicted protein levels and cardiovascular diseases in UK Biobank and China Kadoorie Biobank
- Ladda ner fulltext (pdf) av Measured and genetically predicted protein levels and cardiovascular diseases in UK Biobank and China Kadoorie Biobank
Ingår i European Journal of Heart Failure, s. 2453-2463, 2024
- DOI för The Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure with Preserved Ejection Fraction (SPIRRIT-HFpEF): Rationale and design
- Ladda ner fulltext (pdf) av The Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure with Preserved Ejection Fraction (SPIRRIT-HFpEF): Rationale and design
Ingår i European Heart Journal - Quality of Care and Clinical Outcomes, s. 641-649, 2024
- DOI för Regional assessment of availability for transcatheter aortic valve implantation in Sweden: a long-term observational study
- Ladda ner fulltext (pdf) av Regional assessment of availability for transcatheter aortic valve implantation in Sweden: a long-term observational study
Ingår i Stroke, s. 50-58, 2024
Ingår i BMC Oral Health, 2024
- DOI för Does smoking cessation affect postoperative healing following oral surgery among smokers?: a systematic review
- Ladda ner fulltext (pdf) av Does smoking cessation affect postoperative healing following oral surgery among smokers?: a systematic review
An association between heart rate variability and incident heart failure in an elderly cohort
Ingår i Clinical Cardiology, 2024
- DOI för An association between heart rate variability and incident heart failure in an elderly cohort
- Ladda ner fulltext (pdf) av An association between heart rate variability and incident heart failure in an elderly cohort
Ingår i European Stroke Journal, s. 295-302, 2024
- DOI för Acute care bundles should be used for patients with intracerebral haemorrhage: An expert consensus statement
- Ladda ner fulltext (pdf) av Acute care bundles should be used for patients with intracerebral haemorrhage: An expert consensus statement
Ingår i International Emergency Nursing, 2024
- DOI för Guidelines for patient care used by registered nurses in the emergency room: Mapping of Swedish governing documents
- Ladda ner fulltext (pdf) av Guidelines for patient care used by registered nurses in the emergency room: Mapping of Swedish governing documents
Ingår i BMC Emergency Medicine, 2024
- DOI för Fundamental care in the emergency room: insights from patients with life-threatening conditions in the emergency room
- Ladda ner fulltext (pdf) av Fundamental care in the emergency room: insights from patients with life-threatening conditions in the emergency room
Reference ranges for ambulatory heart rate measurements in a middle-aged population
Ingår i Heart, s. 831-837, 2024
- DOI för Reference ranges for ambulatory heart rate measurements in a middle-aged population
- Ladda ner fulltext (pdf) av Reference ranges for ambulatory heart rate measurements in a middle-aged population
Ingår i The Lancet, s. 1027-1050, 2024
- DOI för Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
- Ladda ner fulltext (pdf) av Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
Ingår i Environment International, 2024
- DOI för Socio-demographic inequalities influence differences in the chemical exposome among Swedish adolescents
- Ladda ner fulltext (pdf) av Socio-demographic inequalities influence differences in the chemical exposome among Swedish adolescents
Ingår i BMC Pulmonary Medicine, 2024
- DOI för Bioelectrical impedance and lung function - associations with gender and central obesity: results of the EpiHealth study
- Ladda ner fulltext (pdf) av Bioelectrical impedance and lung function - associations with gender and central obesity: results of the EpiHealth study
Ingår i Journal of Mass Spectrometry, 2024
- DOI för Assessing the performance of a targeted absolute quantification isotope dilution liquid chromatograhy tandem mass spectrometry assay versus a commercial nontargeted relative quantification assay for detection of three major perfluoroalkyls in human blood
- Ladda ner fulltext (pdf) av Assessing the performance of a targeted absolute quantification isotope dilution liquid chromatograhy tandem mass spectrometry assay versus a commercial nontargeted relative quantification assay for detection of three major perfluoroalkyls in human blood
Ingår i BMC Public Health, 2024
- DOI för The state of health in the European Union (EU-27) in 2019: a systematic analysis for the Global Burden of Disease study 2019
- Ladda ner fulltext (pdf) av The state of health in the European Union (EU-27) in 2019: a systematic analysis for the Global Burden of Disease study 2019
Ingår i Journal of Tissue Viability, s. 701-705, 2024
- DOI för Prevention of pressure ulcers from the perspective of frailty, pre-frailty, and health and social inequalities: An opinion paper
- Ladda ner fulltext (pdf) av Prevention of pressure ulcers from the perspective of frailty, pre-frailty, and health and social inequalities: An opinion paper
Ingår i The Lancet Diabetes and Endocrinology, 2024
- DOI för Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses
- Ladda ner fulltext (pdf) av Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses
Ingår i American Journal of Gastroenterology, s. 1866-1874, 2024
Risk of heart failure in inflammatory bowel disease: a Swedish population-based study
Ingår i European Heart Journal, s. 2493-2504, 2024
- DOI för Risk of heart failure in inflammatory bowel disease: a Swedish population-based study
- Ladda ner fulltext (pdf) av Risk of heart failure in inflammatory bowel disease: a Swedish population-based study
Ingår i Gut, 2024
Anders Wiklöf-institutet för hjärtforskning
Anders Wiklöf-institutet för hjärtforskning är en fokuserad forskningssatsning med målet att bättre kunna förutse och förhindra hjärt-kärlsjukdomar. Institutet har kunnat starta tack vare en donation av den åländske affärsmannen Anders Wiklöf. Vid institutet möter experter inom hjärt-kärlsjukdomar experter inom datavetenskaper, artificiell intelligens (AI), statistik, innovation, och förvaltning och tillgängliggörande av medicinska datamängder.
Läs mer om Anders Wiklöf-institutet för hjärtforskning (AWI)
Anders Wiklöf-institutet för hjärtforskning på besök hos Ålands lyceum