Clinical Epidemiology

Our passion is using big data to create value for patients and populations.
Description of our research

Professor Johan Sundström. Photo: Mikael Wallerstedt.
Our research group is leading a national strategic research program in epidemiology funded by the Swedish government. We utilize many of Sweden’s cohorts in our observational research and have collected many of them ourselves, and we are leading a national initiative to increase the value of all Swedish cohorts. We also lead randomized clinical trials, mainly in cardiometabolic diseases and emergency care, and conduct systematic reviews and meta-analyses.
Our methods and method development are focused on using big data to guide risk estimation, treatment decisions, and evaluation of treatment effects, risks and costs. In addition to traditional data sources such as clinical trials and cohorts with multiple omics data, we use emerging ones such as electronic health records and patient-generated data. We use causal inference methods such as Mendelian randomization, causal diagrams, and propensity score-based methods. We also use machine learning methods and develop new digital tools for clinical research.
Gruppmedlemmar
Research projects
- AI-based ECG diagnosis of heart attacks
- Home-based screening for heart failure (U-SCREEN-HF)
- Improving emergency department safety, efficiency and cost effectiveness through artificial intelligence (EmergAI)
- Large-scale analysis of population studies (Cohorts.se)
- Markers of Imminent Myocardial Infarction (MIMI)
- Minforskning.se
- Personalised blood pressure treatment (PHYSIC)
- U-SCREEN - Uppsala self-screening of cardiovascular health
Publications
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Standardized Mortality Ratio and Long-Term Stroke Incidence After PFO Closure: A Register Study
Part of JACC: Advances, 2026
- DOI for Standardized Mortality Ratio and Long-Term Stroke Incidence After PFO Closure: A Register Study
- Download full text (pdf) of Standardized Mortality Ratio and Long-Term Stroke Incidence After PFO Closure: A Register Study
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Part of Scientific Reports, 2026
- DOI for A latent class analysis of cardiometabolic risk factors and the predicted prevalence of subclinical atherosclerosis in middle-aged Swedish adults
- Download full text (pdf) of A latent class analysis of cardiometabolic risk factors and the predicted prevalence of subclinical atherosclerosis in middle-aged Swedish adults
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Part of Nature Medicine, p. 1351-1361, 2026
- DOI for Antibiotic use and gut microbiome composition links from individual-level prescription data of 14,979 individuals
- Download full text (pdf) of Antibiotic use and gut microbiome composition links from individual-level prescription data of 14,979 individuals
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Coronary Computed Tomography Angiography in Prediction of First Coronary Events
Part of Journal of the American Medical Association (JAMA), p. 245-254, 2026
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Frail Older Patients' Experiences During Boarding in the Emergency Department: A Qualitative Study
Part of Journal of Advanced Nursing, p. 5244-5255, 2026
- DOI for Frail Older Patients' Experiences During Boarding in the Emergency Department: A Qualitative Study
- Download full text (pdf) of Frail Older Patients' Experiences During Boarding in the Emergency Department: A Qualitative Study
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Part of Pharmacoepidemiology and Drug Safety, 2026
- DOI for Methodological Challenges of Emulating a Target Trial to Assess Effectiveness of Timing of PCSK9 Inhibitor Treatment Initiation Post Myocardial Infarction
- Download full text (pdf) of Methodological Challenges of Emulating a Target Trial to Assess Effectiveness of Timing of PCSK9 Inhibitor Treatment Initiation Post Myocardial Infarction
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GWAS and Replication Analysis of Apparent Treatment-Resistant Hypertension
Part of Hypertension, 2026
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Part of BMC Medicine, 2026
- DOI for Adolescent intelligence and imaging-detected atherosclerosis in middle age: a population study of Swedish men
- Download full text (pdf) of Adolescent intelligence and imaging-detected atherosclerosis in middle age: a population study of Swedish men
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Part of Diabetes, obesity and metabolism, p. 1327-1338, 2026
- DOI for SGLT2 inhibitor or metformin as standard treatment in early-stage type 2 diabetes? Baseline data in SMARTEST, a novel, decentralised, register-based randomised trial on prevention of diabetic complications
- Download full text (pdf) of SGLT2 inhibitor or metformin as standard treatment in early-stage type 2 diabetes? Baseline data in SMARTEST, a novel, decentralised, register-based randomised trial on prevention of diabetic complications
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Part of European Stroke Journal, 2026
- DOI for Early versus delayed DOAC after ischaemic stroke in atrial fibrillation: 1-year outcomes in the TIMING study and in concurrent practice
- Download full text (pdf) of Early versus delayed DOAC after ischaemic stroke in atrial fibrillation: 1-year outcomes in the TIMING study and in concurrent practice
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Part of Scientific Reports, 2026
- DOI for Plasma neuropilin-1 is associated with a favorable lipid profile and insulin sensitivity in a population-based sample of 50-year-old individuals
- Download full text (pdf) of Plasma neuropilin-1 is associated with a favorable lipid profile and insulin sensitivity in a population-based sample of 50-year-old individuals
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Part of Therapeutic Advances in Gastroenterology, 2026
- DOI for Association of inflammatory bowel disease with cardiovascular disease, and the mediating role of inflammation: a matched-cohort study
- Download full text (pdf) of Association of inflammatory bowel disease with cardiovascular disease, and the mediating role of inflammation: a matched-cohort study
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Part of Journal of Hypertension, p. 346-353, 2026
- DOI for Systolic inter-arm blood pressure difference and subclinical atherosclerosis: a population-based cohort study of 29 921 individuals
- Download full text (pdf) of Systolic inter-arm blood pressure difference and subclinical atherosclerosis: a population-based cohort study of 29 921 individuals
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A deep learning ECG model for identification and localization of occlusion myocardial infarction
Part of Nature Communications, 2026
- DOI for A deep learning ECG model for identification and localization of occlusion myocardial infarction
- Download full text (pdf) of A deep learning ECG model for identification and localization of occlusion myocardial infarction
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Part of Hypertension, p. 167-176, 2026
- DOI for Consistency of Blood Pressure Response to Potassium-Enriched Salt in the China Salt Substitute Study.
- Download full text (pdf) of Consistency of Blood Pressure Response to Potassium-Enriched Salt in the China Salt Substitute Study.
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Part of Journal of Investigative Dermatology, 2026
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Part of eClinicalMedicine, 2026
- DOI for Persistence to antihypertensive drug classes in uncomplicated hypertension: a nationwide Swedish cohort study
- Download full text (pdf) of Persistence to antihypertensive drug classes in uncomplicated hypertension: a nationwide Swedish cohort study
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Part of Nature Medicine, p. 1454-1478, 2026
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Plasma protein profiles in different heart failure phenotypes
Part of ESC Heart Failure, 2026
- DOI for Plasma protein profiles in different heart failure phenotypes
- Download full text (pdf) of Plasma protein profiles in different heart failure phenotypes
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Cardiomyopathies: Nationwide Trends in Prevalence, Incidence, and Mortality (2004-2023)
Part of Journal of the American College of Cardiology, p. 1087-1090, 2026
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Part of Acta Obstetricia et Gynecologica Scandinavica, p. 466-478, 2026
- DOI for Differences in prediction of adverse perinatal outcome in term pregnancies by choice of fetal growth reference: A validation study
- Download full text (pdf) of Differences in prediction of adverse perinatal outcome in term pregnancies by choice of fetal growth reference: A validation study
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Impact of kidney function on the metabolome in the general population
Part of PLOS ONE, 2026
- DOI for Impact of kidney function on the metabolome in the general population
- Download full text (pdf) of Impact of kidney function on the metabolome in the general population
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Part of European journal of emergency medicine, p. 138-138, 2026
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Part of European journal of emergency medicine, p. 18-23, 2026
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Part of BMC Nursing, 2026
- DOI for Opening Pandora's box in the emergency room: a secondary analysis of existential needs from observational, registered nurse, and patient perspectives
- Download full text (pdf) of Opening Pandora's box in the emergency room: a secondary analysis of existential needs from observational, registered nurse, and patient perspectives
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Part of Cell Reports, 2026
- DOI for RAB3GAP2 is a regulator of skeletal muscle endothelial cell proliferation and associated with capillary-to-fiber ratio
- Download full text (pdf) of RAB3GAP2 is a regulator of skeletal muscle endothelial cell proliferation and associated with capillary-to-fiber ratio
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Obesity rise plateaus in developed nations and accelerates in developing nations
Part of Nature, p. 510-518, 2026
- DOI for Obesity rise plateaus in developed nations and accelerates in developing nations
- Download full text (pdf) of Obesity rise plateaus in developed nations and accelerates in developing nations
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Part of Environment International, 2026
- DOI for An exploratory study of environmental and nutritional determinants of early-stage clonal hematopoiesis in the elderly
- Download full text (pdf) of An exploratory study of environmental and nutritional determinants of early-stage clonal hematopoiesis in the elderly
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Part of BMJ Open, 2025
- DOI for Effect of the FoodSwitch application on type 2 diabetes in Sweden: a study protocol for the randomised controlled DIgitAl diabeTES Treatment - the Healthy Eating, heaLthy Patients trial (DIATEST-HELP)
- Download full text (pdf) of Effect of the FoodSwitch application on type 2 diabetes in Sweden: a study protocol for the randomised controlled DIgitAl diabeTES Treatment - the Healthy Eating, heaLthy Patients trial (DIATEST-HELP)
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Impact of genetic variants linked to liver fat and liver volume on MRI-mapped body composition
Part of JHEP Reports, 2025
- DOI for Impact of genetic variants linked to liver fat and liver volume on MRI-mapped body composition
- Download full text (pdf) of Impact of genetic variants linked to liver fat and liver volume on MRI-mapped body composition
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Part of Läkartidningen, 2025
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Part of International Journal for Equity in Health, 2025
- DOI for Socio-geographical disparities in cardiometabolic multimorbidity in Sweden: an Intersectional Multilevel Analysis of Individual Heterogeneity and Discriminatory Accuracy (I-MAIHDA)
- Download full text (pdf) of Socio-geographical disparities in cardiometabolic multimorbidity in Sweden: an Intersectional Multilevel Analysis of Individual Heterogeneity and Discriminatory Accuracy (I-MAIHDA)
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Part of Metabolism, 2025
- DOI for Plasma metabolite profiles of meat intake and their association with cardiovascular disease risk: A population-based study in Swedish cohorts
- Download full text (pdf) of Plasma metabolite profiles of meat intake and their association with cardiovascular disease risk: A population-based study in Swedish cohorts
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Part of Metabolism, 2025
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Part of Atherosclerosis, 2025
- DOI for Different plasma biomarker patterns associated with coronary atherosclerosis in low- versus high-risk individuals: - an observational cross-sectional study
- Download full text (pdf) of Different plasma biomarker patterns associated with coronary atherosclerosis in low- versus high-risk individuals: - an observational cross-sectional study
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Part of Neuroscience and Biobehavioral Reviews, 2025
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Part of Cardiovascular Research, p. 2360-2373, 2025
- DOI for A multi-omics approach uncovers causality of IL6R on endotypes of subclinical carotid atherosclerosis and the possible role of the IL6R/OSMR pathway
- Download full text (pdf) of A multi-omics approach uncovers causality of IL6R on endotypes of subclinical carotid atherosclerosis and the possible role of the IL6R/OSMR pathway
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Part of The Lancet, p. 43-51, 2025
- DOI for Collaboration on the optimal timing of anticoagulation after ischaemic stroke and atrial fibrillation: a systematic review and prospective individual participant data meta-analysis of randomised controlled trials (CATALYST)
- Download full text (pdf) of Collaboration on the optimal timing of anticoagulation after ischaemic stroke and atrial fibrillation: a systematic review and prospective individual participant data meta-analysis of randomised controlled trials (CATALYST)
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Part of Heart, p. 300-305, 2025
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Associations between physical activity and CVD-related metabolomic and proteomic biomarkers
Part of PLOS ONE, 2025
- DOI for Associations between physical activity and CVD-related metabolomic and proteomic biomarkers
- Download full text (pdf) of Associations between physical activity and CVD-related metabolomic and proteomic biomarkers
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Implementing electronic informed consent in rare disease genomics
Part of Scientific Reports, 2025
- DOI for Implementing electronic informed consent in rare disease genomics
- Download full text (pdf) of Implementing electronic informed consent in rare disease genomics
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Part of Clinical Kidney Journal, 2025
- DOI for Causal effects of obesity on estimated glomerular filtration rate: a Mendelian randomization and image data analysis study
- Download full text (pdf) of Causal effects of obesity on estimated glomerular filtration rate: a Mendelian randomization and image data analysis study
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Part of Cardiovascular Research, p. 1649-1652, 2025
- DOI for Plasma proteomic and metabolomic profiling of coronary and carotid atherosclerosis in the SCAPIS study: differences and similarities
- Download full text (pdf) of Plasma proteomic and metabolomic profiling of coronary and carotid atherosclerosis in the SCAPIS study: differences and similarities
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Part of European Heart Journal - Quality of Care and Clinical Outcomes, p. 415-423, 2025
- DOI for Diverticular disease and risk of incident major adverse cardiovascular events: a nationwide matched cohort study
- Download full text (pdf) of Diverticular disease and risk of incident major adverse cardiovascular events: a nationwide matched cohort study
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Part of Nature Communications, 2025
- DOI for Effects of an anti-lipogenic low-carbohydrate high polyunsaturated fat diet or a healthy Nordic diet versus usual care on liver fat and cardiometabolic disorders in type 2 diabetes or prediabetes: a randomized controlled trial (NAFLDiet)
- Download full text (pdf) of Effects of an anti-lipogenic low-carbohydrate high polyunsaturated fat diet or a healthy Nordic diet versus usual care on liver fat and cardiometabolic disorders in type 2 diabetes or prediabetes: a randomized controlled trial (NAFLDiet)
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A genome-wide association study of imaging-defined atherosclerosis
Part of Nature Communications, 2025
- DOI for A genome-wide association study of imaging-defined atherosclerosis
- Download full text (pdf) of A genome-wide association study of imaging-defined atherosclerosis
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Part of The Lancet, p. 1873-1922, 2025
- DOI for Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
- Download full text (pdf) of Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
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Part of Nature Genetics, p. 815-828, 2025
- DOI for Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes
- Download full text (pdf) of Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes
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Part of Scandinavian Cardiovascular Journal, 2025
- DOI for Prevalence of atrial fibrillation among Swedish adults participating in the general population study EpiHealth
- Download full text (pdf) of Prevalence of atrial fibrillation among Swedish adults participating in the general population study EpiHealth
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Studentlitteratur AB, 2025
The Anders Wiklöf Institute for Heart Research
The Anders Wiklöf Institute for Heart Research is a focused research initiative striving towards improved prediction and prevention of cardiovascular diseases. The Institute was made possible through a donation by Åland businessman Anders Wiklöf. The Institute brings together experts in cardiovascular diseases, computer science, artificial intelligence (AI), statistics, innovation, and the administration and accessibility of medical data.
Read more about the the Anders Wiklöf Institute for Heart Research (AWI)
The Anders Wiklöf Institute for Heart Research visits Ålands Lyceum