Clinical Epidemiology

Our passion is using big data to create value for patients and populations.
Description of our research

Professor Johan Sundström. Photo: Mikael Wallerstedt.
Our research group is leading a national strategic research program in epidemiology funded by the Swedish government. We utilize many of Sweden’s cohorts in our observational research and have collected many of them ourselves, and we are leading a national initiative to increase the value of all Swedish cohorts. We also lead randomized clinical trials, mainly in cardiometabolic diseases and emergency care, and conduct systematic reviews and meta-analyses.
Our methods and method development are focused on using big data to guide risk estimation, treatment decisions, and evaluation of treatment effects, risks and costs. In addition to traditional data sources such as clinical trials and cohorts with multiple omics data, we use emerging ones such as electronic health records and patient-generated data. We use causal inference methods such as Mendelian randomization, causal diagrams, and propensity score-based methods. We also use machine learning methods and develop new digital tools for clinical research.
Group members
Research projects
- AI-based ECG diagnosis of heart attacks
- Home-based screening for heart failure (U-SCREEN-HF)
- Improving emergency department safety, efficiency and cost effectiveness through artificial intelligence (EmergAI)
- Large-scale analysis of population studies (Cohorts.se)
- Markers of Imminent Myocardial Infarction (MIMI)
- Minforskning.se
- Personalised blood pressure treatment (PHYSIC)
- U-SCREEN - Uppsala self-screening of cardiovascular health
Publications
Part of Metabolism, 2025
- DOI for Plasma metabolite profiles of meat intake and their association with cardiovascular disease risk: A population-based study in Swedish cohorts
- Download full text (pdf) of Plasma metabolite profiles of meat intake and their association with cardiovascular disease risk: A population-based study in Swedish cohorts
Part of Neuroscience and Biobehavioral Reviews, 2025
Meat intake in relation to composition and function of gut microbiota
Part of Clinical Nutrition, p. 124-133, 2025
- DOI for Meat intake in relation to composition and function of gut microbiota
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Part of EBioMedicine, 2025
- DOI for Cardio-metabolic-related plasma proteins reveal biological links between cardiovascular diseases and fragility fractures: a cohort and Mendelian randomisation investigation
- Download full text (pdf) of Cardio-metabolic-related plasma proteins reveal biological links between cardiovascular diseases and fragility fractures: a cohort and Mendelian randomisation investigation
Part of European Journal of Heart Failure, p. 180-181, 2025
The Lancet Commission on rethinking coronary artery disease: moving from ischaemia to atheroma
Part of The Lancet, p. 1264-1312, 2025
Part of Circulation Heart Failure, 2024
Part of EBioMedicine, 2024
- DOI for Accelerometer-based physical activity is associated with the gut microbiota in 8416 individuals in SCAPIS
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Part of Journal of the American Heart Association, 2024
- DOI for Self-Report Tool for Identification of Individuals With Coronary Atherosclerosis: The Swedish CardioPulmonary BioImage Study
- Download full text (pdf) of Self-Report Tool for Identification of Individuals With Coronary Atherosclerosis: The Swedish CardioPulmonary BioImage Study
Part of Annals of the American Thoracic Society, p. 1678-1687, 2024
- DOI for Chronic Airflow Limitation, Emphysema and Impaired Diffusing Capacity in Relation to Smoking Habits in a Swedish Middle-Aged Population
- Download full text (pdf) of Chronic Airflow Limitation, Emphysema and Impaired Diffusing Capacity in Relation to Smoking Habits in a Swedish Middle-Aged Population
Dietary patterns, untargeted metabolite profiles and their association with colorectal cancer risk
Part of Scientific Reports, 2024
- DOI for Dietary patterns, untargeted metabolite profiles and their association with colorectal cancer risk
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Usefulness of Heart Failure Categories Based on Left Ventricular Ejection Fraction
Part of Journal of the American Heart Association, 2024
- DOI for Usefulness of Heart Failure Categories Based on Left Ventricular Ejection Fraction
- Download full text (pdf) of Usefulness of Heart Failure Categories Based on Left Ventricular Ejection Fraction
Part of BMC Health Services Research, 2024
- DOI for Factors predictive of hospital admission for children via emergency departments in Australia and Sweden: an observational cross-sectional study
- Download full text (pdf) of Factors predictive of hospital admission for children via emergency departments in Australia and Sweden: an observational cross-sectional study
Part of Circulation. Cardiovascular Quality and Outcomes, 2024
Part of Respiratory Research, 2024
- DOI for Exertional breathlessness related to medical conditions in middle-aged people: the population-based SCAPIS study of more than 25,000 men and women
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Part of European Journal of Epidemiology, p. 35-49, 2024
- DOI for Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications
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Part of The Lancet Public Health, 2024
- DOI for Contemporary epidemiology of hospitalised heart failure with reduced versus preserved ejection fraction in England: a retrospective, cohort study of whole-population electronic health records
- Download full text (pdf) of Contemporary epidemiology of hospitalised heart failure with reduced versus preserved ejection fraction in England: a retrospective, cohort study of whole-population electronic health records
Part of Esophagus, p. 365-373, 2024
- DOI for Eosinophilic esophagitis and risk of incident major adverse cardiovascular events: a nationwide matched cohort study
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Part of American Journal of Clinical Nutrition, p. 187-195, 2024
- DOI for Substitutions of saturated fat intakes with other macronutrients and foods and risk of NAFLD cirrhosis and all-cause hepatocellular carcinoma: a prospective cohort study
- Download full text (pdf) of Substitutions of saturated fat intakes with other macronutrients and foods and risk of NAFLD cirrhosis and all-cause hepatocellular carcinoma: a prospective cohort study
Metabolic profiling of galectin-1 and galectin-3: a cross-sectional, multi-omics, association study
Part of International Journal of Obesity, p. 1180-1189, 2024
- DOI for Metabolic profiling of galectin-1 and galectin-3: a cross-sectional, multi-omics, association study
- Download full text (pdf) of Metabolic profiling of galectin-1 and galectin-3: a cross-sectional, multi-omics, association study
Part of Kidney international reports, p. 1849-1859, 2024
- DOI for Prioritization of Kidney Cell Types Highlights Myofibroblast Cells in Regulating Human Blood Pressure
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Part of Journal of Affective Disorders, p. 96-103, 2024
- DOI for Association between neighborhood socioeconomic status and healthcare utilization among individuals with a first diagnosis of major depressive disorder in primary care in the Stockholm region
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Analysis of plasma metabolomes from 11 309 subjects in five population-based cohorts
Part of Scientific Reports, p. 8933, 2024
- DOI for Analysis of plasma metabolomes from 11 309 subjects in five population-based cohorts
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Part of PLOS ONE, 2024
- DOI for The reproducibility of protocols used to mediate a current-induced vasodilation in the human cutaneous microcirculation
- Download full text (pdf) of The reproducibility of protocols used to mediate a current-induced vasodilation in the human cutaneous microcirculation
Part of JMIR Formative Research, 2024
- DOI for Person-Centered Web-Based Mobile Health System (Symptoms) for Reporting Symptoms in COVID-19 Vaccinated Individuals: Observational Study of System, Users, and Symptoms
- Download full text (pdf) of Person-Centered Web-Based Mobile Health System (Symptoms) for Reporting Symptoms in COVID-19 Vaccinated Individuals: Observational Study of System, Users, and Symptoms
Markers of imminent myocardial infarction
Part of Nature Cardiovascular Research, p. 130-139, 2024
- DOI for Markers of imminent myocardial infarction
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More Evidence That HF With Normal EF Is Distinct From HF Below Normal EF
Part of Journal of the American College of Cardiology, p. 1740-1742, 2024
Part of Mayo Clinic proceedings, p. 69-80, 2024
- DOI for Life's Essential 8 and Life's Simple 7 in Relation to Coronary Atherosclerosis: Results From the Population-Based SCAPIS Project
- Download full text (pdf) of Life's Essential 8 and Life's Simple 7 in Relation to Coronary Atherosclerosis: Results From the Population-Based SCAPIS Project
Dapagliflozin in Myocardial Infarction without Diabetes or Heart Failure.
Part of NEJM evidence, 2024
Cardiopulmonary exercise testing and body composition.
Part of ERJ open research, 2024
Part of Nature Genetics, p. 778-791, 2024
- DOI for Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits
- Download full text (pdf) of Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits
Environmental contaminants, sex hormones and SHBG in an elderly population
Part of Environmental Research, 2024
Part of Epilepsia Open, p. 1611-1617, 2024
- DOI for Cardiovascular risk factor assessment in late-onset seizures: A study protocol to assess the value of structured intervention
- Download full text (pdf) of Cardiovascular risk factor assessment in late-onset seizures: A study protocol to assess the value of structured intervention
Cardiac biomarkers for detection of coronary artery disease in the community
Part of Scientific Reports, 2024
- DOI for Cardiac biomarkers for detection of coronary artery disease in the community
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Part of NATURE CARDIOVASCULAR RESEARCH, p. 1189-1198, 2024
- DOI for Measured and genetically predicted protein levels and cardiovascular diseases in UK Biobank and China Kadoorie Biobank
- Download full text (pdf) of Measured and genetically predicted protein levels and cardiovascular diseases in UK Biobank and China Kadoorie Biobank
Part of European Journal of Heart Failure, p. 2453-2463, 2024
- DOI for The Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure with Preserved Ejection Fraction (SPIRRIT-HFpEF): Rationale and design
- Download full text (pdf) of The Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure with Preserved Ejection Fraction (SPIRRIT-HFpEF): Rationale and design
Part of European Heart Journal - Quality of Care and Clinical Outcomes, p. 641-649, 2024
- DOI for Regional assessment of availability for transcatheter aortic valve implantation in Sweden: a long-term observational study
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Part of Stroke, p. 50-58, 2024
Part of BMC Oral Health, 2024
- DOI for Does smoking cessation affect postoperative healing following oral surgery among smokers?: a systematic review
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An association between heart rate variability and incident heart failure in an elderly cohort
Part of Clinical Cardiology, 2024
- DOI for An association between heart rate variability and incident heart failure in an elderly cohort
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Part of European Stroke Journal, p. 295-302, 2024
- DOI for Acute care bundles should be used for patients with intracerebral haemorrhage: An expert consensus statement
- Download full text (pdf) of Acute care bundles should be used for patients with intracerebral haemorrhage: An expert consensus statement
Part of International Emergency Nursing, 2024
- DOI for Guidelines for patient care used by registered nurses in the emergency room: Mapping of Swedish governing documents
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Part of BMC Emergency Medicine, 2024
- DOI for Fundamental care in the emergency room: insights from patients with life-threatening conditions in the emergency room
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Reference ranges for ambulatory heart rate measurements in a middle-aged population
Part of Heart, p. 831-837, 2024
- DOI for Reference ranges for ambulatory heart rate measurements in a middle-aged population
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Part of The Lancet, p. 1027-1050, 2024
- DOI for Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
- Download full text (pdf) of Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
Part of Environment International, 2024
- DOI for Socio-demographic inequalities influence differences in the chemical exposome among Swedish adolescents
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Part of BMC Pulmonary Medicine, 2024
- DOI for Bioelectrical impedance and lung function - associations with gender and central obesity: results of the EpiHealth study
- Download full text (pdf) of Bioelectrical impedance and lung function - associations with gender and central obesity: results of the EpiHealth study
Part of Journal of Mass Spectrometry, 2024
- DOI for Assessing the performance of a targeted absolute quantification isotope dilution liquid chromatograhy tandem mass spectrometry assay versus a commercial nontargeted relative quantification assay for detection of three major perfluoroalkyls in human blood
- Download full text (pdf) of Assessing the performance of a targeted absolute quantification isotope dilution liquid chromatograhy tandem mass spectrometry assay versus a commercial nontargeted relative quantification assay for detection of three major perfluoroalkyls in human blood
Part of BMC Public Health, 2024
- DOI for The state of health in the European Union (EU-27) in 2019: a systematic analysis for the Global Burden of Disease study 2019
- Download full text (pdf) of The state of health in the European Union (EU-27) in 2019: a systematic analysis for the Global Burden of Disease study 2019
Part of Journal of Tissue Viability, p. 701-705, 2024
- DOI for Prevention of pressure ulcers from the perspective of frailty, pre-frailty, and health and social inequalities: An opinion paper
- Download full text (pdf) of Prevention of pressure ulcers from the perspective of frailty, pre-frailty, and health and social inequalities: An opinion paper
The Anders Wiklöf Institute for Heart Research
The Anders Wiklöf Institute for Heart Research is a focused research initiative striving towards improved prediction and prevention of cardiovascular diseases. The Institute was made possible through a donation by Åland businessman Anders Wiklöf. The Institute brings together experts in cardiovascular diseases, computer science, artificial intelligence (AI), statistics, innovation, and the administration and accessibility of medical data.
Read more about the the Anders Wiklöf Institute for Heart Research (AWI)
The Anders Wiklöf Institute for Heart Research visits Ålands Lyceum