Neurologi

Forskningsaktiviteten på enheten för neurologi är starkt patientorienterad. I den kliniska verksamheten väcks dagligen vetenskapliga frågor vilka vi försöker lösa med stöd av resultat från bl.a. interventions-, observations- och epidemiologiska studier samt translationella studier där material från biobank används.
Beskrivning av vår forskning
Våra forskningsområden inkluderar vanliga neurologiska sjukdomar som epilepsi, motorikstörningar, akut stroke och multipel skleros, men också sömnsjukdomar, som narkolepsi, och ännu mer ovanliga tillstånd som neurogenetiska sjukdomar, till exempel Huntingtons sjukdom och låggradiga gliom. Områden som störningar i autonoma nervsystemet och utveckling av behandlingar har varit framträdande sedan länge.
Ett gemensamt fokus kan innefattas i begreppet ”Neuroterapi”, där vår enhet sedan länge befäst en stark ställning för att utveckla behandling vid sjukdom. Sådana exempel är läkemedelsbehandling med pump vid svår Parkinsons sjukdom, epilepsikirurgi och stamcellstransplantation mot MS, vidare avancerad bilddiagnostik vid kartläggning av hjärntumörer, samt shuntoperation vid normaltryckshydrocefalus (NPH).
Gruppmedlemmar
Forskningsprojekt
- Huntingtons sjukdom och andra neurogenetiska sjukdomar
- ALS och andra motorneuronsjukdomar
- Epilepsi
- MS och andra neuroinflammatoriska sjukdomar
- Normaltryckshydrocefalus och andra likvorcirkulationsstörinngar
- Parkinsons sjukdom och andra rörelsestörningar
- Stroke och andra cerebrovaskulära sjukdomar
Publikationer
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Ingår i NeuroImage, 2026
- DOI för A data-driven SSM/PCA analysis approach for differential diagnosis of parkinsonism using 11C-PE2I PET
- Ladda ner fulltext (pdf) av A data-driven SSM/PCA analysis approach for differential diagnosis of parkinsonism using 11C-PE2I PET
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Ingår i Brain Communications, 2026
- DOI för Assessing CT-based volumetric analysis via deep learning for idiopathic normal pressure hydrocephalus
- Ladda ner fulltext (pdf) av Assessing CT-based volumetric analysis via deep learning for idiopathic normal pressure hydrocephalus
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Burden among participants with central disorders of hypersomnolence in six European countries
Ingår i Sleep Medicine, 2026
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Cerebrospinal Fluid Biomarkers in Idiopathic Normal Pressure Hydrocephalus
2026
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Characterization of a distinct form of vimentin in the neurodegenerative brain
Ingår i Acta neuropathologica communications, 2026
- DOI för Characterization of a distinct form of vimentin in the neurodegenerative brain
- Ladda ner fulltext (pdf) av Characterization of a distinct form of vimentin in the neurodegenerative brain
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Ingår i Journal of the Neurological Sciences, 2026
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Ingår i Parkinsonism & Related Disorders, 2026
- DOI för Comparative outcomes and healthcare costs of three device-aided pharmacotherapies for patients with advanced Parkinson's disease in Sweden: A nationwide registry-based cohort study
- Ladda ner fulltext (pdf) av Comparative outcomes and healthcare costs of three device-aided pharmacotherapies for patients with advanced Parkinson's disease in Sweden: A nationwide registry-based cohort study
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Ingår i Journal of neural transmission, s. 361-375, 2026
- DOI för COMT inhibition with entacapone for patients with Parkinson’s disease and motor complications: the novelty of continuous infusion
- Ladda ner fulltext (pdf) av COMT inhibition with entacapone for patients with Parkinson’s disease and motor complications: the novelty of continuous infusion
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Ingår i Muscle and Nerve, s. 92-102, 2026
- DOI för Digital Phenotyping and Lifestyle Intervention in Patients With Myasthenia Gravis (DIG-MG): A Randomized Controlled Trial of Feasibility, Adherence, and Effects on Fatigue
- Ladda ner fulltext (pdf) av Digital Phenotyping and Lifestyle Intervention in Patients With Myasthenia Gravis (DIG-MG): A Randomized Controlled Trial of Feasibility, Adherence, and Effects on Fatigue
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Ingår i European Stroke Journal, 2026
- DOI för Early versus delayed DOAC after ischaemic stroke in atrial fibrillation: 1-year outcomes in the TIMING study and in concurrent practice
- Ladda ner fulltext (pdf) av Early versus delayed DOAC after ischaemic stroke in atrial fibrillation: 1-year outcomes in the TIMING study and in concurrent practice
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Ingår i Acta Neurologica Scandinavica, 2026
- DOI för Follow-Up of Clinical Symptoms, Neuronal Biomarkers, and Antibodies in Patients With COVID-19 and Neurological Manifestations
- Ladda ner fulltext (pdf) av Follow-Up of Clinical Symptoms, Neuronal Biomarkers, and Antibodies in Patients With COVID-19 and Neurological Manifestations
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Ingår i Brain, s. 951-962, 2026
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Inflammatory protein profiles and shunt response in iNPH
Ingår i Fluids and Barriers of the CNS, 2026
- DOI för Inflammatory protein profiles and shunt response in iNPH
- Ladda ner fulltext (pdf) av Inflammatory protein profiles and shunt response in iNPH
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Lifetime risk of cancer in carriers of intermediate alleles in the HTT gene
Ingår i Scientific Reports, 2026
- DOI för Lifetime risk of cancer in carriers of intermediate alleles in the HTT gene
- Ladda ner fulltext (pdf) av Lifetime risk of cancer in carriers of intermediate alleles in the HTT gene
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Long-term neuromuscular alterations during botulinum toxin treatment for chronic migraine
Ingår i Clinical Neurophysiology Practice, s. 503-511, 2026
- DOI för Long-term neuromuscular alterations during botulinum toxin treatment for chronic migraine
- Ladda ner fulltext (pdf) av Long-term neuromuscular alterations during botulinum toxin treatment for chronic migraine
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Lucid Dreaming: Not Just Awareness, but Agency
Ingår i Journal of Sleep Research, 2026
- DOI för Lucid Dreaming: Not Just Awareness, but Agency
- Ladda ner fulltext (pdf) av Lucid Dreaming: Not Just Awareness, but Agency
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Multiple Sclerosis: A Comprehensive Journey from Oligoclonal Bands to Cutting-Edge MRI Techniques
2026
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Novel Clinical Insights From a Swedish RFC1 Spectrum Disorder Cohort
Ingår i European Journal of Neurology, 2026
- DOI för Novel Clinical Insights From a Swedish RFC1 Spectrum Disorder Cohort
- Ladda ner fulltext (pdf) av Novel Clinical Insights From a Swedish RFC1 Spectrum Disorder Cohort
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Numinous-like symptoms in epilepsy and/or insular tumors: A hospital cohort study
Ingår i Epilepsy & Behavior, 2026
- DOI för Numinous-like symptoms in epilepsy and/or insular tumors: A hospital cohort study
- Ladda ner fulltext (pdf) av Numinous-like symptoms in epilepsy and/or insular tumors: A hospital cohort study
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Ingår i Neuroradiology, s. 1631-1639, 2026
- DOI för Pathological Signatures of White Matter Lesions in Multiple Sclerosis versus Stroke: A Synthetic MRI Study
- Ladda ner fulltext (pdf) av Pathological Signatures of White Matter Lesions in Multiple Sclerosis versus Stroke: A Synthetic MRI Study
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Ingår i Journal of Sleep Research, 2026
- DOI för Prevalence Rates of Frequent Dream Recall and Nightmares by Age, Gender and Sleep Duration in 16 Countries
- Ladda ner fulltext (pdf) av Prevalence Rates of Frequent Dream Recall and Nightmares by Age, Gender and Sleep Duration in 16 Countries
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Ingår i Radiography, 2026
- DOI för Radiation doses in ventriculoperitoneal shunt catheter imaging - Comparing traditional plain radiography with computed tomography and photon counting computed tomography.
- Ladda ner fulltext (pdf) av Radiation doses in ventriculoperitoneal shunt catheter imaging - Comparing traditional plain radiography with computed tomography and photon counting computed tomography.
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Ingår i Journal of Neuroimaging, 2026
- DOI för Rapid Estimation of Myelin for Diagnostic Imaging and Quantification of Therapy Responses in Multiple Sclerosis
- Ladda ner fulltext (pdf) av Rapid Estimation of Myelin for Diagnostic Imaging and Quantification of Therapy Responses in Multiple Sclerosis
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Ingår i Lancet Neurology, s. 550-559, 2026
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Standardized Mortality Ratio and Long-Term Stroke Incidence After PFO Closure: A Register Study
Ingår i JACC: Advances, 2026
- DOI för Standardized Mortality Ratio and Long-Term Stroke Incidence After PFO Closure: A Register Study
- Ladda ner fulltext (pdf) av Standardized Mortality Ratio and Long-Term Stroke Incidence After PFO Closure: A Register Study
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Ingår i Fluids and Barriers of the CNS, 2026
- DOI för Targeted CSF metabolomics and conformal prediction improve diagnostic accuracy of normal pressure hydrocephalus
- Ladda ner fulltext (pdf) av Targeted CSF metabolomics and conformal prediction improve diagnostic accuracy of normal pressure hydrocephalus
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Associations of PFAS and OH-PCBs with risk of multiple sclerosis onset and disability worsening
Ingår i Nature Communications, 2025
- DOI för Associations of PFAS and OH-PCBs with risk of multiple sclerosis onset and disability worsening
- Ladda ner fulltext (pdf) av Associations of PFAS and OH-PCBs with risk of multiple sclerosis onset and disability worsening
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Ingår i Fluids and Barriers of the CNS, 2025
- DOI för Blinded gait assessment in idiopathic normal pressure hydrocephalus: reliability and correlation with clinical and patient-reported outcomes
- Ladda ner fulltext (pdf) av Blinded gait assessment in idiopathic normal pressure hydrocephalus: reliability and correlation with clinical and patient-reported outcomes
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Brain health: Pathway to primary prevention of neurodegenerative disorders of environmental origin
Ingår i Journal of the Neurological Sciences, 2025
- DOI för Brain health: Pathway to primary prevention of neurodegenerative disorders of environmental origin
- Ladda ner fulltext (pdf) av Brain health: Pathway to primary prevention of neurodegenerative disorders of environmental origin
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Ingår i Brain, behavior, and immunity, s. 163-176, 2025
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Ingår i World Neurosurgery, 2025
- DOI för Chronic, Shunt-Dependent Hydrocephalus in Aneurysmal Subarachnoid Hemorrhage: Incidence, Risk Factors, Clinical Phenotypes, and Outcome
- Ladda ner fulltext (pdf) av Chronic, Shunt-Dependent Hydrocephalus in Aneurysmal Subarachnoid Hemorrhage: Incidence, Risk Factors, Clinical Phenotypes, and Outcome
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Ingår i Journal of the Neurological Sciences, 2025
- DOI för Climate change impacts the symptomology and healthcare of multiple sclerosis patients through fatigue and heat sensitivity: A systematic review
- Ladda ner fulltext (pdf) av Climate change impacts the symptomology and healthcare of multiple sclerosis patients through fatigue and heat sensitivity: A systematic review
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Climate-related challenges to brain health: A European perspective review
Ingår i Revue Neurologique, 2025
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Ingår i The Lancet, s. 43-51, 2025
- DOI för Collaboration on the optimal timing of anticoagulation after ischaemic stroke and atrial fibrillation: a systematic review and prospective individual participant data meta-analysis of randomised controlled trials (CATALYST)
- Ladda ner fulltext (pdf) av Collaboration on the optimal timing of anticoagulation after ischaemic stroke and atrial fibrillation: a systematic review and prospective individual participant data meta-analysis of randomised controlled trials (CATALYST)
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Decrease of excessive daytime sleepiness after shunt treatment for normal pressure hydrocephalus
Ingår i Journal of Sleep Research, 2025
- DOI för Decrease of excessive daytime sleepiness after shunt treatment for normal pressure hydrocephalus
- Ladda ner fulltext (pdf) av Decrease of excessive daytime sleepiness after shunt treatment for normal pressure hydrocephalus
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Ingår i Upsala Journal of Medical Sciences, 2025
- DOI för Enhancing Recruitment Using Teleconference and Commitment Contract (ERUTECC): a stepped wedge cluster randomised trial within the EFFECTS trial
- Ladda ner fulltext (pdf) av Enhancing Recruitment Using Teleconference and Commitment Contract (ERUTECC): a stepped wedge cluster randomised trial within the EFFECTS trial
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Ingår i International Journal of Stroke, s. 540-549, 2025
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Genetic Risk Factors for Poor Cognitive Outcome Following Brain Insult - A Systematic Review
Ingår i Brain and Behavior, 2025
- DOI för Genetic Risk Factors for Poor Cognitive Outcome Following Brain Insult - A Systematic Review
- Ladda ner fulltext (pdf) av Genetic Risk Factors for Poor Cognitive Outcome Following Brain Insult - A Systematic Review
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Healthcare Burden and Productivity Loss Due to Narcolepsy in Sweden
Ingår i Clocks & Sleep, 2025
- DOI för Healthcare Burden and Productivity Loss Due to Narcolepsy in Sweden
- Ladda ner fulltext (pdf) av Healthcare Burden and Productivity Loss Due to Narcolepsy in Sweden
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Ingår i Physiotherapy Theory and Practice, s. 763-771, 2025
- DOI för “I’m still the person I am. Not the body it has become.”: An active but challenging life with cervical dystonia
- Ladda ner fulltext (pdf) av “I’m still the person I am. Not the body it has become.”: An active but challenging life with cervical dystonia
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Ingår i Injury, 2025
- DOI för Injury recidivism in women with personality disorders reflects an increased risk for both natural and unnatural death
- Ladda ner fulltext (pdf) av Injury recidivism in women with personality disorders reflects an increased risk for both natural and unnatural death
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Ingår i European Journal of Neurology, 2025
- DOI för Levodopa-entacapone-carbidopa intestinal gel: Data from the Swedish national registry for Parkinson's disease
- Ladda ner fulltext (pdf) av Levodopa-entacapone-carbidopa intestinal gel: Data from the Swedish national registry for Parkinson's disease
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Ingår i Sleep Medicine, 2025
- DOI för Long COVID as a risk factor for hypersomnolence and fatigue: insights from the 2nd International Covid Sleep Study Collaboration (ICOSS-2)
- Ladda ner fulltext (pdf) av Long COVID as a risk factor for hypersomnolence and fatigue: insights from the 2nd International Covid Sleep Study Collaboration (ICOSS-2)
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Ingår i Journal of the American Heart Association, 2025
- DOI för Neuroglial Biomarkers for Risk Assessment of Ischemic Stroke and Other Cardiovascular Events in Patients with Atrial Fibrillation Not Receiving Oral Anticoagulation
- Ladda ner fulltext (pdf) av Neuroglial Biomarkers for Risk Assessment of Ischemic Stroke and Other Cardiovascular Events in Patients with Atrial Fibrillation Not Receiving Oral Anticoagulation
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Ingår i Neurology, 2025
- DOI för Nicotine, Alcohol Consumption, and Risk of Myasthenia Gravis Results From the Swedish Nationwide GEMG Study
- Ladda ner fulltext (pdf) av Nicotine, Alcohol Consumption, and Risk of Myasthenia Gravis Results From the Swedish Nationwide GEMG Study
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Patient experiences of narcolepsy and idiopathic hypersomnia in the Nordics: a patient journey map
Ingår i Journal of Sleep Research, 2025
- DOI för Patient experiences of narcolepsy and idiopathic hypersomnia in the Nordics: a patient journey map
- Ladda ner fulltext (pdf) av Patient experiences of narcolepsy and idiopathic hypersomnia in the Nordics: a patient journey map
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Ingår i Frontiers in Neurology, 2025
- DOI för Plasma cholinergic markers are associated with post-stroke walking recovery-revisiting the STROKEWALK study
- Ladda ner fulltext (pdf) av Plasma cholinergic markers are associated with post-stroke walking recovery-revisiting the STROKEWALK study
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Ingår i Journal of the Neurological Sciences, 2025
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Ingår i European Journal of Neurology, 2025
- DOI för Rituximab in New-Onset Generalized Myasthenia Gravis: Long-Term Follow-Up of the RINOMAX Clinical Trial
- Ladda ner fulltext (pdf) av Rituximab in New-Onset Generalized Myasthenia Gravis: Long-Term Follow-Up of the RINOMAX Clinical Trial
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Ingår i Journal of Sleep Research, 2025