Cancerfarmakologi och beräkningsmedicin

Ex vivo drug responses and molecular profiles of 597 pediatric acute lymphoblastic leukemia patients

Enblad, Anna Pia; Krali, Olga; Gezelius, Henrik; Lundmark, Anders et al.

Ingår i HemaSphere, 2025

• DOI för Ex vivo drug responses and molecular profiles of 597 pediatric acute lymphoblastic leukemia patients
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Second‐ and Third‐Line Salvage Chemotherapy Followed by Allogeneic Stem Cell Transplantation Leads to High Survival Rates in Primary Refractory AML—A Population‐Based Study

Liew‐Littorin, Markus; Deleskog‐Spångberg, Linn; Deneberg, Stefan; Janosi, Judit et al.

Ingår i European Journal of Haematology, s. 423-432, 2025

• DOI för Second‐ and Third‐Line Salvage Chemotherapy Followed by Allogeneic Stem Cell Transplantation Leads to High Survival Rates in Primary Refractory AML—A Population‐Based Study

Second‐ and Third‐Line Salvage Chemotherapy Followed by Allogeneic Stem Cell Transplantation Leads to High Survival Rates in Primary Refractory AML—A Population‐Based Study

Liew‐Littorin, Markus; Deleskog‐Spångberg, Linn; Deneberg, Stefan; Janosi, Judit et al.

Ingår i European Journal of Haematology, s. 423-432, 2025

• DOI för Second‐ and Third‐Line Salvage Chemotherapy Followed by Allogeneic Stem Cell Transplantation Leads to High Survival Rates in Primary Refractory AML—A Population‐Based Study

Molecular classification of microsatellite-instable colorectal cancers reveals distinct predictors of immunotherapy response

Lin, C.; Luo, T.; Wu, M.; Li, F. et al.

Ingår i ESMO GASTROINTESTINAL ONCOLOGY, 2025

• DOI för Molecular classification of microsatellite-instable colorectal cancers reveals distinct predictors of immunotherapy response
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Plasma Profiles of Neuroglial Injury Biomarkers after Ischemic Stroke

Sjölin, Karl; Röyter, Björn; Forgo, Bianka; Aulin, Julia et al.

Ingår i Translational Stroke Research, 2025

• DOI för Plasma Profiles of Neuroglial Injury Biomarkers after Ischemic Stroke

Conformal prediction enables disease course prediction and allows individualized diagnostic uncertainty in multiple sclerosis

Sreenivasan, Akshai Parakkal; Vaivade, Aina; Noui, Yassine; Emami Khoonsari, Payam et al.

Ingår i npj Digital Medicine, 2025

• DOI för Conformal prediction enables disease course prediction and allows individualized diagnostic uncertainty in multiple sclerosis
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Bronchoscopic intervention reduces dyspnea in severely symptomatic patients with central malignant airway obstruction

Svensson, Malin; Palm, Andreas; Westo, Nilla; Lindskog, Magnus

Ingår i Journal of Pain and Symptom Management, s. 38-45, 2025

• DOI för Bronchoscopic intervention reduces dyspnea in severely symptomatic patients with central malignant airway obstruction
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Exploratory study linking plasma proteomics to cardiotoxicity in Hodgkin lymphoma

Ulfstedt, Johan Mattsson; Risebro, Ragnhild; Freyhult, Eva; Christersson, Christina et al.

Ingår i Cardio-Oncology, 2025

• DOI för Exploratory study linking plasma proteomics to cardiotoxicity in Hodgkin lymphoma

Elevated levels of aquaporin-4-containing extracellular vesicles in cerebrospinal fluid of patients with bipolar disorder

Wetterberg, Lennart; Mobarrez, Fariborz; Nybom, Rolf; Wallen, Hakan et al.

Ingår i Upsala Journal of Medical Sciences, 2025

• DOI för Elevated levels of aquaporin-4-containing extracellular vesicles in cerebrospinal fluid of patients with bipolar disorder
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Oncological Outcome for 83 Consecutive Patients With Malignant Peripheral Nerve Sheath Tumors Treated at a Tertiary Referral Centre

Yeomans, Hannah V. M.; Lloyd, Kira C.; De Flon, Felix Haglund; Mansoori, Sharmineh et al.

Ingår i Cancer Reports, 2025

• DOI för Oncological Outcome for 83 Consecutive Patients With Malignant Peripheral Nerve Sheath Tumors Treated at a Tertiary Referral Centre
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Exhaustive in vitro evaluation of the 9-drug cocktail CUSP9 for treatment of glioblastoma

Chantzi, Efthymia; Hammerling, Ulf; Gustafsson, Mats G.

Ingår i Computers in Biology and Medicine, 2024

• DOI för Exhaustive in vitro evaluation of the 9-drug cocktail CUSP9 for treatment of glioblastoma
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Comparison of high-throughput single-cell RNA-seq methods for ex vivo drug screening

Gezelius, Henrik; Enblad, Anna Pia; Lundmark, Anders; Åberg, Martin et al.

Ingår i NAR Genomics and Bioinformatics, 2024

• DOI för Comparison of high-throughput single-cell RNA-seq methods for ex vivo drug screening
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Tumor-specific migration routes of xenotransplanted human glioblastoma cells in mouse brain

Gupta, Rajesh Kumar; Niklasson, Mia; Bergström, Tobias; Segerman, Anna et al.

Ingår i Scientific Reports, 2024

• DOI för Tumor-specific migration routes of xenotransplanted human glioblastoma cells in mouse brain
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Pharmacokinetics and Metabolism of Melflufen, an Alkylating Peptide-Drug Conjugate, in Patients with Relapsed Refractory Multiple Myeloma

Huledal, Gunilla; Ruiz-Garcia, Ana; Kawakatsu, Sonoko; Wang, Xiaoning et al.

Ingår i Journal of clinical pharmacology, s. 240-252, 2024

• DOI för Pharmacokinetics and Metabolism of Melflufen, an Alkylating Peptide-Drug Conjugate, in Patients with Relapsed Refractory Multiple Myeloma

Enrichment of thawed boar spermatozoa with an intact membrane using Magnetic Activated Cell Sorting

Johannisson, Anders; Morrell, Jane M.; Wallgren, Margareta

Ingår i Animal Reproduction Science, 2024

• DOI för Enrichment of thawed boar spermatozoa with an intact membrane using Magnetic Activated Cell Sorting
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Fluid therapy is associated with lower care quality and higher symptom burden during last days of life of patients with cancer: - a population-based register study

Lindskog, Magnus; Mogensen, Hanna; Tavelin, Bjoern; Eknert, Johanna et al.

Ingår i BMC Palliative Care, 2024

• DOI för Fluid therapy is associated with lower care quality and higher symptom burden during last days of life of patients with cancer: - a population-based register study
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OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids

Mickols, Evgeniya; Meyer, Alina; Handin, Niklas; Stüwe, Malin et al.

Ingår i Scientific Reports, 2024

• DOI för OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids
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Exploratory insights from the immuno-oncology hollow fiber assay: A pilot approach bridging In Vitro and In Vivo models

Selvin, Tove; Berglund, Malin; Akerstrom, Anders; Zia, Marco et al.

Ingår i SLAS TECHNOLOGY, 2024

• DOI för Exploratory insights from the immuno-oncology hollow fiber assay: A pilot approach bridging In Vitro and In Vivo models
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Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment

Selvin, Tove; Berglund, Malin; Lenhammar, Lena; Lindskog, Magnus et al.

Ingår i BMC Pharmacology & Toxicology, 2024

• DOI för Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment
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Assessment in vitro of interactions between anti-cancer drugs and noncancer drugs commonly used by cancer patients

Andersson, Claes; Ye, Jiawei; Blom, Kristin; Fryknäs, Mårten et al.

Ingår i Anti-Cancer Drugs, s. 92-102, 2023

• DOI för Assessment in vitro of interactions between anti-cancer drugs and noncancer drugs commonly used by cancer patients
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Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma

Calitz, Carlemi; Rosenquist, Jenny; Degerstedt, Oliver; Khaled, Jaafar et al.

Ingår i Scientific Reports, 2023

• DOI för Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma
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The value of post-operative chemotherapy after chemoradiotherapy in patients with high-risk locally advanced rectal cancerdresults from the RAPIDO trial

Dijkstra, E. A.; Zwart, W. H.; Nilsson, P. J.; Putter, H. et al.

Ingår i ESMO Open, 2023

• DOI för The value of post-operative chemotherapy after chemoradiotherapy in patients with high-risk locally advanced rectal cancerdresults from the RAPIDO trial

Somatic Exonic Deletions in RUNX1 Constitutes a Novel Recurrent Genomic Abnormality in Acute Myeloid Leukemia

Eriksson, Anna; Engvall, Marie; Mathot, Lucy; Österroos, Albin et al.

Ingår i Clinical Cancer Research, s. 2826-2834, 2023

• DOI för Somatic Exonic Deletions in RUNX1 Constitutes a Novel Recurrent Genomic Abnormality in Acute Myeloid Leukemia

Disease phenotype prediction in multiple sclerosis

Herman, Stephanie; Arvidsson McShane, Staffan; Zhukovsky, Christina; Emami, Payam et al.

Ingår i iScience, 2023

• DOI för Disease phenotype prediction in multiple sclerosis
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Aminopeptidases in Cancer, Biology and Prospects for Pharmacological Intervention

Holstein, Sarah A.; Heckman, Caroline A.; Davies, Faith E.; Morgan, Gareth J. et al.

Ingår i Current Cancer Drug Targets, s. 25-46, 2023

• DOI för Aminopeptidases in Cancer, Biology and Prospects for Pharmacological Intervention

Extracellular vesicles opsonized by monomeric C-reactive protein (CRP) are accessible as autoantigens in patients with systemic lupus erythematosus and associate with autoantibodies against CRP

Karlsson, Jesper; Wettero, Jonas; Potempa, Lawrence A.; Fernandez-Botran, Rafael et al.

Ingår i Journal of Autoimmunity, 2023

• DOI för Extracellular vesicles opsonized by monomeric C-reactive protein (CRP) are accessible as autoantigens in patients with systemic lupus erythematosus and associate with autoantibodies against CRP
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Electronic Cigarette Vaping with Nicotine Causes Increased Thrombogenicity and Impaired Microvascular Function in Healthy Volunteers: A Randomised Clinical Trial

Lyytinen, Gustaf; Brynedal, Amelie; Anesater, Erik; Antoniewicz, Lukasz et al.

Ingår i Cardiovascular Toxicology, s. 255-264, 2023

• DOI för Electronic Cigarette Vaping with Nicotine Causes Increased Thrombogenicity and Impaired Microvascular Function in Healthy Volunteers: A Randomised Clinical Trial
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Evaluation of domestic animal sperm head morphology via flow cytometric DNA labelling and pulse shape analysis using bull and stallion spermatozoa as model species

Nagy, Szabolcs; Kovacs, Barnabas; Johannisson, Anders

Ingår i Reproduction in domestic animals, s. 1569-1575, 2023

• DOI för Evaluation of domestic animal sperm head morphology via flow cytometric DNA labelling and pulse shape analysis using bull and stallion spermatozoa as model species
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Managing leukemia patients via liquid biopsy and super rolling circle amplification (superRCA)

Robelius, Anna; Chen, Lei; Amini, Rose-Marie; Cavelier, Lucia et al.

Ingår i Journal of Internal Medicine, s. 228-237, 2023

• DOI för Managing leukemia patients via liquid biopsy and super rolling circle amplification (superRCA)

Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients

Sarén, Tina; Ramachandran, Mohanraj; Gammelgård, Gustav; Lövgren, Tanja et al.

Ingår i Clinical Cancer Research, s. 4139-4152, 2023

• DOI för Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients
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Preclinical tumor-immune modeling: For the identification of immunomodulatory drugs

Selvin, Tove

2023

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Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death

Selvin, Tove; Berglund, Malin; Lenhammar, Lena; Jarvius, Malin et al.

Ingår i BMC Cancer, 2023

• DOI för Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death
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Ex vivo assessment of cancer drug sensitivity in epithelial ovarian cancer and its association with histopathological type, treatment history and clinical outcome

Bjersand, Kathrine; Blom, Kristin; Sundström Poromaa, Inger; Stålberg, Karin et al.

Ingår i International Journal of Oncology, 2022

• DOI för Ex vivo assessment of cancer drug sensitivity in epithelial ovarian cancer and its association with histopathological type, treatment history and clinical outcome
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Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Bonagas, Nadilly; Gustafsson, Nina M. S.; Henriksson, Martin; Marttila, Petra et al.

Ingår i Nature Cancer, s. 156, 2022

• DOI för Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
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Vilande cancerceller: Tredimensionella cellmodeller för utvärdering av nya cancerläkemedel

Ek, Frida

2022

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Immune-Proteome Profiling in Classical Hodgkin Lymphoma Tumor Diagnostic Tissue

Gholiha, Alex R.; Hollander, Peter; Löf, Liza; Larsson, Anders et al.

Ingår i Cancers, 2022

• DOI för Immune-Proteome Profiling in Classical Hodgkin Lymphoma Tumor Diagnostic Tissue
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Lysophophatidylcholine 16:0 mediates chronic joint pain associated to rheumatic diseases through acid-sensing ion channel 3

Jacquot, F.; Khoury, S.; Labrum, B.; Delanoe, K. et al.

Ingår i Pain, s. 1999-2013, 2022

• DOI för Lysophophatidylcholine 16:0 mediates chronic joint pain associated to rheumatic diseases through acid-sensing ion channel 3
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Selective radiosensitization by nitazoxanide of quiescent clonogenic colon cancer tumour cells

Karlsson, Henning; Fryknäs, Mårten; Senkowski, Wojciech; Larsson, Rolf et al.

Ingår i Oncology Letters, 2022

• DOI för Selective radiosensitization by nitazoxanide of quiescent clonogenic colon cancer tumour cells
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Ilixadencel, a Cell-based Immune Primer, plus Sunitinib Versus Sunitinib Alone in Metastatic Renal Cell Carcinoma: A Randomized Phase 2 Study

Lindskog, Magnus; Laurell, Anna; Kjellman, Anders; Melichar, Bohuslav et al.

Ingår i European Urology Open Science, s. 38-45, 2022

• DOI för Ilixadencel, a Cell-based Immune Primer, plus Sunitinib Versus Sunitinib Alone in Metastatic Renal Cell Carcinoma: A Randomized Phase 2 Study
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Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival

Lu, Xi; Maturi, Naga Prathyusha; Jarvius, Malin; Yildirim, Irem et al.

Ingår i Nature Communications, 2022

• DOI för Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival
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Sorafenib and nitazoxanide disrupt mitochondrial function and inhibit regrowth capacity in three-dimensional models of hepatocellular and colorectal carcinoma

Nyberg, Frida; Blom, Kristin; Selvin, Tove; Rudfeldt, Jakob et al.

Ingår i Scientific Reports, 2022

• DOI för Sorafenib and nitazoxanide disrupt mitochondrial function and inhibit regrowth capacity in three-dimensional models of hepatocellular and colorectal carcinoma
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Surgical waiting times and all-cause mortality in patients with non-metastatic renal cell carcinoma

Rosenblad, Andreas; Sundqvist, Pernilla; Harmenberg, Ulrika; Hellström, Mikael et al.

Ingår i Scandinavian journal of urology, s. 383-390, 2022

• DOI för Surgical waiting times and all-cause mortality in patients with non-metastatic renal cell carcinoma
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Plasma protein biomarker profiling reveals major differences between acute leukaemia, lymphoma patients and controls

Sabaa, Amal Abu; Shen, Qiujin; Lennmyr, Emma; Enblad, Anna Pia et al.

Ingår i New Biotechnology, s. 21-29, 2022

• DOI för Plasma protein biomarker profiling reveals major differences between acute leukaemia, lymphoma patients and controls
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Single-cell transcriptional pharmacodynamics of trifluridine in a tumor-immune model

Selvin, Tove; Fasterius, Erik; Jarvius, Malin; Fryknäs, Mårten et al.

Ingår i Scientific Reports, 2022

• DOI för Single-cell transcriptional pharmacodynamics of trifluridine in a tumor-immune model
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Metabolomics: The Stethoscope for the Twenty-First Century

Ashrafian, Hutan; Sounderajah, Viknesh; Glen, Robert; Ebbels, Timothy et al.

Ingår i Medical principles and practice, s. 301-310, 2021

• DOI för Metabolomics: The Stethoscope for the Twenty-First Century
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Multi‐cohort profiling reveals elevated CSF levels of brain‐enriched proteins in Alzheimer’s disease

Bergström, Sofia; Remnestål, Julia; Yousef, Jamil; Olofsson, Jennie et al.

Ingår i Annals of Clinical and Translational Neurology, s. 1456-1470, 2021

• DOI för Multi‐cohort profiling reveals elevated CSF levels of brain‐enriched proteins in Alzheimer’s disease
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Different Inflammatory Signatures in Alzheimer's Disease and Frontotemporal Dementia Cerebrospinal Fluid

Boström, Gustaf; Freyhult, Eva; Virhammar, Johan; Alcolea, Daniel et al.

Ingår i Journal of Alzheimer's Disease, s. 629-640, 2021

• DOI för Different Inflammatory Signatures in Alzheimer's Disease and Frontotemporal Dementia Cerebrospinal Fluid
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Melphalan flufenamide inhibits osteoclastogenesis by suppressing proliferation of monocytes

Byrgazov, Konstantin; Lind, Thomas; Rasmusson, Annica J.; Andersson, Claes et al.

Ingår i Bone Reports, 2021

• DOI för Melphalan flufenamide inhibits osteoclastogenesis by suppressing proliferation of monocytes

Increased levels of plasma cytokines and correlations to organ failure and 30-day mortality in critically ill Covid-19 patients

Bülow Anderberg, Sara; Luther, Tomas; Berglund, Malin; Larsson, Rolf et al.

Ingår i Cytokine, 2021

• DOI för Increased levels of plasma cytokines and correlations to organ failure and 30-day mortality in critically ill Covid-19 patients
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Conditions for maintenance of hepatocyte differentiation and function in 3D cultures

Handin, Niklas; Mickols, Evgeniya; Ölander, Magnus; Rudfeldt, Jakob et al.

Ingår i iScience, 2021

• DOI för Conditions for maintenance of hepatocyte differentiation and function in 3D cultures
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