Hematologi

Inom forskargruppen bedrivs klinisk forskning inom olika former av leukemier och myeloproliferativa sjukdomar men även rörande anemibehandling och omvårdnad. Genom preklinisk läkemedelsutveckling, deltagande i ett stort antal kliniska prövningar samt genom studier med utgångspunkt i våra populationsbaserade cancerregister försöker vi utveckla nya behandlingsmetoder och en bättre omvårdnad för drabbade patienter.
Hematologin omfattar såväl benigna som maligna tillstånd. Bland de benigna märks olika typer av cytopenier, både medfödda och förvärvade, som anemier, neutropenier och trombocytopenier, rubbningar i järnmetabolismen med flera. De maligna blodsjukdomarna utgör en stor, heterogen grupp av cancersjukdomar som svarar för ca 7 % av årliga nya cancerfall i Sverige.
Hematologiska maligniteter orsakas för det mesta av en okontrollerad tillväxt eller delning av blodcellerna, och vanligen är det omogna stamceller som förlorat sin tillväxtkontroll. Sådan kontrollförlust kan ge upphov till både akuta och kroniska leukemier med överproduktion av vita blodkroppar, men också till s.k. myeloproliferativa sjukdomar med överproduktion av röda blodkroppar och/eller blodplättar.
Fokus för forskningen
Forskningen bedrivs av ett antal mindre grupper, var och en formerad utifrån specifik kompetens kring enskilda viktiga sjukdomar inom hematologin. Vårt fokus är nu på
- Utveckling och testning av nya läkemedel och terapier för hematologiska maligniteter; akut myeloisk leukemi, akut lymfatisk leukemi, myelodysplastiskt syndrom, kronisk myeloisk leukemi, kronisk lymfatisk leukemi samt multipelt myelom.
- Studier med utgångspunkt från våra populationsbaserade kvalitetsregister inom blodcancerområdet.
- Translationella studier i anslutning till det regionala biobanksprojektet U-CAN
- Studier kring myeloproliferativa sjukdomar, canceranemi och omvårdnad.
En viktig del i verksamheten är också deltagande i nationella och internationella samarbeten för att initiera stora kliniska prövningar och för att utarbeta riktlinjer för behandling.
Gruppmedlemmar
Publikationer
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Ingår i Bone Marrow Transplantation, s. 326-332, 2026
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Ingår i Thrombosis Research, 2026
- DOI för Reperfusion treatment strategies in acute pulmonary embolism: Study protocol for a multicenter prospective observational study in the Nordic countries (PE-NORDIC)
- Ladda ner fulltext (pdf) av Reperfusion treatment strategies in acute pulmonary embolism: Study protocol for a multicenter prospective observational study in the Nordic countries (PE-NORDIC)
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IL-33 enhances responsiveness and mast cell mediator release in isolated human small airways
Ingår i Journal of Allergy and Clinical Immunology, s. 1286-1294, 2026
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Ingår i The Journal of American Academy of Dermatology, 2026
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Ingår i Transplantation and Cellular Therapy, s. 1950-1950000000000000, 2026
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Ingår i Transplantation and Cellular Therapy, s. 966-966, 2026
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Expression of CD25 in human lung mast cells and its regulation by IL-33
Ingår i Journal of Allergy and Clinical Immunology, s. 1442-1449, 2026
- DOI för Expression of CD25 in human lung mast cells and its regulation by IL-33
- Ladda ner fulltext (pdf) av Expression of CD25 in human lung mast cells and its regulation by IL-33
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Ingår i Transplantation and Cellular Therapy, s. 2130-213000000000, 2026
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Ingår i Experimental Hematology & Oncology, 2026
- DOI för Subtype-specific outcome after allogeneic hematopoietic cell transplantation in advanced systemic mastocytosis: a registry study of the European competence network on mastocytosis
- Ladda ner fulltext (pdf) av Subtype-specific outcome after allogeneic hematopoietic cell transplantation in advanced systemic mastocytosis: a registry study of the European competence network on mastocytosis
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Ingår i Transplantation and Cellular Therapy, 2026
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Ingår i Journal of Allergy and Clinical Immunology, 2026
- DOI för Hereditary alpha-tryptasemia demonstrates relative basophil enrichment without signs of cellular hyperreactivity
- Ladda ner fulltext (pdf) av Hereditary alpha-tryptasemia demonstrates relative basophil enrichment without signs of cellular hyperreactivity
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Targeting IMPDH to inhibit SAMHD1 in KMT2A-rearranged leukaemia
Ingår i Cell Cycle, s. 1-19, 2026
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Ingår i British Journal of Haematology, s. 514-523, 2026
- DOI för Comorbidities and mutations including single- and multihit TET2 mutations in relation to outcome in chronic myelomonocytic leukaemia: a population-based study
- Ladda ner fulltext (pdf) av Comorbidities and mutations including single- and multihit TET2 mutations in relation to outcome in chronic myelomonocytic leukaemia: a population-based study
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Development of a prognostic scoring system for chronic myeloid leukemia in blast phase
Ingår i Leukemia, s. 751-758, 2026
- DOI för Development of a prognostic scoring system for chronic myeloid leukemia in blast phase
- Ladda ner fulltext (pdf) av Development of a prognostic scoring system for chronic myeloid leukemia in blast phase
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Ingår i Scandinavian Journal of Gastroenterology, s. 160-169, 2026
- DOI för Investigating instruments for evaluation of gastrointestinal burdens in patients with systemic mastocytosis: an exploratory multimethod study
- Ladda ner fulltext (pdf) av Investigating instruments for evaluation of gastrointestinal burdens in patients with systemic mastocytosis: an exploratory multimethod study
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Ingår i HemaSphere, 2026
- DOI för Deep cytomorphology identifies erythroid skewing and monocytic morphology to predict TKI sensitivity in CML patients
- Ladda ner fulltext (pdf) av Deep cytomorphology identifies erythroid skewing and monocytic morphology to predict TKI sensitivity in CML patients
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Exploratory study linking plasma proteomics to cardiotoxicity in Hodgkin lymphoma
Ingår i Cardio-Oncology, 2026
- DOI för Exploratory study linking plasma proteomics to cardiotoxicity in Hodgkin lymphoma
- Ladda ner fulltext (pdf) av Exploratory study linking plasma proteomics to cardiotoxicity in Hodgkin lymphoma
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Landscape of circular RNAs in acute myeloid leukemia and their clinical significance
Ingår i npj Precision Oncology, 2026
- DOI för Landscape of circular RNAs in acute myeloid leukemia and their clinical significance
- Ladda ner fulltext (pdf) av Landscape of circular RNAs in acute myeloid leukemia and their clinical significance
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Ingår i Cancers, 2026
- DOI för The Effect of Smoking and Pre-Allogeneic Hematopoietic Cell Transplant Pulmonary Comorbidity on the Incidence of Lung Graft-Versus-Host Disease and Post-Transplant Outcomes
- Ladda ner fulltext (pdf) av The Effect of Smoking and Pre-Allogeneic Hematopoietic Cell Transplant Pulmonary Comorbidity on the Incidence of Lung Graft-Versus-Host Disease and Post-Transplant Outcomes
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Ingår i eJHaem, 2026
- DOI för Adding Bortezomib and Bendamustine to High-Dose Melphalan in Autologous Haematopoietic Stem Cell Transplantation for Relapsed Multiple Myeloma-A Single Centre Retrospective Study
- Ladda ner fulltext (pdf) av Adding Bortezomib and Bendamustine to High-Dose Melphalan in Autologous Haematopoietic Stem Cell Transplantation for Relapsed Multiple Myeloma-A Single Centre Retrospective Study
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Ingår i npj Precision Oncology, 2026
- DOI för Midostaurin response in AML is shaped by a progenitor-like cell state selectively targeted by SMAC mimetics
- Ladda ner fulltext (pdf) av Midostaurin response in AML is shaped by a progenitor-like cell state selectively targeted by SMAC mimetics
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Ingår i Environment International, 2026
- DOI för An exploratory study of environmental and nutritional determinants of early-stage clonal hematopoiesis in the elderly
- Ladda ner fulltext (pdf) av An exploratory study of environmental and nutritional determinants of early-stage clonal hematopoiesis in the elderly
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Ingår i European Journal of Haematology, s. 251-259, 2025
- DOI för Impact of Conditioning Intensity on Survival in Adult Patients (< 65 Years) With Acute Myeloid Leukemia Receiving Antithymocyte Globulin and Post-Transplantation Cyclophosphamide Based GVHD Prophylaxis
- Ladda ner fulltext (pdf) av Impact of Conditioning Intensity on Survival in Adult Patients (< 65 Years) With Acute Myeloid Leukemia Receiving Antithymocyte Globulin and Post-Transplantation Cyclophosphamide Based GVHD Prophylaxis
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Ingår i Transplantation and Cellular Therapy, s. 6950-695000000000000, 2025
- DOI för Association of Cyclosporine Exposure Post-Allogeneic Hematopoietic Cell Transplant With Graft Failure and Relapse Risk in Hematological Malignancies
- Ladda ner fulltext (pdf) av Association of Cyclosporine Exposure Post-Allogeneic Hematopoietic Cell Transplant With Graft Failure and Relapse Risk in Hematological Malignancies
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Ingår i Transplantation direct, 2025
- DOI för Impact of Granulocyte Colony-Stimulating Factor (G-CSF) on Clinical Outcomes in Allogeneic Hematopoietic Cell Transplantation: Does Speeding Up Neutrophil Engraftment Make a Difference?
- Ladda ner fulltext (pdf) av Impact of Granulocyte Colony-Stimulating Factor (G-CSF) on Clinical Outcomes in Allogeneic Hematopoietic Cell Transplantation: Does Speeding Up Neutrophil Engraftment Make a Difference?
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Ingår i British Journal of Haematology, s. 2507-2516, 2025
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Ingår i Bone Marrow Transplantation, s. 1062-1064, 2025
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Ingår i Acta Dermato-Venereologica, 2025
- DOI för Evaluating Melanoma Risk in Adult Mastocytosis: Potential Impact of Detection Bias - A Registry-based Study (Sweden)
- Ladda ner fulltext (pdf) av Evaluating Melanoma Risk in Adult Mastocytosis: Potential Impact of Detection Bias - A Registry-based Study (Sweden)
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Ingår i The Journal of American Academy of Dermatology, s. 835-837, 2025
- DOI för Increased risk of skin cancer in mastocytosis: A large-scale retrospective cohort study of over 20,000 patients
- Ladda ner fulltext (pdf) av Increased risk of skin cancer in mastocytosis: A large-scale retrospective cohort study of over 20,000 patients
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Brain Networks Differ According to Levels of Interference in Spatiotemporal Processing
Ingår i Hippocampus, 2025
- DOI för Brain Networks Differ According to Levels of Interference in Spatiotemporal Processing
- Ladda ner fulltext (pdf) av Brain Networks Differ According to Levels of Interference in Spatiotemporal Processing
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Ingår i Cancer Gene Therapy, s. 1191-1205, 2025
- DOI för MALNC: a new mutant NPM1/IDH2R140 and PML-RARA-associated lncRNA with impact on AML cell proliferation, maturation and drug response
- Ladda ner fulltext (pdf) av MALNC: a new mutant NPM1/IDH2R140 and PML-RARA-associated lncRNA with impact on AML cell proliferation, maturation and drug response
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Ingår i Blood Advances, s. 660-669, 2025
- DOI för PTCy-based graft-versus-host disease prophylaxis for matched sibling donor allogeneic hematopoietic cell transplantation
- Ladda ner fulltext (pdf) av PTCy-based graft-versus-host disease prophylaxis for matched sibling donor allogeneic hematopoietic cell transplantation
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Ingår i Transplantation and Cellular Therapy, s. 9160-91600000000000, 2025
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Ingår i Haematologica, s. 179-182, 2025
- DOI för Respiratory syncytial virus and other vaccine-preventable infections in multiple myeloma: A population-based study on 8,672 myeloma patients diagnosed 2008-2021 from the Swedish Myeloma Registry
- Ladda ner fulltext (pdf) av Respiratory syncytial virus and other vaccine-preventable infections in multiple myeloma: A population-based study on 8,672 myeloma patients diagnosed 2008-2021 from the Swedish Myeloma Registry
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Ingår i International Journal of Circumpolar Health, 2025
- DOI för The meaning of cold bathing in middle aged and elderly people in Sweden: - a phenomenological hermeneutic study
- Ladda ner fulltext (pdf) av The meaning of cold bathing in middle aged and elderly people in Sweden: - a phenomenological hermeneutic study
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Ingår i Bone Marrow Transplantation, s. 1628-1634, 2025
- DOI för BEAM/ATG or cyclophosphamide/ATG as conditioning regimen in autologous haemopoietic stem cell transplantation for multiple sclerosis: a retrospective analysis of the EBMT autoimmune diseases working party
- Ladda ner fulltext (pdf) av BEAM/ATG or cyclophosphamide/ATG as conditioning regimen in autologous haemopoietic stem cell transplantation for multiple sclerosis: a retrospective analysis of the EBMT autoimmune diseases working party
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Ingår i Blood, s. 3139-3152, 2025
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Ingår i BMJ Open Gastroenterology, 2025
- DOI för Health-related quality of life in patients with liver cirrhosis following adjunctive nurse-based care versus standard medical care: a pragmatic, multicentre, randomised controlled study
- Ladda ner fulltext (pdf) av Health-related quality of life in patients with liver cirrhosis following adjunctive nurse-based care versus standard medical care: a pragmatic, multicentre, randomised controlled study
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Ingår i Journal of Allergy and Clinical Immunology, s. 1669-1678, 2025
- DOI för IgE-activated human lung mast cells preferentially release prostaglandin D2 , thromboxane A2 , and cysteinyl-leukotrienes
- Ladda ner fulltext (pdf) av IgE-activated human lung mast cells preferentially release prostaglandin D2 , thromboxane A2 , and cysteinyl-leukotrienes
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Ingår i Journal of clinical apheresis, 2025
- DOI för Hematopoietic Stem Cell Donors' Experiences of Information and Side‐Effects During the First Year After Donation—A Swedish National Study
- Ladda ner fulltext (pdf) av Hematopoietic Stem Cell Donors' Experiences of Information and Side‐Effects During the First Year After Donation—A Swedish National Study
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Ingår i Haematologica, s. 1774-1785, 2025
- DOI för Revaccination with pneumococcal conjugate vaccine five years after primary immunization improves immunity in patients with chronic lymphocytic leukemia
- Ladda ner fulltext (pdf) av Revaccination with pneumococcal conjugate vaccine five years after primary immunization improves immunity in patients with chronic lymphocytic leukemia
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Income and education affect prognosis and treatment in symptomatic myeloma
Ingår i Annals of Hematology, s. 565-572, 2025
- DOI för Income and education affect prognosis and treatment in symptomatic myeloma
- Ladda ner fulltext (pdf) av Income and education affect prognosis and treatment in symptomatic myeloma
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Ingår i Physiological Reports, 2025
- DOI för Regular postexercise sauna bathing does not improve heart rate variability: A multi-arm randomized controlled trial
- Ladda ner fulltext (pdf) av Regular postexercise sauna bathing does not improve heart rate variability: A multi-arm randomized controlled trial
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Ingår i International Journal of Circumpolar Health, 2025
- DOI för Women's perceptions of sauna bathing and its impact on health and well-being: insights from a cross-sectional study
- Ladda ner fulltext (pdf) av Women's perceptions of sauna bathing and its impact on health and well-being: insights from a cross-sectional study
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Ingår i eJHaem, 2025
- DOI för High Prevalence of Psychological Symptoms, Sexual Dysfunction, and Prolonged Medical Leave Two Years After Acute Leukemia Diagnosis-Patient Reported Outcome in Sweden
- Ladda ner fulltext (pdf) av High Prevalence of Psychological Symptoms, Sexual Dysfunction, and Prolonged Medical Leave Two Years After Acute Leukemia Diagnosis-Patient Reported Outcome in Sweden
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Ingår i European Journal of Haematology, s. 423-432, 2025
- DOI för Second‐ and Third‐Line Salvage Chemotherapy Followed by Allogeneic Stem Cell Transplantation Leads to High Survival Rates in Primary Refractory AML: A Population‐Based Study
- Ladda ner fulltext (pdf) av Second‐ and Third‐Line Salvage Chemotherapy Followed by Allogeneic Stem Cell Transplantation Leads to High Survival Rates in Primary Refractory AML: A Population‐Based Study
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Ingår i British Journal of Haematology, s. 2462-2474, 2025
- DOI för Addition of hydroxyurea (hydroxycarbamide) enhances the efficacy of fludarabine/cytarabine‐based salvage regimens against acute myeloid leukaemia
- Ladda ner fulltext (pdf) av Addition of hydroxyurea (hydroxycarbamide) enhances the efficacy of fludarabine/cytarabine‐based salvage regimens against acute myeloid leukaemia
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Ingår i Biomarker research, s. 67, 2025
- DOI för The overlooked trio: sleep duration, sampling time and physical exercise alter levels of olink-assessed blood biomarkers of cardiovascular risk.
- Ladda ner fulltext (pdf) av The overlooked trio: sleep duration, sampling time and physical exercise alter levels of olink-assessed blood biomarkers of cardiovascular risk.
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Ingår i Multiple Sclerosis Journal, s. 455-463, 2025
- DOI för Patient-reported outcomes of quality of life before and after autologous hematopoietic stem cell transplantation for multiple sclerosis
- Ladda ner fulltext (pdf) av Patient-reported outcomes of quality of life before and after autologous hematopoietic stem cell transplantation for multiple sclerosis
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Exploring the impact of opioid use on outcomes in allogeneic hematopoietic stem cell transplantation
Ingår i PLOS ONE, 2025
- DOI för Exploring the impact of opioid use on outcomes in allogeneic hematopoietic stem cell transplantation
- Ladda ner fulltext (pdf) av Exploring the impact of opioid use on outcomes in allogeneic hematopoietic stem cell transplantation