Hematologi

Inom forskargruppen bedrivs klinisk forskning inom olika former av leukemier och myeloproliferativa sjukdomar men även rörande anemibehandling och omvårdnad. Genom preklinisk läkemedelsutveckling, deltagande i ett stort antal kliniska prövningar samt genom studier med utgångspunkt i våra populationsbaserade cancerregister försöker vi utveckla nya behandlingsmetoder och en bättre omvårdnad för drabbade patienter.
Hematologin omfattar såväl benigna som maligna tillstånd. Bland de benigna märks olika typer av cytopenier, både medfödda och förvärvade, som anemier, neutropenier och trombocytopenier, rubbningar i järnmetabolismen med flera. De maligna blodsjukdomarna utgör en stor, heterogen grupp av cancersjukdomar som svarar för ca 7 % av årliga nya cancerfall i Sverige.
Hematologiska maligniteter orsakas för det mesta av en okontrollerad tillväxt eller delning av blodcellerna, och vanligen är det omogna stamceller som förlorat sin tillväxtkontroll. Sådan kontrollförlust kan ge upphov till både akuta och kroniska leukemier med överproduktion av vita blodkroppar, men också till s.k. myeloproliferativa sjukdomar med överproduktion av röda blodkroppar och/eller blodplättar.
Fokus för forskningen
Forskningen bedrivs av ett antal mindre grupper, var och en formerad utifrån specifik kompetens kring enskilda viktiga sjukdomar inom hematologin. Vårt fokus är nu på
- Utveckling och testning av nya läkemedel och terapier för hematologiska maligniteter; akut myeloisk leukemi, akut lymfatisk leukemi, myelodysplastiskt syndrom, kronisk myeloisk leukemi, kronisk lymfatisk leukemi samt multipelt myelom.
- Studier med utgångspunkt från våra populationsbaserade kvalitetsregister inom blodcancerområdet.
- Translationella studier i anslutning till det regionala biobanksprojektet U-CAN
- Studier kring myeloproliferativa sjukdomar, canceranemi och omvårdnad.
En viktig del i verksamheten är också deltagande i nationella och internationella samarbeten för att initiera stora kliniska prövningar och för att utarbeta riktlinjer för behandling.
Gruppmedlemmar
Publikationer
Ingår i European Journal of Haematology, s. 251-259, 2025
- DOI för Impact of Conditioning Intensity on Survival in Adult Patients (< 65 Years) With Acute Myeloid Leukemia Receiving Antithymocyte Globulin and Post-Transplantation Cyclophosphamide Based GVHD Prophylaxis
- Ladda ner fulltext (pdf) av Impact of Conditioning Intensity on Survival in Adult Patients (< 65 Years) With Acute Myeloid Leukemia Receiving Antithymocyte Globulin and Post-Transplantation Cyclophosphamide Based GVHD Prophylaxis
Ingår i Transplantation direct, 2025
- DOI för Impact of Granulocyte Colony-Stimulating Factor (G-CSF) on Clinical Outcomes in Allogeneic Hematopoietic Cell Transplantation: Does Speeding Up Neutrophil Engraftment Make a Difference?
- Ladda ner fulltext (pdf) av Impact of Granulocyte Colony-Stimulating Factor (G-CSF) on Clinical Outcomes in Allogeneic Hematopoietic Cell Transplantation: Does Speeding Up Neutrophil Engraftment Make a Difference?
Ingår i British Journal of Haematology, 2025
- DOI för Can we move beyond myeloablative conditioning (MAC)?: A comparison of MAC versus reduced intensity conditioning (RIC) in patients aged younger than 65 years undergoing allogeneic haematopoietic cell transplantation using ATG-PTCy-CSA for GVHD prophylaxis
- Ladda ner fulltext (pdf) av Can we move beyond myeloablative conditioning (MAC)?: A comparison of MAC versus reduced intensity conditioning (RIC) in patients aged younger than 65 years undergoing allogeneic haematopoietic cell transplantation using ATG-PTCy-CSA for GVHD prophylaxis
Ingår i Bone Marrow Transplantation, s. 1062-1064, 2025
Ingår i Acta Dermato-Venereologica, 2025
- DOI för Evaluating Melanoma Risk in Adult Mastocytosis: Potential Impact of Detection Bias - A Registry-based Study (Sweden)
- Ladda ner fulltext (pdf) av Evaluating Melanoma Risk in Adult Mastocytosis: Potential Impact of Detection Bias - A Registry-based Study (Sweden)
Ingår i Journal of Sleep Research, 2025
Ingår i Haematologica, s. 163-172, 2025
Brain Networks Differ According to Levels of Interference in Spatiotemporal Processing
Ingår i Hippocampus, 2025
- DOI för Brain Networks Differ According to Levels of Interference in Spatiotemporal Processing
- Ladda ner fulltext (pdf) av Brain Networks Differ According to Levels of Interference in Spatiotemporal Processing
Ingår i Cancer Gene Therapy, s. 1191-1205, 2025
- DOI för MALNC: a new mutant NPM1/IDH2R140 and PML-RARA-associated lncRNA with impact on AML cell proliferation, maturation and drug response
- Ladda ner fulltext (pdf) av MALNC: a new mutant NPM1/IDH2R140 and PML-RARA-associated lncRNA with impact on AML cell proliferation, maturation and drug response
Ingår i Blood Advances, s. 660-669, 2025
- DOI för PTCy-based graft-versus-host disease prophylaxis for matched sibling donor allogeneic hematopoietic cell transplantation
- Ladda ner fulltext (pdf) av PTCy-based graft-versus-host disease prophylaxis for matched sibling donor allogeneic hematopoietic cell transplantation
Ingår i Haematologica, s. 179-182, 2025
- DOI för Respiratory syncytial virus and other vaccine-preventable infections in multiple myeloma: A population-based study on 8,672 myeloma patients diagnosed 2008-2021 from the Swedish Myeloma Registry
- Ladda ner fulltext (pdf) av Respiratory syncytial virus and other vaccine-preventable infections in multiple myeloma: A population-based study on 8,672 myeloma patients diagnosed 2008-2021 from the Swedish Myeloma Registry
Ingår i International Journal of Circumpolar Health, 2025
- DOI för The meaning of cold bathing in middle aged and elderly people in Sweden: - a phenomenological hermeneutic study
- Ladda ner fulltext (pdf) av The meaning of cold bathing in middle aged and elderly people in Sweden: - a phenomenological hermeneutic study
Ingår i Blood, s. 3139-3152, 2025
Ingår i BMJ Open Gastroenterology, 2025
- DOI för Health-related quality of life in patients with liver cirrhosis following adjunctive nurse-based care versus standard medical care: a pragmatic, multicentre, randomised controlled study
- Ladda ner fulltext (pdf) av Health-related quality of life in patients with liver cirrhosis following adjunctive nurse-based care versus standard medical care: a pragmatic, multicentre, randomised controlled study
Ingår i Journal of clinical apheresis, 2025
- DOI för Hematopoietic Stem Cell Donors' Experiences of Information and Side‐Effects During the First Year After Donation—A Swedish National Study
- Ladda ner fulltext (pdf) av Hematopoietic Stem Cell Donors' Experiences of Information and Side‐Effects During the First Year After Donation—A Swedish National Study
Ingår i Haematologica, s. 1774-1785, 2025
- DOI för Revaccination with pneumococcal conjugate vaccine five years after primary immunization improves immunity in patients with chronic lymphocytic leukemia
- Ladda ner fulltext (pdf) av Revaccination with pneumococcal conjugate vaccine five years after primary immunization improves immunity in patients with chronic lymphocytic leukemia
Income and education affect prognosis and treatment in symptomatic myeloma
Ingår i Annals of Hematology, s. 565-572, 2025
- DOI för Income and education affect prognosis and treatment in symptomatic myeloma
- Ladda ner fulltext (pdf) av Income and education affect prognosis and treatment in symptomatic myeloma
Ingår i Physiological Reports, 2025
- DOI för Regular postexercise sauna bathing does not improve heart rate variability: A multi-arm randomized controlled trial
- Ladda ner fulltext (pdf) av Regular postexercise sauna bathing does not improve heart rate variability: A multi-arm randomized controlled trial
Ingår i eJHaem, 2025
- DOI för High Prevalence of Psychological Symptoms, Sexual Dysfunction, and Prolonged Medical Leave Two Years After Acute Leukemia Diagnosis-Patient Reported Outcome in Sweden
- Ladda ner fulltext (pdf) av High Prevalence of Psychological Symptoms, Sexual Dysfunction, and Prolonged Medical Leave Two Years After Acute Leukemia Diagnosis-Patient Reported Outcome in Sweden
Ingår i Biomarker research, s. 67, 2025
- DOI för The overlooked trio: sleep duration, sampling time and physical exercise alter levels of olink-assessed blood biomarkers of cardiovascular risk.
- Ladda ner fulltext (pdf) av The overlooked trio: sleep duration, sampling time and physical exercise alter levels of olink-assessed blood biomarkers of cardiovascular risk.
Ingår i Multiple Sclerosis Journal, s. 455-463, 2025
- DOI för Patient-reported outcomes of quality of life before and after autologous hematopoietic stem cell transplantation for multiple sclerosis
- Ladda ner fulltext (pdf) av Patient-reported outcomes of quality of life before and after autologous hematopoietic stem cell transplantation for multiple sclerosis
Exploring the impact of opioid use on outcomes in allogeneic hematopoietic stem cell transplantation
Ingår i PLOS ONE, 2025
- DOI för Exploring the impact of opioid use on outcomes in allogeneic hematopoietic stem cell transplantation
- Ladda ner fulltext (pdf) av Exploring the impact of opioid use on outcomes in allogeneic hematopoietic stem cell transplantation
Ingår i American Journal of Physiology - Lung cellular and Molecular Physiology, 2025
- DOI för Allergic airway inflammation amplifies mast cell responses in isolated guinea pig intralobular bronchi
- Ladda ner fulltext (pdf) av Allergic airway inflammation amplifies mast cell responses in isolated guinea pig intralobular bronchi
Ingår i Journal of Neurology, Neurosurgery and Psychiatry, s. 966-974, 2025
- DOI för Factors associated with outcomes following autologous haematopoietic stem cell transplantation for multiple sclerosis
- Ladda ner fulltext (pdf) av Factors associated with outcomes following autologous haematopoietic stem cell transplantation for multiple sclerosis
Dual targeting of G9a and DNMTs induces antitumor effects in multiple myeloma
Ingår i Blood Advances, s. 4825-4841, 2025
- DOI för Dual targeting of G9a and DNMTs induces antitumor effects in multiple myeloma
- Ladda ner fulltext (pdf) av Dual targeting of G9a and DNMTs induces antitumor effects in multiple myeloma
Ingår i Genes, Chromosomes and Cancer, 2025
- DOI för Influence of Cytogenetics on the Outcome of Patients With High-Risk Myelodysplastic Syndrome Including Deletion 5q Treated With Azacitidine With or Without Lenalidomide
- Ladda ner fulltext (pdf) av Influence of Cytogenetics on the Outcome of Patients With High-Risk Myelodysplastic Syndrome Including Deletion 5q Treated With Azacitidine With or Without Lenalidomide
Ingår i Leukemia, s. 675-683, 2025
- DOI för Prognostic impact of expression of CD2, CD25, and/or CD30 in/on mast cells in systemic mastocytosis: a registry study of the European Competence Network on Mastocytosis
- Ladda ner fulltext (pdf) av Prognostic impact of expression of CD2, CD25, and/or CD30 in/on mast cells in systemic mastocytosis: a registry study of the European Competence Network on Mastocytosis
2025
Ingår i Haematologica, s. 1723-1735, 2025
- DOI för Impact of age and sex on survival outcomes inpatients aged 1-45 years with acute lymphoblastic leukemia treated according to the stratification used in the NOPHO ALL2008 trial
- Ladda ner fulltext (pdf) av Impact of age and sex on survival outcomes inpatients aged 1-45 years with acute lymphoblastic leukemia treated according to the stratification used in the NOPHO ALL2008 trial
Ingår i Clinical Cancer Research, s. 3062-3071, 2025
- DOI för Validation of Guidelines for Genetic Investigation of Myeloid Neoplasms with Germline Predisposition: Results from a Prospective Cohort Study
- Ladda ner fulltext (pdf) av Validation of Guidelines for Genetic Investigation of Myeloid Neoplasms with Germline Predisposition: Results from a Prospective Cohort Study
Acute promyelocytic leukemia: long-term outcomes from the HARMONY project
Ingår i Blood, s. 234-243, 2025
Lack of ST2 aggravates glioma invasiveness, vascular abnormality, and immune suppression
Ingår i Neuro-Oncology Advances, 2025
- DOI för Lack of ST2 aggravates glioma invasiveness, vascular abnormality, and immune suppression
- Ladda ner fulltext (pdf) av Lack of ST2 aggravates glioma invasiveness, vascular abnormality, and immune suppression
Ingår i Genome Medicine, 2025
- DOI för Disease-specific epigenetic deregulation of enhancers, transposons, and polycomb targets in acute promyelocytic leukemia
- Ladda ner fulltext (pdf) av Disease-specific epigenetic deregulation of enhancers, transposons, and polycomb targets in acute promyelocytic leukemia
Ingår i Leukemia and Lymphoma, s. 1493-1501, 2024
- DOI för Cytarabine dose intensification improves survival in older patients with secondary/high-risk acute myeloid leukemia in matched real-world versus clinical trial data
- Ladda ner fulltext (pdf) av Cytarabine dose intensification improves survival in older patients with secondary/high-risk acute myeloid leukemia in matched real-world versus clinical trial data
Epidemiology of mastocytosis: a population-based study (Sweden)
Ingår i Acta Oncologica, s. 44-50, 2024
- DOI för Epidemiology of mastocytosis: a population-based study (Sweden)
- Ladda ner fulltext (pdf) av Epidemiology of mastocytosis: a population-based study (Sweden)
Ingår i Leukemia, s. 1072-1080, 2024
- DOI för Management and outcome of patients with chronic myeloid leukemia in blast phase in the tyrosine kinase inhibitor era - analysis of the European LeukemiaNet Blast Phase Registry
- Ladda ner fulltext (pdf) av Management and outcome of patients with chronic myeloid leukemia in blast phase in the tyrosine kinase inhibitor era - analysis of the European LeukemiaNet Blast Phase Registry
Ingår i Bone Marrow Transplantation, s. 1676-1682, 2024
- DOI för Reduced Intensity transplantation vs chemotherapy in CR1: A prospective, pseudorandomized study in 50-70 year old AML patients
- Ladda ner fulltext (pdf) av Reduced Intensity transplantation vs chemotherapy in CR1: A prospective, pseudorandomized study in 50-70 year old AML patients
Ingår i Journal of Internal Medicine, s. 53-67, 2024
- DOI för Early transfusion patterns improve the Molecular International Prognostic Scoring System (IPSS-M) prediction in myelodysplastic syndromes
- Ladda ner fulltext (pdf) av Early transfusion patterns improve the Molecular International Prognostic Scoring System (IPSS-M) prediction in myelodysplastic syndromes
Systemic mastocytosis: dying or survivin
Ingår i Blood, s. 945-947, 2024
Ingår i Leukemia, s. 712-719, 2024
- DOI för Increase in peg-asparaginase clearance as a predictor for inactivation in patients with acute lymphoblastic leukemia
- Ladda ner fulltext (pdf) av Increase in peg-asparaginase clearance as a predictor for inactivation in patients with acute lymphoblastic leukemia
Ingår i Leukemia, s. 1722-1730, 2024
Clinical and Genetic studies in Chronic Myeloid Leukaemia
2024
An optimized method for IgE-mediated degranulation of human lung mast cells
Ingår i Frontiers in Immunology, 2024
- DOI för An optimized method for IgE-mediated degranulation of human lung mast cells
- Ladda ner fulltext (pdf) av An optimized method for IgE-mediated degranulation of human lung mast cells
Ingår i eJHaem, s. 117-124, 2024
- DOI för Allogeneic stem cell transplant recipients surviving at least 2 years without relapse: outcome and risk factors
- Ladda ner fulltext (pdf) av Allogeneic stem cell transplant recipients surviving at least 2 years without relapse: outcome and risk factors
Ingår i BMC Nursing, 2024
- DOI för Patient perceived quality of cirrhosis care – adjunctive nurse-based care versus standard medical care: a pragmatic multicentre randomised controlled study
- Ladda ner fulltext (pdf) av Patient perceived quality of cirrhosis care – adjunctive nurse-based care versus standard medical care: a pragmatic multicentre randomised controlled study
Ingår i Leukemia, s. 109-125, 2024
- DOI för Single-cell analysis of immune recognition in chronic myeloid leukemia patients following tyrosine kinase inhibitor discontinuation
- Ladda ner fulltext (pdf) av Single-cell analysis of immune recognition in chronic myeloid leukemia patients following tyrosine kinase inhibitor discontinuation
Plasma Protein Profiling to Discern Indolent from Advanced Systemic Mastocytosis
Ingår i Journal of Molecular Diagnostics, s. 792-804, 2024
- DOI för Plasma Protein Profiling to Discern Indolent from Advanced Systemic Mastocytosis
- Ladda ner fulltext (pdf) av Plasma Protein Profiling to Discern Indolent from Advanced Systemic Mastocytosis
Ingår i Blood Advances, s. 2890-2900, 2024
- DOI för Serum chemistry profiling and prognostication in systemic mastocytosis: a registry-based study of the ECNM and GREM
- Ladda ner fulltext (pdf) av Serum chemistry profiling and prognostication in systemic mastocytosis: a registry-based study of the ECNM and GREM
The exon-junction complex helicase eIF4A3 holds therapeutic potential in acute myeloid leukemia
Ingår i Leukemia, s. 663-666, 2024
- DOI för The exon-junction complex helicase eIF4A3 holds therapeutic potential in acute myeloid leukemia
- Ladda ner fulltext (pdf) av The exon-junction complex helicase eIF4A3 holds therapeutic potential in acute myeloid leukemia
Ingår i Blood Advances, s. 3941-3945, 2024
- DOI för CRISPR/Cas9-mediated gene disruption determines the roles of MITF and CITED2 in human mast cell differentiation
- Ladda ner fulltext (pdf) av CRISPR/Cas9-mediated gene disruption determines the roles of MITF and CITED2 in human mast cell differentiation