Haematology

The research group conducts clinical research in various forms of leukaemias and myeloproliferative diseases, but also in anaemia treatment and nursing. Through preclinical drug development, participation in a large number of clinical trials and studies based on our population-based cancer registries, we try to develop new treatment methods and better care for affected patients.
Haematology includes both benign and malignant diseases. Among the benign are different forms of cytopenias, both hereditary and aquired, such as anaemias, neutropenias and thrombocytopenias, as well as iron metabolism disorders. The malignant haematologic diseases constitute a heterogeneous group of cancer diseases which are usually caused by uncontrolled growth of blood cells.
In most cases it is immature stem cells that have lost their growth regulation and/or their ability to differentiate into mature effector cells of either the myeloid or the lymphoid lineages. Such loss of control may give rise to both acute and chronic leukemias with overproduction of white blood cells but also to myeloproliferativa neoplasms with over-production of red cells and/or platelets.
Focus of research
The research is conducted by a number of teams, being formed from the knowledge basis of the most important disease fields in haematology.Currently we focus on the following areas:
- Development and testing of new drugs and therapy strategies in malignant haematological diseases; acute myelogenous leukaemia, acute lymphoblastic leukemia, myelodysplastic syndrome, chronic myelogenous leukaemia, chronic lymphocytic leukemia and multiple myeloma.
- Studies bases on the Swedish national, population based quality registries formalignant haematological diseases.
- Translational research in association with the regional biobank project U-CAN.
- Studies on myeloproliferativa neoplasms, cancer anaemia and supportive care.
An important part of the activities of the Haematology group is also leadership and participation in national and international research groups for initiating international studies, and for the development of treatment guidelines and Centres of clinical excellence.
Group members
Publications
Part of Transplantation direct, 2025
- DOI for Impact of Granulocyte Colony-Stimulating Factor (G-CSF) on Clinical Outcomes in Allogeneic Hematopoietic Cell Transplantation: Does Speeding Up Neutrophil Engraftment Make a Difference?
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Part of Haematologica, p. 179-182, 2025
- DOI for Respiratory syncytial virus and other vaccine-preventable infections in multiple myeloma: A population-based study on 8,672 myeloma patients diagnosed 2008-2021 from the Swedish Myeloma Registry
- Download full text (pdf) of Respiratory syncytial virus and other vaccine-preventable infections in multiple myeloma: A population-based study on 8,672 myeloma patients diagnosed 2008-2021 from the Swedish Myeloma Registry
Part of Leukemia and Lymphoma, p. 1493-1501, 2024
- DOI for Cytarabine dose intensification improves survival in older patients with secondary/high-risk acute myeloid leukemia in matched real-world versus clinical trial data
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Epidemiology of mastocytosis: a population-based study (Sweden)
Part of Acta Oncologica, p. 44-50, 2024
- DOI for Epidemiology of mastocytosis: a population-based study (Sweden)
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Part of Leukemia, p. 1072-1080, 2024
- DOI for Management and outcome of patients with chronic myeloid leukemia in blast phase in the tyrosine kinase inhibitor era - analysis of the European LeukemiaNet Blast Phase Registry
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Part of Journal of Internal Medicine, p. 53-67, 2024
- DOI for Early transfusion patterns improve the Molecular International Prognostic Scoring System (IPSS-M) prediction in myelodysplastic syndromes
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Systemic mastocytosis: dying or survivin
Part of Blood, p. 945-947, 2024
Part of Blood Advances, 2024
- DOI for PTCy Based Graft versus Host Disease Prophylaxis for Matched Sibling Donor Allogeneic Hematopoietic Cell Transplantation
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Part of Leukemia, p. 1722-1730, 2024
Clinical and Genetic studies in Chronic Myeloid Leukaemia
2024
An optimized method for IgE-mediated degranulation of human lung mast cells
Part of Frontiers in Immunology, 2024
- DOI for An optimized method for IgE-mediated degranulation of human lung mast cells
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Part of eJHaem, p. 117-124, 2024
- DOI for Allogeneic stem cell transplant recipients surviving at least 2 years without relapse: outcome and risk factors
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Part of BMC Nursing, 2024
- DOI for Patient perceived quality of cirrhosis care – adjunctive nurse-based care versus standard medical care: a pragmatic multicentre randomised controlled study
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Part of Leukemia, p. 109-125, 2024
- DOI for Single-cell analysis of immune recognition in chronic myeloid leukemia patients following tyrosine kinase inhibitor discontinuation
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Plasma Protein Profiling to Discern Indolent from Advanced Systemic Mastocytosis
Part of Journal of Molecular Diagnostics, p. 792-804, 2024
- DOI for Plasma Protein Profiling to Discern Indolent from Advanced Systemic Mastocytosis
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Part of Blood Advances, p. 2890-2900, 2024
- DOI for Serum chemistry profiling and prognostication in systemic mastocytosis: a registry-based study of the ECNM and GREM
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The exon-junction complex helicase eIF4A3 holds therapeutic potential in acute myeloid leukemia
Part of Leukemia, p. 663-666, 2024
- DOI for The exon-junction complex helicase eIF4A3 holds therapeutic potential in acute myeloid leukemia
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Part of Blood Advances, p. 3941-3945, 2024
- DOI for CRISPR/Cas9-mediated gene disruption determines the roles of MITF and CITED2 in human mast cell differentiation
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2024
Part of Bone Marrow Transplantation, p. 403-408, 2024
- DOI for Incidence of cardiovascular disease in healthy Swedish peripheral blood stem cell donors - a nationwide study
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Part of European Journal of Haematology, p. 301-309, 2024
Part of Transplantation and Cellular Therapy, p. 6810-68100000000000, 2024
Part of Cell Reports, 2024
- DOI for Proteome-wide CETSA reveals diverse apoptosisinducing mechanisms converging on an initial apoptosis effector stage at the nuclear periphery
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Part of American Journal of Hematology, p. 1768-1777, 2024
- DOI for Phase 3 randomized COMMODORE 2 trial: Crovalimab versus eculizumab in patients with paroxysmal nocturnal hemoglobinuria naive to complement inhibition
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AL amyloidosis: Study of epidemiology, diagnosis and treatment with emphasis on heart involvement
2024
Part of ESC Heart Failure, p. 44-53, 2024
- DOI for Outcome prediction by myocardial external efficiency from 11C-acetate positron emission tomography in cardiac amyloidosis
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Part of Journal of Neurology, Neurosurgery and Psychiatry, p. 125-133, 2024
- DOI for Haematopoietic stem cell transplantation for treatment of relapsing-remitting multiple sclerosis in Sweden: an observational cohort study
- Download full text (pdf) of Haematopoietic stem cell transplantation for treatment of relapsing-remitting multiple sclerosis in Sweden: an observational cohort study
Part of Bone Marrow Transplantation, p. 1601-1610, 2024
- DOI for BEAM or cyclophosphamide in autologous haematopoietic stem cell transplantation for relapsing-remitting multiple sclerosis
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Delineating functional and molecular impact of ex vivo sample handling in precision medicine
Part of npj Precision Oncology, 2024
- DOI for Delineating functional and molecular impact of ex vivo sample handling in precision medicine
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Part of Journal of Clinical Oncology, 2024
Toll-like receptor activation induces airway obstruction and hyperresponsiveness in guinea pigs
Part of Respiratory Research, 2024
- DOI for Toll-like receptor activation induces airway obstruction and hyperresponsiveness in guinea pigs
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Part of Transplantation and Cellular Therapy, p. 5810-58100000000, 2023
Part of Leukemia, p. 1156-1159, 2023
- DOI for The impact of Covid-19 in patients with chronic myeloid leukemia: a nationwide population-based study
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Part of British Journal of Haematology, p. 353-356, 2023
Part of Blood, p. 73-89, 2023
- DOI for Characterization of the bone marrow niche in patients with chronic myeloid leukemia identifies CXCL14 as a new therapeutic option
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Part of Acta Oncologica, p. 1723-1731, 2023
- DOI for Impact of body mass index on outcome and treatment-related toxicity in young adults with acute lymphoblastic leukemia
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Part of Clinical Cancer Research, p. 2826-2834, 2023
Part of Frontiers in Immunology, 2023
- DOI for Prevention of CMV/EBV reactivation by double-specific T cells in patients after allogeneic stem cell transplantation: results from the randomized phase I/IIa MULTIVIR-01 study
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Increased plasma endostatin and GDF15 in indolent non-Hodgkin lymphoma
Part of Upsala Journal of Medical Sciences, 2023
- DOI for Increased plasma endostatin and GDF15 in indolent non-Hodgkin lymphoma
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Part of PLOS ONE, 2023
- DOI for Feeling safe or falling through the cracks – Patients’ experiences of healthcare in cirrhosis illness: A qualitative study
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Part of Blood Advances, p. 1713-1724, 2023
Invasive fungal infection by Peziza ostracoderma in an immunocompromised patient
Part of Medical Mycology Case Reports, p. 26-30, 2023
- DOI for Invasive fungal infection by Peziza ostracoderma in an immunocompromised patient
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Part of European Journal of Haematology, 2023
- DOI for Despite warnings, co-medication with proton pump inhibitors and dasatinib is common in chronic myeloid leukemia, but XS004, a novel oral dasatinib formulation, provides reduced pH-dependence, minimizing undesirable drug-drug interactions.
- Download full text (pdf) of Despite warnings, co-medication with proton pump inhibitors and dasatinib is common in chronic myeloid leukemia, but XS004, a novel oral dasatinib formulation, provides reduced pH-dependence, minimizing undesirable drug-drug interactions.
MDS-Comorbidity Index using register data has prognostic impact in Swedish MDS patients
Part of Leukemia Research, 2023
- DOI for MDS-Comorbidity Index using register data has prognostic impact in Swedish MDS patients
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Chronic lymphocytic leukemia: Studies on cardiovascular disease, biomarkers and subclones
2023
Impact of daratumumab-based induction on stem cell collection parameters in Swedish myeloma patients
Part of Haematologica, p. 610-614, 2023
- DOI for Impact of daratumumab-based induction on stem cell collection parameters in Swedish myeloma patients
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Part of Frontiers in Immunology, 2023
- DOI for Improved outcomes over time and higher mortality in CMV seropositive allogeneic stem cell transplantation patients with COVID-19: An infectious disease working party study from the European Society for Blood and Marrow Transplantation registry
- Download full text (pdf) of Improved outcomes over time and higher mortality in CMV seropositive allogeneic stem cell transplantation patients with COVID-19: An infectious disease working party study from the European Society for Blood and Marrow Transplantation registry
Part of Journal of Allergy and Clinical Immunology, p. 581-590, 2023
Part of eJHaem, p. 876-881, 2023
- DOI for Next-generation sequencing of baseline genetic mutations and outcomes of eltrombopag and azacitidine therapy in patients with myelodysplastic syndromes and thrombocytopenia: Data from the SUPPORT clinical trial
- Download full text (pdf) of Next-generation sequencing of baseline genetic mutations and outcomes of eltrombopag and azacitidine therapy in patients with myelodysplastic syndromes and thrombocytopenia: Data from the SUPPORT clinical trial
2023