Molecular Epidemiology

Our research focuses on the causes and consequences of diabetes and cardiovascular diseases, the identification of predictive biomarkers and lifestyle factors, and novel methods in disease surveillance.
We apply traditional and modern methods for causal inference in large observational datasets, some of which our team have developed based on high-throughput molecular methods. These data include metabolomics, metagenomics, genomics, proteomics, and imiomics. We have also performed large register linkages and collected COVID-19 data through an innovative national syndromic surveillance app.
We are an international, creative, and collaborative research environment with an ambition to make a positive impact on society. Our research is projected to lead to important new insights into disease mechanisms, which in turn can facilitate the development of new treatments for these diseases, as well as new biomarkers of disease for improved risk prediction and prognostics. Additionally, in response to the COVID-19 pandemic, the group has been striving to develop novel methods for monitoring the transmission of infectious disease agents and for establishing a systematic approach to vaccination safety to safeguard communities in future health crises.
Group members
Research projects
- Dietary meat intake in relation to cardiovascular disease: Understanding molecular mechanisms using plasma metabolome and proteome profiling
- Dog ownership and physical activity in SCAPIS Uppsala
- Evaluation of COVID-19 vaccination appointment letters on uptake across sociodemographics
- Genome-wide association study of the gut microbiome
- Gut microbiota and risk of cardiovascular disease
- Parental health and socioeconomic consequences of caring for children with type 1 diabetes
- Prediction of the gut microbiome from plasma metabolites
- The influence of host traits on the gut microbiome
- The role of gut microbiome, plasma metabolome, and proteome biomarkers in understanding alcohol-induced cardiovascular disease risk
- The Swedish Healthcare Guide 1177 and Symptoms reported through it may aid in surveillance and predict COVID-19 hospital admissions
- Transforming user narratives into vaccine safety signals: Advanced text analysis of syndromic app data in the UK and Sweden
Publications
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Part of Nature Medicine, p. 1351-1361, 2026
- DOI for Antibiotic use and gut microbiome composition links from individual-level prescription data of 14,979 individuals
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Part of Nutrition & Metabolism, 2026
- DOI for Appropriate use of spot-urine sodium estimates for population-level and exploratory analyses: a response to Campbell and Cappuccio
- Download full text (pdf) of Appropriate use of spot-urine sodium estimates for population-level and exploratory analyses: a response to Campbell and Cappuccio
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Part of Kidney International, p. 1004-1013, 2026
- DOI for Association between the gut microbiota and estimated glomerular filtration rate in two Swedish population-based cohorts
- Download full text (pdf) of Association between the gut microbiota and estimated glomerular filtration rate in two Swedish population-based cohorts
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Part of HUMAN-ANIMAL INTERACTIONS, 2026
- DOI for Associations between dog and cat ownership, social integration, mental health and physical activity: A cross-sectional study from the SCAPIS population
- Download full text (pdf) of Associations between dog and cat ownership, social integration, mental health and physical activity: A cross-sectional study from the SCAPIS population
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Dog exposure and subsequent asthma outcomes in children with asthma and allergy
Part of Journal of Allergy and Clinical Immunology, 2026
- DOI for Dog exposure and subsequent asthma outcomes in children with asthma and allergy
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Part of Genes & Nutrition, 2026
- DOI for Genetic variations underlying bitter and sweet taste perception are associated with food and beverage intake habits and taste-modifying behaviors among Dutch adults with a prior myocardial infarction
- Download full text (pdf) of Genetic variations underlying bitter and sweet taste perception are associated with food and beverage intake habits and taste-modifying behaviors among Dutch adults with a prior myocardial infarction
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Part of Nature Genetics, p. 540-549, 2026
- DOI for Genome-wide association analyses highlight the role of the intestinal molecular environment in human gut microbiota variation
- Download full text (pdf) of Genome-wide association analyses highlight the role of the intestinal molecular environment in human gut microbiota variation
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Part of Respiratory Research, 2026
- DOI for Genome-wide association study of image-based emphysema scoring in the Swedish CArdioPulmonary bioImage Study (SCAPIS) suggests two new risk loci in smokers
- Download full text (pdf) of Genome-wide association study of image-based emphysema scoring in the Swedish CArdioPulmonary bioImage Study (SCAPIS) suggests two new risk loci in smokers
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Impact of kidney function on the metabolome in the general population
Part of PLOS ONE, 2026
- DOI for Impact of kidney function on the metabolome in the general population
- Download full text (pdf) of Impact of kidney function on the metabolome in the general population
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Linking Lipidomics to Vulnerable Coronary Plaques: A PROSPECT II Substudy
Part of Arteriosclerosis, Thrombosis and Vascular Biology, 2026
- DOI for Linking Lipidomics to Vulnerable Coronary Plaques: A PROSPECT II Substudy
- Download full text (pdf) of Linking Lipidomics to Vulnerable Coronary Plaques: A PROSPECT II Substudy
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Part of Briefings in Bioinformatics, 2026
- DOI for Metabolomics workbench: data-driven classification and correlation analysis between metabolite classes, biomarkers, and drugs
- Download full text (pdf) of Metabolomics workbench: data-driven classification and correlation analysis between metabolite classes, biomarkers, and drugs
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Part of European Heart Journal, p. 3415-3425, 2026
- DOI for Risk-weighted apoB: a novel summary metric outperforming traditional lipid biomarkers in predicting coronary heart disease
- Download full text (pdf) of Risk-weighted apoB: a novel summary metric outperforming traditional lipid biomarkers in predicting coronary heart disease
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Part of Social Science and Medicine, 2026
- DOI for Sense of coherence and the cultural organisation of barriers to healthy eating and active living in socioeconomically disadvantaged neighbourhoods in Uppsala
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Part of Acta Radiologica, p. 255-263, 2026
- DOI for Soft-tissue and half-value windows outperform bone window in ureteral stone size measurements in non-enhanced computed tomography.
- Download full text (pdf) of Soft-tissue and half-value windows outperform bone window in ureteral stone size measurements in non-enhanced computed tomography.
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The gut microbiome as a fingerprint of antibiotic use history
Part of Nature Medicine, p. 1203-1204, 2026
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Part of Nature Genetics, p. 530-539, 2026
- DOI for The HUNT study identifies host genetic factors reproducibly associated with human gut microbiota composition
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2026
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Part of European Journal of Epidemiology, p. 765-773, 2026
- DOI for Validation of self-reported family history of myocardial infarction using nationwide health care data
- Download full text (pdf) of Validation of self-reported family history of myocardial infarction using nationwide health care data
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When the proteome meets the metabolome observational and Mendelian randomization analyses
Part of Metabolism, 2026
- DOI for When the proteome meets the metabolome observational and Mendelian randomization analyses
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A genome-wide association study of imaging-defined atherosclerosis
Part of Nature Communications, 2025
- DOI for A genome-wide association study of imaging-defined atherosclerosis
- Download full text (pdf) of A genome-wide association study of imaging-defined atherosclerosis
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Part of Vaccine, 2025
- DOI for Adverse drug reactions following SARS-CoV-2 vaccination of 3805 healthcare workers cause substantial sick-leave and are correlated to vaccine regimen, age, sex and serological response
- Download full text (pdf) of Adverse drug reactions following SARS-CoV-2 vaccination of 3805 healthcare workers cause substantial sick-leave and are correlated to vaccine regimen, age, sex and serological response
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Associations between physical activity and CVD-related metabolomic and proteomic biomarkers
Part of PLOS ONE, 2025
- DOI for Associations between physical activity and CVD-related metabolomic and proteomic biomarkers
- Download full text (pdf) of Associations between physical activity and CVD-related metabolomic and proteomic biomarkers
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Bereavement and type 1 diabetes in childhood: a register-based cohort study in Sweden
Part of Diabetologia, p. 549-556, 2025
- DOI for Bereavement and type 1 diabetes in childhood: a register-based cohort study in Sweden
- Download full text (pdf) of Bereavement and type 1 diabetes in childhood: a register-based cohort study in Sweden
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Part of EBioMedicine, 2025
- DOI for Cardio-metabolic-related plasma proteins reveal biological links between cardiovascular diseases and fragility fractures: a cohort and Mendelian randomisation investigation
- Download full text (pdf) of Cardio-metabolic-related plasma proteins reveal biological links between cardiovascular diseases and fragility fractures: a cohort and Mendelian randomisation investigation
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Part of European Heart Journal, p. 147-157, 2025
- DOI for Cardiovascular events following coronavirus disease 2019 vaccination in adults: a nationwide Swedish study
- Download full text (pdf) of Cardiovascular events following coronavirus disease 2019 vaccination in adults: a nationwide Swedish study
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Part of European Journal of Public Health, p. 795-802, 2025
- DOI for Effect of COVID-19 vaccination appointment letters on uptake by sociodemographic characteristics: a regression discontinuity analysis in Sweden, December 2020 to September 2021
- Download full text (pdf) of Effect of COVID-19 vaccination appointment letters on uptake by sociodemographic characteristics: a regression discontinuity analysis in Sweden, December 2020 to September 2021
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Part of Diabetologia, p. 1078-1079, 2025
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Part of Journal of Clinical Endocrinology and Metabolism, 2025
- DOI for Identification of gut microbiome signatures and metabolites associated with albuminuria in type 2 diabetes
- Download full text (pdf) of Identification of gut microbiome signatures and metabolites associated with albuminuria in type 2 diabetes
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Impact of genetic variants linked to liver fat and liver volume on MRI-mapped body composition
Part of JHEP Reports, 2025
- DOI for Impact of genetic variants linked to liver fat and liver volume on MRI-mapped body composition
- Download full text (pdf) of Impact of genetic variants linked to liver fat and liver volume on MRI-mapped body composition
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Part of International Journal of Cardiology, 2025
- DOI for Lipoproteins and lipoprotein lipid composition are associated with stages of dysglycemia and subclinical coronary atherosclerosis
- Download full text (pdf) of Lipoproteins and lipoprotein lipid composition are associated with stages of dysglycemia and subclinical coronary atherosclerosis
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Low-fibre diet is associated with high-risk coronary plaque features
Part of Cardiovascular Research, p. 1204-1214, 2025
- DOI for Low-fibre diet is associated with high-risk coronary plaque features
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Meat intake in relation to composition and function of gut microbiota
Part of Clinical Nutrition, p. 124-133, 2025
- DOI for Meat intake in relation to composition and function of gut microbiota
- Download full text (pdf) of Meat intake in relation to composition and function of gut microbiota
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Part of Metabolism, 2025
- DOI for Plasma metabolite profiles of meat intake and their association with cardiovascular disease risk: A population-based study in Swedish cohorts
- Download full text (pdf) of Plasma metabolite profiles of meat intake and their association with cardiovascular disease risk: A population-based study in Swedish cohorts
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Part of Cardiovascular Research, p. 1649-1652, 2025
- DOI for Plasma proteomic and metabolomic profiling of coronary and carotid atherosclerosis in the SCAPIS study: differences and similarities
- Download full text (pdf) of Plasma proteomic and metabolomic profiling of coronary and carotid atherosclerosis in the SCAPIS study: differences and similarities
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Precision nutrition for cardiometabolic diseases
Part of Nature Medicine, p. 1444-1453, 2025
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Precision Omics Initiative Sweden (PROMISE) will integrate research with healthcare
Part of Nature Medicine, p. 1730-1732, 2025
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Proteins associated with preserved ratio impaired spirometry
Part of ERJ Open Research, 2025
- DOI for Proteins associated with preserved ratio impaired spirometry
- Download full text (pdf) of Proteins associated with preserved ratio impaired spirometry
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Raising the bar for publication of Mendelian randomisation studies in Diabetologia.
Part of Diabetologia, p. 2088-2091, 2025
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Part of Metabolism, 2025
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The association between the gut microbiome and 24-h blood pressure measurements in the SCAPIS study
Part of Communications Medicine, 2025
- DOI for The association between the gut microbiome and 24-h blood pressure measurements in the SCAPIS study
- Download full text (pdf) of The association between the gut microbiome and 24-h blood pressure measurements in the SCAPIS study
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Part of eBioMedicine, 2025
- DOI for The circulating dihydrotestosterone/testosterone ratio is increased by gut microbial 5α-reductase activity in females
- Download full text (pdf) of The circulating dihydrotestosterone/testosterone ratio is increased by gut microbial 5α-reductase activity in females
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Part of Diabetologia, p. 2168-2178, 2025
- DOI for The impact of child type 1 diabetes on parental incomes in a welfare state context: quasi-experimental evidence from Swedish national registers
- Download full text (pdf) of The impact of child type 1 diabetes on parental incomes in a welfare state context: quasi-experimental evidence from Swedish national registers
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The metabolic signature of salt intake: a cross-sectional analysis from the SCAPIS-study
Part of Nutrition & Metabolism, 2025
- DOI for The metabolic signature of salt intake: a cross-sectional analysis from the SCAPIS-study
- Download full text (pdf) of The metabolic signature of salt intake: a cross-sectional analysis from the SCAPIS-study
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The urinary microbiome in association with diabetes and diabetic kidney disease: A systematic review
Part of PLOS ONE, 2025
- DOI for The urinary microbiome in association with diabetes and diabetic kidney disease: A systematic review
- Download full text (pdf) of The urinary microbiome in association with diabetes and diabetic kidney disease: A systematic review
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Part of Scientific Reports, 2025
- DOI for Time series anomaly detection in helpline call trends for early detection of COVID-19 spread across Sweden, 2020
- Download full text (pdf) of Time series anomaly detection in helpline call trends for early detection of COVID-19 spread across Sweden, 2020
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Part of European Journal of Epidemiology, p. 1431-1439, 2025
- DOI for Who got tested and who got sick?: Sociodemographic inequalities in COVID-19 testing and hospitalization among 1.48 million individuals in Sweden
- Download full text (pdf) of Who got tested and who got sick?: Sociodemographic inequalities in COVID-19 testing and hospitalization among 1.48 million individuals in Sweden
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Part of Food & Nutrition Research, 2024
- DOI for A Swedish dietary guideline index, gut microbial α-diversity and prevalence of metabolic syndrome - observations in the Swedish CArdioPulmonary bioImage Study (SCAPIS)
- Download full text (pdf) of A Swedish dietary guideline index, gut microbial α-diversity and prevalence of metabolic syndrome - observations in the Swedish CArdioPulmonary bioImage Study (SCAPIS)
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Part of EBioMedicine, 2024
- DOI for Accelerometer-based physical activity is associated with the gut microbiota in 8416 individuals in SCAPIS
- Download full text (pdf) of Accelerometer-based physical activity is associated with the gut microbiota in 8416 individuals in SCAPIS
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Analysis of plasma metabolomes from 11 309 subjects in five population-based cohorts
Part of Scientific Reports, p. 8933, 2024
- DOI for Analysis of plasma metabolomes from 11 309 subjects in five population-based cohorts
- Download full text (pdf) of Analysis of plasma metabolomes from 11 309 subjects in five population-based cohorts
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Associations between epigenetic aging and diabetes mellitus in a Swedish longitudinal study
Part of GeroScience, p. 5003-5014, 2024
- DOI for Associations between epigenetic aging and diabetes mellitus in a Swedish longitudinal study
- Download full text (pdf) of Associations between epigenetic aging and diabetes mellitus in a Swedish longitudinal study