Dietary meat intake in relation to cardiovascular disease: Understanding molecular mechanisms using plasma metabolome and proteome profiling

Project description

Higher meat intake has been reported to be associated with a higher risk of CVD. However, little is known about the underlying biological pathways explaining this association. Metabolomic and proteomic profiling is a promising approach both for quantifying habitual meat intake and to reveal mechanisms underlying disease development.

We aim to identify the association between intake of white and red meat, both unprocessed and processed, and plasma metabolite and protein biomarkers and study their links with CVD risk using large-scale epidemiological cohorts. The cohorts involved are the Swedish CardioPulmonary BioImage Study (SCAPIS), the Swedish Infrastructure for Medical Population-Based Life-Course and Environmental Research (SIMPLER), EpiHealth, and the Prospective Investigation of Obesity, Energy, and Metabolism (POEM).

This inter-disciplinary project will contribute to our biological and clinical understanding of the mechanisms driving CVD risk in individuals with both low and high meat intake.