Endokrin tumörbiologi

Vi utgör en del av ett nationellt center för neuroendokrina tumörer och fokuserar vår forskning på två tumörsjukdomar; multipel endokrin neoplasi typ1 syndrom (MEN1) och binjurebarkscancer. Vi försöker förstå de grundläggande orsakerna bakom dessa sjukdomar, och försöker också omsätta våra resultat och erfarenheter till klinisk praxis genom till exempel kliniska prövningar.

Beskrivning av vår forskning

Bärare med mutationer i genen MEN1 utvecklar tumörer i olika endokrina organ som bisköldskörteln, bukspottkörten och hypofysen. MEN1 tros vara en tumörsuppressorgen, men det är inte känt varför inaktivering av genen orsakar tumörer i endokrina organ och i bara vissa. Vi försöker besvara dessa frågor genom att analysera konsekvenser av MEN1 inaktivering och studera andra faktorer som kan samverka med MEN1. I våra experiment använder vi en lång rad cell- och molekylärbiologiska metoder, och såväl musmodeller som tumörvävnad från patienter. Genom att vi har kliniska data och material från ett 60-tal MEN1 familjer som vi följer kan vi omsätta våra grundläggande studier till klinsk nytta, till exempel i form av prospektiva kliniska studier.

Vårt andra forskningsområde rör binjurebarkscancer, en aggressiv cancer med dålig prognos, som har sitt ursprung i steroidhormonproducerande celler, vilket kan ge distinkta symptom. För att avgöra vilken av tillgängliga behandlingar som är bäst har vi intierat och, tillsammans med flera samarbetspartners, genomfört en randomiserad klinisk studie (FIRM-ACT), där drygt 300 patienter ingick.

Gruppmedlemmar

Forskningsledare: Britt Skogseid

Gruppmedlemmar: Duska Bajic, Yvette Bernardo, Mikael Björk, Joakim Crona, Adam Edholm, Barbro Eriksson, Lovisa Falkman, Katarzyna Fröss-Baron, Tanweera Shaheena Khan, Su-Chen Li, Kazhan Mollazadegan, Azita Monazzam, Hanna-Linn Wargelius, Liang Zhang, Kjell Öberg

Publikationer

Carcinoid heart disease in patients with advanced small-intestinal neuroendocrine tumors and carcinoid syndrome: a retrospective experience from two European referral centers

Algeri, L.; Falkman, Lovisa; Spada, F.; Frassoni, S. et al.

Ingår i ESMO Open, 2024
- DOI för Carcinoid heart disease in patients with advanced small-intestinal neuroendocrine tumors and carcinoid syndrome: a retrospective experience from two European referral centers
- Ladda ner fulltext (pdf) av Carcinoid heart disease in patients with advanced small-intestinal neuroendocrine tumors and carcinoid syndrome: a retrospective experience from two European referral centers
The evolutionary history of metastatic pancreatic neuroendocrine tumours reveals a therapy driven route to high-grade transformation

Backman, Samuel; Botling, Johan; Nord, Helena; Ghosal, Suman et al.

Ingår i Journal of Pathology, s. 357-370, 2024
- DOI för The evolutionary history of metastatic pancreatic neuroendocrine tumours reveals a therapy driven route to high-grade transformation
- Ladda ner fulltext (pdf) av The evolutionary history of metastatic pancreatic neuroendocrine tumours reveals a therapy driven route to high-grade transformation
Reinventing ESMO after the COVID-19 pandemic: moving towards a sustainable academic society

Crona, Joakim; Lee, R.; Sobczuk, P.; Wysoki, O. et al.

Ingår i ESMO Open, 2024
- DOI för Reinventing ESMO after the COVID-19 pandemic: moving towards a sustainable academic society
- Ladda ner fulltext (pdf) av Reinventing ESMO after the COVID-19 pandemic: moving towards a sustainable academic society
Genetics-guided therapy in neuroendocrine carcinoma: response to BRAF- and MEK-inhibitors

Falkman, Lovisa; Sundin, Anders; Skogseid, Britt; Botling, Johan et al.

Ingår i Upsala Journal of Medical Sciences, 2024
- DOI för Genetics-guided therapy in neuroendocrine carcinoma: response to BRAF- and MEK-inhibitors
- Ladda ner fulltext (pdf) av Genetics-guided therapy in neuroendocrine carcinoma: response to BRAF- and MEK-inhibitors
Diagnosis and management of urinary bladder paragangliomas: A Sino-American-European retrospective observational study

Pang, Yingxian; Zhang, Jing; Jiang, Jingjing; Pamporaki, Christina et al.

Ingår i Clinical Endocrinology, s. 234-242, 2024
- DOI för Diagnosis and management of urinary bladder paragangliomas: A Sino-American-European retrospective observational study
Management of phaeochromocytoma and paraganglioma in patients with germline SDHB pathogenic variants: an international expert Consensus statement

Taïeb, David; Nölting, Svenja; Perrier, Nancy D.; Fassnacht, Martin et al.

Ingår i Nature Reviews Endocrinology, s. 168-184, 2024
- DOI för Management of phaeochromocytoma and paraganglioma in patients with germline SDHB pathogenic variants: an international expert Consensus statement
Response to Letter to the Editor regarding 'Risk of complications after core needle biopsy in pheochromocytoma/paraganglioma'

Zhang, Liang; Åkerström, Tobias; Mollazadegan, Kazhan; Beuschlein, Felix et al.

Ingår i Endocrine-Related Cancer, 2024
- DOI för Response to Letter to the Editor regarding 'Risk of complications after core needle biopsy in pheochromocytoma/paraganglioma'
Immune signature of pheochromocytoma and paraganglioma in context of neuroendocrine neoplasms associated with prognosis

Ghosal, Suman; Vanova, Katerina Hadrava; Uher, Ondrej; Das, Shaoli et al.

Ingår i Endocrine, s. 171-179, 2023
- DOI för Immune signature of pheochromocytoma and paraganglioma in context of neuroendocrine neoplasms associated with prognosis
Overall Survival in Patients with Stage IV Pan-NET Eligible for Liver Transplantation

Kjaer, Josefine; Smith, Sara; Hellman, Per; Stålberg, Peter et al.

Ingår i World Journal of Surgery, s. 340-347, 2023
- DOI för Overall Survival in Patients with Stage IV Pan-NET Eligible for Liver Transplantation
- Ladda ner fulltext (pdf) av Overall Survival in Patients with Stage IV Pan-NET Eligible for Liver Transplantation
ENETS standardized (synoptic) reporting for radiological imaging in neuroendocrine tumours

Dromain, Clarisse; Vullierme, Marie-Pierre; Hicks, Rodney J.; Prasad, Vikas et al.

Ingår i Journal of neuroendocrinology, 2022
- DOI för ENETS standardized (synoptic) reporting for radiological imaging in neuroendocrine tumours
- Ladda ner fulltext (pdf) av ENETS standardized (synoptic) reporting for radiological imaging in neuroendocrine tumours
Long-Term Treatment with Telotristat Ethyl in Patients with Carcinoid Syndrome Symptoms: Results from the TELEPATH Study

Hörsch, Dieter; Anthony, Lowell; Gross, David J.; Valle, Juan et al.

Ingår i Neuroendocrinology, s. 298-309, 2022
- DOI för Long-Term Treatment with Telotristat Ethyl in Patients with Carcinoid Syndrome Symptoms: Results from the TELEPATH Study
- Ladda ner fulltext (pdf) av Long-Term Treatment with Telotristat Ethyl in Patients with Carcinoid Syndrome Symptoms: Results from the TELEPATH Study
Benefit of Primary Tumor Resection in Stage IV, Grade 1 and 2, Pancreatic Neuroendocrine Tumors: A Propensity-Score Matched Cohort Study

Kjaer, Josefin; Clancy, Thomas E.; Thornell, Anders; Andersson, Niklas et al.

Ingår i Annals of Surgery Open, 2022
- DOI för Benefit of Primary Tumor Resection in Stage IV, Grade 1 and 2, Pancreatic Neuroendocrine Tumors: A Propensity-Score Matched Cohort Study
- Ladda ner fulltext (pdf) av Benefit of Primary Tumor Resection in Stage IV, Grade 1 and 2, Pancreatic Neuroendocrine Tumors: A Propensity-Score Matched Cohort Study
Poor outcome after systemic therapy in secondary high-grade pancreatic neuroendocrine tumors

Mollazadegan, Kazhan; Skogseid, Britt; Botling, Johan; Åkerström, Tobias et al.

Ingår i Endocrine Connections, 2022
- DOI för Poor outcome after systemic therapy in secondary high-grade pancreatic neuroendocrine tumors
- Ladda ner fulltext (pdf) av Poor outcome after systemic therapy in secondary high-grade pancreatic neuroendocrine tumors
A Multinational Pilot Study on Patients' Perceptions of Advanced Neuroendocrine Neoplasms on the EORTC QLQ-C30 and EORTC QLQ-GINET21 Questionnaires

van Leeuwaarde, Rachel S.; Gonzalez-Clavijo, Angelica M.; Pracht, Marc; Emelianova, Galina et al.

Ingår i Journal of Clinical Medicine, 2022
- DOI för A Multinational Pilot Study on Patients' Perceptions of Advanced Neuroendocrine Neoplasms on the EORTC QLQ-C30 and EORTC QLQ-GINET21 Questionnaires
- Ladda ner fulltext (pdf) av A Multinational Pilot Study on Patients' Perceptions of Advanced Neuroendocrine Neoplasms on the EORTC QLQ-C30 and EORTC QLQ-GINET21 Questionnaires
Targeted Therapies in Pheochromocytoma and Paraganglioma

Wang, Katharina; Crona, Joakim; Beuschlein, Felix; Grossman, Ashley B. et al.

Ingår i Journal of Clinical Endocrinology and Metabolism, s. 2963-2972, 2022
- DOI för Targeted Therapies in Pheochromocytoma and Paraganglioma
Consensus on molecular imaging and theranostics in neuroendocrine neoplasms

Ambrosini, Valentina; Kunikowska, Jolanta; Baudin, Eric; Bodei, Lisa et al.

Ingår i European Journal of Cancer, s. 56-73, 2021
- DOI för Consensus on molecular imaging and theranostics in neuroendocrine neoplasms
Cardiac Imaging in Carcinoid Heart Disease

Baron, Tomasz; Bergsten, Johannes; Albåge, Anders; Lundin, Lennart et al.

Ingår i JACC Cardiovascular Imaging, s. 2240-2253, 2021
- DOI för Cardiac Imaging in Carcinoid Heart Disease
ENSAT registry-based randomized clinical trials for adrenocortical carcinoma

Crona, Joakim; Baudin, Eric; Terzolo, Massimo; Chrisoulidou, Alexandra et al.

Ingår i European Journal of Endocrinology, 2021
- DOI för ENSAT registry-based randomized clinical trials for adrenocortical carcinoma
Antiproliferative Systemic Therapies for Metastatic Small Bowel Neuroendocrine Tumours

Dawod, Mohammed; Alonso Gordoa, Teresa; Cives, Mauro; De Mestier, Louis et al.

Ingår i Current Treatment Options in Oncology, 2021
- DOI för Antiproliferative Systemic Therapies for Metastatic Small Bowel Neuroendocrine Tumours
Tumour Growth Rate to predict the outcome of patients with Neuroendocrine Tumours: Performance and sources of variability

Dromain, Clarisse; Sundin, Anders; Najran, Pavan; Vidal Trueba, Hector et al.

Ingår i Neuroendocrinology, s. 831-839, 2021
- DOI för Tumour Growth Rate to predict the outcome of patients with Neuroendocrine Tumours: Performance and sources of variability
177Lu-DOTATATE Therapy of Advanced Pancreatic Neuroendocrine Tumors Heavily Pretreated With Chemotherapy: Analysis of Outcome, Safety and Their Determinants

Fröss-Baron, Katarzyna; Garske, Ulrike; Welin, Staffan; Granberg, Dan et al.

Ingår i Neuroendocrinology, s. 330-343, 2021
- DOI för 177Lu-DOTATATE Therapy of Advanced Pancreatic Neuroendocrine Tumors Heavily Pretreated With Chemotherapy: Analysis of Outcome, Safety and Their Determinants
- Ladda ner fulltext (pdf) av 177Lu-DOTATATE Therapy of Advanced Pancreatic Neuroendocrine Tumors Heavily Pretreated With Chemotherapy: Analysis of Outcome, Safety and Their Determinants
High-Specific-Activity-¹³¹I-MIBG versus ¹⁷⁷Lu-DOTATATE Targeted Radionuclide Therapy for Metastatic Pheochromocytoma and Paraganglioma

Jha, Abhishek; Taïeb, David; Carrasquillo, Jorge A.; Pryma, Daniel A. et al.

Ingår i Clinical Cancer Research, s. 2989-2995, 2021
- DOI för High-Specific-Activity-¹³¹I-MIBG versus ¹⁷⁷Lu-DOTATATE Targeted Radionuclide Therapy for Metastatic Pheochromocytoma and Paraganglioma
Advanced small-bowel well-differentiated neuroendocrine tumours: An international survey of practice on 3(rd)-line treatment

Lamarca, Angela; Cives, Mauro; de Mestier, Louis; Crona, Joakim et al.

Ingår i World Journal of Gastroenterology, s. 976-989, 2021
- DOI för Advanced small-bowel well-differentiated neuroendocrine tumours: An international survey of practice on 3(rd)-line treatment
MiR-486-3p was downregulated at microRNA profiling of adrenals of multiple endocrine neoplasia type 1 mice, and inhibited human adrenocortical carcinoma cell lines

Li, Su-Chen; Monazzam, Azita; Razmara, Masoud; Chu, Xia et al.

Ingår i Scientific Reports, 2021
- DOI för MiR-486-3p was downregulated at microRNA profiling of adrenals of multiple endocrine neoplasia type 1 mice, and inhibited human adrenocortical carcinoma cell lines
- Ladda ner fulltext (pdf) av MiR-486-3p was downregulated at microRNA profiling of adrenals of multiple endocrine neoplasia type 1 mice, and inhibited human adrenocortical carcinoma cell lines
A multigenomic liquid biopsy biomarker for neuroendocrine tumor disease outperforms CgA and has surgical and clinical utility

Modlin, I. M.; Kidd, M.; Falconi, M.; Filosso, P. L. et al.

Ingår i Annals of Oncology, s. 1425-1433, 2021
- DOI för A multigenomic liquid biopsy biomarker for neuroendocrine tumor disease outperforms CgA and has surgical and clinical utility
Early Identification of Residual Disease After Neuroendocrine Tumor Resection Using a Liquid Biopsy Multigenomic mRNA Signature (NETest)

Modlin, Irvin M.; Kidd, Mark; Öberg, Kjell; Falconi, Massimo et al.

Ingår i Annals of Surgical Oncology, s. 7506-7517, 2021
- DOI för Early Identification of Residual Disease After Neuroendocrine Tumor Resection Using a Liquid Biopsy Multigenomic mRNA Signature (NETest)
Systemic Treatment of Gastroenteropancreatic Neuroendocrine Carcinoma

Mollazadegan, Kazhan; Welin, Staffan; Crona, Joakim

Ingår i Current Treatment Options in Oncology, 2021
- DOI för Systemic Treatment of Gastroenteropancreatic Neuroendocrine Carcinoma
- Ladda ner fulltext (pdf) av Systemic Treatment of Gastroenteropancreatic Neuroendocrine Carcinoma
Multiple Endocrine Neoplasia Type 1 and the Pancreas: Diagnosis and Treatment of Functioning and Non-Functioning Pancreatic and Duodenal Neuroendocrine Neoplasia within the MEN1 Syndrome - An International Consensus Statement

Niederle, Bruno; Selberherr, Andreas; Bartsch, Detlef K.; Brandi, Maria L. et al.

Ingår i Neuroendocrinology, s. 609-630, 2021
- DOI för Multiple Endocrine Neoplasia Type 1 and the Pancreas: Diagnosis and Treatment of Functioning and Non-Functioning Pancreatic and Duodenal Neuroendocrine Neoplasia within the MEN1 Syndrome - An International Consensus Statement
¹⁸F-Radiolabeling and Preliminary Evaluation of a HSP₉₀ ligand

Nordeman, Patrik; Jayendra, Z. P.; Briard, E.; Li, Su-Chen et al.

Ingår i European Journal of Pharmaceutical Sciences, 2021
- DOI för ¹⁸F-Radiolabeling and Preliminary Evaluation of a HSP₉₀ ligand
Tumor growth rate in pancreatic neuroendocrine tumor patients undergoing PRRT with 177Lu-DOTATATE.

Pettersson, Olof; Fröss-Baron, Katarzyna; Crona, Joakim; Sundin, Anders

Ingår i Endocrine Connections, s. 422-431, 2021
- DOI för Tumor growth rate in pancreatic neuroendocrine tumor patients undergoing PRRT with 177Lu-DOTATATE.
- Ladda ner fulltext (pdf) av Tumor growth rate in pancreatic neuroendocrine tumor patients undergoing PRRT with 177Lu-DOTATATE.
Para-chloro-2-[¹⁸F]fluoroethyl-etomidate: A promising new PET radiotracer for adrenocortical imaging

Silins, Isabella; Sundin, Anders; Nordeman, Patrik; Jahan, Mahabuba et al.

Ingår i International Journal of Medical Sciences, s. 2187-2196, 2021
- DOI för Para-chloro-2-[¹⁸F]fluoroethyl-etomidate: A promising new PET radiotracer for adrenocortical imaging
- Ladda ner fulltext (pdf) av Para-chloro-2-[¹⁸F]fluoroethyl-etomidate: A promising new PET radiotracer for adrenocortical imaging
Symptom Diaries of Patients with Midgut Neuroendocrine Tumors Treated with ¹⁷⁷Lu-DOTATATE

Strosberg, Jonathan R.; Srirajaskanthan, Rajaventhan; El-Haddad, Ghassan; Wolin, Edward M. et al.

Ingår i Journal of Nuclear Medicine, s. 1712-1718, 2021
- DOI för Symptom Diaries of Patients with Midgut Neuroendocrine Tumors Treated with ¹⁷⁷Lu-DOTATATE
- Ladda ner fulltext (pdf) av Symptom Diaries of Patients with Midgut Neuroendocrine Tumors Treated with ¹⁷⁷Lu-DOTATATE
Whole genome sequencing of apparently mutation-negative MEN1 patients

Backman, Samuel; Bajic, Duska; Crona, Joakim; Hellman, Per et al.

Ingår i European Journal of Endocrinology, s. 35-45, 2020
- DOI för Whole genome sequencing of apparently mutation-negative MEN1 patients
Molecular profiling of neuroendocrine tumours to predict response and toxicity to peptide receptor radionuclide therapy

Bodei, Lisa; Schoeder, Heiko; Baum, Richard P.; Herrmann, Ken et al.

Ingår i The Lancet Oncology, 2020
- DOI för Molecular profiling of neuroendocrine tumours to predict response and toxicity to peptide receptor radionuclide therapy
High-grade progression confers poor survival in pancreatic neuroendocrine tumors

Botling, Johan; Lamarca, Angela; Bajic, Duska; Norlén, Olov et al.

Ingår i Neuroendocrinology, s. 891-898, 2020
- DOI för High-grade progression confers poor survival in pancreatic neuroendocrine tumors
Neuroendocrine Neoplasms of the Small Bowel and Pancreas

Clift, Ashley Kieran; Kidd, Mark; Bodei, Lisa; Toumpanakis, Christos et al.

Ingår i Neuroendocrinology, s. 444-476, 2020
- DOI för Neuroendocrine Neoplasms of the Small Bowel and Pancreas
Long intergenic noncoding RNA profiles of pheochromocytoma and paraganglioma: A novel prognostic biomarker

Ghosal, Suman; Das, Shaoli; Pang, Ying; Gonzales, Melissa K. et al.

Ingår i International Journal of Cancer, s. 2326-2335, 2020
- DOI för Long intergenic noncoding RNA profiles of pheochromocytoma and paraganglioma: A novel prognostic biomarker
Genetics, diagnosis, management and future directions of research of phaeochromocytoma and paraganglioma: a position statement and consensus of the Working Group on Endocrine Hypertension of the European Society of Hypertension

Lenders, Jacques W. M.; Kerstens, Michiel N.; Amar, Laurence; Prejbisz, Aleksander et al.

Ingår i Journal of Hypertension, s. 1443-1456, 2020
- DOI för Genetics, diagnosis, management and future directions of research of phaeochromocytoma and paraganglioma: a position statement and consensus of the Working Group on Endocrine Hypertension of the European Society of Hypertension
An Assessment of Circulating Chromogranin A as a Biomarker of Bronchopulmonary Neuroendocrine Neoplasia: A Systematic Review and Meta-Analysis

Malczewska, Anna; Kidd, Mark; Matar, Somer; Kos-Kudla, Beata et al.

Ingår i Neuroendocrinology, s. 198-216, 2020
- DOI för An Assessment of Circulating Chromogranin A as a Biomarker of Bronchopulmonary Neuroendocrine Neoplasia: A Systematic Review and Meta-Analysis
The clinical applications of a multigene liquid biopsy (NETest) in neuroendocrine tumors

Malczewska, Anna; Kos-Kudla, Beata; Kidd, Mark; Drozdov, Ignat et al.

Ingår i Advances in Medical Sciences, s. 18-29, 2020
- DOI för The clinical applications of a multigene liquid biopsy (NETest) in neuroendocrine tumors
- Ladda ner fulltext (pdf) av The clinical applications of a multigene liquid biopsy (NETest) in neuroendocrine tumors
Blood Chromogranin A Is Not Effective as a Biomarker for Diagnosis or Management of Bronchopulmonary Neuroendocrine Tumors/Neoplasms

Matar, Somer; Malczewska, Anna; Öberg, Kjell; Bodei, Lisa et al.

Ingår i Neuroendocrinology, s. 185-197, 2020
- DOI för Blood Chromogranin A Is Not Effective as a Biomarker for Diagnosis or Management of Bronchopulmonary Neuroendocrine Tumors/Neoplasms
Generation and characterization of CRISPR/Cas9-mediated MEN1 knockout BON1 cells: a human pancreatic neuroendocrine cell line

Monazzam, Azita; Li, Su-Chen; Wargelius, Hanna-Linn; Razmara, Masoud et al.

Ingår i Scientific Reports, 2020
- DOI för Generation and characterization of CRISPR/Cas9-mediated MEN1 knockout BON1 cells: a human pancreatic neuroendocrine cell line
- Ladda ner fulltext (pdf) av Generation and characterization of CRISPR/Cas9-mediated MEN1 knockout BON1 cells: a human pancreatic neuroendocrine cell line
Whole‐genome sequencing of synchronous thyroid carcinomas identifies aberrant DNA repair in thyroid cancer dedifferentiation

Paulsson, Johan O.; Backman, Samuel; Wang, Na; Stenman, Adam et al.

Ingår i Journal of Pathology, s. 183-194, 2020
- DOI för Whole‐genome sequencing of synchronous thyroid carcinomas identifies aberrant DNA repair in thyroid cancer dedifferentiation
Gastroenteropancreatic neuroendocrine neoplasms: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

Pavel, M.; Öberg, Kjell; Falconi, M.; Krenning, E. P. et al.

Ingår i Annals of Oncology, s. 844-860, 2020
- DOI för Gastroenteropancreatic neuroendocrine neoplasms: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Tumor Contrast-Enhancement for Monitoring of PRRT Lu-177-DOTATATE in Pancreatic Neuroendocrine Tumor Patients

Pettersson, Olof; Fröss-Baron, Katarzyna; Crona, Joakim; Sundin, Anders

Ingår i Frontiers in Oncology, 2020
- DOI för Tumor Contrast-Enhancement for Monitoring of PRRT Lu-177-DOTATATE in Pancreatic Neuroendocrine Tumor Patients
- Ladda ner fulltext (pdf) av Tumor Contrast-Enhancement for Monitoring of PRRT Lu-177-DOTATATE in Pancreatic Neuroendocrine Tumor Patients
Kidney dosimetry in 777 patients during ¹⁷⁷Lu-DOTATATE therapy: aspects on extrapolations and measurement time points

Sandström, Mattias; Freedman, Nanette; Fröss-Baron, Katarzyna; Khan, Tanweera et al.

Ingår i EJNMMI Physics, 2020
- DOI för Kidney dosimetry in 777 patients during ¹⁷⁷Lu-DOTATATE therapy: aspects on extrapolations and measurement time points
- Ladda ner fulltext (pdf) av Kidney dosimetry in 777 patients during ¹⁷⁷Lu-DOTATATE therapy: aspects on extrapolations and measurement time points
Impact of liver tumour burden, alkaline phosphatase elevation, and target lesion size on treatment outcomes with Lu-177-Dotatate: an analysis of the NETTER-1 study

Strosberg, Jonathan; Kunz, Pamela L.; Hendifar, Andrew; Yao, James et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 2372-2382, 2020
- DOI för Impact of liver tumour burden, alkaline phosphatase elevation, and target lesion size on treatment outcomes with Lu-177-Dotatate: an analysis of the NETTER-1 study
- Ladda ner fulltext (pdf) av Impact of liver tumour burden, alkaline phosphatase elevation, and target lesion size on treatment outcomes with Lu-177-Dotatate: an analysis of the NETTER-1 study
Complete response with combined BRAF and MEK inhibition in BRAF mutated advanced low-grade serous ovarian carcinoma.

Tholander, Bengt; Koliadi, Anthoula; Botling, Johan; Dahlstrand, Hanna et al.

Ingår i Upsala Journal of Medical Sciences, s. 325-329, 2020
- DOI för Complete response with combined BRAF and MEK inhibition in BRAF mutated advanced low-grade serous ovarian carcinoma.
A meta-analysis of the accuracy of a neuroendocrine tumor mRNA genomic biomarker (NETest) in blood

Öberg, Kjell; Califano, A.; Strosberg, J. R.; Ma, S. et al.

Ingår i Annals of Oncology, s. 202-212, 2020
- DOI för A meta-analysis of the accuracy of a neuroendocrine tumor mRNA genomic biomarker (NETest) in blood
Long-Term Safety Experience with Telotristat Ethyl Across Five Clinical Studies in Patients with Carcinoid Syndrome

Anthony, Lowell B.; Kulke, Matthew H.; Caplin, Martyn E.; Bergsland, Emily et al.

Ingår i The Oncologist, 2019
- DOI för Long-Term Safety Experience with Telotristat Ethyl Across Five Clinical Studies in Patients with Carcinoid Syndrome