BioMaterial Systems

Forskargruppen BMS leds av Prof. Cecilia Persson och utvecklar material och implantat för och genom additiv tillverkning.

Vi bedriver tvärvetenskaplig forskning med medlemmar från materialvetenskap, biomedicinsk teknik, maskinteknik, beräkningsvetenskap och biologi. Tillsammans utvecklar vi material och implantat för och genom additiv tillverkning.

Vår vision är att vara en samlingsplats för framstående forskare inom medicinsk teknik, särskilt de som strävar efter att koppla grundforskning till klinisk tillämpning, det vill säga att utveckla biomaterialet för det tänkta systemet.

Vårt uppdrag är att bidra med ny kunskap och bättre lösningar på medicinska problem, där biomaterialet eller implantatets utformning kan vara den förändring som behövs.

Här kan du se Cecilias pitch om BMS-gruppens forskningsverksamhet.

Vi är mycket tacksamma för anslag från våra bidragsgivare

Vetenskapsrådets logga

Research Focus

Forskargruppen BioMaterial Systems (BMS) fokuserar på att studera, utveckla och karakterisera nya material och implantatdesigner, främst för ortopediska tillämpningar. Fokus ligger på biomaterialutveckling för och genom additiv tillverkning (3D-printning). Numeriska och experimentella modeller används för att studera materialen samt interaktionen mellan implantat och vävnad. Tidiga biokompatibilitetsstudier kan utföras inom gruppen, medan vidare steg mot klinisk tillämpning och/eller kommersiell produkt sker i samarbete med exempelvis Akademiska sjukhuset i Uppsala.

BMS-gruppen bedriver tvärvetenskaplig forskning och arbetar inom följande kompetensområden:

Materialvetenskap
Beräkningsvetenskap
Biomekanik
Biologi

Forskningsprojekt

Gruppmedlemmar

Forskningsledare: Cecilia Persson

Gruppmedlemmar: Himesha Abenayake, Zaki Alomar, Belén Alonso Rancurel, Gaia Alyasin, Giulio Cavaliere, Francesco D´Elia, Niccoló De Berardinis, Linglu Hong, Gry Hulsart Billström, Cole Jetton, Stefan Johansson, Stephanie Kotiadis, Lisa Larsson, Vishal Mahey, Philip Procter, Farnaz Rezaei, Vitalii Shtender, Meaghi Sikder, Francesca Todescato, Ayush Sinha

Publikationer

3D-printed PLA/HA composite structures as synthetic trabecular bone: A feasibility study using fused deposition modeling

Wu, Dan; Spanou, Andrea; Diez-Escudero, Anna; Persson, Cecilia

Ingår i Journal of The Mechanical Behavior of Biomedical Materials, 2020
- DOI för 3D-printed PLA/HA composite structures as synthetic trabecular bone: A feasibility study using fused deposition modeling
A combined computational and experimental X-ray CT multiscale study of stable, slowly growing cracks in wood-fibre based composite materials

Joffre, Thomas; Segerholm, Kristoffer; Persson, Cecilia; Luengo Hendriks, Chris et al.

2016
A combined experimental and numerical method to estimate the elastic modulus of single trabeculae

Wu, Dan; Joffre, Thomas; Öhman, Caroline; Ferguson, Stephen et al.

Ingår i Journal of The Mechanical Behavior of Biomedical Materials, 2022
- DOI för A combined experimental and numerical method to estimate the elastic modulus of single trabeculae
A convolutional neural network-based method for the generation of super-resolution 3D models from clinical CT images

Zhou, Yijun; Klintström, Eva; Klintström, Benjamin; Ferguson, Stephen et al.

Ingår i Computer Methods and Programs in Biomedicine, 2024
- DOI för A convolutional neural network-based method for the generation of super-resolution 3D models from clinical CT images
- Ladda ner fulltext (pdf) av A convolutional neural network-based method for the generation of super-resolution 3D models from clinical CT images
A global digital volume correlation algorithm based on higher-order finite elements: Implementation and evaluation

van Dijk, Nico P.; Wu, Dan; Persson, Cecilia; Isaksson, Per

Ingår i International Journal of Solids and Structures, s. 211-227, 2019
- DOI för A global digital volume correlation algorithm based on higher-order finite elements: Implementation and evaluation
- Ladda ner fulltext (pdf) av A global digital volume correlation algorithm based on higher-order finite elements: Implementation and evaluation
A model for the biomechanical assessment of discoplasty in a laboratory setting

Ghandour, Salim; Lewin, Susanne; Pazarlis, Konstantinos A.; Isaksson, Per et al.

2021
A new bone adhesive candidate- does it work in human bone?: An ex-vivo preclinical evaluation in fresh human osteoporotic femoral head bone

Bojan, Alicja J.; Stadelmann, Vincent A.; Wu, Dan; Pujari-Palmer, Michael et al.

Ingår i Injury, s. 1858-1866, 2022
- DOI för A new bone adhesive candidate- does it work in human bone?: An ex-vivo preclinical evaluation in fresh human osteoporotic femoral head bone
- Ladda ner fulltext (pdf) av A new bone adhesive candidate- does it work in human bone?: An ex-vivo preclinical evaluation in fresh human osteoporotic femoral head bone
A non-drying porosity evaluation method for calcium phosphate cements

Ajaxon, Ingrid; Maazouz, Yassine; Ginebra, Maria-Pau; Öhman, Caroline et al.

Ingår i 26th Symposium and Annual Meeting of the International Society for Ceramics in Medicine, s. 68-68, 2014
A novel strategy to enhance interfacial adhesion in ﬁber-reinforced calcium phosphate cement

Gallinetti, Sara; Mestres, Gemma; Canal, Cristina; Persson, Cecilia et al.

Ingår i Journal of The Mechanical Behavior of Biomedical Materials, s. 495-503, 2017
- DOI för A novel strategy to enhance interfacial adhesion in ﬁber-reinforced calcium phosphate cement
- Ladda ner fulltext (pdf) av A novel strategy to enhance interfacial adhesion in ﬁber-reinforced calcium phosphate cement
A ready-to-use acidic, brushite-forming calcium phosphate cement

Luo, Jun; Engqvist, Håkan; Persson, Cecilia

Ingår i Acta Biomaterialia, s. 304-314, 2018
- DOI för A ready-to-use acidic, brushite-forming calcium phosphate cement
- Ladda ner fulltext (pdf) av A ready-to-use acidic, brushite-forming calcium phosphate cement
A ready-to-use acidic calcium phosphate cement

Luo, Jun; Engqvist, Håkan; Persson, Cecilia

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A review of the relationships between density and mechanical properties of vertebral trabecular bone

Öhman Mägi, Caroline; Holub, Ondrej; Hall, Richard M.; Persson, Cecilia

2017
A self-hardening biodegradable cement as a drug delivery vehicle

Mellgren, Torbjörn; Forsgren, Johan; Mihranyan, Albert; Engqvist, Håkan et al.

Ingår i European Cells & Materials, s. 51-51, 2012
- Ladda ner fulltext (pdf) av A self-hardening biodegradable cement as a drug delivery vehicle
A Topology Optimized Spinal Fusion Cage for the Use of Weak but Osteoinductive Bioceramics as Synthetic Bone Grafts

Ghandour, Salim; Bryant, Michael; M. Hall, Richard; Åberg, Jonas et al.

Ingår i Applied Materials Today, 2026
- DOI för A Topology Optimized Spinal Fusion Cage for the Use of Weak but Osteoinductive Bioceramics as Synthetic Bone Grafts
- Ladda ner fulltext (pdf) av A Topology Optimized Spinal Fusion Cage for the Use of Weak but Osteoinductive Bioceramics as Synthetic Bone Grafts
Acrylic bone cement modified with oligo (trimethylene carbonate)

López, Alejandro; Hoess, Andreas; Fathali, Hoda; Ott, Marjam et al.

Ingår i 5th Annual Meeting of the Scandinavian Society for Biomaterials, Uppsala Sweden, May 8-9, 2012, 2012
Additive manufacturing of biodegradable magnesium alloys

Larsson, Lisa; Nilsson Åhman, Hanna; D'Elia, Francesco; Maimaitiyili, Tuerdi et al.

2022
Additive manufacturing of magnesium alloy WE43 for biomedical applications

Larsson, Lisa; Nilsson Åhman, Hanna; D'Elia, Francesco; Persson, Cecilia

2025
Additively manufactured mesh-type titanium structures for cranial implants: E-PBF vs. L-PBF

Lewin, Susanne; Fleps, Ingmar; Åberg, Jonas; Ferguson, Stephen J. et al.

Ingår i Materials & design, 2021
- DOI för Additively manufactured mesh-type titanium structures for cranial implants: E-PBF vs. L-PBF
- Ladda ner fulltext (pdf) av Additively manufactured mesh-type titanium structures for cranial implants: E-PBF vs. L-PBF
Additively manufactured Piezoelectric Devices for Sustainable Energy Harvesting and Health Monitoring using PVDF-TrFE/rGO Electrodes

Spanou, Andrea; Resende Assis Silva, Rafael; Shtender, Vitalii; Almeida, Henrique M.V. et al.

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Additively manufactured WE43 for biodegradable urinary devices: Exploring the corrosion profile under in vitro urinary tract conditions

Pacheco, Margarida; D'Elia, Francesco; Nilsson Åhman, Hanna; Lima, Estêvão et al.

Ingår i Applied Materials Today, 2025
- DOI för Additively manufactured WE43 for biodegradable urinary devices: Exploring the corrosion profile under in vitro urinary tract conditions
- Ladda ner fulltext (pdf) av Additively manufactured WE43 for biodegradable urinary devices: Exploring the corrosion profile under in vitro urinary tract conditions
Adhesives from Inorganic Nanoparticles and Low-Molecular-Weight Organic Compounds

Yang, Jiaojiao; Luo, Jun; Persson, Cecilia; Welch, Ken et al.

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Advanced materials provide solutions towards a sustainable world

Hultman, Lars; Mazur, Sara; Ankarcrona, Caroline; Palmqvist, Anders et al.

Ingår i Nature Materials, s. 160-161, 2024
- DOI för Advanced materials provide solutions towards a sustainable world
An Enhanced Understanding of the Powder Bed Fusion-Laser Beam Processing of Mg-Y-3.9wt%-Nd-3wt%-Zr-0.5wt% (WE43) Alloy through Thermodynamic Modeling and Experimental Characterization

Nilsson Åhman, Hanna; Thorsson, Lena; Mellin, Pelle; Lindwall, Greta et al.

Ingår i Materials, 2022
- DOI för An Enhanced Understanding of the Powder Bed Fusion-Laser Beam Processing of Mg-Y-3.9wt%-Nd-3wt%-Zr-0.5wt% (WE43) Alloy through Thermodynamic Modeling and Experimental Characterization
- Ladda ner fulltext (pdf) av An Enhanced Understanding of the Powder Bed Fusion-Laser Beam Processing of Mg-Y-3.9wt%-Nd-3wt%-Zr-0.5wt% (WE43) Alloy through Thermodynamic Modeling and Experimental Characterization
An evaluation of methods to determine the porosity of calcium phosphate cements

Engstrand Unosson, Johanna; Persson, Cecilia; Engqvist, Håkan

Ingår i Journal of Biomedical Materials Research. Part B - Applied biomaterials, s. 62-71, 2015
- DOI för An evaluation of methods to determine the porosity of calcium phosphate cements
- Ladda ner fulltext (pdf) av An evaluation of methods to determine the porosity of calcium phosphate cements
An ex-vivo Biomechanical Assessment of Cement Discoplasty

Ghandour, Salim; Pazarlis, Konstantinos; Lewin, Susanne; Isaksson, Per et al.

2021
An ex-vivo model for the biomechanical assessment of cement discoplasty

Ghandour, Salim; Pazarlis, Konstantinos A.; Lewin, Susanne; Isaksson, Per et al.

Ingår i Frontiers in Bioengineering and Biotechnology, 2022
- DOI för An ex-vivo model for the biomechanical assessment of cement discoplasty
- Ladda ner fulltext (pdf) av An ex-vivo model for the biomechanical assessment of cement discoplasty
An improved trabecular bone model based on Voronoi tessellation

Zhou, Yijun; Isaksson, Per; Persson, Cecilia

Ingår i Journal of The Mechanical Behavior of Biomedical Materials, 2023
- DOI för An improved trabecular bone model based on Voronoi tessellation
- Ladda ner fulltext (pdf) av An improved trabecular bone model based on Voronoi tessellation
Analysis of the wear and tribofilm formation on silicon nitride for total hip joint replacement

Olofsson, Johanna; Grehk, Mikael; Persson, Cecilia; Jacobson, Staffan et al.

Ingår i Asiatrib 2010, 2010
Antibiofilm Properties of Linoleic Acid-loaded Bone Cement with and without Gentamicin

Hong, Linglu; Hjort, Karin; Persson, Cecilia; Andersson, Dan I.

Ingår i 33rd Annual Conference of the European Society for Biomaterials, s. 46-46, 2023
Antiviral Properties of Oxidized Silicon Nitride Against SARS-CoV-2

Katsaros, Ioannis; Ling, Jiaxin; Donzel-Gargand, Olivier; Akusjärvi, Göran et al.

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Application of phase-field fracture theories and digital volume correlation to synchrotron X-ray monitored fractures in human trabecular bone: A case study

Braesch-Andersen, Anna; Wu, Dan; Ferguson, Stephen J.; Persson, Cecilia et al.

Ingår i Journal of The Mechanical Behavior of Biomedical Materials, 2022
- DOI för Application of phase-field fracture theories and digital volume correlation to synchrotron X-ray monitored fractures in human trabecular bone: A case study
Assessing cement injection behaviour in cancellous bone: An in vitro study using flow models

Bou-Francis, Antony; Lopez, Alejandro; Persson, Cecilia; Hall, Richard M. et al.

Ingår i Journal of biomaterials applications, s. 582-594, 2014
- DOI för Assessing cement injection behaviour in cancellous bone: An in vitro study using flow models
Assessment of bone formation in CaP scaffolds – µCT method development

Lewin, Susanne; Barba, Albert; Persson, Cecilia; Franch, Jordi et al.

2017
Ball-on-disc testing of SiN_x coatings for hip joint implants

Pettersson, Maria; Olofsson, Johanna; Teuscher, Nico; Jacobson, Staffan et al.

2011
Bioactive hybrids based on polyhedral oligomeric silsesquioxane intended as bone fillers

López, Alejandro; Engstrand, Johanna; Engqvist, Håkan; Persson, Cecilia

Ingår i 9th World Biomaterials Congress, Chengdu China, June 1-5, 2012, 2012
Bioactive Silicon Nitride Implant Surfaces with Maintained Antibacterial Properties

Katsaros, Ioannis; Zhou, Yijun; Welch, Ken; Xia, Wei et al.

Ingår i Journal of Functional Biomaterials, 2022
- DOI för Bioactive Silicon Nitride Implant Surfaces with Maintained Antibacterial Properties
- Ladda ner fulltext (pdf) av Bioactive Silicon Nitride Implant Surfaces with Maintained Antibacterial Properties
Biocompatibility of a Zr-Based Metallic Glass Enabled by Additive Manufacturing

Larsson, Lisa; Marattukalam, Jithin James; Paschalidou, Eirini-Maria; Hjörvarsson, Björgvin et al.

Ingår i ACS Applied Bio Materials, s. 5741-5753, 2022
- DOI för Biocompatibility of a Zr-Based Metallic Glass Enabled by Additive Manufacturing
- Ladda ner fulltext (pdf) av Biocompatibility of a Zr-Based Metallic Glass Enabled by Additive Manufacturing
Biocompatibility of an additively manufactured zirconium-based bulk metallic glass: Effect of surface roughness on osteoblastic cell response

Marattukalam, JJ.; Larsson, L.; Hjörvarsson, Björgvin; Ferraz, Natalia et al.

Ingår i Swedish Arena for Metal Additive Manufacturing 2021., 2021
Biocompatibility of co-sputtered Si-Fe-C-N coatings

Skjöldebrand, Charlotte; Hulsart Billström, Gry; Engqvist, Håkan; Persson, Cecilia

2018
Biomechanics of low-modulus and standard acrylic bone cements in simulated vertebroplasty: A human ex vivo study

Holub, Ondrej; López, Alejandro; Borse, Vishal; Engqvist, Håkan et al.

Ingår i Journal of Biomechanics, s. 3258-3266, 2015
- DOI för Biomechanics of low-modulus and standard acrylic bone cements in simulated vertebroplasty: A human ex vivo study
- Ladda ner fulltext (pdf) av Biomechanics of low-modulus and standard acrylic bone cements in simulated vertebroplasty: A human ex vivo study
Bioresorbable, amorphous magnesium-fiber reinforced bone cement with enhanced mechanical and biological properties

Rich, Andrea M.; Berger, Leopold; Deller, Robin; de Berardinis, Niccoló et al.

Ingår i Biomaterials Advances, 2025
- DOI för Bioresorbable, amorphous magnesium-fiber reinforced bone cement with enhanced mechanical and biological properties
- Ladda ner fulltext (pdf) av Bioresorbable, amorphous magnesium-fiber reinforced bone cement with enhanced mechanical and biological properties
Brushite foamsthe effect of Tween (R) 80 and Pluronic (R) F-127 on foam porosity and mechanical properties

Unosson, Johanna; Montufar, Edgar B.; Engqvist, Håkan; Ginebra, Maria-Pau et al.

Ingår i Journal of Biomedical Materials Research. Part B - Applied biomaterials, s. 67-77, 2016
- DOI för Brushite foamsthe effect of Tween (R) 80 and Pluronic (R) F-127 on foam porosity and mechanical properties
- Ladda ner fulltext (pdf) av Brushite foamsthe effect of Tween (R) 80 and Pluronic (R) F-127 on foam porosity and mechanical properties
Calcium phosphate cements with strontium halides as radiopacifiers

López, Alejandro; Montazerolghaem, Maryam; Engqvist, Håkan; Ott, Marjam Karlsson et al.

Ingår i Journal of Biomedical Materials Research. Part B - Applied biomaterials, s. 250-259, 2014
- DOI för Calcium phosphate cements with strontium halides as radiopacifiers
Calcium phosphate sphere/PMMA composite: preparation, ion and drug release

Xia, Wei; Mujo, Martin; Engqvist, Håkan; Persson, Cecilia

Ingår i Scandinavian Society for Biomaterials (ScSB) Annual Meeting, 2012
Calcium phosphate spheres incorporated into PMMA cement for enhanced antibacterial properties

Qin, Tao; López, Alejandro; Öhman, Caroline; Engqvist, Håkan et al.

2014
CALPHAD description and FEM of AM Mg-based biodegradable alloys for biomedical applications

Alonso Rancurel, Belén; Cavaliere, Giulio; D'Elia, Francesco; Fisk, Martin et al.

2024
- Ladda ner fulltext (pdf) av CALPHAD description and FEM of AM Mg-based biodegradable alloys for biomedical applications
Can 3D-printed poly(L-lactic acid) be used as support structure for fullyresorbable ceramic cranial implants ?: A preliminary study

Grzeszczak, Ana; Åberg, Jonas; Persson, Cecilia

Ingår i Abstracts, s. 72-72, 2022
Can Cobalt(II) and Chromium(III) Ions Released from Joint Prostheses Influence the Friction Coefficient?

Hedberg, Yolanda; Pettersson, Maria; Pradhan, Sulena; Odnevall Wallinder, Inger et al.

Ingår i ACS Biomaterials Science & Engineering, s. 617-620, 2015
- DOI för Can Cobalt(II) and Chromium(III) Ions Released from Joint Prostheses Influence the Friction Coefficient?
- Ladda ner fulltext (pdf) av Can Cobalt(II) and Chromium(III) Ions Released from Joint Prostheses Influence the Friction Coefficient?
Ceramic cement as a potential stand-alone treatment for bone fractures: an in vitro study of ceramic-bone composites

Koh, Ilsoo; Gombert, Yvonne; Persson, Cecilia; Engqvist, Håkan et al.

Ingår i Journal of The Mechanical Behavior of Biomedical Materials, s. 519-529, 2016
- DOI för Ceramic cement as a potential stand-alone treatment for bone fractures: an in vitro study of ceramic-bone composites
Changes in the drug release pattern of fresh and set simvastatin-loaded brushite cement

Mestres, Gemma; Kugiejko, Karol; Pastorino, David; Unosson, Johanna et al.

Ingår i Materials science & engineering. C, biomimetic materials, sensors and systems, s. 88-96, 2016
- DOI för Changes in the drug release pattern of fresh and set simvastatin-loaded brushite cement
- Ladda ner fulltext (pdf) av Changes in the drug release pattern of fresh and set simvastatin-loaded brushite cement
Fler publikationer

Tillhör forskningsområden

Alumni

Philip Procter - Adjunct Professor
Morteza Aramesh - Affiliated Assistant Professor
Alexandra Davydova (Project Coordinator 2020-2024)
Estefanía Echeverri Correa (PhD student, 2024)
Yijun Zhou (PhD student, 2024)
Moyosore Fakoaya (MSc student, 2023)
Vendela Sandin (MSc student, 2023)
Satya Vaddamanu (research assistant, 2023)
Linglu Hong (research assistant, 2023)
Matilda Carlson (MSc student, 2023)
Satya Vaddamanu (MSc student, 2022)
Lotte Dijn (MSc student, 2022-2023)
Prakhar Dutta (MSc student, 2022-2023)
Carl Johan Hassila (research engineer, 2020-2022)
Margarida Pacheco (Exchange PhD student, 2021-2022)
Anna Braesch Andersen (Applied Mechanics) (PhD student, 2019-2022)
Zaki Alomar (Exchange PhD student, 2022)
Laura Del Mazo (Exchange PhD student, 2022)
Supradeepa Ganesan (MSc student, 2021-2022)
Leon Rothkranz (MSc student, 2021-2022)
Charlotte Skjöldebrand (PhD student, 2013-2022)
Clarence Wahman (MSc student, 2021)
Josephine Lantz (MSc student, 2021)
Cecilia Alsmark (project coordinator, until 2020)
Susan Peacock (project coordinator, until 2019)
Susanne Lewin (post-doc, 2020-2021)
Richard Hall (visiting Professor, 2018, 2019)
Anna Diez Escudero (post-doc, 2017-2019)
Gry Hulsart Billström (post-doc, 2016-2018)
Alejandro López (research engineer, 2018-2020)
Jenny Carlsson (Applied Mechanics) (PhD student, until 2020)
Luimar Correa Filho (PhD student, until 2020)
Dan Wu (PhD student, 2015-2019)
Elin Åkerlund (research assistant, 2019)
Charlotte Hopkinson (MSc student, 2019)
Rachel Stoakes (MSc student, 2019)
Yuling Liu (MSc student, 2019)
Jun Luo (PhD student, 2014-2018)
Christina Stelzl (research assistant, 2018)
Iain Christie (MSc student, 2018)
Léa Le Scouarnec (summer student, 2018)

Kontakt

Cecilia Persson