Mohanraj Ramachandran

Brain tumors induce immunoregulatory dendritic cells in draining lymph nodes that can be targeted by OX40 agonist treatment

Badillo-Godinez, Oscar; Niemi, Jenni; Helfridsson, Liam; Karimi, Shokoufeh et al.

Ingår i Journal for ImmunoTherapy of Cancer, 2025

• DOI för Brain tumors induce immunoregulatory dendritic cells in draining lymph nodes that can be targeted by OX40 agonist treatment
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Lack of ST2 aggravates glioma invasiveness, vascular abnormality, and immune suppression

Wicher, Grzegorz; Roy, Ananya; Vaccaro, Alessandra; Vemuri, Kalyani et al.

Ingår i Neuro-Oncology Advances, 2025

• DOI för Lack of ST2 aggravates glioma invasiveness, vascular abnormality, and immune suppression
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VLDLR mediates Semliki Forest virus neuroinvasion through the blood-cerebrospinal fluid barrier

Martikainen, Miika; Lugano, Roberta; Pietilä, Ilkka; Brosch, Sofie et al.

Ingår i Nature Communications, 2024

• DOI för VLDLR mediates Semliki Forest virus neuroinvasion through the blood-cerebrospinal fluid barrier
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Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma

Ramachandran, Mohanraj; Vaccaro, Alessandra; van de Walle, Tiarne; Georganaki, Maria et al.

Ingår i Cancer Cell, s. 1134-1151, 2023

• DOI för Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma
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Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients

Sarén, Tina; Ramachandran, Mohanraj; Gammelgård, Gustav; Lövgren, Tanja et al.

Ingår i Clinical Cancer Research, s. 4139-4152, 2023

• DOI för Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients
• Ladda ner fulltext (pdf) av Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients

Brain tumors induce immunoregulatory dendritic cells in draining lymph nodes that can be targeted by OX40 agonist treatment

Badillo-Godinez, Oscar; Niemi, Jenni; Helfridsson, Liam; Karimi, Shokoufeh et al.

Ingår i Journal for ImmunoTherapy of Cancer, 2025

• DOI för Brain tumors induce immunoregulatory dendritic cells in draining lymph nodes that can be targeted by OX40 agonist treatment
• Ladda ner fulltext (pdf) av Brain tumors induce immunoregulatory dendritic cells in draining lymph nodes that can be targeted by OX40 agonist treatment

Lack of ST2 aggravates glioma invasiveness, vascular abnormality, and immune suppression

Wicher, Grzegorz; Roy, Ananya; Vaccaro, Alessandra; Vemuri, Kalyani et al.

Ingår i Neuro-Oncology Advances, 2025

• DOI för Lack of ST2 aggravates glioma invasiveness, vascular abnormality, and immune suppression
• Ladda ner fulltext (pdf) av Lack of ST2 aggravates glioma invasiveness, vascular abnormality, and immune suppression

VLDLR mediates Semliki Forest virus neuroinvasion through the blood-cerebrospinal fluid barrier

Martikainen, Miika; Lugano, Roberta; Pietilä, Ilkka; Brosch, Sofie et al.

Ingår i Nature Communications, 2024

• DOI för VLDLR mediates Semliki Forest virus neuroinvasion through the blood-cerebrospinal fluid barrier
• Ladda ner fulltext (pdf) av VLDLR mediates Semliki Forest virus neuroinvasion through the blood-cerebrospinal fluid barrier

Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma

Ramachandran, Mohanraj; Vaccaro, Alessandra; van de Walle, Tiarne; Georganaki, Maria et al.

Ingår i Cancer Cell, s. 1134-1151, 2023

• DOI för Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma
• Ladda ner fulltext (pdf) av Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma

Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients

Sarén, Tina; Ramachandran, Mohanraj; Gammelgård, Gustav; Lövgren, Tanja et al.

Ingår i Clinical Cancer Research, s. 4139-4152, 2023

• DOI för Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients
• Ladda ner fulltext (pdf) av Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients

Complementarity-determining region clustering may cause CAR-T cell dysfunction

Sarén, Tina; Saronio, Giulia; Marti Torrell, Paula; Zhu, Xu et al.

Ingår i Nature Communications, 2023

• DOI för Complementarity-determining region clustering may cause CAR-T cell dysfunction
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Ixovex-1, a novel oncolytic E1B-mutated adenovirus

Anwar, Mohiemen; Arendt, Maja-Louise; Ramachandran, Mohanraj; Carlsson, Anette et al.

Ingår i Cancer Gene Therapy, s. 1628-1635, 2022

• DOI för Ixovex-1, a novel oncolytic E1B-mutated adenovirus
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CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers

Jin, Chuan; Ma, Jing; Ramachandran, Mohanraj; Yu, Di et al.

Ingår i Nature Biomedical Engineering, s. 830-841, 2022

• DOI för CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers
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Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma

van Hooren, Luuk; Vaccaro, Alessandra; Ramachandran, Mohanraj; Vazaios, Konstantinos et al.

Ingår i Nature Communications, 2021

• DOI för Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma
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ELTD1-deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma.

Huang, Hua; Georganaki, Maria; Conze, Lei Liu; Laviña, Bàrbara et al.

Ingår i Neuro-Oncology, s. 398-411, 2021

• DOI för ELTD1-deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma.
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Concurrent expression of HP-NAP enhances antitumor efficacy of oncolytic vaccinia virus but not for Semliki Forest virus

Ma, Jing; Jin, Chuan; Čančer, Matko; Wang, Hai et al.

Ingår i MOLECULAR THERAPY-ONCOLYTICS, s. 356-366, 2021

• DOI för Concurrent expression of HP-NAP enhances antitumor efficacy of oncolytic vaccinia virus but not for Semliki Forest virus
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IFN-I-tolerant oncolytic Semliki Forest virus in combination with anti-PD1 enhances T cell response against mouse glioma

Martikainen, Miika; Ramachandran, Mohanraj; Lugano, Roberta; Ma, Jing et al.

Ingår i MOLECULAR THERAPY-ONCOLYTICS, s. 37-46, 2021

• DOI för IFN-I-tolerant oncolytic Semliki Forest virus in combination with anti-PD1 enhances T cell response against mouse glioma
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Characterization of virus-mediated immunogenic cancer cell death and the consequences for oncolytic virus-based immunotherapy of cancer

Ma, Jing; Ramachandran, Mohanraj; Jin, Chuan; Quijano-Rubio, Clara et al.

Ingår i Cell Death and Disease, 2020

• DOI för Characterization of virus-mediated immunogenic cancer cell death and the consequences for oncolytic virus-based immunotherapy of cancer
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Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy

Georganaki, Maria; Ramachandran, Mohanraj; Tuit, Sander; Nunez, Nicolas Gonzalo et al.

Ingår i Oncoimmunology, 2020

• DOI för Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy
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Pro-inflammatory allogeneic DCs promote activation of bystander immune cells and thereby license antigen-specific T-cell responses

Fotaki, Grammatiki; Jin, Chuan; Ramachandran, Mohanraj; Kerzeli, Iliana Kyriaki et al.

Ingår i Oncoimmunology, 2018

• DOI för Pro-inflammatory allogeneic DCs promote activation of bystander immune cells and thereby license antigen-specific T-cell responses

Cancer vaccine based on a combination of an infection-enhanced adenoviral vector and pro-inflammatory allogeneic DCs leads to sustained antigen-specific immune responses in three melanoma models

Fotaki, Grammatiki; Jin, Chuan; Kerzeli, Iliana Kyriaki; Ramachandran, Mohanraj et al.

Ingår i Oncoimmunology, 2018

• DOI för Cancer vaccine based on a combination of an infection-enhanced adenoviral vector and pro-inflammatory allogeneic DCs leads to sustained antigen-specific immune responses in three melanoma models
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Safe and effective treatment of experimental neuroblastoma and glioblastoma using systemically administered triple microRNA-detargeted oncolytic Semliki Forest virus

Ramachandran, Mohanraj; Yu, Di; Dyczynski, Matheus; Baskaran, Sathishkumar et al.

Ingår i Clinical Cancer Research, s. 1519-1530, 2017

• DOI för Safe and effective treatment of experimental neuroblastoma and glioblastoma using systemically administered triple microRNA-detargeted oncolytic Semliki Forest virus

Adenovirus, Semliki Forest virus and vaccinia virus-induced immunogenic cell death augments oncolytic virus immunotherapy

Ma, Jing; Ramachandran, Mohanraj; Jin, Chuan; Essand, Magnus et al.

Ingår i Scandinavian Journal of Immunology, s. 341-341, 2017

Insertion of the Type-I IFN Decoy Receptor B18R in a miRNA-Tagged Semliki Forest Virus Improves Oncolytic Capacity but Results in Neurotoxicity

Sarén, Tina; Ramachandran, Mohanraj; Martikainen, Miika; Yu, Di

Ingår i MOLECULAR THERAPY-ONCOLYTICS, s. 67-75, 2017

• DOI för Insertion of the Type-I IFN Decoy Receptor B18R in a miRNA-Tagged Semliki Forest Virus Improves Oncolytic Capacity but Results in Neurotoxicity
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CAR T-Cells with Induced Secretion of Helicobacter Pylori Neutrophil-Activating Protein (HP-NAP) Yields Improved Anti-Tumor Activity and Reduced Immunosuppression

Essand, Magnus; Ma, Jing; Jin, Chuan; Ramachandran, Mohanraj et al.

Ingår i Molecular Therapy, s. 288-288, 2017

Long-term episomal gene transfer for safe engineering of T cells for adoptive cell therapy of cancer

Jin, Chuan; Ramachandran, Mohanraj; Fotaki, Grammatiki; Nilsson, Berith et al.

Ingår i CANCER IMMUNOLOGY RESEARCH, 2016

• DOI för Long-term episomal gene transfer for safe engineering of T cells for adoptive cell therapy of cancer

Safe engineering of CAR T cells for adoptive cell therapy of cancer using long-term episomal gene transfer

Jin, Chuan; Fotaki, Grammatiki; Ramachandran, Mohanraj; Nilsson, Berith et al.

Ingår i EMBO Molecular Medicine, s. 702-711, 2016

• DOI för Safe engineering of CAR T cells for adoptive cell therapy of cancer using long-term episomal gene transfer
• Ladda ner fulltext (pdf) av Safe engineering of CAR T cells for adoptive cell therapy of cancer using long-term episomal gene transfer

Long-term episomal gene transfer for safe engineering of T-cells for adoptive cell therapy of cancer

Jin, Chuan; Ramachandran, Mohanraj; Fotaki, Grammatiki; Nilsson, Bo et al.

Ingår i Human Gene Therapy, 2014

Systemic treatment with CAR-engineered T cells against PSCA delays subcutaneous tumor growth and prolongs survival of mice

Hillerdal, Victoria; Ramachandran, Mohanraj; Leja, Justyna; Essand, Magnus

Ingår i BMC Cancer, s. 30, 2014

• DOI för Systemic treatment with CAR-engineered T cells against PSCA delays subcutaneous tumor growth and prolongs survival of mice
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Adenovirus Encoded Helicobacter pylori Neutrophil Activating Protein Promotes Maturation of DCs with Th-1 Polarization, Improved Antigen Presentation and Migration

Ramachandran, Mohanraj; Jin, Chuan; Yu, Di; Eriksson, Fredrik et al.

Ingår i Molecular Therapy, 2014

Vector-Encoded Helicobacter pylori Neutrophil-Activating Protein Promotes Maturation of Dendritic Cells with Th1 Polarization and Improved Migration

Ramachandran, Mohanraj; Jin, Chuan; Yu, Di; Eriksson, Fredrik et al.

Ingår i Journal of Immunology, s. 2287-2296, 2014

• DOI för Vector-Encoded Helicobacter pylori Neutrophil-Activating Protein Promotes Maturation of Dendritic Cells with Th1 Polarization and Improved Migration

An infection-enhanced oncolytic adenovirus secreting H. pylori neutrophil-activating protein with therapeutic effects on neuroendocrine tumors

Ramachandran, Mohanraj; Yu, Di; Wanders, Alkwin; Essand, Magnus et al.

Ingår i Molecular Therapy, s. 2008-2018, 2013

• DOI för An infection-enhanced oncolytic adenovirus secreting H. pylori neutrophil-activating protein with therapeutic effects on neuroendocrine tumors
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Adenovirus Serotype 5 Vectors with Tat-PTD Modified Hexon and Serotype 35 Fiber Show Greatly Enhanced Transduction Capacity of Primary Cell Cultures

Yu, Di; Jin, Chuan; Ramachandran, Mohanraj; Xu, Jing et al.

Ingår i PLOS ONE, 2013

• DOI för Adenovirus Serotype 5 Vectors with Tat-PTD Modified Hexon and Serotype 35 Fiber Show Greatly Enhanced Transduction Capacity of Primary Cell Cultures
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Of mice and lymphoid aggregates: modeling tertiary lymphoid structures in cancer

Vaccaro, Alessandra; van de Walle, Tiarne; Ramachandran, Mohanraj; Essand, Magnus et al.

Ingår i Frontiers in Immunology, 2023

• DOI för Of mice and lymphoid aggregates: modeling tertiary lymphoid structures in cancer
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Tertiary Lymphoid Structures in the Central Nervous System: Implications for Glioblastoma

van de Walle, Tiarne; Vaccaro, Alessandra; Ramachandran, Mohanraj; Pietilä, Ilkka et al.

Ingår i Frontiers in Immunology, 2021

• DOI för Tertiary Lymphoid Structures in the Central Nervous System: Implications for Glioblastoma
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Tumor angiogenesis: causes, consequences, challenges and opportunities

Lugano, Roberta; Ramachandran, Mohanraj; Dimberg, Anna

Ingår i Cellular and Molecular Life Sciences (CMLS), s. 1745-1770, 2020

• DOI för Tumor angiogenesis: causes, consequences, challenges and opportunities
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The cancer-immunity cycle as rational design for synthetic cancer drugs: Novel DC vaccines and CAR T-cells

Ramachandran, Mohanraj; Dimberg, Anna; Essand, Magnus

Ingår i Seminars in Cancer Biology, s. 23-35, 2017

• DOI för The cancer-immunity cycle as rational design for synthetic cancer drugs: Novel DC vaccines and CAR T-cells
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Cancer Immunotherapy: Evolving Oncolytic viruses and CAR T-cells

Ramachandran, Mohanraj

2016

• Ladda ner fulltext (pdf) av Cancer Immunotherapy: Evolving Oncolytic viruses and CAR T-cells

Tumor antigen-loaded allogeneic dendritic cells augment therapeutic effect of adoptively transferred T-cells by altering tumor immune-microenvironment

Fotaki, Grammatiki; Jin, Chuan; Kerzeli, Iliana Kyriaki; Ramachandran, Mohanraj et al.

CD19 CAR T-cells with induced secretion of Helicobacter Pylori Neutrophil-Activating Protein (HP-NAP) yields improved anti-tumor activity and reduced immunosuppression

Jin, Chuan; Ma, Jing; Ramachandran, Mohanraj; Yu, Di et al.

Single-cell RNA analysis reveal subpopulations of CAR T cells correlating with response in lymphoma patients

Sarén, Tina; Ramachandran, Mohanraj; Gammelgård, Gustav; Lövgren, Tanja et al.

Armed CAR-T cells directed against IL13Rα2 show potent activity against glioblastoma

Sarén, Tina; Ramachandran, Mohanraj; Saronio, Giulia; Thelander, Josefin et al.

Complementary-determining region clustering causes CAR-T cell dysfunction

Sarén, Tina; Saronio, Giulia; Zhu, Xu; Thelander, Josefin et al.

CRISPR/Cas9 as a tool to disrupt wild-type and A53T SNCA in sporadic and familial Parkinson’s disease

Molisak, Agnieszka; Konstantinidis, Evangelos; Aguilar, Ximena; Giedraitis, Vilmantas et al.