Oscar Verho
Universitetslektor vid Institutionen för läkemedelskemi; Läkemedelsdesign och läkemedelsutveckling
- E-post:
- oscar.verho@ilk.uu.se
- Besöksadress:
- Biomedicinskt Centrum BMC, Husargatan 3
- Postadress:
- Box 574
751 23 UPPSALA
- CV:
- Ladda ned CV
Kort presentation
Oscar Verho disputerade 2014 under handledning av Prof. Jan-Erling Bäckvall och blev universitetslektor vid Institutionen för Läkemedelskemi 2022. Hans forskning fokuserar på utformningen av nya syntetiska metoder som kan underlätta syntesen av bioaktiva molekyler och stödja forskning inom kemisk biologi och läkemedelsutveckling. Detta inkluderar forskning både fokuserat på nya elektrokatalyserade C-H funktionaliseringsmetoder och DNA-kodade bibliotek.
Nyckelord
- organic synthesis
- electrochemistry
- drug discovery
- c-h functionalization
- dna-encoded libraries
Forskning
Currently, my group focuses on the design of new synthetic methodologies that can be used for the synthesis of biologically active compounds and small molecule libraries. Here, much of our recent research has been centered on 8-aminoquinoline directed C-H functionalization, as it constitutes a very powerful strategy for rapidly building up molecular complexity. My group is also fascinated by new techniques that can enable expedient synthesis and screening of compound libraries for drug discovery applications. Here, we are currently collaborating with the SciLifeLab in the design of different DNA encoded compound libraries.
Publikationer
Senaste publikationer
Regioselective Palladaelectro-Catalyzed Chlorination of Arenes in an Undivided Cell
Ingår i Advanced Synthesis and Catalysis, 2025
- DOI för Regioselective Palladaelectro-Catalyzed Chlorination of Arenes in an Undivided Cell
- Ladda ner fulltext (pdf) av Regioselective Palladaelectro-Catalyzed Chlorination of Arenes in an Undivided Cell
Carboxylate and coordination influence on the formation of an active RuV Oxo species
Ingår i Scientific Reports, 2025
- DOI för Carboxylate and coordination influence on the formation of an active RuV Oxo species
- Ladda ner fulltext (pdf) av Carboxylate and coordination influence on the formation of an active RuV Oxo species
Ingår i Antimicrobial Agents and Chemotherapy, s. 1-18, 2024
- DOI för Identification of novel and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries
- Ladda ner fulltext (pdf) av Identification of novel and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries
Ingår i Frontiers in Chemistry, 2024
- DOI för Co-complexes on modified graphite surface for steady green hydrogen production from water at neutral pH
- Ladda ner fulltext (pdf) av Co-complexes on modified graphite surface for steady green hydrogen production from water at neutral pH
Bifunctional and regenerable molecular electrode for water electrolysis at neutral pH
Ingår i Journal of Materials Chemistry A, s. 13331-13340, 2023
- DOI för Bifunctional and regenerable molecular electrode for water electrolysis at neutral pH
- Ladda ner fulltext (pdf) av Bifunctional and regenerable molecular electrode for water electrolysis at neutral pH
Alla publikationer
Artiklar i tidskrift
Regioselective Palladaelectro-Catalyzed Chlorination of Arenes in an Undivided Cell
Ingår i Advanced Synthesis and Catalysis, 2025
- DOI för Regioselective Palladaelectro-Catalyzed Chlorination of Arenes in an Undivided Cell
- Ladda ner fulltext (pdf) av Regioselective Palladaelectro-Catalyzed Chlorination of Arenes in an Undivided Cell
Carboxylate and coordination influence on the formation of an active RuV Oxo species
Ingår i Scientific Reports, 2025
- DOI för Carboxylate and coordination influence on the formation of an active RuV Oxo species
- Ladda ner fulltext (pdf) av Carboxylate and coordination influence on the formation of an active RuV Oxo species
Ingår i Antimicrobial Agents and Chemotherapy, s. 1-18, 2024
- DOI för Identification of novel and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries
- Ladda ner fulltext (pdf) av Identification of novel and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries
Ingår i Frontiers in Chemistry, 2024
- DOI för Co-complexes on modified graphite surface for steady green hydrogen production from water at neutral pH
- Ladda ner fulltext (pdf) av Co-complexes on modified graphite surface for steady green hydrogen production from water at neutral pH
Bifunctional and regenerable molecular electrode for water electrolysis at neutral pH
Ingår i Journal of Materials Chemistry A, s. 13331-13340, 2023
- DOI för Bifunctional and regenerable molecular electrode for water electrolysis at neutral pH
- Ladda ner fulltext (pdf) av Bifunctional and regenerable molecular electrode for water electrolysis at neutral pH
Electrochemical Palladium-Catalyzed Oxidative Carbonylation-Cyclization of Enallenols
Ingår i Angewandte Chemie International Edition, 2022
- DOI för Electrochemical Palladium-Catalyzed Oxidative Carbonylation-Cyclization of Enallenols
- Ladda ner fulltext (pdf) av Electrochemical Palladium-Catalyzed Oxidative Carbonylation-Cyclization of Enallenols
Ingår i ChemCatChem, 2022
Ingår i ACS Catalysis, s. 2999-3008, 2021
- DOI för Investigation of the Deactivation and Reactivation Mechanism of a Heterogeneous Palladium(II) Catalyst in the Cycloisomerization of Acetylenic Acids by In Situ XAS
- Ladda ner fulltext (pdf) av Investigation of the Deactivation and Reactivation Mechanism of a Heterogeneous Palladium(II) Catalyst in the Cycloisomerization of Acetylenic Acids by In Situ XAS
Ingår i Journal of Organic Chemistry, s. 8527-8537, 2021
- DOI för A Study of an 8-Aminoquinoline-Directed C(sp(2))-H Arylation Reaction on the Route to Chiral Cyclobutane Keto Acids from Myrtenal
- Ladda ner fulltext (pdf) av A Study of an 8-Aminoquinoline-Directed C(sp(2))-H Arylation Reaction on the Route to Chiral Cyclobutane Keto Acids from Myrtenal
Artiklar, forskningsöversikt
The Impact of Ligand Carboxylates on Electrocatalyzed Water Oxidation
Ingår i Accounts of Chemical Research, s. 3326-3337, 2021
- DOI för The Impact of Ligand Carboxylates on Electrocatalyzed Water Oxidation
- Ladda ner fulltext (pdf) av The Impact of Ligand Carboxylates on Electrocatalyzed Water Oxidation
Kapitel i böcker, delar av antologi
Ingår i Nanoparticles in catalysis, s. 243-278, Springer Nature, 2020