Elisabet Nielsen
Professor vid Institutionen för farmaci; Klinisk farmaci och farmakoterapi
- Telefon:
- 018-471 42 27
- E-post:
- elisabet.nielsen@uu.se
- Besöksadress:
- Biomedicinskt Centrum BMC, Husargatan 3
- Postadress:
- Box 580
751 23 UPPSALA
Professor vid Institutionen för farmaci; Klinisk farmaci och farmakoterapi
- E-post:
- elisabet.nielsen@uu.se
- Besöksadress:
- Biomedicinskt Centrum BMC, Husargatan 3
- Postadress:
- Box 580
751 23 UPPSALA
Kort presentation
Elisabet Nielsen is a Professor in Clinical Pharmacy at the Department of Pharmacy, Uppsala University, Sweden. Elisabet graduated in 1998 with a MSc in Pharmaceutical Sciences, and in 2011 she received her PhD. Her research focus on developing, implementing and evaluating methods for individualized drug treatments in various therapeutic areas and patient populations.
Nyckelord
- clinical pharmacy
- therapeutic drug monitoring
- clinical research
- dose individualization
- bacterial infections
- clinical trials
- drug treatment optimization
- copd

Publikationer
Urval av publikationer
Ingår i International Journal of Clinical Pharmacy, s. 178-186, 2025
- DOI för Model-informed precision dosing of vancomycin in clinical practice: an intervention development study
- Ladda ner fulltext (pdf) av Model-informed precision dosing of vancomycin in clinical practice: an intervention development study
Ingår i Cytokine, 2023
- DOI för Predicting cytokine kinetics during sepsis; a modelling framework from a porcine sepsis model with live Escherichia coli
- Ladda ner fulltext (pdf) av Predicting cytokine kinetics during sepsis; a modelling framework from a porcine sepsis model with live Escherichia coli
Research priorities towards precision antibiotic therapy to improve patient care
Ingår i LANCET MICROBE, 2022
- DOI för Research priorities towards precision antibiotic therapy to improve patient care
- Ladda ner fulltext (pdf) av Research priorities towards precision antibiotic therapy to improve patient care
Ingår i Journal of Antimicrobial Chemotherapy, s. 400-408, 2020
Pharmacokinetic-Pharmacodynamic Modeling of Antibacterial Drugs
Ingår i Pharmacological Reviews, s. 1053-1090, 2013
Ingår i Antimicrobial Agents and Chemotherapy, s. 128-136, 2007
Senaste publikationer
Ingår i Journal of Antimicrobial Chemotherapy, s. 876-884, 2025
- DOI för Short, extended and continuous infusion of β-lactams: predicted impact on target attainment and risk for toxicity in an ICU patient cohort
- Ladda ner fulltext (pdf) av Short, extended and continuous infusion of β-lactams: predicted impact on target attainment and risk for toxicity in an ICU patient cohort
Ingår i Scientific Reports, 2025
- DOI för Utilizing gentamicin concentrations to estimate glomerular filtration rate in intensive care unit patients
- Ladda ner fulltext (pdf) av Utilizing gentamicin concentrations to estimate glomerular filtration rate in intensive care unit patients
First dose target attainment with extended infusion regimens of piperacillin and meropenem
Ingår i Critical Care, 2025
- DOI för First dose target attainment with extended infusion regimens of piperacillin and meropenem
- Ladda ner fulltext (pdf) av First dose target attainment with extended infusion regimens of piperacillin and meropenem
Ingår i JAC - Antimicrobial Resistance, 2025
- DOI för A model-based evaluation of the pharmacokinetics-pharmacodynamics (PKPD) of avibactam in combination with ceftazidime
- Ladda ner fulltext (pdf) av A model-based evaluation of the pharmacokinetics-pharmacodynamics (PKPD) of avibactam in combination with ceftazidime
Ingår i International Journal of Antimicrobial Agents, 2025
- DOI för An integrative and translational PKPD modelling approach to explore the combined effect of polymyxin B and minocycline against Klebsiella pneumoniae
- Ladda ner fulltext (pdf) av An integrative and translational PKPD modelling approach to explore the combined effect of polymyxin B and minocycline against Klebsiella pneumoniae
Alla publikationer
Artiklar i tidskrift
Ingår i Journal of Antimicrobial Chemotherapy, s. 876-884, 2025
- DOI för Short, extended and continuous infusion of β-lactams: predicted impact on target attainment and risk for toxicity in an ICU patient cohort
- Ladda ner fulltext (pdf) av Short, extended and continuous infusion of β-lactams: predicted impact on target attainment and risk for toxicity in an ICU patient cohort
Ingår i Scientific Reports, 2025
- DOI för Utilizing gentamicin concentrations to estimate glomerular filtration rate in intensive care unit patients
- Ladda ner fulltext (pdf) av Utilizing gentamicin concentrations to estimate glomerular filtration rate in intensive care unit patients
First dose target attainment with extended infusion regimens of piperacillin and meropenem
Ingår i Critical Care, 2025
- DOI för First dose target attainment with extended infusion regimens of piperacillin and meropenem
- Ladda ner fulltext (pdf) av First dose target attainment with extended infusion regimens of piperacillin and meropenem
Ingår i JAC - Antimicrobial Resistance, 2025
- DOI för A model-based evaluation of the pharmacokinetics-pharmacodynamics (PKPD) of avibactam in combination with ceftazidime
- Ladda ner fulltext (pdf) av A model-based evaluation of the pharmacokinetics-pharmacodynamics (PKPD) of avibactam in combination with ceftazidime
Ingår i International Journal of Antimicrobial Agents, 2025
- DOI för An integrative and translational PKPD modelling approach to explore the combined effect of polymyxin B and minocycline against Klebsiella pneumoniae
- Ladda ner fulltext (pdf) av An integrative and translational PKPD modelling approach to explore the combined effect of polymyxin B and minocycline against Klebsiella pneumoniae
Ingår i International Journal of Clinical Pharmacy, s. 178-186, 2025
- DOI för Model-informed precision dosing of vancomycin in clinical practice: an intervention development study
- Ladda ner fulltext (pdf) av Model-informed precision dosing of vancomycin in clinical practice: an intervention development study
Plasma effects on bacterial time-kill dynamics: Insights from a PK/PD modelling analysis
Ingår i International Journal of Antimicrobial Agents, 2025
- DOI för Plasma effects on bacterial time-kill dynamics: Insights from a PK/PD modelling analysis
- Ladda ner fulltext (pdf) av Plasma effects on bacterial time-kill dynamics: Insights from a PK/PD modelling analysis
Ingår i International Journal of Antimicrobial Agents, 2025
- DOI för Ceftazidime-avibactam (CAZ-AVI) pharmacokinetics in critically ill patients undergoing continuous venovenous hemodiafiltration (CVVHDF)
- Ladda ner fulltext (pdf) av Ceftazidime-avibactam (CAZ-AVI) pharmacokinetics in critically ill patients undergoing continuous venovenous hemodiafiltration (CVVHDF)
Ingår i Journal of Antimicrobial Chemotherapy, s. 3150-3159, 2024
- DOI för Model-based translation of results from in vitro to in vivo experiments for afabicin activity against Staphylococcus aureus
- Ladda ner fulltext (pdf) av Model-based translation of results from in vitro to in vivo experiments for afabicin activity against Staphylococcus aureus
Ingår i Health Expectations, 2024
- DOI för 'You're Just Thinking About Going Home': Exploring Person-Centred Medication Communication With Older Patients at Hospital Discharge
- Ladda ner fulltext (pdf) av 'You're Just Thinking About Going Home': Exploring Person-Centred Medication Communication With Older Patients at Hospital Discharge
Ingår i International Journal of Antimicrobial Agents, 2024
- DOI för Physiologically-based pharmacokinetic modelling in sepsis: A tool to elucidate how pathophysiology affects meropenem pharmacokinetics
- Ladda ner fulltext (pdf) av Physiologically-based pharmacokinetic modelling in sepsis: A tool to elucidate how pathophysiology affects meropenem pharmacokinetics
Ingår i Journal of Antimicrobial Chemotherapy, 2024
- DOI för Therapeutic drug monitoring (TDM) of β-lactam/β-lactamase inhibitor (BL/BLI) drug combinations: insights from a pharmacometric simulation study
- Ladda ner fulltext (pdf) av Therapeutic drug monitoring (TDM) of β-lactam/β-lactamase inhibitor (BL/BLI) drug combinations: insights from a pharmacometric simulation study
Ingår i Basic & Clinical Pharmacology & Toxicology, s. 556-560, 2024
- DOI för Therapeutic drug monitoring of monoclonal antibodies in chronic inflammatory diseases: A snapshot of laboratories and applications across Europe
- Ladda ner fulltext (pdf) av Therapeutic drug monitoring of monoclonal antibodies in chronic inflammatory diseases: A snapshot of laboratories and applications across Europe
Ingår i International Journal of Antimicrobial Agents, 2024
- DOI för PK/PD modelling and simulation of longitudinal meropenem in vivo effects against Escherichia coli and Klebsiella pneumoniae strains with high MICs
- Ladda ner fulltext (pdf) av PK/PD modelling and simulation of longitudinal meropenem in vivo effects against Escherichia coli and Klebsiella pneumoniae strains with high MICs
Ingår i Basic & Clinical Pharmacology & Toxicology, 2024
- DOI för Population pharmacokinetic modelling of cetirizine concentrations in human breast milk: A contribution from the ConcePTION project
- Ladda ner fulltext (pdf) av Population pharmacokinetic modelling of cetirizine concentrations in human breast milk: A contribution from the ConcePTION project
Ingår i Upsala Journal of Medical Sciences, 2024
- DOI för Recommended dosages of analgesic and sedative drugs in intensive care result in a low incidence of potentially toxic blood concentrations
- Ladda ner fulltext (pdf) av Recommended dosages of analgesic and sedative drugs in intensive care result in a low incidence of potentially toxic blood concentrations
Ingår i Scientific Reports, 2024
- DOI för Quantifying combined effects of colistin and ciprofloxacin against Escherichia coli in an in silico pharmacokinetic-pharmacodynamic model
- Ladda ner fulltext (pdf) av Quantifying combined effects of colistin and ciprofloxacin against Escherichia coli in an in silico pharmacokinetic-pharmacodynamic model
Ingår i Infectious Diseases, s. 451-459, 2024
- DOI för Estimated glomerular filtration rate as a tool for early identification of patients with insufficient exposure to beta-lactam antibiotics in intensive care units
- Ladda ner fulltext (pdf) av Estimated glomerular filtration rate as a tool for early identification of patients with insufficient exposure to beta-lactam antibiotics in intensive care units
Ingår i Research in Social and Administrative Pharmacy, s. 216-217, 2024
Ingår i BMC Health Services Research, 2023
- DOI för The complexities of communication at hospital discharge of older patients: a qualitative study of healthcare professionals' views
- Ladda ner fulltext (pdf) av The complexities of communication at hospital discharge of older patients: a qualitative study of healthcare professionals' views
Ingår i Cytokine, 2023
- DOI för Predicting cytokine kinetics during sepsis; a modelling framework from a porcine sepsis model with live Escherichia coli
- Ladda ner fulltext (pdf) av Predicting cytokine kinetics during sepsis; a modelling framework from a porcine sepsis model with live Escherichia coli
Ingår i International Journal of Antimicrobial Agents, 2023
- DOI för Therapeutic drug monitoring of vancomycin and meropenem: Illustration of the impact of inaccurate information in dose administration time
- Ladda ner fulltext (pdf) av Therapeutic drug monitoring of vancomycin and meropenem: Illustration of the impact of inaccurate information in dose administration time
Ingår i Journal of Antimicrobial Chemotherapy, 2023
- DOI för Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time-kill experiments: high agreement with in silico predictions
- Ladda ner fulltext (pdf) av Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time-kill experiments: high agreement with in silico predictions
Ingår i CPT, s. 1972-1987, 2023
- DOI för Model‐based assessment of neutrophil‐mediated phagocytosis and digestion of bacteria across in vitro and in vivo studies
- Ladda ner fulltext (pdf) av Model‐based assessment of neutrophil‐mediated phagocytosis and digestion of bacteria across in vitro and in vivo studies
Ingår i Journal of Antimicrobial Chemotherapy, 2023
Ingår i British Journal of Clinical Pharmacology, s. 1575-1587, 2023
- DOI för Risk factors for and preventability of drug‐related hospital revisits in older patients: A post‐hoc analysis of a randomized clinical trial
- Ladda ner fulltext (pdf) av Risk factors for and preventability of drug‐related hospital revisits in older patients: A post‐hoc analysis of a randomized clinical trial
Population pharmacokinetics of cefotaxime in intensive care patients
Ingår i European Journal of Clinical Pharmacology, s. 251-258, 2022
- DOI för Population pharmacokinetics of cefotaxime in intensive care patients
- Ladda ner fulltext (pdf) av Population pharmacokinetics of cefotaxime in intensive care patients
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors
Ingår i Nature Chemistry, s. 15-24, 2022
Research priorities towards precision antibiotic therapy to improve patient care
Ingår i LANCET MICROBE, 2022
- DOI för Research priorities towards precision antibiotic therapy to improve patient care
- Ladda ner fulltext (pdf) av Research priorities towards precision antibiotic therapy to improve patient care
Ingår i Respiratory Medicine, 2022
- DOI för Changes in critical inhaler technique errors in inhaled COPD treatment: A one-year follow-up study in Sweden
- Ladda ner fulltext (pdf) av Changes in critical inhaler technique errors in inhaled COPD treatment: A one-year follow-up study in Sweden
Ingår i JAMA Network Open, 2021
- DOI för Effects of Hospital-Based Comprehensive Medication Reviews Including Postdischarge Follow-up on Older Patients' Use of Health Care: A Cluster Randomized Clinical Trial
- Ladda ner fulltext (pdf) av Effects of Hospital-Based Comprehensive Medication Reviews Including Postdischarge Follow-up on Older Patients' Use of Health Care: A Cluster Randomized Clinical Trial
Ingår i TOXICOLOGIE ANALYTIQUE ET CLINIQUE, s. 327-337, 2021
Ingår i npj Primary Care Respiratory Medicine, 2021
- DOI för Critical inhaler technique errors in Swedish patients with COPD: a cross-sectional study analysing video-recorded demonstrations
- Ladda ner fulltext (pdf) av Critical inhaler technique errors in Swedish patients with COPD: a cross-sectional study analysing video-recorded demonstrations
Ingår i Cancer Reports, 2021
- DOI för Continuous infusion of piperacillin‐tazobactam significantly improves target attainment in children with cancer and fever
- Ladda ner fulltext (pdf) av Continuous infusion of piperacillin‐tazobactam significantly improves target attainment in children with cancer and fever
Ingår i Journal of Clinical Pharmacy and Therapeutics, s. 1021-1029, 2020
- DOI för Intervention fidelity and process outcomes of medication reviews including post-discharge follow-up in older hospitalized patients: Process evaluation of the MedBridge trial.
- Ladda ner fulltext (pdf) av Intervention fidelity and process outcomes of medication reviews including post-discharge follow-up in older hospitalized patients: Process evaluation of the MedBridge trial.
Ingår i International Journal of Antimicrobial Agents, 2020
- DOI för Combination of polymyxin B and minocycline against multidrug-resistant Klebsiella pneumoniae: interaction quantified by pharmacokinetic/pharmacodynamic modelling from in vitro data
- Ladda ner fulltext (pdf) av Combination of polymyxin B and minocycline against multidrug-resistant Klebsiella pneumoniae: interaction quantified by pharmacokinetic/pharmacodynamic modelling from in vitro data
Ingår i Scientific Reports, 2020
- DOI för Population pharmacokinetics of levodopa gel infusion in Parkinson's disease: effects of entacapone infusion and genetic polymorphism
- Ladda ner fulltext (pdf) av Population pharmacokinetics of levodopa gel infusion in Parkinson's disease: effects of entacapone infusion and genetic polymorphism
Ingår i Clinical Microbiology and Infection, s. 1214-1221, 2020
- DOI för Evaluation of polymyxin B in combination with 13 other antibiotics against carbapenemase-producing Klebsiella pneumoniae in time-lapse microscopy and time-kill experiments
- Ladda ner fulltext (pdf) av Evaluation of polymyxin B in combination with 13 other antibiotics against carbapenemase-producing Klebsiella pneumoniae in time-lapse microscopy and time-kill experiments
Ingår i Antimicrobial Agents and Chemotherapy, 2020
- DOI för Efficacy of Antibiotic Combinations against Multidrug-Resistant Pseudomonas aeruginosa in Automated Time-Lapse Microscopy and Static Time-Kill Experiments
- Ladda ner fulltext (pdf) av Efficacy of Antibiotic Combinations against Multidrug-Resistant Pseudomonas aeruginosa in Automated Time-Lapse Microscopy and Static Time-Kill Experiments
Ingår i International Journal of Antimicrobial Agents, 2020
Ingår i Haematologica, s. 1443-1453, 2020
- DOI för Relationship between factor VIII activity, bleeds and individual characteristics in severe hemophilia A patients
- Ladda ner fulltext (pdf) av Relationship between factor VIII activity, bleeds and individual characteristics in severe hemophilia A patients
Ingår i Antimicrobial Agents and Chemotherapy, 2020
- DOI för Extension of Pharmacokinetic/Pharmacodynamic Time-Kill Studies To Include Lipopolysaccharide/Endotoxin Release from Escherichia coli Exposed to Cefuroxime.
- Ladda ner fulltext (pdf) av Extension of Pharmacokinetic/Pharmacodynamic Time-Kill Studies To Include Lipopolysaccharide/Endotoxin Release from Escherichia coli Exposed to Cefuroxime.
Ingår i Journal of Antimicrobial Chemotherapy, s. 400-408, 2020
Ingår i Pediatric Blood & Cancer, 2019
Ingår i PLOS ONE, 2019
- DOI för A non-linear mixed effect model for innate immune response: In vivo kinetics of endotoxin and its induction of the cytokines tumor necrosis factor alpha and interleukin-6
- Ladda ner fulltext (pdf) av A non-linear mixed effect model for innate immune response: In vivo kinetics of endotoxin and its induction of the cytokines tumor necrosis factor alpha and interleukin-6
Ingår i Antimicrobial Agents and Chemotherapy, 2019
Ingår i The International Journal of Chronic Obstructive Pulmonary Disease, s. 2451-2460, 2019
- DOI för A Cross-Sectional Study Assessing Appropriateness Of Inhaled Corticosteroid Treatment In Primary And Secondary Care Patients With COPD In Sweden
- Ladda ner fulltext (pdf) av A Cross-Sectional Study Assessing Appropriateness Of Inhaled Corticosteroid Treatment In Primary And Secondary Care Patients With COPD In Sweden
Bayesian Forecasting Utilizing Bleeding Information to Support Dose Individualization of Factor VIII
Ingår i CPT, s. 894-903, 2019
- DOI för Bayesian Forecasting Utilizing Bleeding Information to Support Dose Individualization of Factor VIII
- Ladda ner fulltext (pdf) av Bayesian Forecasting Utilizing Bleeding Information to Support Dose Individualization of Factor VIII
Ingår i Journal of Antimicrobial Chemotherapy, s. 2984-2993, 2019
- DOI för Population pharmacokinetics of piperacillin in febrile children receiving cancer chemotherapy: the impact of body weight and target on an optimal dosing regimen
- Ladda ner fulltext (pdf) av Population pharmacokinetics of piperacillin in febrile children receiving cancer chemotherapy: the impact of body weight and target on an optimal dosing regimen
Ingår i British Journal of Clinical Pharmacology, s. 1326-1336, 2019
Ingår i British Journal of Clinical Pharmacology, s. 490-500, 2018
Real life experiences of a PK dosing study: Challenges and lessons learned
Ingår i Haemophilia, 2018
Ingår i European Journal of Clinical Pharmacology, s. 1299-1307, 2018
- DOI för Population pharmacokinetics of levodopa/carbidopa microtablets in healthy subjects and Parkinson’s disease patients
- Ladda ner fulltext (pdf) av Population pharmacokinetics of levodopa/carbidopa microtablets in healthy subjects and Parkinson’s disease patients
Predicting mutant selection in competition experiments with ciprofloxacin-exposed Escherichia coli
Ingår i International Journal of Antimicrobial Agents, s. 399-406, 2018
Ingår i Journal of clinical pharmacology, s. 1573-1581, 2017
Ingår i Mycoses, s. 225-225, 2017
Ingår i Journal of Antimicrobial Chemotherapy, s. 3108-3116, 2017
Ingår i Contemporary Clinical Trials, s. 126-132, 2017
Model-based prediction of myelosuppression and recovery based on frequent neutrophil monitoring
Ingår i Cancer Chemotherapy and Pharmacology, s. 343-353, 2017
- DOI för Model-based prediction of myelosuppression and recovery based on frequent neutrophil monitoring
- Ladda ner fulltext (pdf) av Model-based prediction of myelosuppression and recovery based on frequent neutrophil monitoring
Ingår i Clinical Pharmacology and Therapeutics, s. 977-988, 2017
Levodopa-entacapone-carbidopa intestinal gel in Parkinson's disease: A randomized crossover study
Ingår i Movement Disorders, s. 283-286, 2017
Evaluation of automated time-lapse microscopy for assessment of in vitro activity of antibiotics
Ingår i Journal of Microbiological Methods, s. 69-75, 2017
Ingår i Journal of Pharmacokinetics and Pharmacodynamics, s. 69-79, 2017
- DOI för A whole-body physiologically based pharmacokinetic (WB-PBPK) model of ciprofloxacin: a step towards predicting bacterial killing at sites of infection.
- Ladda ner fulltext (pdf) av A whole-body physiologically based pharmacokinetic (WB-PBPK) model of ciprofloxacin: a step towards predicting bacterial killing at sites of infection.
Ingår i Antimicrobial Agents and Chemotherapy, 2017
A non-fatal intoxication and seven deaths involving the dissociative drug 3-MeO-PCP
Ingår i Forensic Science International, s. 76-82, 2017
Ingår i Journal of Antimicrobial Chemotherapy, s. 1279-1290, 2016
Ingår i Journal of Antimicrobial Chemotherapy, s. 1881-1884, 2016
Population Pharmacokinetics of Plasma-Derived Factor IX: Procedures for Dose Individualization
Ingår i Journal of Thrombosis and Haemostasis, s. 724-732, 2016
Ingår i Journal of Antimicrobial Chemotherapy, s. 2521-2533, 2016
Ingår i Pharmaceutical research, s. 1115-1125, 2016
Ingår i Antimicrobial Agents and Chemotherapy, s. 4869-4877, 2016
Ingår i Journal of Antimicrobial Chemotherapy, s. 3051-3060, 2015
Ingår i Pharmaceutical research, s. 754-767, 2014
Population pharmacokinetics of plasma-derived factor IX
Ingår i Haemophilia, s. 80-80, 2014
Population pharmacokinetics of daptomycin in patients affected by severe Gram-positive infections
Ingår i International Journal of Antimicrobial Agents, s. 250-255, 2013
Ingår i Journal of Pharmacokinetics and Pharmacodynamics, 2013
Ingår i Antimicrobial Agents and Chemotherapy, s. 179-188, 2012
Ingår i Antimicrobial Agents and Chemotherapy, s. 4619-4630, 2011
Ingår i Antimicrobial Agents and Chemotherapy, s. 1571-1579, 2011
Ingår i Clinical Pharmacokinetics, s. 253-263, 2009
Ingår i Antimicrobial Agents and Chemotherapy, s. 128-136, 2007
Ingår i Journal of Chromatography B, s. 155-162, 2000
Artiklar, forskningsöversikt
From Therapeutic Drug Monitoring to Model-Informed Precision Dosing for Antibiotic
Ingår i Clinical Pharmacology and Therapeutics, s. 928-941, 2021
Semi-mechanistic pharmacokinetic-pharmacodynamic modelling of antibiotic drug combinations
Ingår i Clinical Microbiology and Infection, s. 697-706, 2018
Ingår i Intensive Care Medicine, s. 1021-1032, 2017
Pharmacokinetic-Pharmacodynamic Modeling of Antibacterial Drugs
Ingår i Pharmacological Reviews, s. 1053-1090, 2013