Elisabet Nielsen

The pharmacokinetics of antibiotics in patients with obesity: a systematic review and consensus guidelines for dose adjustments

Martson, Anne-Grete; Barber, Katie E.; Crass, Ryan L.; Hites, Maya et al.

Ingår i The Lancet - Infectious diseases, 2025

• DOI för The pharmacokinetics of antibiotics in patients with obesity: a systematic review and consensus guidelines for dose adjustments

Model-informed precision dosing of vancomycin in clinical practice: an intervention development study

Swartling, Maria; Hamberg, Anna-Karin; Furebring, Mia; Tängdén, Thomas et al.

Ingår i International Journal of Clinical Pharmacy, s. 178-186, 2025

• DOI för Model-informed precision dosing of vancomycin in clinical practice: an intervention development study
• Ladda ner fulltext (pdf) av Model-informed precision dosing of vancomycin in clinical practice: an intervention development study

Plasma effects on bacterial time-kill dynamics: Insights from a PK/PD modelling analysis

Bahnasawy, Salma M.; Ahmed, Hifza; Zeitlinger, Markus; Friberg, Lena E. et al.

Ingår i International Journal of Antimicrobial Agents, 2025

• DOI för Plasma effects on bacterial time-kill dynamics: Insights from a PK/PD modelling analysis
• Ladda ner fulltext (pdf) av Plasma effects on bacterial time-kill dynamics: Insights from a PK/PD modelling analysis

Physiologically-based pharmacokinetic modelling in sepsis: A tool to elucidate how pathophysiology affects meropenem pharmacokinetics

Bahnasawy, Salma M.; Parrott, Neil J.; Gijsen, Matthias; Spriet, Isabel et al.

Ingår i International Journal of Antimicrobial Agents, 2024

• DOI för Physiologically-based pharmacokinetic modelling in sepsis: A tool to elucidate how pathophysiology affects meropenem pharmacokinetics
• Ladda ner fulltext (pdf) av Physiologically-based pharmacokinetic modelling in sepsis: A tool to elucidate how pathophysiology affects meropenem pharmacokinetics

Therapeutic drug monitoring of monoclonal antibodies in chronic inflammatory diseases: A snapshot of laboratories and applications across Europe

Skrede, Silje; Bogavac-Stanojevic, Natasa; Dreesen, Erwin; Nielsen, Elisabet et al.

Ingår i Basic & Clinical Pharmacology & Toxicology, s. 556-560, 2024

• DOI för Therapeutic drug monitoring of monoclonal antibodies in chronic inflammatory diseases: A snapshot of laboratories and applications across Europe
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Predicting cytokine kinetics during sepsis; a modelling framework from a porcine sepsis model with live Escherichia coli

Bahnasawy, Salma M.; Skorup, Paul; Hanslin, Katja; Friberg, Lena et al.

Ingår i Cytokine, 2023

• DOI för Predicting cytokine kinetics during sepsis; a modelling framework from a porcine sepsis model with live Escherichia coli
• Ladda ner fulltext (pdf) av Predicting cytokine kinetics during sepsis; a modelling framework from a porcine sepsis model with live Escherichia coli

Research priorities towards precision antibiotic therapy to improve patient care

Bulman, Zackery P.; Wicha, Sebastian G.; Nielsen, Elisabet I.; Lenhard, Justin R. et al.

Ingår i The Lancet Microbe, 2022

• DOI för Research priorities towards precision antibiotic therapy to improve patient care
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A novel mechanism-based pharmacokinetic-pharmacodynamic (PKPD) model describing ceftazidime/avibactam efficacy against β-lactamase-producing Gram-negative bacteria

Kristoffersson, Anders N.; Bissantz, Caterina; Okujava, Rusudan; Haldimann, Andreas et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 400-408, 2020

• DOI för A novel mechanism-based pharmacokinetic-pharmacodynamic (PKPD) model describing ceftazidime/avibactam efficacy against β-lactamase-producing Gram-negative bacteria

Handling interoccasion variability in model-based dose individualization using therapeutic drug monitoring data

Abrantes, João A.; Jönsson, Siv; Karlsson, Mats; Nielsen, Elisabet I.

Ingår i British Journal of Clinical Pharmacology, s. 1326-1336, 2019

• DOI för Handling interoccasion variability in model-based dose individualization using therapeutic drug monitoring data

Pharmacokinetic-Pharmacodynamic Modeling of Antibacterial Drugs

Nielsen, Elisabet I.; Friberg, Lena E.

Ingår i Pharmacological Reviews, s. 1053-1090, 2013

• DOI för Pharmacokinetic-Pharmacodynamic Modeling of Antibacterial Drugs

Unbound cloxacillin plasma concentrations in relation to toxicity and renal function: protocol for a prospective, observational clinical trial in a real-world Staphylococcus aureus bacteraemia population.

Damgaard, Tobias; Hellborg, Thomas; Larsson, Anders; Eliasson, Erik et al.

Ingår i BMJ Open, 2026

• DOI för Unbound cloxacillin plasma concentrations in relation to toxicity and renal function: protocol for a prospective, observational clinical trial in a real-world Staphylococcus aureus bacteraemia population.
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Population pharmacokinetic modelling of cetirizine concentrations in human breast milk: A contribution from the ConcePTION project

Melander, Erik; Nielsen, Elisabet I.; Lindqvist, Annika; Hovd, Markus et al.

Ingår i Basic & Clinical Pharmacology & Toxicology, 2025

• DOI för Population pharmacokinetic modelling of cetirizine concentrations in human breast milk: A contribution from the ConcePTION project
• Ladda ner fulltext (pdf) av Population pharmacokinetic modelling of cetirizine concentrations in human breast milk: A contribution from the ConcePTION project

Therapeutic drug monitoring (TDM) of β-lactam/β-lactamase inhibitor (BL/BLI) drug combinations: insights from a pharmacometric simulation study

O'Jeanson, Amaury; Nielsen, Elisabet I.; Friberg, Lena E.

Ingår i Journal of Antimicrobial Chemotherapy, s. 79-86, 2025

• DOI för Therapeutic drug monitoring (TDM) of β-lactam/β-lactamase inhibitor (BL/BLI) drug combinations: insights from a pharmacometric simulation study
• Ladda ner fulltext (pdf) av Therapeutic drug monitoring (TDM) of β-lactam/β-lactamase inhibitor (BL/BLI) drug combinations: insights from a pharmacometric simulation study

Predictors of Ability to Work in Multiple Sclerosis

Wellhagen, Gustaf; Ueckert, Sebastian; Nielsen, Elisabet I.; Smith, Carl et al.

Ingår i CPT, s. 2244-2251, 2025

• DOI för Predictors of Ability to Work in Multiple Sclerosis
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Comparison of pre-mortem and post-mortem blood concentrations of analgesic and sedative drugs in intensive care patients

Lennborn, Ulrica; Johansson, Anna; Lindgren, Erik; Nielsen, Elisabet I. et al.

Ingår i Forensic Science International, 2025

• DOI för Comparison of pre-mortem and post-mortem blood concentrations of analgesic and sedative drugs in intensive care patients
• Ladda ner fulltext (pdf) av Comparison of pre-mortem and post-mortem blood concentrations of analgesic and sedative drugs in intensive care patients

Unbound cloxacillin plasma concentrations in relation to toxicity and renal function: protocol for a prospective, observational clinical trial in a real-world Staphylococcus aureus bacteraemia population.

Damgaard, Tobias; Hellborg, Thomas; Larsson, Anders; Eliasson, Erik et al.

Ingår i BMJ Open, 2026

• DOI för Unbound cloxacillin plasma concentrations in relation to toxicity and renal function: protocol for a prospective, observational clinical trial in a real-world Staphylococcus aureus bacteraemia population.
• Ladda ner fulltext (pdf) av Unbound cloxacillin plasma concentrations in relation to toxicity and renal function: protocol for a prospective, observational clinical trial in a real-world Staphylococcus aureus bacteraemia population.

Population pharmacokinetic modelling of cetirizine concentrations in human breast milk: A contribution from the ConcePTION project

Melander, Erik; Nielsen, Elisabet I.; Lindqvist, Annika; Hovd, Markus et al.

Ingår i Basic & Clinical Pharmacology & Toxicology, 2025

• DOI för Population pharmacokinetic modelling of cetirizine concentrations in human breast milk: A contribution from the ConcePTION project
• Ladda ner fulltext (pdf) av Population pharmacokinetic modelling of cetirizine concentrations in human breast milk: A contribution from the ConcePTION project

Therapeutic drug monitoring (TDM) of β-lactam/β-lactamase inhibitor (BL/BLI) drug combinations: insights from a pharmacometric simulation study

O'Jeanson, Amaury; Nielsen, Elisabet I.; Friberg, Lena E.

Ingår i Journal of Antimicrobial Chemotherapy, s. 79-86, 2025

• DOI för Therapeutic drug monitoring (TDM) of β-lactam/β-lactamase inhibitor (BL/BLI) drug combinations: insights from a pharmacometric simulation study
• Ladda ner fulltext (pdf) av Therapeutic drug monitoring (TDM) of β-lactam/β-lactamase inhibitor (BL/BLI) drug combinations: insights from a pharmacometric simulation study

Predictors of Ability to Work in Multiple Sclerosis

Wellhagen, Gustaf; Ueckert, Sebastian; Nielsen, Elisabet I.; Smith, Carl et al.

Ingår i CPT, s. 2244-2251, 2025

• DOI för Predictors of Ability to Work in Multiple Sclerosis
• Ladda ner fulltext (pdf) av Predictors of Ability to Work in Multiple Sclerosis

Comparison of pre-mortem and post-mortem blood concentrations of analgesic and sedative drugs in intensive care patients

Lennborn, Ulrica; Johansson, Anna; Lindgren, Erik; Nielsen, Elisabet I. et al.

Ingår i Forensic Science International, 2025

• DOI för Comparison of pre-mortem and post-mortem blood concentrations of analgesic and sedative drugs in intensive care patients
• Ladda ner fulltext (pdf) av Comparison of pre-mortem and post-mortem blood concentrations of analgesic and sedative drugs in intensive care patients

Improved Medication communication and Patient involvement At Care Transitions (IMPACT-care): study protocol for a pre–post intervention trial in older hospitalised patients

Cam, Henrik; Franzon, Kristin; Östman, Victoria; Kälvemark Sporrong, Sofia et al.

Ingår i BMJ Open, 2025

• DOI för Improved Medication communication and Patient involvement At Care Transitions (IMPACT-care): study protocol for a pre–post intervention trial in older hospitalised patients
• Ladda ner fulltext (pdf) av Improved Medication communication and Patient involvement At Care Transitions (IMPACT-care): study protocol for a pre–post intervention trial in older hospitalised patients

Short, extended and continuous infusion of β-lactams: predicted impact on target attainment and risk for toxicity in an ICU patient cohort

Smekal, Anna-Karin; Swartling, Maria; Furebring, Mia; Giske, Christian G et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 876-884, 2025

• DOI för Short, extended and continuous infusion of β-lactams: predicted impact on target attainment and risk for toxicity in an ICU patient cohort
• Ladda ner fulltext (pdf) av Short, extended and continuous infusion of β-lactams: predicted impact on target attainment and risk for toxicity in an ICU patient cohort

Utilizing gentamicin concentrations to estimate glomerular filtration rate in intensive care unit patients

Smekal, Anna-Karin; Swartling, Maria; Nielsen, Elisabet I.; Furebring, Mia et al.

Ingår i Scientific Reports, 2025

• DOI för Utilizing gentamicin concentrations to estimate glomerular filtration rate in intensive care unit patients
• Ladda ner fulltext (pdf) av Utilizing gentamicin concentrations to estimate glomerular filtration rate in intensive care unit patients

First dose target attainment with extended infusion regimens of piperacillin and meropenem

Beijer, Gustaf; Swartling, Maria; Nielsen, Elisabet I.; Breuer, Olof et al.

Ingår i Critical Care, 2025

• DOI för First dose target attainment with extended infusion regimens of piperacillin and meropenem
• Ladda ner fulltext (pdf) av First dose target attainment with extended infusion regimens of piperacillin and meropenem

A model-based evaluation of the pharmacokinetics-pharmacodynamics (PKPD) of avibactam in combination with ceftazidime

O'Jeanson, Amaury; Nielsen, Elisabet I.; Friberg, Lena E.

Ingår i JAC - Antimicrobial Resistance, 2025

• DOI för A model-based evaluation of the pharmacokinetics-pharmacodynamics (PKPD) of avibactam in combination with ceftazidime
• Ladda ner fulltext (pdf) av A model-based evaluation of the pharmacokinetics-pharmacodynamics (PKPD) of avibactam in combination with ceftazidime

An integrative and translational PKPD modelling approach to explore the combined effect of polymyxin B and minocycline against Klebsiella pneumoniae

Zhao, Chenyan; van den Berg, Sanne; Wang, Zhigang; Olsson, Anna et al.

Ingår i International Journal of Antimicrobial Agents, 2025

• DOI för An integrative and translational PKPD modelling approach to explore the combined effect of polymyxin B and minocycline against Klebsiella pneumoniae
• Ladda ner fulltext (pdf) av An integrative and translational PKPD modelling approach to explore the combined effect of polymyxin B and minocycline against Klebsiella pneumoniae

Model-informed precision dosing of vancomycin in clinical practice: an intervention development study

Swartling, Maria; Hamberg, Anna-Karin; Furebring, Mia; Tängdén, Thomas et al.

Ingår i International Journal of Clinical Pharmacy, s. 178-186, 2025

• DOI för Model-informed precision dosing of vancomycin in clinical practice: an intervention development study
• Ladda ner fulltext (pdf) av Model-informed precision dosing of vancomycin in clinical practice: an intervention development study

Plasma effects on bacterial time-kill dynamics: Insights from a PK/PD modelling analysis

Bahnasawy, Salma M.; Ahmed, Hifza; Zeitlinger, Markus; Friberg, Lena E. et al.

Ingår i International Journal of Antimicrobial Agents, 2025

• DOI för Plasma effects on bacterial time-kill dynamics: Insights from a PK/PD modelling analysis
• Ladda ner fulltext (pdf) av Plasma effects on bacterial time-kill dynamics: Insights from a PK/PD modelling analysis

Ceftazidime-avibactam (CAZ-AVI) pharmacokinetics in critically ill patients undergoing continuous venovenous hemodiafiltration (CVVHDF)

O'Jeanson, Amaury; Ioannidis, Konstantinos; Nielsen, Elisabet I.; Galani, Lamprini et al.

Ingår i International Journal of Antimicrobial Agents, 2025

• DOI för Ceftazidime-avibactam (CAZ-AVI) pharmacokinetics in critically ill patients undergoing continuous venovenous hemodiafiltration (CVVHDF)
• Ladda ner fulltext (pdf) av Ceftazidime-avibactam (CAZ-AVI) pharmacokinetics in critically ill patients undergoing continuous venovenous hemodiafiltration (CVVHDF)

Model-based translation of results from in vitro to in vivo experiments for afabicin activity against Staphylococcus aureus

Saporta, Raphaël; Nielsen, Elisabet I.; Menetrey, Annick; Cameron, David R et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 3150-3159, 2024

• DOI för Model-based translation of results from in vitro to in vivo experiments for afabicin activity against Staphylococcus aureus
• Ladda ner fulltext (pdf) av Model-based translation of results from in vitro to in vivo experiments for afabicin activity against Staphylococcus aureus

Nya rekommendationer för infusion av betalaktamantibiotika

Gustafsson, Tove; Eliasson, Erik; Furebring, Mia; Nielsen, Elisabet I. et al.

Ingår i Läkartidningen, 2024

Recommended dosages of analgesic and sedative drugs in intensive care result in a low incidence of potentially toxic blood concentrations

Lennborn, Ulrica; Johansson, Anna; Lindgren, Erik; Nielsen, Elisabet I. et al.

Ingår i Upsala Journal of Medical Sciences, 2024

• DOI för Recommended dosages of analgesic and sedative drugs in intensive care result in a low incidence of potentially toxic blood concentrations
• Ladda ner fulltext (pdf) av Recommended dosages of analgesic and sedative drugs in intensive care result in a low incidence of potentially toxic blood concentrations

'You're Just Thinking About Going Home': Exploring Person-Centred Medication Communication With Older Patients at Hospital Discharge

Cam, Henrik; Franzon, Kristin; Kälvemark Sporrong, Sofia; Kempen, Thomas Gerardus Hendrik et al.

Ingår i Health Expectations, 2024

• DOI för 'You're Just Thinking About Going Home': Exploring Person-Centred Medication Communication With Older Patients at Hospital Discharge
• Ladda ner fulltext (pdf) av 'You're Just Thinking About Going Home': Exploring Person-Centred Medication Communication With Older Patients at Hospital Discharge

Physiologically-based pharmacokinetic modelling in sepsis: A tool to elucidate how pathophysiology affects meropenem pharmacokinetics

Bahnasawy, Salma M.; Parrott, Neil J.; Gijsen, Matthias; Spriet, Isabel et al.

Ingår i International Journal of Antimicrobial Agents, 2024

• DOI för Physiologically-based pharmacokinetic modelling in sepsis: A tool to elucidate how pathophysiology affects meropenem pharmacokinetics
• Ladda ner fulltext (pdf) av Physiologically-based pharmacokinetic modelling in sepsis: A tool to elucidate how pathophysiology affects meropenem pharmacokinetics

PK/PD modelling and simulation of longitudinal meropenem in vivo effects against Escherichia coli and Klebsiella pneumoniae strains with high MICs

Saporta, Raphaël; Nielsen, Elisabet I.; Hansen, Jon U.; Liepinsh, Edgars et al.

Ingår i International Journal of Antimicrobial Agents, 2024

• DOI för PK/PD modelling and simulation of longitudinal meropenem in vivo effects against Escherichia coli and Klebsiella pneumoniae strains with high MICs
• Ladda ner fulltext (pdf) av PK/PD modelling and simulation of longitudinal meropenem in vivo effects against Escherichia coli and Klebsiella pneumoniae strains with high MICs

Therapeutic drug monitoring of monoclonal antibodies in chronic inflammatory diseases: A snapshot of laboratories and applications across Europe

Skrede, Silje; Bogavac-Stanojevic, Natasa; Dreesen, Erwin; Nielsen, Elisabet et al.

Ingår i Basic & Clinical Pharmacology & Toxicology, s. 556-560, 2024

• DOI för Therapeutic drug monitoring of monoclonal antibodies in chronic inflammatory diseases: A snapshot of laboratories and applications across Europe
• Ladda ner fulltext (pdf) av Therapeutic drug monitoring of monoclonal antibodies in chronic inflammatory diseases: A snapshot of laboratories and applications across Europe

Quantifying combined effects of colistin and ciprofloxacin against Escherichia coli in an in silico pharmacokinetic-pharmacodynamic model

Zhao, Chenyan; Kristoffersson, Anders N.; Khan, David D.; Lagerbäck, Pernilla et al.

Ingår i Scientific Reports, 2024

• DOI för Quantifying combined effects of colistin and ciprofloxacin against Escherichia coli in an in silico pharmacokinetic-pharmacodynamic model
• Ladda ner fulltext (pdf) av Quantifying combined effects of colistin and ciprofloxacin against Escherichia coli in an in silico pharmacokinetic-pharmacodynamic model

Estimated glomerular filtration rate as a tool for early identification of patients with insufficient exposure to beta-lactam antibiotics in intensive care units

Damgaard, Tobias; Woksepp, Hanna; Brudin, Lars; Bonnedahl, Jonas et al.

Ingår i Infectious Diseases, s. 451-459, 2024

• DOI för Estimated glomerular filtration rate as a tool for early identification of patients with insufficient exposure to beta-lactam antibiotics in intensive care units
• Ladda ner fulltext (pdf) av Estimated glomerular filtration rate as a tool for early identification of patients with insufficient exposure to beta-lactam antibiotics in intensive care units

Failure to Involve Older Hospitalised Patients in Medication Decisions: A Change of Approach is Called For

Cam, Henrik; Gillespie, Ulrika; Kälvemark Sporrong, Sofia; Nielsen, Elisabet I. et al.

Ingår i Research in Social and Administrative Pharmacy, s. 216-217, 2024

• DOI för Failure to Involve Older Hospitalised Patients in Medication Decisions: A Change of Approach is Called For

Therapeutic drug monitoring of vancomycin and meropenem: Illustration of the impact of inaccurate information in dose administration time

Swartling, Maria; Tängdén, Thomas; Lipcsey, Miklós; Jönsson, Siv et al.

Ingår i International Journal of Antimicrobial Agents, 2023

• DOI för Therapeutic drug monitoring of vancomycin and meropenem: Illustration of the impact of inaccurate information in dose administration time
• Ladda ner fulltext (pdf) av Therapeutic drug monitoring of vancomycin and meropenem: Illustration of the impact of inaccurate information in dose administration time

The complexities of communication at hospital discharge of older patients: a qualitative study of healthcare professionals' views

Cam, Henrik; Wennlöf, Björn; Gillespie, Ulrika; Franzon, Kristin et al.

Ingår i BMC Health Services Research, 2023

• DOI för The complexities of communication at hospital discharge of older patients: a qualitative study of healthcare professionals' views
• Ladda ner fulltext (pdf) av The complexities of communication at hospital discharge of older patients: a qualitative study of healthcare professionals' views

Predicting cytokine kinetics during sepsis; a modelling framework from a porcine sepsis model with live Escherichia coli

Bahnasawy, Salma M.; Skorup, Paul; Hanslin, Katja; Friberg, Lena et al.

Ingår i Cytokine, 2023

• DOI för Predicting cytokine kinetics during sepsis; a modelling framework from a porcine sepsis model with live Escherichia coli
• Ladda ner fulltext (pdf) av Predicting cytokine kinetics during sepsis; a modelling framework from a porcine sepsis model with live Escherichia coli

Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time-kill experiments: high agreement with in silico predictions

Olsson, Anna; Malmberg, Christer; Zhao, Chenyan; Friberg, Lena et al.

Ingår i Journal of Antimicrobial Chemotherapy, 2023

• DOI för Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time-kill experiments: high agreement with in silico predictions
• Ladda ner fulltext (pdf) av Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time-kill experiments: high agreement with in silico predictions

Model‐based assessment of neutrophil‐mediated phagocytosis and digestion of bacteria across in vitro and in vivo studies

Thorsted, Anders; Pham, Anh Duc; Friberg, Lena E.; Nielsen, Elisabet I.

Ingår i CPT, s. 1972-1987, 2023

• DOI för Model‐based assessment of neutrophil‐mediated phagocytosis and digestion of bacteria across in vitro and in vivo studies
• Ladda ner fulltext (pdf) av Model‐based assessment of neutrophil‐mediated phagocytosis and digestion of bacteria across in vitro and in vivo studies

Risk factors for and preventability of drug‐related hospital revisits in older patients: A post‐hoc analysis of a randomized clinical trial

Kempen, Thomas; Hedman, Anton N.; Hadziosmanovic, Nermin; Lindner, Karl‐Johan et al.

Ingår i British Journal of Clinical Pharmacology, s. 1575-1587, 2023

• DOI för Risk factors for and preventability of drug‐related hospital revisits in older patients: A post‐hoc analysis of a randomized clinical trial
• Ladda ner fulltext (pdf) av Risk factors for and preventability of drug‐related hospital revisits in older patients: A post‐hoc analysis of a randomized clinical trial

Research priorities towards precision antibiotic therapy to improve patient care

Bulman, Zackery P.; Wicha, Sebastian G.; Nielsen, Elisabet I.; Lenhard, Justin R. et al.

Ingår i The Lancet Microbe, 2022

• DOI för Research priorities towards precision antibiotic therapy to improve patient care
• Ladda ner fulltext (pdf) av Research priorities towards precision antibiotic therapy to improve patient care

Population pharmacokinetics of cefotaxime in intensive care patients

Swartling, Maria; Smekal, Anna-Karin; Furebring, Mia; Lipcsey, Miklós et al.

Ingår i European Journal of Clinical Pharmacology, s. 251-258, 2022

• DOI för Population pharmacokinetics of cefotaxime in intensive care patients
• Ladda ner fulltext (pdf) av Population pharmacokinetics of cefotaxime in intensive care patients

Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors

Brem, Jürgen; Panduwawala, Tharindi; Hansen, Jon Ulf; Hewitt, Joanne et al.

Ingår i Nature Chemistry, s. 15-24, 2022

• DOI för Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors

Changes in critical inhaler technique errors in inhaled COPD treatment: A one-year follow-up study in Sweden

Sulku, Johanna; Janson, Christer; Melhus, Håkan; Ställberg, Björn et al.

Ingår i Respiratory Medicine, 2022

• DOI för Changes in critical inhaler technique errors in inhaled COPD treatment: A one-year follow-up study in Sweden
• Ladda ner fulltext (pdf) av Changes in critical inhaler technique errors in inhaled COPD treatment: A one-year follow-up study in Sweden

Quantitation of seven sedative and analgesic drugs in whole blood from intensive care patients using liquid chromatography mass spectrometry

Johansson, Anna; Ahlner, Johan; Lennborn, Ulrica; Nielsen, Elisabet I. et al.

Ingår i TOXICOLOGIE ANALYTIQUE ET CLINIQUE, s. 327-337, 2021

• DOI för Quantitation of seven sedative and analgesic drugs in whole blood from intensive care patients using liquid chromatography mass spectrometry

Effects of Hospital-Based Comprehensive Medication Reviews Including Postdischarge Follow-up on Older Patients' Use of Health Care: A Cluster Randomized Clinical Trial

Kempen, Thomas; Bertilsson, Maria; Hadziosmanovic, Nermin; Lindner, Karl-Johan et al.

Ingår i JAMA Network Open, 2021

• DOI för Effects of Hospital-Based Comprehensive Medication Reviews Including Postdischarge Follow-up on Older Patients' Use of Health Care: A Cluster Randomized Clinical Trial
• Ladda ner fulltext (pdf) av Effects of Hospital-Based Comprehensive Medication Reviews Including Postdischarge Follow-up on Older Patients' Use of Health Care: A Cluster Randomized Clinical Trial

Critical inhaler technique errors in Swedish patients with COPD: a cross-sectional study analysing video-recorded demonstrations

Sulku, Johanna; Bröms, Kristina; Högman, Marieann; Janson, Christer et al.

Ingår i npj Primary Care Respiratory Medicine, 2021

• DOI för Critical inhaler technique errors in Swedish patients with COPD: a cross-sectional study analysing video-recorded demonstrations
• Ladda ner fulltext (pdf) av Critical inhaler technique errors in Swedish patients with COPD: a cross-sectional study analysing video-recorded demonstrations

Continuous infusion of piperacillin‐tazobactam significantly improves target attainment in children with cancer and fever

Maarbjerg, Sabine F.; Thorsted, Anders; Friberg, Lena; Nielsen, Elisabet I. et al.

Ingår i Cancer Reports, 2021

• DOI för Continuous infusion of piperacillin‐tazobactam significantly improves target attainment in children with cancer and fever
• Ladda ner fulltext (pdf) av Continuous infusion of piperacillin‐tazobactam significantly improves target attainment in children with cancer and fever

Intervention fidelity and process outcomes of medication reviews including post-discharge follow-up in older hospitalized patients: Process evaluation of the MedBridge trial.

Kempen, Thomas; Cam, Henrik; Kälvemark, Amanda; Lindner, Karl-Johan et al.

Ingår i Journal of Clinical Pharmacy and Therapeutics, s. 1021-1029, 2020

• DOI för Intervention fidelity and process outcomes of medication reviews including post-discharge follow-up in older hospitalized patients: Process evaluation of the MedBridge trial.
• Ladda ner fulltext (pdf) av Intervention fidelity and process outcomes of medication reviews including post-discharge follow-up in older hospitalized patients: Process evaluation of the MedBridge trial.

Combination of polymyxin B and minocycline against multidrug-resistant Klebsiella pneumoniae: interaction quantified by pharmacokinetic/pharmacodynamic modelling from in vitro data

Zhao, Chenyan; Wistrand-Yuen, Pikkei; Lagerbäck, Pernilla; Tängdén, Thomas et al.

Ingår i International Journal of Antimicrobial Agents, 2020

• DOI för Combination of polymyxin B and minocycline against multidrug-resistant Klebsiella pneumoniae: interaction quantified by pharmacokinetic/pharmacodynamic modelling from in vitro data
• Ladda ner fulltext (pdf) av Combination of polymyxin B and minocycline against multidrug-resistant Klebsiella pneumoniae: interaction quantified by pharmacokinetic/pharmacodynamic modelling from in vitro data

Population pharmacokinetics of levodopa gel infusion in Parkinson's disease: effects of entacapone infusion and genetic polymorphism

Senek, Marina; Nyholm, Dag; Nielsen, Elisabet I.

Ingår i Scientific Reports, 2020

• DOI för Population pharmacokinetics of levodopa gel infusion in Parkinson's disease: effects of entacapone infusion and genetic polymorphism
• Ladda ner fulltext (pdf) av Population pharmacokinetics of levodopa gel infusion in Parkinson's disease: effects of entacapone infusion and genetic polymorphism

Evaluation of polymyxin B in combination with 13 other antibiotics against carbapenemase-producing Klebsiella pneumoniae in time-lapse microscopy and time-kill experiments

Wistrand-Yuen, Pikkei; Olsson, Anna; Skarp, Kari Pekka; Friberg, Lena et al.

Ingår i Clinical Microbiology and Infection, s. 1214-1221, 2020

• DOI för Evaluation of polymyxin B in combination with 13 other antibiotics against carbapenemase-producing Klebsiella pneumoniae in time-lapse microscopy and time-kill experiments
• Ladda ner fulltext (pdf) av Evaluation of polymyxin B in combination with 13 other antibiotics against carbapenemase-producing Klebsiella pneumoniae in time-lapse microscopy and time-kill experiments

Efficacy of Antibiotic Combinations against Multidrug-Resistant Pseudomonas aeruginosa in Automated Time-Lapse Microscopy and Static Time-Kill Experiments

Olsson, Anna; Wistrand-Yuen, Pikkei; Nielsen, Elisabet I.; Friberg, Lena et al.

Ingår i Antimicrobial Agents and Chemotherapy, 2020

• DOI för Efficacy of Antibiotic Combinations against Multidrug-Resistant Pseudomonas aeruginosa in Automated Time-Lapse Microscopy and Static Time-Kill Experiments
• Ladda ner fulltext (pdf) av Efficacy of Antibiotic Combinations against Multidrug-Resistant Pseudomonas aeruginosa in Automated Time-Lapse Microscopy and Static Time-Kill Experiments

Pharmacodynamics of immune response biomarkers of interest for evaluation of treatment effects in bacterial infections

Thorsted, Anders; Nielsen, Elisabet I.; Friberg, Lena

Ingår i International Journal of Antimicrobial Agents, 2020

• DOI för Pharmacodynamics of immune response biomarkers of interest for evaluation of treatment effects in bacterial infections

Relationship between factor VIII activity, bleeds and individual characteristics in severe hemophilia A patients

Abrantes, João A.; Solms, Alexander; Garmann, Dirk; Nielsen, Elisabet I. et al.

Ingår i Haematologica, s. 1443-1453, 2020

• DOI för Relationship between factor VIII activity, bleeds and individual characteristics in severe hemophilia A patients
• Ladda ner fulltext (pdf) av Relationship between factor VIII activity, bleeds and individual characteristics in severe hemophilia A patients

Extension of Pharmacokinetic/Pharmacodynamic Time-Kill Studies To Include Lipopolysaccharide/Endotoxin Release from Escherichia coli Exposed to Cefuroxime.

Thorsted, Anders; Tano, Eva; Kaivonen, Kia; Sjölin, Jan et al.

Ingår i Antimicrobial Agents and Chemotherapy, 2020

• DOI för Extension of Pharmacokinetic/Pharmacodynamic Time-Kill Studies To Include Lipopolysaccharide/Endotoxin Release from Escherichia coli Exposed to Cefuroxime.
• Ladda ner fulltext (pdf) av Extension of Pharmacokinetic/Pharmacodynamic Time-Kill Studies To Include Lipopolysaccharide/Endotoxin Release from Escherichia coli Exposed to Cefuroxime.

A novel mechanism-based pharmacokinetic-pharmacodynamic (PKPD) model describing ceftazidime/avibactam efficacy against β-lactamase-producing Gram-negative bacteria

Kristoffersson, Anders N.; Bissantz, Caterina; Okujava, Rusudan; Haldimann, Andreas et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 400-408, 2020

• DOI för A novel mechanism-based pharmacokinetic-pharmacodynamic (PKPD) model describing ceftazidime/avibactam efficacy against β-lactamase-producing Gram-negative bacteria

Piperacillin pharmacokinetics and target attainment in children with cancer and fever: Can we optimize our dosing strategy?

Maarbjerg, Sabine F.; Thorsted, Anders; Kristoffersson, Anders; Friberg, Lena E. et al.

Ingår i Pediatric Blood & Cancer, 2019

• DOI för Piperacillin pharmacokinetics and target attainment in children with cancer and fever: Can we optimize our dosing strategy?

A non-linear mixed effect model for innate immune response: In vivo kinetics of endotoxin and its induction of the cytokines tumor necrosis factor alpha and interleukin-6

Thorsted, Anders; Bouchene, Salim; Tano, Eva; Castegren, Markus et al.

Ingår i PLOS ONE, 2019

• DOI för A non-linear mixed effect model for innate immune response: In vivo kinetics of endotoxin and its induction of the cytokines tumor necrosis factor alpha and interleukin-6
• Ladda ner fulltext (pdf) av A non-linear mixed effect model for innate immune response: In vivo kinetics of endotoxin and its induction of the cytokines tumor necrosis factor alpha and interleukin-6

Pharmacokinetics of Caspofungin in Critically Ill Patients in Relation to Liver Dysfunction: Differential Impact of Plasma Albumin and Bilirubin Levels

Kurland, Siri; Furebring, Mia; Löwdin, Elisabeth; Eliasson, E. et al.

Ingår i Antimicrobial Agents and Chemotherapy, 2019

• DOI för Pharmacokinetics of Caspofungin in Critically Ill Patients in Relation to Liver Dysfunction: Differential Impact of Plasma Albumin and Bilirubin Levels

A Cross-Sectional Study Assessing Appropriateness Of Inhaled Corticosteroid Treatment In Primary And Secondary Care Patients With COPD In Sweden

Sulku, Johanna; Jansson, Christer; Melhus, Håkan; Malinovschi, Andrei et al.

Ingår i The International Journal of Chronic Obstructive Pulmonary Disease, s. 2451-2460, 2019

• DOI för A Cross-Sectional Study Assessing Appropriateness Of Inhaled Corticosteroid Treatment In Primary And Secondary Care Patients With COPD In Sweden
• Ladda ner fulltext (pdf) av A Cross-Sectional Study Assessing Appropriateness Of Inhaled Corticosteroid Treatment In Primary And Secondary Care Patients With COPD In Sweden

Bayesian Forecasting Utilizing Bleeding Information to Support Dose Individualization of Factor VIII

Abrantes, João A.; Solms, Alexander; Garmann, Dirk; Nielsen, Elisabet I. et al.

Ingår i CPT, s. 894-903, 2019

• DOI för Bayesian Forecasting Utilizing Bleeding Information to Support Dose Individualization of Factor VIII
• Ladda ner fulltext (pdf) av Bayesian Forecasting Utilizing Bleeding Information to Support Dose Individualization of Factor VIII

Population pharmacokinetics of piperacillin in febrile children receiving cancer chemotherapy: the impact of body weight and target on an optimal dosing regimen

Thorsted, Anders; Kristoffersson, Anders N.; Maarbjerg, Sabine F.; Schrøder, Henrik et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 2984-2993, 2019

• DOI för Population pharmacokinetics of piperacillin in febrile children receiving cancer chemotherapy: the impact of body weight and target on an optimal dosing regimen
• Ladda ner fulltext (pdf) av Population pharmacokinetics of piperacillin in febrile children receiving cancer chemotherapy: the impact of body weight and target on an optimal dosing regimen

Handling interoccasion variability in model-based dose individualization using therapeutic drug monitoring data

Abrantes, João A.; Jönsson, Siv; Karlsson, Mats; Nielsen, Elisabet I.

Ingår i British Journal of Clinical Pharmacology, s. 1326-1336, 2019

• DOI för Handling interoccasion variability in model-based dose individualization using therapeutic drug monitoring data

The risk of febrile neutropenia in breast cancer patients following adjuvant chemotherapy is predicted by the time course of interleukin-6 and C-reactive protein by modelling.

Netterberg, Ida; Karlsson, Mats O; Nielsen, Elisabet I.; Quartino, Angelica L et al.

Ingår i British Journal of Clinical Pharmacology, s. 490-500, 2018

• DOI för The risk of febrile neutropenia in breast cancer patients following adjuvant chemotherapy is predicted by the time course of interleukin-6 and C-reactive protein by modelling.

Real life experiences of a PK dosing study: Challenges and lessons learned

Mangles, S.; Rea, C.; Madan, B.; Nielsen, Elisabet I. et al.

Ingår i Haemophilia, 2018

• DOI för Real life experiences of a PK dosing study: Challenges and lessons learned

Population pharmacokinetics of levodopa/carbidopa microtablets in healthy subjects and Parkinson’s disease patients

Senek, Marina; Nyholm, Dag; Nielsen, Elisabet I.

Ingår i European Journal of Clinical Pharmacology, s. 1299-1307, 2018

• DOI för Population pharmacokinetics of levodopa/carbidopa microtablets in healthy subjects and Parkinson’s disease patients
• Ladda ner fulltext (pdf) av Population pharmacokinetics of levodopa/carbidopa microtablets in healthy subjects and Parkinson’s disease patients

Predicting mutant selection in competition experiments with ciprofloxacin-exposed Escherichia coli

Khan, David; Lagerbäck, Pernilla; Malmberg, Christer; Kristoffersson, Anders et al.

Ingår i International Journal of Antimicrobial Agents, s. 399-406, 2018

• DOI för Predicting mutant selection in competition experiments with ciprofloxacin-exposed Escherichia coli

Population Pharmacokinetic Analysis of Vaginally and Intravenously Administered Oxytocin in Postmenopausal Women

Nielsen, Elisabet I.; Al-Saqi, Shahla H.; Jonasson, Aino F.; Uvnäs-Moberg, Kerstin

Ingår i Journal of clinical pharmacology, s. 1573-1581, 2017

• DOI för Population Pharmacokinetic Analysis of Vaginally and Intravenously Administered Oxytocin in Postmenopausal Women

Elimination ability of caspofungin in critically ill patients in relation to liver dysfunction in an ICU setting

Kurland, Siri; Furebring, Mia; Löwdin, Elisabeth; Nielsen, Elisabet I. et al.

Ingår i Mycoses, s. 225-225, 2017

Can a pharmacokinetic/pharmacodynamic (PKPD) model be predictive across bacterial densities and strains?: External evaluation of a PKPD model describing longitudinal in vitro data

Nielsen, Elisabet I.; Khan, David D.; Cao, Sha; Lustig, Ulrika et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 3108-3116, 2017

• DOI för Can a pharmacokinetic/pharmacodynamic (PKPD) model be predictive across bacterial densities and strains?: External evaluation of a PKPD model describing longitudinal in vitro data

Medication Reviews Bridging Healthcare (MedBridge): Study protocol for a pragmatic cluster-randomised crossover trial

Kempen, Thomas; Bertilsson, Maria; Lindner, Karl-Johan; Sulku, Johanna et al.

Ingår i Contemporary Clinical Trials, s. 126-132, 2017

• DOI för Medication Reviews Bridging Healthcare (MedBridge): Study protocol for a pragmatic cluster-randomised crossover trial

Model-based prediction of myelosuppression and recovery based on frequent neutrophil monitoring

Netterberg, Ida; Nielsen, Elisabet I.; Friberg, Lena E; Karlsson, Mats O.

Ingår i Cancer Chemotherapy and Pharmacology, s. 343-353, 2017

• DOI för Model-based prediction of myelosuppression and recovery based on frequent neutrophil monitoring
• Ladda ner fulltext (pdf) av Model-based prediction of myelosuppression and recovery based on frequent neutrophil monitoring

Elucidation of Factor VIII Activity Pharmacokinetics: A Pooled Population Analysis in Patients With Hemophilia A Treated With Moroctocog Alfa

Abrantes, João A.; Nielsen, Elisabet I.; Korth-Bradley, J.; Harnisch, L. et al.

Ingår i Clinical Pharmacology and Therapeutics, s. 977-988, 2017

• DOI för Elucidation of Factor VIII Activity Pharmacokinetics: A Pooled Population Analysis in Patients With Hemophilia A Treated With Moroctocog Alfa

Levodopa-entacapone-carbidopa intestinal gel in Parkinson's disease: A randomized crossover study

Senek, Marina; Nielsen, Elisabet I.; Nyholm, Dag

Ingår i Movement Disorders, s. 283-286, 2017

• DOI för Levodopa-entacapone-carbidopa intestinal gel in Parkinson's disease: A randomized crossover study

Evaluation of automated time-lapse microscopy for assessment of in vitro activity of antibiotics

Ungphakorn, Wanchana; Malmberg, Christer; Lagerbäck, Pernilla; Cars, Otto et al.

Ingår i Journal of Microbiological Methods, s. 69-75, 2017

• DOI för Evaluation of automated time-lapse microscopy for assessment of in vitro activity of antibiotics

A whole-body physiologically based pharmacokinetic (WB-PBPK) model of ciprofloxacin: a step towards predicting bacterial killing at sites of infection.

Sadiq, Muhammad W; Nielsen, Elisabet I.; Khachman, Dalia; Conil, Jean-Marie et al.

Ingår i Journal of Pharmacokinetics and Pharmacodynamics, s. 69-79, 2017

• DOI för A whole-body physiologically based pharmacokinetic (WB-PBPK) model of ciprofloxacin: a step towards predicting bacterial killing at sites of infection.
• Ladda ner fulltext (pdf) av A whole-body physiologically based pharmacokinetic (WB-PBPK) model of ciprofloxacin: a step towards predicting bacterial killing at sites of infection.

Population Pharmacokinetic Modeling as a Tool To Characterize the Decrease in Ciprofloxacin Free Interstitial Levels Caused by Pseudomonas aeruginosa Biofilm Lung Infection in Wistar Rats

Torres, Bruna G. S.; Helfer, Victoria E.; Bernardes, Priscila M.; Macedo, Alexandre Jose et al.

Ingår i Antimicrobial Agents and Chemotherapy, 2017

• DOI för Population Pharmacokinetic Modeling as a Tool To Characterize the Decrease in Ciprofloxacin Free Interstitial Levels Caused by Pseudomonas aeruginosa Biofilm Lung Infection in Wistar Rats

A non-fatal intoxication and seven deaths involving the dissociative drug 3-MeO-PCP

Johansson, Anna; Lindstedt, Daniel; Roman, Markus; Thelander, Gunilla et al.

Ingår i Forensic Science International, s. 76-82, 2017

• DOI för A non-fatal intoxication and seven deaths involving the dissociative drug 3-MeO-PCP

Dynamic interaction of colistin and meropenem on a WT and a resistant strain of Pseudomonas aeruginosa as quantified in a PK/PD model

Mohamed, Ami F; Kristoffersson, Anders; Karvanen, Matti; Nielsen, Elisabet et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 1279-1290, 2016

• DOI för Dynamic interaction of colistin and meropenem on a WT and a resistant strain of Pseudomonas aeruginosa as quantified in a PK/PD model

A pharmacokinetic-pharmacodynamic (PKPD) model based on in vitro time-kill data predicts the in vivo PK/PD index of colistin

Khan, David D.; Friberg, Lena E.; Nielsen, Elisabet I.

Ingår i Journal of Antimicrobial Chemotherapy, s. 1881-1884, 2016

• DOI för A pharmacokinetic-pharmacodynamic (PKPD) model based on in vitro time-kill data predicts the in vivo PK/PD index of colistin

Population Pharmacokinetics of Plasma-Derived Factor IX: Procedures for Dose Individualization

Brekkan, Ari; Berntorp, Erik; Jensen, Kirsten; Nielsen, Elisabet I et al.

Ingår i Journal of Thrombosis and Haemostasis, s. 724-732, 2016

• DOI för Population Pharmacokinetics of Plasma-Derived Factor IX: Procedures for Dose Individualization

A pharmacokinetic-pharmacodynamic model characterizing the emergence of resistant Escherichia coli subpopulations during ertapenem exposure

Ungphakorn, Wanchana; Tängdén, Thomas; Sandegren, Linus; Nielsen, Elisabet I.

Ingår i Journal of Antimicrobial Chemotherapy, s. 2521-2533, 2016

• DOI för A pharmacokinetic-pharmacodynamic model characterizing the emergence of resistant Escherichia coli subpopulations during ertapenem exposure

Simulation-Based Evaluation of PK/PD Indices for Meropenem Across Patient Groups and Experimental Designs

Kristoffersson, Anders; David-Pierson, Pascale; Parrott, Neil J; Kuhlmann, Olaf et al.

Ingår i Pharmaceutical research, s. 1115-1125, 2016

• DOI för Simulation-Based Evaluation of PK/PD Indices for Meropenem Across Patient Groups and Experimental Designs

Development and Evaluation of a Gentamicin Pharmacokinetic Model That Facilitates Opportunistic Gentamicin Therapeutic Drug Monitoring in Neonates and Infants

Germovsek, Eva; Kent, Alison; Metsvaht, Tuuli; Lutsar, Irja et al.

Ingår i Antimicrobial Agents and Chemotherapy, s. 4869-4877, 2016

• DOI för Development and Evaluation of a Gentamicin Pharmacokinetic Model That Facilitates Opportunistic Gentamicin Therapeutic Drug Monitoring in Neonates and Infants

A mechanism-based pharmacokinetic/pharmacodynamic model allows prediction of antibiotic killing from MIC values for WT and mutants

Khan, David D.; Lagerbäck, Pernilla; Cao, Sha; Lustig, Ulrika et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 3051-3060, 2015

• DOI för A mechanism-based pharmacokinetic/pharmacodynamic model allows prediction of antibiotic killing from MIC values for WT and mutants

A Neonatal Amikacin Covariate Model Can Be Used to Predict Ontogeny of Other Drugs Eliminated Through Glomerular Filtration in Neonates

De Cock, Roosmarijn F W; Allegaert, Karel; Sherwin, Catherine M T; Nielsen, Elisabet I et al.

Ingår i Pharmaceutical research, s. 754-767, 2014

• DOI för A Neonatal Amikacin Covariate Model Can Be Used to Predict Ontogeny of Other Drugs Eliminated Through Glomerular Filtration in Neonates

Population pharmacokinetics of plasma-derived factor IX

Jensen, Kirsten; Jönsson, Siv; Nielsen, Elisabet I.; Berntorp, Erik

Ingår i Haemophilia, s. 80-80, 2014

Population pharmacokinetics of daptomycin in patients affected by severe Gram-positive infections

Di Paolo, Antonello; Tascini, Carlo; Polillo, Marialuisa; Gemignani, Giulia et al.

Ingår i International Journal of Antimicrobial Agents, s. 250-255, 2013

• DOI för Population pharmacokinetics of daptomycin in patients affected by severe Gram-positive infections

PK/PD Index Versus Mechanism-Based PKPD Modeling to Describe Antibacterial Efficacy of Ciprofloxacin and Colistin

Khan, David; Friberg, Lena E.; Nielsen, Elisabet I.

Ingår i Journal of Pharmacokinetics and Pharmacodynamics, 2013

Pharmacokinetic-pharmacodynamic model for gentamicin and its adaptive resistance with predictions of dosing schedules in newborn infants

Mohamed, Ami F; Nielsen, Elisabet I; Cars, Otto; Friberg, Lena E

Ingår i Antimicrobial Agents and Chemotherapy, s. 179-188, 2012

• DOI för Pharmacokinetic-pharmacodynamic model for gentamicin and its adaptive resistance with predictions of dosing schedules in newborn infants

Pharmacokinetic/Pharmacodynamic (PK/PD) indices of antibiotics predicted by a semi-mechanistic PKPD model: a step toward model-based dose optimization

Nielsen, Elisabet I; Cars, Otto; Friberg, Lena E

Ingår i Antimicrobial Agents and Chemotherapy, s. 4619-4630, 2011

• DOI för Pharmacokinetic/Pharmacodynamic (PK/PD) indices of antibiotics predicted by a semi-mechanistic PKPD model: a step toward model-based dose optimization

Predicting in vitro antibacterial efficacy across experimental designs with a semimechanistic pharmacokinetic-pharmacodynamic model

Nielsen, Elisabet I.; Cars, Otto; Friberg, Lena E.

Ingår i Antimicrobial Agents and Chemotherapy, s. 1571-1579, 2011

• DOI för Predicting in vitro antibacterial efficacy across experimental designs with a semimechanistic pharmacokinetic-pharmacodynamic model

Developmental Pharmacokinetics of Gentamicin in Preterm and Term Neonates: Population Modelling of a Prospective Study

Nielsen, Elisabet I.; Sandström, Marie; Honore, Per Hartvig; Ewald, Uwe et al.

Ingår i Clinical Pharmacokinetics, s. 253-263, 2009

• DOI för Developmental Pharmacokinetics of Gentamicin in Preterm and Term Neonates: Population Modelling of a Prospective Study

Semimechanistic pharmacokinetic/pharmacodynamic model for assessment of activity of antibacterial agents from time-kill curve experiments

Nielsen, Elisabet I.; Viberg, Anders; Löwdin, Elisabeth; Cars, Otto et al.

Ingår i Antimicrobial Agents and Chemotherapy, s. 128-136, 2007

• DOI för Semimechanistic pharmacokinetic/pharmacodynamic model for assessment of activity of antibacterial agents from time-kill curve experiments

Direct analysis of artemisinin in plasma and saliva using coupled-column high-performance liquid chromatography with a restricted-access material pre-column

Gordi, Toufigh; Nielsen, Elisabet I; Yu, Zuoxiang; Westerlund, Douglas et al.

Ingår i Journal of Chromatography B, s. 155-162, 2000

• DOI för Direct analysis of artemisinin in plasma and saliva using coupled-column high-performance liquid chromatography with a restricted-access material pre-column

Relationship between factor VIII activity, bleeds and individual characteristics in severe hemophilia A patients

Abrantes, João; Solms, Alexander; Garmann, Dirk; Nielsen, Elisabet I. et al.

Simulation-based evaluation of PK/PD indices for meropenem across patient groups and experimental designs

Kristoffersson, Anders; David-Pierson, Pascale; Parrott, Neil; Kuhlmann, Olaf et al.

The pharmacokinetics of antibiotics in patients with obesity: a systematic review and consensus guidelines for dose adjustments

Martson, Anne-Grete; Barber, Katie E.; Crass, Ryan L.; Hites, Maya et al.

Ingår i The Lancet - Infectious diseases, 2025

• DOI för The pharmacokinetics of antibiotics in patients with obesity: a systematic review and consensus guidelines for dose adjustments

From Therapeutic Drug Monitoring to Model-Informed Precision Dosing for Antibiotic

Wicha, Sebastian G.; Martson, Anne-Grete; Nielsen, Elisabet I.; Koch, Birgit C. P. et al.

Ingår i Clinical Pharmacology and Therapeutics, s. 928-941, 2021

• DOI för From Therapeutic Drug Monitoring to Model-Informed Precision Dosing for Antibiotic

Semi-mechanistic pharmacokinetic-pharmacodynamic modelling of antibiotic drug combinations

Brill, Margreke J. E.; Kristoffersson, Anders; Zhao, Chenyan; Nielsen, Elisabet I. et al.

Ingår i Clinical Microbiology and Infection, s. 697-706, 2018

• DOI för Semi-mechanistic pharmacokinetic-pharmacodynamic modelling of antibiotic drug combinations

The role of infection models and PK/PD modelling for optimising care of critically ill patients with severe infections

Tängdén, Thomas; Martin, V. Ramos; Felton, T. W.; Nielsen, Elisabet I. et al.

Ingår i Intensive Care Medicine, s. 1021-1032, 2017

• DOI för The role of infection models and PK/PD modelling for optimising care of critically ill patients with severe infections

Pharmacokinetic-Pharmacodynamic Modeling of Antibacterial Drugs

Nielsen, Elisabet I.; Friberg, Lena E.

Ingår i Pharmacological Reviews, s. 1053-1090, 2013

• DOI för Pharmacokinetic-Pharmacodynamic Modeling of Antibacterial Drugs

Pharmacometric Models for Antibacterial Agents to Improve Dosing Strategies

Nielsen, Elisabet I

2011

• Ladda ner fulltext (pdf) av Pharmacometric Models for Antibacterial Agents to Improve Dosing Strategies

Endotoxin challenge models: Model-based translation from piglets to healthy volunteers

Thorsted, Anders; Nielsen, Elisabet I.; Benson, Sven; Lipcsey, Miklós et al.

Model-based assessment of neutrophil-mediated phagocytosis and digeston of bacteria across in vitro and in vivo studies

Pham, Anh Duc; Thorsted, Anders; Friberg, Lena; Nielsen, Elisabet I.

Physiological response to endotoxin: Linking hemodynamic and respiratory longitudinal changes through modelling

Thorsted, Anders; Wang, Wenyi; Lipcsey, Miklós; Sjölin, Jan et al.

Translational PKPD modelling and simulation framework to explore the combined effect of polymyxin B and minocycline against Klebsiella pneumoniae

Zhao, Chenyan; van den Berg, Sanne; Wang, Zhigang; Olsson, Anna et al.

A framework to assess antibiotic effects using time-lapse microscopy

Wehrhahn, Eva; Zhao, Chenyan; Wistrand-Yuen, Pikkei; Brill, Margreke et al.

Pharmacokinetic-pharmacodynamic modelling to evaluate the relative impact of immune response and meropenem on bacterial killing in vivo

Saporta, Raphaël; Tassi, Natália; Biordi, Veronica; Ticha, Olga et al.

Impact of immune response on afabicin activity in an immunocompetent mouse thigh infection model quantified with a model-based approach

Saporta, Raphaël; Nielsen, Elisabet I.; Menetrey, Annick; Cameron, David R. et al.

Modelling antibiotic PKPD in a lung-mimicking transwell model

Bahnasawy, Salma M.; Swart, A. Leoni; Okujava, Rusudan; Bissantz, Caterina et al.