Pontus Aspenström

Miro GTPases at the Crossroads of Cytoskeletal Dynamics and Mitochondrial Trafficking

Aspenström, Pontus

Ingår i Cells, 2024

• DOI för Miro GTPases at the Crossroads of Cytoskeletal Dynamics and Mitochondrial Trafficking
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MTSS1: beyond the integration of actin and membrane dynamics

Matskova, Liudmila; Zheng, Shixing; Kashuba, Elena; Ernberg, Ingemar et al.

Ingår i Cellular and Molecular Life Sciences (CMLS), 2024

• DOI för MTSS1: beyond the integration of actin and membrane dynamics
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Diabetes compromises tight junction protein claudin 14 in the urinary bladder

Mohanty, Soumitra; White, John Kerr; Scheffschick, Andrea; Fischer, Berenice et al.

Ingår i Cell and Tissue Research, s. 27-33, 2024

• DOI för Diabetes compromises tight junction protein claudin 14 in the urinary bladder
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MTSS1 is downregulated in nasopharyngeal carcinoma (NPC) which disrupts adherens junctions leading to enhanced cell migration and invasion

Zheng, Shixing; Wang, Xiaoxia; Matskova, Liudmila; Zhou, Xiaoying et al.

Ingår i Frontiers in Cell and Developmental Biology, 2023

• DOI för MTSS1 is downregulated in nasopharyngeal carcinoma (NPC) which disrupts adherens junctions leading to enhanced cell migration and invasion
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The Role of Fast-Cycling Atypical RHO GTPases in Cancer

Aspenström, Pontus

Ingår i Cancers, 2022

• DOI för The Role of Fast-Cycling Atypical RHO GTPases in Cancer
• Ladda ner fulltext (pdf) av The Role of Fast-Cycling Atypical RHO GTPases in Cancer

Diabetes compromises tight junction protein claudin 14 in the urinary bladder

Mohanty, Soumitra; White, John Kerr; Scheffschick, Andrea; Fischer, Berenice et al.

Ingår i Cell and Tissue Research, s. 27-33, 2024

• DOI för Diabetes compromises tight junction protein claudin 14 in the urinary bladder
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MTSS1 is downregulated in nasopharyngeal carcinoma (NPC) which disrupts adherens junctions leading to enhanced cell migration and invasion

Zheng, Shixing; Wang, Xiaoxia; Matskova, Liudmila; Zhou, Xiaoying et al.

Ingår i Frontiers in Cell and Developmental Biology, 2023

• DOI för MTSS1 is downregulated in nasopharyngeal carcinoma (NPC) which disrupts adherens junctions leading to enhanced cell migration and invasion
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Altered cytoskeletal status in the transition from proneural to mesenchymal glioblastoma subtypes

Keller, Maureen; Blom, Magdalena; Liu Conze, Lei; Guo, Min et al.

Ingår i Scientific Reports, 2022

• DOI för Altered cytoskeletal status in the transition from proneural to mesenchymal glioblastoma subtypes
• Ladda ner fulltext (pdf) av Altered cytoskeletal status in the transition from proneural to mesenchymal glioblastoma subtypes

Diabetes downregulates the antimicrobial peptide psoriasin and increases E. coli burden in the urinary bladder

Mohanty, Soumitra; Kamolvit, Witchuda; Scheffschick, Andrea; Björklund, Anneli et al.

Ingår i Nature Communications, 2022

• DOI för Diabetes downregulates the antimicrobial peptide psoriasin and increases E. coli burden in the urinary bladder
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Palmdelphin Regulates Nuclear Resilience to Mechanical Stress in the Endothelium

Sainz-Jaspeado, Miguel; Smith, Ross O.; Plunde, Oscar; Pawelzik, Sven-Christian et al.

Ingår i Circulation, s. 1629-1645, 2021

• DOI för Palmdelphin Regulates Nuclear Resilience to Mechanical Stress in the Endothelium
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Syndecan-1 Overexpressing Mesothelioma Cells Inhibit Proliferation, Wound Healing, and Tube Formation of Endothelial Cells

Javadi, Joman; Heidari-Hamedani, Ghazal; Schmalzl, Angelika; Szatmari, Tunde et al.

Ingår i Cancers, 2021

• DOI för Syndecan-1 Overexpressing Mesothelioma Cells Inhibit Proliferation, Wound Healing, and Tube Formation of Endothelial Cells
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Cytoskeletal Organization Correlates to Motility and Invasiveness of Malignant Mesothelioma Cells

Keller, Maureen; Reis, Katarina; Hjerpe, Anders; Dobra, Katalin et al.

Ingår i Cancers, 2021

• DOI för Cytoskeletal Organization Correlates to Motility and Invasiveness of Malignant Mesothelioma Cells
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Inhibitors of cytoskeletal dynamics in malignant mesothelioma.

Reis, Katarina; Arbiser, Jack L; Hjerpe, Anders; Dobra, Katalin et al.

Ingår i Oncotarget, s. 4637-4647, 2020

• DOI för Inhibitors of cytoskeletal dynamics in malignant mesothelioma.
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The Intrinsic GDP/GTP Exchange Activities of Cdc42 and Rac1 Are A Critical Determinants for Their Specific Effects on Mobilization of the Actin Filament System

Aspenström, Pontus

Ingår i Cells, 2019

• DOI för The Intrinsic GDP/GTP Exchange Activities of Cdc42 and Rac1 Are A Critical Determinants for Their Specific Effects on Mobilization of the Actin Filament System
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WAFL, a new protein involved in regulation of early endocytictransport at the intersection of actin and microtubule dynamics

Viklund, Ing-Marie; Aspenström, Pontus; Meas-Yedid, Vannary; Zhang, Bo et al.

Ingår i Experimental Cell Research, s. 1040-1052, 2009

• DOI för WAFL, a new protein involved in regulation of early endocytictransport at the intersection of actin and microtubule dynamics

Miro1 is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses.

MacAskill, Andrew F.; Rinholm, Johanne E.; Twelvetrees, Alison E.; Arancibia-Carcamo, I. Lorena et al.

Ingår i Neuron, s. 541-555, 2009

• DOI för Miro1 is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses.

Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase

Saotome, Masao; Safiulina, Dzhamilja; Szabadkai, György; Das, Sudipto et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 20728-20733, 2008

• DOI för Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase

Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes--evidence for an autoregulatory mechanism

Berthold, Jessica; Schenková, Kristína; Ramos, Sonia; Miura, Yoshie et al.

Ingår i Experimental Cell Research, s. 3453-3465, 2008

• DOI för Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes--evidence for an autoregulatory mechanism

The atypical Rho GTPase Wrch1 collaborates with the nonreceptor tyrosine kinases Pyk2 and Src in regulating cytoskeletal dynamics

Ruusala, Aino; Aspenström, Pontus

Ingår i Molecular and Cellular Biology, s. 1802-14, 2008

• DOI för The atypical Rho GTPase Wrch1 collaborates with the nonreceptor tyrosine kinases Pyk2 and Src in regulating cytoskeletal dynamics

Oleic acid and docosahexaenoic acid cause an increase in the paracellular absorption of hydrophilic compounds in an experimental model of human absorptive enterocytes

Aspenström-Fagerlund, Bitte; Ring, Linda; Aspenström, Pontus; Tallkvist, Jonas et al.

Ingår i Toxicology, s. 12-23, 2007

• DOI för Oleic acid and docosahexaenoic acid cause an increase in the paracellular absorption of hydrophilic compounds in an experimental model of human absorptive enterocytes

Angiomotin regulates endothelial cell migration during embryonic angiogenesis

Aase, Karin; Ernkvist, Mira; Ebarasi, Lwaki; Jakobsson, Lars et al.

Ingår i Genes & Development, s. 2055-2068, 2007

• DOI för Angiomotin regulates endothelial cell migration during embryonic angiogenesis

The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics

Aspenström, Pontus; Richnau, Ninna; Johansson, Ann-Sofi

Ingår i Experimental Cell Research, s. 2180-2194, 2006

• DOI för The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics

Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis

Edlund, Sofia; Lee, So Young; Grimsby, Susanne; Zhang, Shouthing et al.

Ingår i Molecular and Cellular Biology, s. 1475-1488, 2005

• DOI för Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis

Smad7 is required for TGF-ß-induced activation of the small GTPase Cdc42

Edlund, Sofia; Landström, Maréne; Heldin, Carl-Henrik; Aspenström, Pontus

Ingår i Journal of Cell Science, s. 1835-1847, 2004

• DOI för Smad7 is required for TGF-ß-induced activation of the small GTPase Cdc42

A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity

Chiara, Federica; Goumans, Marie-José; Forsberg, Henrik; Åhgrén, Aive et al.

Ingår i Journal of Biological Chemistry, s. 42516-42527, 2004

• DOI för A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity

The mammalian verprolin homologue WIRE participates in receptor-mediated endocytosis and regulation of the actin filament system by distinct mechanisms

Aspenström, Pontus

Ingår i Experimental Cell Research, s. 485-498, 2004

• DOI för The mammalian verprolin homologue WIRE participates in receptor-mediated endocytosis and regulation of the actin filament system by distinct mechanisms

Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons

Lundström, Annika; Gallio, Marco; Englund, Camilla; Steneberg, Pär et al.

Ingår i Genes & Development, s. 2161-2171, 2004

• DOI för Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons

Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology

Ruusala, Aino; Aspenström, Pontus

Ingår i FEBS Letters, s. 159-166, 2004

• DOI för Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology

Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways

Jaffe, Aron B; Aspenström, Pontus; Hall, Alan

Ingår i Molecular and Cellular Biology, s. 1736-1746, 2004

• DOI för Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways

Rho GTPases have diverse effects on the organization of the actin filament system

Aspenström, Pontus; Fransson, Åsa; Saras, Jan

Ingår i Biochemical Journal, s. 327-337, 2004

RICH-1 has a BIN/Amphiphysin/Rvsp domain responsible for binding to membrane lipids and tubulation of liposomes

Richnau, Ninna; Fransson, Åsa; Farsad, Khashayar; Aspenström, Pontus

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 1034-1042, 2004

• DOI för RICH-1 has a BIN/Amphiphysin/Rvsp domain responsible for binding to membrane lipids and tubulation of liposomes

Wrch1 is a GTPase-deficient Cdc42-like protein with unusual binding characteristics and cellular effects.

Saras, Jan; Wollberg, Patrick; Aspenström, Pontus

Ingår i Exp Cell Res, s. 356-69, 2004

Transforming Growth Factor-β1 (TGF-β)–induced Apoptosis of Prostate Cancer Cells Involves Smad7-dependent Activation of p38 by TGF-β-activated Kinase 1 and Mitogen-activated Protein Kinase Kinase 3

Edlund, Sofia; Bu, Shizhong; Schuster, Norbert; Aspenström, Pontus et al.

Ingår i Molecular Biology of the Cell, s. 529-544, 2003

• DOI för Transforming Growth Factor-β1 (TGF-β)–induced Apoptosis of Prostate Cancer Cells Involves Smad7-dependent Activation of p38 by TGF-β-activated Kinase 1 and Mitogen-activated Protein Kinase Kinase 3

Down-regulation of Rac activity during beta 2 integrin-mediated adhesion of human neutrophils

Dib, Karim; Melander, Fredrik; Axelsson, Lena; Dagher, Marie-Claire et al.

Ingår i Journal of Biological Chemistry, s. 24181-24188, 2003

• DOI för Down-regulation of Rac activity during beta 2 integrin-mediated adhesion of human neutrophils

Effect of transforming growth factor-beta on calcium homeostasis inprostate carcinoma cells.

Gizatullina, Zemfira Z.; Grapengiesser, Eva; Shabalina, Irina G.; Nedergaard, Jan et al.

Ingår i Biochem Biophys Res Commun, s. 643, 2003

Transforming Growth Factor-β–induced Mobilization of Actin Cytoskeleton Requires Signaling by Small GTPases Cdc42 and RhoA

Edlund, Sofia; Landström, Maréne; Heldin, Carl-Henrik; Aspenström, Pontus

Ingår i Molecular Biology of the Cell, s. 902-914, 2002

• DOI för Transforming Growth Factor-β–induced Mobilization of Actin Cytoskeleton Requires Signaling by Small GTPases Cdc42 and RhoA

The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor

Aspenström, Pontus

Ingår i Experimental Cell Research, s. 21-33, 2002

• DOI för The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor

Cdc42, Rac1, and the Wiskott-Aldrich syndrome protein are involved in the cytoskeletal regulation of B lymphocytes.

Westerberg, Lisa; Greicius, Gediminas; Snapper, Scott B.; Aspenström, Pontus et al.

Ingår i Blood, s. 1086-1094, 2001

• DOI för Cdc42, Rac1, and the Wiskott-Aldrich syndrome protein are involved in the cytoskeletal regulation of B lymphocytes.

Miro GTPases at the Crossroads of Cytoskeletal Dynamics and Mitochondrial Trafficking

Aspenström, Pontus

Ingår i Cells, 2024

• DOI för Miro GTPases at the Crossroads of Cytoskeletal Dynamics and Mitochondrial Trafficking
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MTSS1: beyond the integration of actin and membrane dynamics

Matskova, Liudmila; Zheng, Shixing; Kashuba, Elena; Ernberg, Ingemar et al.

Ingår i Cellular and Molecular Life Sciences (CMLS), 2024

• DOI för MTSS1: beyond the integration of actin and membrane dynamics
• Ladda ner fulltext (pdf) av MTSS1: beyond the integration of actin and membrane dynamics

The Role of Fast-Cycling Atypical RHO GTPases in Cancer

Aspenström, Pontus

Ingår i Cancers, 2022

• DOI för The Role of Fast-Cycling Atypical RHO GTPases in Cancer
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Activated Rho GTPases in Cancer-The Beginning of a New Paradigm

Aspenström, Pontus

Ingår i International Journal of Molecular Sciences, 2018

• DOI för Activated Rho GTPases in Cancer-The Beginning of a New Paradigm
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Roles of F-BAR/PCH Proteins in the Regulation of Membrane Dynamics and Actin Reorganization

Aspenström, Pontus

Ingår i International Review of Cell and Molecular Biology, s. 1-31, 2009

• DOI för Roles of F-BAR/PCH Proteins in the Regulation of Membrane Dynamics and Actin Reorganization

Taking Rho GTPases to the next level: the cellular functions of atypical Rho GTPases

Aspenström, Pontus; Ruusala, Aino; Pacholsky, Dirk

Ingår i Experimental Cell Research, s. 3673-3679, 2007

• DOI för Taking Rho GTPases to the next level: the cellular functions of atypical Rho GTPases

Pombe Cdc15 homology proteins: regulators of membrane dynamics and the actin cytoskeleton

Aspenström, Pontus; Fransson, Åsa; Richnau, Ninna

Ingår i TIBS -Trends in Biochemical Sciences. Regular ed., s. 670-679, 2006

• DOI för Pombe Cdc15 homology proteins: regulators of membrane dynamics and the actin cytoskeleton

The verprolin family of proteins: Regulators of cell morphogenesis and endocytosis

Aspenström, Pontus

Ingår i FEBS Letters, s. 5253-5259, 2005

• DOI för The verprolin family of proteins: Regulators of cell morphogenesis and endocytosis

Integration of signalling pathways regulated by small GTPases and calcium

Aspenström, Pontus

Ingår i Biochimica et Biophysica Acta, s. 51-58, 2004

• DOI för Integration of signalling pathways regulated by small GTPases and calcium

The verprolins as regulators of actin dynamics.

Aspenström, Pontus

Ingår i Actin-monomer-binding proteins., s. 97-106, Landes Biosciences, 2006

• DOI för The verprolins as regulators of actin dynamics.