Ulf Lindahl

Interacting polymer-modification enzymes in heparan sulfate biosynthesis

Zhang, Tianji; Yu, Mingjia; Li, Honglian; Maccarana, Marco et al.

Ingår i Carbohydrate Polymers, 2023

• DOI för Interacting polymer-modification enzymes in heparan sulfate biosynthesis

Heparanase overexpression impedes perivascular clearance of amyloid-beta from murine brain: relevance to Alzheimer's disease

Zhang, Xiao; O'Callaghan, Paul; Li, Honglian; Tan, Ying-Xia et al.

Ingår i Acta neuropathologica communications, 2021

• DOI för Heparanase overexpression impedes perivascular clearance of amyloid-beta from murine brain: relevance to Alzheimer's disease
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Heparin: An old drug with multiple potential targets in Covid-19 therapy

Lindahl, Ulf; Li, Jin-Ping

Ingår i Journal of Thrombosis and Haemostasis, s. 2422-2424, 2020

• DOI för Heparin: An old drug with multiple potential targets in Covid-19 therapy

Heparanase: Discovery and Targets

Lindahl, Ulf; Li, Jin-Ping

Ingår i Heparanase, s. 61-69, Springer, 2020

• DOI för Heparanase: Discovery and Targets

Specificity of glycosaminoglycan-protein interactions

Kjellén, Lena; Lindahl, Ulf

Ingår i Current opinion in structural biology, s. 101-108, 2018

• DOI för Specificity of glycosaminoglycan-protein interactions

Interacting polymer-modification enzymes in heparan sulfate biosynthesis

Zhang, Tianji; Yu, Mingjia; Li, Honglian; Maccarana, Marco et al.

Ingår i Carbohydrate Polymers, 2023

• DOI för Interacting polymer-modification enzymes in heparan sulfate biosynthesis

Heparanase overexpression impedes perivascular clearance of amyloid-beta from murine brain: relevance to Alzheimer's disease

Zhang, Xiao; O'Callaghan, Paul; Li, Honglian; Tan, Ying-Xia et al.

Ingår i Acta neuropathologica communications, 2021

• DOI för Heparanase overexpression impedes perivascular clearance of amyloid-beta from murine brain: relevance to Alzheimer's disease
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Heparin: An old drug with multiple potential targets in Covid-19 therapy

Lindahl, Ulf; Li, Jin-Ping

Ingår i Journal of Thrombosis and Haemostasis, s. 2422-2424, 2020

• DOI för Heparin: An old drug with multiple potential targets in Covid-19 therapy

Specificity of glycosaminoglycan-protein interactions

Kjellén, Lena; Lindahl, Ulf

Ingår i Current opinion in structural biology, s. 101-108, 2018

• DOI för Specificity of glycosaminoglycan-protein interactions

A Potential Role for Chondroitin Sulfate/Dermatan Sulfate in Arm Regeneration in Amphiura filiformis.

Ramachandra, Rashmi; Namburi, Ramesh Babu; Dupont, Sam; Ortega-Martinez, Olga et al.

Ingår i Glycobiology, s. 438-449, 2017

• DOI för A Potential Role for Chondroitin Sulfate/Dermatan Sulfate in Arm Regeneration in Amphiura filiformis.

Enzyme overexpression - an exercise toward understanding regulation of heparan sulfate biosynthesis

Fang, Jianping; Song, Tianyi; Lindahl, Ulf; Li, Jin-Ping

Ingår i Scientific Reports, 2016

• DOI för Enzyme overexpression - an exercise toward understanding regulation of heparan sulfate biosynthesis
• Ladda ner fulltext (pdf) av Enzyme overexpression - an exercise toward understanding regulation of heparan sulfate biosynthesis

Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response

O'Callaghan, Paul; Li, Jin-Ping; Lannfelt, Lars; Lindahl, Ulf et al.

Ingår i Journal of Biological Chemistry, s. 14904-14914, 2015

• DOI för Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response

Apolipoprotein E increases cell association of amyloid-β 40 through heparan sulfate and LRP1 dependent pathways

O'Callaghan, Paul; Noborn, Fredrik; Sehlin, Dag; Li, Jin-ping et al.

Ingår i Amyloid, s. 76-87, 2014

• DOI för Apolipoprotein E increases cell association of amyloid-β 40 through heparan sulfate and LRP1 dependent pathways

A personal voyage through the proteoglycan field

Lindahl, Ulf

Ingår i Matrix Biology, s. 3-7, 2014

• DOI för A personal voyage through the proteoglycan field
• Ladda ner fulltext (pdf) av A personal voyage through the proteoglycan field

Brittlestars contain highly sulfated chondroitin sulfates/dermatan sulfates that promote fibroblast growth factor 2-induced cell signaling

Ramachandra, Rashmi; Namburi, Ramesh Babu; Ortega-Martinez, Olga; Shi, Xiaofeng et al.

Ingår i Glycobiology, s. 195-207, 2014

• DOI för Brittlestars contain highly sulfated chondroitin sulfates/dermatan sulfates that promote fibroblast growth factor 2-induced cell signaling

Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-beta in murine brain

Zhang, Xiao; Wang, Bo; O'Callaghan, Paul; Hjertstrom, Elina et al.

Ingår i Acta Neuropathologica, s. 465-478, 2012

• DOI för Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-beta in murine brain

Heparanase Affects Food Intake and Regulates Energy Balance in Mice

Karlsson-Lindahl, Linda; Schmidt, Linnea; Haage, David; Hansson, Caroline et al.

Ingår i PLOS ONE, 2012

• DOI för Heparanase Affects Food Intake and Regulates Energy Balance in Mice
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Drosophila heparan sulfate: a novel design

Kusche-Gullberg, Marion; Nybakken, Kent; Perrimon, Norbert; Lindahl, Ulf

Ingår i Journal of Biological Chemistry, s. 21950-21956, 2012

• DOI för Drosophila heparan sulfate: a novel design

Low dose of the liver X receptor agonist, AZ876, reduces atherosclerosis in APOE*3Leiden mice without affecting liver or plasma triglyceride levels

van der Hoorn, Jwa; Lindén, D; Lindahl, Ulf; Bekkers, Mea et al.

Ingår i British Journal of Pharmacology, s. 1553-1563, 2011

• DOI för Low dose of the liver X receptor agonist, AZ876, reduces atherosclerosis in APOE*3Leiden mice without affecting liver or plasma triglyceride levels

Heparan sulfate mediates amyloid-beta internalization and cytotoxicity

Sandwall, Elina; O'Callaghan, Paul; Zhang, Xiao; Lindahl, Ulf et al.

Ingår i Glycobiology, s. 533-541, 2010

• DOI för Heparan sulfate mediates amyloid-beta internalization and cytotoxicity

Heparan Sulfate Domain Organization and Sulfation Modulate FGF-induced Cell Signaling

Jastrebova, Nadja; Vanwildemeersch, Maarten; Lindahl, Ulf; Spillmann, Dorothe

Ingår i Journal of Biological Chemistry, s. 26842-26851, 2010

• DOI för Heparan Sulfate Domain Organization and Sulfation Modulate FGF-induced Cell Signaling

Low molecular weight heparin stimulates myometrial contractility and cervical remodeling in vitro

Ekman-Ordeberg, Gunvor; Hellgren, Margareta; Akerud, Anna; Andersson, Eva et al.

Ingår i Acta Obstetricia et Gynecologica Scandinavica, s. 984-989, 2009

• DOI för Low molecular weight heparin stimulates myometrial contractility and cervical remodeling in vitro

Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases

Zcharia, Eyal; Jia, Juan; Zhang, Xiao; Baraz, Lea et al.

Ingår i PLoS ONE, 2009

• DOI för Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases

Lack of L-iduronic acid in heparan sulfate affects interaction with growth factors and cell signaling

Jia, Juan; Maccarana, Marco; Zhang, Xiao; Bespalov, Maxim et al.

Ingår i Journal of Biological Chemistry, s. 15942-15950, 2009

• DOI för Lack of L-iduronic acid in heparan sulfate affects interaction with growth factors and cell signaling

Heparin/heparan sulfate biosynthesis: Processive formation of N-sulfated domains

Carlsson, Pernilla; Presto, Jenny; Spillmann, Dorothe; Lindahl, Ulf et al.

Ingår i Journal of Biological Chemistry, s. 20008-20014, 2008

• DOI för Heparin/heparan sulfate biosynthesis: Processive formation of N-sulfated domains

Artificiell polysackarid gav kontaminerat heparin: Akuta överkänslighetsreaktioner får sin förklaring - men hur kunde det hända?

Lindahl, Ulf

Ingår i Läkartidningen, s. 2660-2661, 2008

Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells

O'Callaghan, Paul; Sandwall, Elina; Li, Jin-Ping; Yu, Hong et al.

Ingår i Brain Pathology, s. 548-561, 2008

• DOI för Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells

Heparan sulfate-protein interactions--a concept for drug design?

Lindahl, Ulf

Ingår i Thrombosis and Haemostasis, s. 109-115, 2007

• DOI för Heparan sulfate-protein interactions--a concept for drug design?

Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development

Abramsson, Alexandra; Kurup, Sindhulakshmi; Yamada, Shuhei; Lindblom, Per et al.

Ingår i Genes & Development, s. 316-331, 2007

• DOI för Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development

Characterization of anti-heparan sulfate phage display antibodies AO4B08 and HS4E4

Kurup, Sindhulakshmi; Wijnhoven, Tessa J M; Jenniskens, Guido J; Kimata, Koji et al.

Ingår i Journal of Biological Chemistry, s. 21032-21042, 2007

• DOI för Characterization of anti-heparan sulfate phage display antibodies AO4B08 and HS4E4

Surface-exposed amino acid residues of HPV16 L1 protein mediating interaction with cell surface heparan sulfate

Knappe, Maren; Bodevin, Sabrina; Selinka, Hans-Christoph; Spillmann, Dorothe et al.

Ingår i Journal of Biological Chemistry, s. 27913-27922, 2007

• DOI för Surface-exposed amino acid residues of HPV16 L1 protein mediating interaction with cell surface heparan sulfate

Transgenic or tumor-induced expression of heparanase upregulates sulfation of heparan sulfate

Escobar Galvis, Martha L.; Jia, Juan; Zhang, Xiao; Jastrebova, Nadja et al.

Ingår i Nature Chemical Biology, s. 773-778, 2007

• DOI för Transgenic or tumor-induced expression of heparanase upregulates sulfation of heparan sulfate

Heparan sulfate-related oligosaccharides in ternary complex formation with fibroblast growth factors 1 and 2 and their receptors

Jastrebova, Nadja; Vanwildemeersch, Maarten; Rapraeger, Alan; Gimenéz-Gallego, Guillermo et al.

Ingår i Journal of Biological Chemistry, s. 26884-26892, 2006

• DOI för Heparan sulfate-related oligosaccharides in ternary complex formation with fibroblast growth factors 1 and 2 and their receptors

Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment

Kurup, S; Abramsson, A; Li, Jin-Ping; Lindahl, Ulf et al.

Ingår i Biochemical Society Transactions, s. 454-455, 2006

3-O-sulfated oligosaccharide structures are recognized by anti-heparan sulfate antibody HS4C3.

Ten Dam, Gerdy B; Kurup, Sindhulakshmi; van de Westerlo, Els M A; Versteeg, Elly M M et al.

Ingår i J Biol Chem, s. 4654-62, 2006

Heparan sulfate C5-epimerase is essential for heparin biosynthesis in mast cells.

Feyerabend, Thorsten B; Li, Jin-Ping; Lindahl, Ulf; Rodewald, Hans-Reimer

Ingår i Nat Chem Biol, s. 195-6, 2006

Substrate specificity and domain functions of extracellular heparan sulfate 6-O-endosulfatases, QSulf1 and QSulf2.

Ai, Xingbin; Do, Anh-Tri; Kusche-Gullberg, Marion; Lindahl, Ulf et al.

Ingår i J Biol Chem, s. 4969-76, 2006

Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2.

Maccarana, Marco; Olander, Benny; Malmström, Johan; Tiedemann, Kerstin et al.

Ingår i J Biol Chem, s. 11560-8, 2006

In vivo fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosis

Li, Jin-Ping; Galvis, Martha L. Escobar; Gong, Feng; Zhang, Xiao et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 6473-7, 2005

• DOI för In vivo fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosis

Generation of "neoheparin" from E. coli K5 capsular polysaccharide.

Lindahl, Ulf; Li, Jin-Ping; Kusche-Gullberg, Marion; Salmivirta, Markku et al.

Ingår i J Med Chem, s. 349-52, 2005

Fibroblast growth factors share binding sites in heparan sulphate.

Kreuger, Johan; Jemth, Per; Sanders-Lindberg, Emil; Eliahu, Liat et al.

Ingår i Biochem J, s. 145-50, 2005

Biosynthesis of hyaluronan: direction of chain elongation.

Bodevin-Authelet, Sabrina; Kusche-Gullberg, Marion; Pummill, Philip E; DeAngelis, Paul L et al.

Ingår i J Biol Chem, s. 8813-8, 2005

Relative susceptibilities of the glucosamine-glucuronic acid and N-acetylglucosamine-glucuronic acid linkages to heparin lyase III.

Chai, Wengang; Leteux, Christine; Westling, Camilla; Lindahl, Ulf et al.

Ingår i Biochemistry, s. 8590-9, 2004

Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behavior.

Zcharia, Eyal; Metzger, Shula; Chajek-Shaul, Tova; Aingorn, Helena et al.

Ingår i FASEB J, s. 252-63, 2004

Irreversible glucuronyl C5-epimerization in the biosynthesis of heparan sulfate.

Hagner-McWhirter, Asa; Li, Jin-Ping; Oscarson, Stefan; Lindahl, Ulf

Ingår i J Biol Chem, s. 14631-8, 2004

Processing of macromolecular heparin by heparanase

Gong, Feng; Jemth, Per; Escobar Galvis, Martha L; Vlodavsky, Israel et al.

Ingår i Journal of Biological Chemistry, s. 35152-35158, 2003

• DOI för Processing of macromolecular heparin by heparanase

Oligosaccharide library-based assessment of heparan sulfate6-O-sulfotransferase substrate specificity.

Jemth, P; Smeds, E; Do, AT; Habuchi, H et al.

Ingår i J Biol Chem, s. 24371, 2003

Differential tyrosine phosphorylation of fibroblast growth factor (FGF) receptor-1 and receptor proximal signal transduction in response to FGF-2 and heparin.

Lundin, Lars; Rönnstrand, Lars; Cross, Michael; Hellberg, Carina et al.

Ingår i Exp Cell Res, s. 190-8, 2003

Biosynthetic oligosaccharide libraries for identification of protein-binding heparan sulfate motifs: exploring the structural diversity by screening for fibroblast growth factor (FGF)1 and FGF2 binding.

Jemth, Per; Kreuger, Johan; Kusche-Gullberg, Marion; Sturiale, Luisa et al.

Ingår i Journal of Biological Chemistry, s. 30567-30573, 2002

• DOI för Biosynthetic oligosaccharide libraries for identification of protein-binding heparan sulfate motifs: exploring the structural diversity by screening for fibroblast growth factor (FGF)1 and FGF2 binding.

Selectively desulfated heparin inhibits fibroblast growth factor-induced mitogenicity and angiogenesis.

Lundin, Lars; Larsson, Helena; Kreuger, Johan; Kanda, S et al.

Ingår i Journal of Biological Chemistry, s. 24653-24660, 2000

• DOI för Selectively desulfated heparin inhibits fibroblast growth factor-induced mitogenicity and angiogenesis.

Identification of O-sulphate substituents on D-glucuronic acid units in heparin-related glycosaminoglycans using novel synthetic disaccharide standards.

Razi, Nahid; Kreuger, Johan; Lay, L; Russo, G et al.

Ingår i Glycobiology, s. 807-811, 1995

• DOI för Identification of O-sulphate substituents on D-glucuronic acid units in heparin-related glycosaminoglycans using novel synthetic disaccharide standards.

Pathophysiology of heparan sulphate: many diseases, few drugs

Lindahl, Ulf; Kjellén, Lena

Ingår i Journal of Internal Medicine, s. 555-571, 2013

• DOI för Pathophysiology of heparan sulphate: many diseases, few drugs
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Interactions Between Heparan Sulfate and Proteins—Design and Functional Implications

Lindahl, Ulf; Li, Jin-ping

Ingår i International review of cell and molecular biology, s. 105-159, 2009

• DOI för Interactions Between Heparan Sulfate and Proteins—Design and Functional Implications

Interactions between heparan sulfate and proteins: the concept of specificity

Kreuger, Johan; Spillmann, Dorothe; Li, Jin-ping; Lindahl, Ulf

Ingår i Journal of Cell Biology, s. 323-327, 2006

Heparanase: Discovery and Targets

Lindahl, Ulf; Li, Jin-Ping

Ingår i Heparanase, s. 61-69, Springer, 2020

• DOI för Heparanase: Discovery and Targets

Remodeling of heparan sulfation by extracellular endosulfatases

Ai, X.; Kusche Gullberg, Marion; Lindahl, Ulf; Emerson, C.P. Jr.

Ingår i Chemistry and Biology of Heparin and Heparan Sulfate, Elsevier Science Ltd, 2006

Heparanase cleavage of heparin modulates protease storage in mast cells

Jia, Juan; Zhang, Xiao; Zcharia, Eyal; Vlodavsky, Israel et al.