Molecular Pharmaceutics

Impact of surfactants on solution behavior and membrane transport of amorphous solid dispersions

Alhalaweh, Amjad; El Sayed, Mira; Kovac, Lucia; Bergström, Christel A.S.

Part of Journal of Pharmaceutical Sciences, p. 458-467, 2025

• DOI for Impact of surfactants on solution behavior and membrane transport of amorphous solid dispersions
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Liquid crystal nanoparticles for oral combination antibiotic therapies: A strategy towards protecting commensal gut bacteria during treatment

He, Xiguo; Karlsson, Philip; Xiong, Ruisheng; Moodie, Lindon W. K. et al.

Part of Journal of Colloid and Interface Science, p. 287-300, 2025

• DOI for Liquid crystal nanoparticles for oral combination antibiotic therapies: A strategy towards protecting commensal gut bacteria during treatment
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Optimized Artificial Colonic Mucus Enabling Physiologically Relevant Diffusion Studies of Drugs, Particles, and Delivery Systems

Tjakra, Marco; Chakrapeesirisuk, Nopdanai; Jacobson, Magdalena; Sellin, Mikael E. et al.

Part of Molecular Pharmaceutics, 2025

• DOI for Optimized Artificial Colonic Mucus Enabling Physiologically Relevant Diffusion Studies of Drugs, Particles, and Delivery Systems
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Analysis of stabilization mechanisms in β-lactoglobulin-based amorphous solid dispersions by experimental and computational approaches

Zhuo, Xuezhi; Foderà, Vito; Larsson, Per; Schaal, Zarah et al.

Part of European Journal of Pharmaceutical Sciences, 2024

• DOI for Analysis of stabilization mechanisms in β-lactoglobulin-based amorphous solid dispersions by experimental and computational approaches
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Benefits of combining supersaturating and solubilizing formulations - Is two better than one?

Alvebratt, Caroline; Karlén, Filip; Åhlén, Michelle; Edueng, Khadijah et al.

Part of International Journal of Pharmaceutics, 2024

• DOI for Benefits of combining supersaturating and solubilizing formulations - Is two better than one?

Design, Synthesis, and Evaluation of New 1H-Benzo[d]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections

Soukarieh, Fadi; Mashabi, Alaa; Richardson, William; Oton, Eduard Vico et al.

Part of Journal of Medicinal Chemistry, p. 1008-1023, 2024

• DOI for Design, Synthesis, and Evaluation of New 1H-Benzo[d]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections
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Development and characterization of solid lipid-based formulations (sLBFs) of ritonavir utilizing a lipolysis and permeation assay

Schulzen, Arne; Andreadis, Ioannis I.; Bergström, Christel A. S.; Quodbach, Julian

Part of European Journal of Pharmaceutical Sciences, 2024

• DOI for Development and characterization of solid lipid-based formulations (sLBFs) of ritonavir utilizing a lipolysis and permeation assay
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Development of a canine artificial colonic mucus model for drug diffusion studies

Barmpatsalou, Vicky; Tjakra, Marco; Li, Lingxiao; Dubbelboer, Ilse R. et al.

Part of European Journal of Pharmaceutical Sciences, 2024

• DOI for Development of a canine artificial colonic mucus model for drug diffusion studies
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Drug solubilization in dog intestinal fluids with and without administration of lipid-rich formulations

Parrow, Albin; Kabedev, Aleksei; Larsson, Per; Johansson, Pernilla et al.

Part of Journal of Controlled Release, 2024

• DOI for Drug solubilization in dog intestinal fluids with and without administration of lipid-rich formulations
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Effect of Data Quality and Data Quantity on the Estimation of Intrinsic Solubility: Analysis Based on a Single-Source Data Set

Zhao, Jiaxi; Hermans, Eline; Sepassi, Kia; Tistaert, Christophe et al.

Part of Molecular Pharmaceutics, p. 5261-5271, 2024

• DOI for Effect of Data Quality and Data Quantity on the Estimation of Intrinsic Solubility: Analysis Based on a Single-Source Data Set
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Estimation of the concentration boundary layer adjacent to a flat surface using computational fluid dynamics

Sinko, Patrick D.; Parker, Louis; Prahl Wittberg, Lisa; Bergström, Christel A. S.

Part of International Journal of Pharmaceutics, 2024

• DOI for Estimation of the concentration boundary layer adjacent to a flat surface using computational fluid dynamics
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Excipient effects on supersaturation, particle size dynamics, and thermodynamic activity of multidrug amorphous formulations

El Sayed, Mira; Alhalaweh, Amjad; Kovac, Lucia; Bergström, Christel A.S.

Part of International Journal of Pharmaceutics, 2024

• DOI for Excipient effects on supersaturation, particle size dynamics, and thermodynamic activity of multidrug amorphous formulations

Molecular dynamics simulations of lipid composition and its impact on structural and dynamic properties of skin membrane

Altun, Diyar; Larsson, Per; Bergström, Christel; Hossain, Md Shakhawath

Part of Chemistry and Physics of Lipids, 2024

• DOI for Molecular dynamics simulations of lipid composition and its impact on structural and dynamic properties of skin membrane
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Molecular dynamics study on micelle-small molecule interactions: developing a strategy for an extensive comparison

Kabedev, Aleksei; Bergström, Christel A. S.; Larsson, Per

Part of Journal of Computer-Aided Molecular Design, 2024

• DOI for Molecular dynamics study on micelle-small molecule interactions: developing a strategy for an extensive comparison
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Development and validation of a porcine artificial colonic mucus model reflecting the properties of native colonic mucus in pigs

Barmpatsalou, Vicky; Rodler, Agnes; Jacobson, Magdalena; Karlsson, Eva Marie-Louise et al.

Part of European Journal of Pharmaceutical Sciences, 2023

• DOI for Development and validation of a porcine artificial colonic mucus model reflecting the properties of native colonic mucus in pigs
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Evaluation in pig of an intestinal administration device for oral peptide delivery

Berg, Staffan; Uggla, Teresia; Antonsson, Malin; Nunes, Sandro Filipe et al.

Part of Journal of Controlled Release, p. 792-801, 2023

• DOI for Evaluation in pig of an intestinal administration device for oral peptide delivery

Exploring the use of modified in vitro digestion assays for the evaluation of ritonavir loaded solid lipid-based formulations

Andreadis, Ioannis I.; Schulzen, Arne; Quodbach, Julian; Bergström, Christel

Part of European Journal of Pharmaceutical Sciences, 2023

• DOI for Exploring the use of modified in vitro digestion assays for the evaluation of ritonavir loaded solid lipid-based formulations
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Intrinsic lipolysis rate for systematic design of lipid-based formulations

Jacobsen, Ann-Christin; Kabedev, Aleksei; Sinko, Patrick D.; Palm, Johan E. et al.

Part of Drug Delivery and Translational Research, p. 1288-1304, 2023

• DOI for Intrinsic lipolysis rate for systematic design of lipid-based formulations
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Molecular Dynamics Simulations of Self-Assembling Colloids in Fed-State Human Intestinal Fluids and Their Solubilization of Lipophilic Drugs

Parrow, Albin; Larsson, Per; Augustijns, Patrick; Bergström, Christel A. S.

Part of Molecular Pharmaceutics, p. 451-460, 2023

• DOI for Molecular Dynamics Simulations of Self-Assembling Colloids in Fed-State Human Intestinal Fluids and Their Solubilization of Lipophilic Drugs
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Numerical simulation of peristalsis to study co-localization and intestinal distribution of a macromolecular drug and permeation enhancer

Naranjani, Benyamin; Sinko, Patrick D.; Bergström, Christel; Gogoll, A et al.

Part of International Journal of Biological Macromolecules, 2023

• DOI for Numerical simulation of peristalsis to study co-localization and intestinal distribution of a macromolecular drug and permeation enhancer
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Quality attributes for printable emulsion gels and 3D-printed tablets: Towards production of personalized dosage forms

Johannesson, Jenny; Wu, Mingjun; Johansson, Mathias; Bergström, Christel

Part of International Journal of Pharmaceutics, 2023

• DOI for Quality attributes for printable emulsion gels and 3D-printed tablets: Towards production of personalized dosage forms

Synergistic stabilization of emulsion gel by nanoparticles and surfactant enables 3D printing of lipid-rich solid oral dosage forms

Johannesson, Jenny; Pathare, Malhar Manik; Johansson, Mathias; Bergström, Christel et al.

Part of Journal of Colloid and Interface Science, p. 1253-1264, 2023

• DOI for Synergistic stabilization of emulsion gel by nanoparticles and surfactant enables 3D printing of lipid-rich solid oral dosage forms
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Bioavailability of Celecoxib Formulated with Mesoporous Magnesium Carbonate: An In Vivo Evaluation

Zardán Gómez de la Torre, Teresa; Lindmark, Tuulikki; Cheung, Ocean; Bergström, Christel et al.

Part of Molecules, 2022

• DOI for Bioavailability of Celecoxib Formulated with Mesoporous Magnesium Carbonate: An In Vivo Evaluation
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Comparison of cellular monolayers and an artificial membrane as absorptive membranes in the in vitro lipolysis-permeation assay

Keemink, Janneke; Hedge, Oliver; Bianco, Valentina; Hubert, Madlen et al.

Part of Journal of Pharmaceutical Sciences, p. 175-184, 2022

• DOI for Comparison of cellular monolayers and an artificial membrane as absorptive membranes in the in vitro lipolysis-permeation assay
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Considerations in the developability of peptides for oral administration when formulated together with transient permeation enhancers

Berg, Staffan; Edlund, Helena; Goundry, William R. F.; Bergström, Christel et al.

Part of International Journal of Pharmaceutics, 2022

• DOI for Considerations in the developability of peptides for oral administration when formulated together with transient permeation enhancers

Gastrointestinal mucus in dog: Physiological characteristics, composition, and structural properties

Dubbelboer, Ilse R; Barmpatsalou, Vicky; Rodler, Agnes; Karlsson, Eva et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 92-102, 2022

• DOI for Gastrointestinal mucus in dog: Physiological characteristics, composition, and structural properties

Hyperthermia-Induced In Situ Drug Amorphization by Superparamagnetic Nanoparticles in Oral Dosage Forms

Ansari, Shaquib Rahman; Hempel, Nele-Johanna; Asad, Shno; Svedlindh, Peter et al.

Part of ACS Applied Materials and Interfaces, p. 21978-21988, 2022

• DOI for Hyperthermia-Induced In Situ Drug Amorphization by Superparamagnetic Nanoparticles in Oral Dosage Forms
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Impact of Intestinal Concentration and Colloidal Structure on the Permeation-Enhancing Efficiency of Sodium Caprate in the Rat

Berg, Staffan; Karrberg, Lillevi; Suljovic, Denny; Seeliger, Frank et al.

Part of Molecular Pharmaceutics, p. 200-212, 2022

• DOI for Impact of Intestinal Concentration and Colloidal Structure on the Permeation-Enhancing Efficiency of Sodium Caprate in the Rat
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Intestinal Absorption of FITC-Dextrans and Macromolecular Model Drugs in the Rat Intestinal Instillation Model

Berg, Staffan; Suljovic, Denny; Kärrberg, Lillevi; Englund, Maria et al.

Part of Molecular Pharmaceutics, p. 2564-2572, 2022

• DOI for Intestinal Absorption of FITC-Dextrans and Macromolecular Model Drugs in the Rat Intestinal Instillation Model
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Manipulations and age-appropriateness of oral medications in pediatric oncology patients in Sweden: Need for personalized dosage forms

Johannesson, Jenny; Hansson, Paula; Bergström, Christel; Paulsson, Mattias

Part of Biomedicine and Pharmacotherapy, p. 112576-112576, 2022

• DOI for Manipulations and age-appropriateness of oral medications in pediatric oncology patients in Sweden: Need for personalized dosage forms
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Membrane insertion mechanism of the caveola coat protein Cavin1

Liu, Kang-Cheng; Pace, Hudson; Larsson, Elin; Hossain, Md Shakhawath et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2022

• DOI for Membrane insertion mechanism of the caveola coat protein Cavin1
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Stabilizing Mechanisms of β-Lactoglobulin in Amorphous Solid Dispersions of Indomethacin

Kabedev, Aleksei; Zhuo, Xuezhi; Leng, Donglei; Foderà, Vito et al.

Part of Molecular Pharmaceutics, p. 3922-3933, 2022

• DOI for Stabilizing Mechanisms of β-Lactoglobulin in Amorphous Solid Dispersions of Indomethacin
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UNGAP best practice for improving solubility data quality of orally administered drugs

Vertzoni, M.; Alsenz, J.; Augustijns, P.; Bauer-Brandl, A. et al.

Part of European Journal of Pharmaceutical Sciences, 2022

• DOI for UNGAP best practice for improving solubility data quality of orally administered drugs
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3D-printing of solid lipid tablets from emulsion gels

Johannesson, Jenny; Khan, Jamal; Hubert, Madlen; Teleki, Alexandra et al.

Part of International Journal of Pharmaceutics, 2021

• DOI for 3D-printing of solid lipid tablets from emulsion gels
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A comparison of chitosan, mesoporous silica and poly(lactic-co-glycolic) acid nanocarriers for optimising intestinal uptake of oral protein therapeutics

Wright, Leah; Joyce, Paul; Barnes, Timothy J.; Lundmark, Richard et al.

Part of Journal of Pharmaceutical Sciences, p. 217-227, 2021

• DOI for A comparison of chitosan, mesoporous silica and poly(lactic-co-glycolic) acid nanocarriers for optimising intestinal uptake of oral protein therapeutics

A Tribute to Professor Per Artursson - Scientist, Explorer, Mentor, Innovator, and Giant in Pharmaceutical Research

Matsson, Pär; Baranczewski, Pawel; Giacomini, Kathleen M.; Andersson, Tommy B. et al.

Part of Journal of Pharmaceutical Sciences, p. 2-11, 2021

• DOI for A Tribute to Professor Per Artursson - Scientist, Explorer, Mentor, Innovator, and Giant in Pharmaceutical Research

Celebrating Women in the Pharmaceutical Sciences

Taylor, Lynne S.; Bergström, Christel; Lavasanifar, Afsaneh; Qian, Feng et al.

Part of Molecular Pharmaceutics, p. 1487-1490, 2021

• DOI for Celebrating Women in the Pharmaceutical Sciences

Contemporary formulation development for inhaled pharmaceuticals

Sou, Tomás; Bergström, Christel A. S.

Part of Journal of Pharmaceutical Sciences, p. 66-86, 2021

• DOI for Contemporary formulation development for inhaled pharmaceuticals
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Design and Evaluation of New Quinazolin-4(3H)-one Derived PqsR Antagonists as Quorum Sensing Quenchers in Pseudomonas aeruginosa

Soukarieh, Fadi; Mashabi, Alaa; Richardson, William; Oton, Eduard Vico et al.

Part of ACS - Infectious Diseases, p. 2666-2685, 2021

• DOI for Design and Evaluation of New Quinazolin-4(3H)-one Derived PqsR Antagonists as Quorum Sensing Quenchers in Pseudomonas aeruginosa
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Impact of Simulated Intestinal Fluids on Dissolution, Solution Chemistry, and Membrane Transport of Amorphous Multidrug Formulations

El Sayed, Mira; Alhalaweh, Amjad; Bergström, Christel

Part of Molecular Pharmaceutics, p. 4079-4089, 2021

• DOI for Impact of Simulated Intestinal Fluids on Dissolution, Solution Chemistry, and Membrane Transport of Amorphous Multidrug Formulations
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Increasing the Transport of Celecoxib over a Simulated Intestine Cell Membrane Model Using Mesoporous Magnesium Carbonate

Gómez de la Torre, Johan; Bergström, Christel; Zardán Gómez de la Torre, Teresa

Part of Molecules, 2021

• DOI for Increasing the Transport of Celecoxib over a Simulated Intestine Cell Membrane Model Using Mesoporous Magnesium Carbonate
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Investigation of Self-Emulsifying Drug-Delivery System Interaction with a Biomimetic Membrane under Conditions Relevant to the Small Intestine

Hedge, Oliver; Höök, Fredrik; Joyce, Paul; Bergström, Christel

Part of Langmuir, p. 10200-10213, 2021

• DOI for Investigation of Self-Emulsifying Drug-Delivery System Interaction with a Biomimetic Membrane under Conditions Relevant to the Small Intestine
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In Vitro and In Vivo Evaluation of 3D Printed Capsules with Pressure Triggered Release Mechanism for Oral Peptide Delivery

Berg, Staffan; Krause, Julius; Björkbom, Anders; Walter, Katrin et al.

Part of Journal of Pharmaceutical Sciences, p. 228-238, 2021

• DOI for In Vitro and In Vivo Evaluation of 3D Printed Capsules with Pressure Triggered Release Mechanism for Oral Peptide Delivery

Molecular dynamics simulations reveal membrane interactions for poorly water-soluble drugs: impact of bile solubilization and drug aggregation

Kabedev, Aleksei; Hossain, Shakhawath; Hubert, Madlen; Larsson, Per et al.

Part of Journal of Pharmaceutical Sciences, p. 176-185, 2021

• DOI for Molecular dynamics simulations reveal membrane interactions for poorly water-soluble drugs: impact of bile solubilization and drug aggregation
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Pharmaceutical Profiling and Molecular Dynamics Simulations Reveal Crystallization Effects in Amorphous Formulations

Edueng, Khadijah; Kabedev, Aleksei; Ekdahl, Alyssa; Mahlin, Denny et al.

Part of International Journal of Pharmaceutics, 2021

• DOI for Pharmaceutical Profiling and Molecular Dynamics Simulations Reveal Crystallization Effects in Amorphous Formulations

Physiological properties, composition and structural profiling of porcine gastrointestinal mucus

Barmpatsalou, Vicky; Dubbelboer, Ilse R; Rodler, Agnes; Jacobson, Magdalena et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 156-167, 2021

• DOI for Physiological properties, composition and structural profiling of porcine gastrointestinal mucus
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Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease

Asad, Shno; Wegler, Christine; Ahl, David; Bergström, Christel A. S. et al.

Part of Journal of Pharmaceutical Sciences, p. 239-250, 2021

• DOI for Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease
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Synergistic Computational Modeling Approaches as Team Players in the Game of Solubility Predictions

Kuentz, Martin; Bergström, Christel A.S.

Part of Journal of Pharmaceutical Sciences, p. 22-34, 2021

• DOI for Synergistic Computational Modeling Approaches as Team Players in the Game of Solubility Predictions

TIRF Microscopy‐Based Monitoring of Drug Permeation Across a Lipid Membrane Supported on Mesoporous Silica

Joyce, Paul; Jõemetsa, Silver; Isaksson, Simon; Hossain, Shakhawath et al.

Part of Angewandte Chemie International Edition, p. 2069-2073, 2021

• DOI for TIRF Microscopy‐Based Monitoring of Drug Permeation Across a Lipid Membrane Supported on Mesoporous Silica
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Utilizing Laser Activation of Photothermal Plasmonic Nanoparticles to Induce On-Demand Drug Amorphization inside a Tablet

Hempel, Nele-Johanna; Merkl, Padryk; Asad, Shno; Knopp, Matthias Manne et al.

Part of Molecular Pharmaceutics, p. 2254-2262, 2021

• DOI for Utilizing Laser Activation of Photothermal Plasmonic Nanoparticles to Induce On-Demand Drug Amorphization inside a Tablet