Lands grupp

Upptäckt och modifiering av redoxaktiva metallenzymer
Vår forskning
Landgruppen fokuserar på upptäckt och modifiering av redoxaktiva metallenzymer. Vår forskning är interdisciplinär och kombinerar proteinmodifiering, bio-oorganisk kemi och biofysik på enzymer som katalyserar miljörelevanta reaktioner.
Vårt labb huserar en oavbruten anaerob plattform för screening av enzymbibliotek som möjliggör riktad evolution av syrekänsliga enzymer. Detta innefattar förmågan att anaerobt utföra proteinuttryck, cellskörd och spektrofotometrisk analys.
Gruppmedlemmar
Publikationer
Ingår i Journal of the American Chemical Society, s. 4654-4666, 2025
- DOI för Probing the Influence of the Protein Scaffold on H-Cluster Reactivity via Gain-of-Function Studies─Improved H2 Evolution and O2 Tolerance through Rational Design of [FeFe] Hydrogenase
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Minimal and hybrid hydrogenases are active from archaea
Ingår i Cell, 2024
- DOI för Minimal and hybrid hydrogenases are active from archaea
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Ingår i Chemical Science, s. 16789-16795, 2024
- DOI för Photobiocatalytic CO2 reduction into CO by organic nanorod-carbon monoxide dehydrogenase assemblies: surfactant matters
- Ladda ner fulltext (pdf) av Photobiocatalytic CO2 reduction into CO by organic nanorod-carbon monoxide dehydrogenase assemblies: surfactant matters
Secondary structure changes as the potential H2 sensing mechanism of group D [FeFe]-hydrogenases
Ingår i Chemical Communications, s. 10914-10917, 2024
- DOI för Secondary structure changes as the potential H2 sensing mechanism of group D [FeFe]-hydrogenases
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Ingår i ACS Catalysis, s. 10435-10446, 2023
- DOI för Probing Substrate Transport Effects on Enzymatic Hydrogen Catalysis: An Alternative Proton Transfer Pathway in Putatively Sensory [FeFe] Hydrogenase
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Ingår i ACS Sustainable Chemistry and Engineering, s. 10760-10767, 2022
- DOI för Light-Driven [FeFe] Hydrogenase Based H-2 Production in E. coli: A Model Reaction for Exploring E. coli Based Semiartificial Photosynthetic Systems
- Ladda ner fulltext (pdf) av Light-Driven [FeFe] Hydrogenase Based H-2 Production in E. coli: A Model Reaction for Exploring E. coli Based Semiartificial Photosynthetic Systems
Ingår i Advanced Synthesis and Catalysis, s. 2972-2981, 2022
- DOI för Enantioselective Synthesis of Pharmaceutically Relevant Bulky Arylbutylamines Using Engineered Transaminases
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Reversible or Irreversible Catalysis of H+/H2 Conversion by FeFe Hydrogenases
Ingår i Journal of the American Chemical Society, s. 20320-20325, 2021
Semi-synthetic hydrogenases—in vitro and in vivo applications
Ingår i Current Opinion in Green and Sustainable Chemistry, 2021
- DOI för Semi-synthetic hydrogenases—in vitro and in vivo applications
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Ingår i Cell Reports Physical Science, 2021
- DOI för Semisynthetic [FeFe]-hydrogenase with stable expression and H2 production capacity in a photosynthetic microbe
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Ingår i ACS Catalysis, s. 9943-9952, 2020
- DOI för Carbon Dots and [FeFe] Hydrogenase Biohybrid Assemblies for Efficient Light-Driven Hydrogen Evolution
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Ingår i Advanced Synthesis and Catalysis, s. 812-821, 2020
- DOI för Engineering the Active Site of an (S)-Selective Amine Transaminase for Acceptance of Doubly Bulky Primary Amines
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Ingår i Chemical Science, s. 12789-12801, 2020
- DOI för Characterization of a putative sensory [FeFe]-hydrogenase provides new insight into the role of the active site architecture
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Current State of [FeFe]-Hydrogenase Research: Biodiversity and Spectroscopic Investigations
Ingår i ACS Catalysis, s. 7069-7086, 2020
The maturase HydF enables [FeFe] hydrogenase assembly via transient, cofactor-dependent interactions
Ingår i Journal of Biological Chemistry, s. 11891-11901, 2020
- DOI för The maturase HydF enables [FeFe] hydrogenase assembly via transient, cofactor-dependent interactions
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Ingår i ChemBioChem, s. 1297-1304, 2019
- DOI för B-factor Guided Proline Substitutions in Chromobacterium violaceum Amine Transaminase: Evaluation of the Proline Rule as a Method for Enzyme Stabilization
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Discovery of novel [FeFe]-hydrogenases for biocatalytic H-2-production
Ingår i Chemical Science, s. 9941-9948, 2019
- DOI för Discovery of novel [FeFe]-hydrogenases for biocatalytic H-2-production
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