Translationell avbildning med PET

Olof Erikssons forskargrupp använder moderna molekylära avbildningstekniker (positronemissionstomografi, PET) och radioligander för att förbättra diagnostik och behandling av livshotande och kroniska sjukdomar.
Om positronemissiontomografi (PET):
Molekylär eller medicinsk avbildning är tekniker som används inom sjukvård och forskning för att upptäcka sjukdomar på tidigt stadium, helt utan att behöva ta vävnadsbiopsier.
Forskargruppen använder nuklearmedicinska tekniker, som till exempel positronemissionstomografi (PET), som använder svagt radioaktiva ämnen, s.k. spårämnen, för att avbilda celler eller protein i kroppens organ. PET tekniken är mycket känslig, och möjliggör därför avbildning av sjukdomsprocesser som tidigare varit osynliga.
I vår forskning utvecklar vi nya spårämnen, som möjliggör tidigare diagnostik, samt att rätt behandling kan ges till rätt patienter. Detta medför att sjukdomar kan behandlas på att tidigt stadium, medan de fortfarande kan botas eller lidras.
VI är speciellt intresserad av att ta fram nya spårämnen för diagnostik och terapi av sjukdomar som förväntas öka kraftigt i framtiden, i takt med att vi blir allt äldre - som diabetes and cancer.
För mer information om vår forskning:
Publikationer
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Ingår i Nuclear Medicine and Biology, 2026
- DOI för [68Ga]Ga-NOTA-ATH001 positron emission tomography as a general tool for non-invasive detection of platelet derived growth factor receptor beta in mesenchymal cells
- Ladda ner fulltext (pdf) av [68Ga]Ga-NOTA-ATH001 positron emission tomography as a general tool for non-invasive detection of platelet derived growth factor receptor beta in mesenchymal cells
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Ingår i EJNMMI Radiopharmacy and Chemistry, 2026
- DOI för A novel 18F-labelled tetrazine ester prosthetic group for improved radiolabelling and in vivo stability of proteins and peptides
- Ladda ner fulltext (pdf) av A novel 18F-labelled tetrazine ester prosthetic group for improved radiolabelling and in vivo stability of proteins and peptides
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Ingår i Neurotherapeutics, 2026
- DOI för Brain interstitial fluid pharmacokinetics and therapeutic effect of a BBB penetrating amyloid beta antibody measured by microdialysis
- Ladda ner fulltext (pdf) av Brain interstitial fluid pharmacokinetics and therapeutic effect of a BBB penetrating amyloid beta antibody measured by microdialysis
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Ingår i Protein Engineering Design & Selection, 2026
- DOI för Combining bacterial display and protein language models to engineer a CD69-binding affibody for molecular imaging of immune activation
- Ladda ner fulltext (pdf) av Combining bacterial display and protein language models to engineer a CD69-binding affibody for molecular imaging of immune activation
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Ingår i Cell Stem Cell, s. 1324-1338, 2026
- DOI för Extracellular vesicle secretome from mesenchymal stromal cells prevents post-ischemic heart failure by targeting cardiac fibrosis
- Ladda ner fulltext (pdf) av Extracellular vesicle secretome from mesenchymal stromal cells prevents post-ischemic heart failure by targeting cardiac fibrosis
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Ingår i Diabetes, obesity and metabolism, s. 4876-4883, 2026
- DOI för In vivo imaging of the innate immune system in the pancreas in new-onset and long-standing type 1 diabetes
- Ladda ner fulltext (pdf) av In vivo imaging of the innate immune system in the pancreas in new-onset and long-standing type 1 diabetes
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Increased affinity by dimerization of radiolabeled Affibody molecule ATH001 targeting PDGFRβ
Ingår i EJNMMI Radiopharmacy and Chemistry, 2026
- DOI för Increased affinity by dimerization of radiolabeled Affibody molecule ATH001 targeting PDGFRβ
- Ladda ner fulltext (pdf) av Increased affinity by dimerization of radiolabeled Affibody molecule ATH001 targeting PDGFRβ
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Novel approaches for PET imaging of endometriosis
Ingår i Nuclear Medicine and Biology, 2026
- DOI för Novel approaches for PET imaging of endometriosis
- Ladda ner fulltext (pdf) av Novel approaches for PET imaging of endometriosis
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Positron Emission Tomography imaging of tumor necrosis factor in lung injury
Ingår i Upsala Journal of Medical Sciences, 2026
- DOI för Positron Emission Tomography imaging of tumor necrosis factor in lung injury
- Ladda ner fulltext (pdf) av Positron Emission Tomography imaging of tumor necrosis factor in lung injury
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DGCR2 targeting affibody molecules for delivery of drugs and imaging reagents to human beta cells
Ingår i Scientific Reports, 2025
- DOI för DGCR2 targeting affibody molecules for delivery of drugs and imaging reagents to human beta cells
- Ladda ner fulltext (pdf) av DGCR2 targeting affibody molecules for delivery of drugs and imaging reagents to human beta cells
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Ingår i EJNMMI Radiopharmacy and Chemistry, 2025
- DOI för Extending the shelf life of 68Ge/68Ga generators via preconcentration of [68Ga]GaCl3 for preclinical application
- Ladda ner fulltext (pdf) av Extending the shelf life of 68Ge/68Ga generators via preconcentration of [68Ga]GaCl3 for preclinical application
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Ingår i Pharmaceuticals, 2025
- DOI för Ga-68-Labeled Affibody Molecule-Based Radiopharmaceutical Targeting Platelet Derived Growth Factor Receptor Beta for Detection of Active Fibrosis in Patients with Myocardial Infarction
- Ladda ner fulltext (pdf) av Ga-68-Labeled Affibody Molecule-Based Radiopharmaceutical Targeting Platelet Derived Growth Factor Receptor Beta for Detection of Active Fibrosis in Patients with Myocardial Infarction
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Ingår i EJNMMI Radiopharmacy and Chemistry, 2025
- DOI för PDGFRβ targeted positron emission tomography as a non-invasive biomarker for activated hepatic stellate cells: lasts steps before clinical translation
- Ladda ner fulltext (pdf) av PDGFRβ targeted positron emission tomography as a non-invasive biomarker for activated hepatic stellate cells: lasts steps before clinical translation
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PET imaging of platelet derived growth factor receptor β in lung fibrosis
Ingår i EJNMMI Radiopharmacy and Chemistry, 2025
- DOI för PET imaging of platelet derived growth factor receptor β in lung fibrosis
- Ladda ner fulltext (pdf) av PET imaging of platelet derived growth factor receptor β in lung fibrosis
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Ingår i Intensive Care Medicine Experimental, 2025
- DOI för Repeated positron emission tomography tracing neutrophil elastase in a porcine intensive-care sepsis model
- Ladda ner fulltext (pdf) av Repeated positron emission tomography tracing neutrophil elastase in a porcine intensive-care sepsis model
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Ingår i EJNMMI Radiopharmacy and Chemistry, 2025
- DOI för Selection of the optimal chelator for labeling of DARPin Ec1 with gallium-68 for PET imaging of EpCAM expression
- Ladda ner fulltext (pdf) av Selection of the optimal chelator for labeling of DARPin Ec1 with gallium-68 for PET imaging of EpCAM expression
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Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression
Ingår i New England Journal of Medicine, s. 887-894, 2025
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Ingår i EJNMMI Radiopharmacy and Chemistry, 2025
- DOI för Synthesis and preclinical evaluation of gastrin releasing peptide receptor antagonist [18F]MeTz-PEG2-RM26 for positron emission tomography
- Ladda ner fulltext (pdf) av Synthesis and preclinical evaluation of gastrin releasing peptide receptor antagonist [18F]MeTz-PEG2-RM26 for positron emission tomography
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Ingår i Journal of Clinical Oncology, 2024
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Ingår i ACS Pharmacology & Translational Science, s. 3228-3240, 2024
- DOI för Affibody-Drug Conjugates Targeting the Human Epidermal Growth Factor Receptor-3 Demonstrate Therapeutic Efficacy in Mice Bearing Low Expressing Xenografts
- Ladda ner fulltext (pdf) av Affibody-Drug Conjugates Targeting the Human Epidermal Growth Factor Receptor-3 Demonstrate Therapeutic Efficacy in Mice Bearing Low Expressing Xenografts
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Evaluation of ABD-Linked RM26 Conjugates for GRPR-Targeted Drug Delivery
Ingår i ACS Omega, s. 36122-36133, 2024
- DOI för Evaluation of ABD-Linked RM26 Conjugates for GRPR-Targeted Drug Delivery
- Ladda ner fulltext (pdf) av Evaluation of ABD-Linked RM26 Conjugates for GRPR-Targeted Drug Delivery
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Ingår i Pharmaceutics, 2024
- DOI för GRPR-Antagonists Carrying DOTAGA-Chelator via Positively Charged Linkers: Perspectives for Prostate Cancer Theranostics
- Ladda ner fulltext (pdf) av GRPR-Antagonists Carrying DOTAGA-Chelator via Positively Charged Linkers: Perspectives for Prostate Cancer Theranostics
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Ingår i Journal of Controlled Release, s. 468-478, 2024
- DOI för Half-life extension via ABD-fusion leads to higher tumor uptake of an affibody-drug conjugate compared to PAS- and XTENylation.
- Ladda ner fulltext (pdf) av Half-life extension via ABD-fusion leads to higher tumor uptake of an affibody-drug conjugate compared to PAS- and XTENylation.
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Improved Localization of Insulinomas Using 68Ga-NODAGA-Exendin-4 PET/CT
Ingår i Journal of Nuclear Medicine, s. 1959-1964, 2024
- DOI för Improved Localization of Insulinomas Using 68Ga-NODAGA-Exendin-4 PET/CT
- Ladda ner fulltext (pdf) av Improved Localization of Insulinomas Using 68Ga-NODAGA-Exendin-4 PET/CT
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Ingår i Nuclear Medicine and Biology, 2024
- DOI för Introduction of a fatty acid chain modification to prolong circulatory half-life of a radioligand towards glucose-dependent insulinotropic polypeptide receptor
- Ladda ner fulltext (pdf) av Introduction of a fatty acid chain modification to prolong circulatory half-life of a radioligand towards glucose-dependent insulinotropic polypeptide receptor
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Non-invasive imaging of sympathetic innervation of the pancreas in individuals with type 2 diabetes
Ingår i Diabetologia, s. 199-208, 2024
- DOI för Non-invasive imaging of sympathetic innervation of the pancreas in individuals with type 2 diabetes
- Ladda ner fulltext (pdf) av Non-invasive imaging of sympathetic innervation of the pancreas in individuals with type 2 diabetes
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Ingår i Journal of Nuclear Medicine, s. 294-299, 2024
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Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule
Ingår i iScience, 2024
- DOI för Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule
- Ladda ner fulltext (pdf) av Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule
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Optimized method for fluorine-18 radiolabeling of Affibody molecules using RESCA
Ingår i EJNMMI Radiopharmacy and Chemistry, 2024
- DOI för Optimized method for fluorine-18 radiolabeling of Affibody molecules using RESCA
- Ladda ner fulltext (pdf) av Optimized method for fluorine-18 radiolabeling of Affibody molecules using RESCA
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PET imaging of GABAA receptors in pancreatic islets by [11C]flumazenil
Ingår i EJNMMI Research, 2024
- DOI för PET imaging of GABAA receptors in pancreatic islets by [11C]flumazenil
- Ladda ner fulltext (pdf) av PET imaging of GABAA receptors in pancreatic islets by [11C]flumazenil
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PET imaging of inflammation and fibrosis
2024
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Ingår i Intensive Care Medicine Experimental, 2024
- DOI för Regional distribution of mechanical strain and macrophage-associated lung inflammation after ventilator-induced lung injury: an experimental study
- Ladda ner fulltext (pdf) av Regional distribution of mechanical strain and macrophage-associated lung inflammation after ventilator-induced lung injury: an experimental study
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Ingår i ACS Omega, s. 18608-18616, 2024
- DOI för Two Novel [68Ga]Ga-Labeled Radiotracers Based on Metabolically Stable [Sar11]RM26 Antagonistic Peptide for Diagnostic Positron Emission Tomography Imaging of GRPR-Positive Prostate Cancer
- Ladda ner fulltext (pdf) av Two Novel [68Ga]Ga-Labeled Radiotracers Based on Metabolically Stable [Sar11]RM26 Antagonistic Peptide for Diagnostic Positron Emission Tomography Imaging of GRPR-Positive Prostate Cancer
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[18F]MK-7246 for Positron Emission Tomography Imaging of the Beta-Cell Surface Marker GPR44
Ingår i Pharmaceutics, 2023
- DOI för [18F]MK-7246 for Positron Emission Tomography Imaging of the Beta-Cell Surface Marker GPR44
- Ladda ner fulltext (pdf) av [18F]MK-7246 for Positron Emission Tomography Imaging of the Beta-Cell Surface Marker GPR44
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Ingår i Biomedical Materials, 2023
- DOI för Bone formation beyond the skeletal envelope using calcium phosphate granules packed into a collagen pouch-a pilot study
- Ladda ner fulltext (pdf) av Bone formation beyond the skeletal envelope using calcium phosphate granules packed into a collagen pouch-a pilot study
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Ingår i Biomaterials Science, s. 3144-3158, 2023
- DOI för Fe and C additions decrease the dissolution rate of silicon nitride coatings and are compatible with microglial viability in 3D collagen hydrogels
- Ladda ner fulltext (pdf) av Fe and C additions decrease the dissolution rate of silicon nitride coatings and are compatible with microglial viability in 3D collagen hydrogels
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Ingår i Journal of Nuclear Medicine, s. 1364-1370, 2023
- DOI för Human Epidermal Growth Factor Receptor 2-Targeting [68Ga]Ga-ABY-025 PET/CT Predicts Early Metabolic Response in Metastatic Breast Cancer.
- Ladda ner fulltext (pdf) av Human Epidermal Growth Factor Receptor 2-Targeting [68Ga]Ga-ABY-025 PET/CT Predicts Early Metabolic Response in Metastatic Breast Cancer.
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Ingår i Journal of Functional Biomaterials, 2023
- DOI för Human Whole Blood Interactions with Craniomaxillofacial Reconstruction Materials: Exploring In Vitro the Role of Blood Cascades and Leukocytes in Early Healing Events
- Ladda ner fulltext (pdf) av Human Whole Blood Interactions with Craniomaxillofacial Reconstruction Materials: Exploring In Vitro the Role of Blood Cascades and Leukocytes in Early Healing Events
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Ingår i Pharmaceuticals, 2023
- DOI för Imaging of the Glucose-Dependent Insulinotropic Polypeptide Receptor Using a Novel Radiolabeled Peptide Rationally Designed Based on Endogenous GIP and Synthetic Exendin-4 Sequences
- Ladda ner fulltext (pdf) av Imaging of the Glucose-Dependent Insulinotropic Polypeptide Receptor Using a Novel Radiolabeled Peptide Rationally Designed Based on Endogenous GIP and Synthetic Exendin-4 Sequences
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In Vivo Imaging of the Pancreas and Gut Hormone Receptors
Ingår i Nanotechnology for Diabetes Management, s. 262-291, Royal Society of Chemistry, 2023
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Ingår i Journal of Nuclear Medicine, s. 145-148, 2023
- DOI för In Vivo Visualization and Quantification of Neutrophil Elastase in Lungs of COVID-19 Patients: A First-in-Humans PET Study with 11C-NES
- Ladda ner fulltext (pdf) av In Vivo Visualization and Quantification of Neutrophil Elastase in Lungs of COVID-19 Patients: A First-in-Humans PET Study with 11C-NES
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Nanostructured Ag-Bioglass Implant Coatings with Antibacterial and Osteogenic Activity
Ingår i Advanced Materials Interfaces, 2023
- DOI för Nanostructured Ag-Bioglass Implant Coatings with Antibacterial and Osteogenic Activity
- Ladda ner fulltext (pdf) av Nanostructured Ag-Bioglass Implant Coatings with Antibacterial and Osteogenic Activity
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PET imaging of neutrophil elastase with 11C-GW457427 in Acute Respiratory Distress Syndrome in pigs
Ingår i Journal of Nuclear Medicine, s. 423-429, 2023
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Ingår i EJNMMI Research, s. 107, 2023
- DOI för Preclinical evaluation of Affibody molecule for PET imaging of human pancreatic islets derived from stem cells.
- Ladda ner fulltext (pdf) av Preclinical evaluation of Affibody molecule for PET imaging of human pancreatic islets derived from stem cells.
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Radiotracers for Imaging of Fibrosis: Advances during the Last Two Decades and Future Directions
Ingår i Pharmaceuticals, 2023
- DOI för Radiotracers for Imaging of Fibrosis: Advances during the Last Two Decades and Future Directions
- Ladda ner fulltext (pdf) av Radiotracers for Imaging of Fibrosis: Advances during the Last Two Decades and Future Directions
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2023
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Translational PET imaging of inflammation
2023
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Ingår i Cell Metabolism, s. 59-+, 2022
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Glucagonlike Peptide-1 Receptor Imaging in Individuals with Type 2 Diabetes
Ingår i Journal of Nuclear Medicine, s. 794-800, 2022
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Guiding bone formation using semi‐onlay calcium phosphate implants in an ovine calvarial model
Ingår i Journal of Tissue Engineering and Regenerative Medicine, s. 435-447, 2022
- DOI för Guiding bone formation using semi‐onlay calcium phosphate implants in an ovine calvarial model
- Ladda ner fulltext (pdf) av Guiding bone formation using semi‐onlay calcium phosphate implants in an ovine calvarial model
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Aktuella publikationer
- Extracellular vesicle secretome from mesenchymal stromal cells prevents post-ischemic heart failure by targeting cardiac fibrosisGrinnemo, Karl-Henrik; Braesch-Andersen, Ken; Wedin, Johan et al., 2026
- Brain interstitial fluid pharmacokinetics and therapeutic effect of a BBB penetrating amyloid beta antibody measured by microdialysisWik, Elin; Dahlén, Amelia; Julku, Ulrika et al., 2026
- Positron Emission Tomography imaging of tumor necrosis factor in lung injuryWegrzyniak, Olivia; Han, Huayi; Eriksson, Olof, 2026