Translationell avbildning med PET

Olof Erikssons forskargrupp använder moderna molekylära avbildningstekniker (positronemissionstomografi, PET) och radioligander för att förbättra diagnostik och behandling av livshotande och kroniska sjukdomar.
Om positronemissiontomografi (PET):
Molekylär eller medicinsk avbildning är tekniker som används inom sjukvård och forskning för att upptäcka sjukdomar på tidigt stadium, helt utan att behöva ta vävnadsbiopsier.
Forskargruppen använder nuklearmedicinska tekniker, som till exempel positronemissionstomografi (PET), som använder svagt radioaktiva ämnen, s.k. spårämnen, för att avbilda celler eller protein i kroppens organ. PET tekniken är mycket känslig, och möjliggör därför avbildning av sjukdomsprocesser som tidigare varit osynliga.
I vår forskning utvecklar vi nya spårämnen, som möjliggör tidigare diagnostik, samt att rätt behandling kan ges till rätt patienter. Detta medför att sjukdomar kan behandlas på att tidigt stadium, medan de fortfarande kan botas eller lidras.
VI är speciellt intresserad av att ta fram nya spårämnen för diagnostik och terapi av sjukdomar som förväntas öka kraftigt i framtiden, i takt med att vi blir allt äldre - som diabetes and cancer.
För mer information om vår forskning:
Publikationer
DGCR2 targeting affibody molecules for delivery of drugs and imaging reagents to human beta cells
Ingår i Scientific Reports, 2025
- DOI för DGCR2 targeting affibody molecules for delivery of drugs and imaging reagents to human beta cells
- Ladda ner fulltext (pdf) av DGCR2 targeting affibody molecules for delivery of drugs and imaging reagents to human beta cells
Ingår i Intensive Care Medicine Experimental, 2025
- DOI för Repeated positron emission tomography tracing neutrophil elastase in a porcine intensive-care sepsis model
- Ladda ner fulltext (pdf) av Repeated positron emission tomography tracing neutrophil elastase in a porcine intensive-care sepsis model
Ingår i EJNMMI Radiopharmacy and Chemistry, 2025
- DOI för Selection of the optimal chelator for labeling of DARPin Ec1 with gallium-68 for PET imaging of EpCAM expression
- Ladda ner fulltext (pdf) av Selection of the optimal chelator for labeling of DARPin Ec1 with gallium-68 for PET imaging of EpCAM expression
Ingår i EJNMMI Radiopharmacy and Chemistry, 2025
- DOI för Synthesis and preclinical evaluation of gastrin releasing peptide receptor antagonist [18F]MeTz-PEG2-RM26 for positron emission tomography
- Ladda ner fulltext (pdf) av Synthesis and preclinical evaluation of gastrin releasing peptide receptor antagonist [18F]MeTz-PEG2-RM26 for positron emission tomography
Ingår i ACS Pharmacology & Translational Science, s. 3228-3240, 2024
- DOI för Affibody-Drug Conjugates Targeting the Human Epidermal Growth Factor Receptor-3 Demonstrate Therapeutic Efficacy in Mice Bearing Low Expressing Xenografts
- Ladda ner fulltext (pdf) av Affibody-Drug Conjugates Targeting the Human Epidermal Growth Factor Receptor-3 Demonstrate Therapeutic Efficacy in Mice Bearing Low Expressing Xenografts
Evaluation of ABD-Linked RM26 Conjugates for GRPR-Targeted Drug Delivery
Ingår i ACS Omega, s. 36122-36133, 2024
- DOI för Evaluation of ABD-Linked RM26 Conjugates for GRPR-Targeted Drug Delivery
- Ladda ner fulltext (pdf) av Evaluation of ABD-Linked RM26 Conjugates for GRPR-Targeted Drug Delivery
Ingår i Pharmaceutics, 2024
- DOI för GRPR-Antagonists Carrying DOTAGA-Chelator via Positively Charged Linkers: Perspectives for Prostate Cancer Theranostics
- Ladda ner fulltext (pdf) av GRPR-Antagonists Carrying DOTAGA-Chelator via Positively Charged Linkers: Perspectives for Prostate Cancer Theranostics
Ingår i Journal of Controlled Release, s. 468-478, 2024
- DOI för Half-life extension via ABD-fusion leads to higher tumor uptake of an affibody-drug conjugate compared to PAS- and XTENylation.
- Ladda ner fulltext (pdf) av Half-life extension via ABD-fusion leads to higher tumor uptake of an affibody-drug conjugate compared to PAS- and XTENylation.
Improved Localization of Insulinomas Using 68Ga-NODAGA-Exendin-4 PET/CT
Ingår i Journal of Nuclear Medicine, s. 1959-1964, 2024
- DOI för Improved Localization of Insulinomas Using 68Ga-NODAGA-Exendin-4 PET/CT
- Ladda ner fulltext (pdf) av Improved Localization of Insulinomas Using 68Ga-NODAGA-Exendin-4 PET/CT
Ingår i Nuclear Medicine and Biology, 2024
- DOI för Introduction of a fatty acid chain modification to prolong circulatory half-life of a radioligand towards glucose-dependent insulinotropic polypeptide receptor
- Ladda ner fulltext (pdf) av Introduction of a fatty acid chain modification to prolong circulatory half-life of a radioligand towards glucose-dependent insulinotropic polypeptide receptor
Non-invasive imaging of sympathetic innervation of the pancreas in individuals with type 2 diabetes
Ingår i Diabetologia, s. 199-208, 2024
- DOI för Non-invasive imaging of sympathetic innervation of the pancreas in individuals with type 2 diabetes
- Ladda ner fulltext (pdf) av Non-invasive imaging of sympathetic innervation of the pancreas in individuals with type 2 diabetes
Ingår i Journal of Nuclear Medicine, s. 294-299, 2024
Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule
Ingår i iScience, 2024
- DOI för Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule
- Ladda ner fulltext (pdf) av Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule
Optimized method for fluorine-18 radiolabeling of Affibody molecules using RESCA
Ingår i EJNMMI Radiopharmacy and Chemistry, 2024
- DOI för Optimized method for fluorine-18 radiolabeling of Affibody molecules using RESCA
- Ladda ner fulltext (pdf) av Optimized method for fluorine-18 radiolabeling of Affibody molecules using RESCA
PET imaging of GABAA receptors in pancreatic islets by [11C]flumazenil
Ingår i EJNMMI Research, 2024
- DOI för PET imaging of GABAA receptors in pancreatic islets by [11C]flumazenil
- Ladda ner fulltext (pdf) av PET imaging of GABAA receptors in pancreatic islets by [11C]flumazenil
PET imaging of inflammation and fibrosis
2024
Ingår i Intensive Care Medicine Experimental, 2024
- DOI för Regional distribution of mechanical strain and macrophage-associated lung inflammation after ventilator-induced lung injury: an experimental study
- Ladda ner fulltext (pdf) av Regional distribution of mechanical strain and macrophage-associated lung inflammation after ventilator-induced lung injury: an experimental study
Ingår i ACS Omega, s. 18608-18616, 2024
- DOI för Two Novel [68Ga]Ga-Labeled Radiotracers Based on Metabolically Stable [Sar11]RM26 Antagonistic Peptide for Diagnostic Positron Emission Tomography Imaging of GRPR-Positive Prostate Cancer
- Ladda ner fulltext (pdf) av Two Novel [68Ga]Ga-Labeled Radiotracers Based on Metabolically Stable [Sar11]RM26 Antagonistic Peptide for Diagnostic Positron Emission Tomography Imaging of GRPR-Positive Prostate Cancer
[18F]MK-7246 for Positron Emission Tomography Imaging of the Beta-Cell Surface Marker GPR44
Ingår i Pharmaceutics, 2023
- DOI för [18F]MK-7246 for Positron Emission Tomography Imaging of the Beta-Cell Surface Marker GPR44
- Ladda ner fulltext (pdf) av [18F]MK-7246 for Positron Emission Tomography Imaging of the Beta-Cell Surface Marker GPR44
Ingår i Biomedical Materials, 2023
- DOI för Bone formation beyond the skeletal envelope using calcium phosphate granules packed into a collagen pouch-a pilot study
- Ladda ner fulltext (pdf) av Bone formation beyond the skeletal envelope using calcium phosphate granules packed into a collagen pouch-a pilot study
Ingår i Biomaterials Science, s. 3144-3158, 2023
- DOI för Fe and C additions decrease the dissolution rate of silicon nitride coatings and are compatible with microglial viability in 3D collagen hydrogels
- Ladda ner fulltext (pdf) av Fe and C additions decrease the dissolution rate of silicon nitride coatings and are compatible with microglial viability in 3D collagen hydrogels
Ingår i Journal of Nuclear Medicine, s. 1364-1370, 2023
- DOI för Human Epidermal Growth Factor Receptor 2-Targeting [68Ga]Ga-ABY-025 PET/CT Predicts Early Metabolic Response in Metastatic Breast Cancer.
- Ladda ner fulltext (pdf) av Human Epidermal Growth Factor Receptor 2-Targeting [68Ga]Ga-ABY-025 PET/CT Predicts Early Metabolic Response in Metastatic Breast Cancer.
Ingår i Journal of Functional Biomaterials, 2023
- DOI för Human Whole Blood Interactions with Craniomaxillofacial Reconstruction Materials: Exploring In Vitro the Role of Blood Cascades and Leukocytes in Early Healing Events
- Ladda ner fulltext (pdf) av Human Whole Blood Interactions with Craniomaxillofacial Reconstruction Materials: Exploring In Vitro the Role of Blood Cascades and Leukocytes in Early Healing Events
Ingår i Pharmaceuticals, 2023
- DOI för Imaging of the Glucose-Dependent Insulinotropic Polypeptide Receptor Using a Novel Radiolabeled Peptide Rationally Designed Based on Endogenous GIP and Synthetic Exendin-4 Sequences
- Ladda ner fulltext (pdf) av Imaging of the Glucose-Dependent Insulinotropic Polypeptide Receptor Using a Novel Radiolabeled Peptide Rationally Designed Based on Endogenous GIP and Synthetic Exendin-4 Sequences
Ingår i Journal of Nuclear Medicine, s. 145-148, 2023
- DOI för In Vivo Visualization and Quantification of Neutrophil Elastase in Lungs of COVID-19 Patients: A First-in-Humans PET Study with 11C-NES
- Ladda ner fulltext (pdf) av In Vivo Visualization and Quantification of Neutrophil Elastase in Lungs of COVID-19 Patients: A First-in-Humans PET Study with 11C-NES
Nanostructured Ag-Bioglass Implant Coatings with Antibacterial and Osteogenic Activity
Ingår i Advanced Materials Interfaces, 2023
- DOI för Nanostructured Ag-Bioglass Implant Coatings with Antibacterial and Osteogenic Activity
- Ladda ner fulltext (pdf) av Nanostructured Ag-Bioglass Implant Coatings with Antibacterial and Osteogenic Activity
PET imaging of neutrophil elastase with 11C-GW457427 in Acute Respiratory Distress Syndrome in pigs
Ingår i Journal of Nuclear Medicine, s. 423-429, 2023
Ingår i EJNMMI Research, s. 107, 2023
- DOI för Preclinical evaluation of Affibody molecule for PET imaging of human pancreatic islets derived from stem cells.
- Ladda ner fulltext (pdf) av Preclinical evaluation of Affibody molecule for PET imaging of human pancreatic islets derived from stem cells.
Radiotracers for Imaging of Fibrosis: Advances during the Last Two Decades and Future Directions
Ingår i Pharmaceuticals, 2023
- DOI för Radiotracers for Imaging of Fibrosis: Advances during the Last Two Decades and Future Directions
- Ladda ner fulltext (pdf) av Radiotracers for Imaging of Fibrosis: Advances during the Last Two Decades and Future Directions
2023
Translational PET imaging of inflammation
2023
Ingår i Cell Metabolism, s. 59-+, 2022
Glucagonlike Peptide-1 Receptor Imaging in Individuals with Type 2 Diabetes
Ingår i Journal of Nuclear Medicine, s. 794-800, 2022
Guiding bone formation using semi‐onlay calcium phosphate implants in an ovine calvarial model
Ingår i Journal of Tissue Engineering and Regenerative Medicine, s. 435-447, 2022
- DOI för Guiding bone formation using semi‐onlay calcium phosphate implants in an ovine calvarial model
- Ladda ner fulltext (pdf) av Guiding bone formation using semi‐onlay calcium phosphate implants in an ovine calvarial model
PET-CT imaging of pulmonary inflammation using [Ga-68]Ga-DOTA-TATE
Ingår i EJNMMI Research, 2022
- DOI för PET-CT imaging of pulmonary inflammation using [Ga-68]Ga-DOTA-TATE
- Ladda ner fulltext (pdf) av PET-CT imaging of pulmonary inflammation using [Ga-68]Ga-DOTA-TATE
Ingår i Biomaterials Science, s. 3757-3769, 2022
- DOI för Tailoring the dissolution rate and in vitro cell response of silicon nitride coatings through combinatorial sputtering with chromium and niobium
- Ladda ner fulltext (pdf) av Tailoring the dissolution rate and in vitro cell response of silicon nitride coatings through combinatorial sputtering with chromium and niobium
Discovery, optimization and biodistribution of an Affibody molecule for imaging of CD69
Ingår i Scientific Reports, 2021
- DOI för Discovery, optimization and biodistribution of an Affibody molecule for imaging of CD69
- Ladda ner fulltext (pdf) av Discovery, optimization and biodistribution of an Affibody molecule for imaging of CD69
Dissolution and biocompatibility of combinatorially sputtered SiCrNbN coatings
2021
Ingår i Diabetes, s. 842-853, 2021
Ingår i BMJ Open Diabetes Research & Care, 2021
- DOI för Exploring the GLP-1-GLP-1R axis in porcine pancreas and gastrointestinal tract in vivo by ex vivo autoradiography
- Ladda ner fulltext (pdf) av Exploring the GLP-1-GLP-1R axis in porcine pancreas and gastrointestinal tract in vivo by ex vivo autoradiography
Improved Radiolytic Stability of a 68Ga-labelled Collagelin Analogue for the Imaging of Fibrosis
Ingår i Pharmaceuticals, 2021
- DOI för Improved Radiolytic Stability of a 68Ga-labelled Collagelin Analogue for the Imaging of Fibrosis
- Ladda ner fulltext (pdf) av Improved Radiolytic Stability of a 68Ga-labelled Collagelin Analogue for the Imaging of Fibrosis
Longitudinal Assessment of 11C-5-Hydroxytryptophan Uptake in Pancreas After Debut of Type 1 Diabetes
Ingår i Diabetes, s. 966-975, 2021
News ways of understanding the complex biology of diabetes using PET
Ingår i Nuclear Medicine and Biology, s. 65-71, 2021
PET Imaging of GPR44 by Antagonist [C-11]MK-7246 in Pigs
Ingår i Biomedicines, 2021
- DOI för PET Imaging of GPR44 by Antagonist [C-11]MK-7246 in Pigs
- Ladda ner fulltext (pdf) av PET Imaging of GPR44 by Antagonist [C-11]MK-7246 in Pigs
Potential of [C-11]UCB-J as a PET tracer for islets of Langerhans
Ingår i Scientific Reports, 2021
- DOI för Potential of [C-11]UCB-J as a PET tracer for islets of Langerhans
- Ladda ner fulltext (pdf) av Potential of [C-11]UCB-J as a PET tracer for islets of Langerhans
Ingår i Nuclear Medicine and Biology, s. 54-62, 2021
- DOI för Radiolabelling and positron emission tomography imaging of a high-affinity peptide binder to collagen type 1
- Ladda ner fulltext (pdf) av Radiolabelling and positron emission tomography imaging of a high-affinity peptide binder to collagen type 1
Recent Progress in the Molecular Imaging of Nonalcoholic Fatty Liver Disease
Ingår i International Journal of Molecular Sciences, 2021
- DOI för Recent Progress in the Molecular Imaging of Nonalcoholic Fatty Liver Disease
- Ladda ner fulltext (pdf) av Recent Progress in the Molecular Imaging of Nonalcoholic Fatty Liver Disease
Ingår i ACS Applied Bio Materials, s. 6791-6798, 2021
- DOI för Targeted ToF-SIMS Analysis of Macrophage Content from a Human Cranial Triphasic Calcium Phosphate Implant
- Ladda ner fulltext (pdf) av Targeted ToF-SIMS Analysis of Macrophage Content from a Human Cranial Triphasic Calcium Phosphate Implant
The Current State of Beta-Cell-Mass PET Imaging for Diabetes Research and Therapies
Ingår i Biomedicines, 2021
- DOI för The Current State of Beta-Cell-Mass PET Imaging for Diabetes Research and Therapies
- Ladda ner fulltext (pdf) av The Current State of Beta-Cell-Mass PET Imaging for Diabetes Research and Therapies
Theranostic Approach in Breast Cancer A Treasured Tailor for Future Oncology
Ingår i Clinical Nuclear Medicine, 2021
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