MUSIC investigates how cancer cells adapt to their surroundings, using glioblastoma, an aggressive brain tumour, as a model. The project leverages microfluidic engineering, cancer biology, immunology and artificial intelligence and the research team will develop human tumour-on-chip models incorporating blood vessels and immune cells to study how tissue structure, mechanical properties and chemical signals influence cancer cell behaviour. Advanced imaging and molecular analysis will reveal how individual cells change over time, while computational modelling will help identify the mechanisms driving these changes. It is our ambition that findings will advance our understanding of cancer invasion and inform future therapeutic research.