Characterization of Freshly Isolated Human Peripheral Blood B Cells, Monocytes, CD4⁺ and CD8⁺ T Cells, and Skin Mast Cells by Quantitative Transcriptomics

Akula, Srinivas; Alvarado-Vazquez, Abigail; Mendez Enriquez, Erika Haide; Bal, Gürkan et al.

Ingår i International Journal of Molecular Sciences, 2024

• DOI för Characterization of Freshly Isolated Human Peripheral Blood B Cells, Monocytes, CD4⁺ and CD8⁺ T Cells, and Skin Mast Cells by Quantitative Transcriptomics
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Cultures of Human Skin Mast Cells, an Attractive In Vitro Model for Studies of Human Mast Cell Biology

Akula, Srinivas; Tripathi, Shiva Raj; Franke, Kristin; Wernersson, Sara et al.

Ingår i Cells, 2024

• DOI för Cultures of Human Skin Mast Cells, an Attractive In Vitro Model for Studies of Human Mast Cell Biology
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Extended Cleavage Specificity of two Hematopoietic Serine Proteases from a Ray-Finned Fish, the Spotted Gar (Lepisosteus oculatus)

Valentini, Paolo; Akula, Srinivas; Alvarado-Vazquez, Perla Abigail; Hallgren, Jenny et al.

Ingår i International Journal of Molecular Sciences, 2024

• DOI för Extended Cleavage Specificity of two Hematopoietic Serine Proteases from a Ray-Finned Fish, the Spotted Gar (Lepisosteus oculatus)
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Mast Cells are Dependent on Glucose Transporter 1 (GLUT1) and GLUT3 for IgE-mediated Activation

Grujic, Mirjana; Alim, Md Abdul; Hellman, Lars; Peterson, Magnus et al.

Ingår i Inflammation, s. 1820-1836, 2024

• DOI för Mast Cells are Dependent on Glucose Transporter 1 (GLUT1) and GLUT3 for IgE-mediated Activation
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The Extended Cleavage Specificity of Channel Catfish Granzyme-like II, A Highly Specific Elastase, Expressed by Natural Killer-like Cells

Thorpe, Michael; Akula, Srinivas; Fu, Zhirong; Hellman, Lars

Ingår i International Journal of Molecular Sciences, 2024

• DOI för The Extended Cleavage Specificity of Channel Catfish Granzyme-like II, A Highly Specific Elastase, Expressed by Natural Killer-like Cells
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Extended cleavage specificities of human granzymes A and K, two closely related enzymes with conserved but still poorly defined functions in T and NK cell-mediated immunity

Aybay, Erdem; Ryu, Jinhye; Fu, Zhirong; Akula, Srinivas et al.

Ingår i Frontiers in Immunology, 2023

• DOI för Extended cleavage specificities of human granzymes A and K, two closely related enzymes with conserved but still poorly defined functions in T and NK cell-mediated immunity
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House Dust Mite and Cat Dander Extract Induce Asthma-Like Histopathology with an Increase of Mucosal Mast Cells in a Guinea Pig Model

Ramos-Ramirez, Patricia; Liu, Jielu; Mogren, Sofia; Gregory, Joshua et al.

Ingår i Journal of Immunology Research, 2023

• DOI för House Dust Mite and Cat Dander Extract Induce Asthma-Like Histopathology with an Increase of Mucosal Mast Cells in a Guinea Pig Model
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Identification of the Major Protein Components of Human and Cow Saliva

Akula, Srinivas; Welinder, Charlotte; Fu, Zhirong; Olsson, Anna-Karin et al.

Ingår i International Journal of Molecular Sciences, 2023

• DOI för Identification of the Major Protein Components of Human and Cow Saliva
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Phenotypic and Functional Heterogeneity of Monocytes and Macrophages

Hellman, Lars

Ingår i International Journal of Molecular Sciences, 2023

• DOI för Phenotypic and Functional Heterogeneity of Monocytes and Macrophages
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Single-cell transcriptomics delineates the immune cell landscape in equine lower airways and reveals upregulation of FKBP5 in horses with asthma.

Riihimäki, Miia; Fegraeus, K. Jaderkvist; Nordlund, Jessica; Waern, Ida et al.

Ingår i Scientific Reports, s. 16261, 2023

• DOI för Single-cell transcriptomics delineates the immune cell landscape in equine lower airways and reveals upregulation of FKBP5 in horses with asthma.
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Two granzyme A/K homologs in Zebra mbuna have different specificities, one classical tryptase and one with chymase activity

Aybay, Erdem; Elkhalifa, Mamoun; Akula, Srinivas; Wernersson, Sara et al.

Ingår i Developmental and Comparative Immunology, 2023

• DOI för Two granzyme A/K homologs in Zebra mbuna have different specificities, one classical tryptase and one with chymase activity
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Analysis of the mast cell expressed carboxypeptidase A3 and its structural and evolutionary relationship to other vertebrate carboxypeptidases

Akula, Srinivas; Hellman, Lars; Aviles, Francesc Xavier; Wernersson, Sara

Ingår i Developmental and Comparative Immunology, 2022

• DOI för Analysis of the mast cell expressed carboxypeptidase A3 and its structural and evolutionary relationship to other vertebrate carboxypeptidases
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Chicken cathepsin G-like - A highly specific serine protease with a peculiar tryptase specificity expressed by chicken thrombocytes

Fu, Zhirong; Akula, Srinivas; Olsson, Anna-Karin; Hellman, Lars

Ingår i Developmental and Comparative Immunology, 2022

• DOI för Chicken cathepsin G-like - A highly specific serine protease with a peculiar tryptase specificity expressed by chicken thrombocytes
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Extended cleavage specificity of a Chinese alligator granzyme B homologue, a strict Glu-ase in contrast to the mammalian Asp-ases

Ryu, Jinhye; Fu, Zhirong; Akula, Srinivas; Olsson, Anna-Karin et al.

Ingår i Developmental and Comparative Immunology, 2022

• DOI för Extended cleavage specificity of a Chinese alligator granzyme B homologue, a strict Glu-ase in contrast to the mammalian Asp-ases
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Platelet-Derived PDGFB Promotes Recruitment of Cancer-Associated Fibroblasts, Deposition of Extracellular Matrix and Tgf beta Signaling in the Tumor Microenvironment

Zhang, Yanyu; Doulabi, Ehsan Manouchehri; Herre, Melanie; Cedervall, Jessica et al.

Ingår i Cancers, 2022

• DOI för Platelet-Derived PDGFB Promotes Recruitment of Cancer-Associated Fibroblasts, Deposition of Extracellular Matrix and Tgf beta Signaling in the Tumor Microenvironment
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Quantitative Analysis of the Transcriptome of Two Commonly Used Human Monocytic Cell Lines-THP-1 and Mono Mac 6-Reveals Their Arrest during Early Monocyte/Neutrophil Differentiation

Akula, Srinivas; Lara, Sandra; Olsson, Anna-Karin; Hellman, Lars

Ingår i International Journal of Molecular Sciences, 2022

• DOI för Quantitative Analysis of the Transcriptome of Two Commonly Used Human Monocytic Cell Lines-THP-1 and Mono Mac 6-Reveals Their Arrest during Early Monocyte/Neutrophil Differentiation
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Quantitative In-Depth Transcriptome Analysis Implicates Peritoneal Macrophages as Important Players in the Complement and Coagulation Systems

Paivandy, Aida; Akula, Srinivas; Lara, Sandra; Fu, Zhirong et al.

Ingår i International Journal of Molecular Sciences, 2022

• DOI för Quantitative In-Depth Transcriptome Analysis Implicates Peritoneal Macrophages as Important Players in the Complement and Coagulation Systems
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Quantitative Transcriptome Analysis of Purified Equine Mast Cells Identifies a Dominant Mucosal Mast Cell Population with Possible Inflammatory Functions in Airways of Asthmatic Horses

Akula, Srinivas; Riihimaki, Miia; Waern, Ida; Abrink, Magnus et al.

Ingår i International Journal of Molecular Sciences, 2022

• DOI för Quantitative Transcriptome Analysis of Purified Equine Mast Cells Identifies a Dominant Mucosal Mast Cell Population with Possible Inflammatory Functions in Airways of Asthmatic Horses
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The Human Monocyte: A Circulating Sensor of Infection and a Potent and Rapid Inducer of Inflammation

Lara, Sandra; Akula, Srinivas; Fu, Zhirong; Olsson, Anna-Karin et al.

Ingår i International Journal of Molecular Sciences, 2022

• DOI för The Human Monocyte: A Circulating Sensor of Infection and a Potent and Rapid Inducer of Inflammation
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Vaccination against galectin-1 promotes cytotoxic T-cell infiltration in melanoma and reduces tumor burden

Femel, Julia; van Hooren, Luuk; Herre, Melanie; Cedervall, Jessica et al.

Ingår i Cancer Immunology and Immunotherapy, s. 2029-2040, 2022

• DOI för Vaccination against galectin-1 promotes cytotoxic T-cell infiltration in melanoma and reduces tumor burden
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Duodenases are a small subfamily of ruminant intestinal serine proteases that have undergone a remarkable diversification in cleavage specificity

Fu, Zhirong; Akula, Srinivas; Qiao, Chang; Ryu, Jinhye et al.

Ingår i PLOS ONE, 2021

• DOI för Duodenases are a small subfamily of ruminant intestinal serine proteases that have undergone a remarkable diversification in cleavage specificity
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Marked difference in efficiency of the digestive enzymes pepsin, trypsin, chymotrypsin, and pancreatic elastase to cleave tightly folded proteins

Fu, Zhirong; Akula, Srinivas; Thorpe, Michael; Hellman, Lars

Ingår i Biological chemistry (Print), s. 861-867, 2021

• DOI för Marked difference in efficiency of the digestive enzymes pepsin, trypsin, chymotrypsin, and pancreatic elastase to cleave tightly folded proteins
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Mast Cells and Basophils in the Defense against Ectoparasites: Efficient Degradation of Parasite Anticoagulants by the Connective Tissue Mast Cell Chymases

Fu, Zhirong; Akula, Srinivas; Olsson, Anna-Karin; Kervinen, Jukka et al.

Ingår i International Journal of Molecular Sciences, 2021

• DOI för Mast Cells and Basophils in the Defense against Ectoparasites: Efficient Degradation of Parasite Anticoagulants by the Connective Tissue Mast Cell Chymases
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Extended Cleavage Specificities of Two Mast Cell Chymase-Related Proteases and One Granzyme B-Like Protease from the Platypus, a Monotreme

Fu, Zhirong; Akula, Srinivas; Thorpe, Michael; Hellman, Lars

Ingår i International Journal of Molecular Sciences, 2020

• DOI för Extended Cleavage Specificities of Two Mast Cell Chymase-Related Proteases and One Granzyme B-Like Protease from the Platypus, a Monotreme
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Extended Cleavage Specificity of the Rat Vascular Chymase, a Potential Blood Pressure Regulating Enzyme Expressed by Rat Vascular Smooth Muscle Cells

Berglund, Petter; Akula, Srinivas; Fu, Zhirong; Thorpe, Michael et al.

Ingår i International Journal of Molecular Sciences, 2020

• DOI för Extended Cleavage Specificity of the Rat Vascular Chymase, a Potential Blood Pressure Regulating Enzyme Expressed by Rat Vascular Smooth Muscle Cells
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How Relevant Are Bone Marrow-Derived Mast Cells (BMMCs) as Models for Tissue Mast Cells?: A Comparative Transcriptome Analysis of BMMCs and Peritoneal Mast Cells

Akula, Srinivas; Paivandy, Aida; Fu, Zhirong; Thorpe, Michael et al.

Ingår i Cells, 2020

• DOI för How Relevant Are Bone Marrow-Derived Mast Cells (BMMCs) as Models for Tissue Mast Cells?: A Comparative Transcriptome Analysis of BMMCs and Peritoneal Mast Cells
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Mouse Strain-Dependent Difference Toward the Staphylococcus aureus Allergen Serine Protease-Like Protein D Reveals a Novel Regulator of IL-33

Teufelberger, Andrea R.; Van Nevel, Sharon; Hulpiau, Paco; Nordengrun, Maria et al.

Ingår i Frontiers in Immunology, 2020

• DOI för Mouse Strain-Dependent Difference Toward the Staphylococcus aureus Allergen Serine Protease-Like Protein D Reveals a Novel Regulator of IL-33
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Novel aspects of mast cell and basophil function: Highlights from the 9th meeting of the European Mast Cell and Basophil Research Network (EMBRN)-A Marcus Wallenberg Symposium

Hallgren, Jenny; Hellman, Lars; Maurer, Marcus; Nilsson, Gunnar P. et al.

Ingår i Allergy. European Journal of Allergy and Clinical Immunology, s. 707-708, 2020

• DOI för Novel aspects of mast cell and basophil function: Highlights from the 9th meeting of the European Mast Cell and Basophil Research Network (EMBRN)-A Marcus Wallenberg Symposium
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Potent and Broad but not Unselective Cleavage of Cytokines and Chemokines by Human Neutrophil Elastase and Proteinase 3

Fu, Zhirong; Akula, Srinivas; Thorpe, Michael; Hellman, Lars

Ingår i International Journal of Molecular Sciences, 2020

• DOI för Potent and Broad but not Unselective Cleavage of Cytokines and Chemokines by Human Neutrophil Elastase and Proteinase 3
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Protective role of mouse mast cell tryptase Mcpt6 in melanoma.

Grujic, Mirjana; Hellman, Lars; Gustafson, Ann-Marie; Akula, Srinivas et al.

Ingår i Pigment Cell & Melanoma Research, s. 579-590, 2020

• DOI för Protective role of mouse mast cell tryptase Mcpt6 in melanoma.

Quantitative In-Depth Analysis of the Mouse Mast Cell Transcriptome Reveals Organ-Specific Mast Cell Heterogeneity

Akula, Srinivas; Paivandy, Aida; Fu, Zhirong; Thorpe, Michael et al.

Ingår i CELLS, 2020

• DOI för Quantitative In-Depth Analysis of the Mouse Mast Cell Transcriptome Reveals Organ-Specific Mast Cell Heterogeneity
• Ladda ner fulltext (pdf) av Quantitative In-Depth Analysis of the Mouse Mast Cell Transcriptome Reveals Organ-Specific Mast Cell Heterogeneity

Cleavage specificity of recombinant Giardia intestinalis cysteine proteases: Degradation of immunoglobulins and defensins

Liu, Jingyi; Fu, Zhirong; Hellman, Lars; Svärd, Staffan G.

Ingår i Molecular and biochemical parasitology (Print), s. 29-38, 2019

• DOI för Cleavage specificity of recombinant Giardia intestinalis cysteine proteases: Degradation of immunoglobulins and defensins

Extended Cleavage Specificities of Rabbit and Guinea Pig Mast Cell Chymases: Two Highly Specific Leu-Ases

Zhongwei, Yuan; Akula, Srinivas; Fu, Zhirong; de Garavilla, Lawrence et al.

Ingår i International Journal of Molecular Sciences, 2019

• DOI för Extended Cleavage Specificities of Rabbit and Guinea Pig Mast Cell Chymases: Two Highly Specific Leu-Ases
• Ladda ner fulltext (pdf) av Extended Cleavage Specificities of Rabbit and Guinea Pig Mast Cell Chymases: Two Highly Specific Leu-Ases

Extended cleavage specificity of sheep mast cell protease-2: A classical chymase with preference to aromatic P1 substrate residues

Fu, Zhirong; Akula, Srinivas; Thorpe, Michael; Chahal, Gurdeep et al.

Ingår i Developmental and Comparative Immunology, s. 160-169, 2019

• DOI för Extended cleavage specificity of sheep mast cell protease-2: A classical chymase with preference to aromatic P1 substrate residues

Highly Selective Cleavage of TH2-Promoting Cytokines by the Human and the Mouse Mast Cell Tryptases, Indicating a Potent Negative Feedback Loop on TH2 Immunity

Fu, Zhirong; Akula, Srinivas; Thorpe, Michael; Hellman, Lars

Ingår i International Journal of Molecular Sciences, 2019

• DOI för Highly Selective Cleavage of TH2-Promoting Cytokines by the Human and the Mouse Mast Cell Tryptases, Indicating a Potent Negative Feedback Loop on TH2 Immunity
• Ladda ner fulltext (pdf) av Highly Selective Cleavage of TH2-Promoting Cytokines by the Human and the Mouse Mast Cell Tryptases, Indicating a Potent Negative Feedback Loop on TH2 Immunity

Extended cleavage specificities of mast cell proteases 1 and 2 from golden hamster: Classical chymase and an elastolytic protease comparable to rat and mouse MCP-5

Thorpe, Michael; Fu, Zhirong; Albat, Emanuelle; Akula, Srinivas et al.

Ingår i PLOS ONE, 2018

• DOI för Extended cleavage specificities of mast cell proteases 1 and 2 from golden hamster: Classical chymase and an elastolytic protease comparable to rat and mouse MCP-5
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Extended cleavage specificity of human neutrophil cathepsin G: A low activity protease with dual chymase and tryptase-type specificities

Thorpe, Michael; Fu, Zhirong; Chahal, Gurdeep; Akula, Srinivas et al.

Ingår i PLOS ONE, 2018

• DOI för Extended cleavage specificity of human neutrophil cathepsin G: A low activity protease with dual chymase and tryptase-type specificities

Extended Cleavage Specificity of Human Neutrophil Elastase, Human Proteinase 3, and Their Distant Ortholog Clawed Frog PR3-Three Elastases With Similar Primary but Different Extended Specificities and Stability

Fu, Zhirong; Thorpe, Michael; Akula, Srinivas; Chahal, Gurdeep et al.

Ingår i Frontiers in Immunology, 2018

• DOI för Extended Cleavage Specificity of Human Neutrophil Elastase, Human Proteinase 3, and Their Distant Ortholog Clawed Frog PR3-Three Elastases With Similar Primary but Different Extended Specificities and Stability
• Ladda ner fulltext (pdf) av Extended Cleavage Specificity of Human Neutrophil Elastase, Human Proteinase 3, and Their Distant Ortholog Clawed Frog PR3-Three Elastases With Similar Primary but Different Extended Specificities and Stability

Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines

Liu, Jingyi; Ma'ayeh, Showgy Y.; Peirasmaki, Dimitra; Lundstrom-Stadelmann, Britta et al.

Ingår i Virulence, s. 879-894, 2018

• DOI för Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines
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Development of a novel therapeutic vaccine carrier that sustains high antibody titers against several targets simultaneously

Saupe, Falk; Reichel, Matthias; Huijbers, Elisabeth J. M.; Femel, Julia et al.

Ingår i The FASEB Journal, s. 1204-1214, 2017

• DOI för Development of a novel therapeutic vaccine carrier that sustains high antibody titers against several targets simultaneously

Highly Selective Cleavage of Cytokines and Chemokines by the Human Mast Cell Chymase and Neutrophil Cathepsin G

Fu, Zhirong; Thorpe, Michael; Alemayehu, Rahel; Roy, Ananya et al.

Ingår i Journal of Immunology, s. 1474-1483, 2017

• DOI för Highly Selective Cleavage of Cytokines and Chemokines by the Human Mast Cell Chymase and Neutrophil Cathepsin G

Asp-ase Activity of the Opossum Granzyme B Supports the Role of Granzyme B as Part of Anti-Viral Immunity Already during Early Mammalian Evolution

Fu, Zhirong; Thorpe, Michael; Akula, Srinivas; Hellman, Lars

Ingår i PLOS ONE, 2016

• DOI för Asp-ase Activity of the Opossum Granzyme B Supports the Role of Granzyme B as Part of Anti-Viral Immunity Already during Early Mammalian Evolution
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Channel catfish granzyme-like I is a highly specific serine protease with metase activity that is expressed by fish NK-like cells

Thorpe, Michael; Akula, Srinivas; Hellman, Lars

Ingår i Developmental And Comparative Immunology, s. 84-95, 2016

• DOI för Channel catfish granzyme-like I is a highly specific serine protease with metase activity that is expressed by fish NK-like cells

Elimination Of Il-33 Inhibits Airways Hyperresponsiveness

Frodella, C. M.; Smith, B. J.; Hellman, Lars T.; Poynter, M. E. et al.

Ingår i American Journal of Respiratory and Critical Care Medicine, 2016

Identification of Biological and Pharmaceutical Mast Cell- and Basophil-Related Targets

Klein, O.; Ngo-Nyekel, F.; Stefanache, T.; Torres, R. et al.

Ingår i Scandinavian Journal of Immunology, s. 465-472, 2016

• DOI för Identification of Biological and Pharmaceutical Mast Cell- and Basophil-Related Targets

Granule Associated Serine Proteases of Hematopoietic Cells - An Analysis of Their Appearance and Diversification during Vertebrate Evolution

Akula, Srinivas; Thorpe, Michael; Boinapally, Vamsi; Hellman, Lars

Ingår i PLOS ONE, 2015

• DOI för Granule Associated Serine Proteases of Hematopoietic Cells - An Analysis of Their Appearance and Diversification during Vertebrate Evolution
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IgA deficiency in wolves from Canada and Scandinavia

Frankowiack, Marcel; Olsson, Mia; Cluff, H. Dean; Evans, Alina L. et al.

Ingår i Developmental and Comparative Immunology, s. 26-28, 2015

• DOI för IgA deficiency in wolves from Canada and Scandinavia

rMCP-2, the Major Rat Mucosal Mast Cell Protease, an Analysis of Its Extended Cleavage Specificity and Its Potential Role in Regulating Intestinal Permeability by the Cleavage of Cell Adhesion and Junction Proteins

Fu, Zhirong; Thorpe, Michael; Hellman, Lars

Ingår i PLOS ONE, 2015

• DOI för rMCP-2, the Major Rat Mucosal Mast Cell Protease, an Analysis of Its Extended Cleavage Specificity and Its Potential Role in Regulating Intestinal Permeability by the Cleavage of Cell Adhesion and Junction Proteins
• Ladda ner fulltext (pdf) av rMCP-2, the Major Rat Mucosal Mast Cell Protease, an Analysis of Its Extended Cleavage Specificity and Its Potential Role in Regulating Intestinal Permeability by the Cleavage of Cell Adhesion and Junction Proteins

The Importance of Exosite Interactions for Substrate Cleavage by Human Thrombin

Chahal, Gurdeep; Thorpe, Michael; Hellman, Lars

Ingår i PLOS ONE, 2015

• DOI för The Importance of Exosite Interactions for Substrate Cleavage by Human Thrombin
• Ladda ner fulltext (pdf) av The Importance of Exosite Interactions for Substrate Cleavage by Human Thrombin

Vaccination against IL-33 Inhibits Airway Hyperresponsiveness and Inflammation in a House Dust Mite Model of Asthma

Lei, Ying; Boinapally, Vamsi; Zoltowska, Anna; Adner, Mikael et al.

Ingår i PLOS ONE, 2015

• DOI för Vaccination against IL-33 Inhibits Airway Hyperresponsiveness and Inflammation in a House Dust Mite Model of Asthma
• Ladda ner fulltext (pdf) av Vaccination against IL-33 Inhibits Airway Hyperresponsiveness and Inflammation in a House Dust Mite Model of Asthma