Lars Hellman

Recirculating glass pipettes constitute a high risk when working with freshly isolated immune cells - the presence of bacterial pyrogenic material

Akula, Srinivas; Lara, Sandra; Olsson, Anna-Karin; Hellman, Lars

Ingår i Frontiers in Cellular and Infection Microbiology, 2025

• DOI för Recirculating glass pipettes constitute a high risk when working with freshly isolated immune cells - the presence of bacterial pyrogenic material
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Mast Cells are Dependent on Glucose Transporter 1 (GLUT1) and GLUT3 for IgE-mediated Activation

Grujic, Mirjana; Alim, Md Abdul; Hellman, Lars; Peterson, Magnus et al.

Ingår i Inflammation, s. 1820-1836, 2024

• DOI för Mast Cells are Dependent on Glucose Transporter 1 (GLUT1) and GLUT3 for IgE-mediated Activation
• Ladda ner fulltext (pdf) av Mast Cells are Dependent on Glucose Transporter 1 (GLUT1) and GLUT3 for IgE-mediated Activation

Extended Cleavage Specificity of two Hematopoietic Serine Proteases from a Ray-Finned Fish, the Spotted Gar (Lepisosteus oculatus)

Valentini, Paolo; Akula, Srinivas; Alvarado-Vazquez, Perla Abigail; Hallgren, Jenny et al.

Ingår i International Journal of Molecular Sciences, 2024

• DOI för Extended Cleavage Specificity of two Hematopoietic Serine Proteases from a Ray-Finned Fish, the Spotted Gar (Lepisosteus oculatus)
• Ladda ner fulltext (pdf) av Extended Cleavage Specificity of two Hematopoietic Serine Proteases from a Ray-Finned Fish, the Spotted Gar (Lepisosteus oculatus)

Characterization of Freshly Isolated Human Peripheral Blood B Cells, Monocytes, CD4⁺ and CD8⁺ T Cells, and Skin Mast Cells by Quantitative Transcriptomics

Akula, Srinivas; Alvarado-Vazquez, Abigail; Mendez Enriquez, Erika Haide; Bal, Gürkan et al.

Ingår i International Journal of Molecular Sciences, 2024

• DOI för Characterization of Freshly Isolated Human Peripheral Blood B Cells, Monocytes, CD4⁺ and CD8⁺ T Cells, and Skin Mast Cells by Quantitative Transcriptomics
• Ladda ner fulltext (pdf) av Characterization of Freshly Isolated Human Peripheral Blood B Cells, Monocytes, CD4⁺ and CD8⁺ T Cells, and Skin Mast Cells by Quantitative Transcriptomics

The Extended Cleavage Specificity of Channel Catfish Granzyme-like II, A Highly Specific Elastase, Expressed by Natural Killer-like Cells

Thorpe, Michael; Akula, Srinivas; Fu, Zhirong; Hellman, Lars

Ingår i International Journal of Molecular Sciences, 2024

• DOI för The Extended Cleavage Specificity of Channel Catfish Granzyme-like II, A Highly Specific Elastase, Expressed by Natural Killer-like Cells
• Ladda ner fulltext (pdf) av The Extended Cleavage Specificity of Channel Catfish Granzyme-like II, A Highly Specific Elastase, Expressed by Natural Killer-like Cells

Recirculating glass pipettes constitute a high risk when working with freshly isolated immune cells - the presence of bacterial pyrogenic material

Akula, Srinivas; Lara, Sandra; Olsson, Anna-Karin; Hellman, Lars

Ingår i Frontiers in Cellular and Infection Microbiology, 2025

• DOI för Recirculating glass pipettes constitute a high risk when working with freshly isolated immune cells - the presence of bacterial pyrogenic material
• Ladda ner fulltext (pdf) av Recirculating glass pipettes constitute a high risk when working with freshly isolated immune cells - the presence of bacterial pyrogenic material

Mast Cells are Dependent on Glucose Transporter 1 (GLUT1) and GLUT3 for IgE-mediated Activation

Grujic, Mirjana; Alim, Md Abdul; Hellman, Lars; Peterson, Magnus et al.

Ingår i Inflammation, s. 1820-1836, 2024

• DOI för Mast Cells are Dependent on Glucose Transporter 1 (GLUT1) and GLUT3 for IgE-mediated Activation
• Ladda ner fulltext (pdf) av Mast Cells are Dependent on Glucose Transporter 1 (GLUT1) and GLUT3 for IgE-mediated Activation

Extended Cleavage Specificity of two Hematopoietic Serine Proteases from a Ray-Finned Fish, the Spotted Gar (Lepisosteus oculatus)

Valentini, Paolo; Akula, Srinivas; Alvarado-Vazquez, Perla Abigail; Hallgren, Jenny et al.

Ingår i International Journal of Molecular Sciences, 2024

• DOI för Extended Cleavage Specificity of two Hematopoietic Serine Proteases from a Ray-Finned Fish, the Spotted Gar (Lepisosteus oculatus)
• Ladda ner fulltext (pdf) av Extended Cleavage Specificity of two Hematopoietic Serine Proteases from a Ray-Finned Fish, the Spotted Gar (Lepisosteus oculatus)

Characterization of Freshly Isolated Human Peripheral Blood B Cells, Monocytes, CD4⁺ and CD8⁺ T Cells, and Skin Mast Cells by Quantitative Transcriptomics

Akula, Srinivas; Alvarado-Vazquez, Abigail; Mendez Enriquez, Erika Haide; Bal, Gürkan et al.

Ingår i International Journal of Molecular Sciences, 2024

• DOI för Characterization of Freshly Isolated Human Peripheral Blood B Cells, Monocytes, CD4⁺ and CD8⁺ T Cells, and Skin Mast Cells by Quantitative Transcriptomics
• Ladda ner fulltext (pdf) av Characterization of Freshly Isolated Human Peripheral Blood B Cells, Monocytes, CD4⁺ and CD8⁺ T Cells, and Skin Mast Cells by Quantitative Transcriptomics

The Extended Cleavage Specificity of Channel Catfish Granzyme-like II, A Highly Specific Elastase, Expressed by Natural Killer-like Cells

Thorpe, Michael; Akula, Srinivas; Fu, Zhirong; Hellman, Lars

Ingår i International Journal of Molecular Sciences, 2024

• DOI för The Extended Cleavage Specificity of Channel Catfish Granzyme-like II, A Highly Specific Elastase, Expressed by Natural Killer-like Cells
• Ladda ner fulltext (pdf) av The Extended Cleavage Specificity of Channel Catfish Granzyme-like II, A Highly Specific Elastase, Expressed by Natural Killer-like Cells

Cultures of Human Skin Mast Cells, an Attractive In Vitro Model for Studies of Human Mast Cell Biology

Akula, Srinivas; Tripathi, Shiva Raj; Franke, Kristin; Wernersson, Sara et al.

Ingår i Cells, 2024

• DOI för Cultures of Human Skin Mast Cells, an Attractive In Vitro Model for Studies of Human Mast Cell Biology
• Ladda ner fulltext (pdf) av Cultures of Human Skin Mast Cells, an Attractive In Vitro Model for Studies of Human Mast Cell Biology

Extended cleavage specificities of human granzymes A and K, two closely related enzymes with conserved but still poorly defined functions in T and NK cell-mediated immunity

Aybay, Erdem; Ryu, Jinhye; Fu, Zhirong; Akula, Srinivas et al.

Ingår i Frontiers in Immunology, 2023

• DOI för Extended cleavage specificities of human granzymes A and K, two closely related enzymes with conserved but still poorly defined functions in T and NK cell-mediated immunity
• Ladda ner fulltext (pdf) av Extended cleavage specificities of human granzymes A and K, two closely related enzymes with conserved but still poorly defined functions in T and NK cell-mediated immunity

Two granzyme A/K homologs in Zebra mbuna have different specificities, one classical tryptase and one with chymase activity

Aybay, Erdem; Elkhalifa, Mamoun; Akula, Srinivas; Wernersson, Sara et al.

Ingår i Developmental and Comparative Immunology, 2023

• DOI för Two granzyme A/K homologs in Zebra mbuna have different specificities, one classical tryptase and one with chymase activity
• Ladda ner fulltext (pdf) av Two granzyme A/K homologs in Zebra mbuna have different specificities, one classical tryptase and one with chymase activity

Identification of the Major Protein Components of Human and Cow Saliva

Akula, Srinivas; Welinder, Charlotte; Fu, Zhirong; Olsson, Anna-Karin et al.

Ingår i International Journal of Molecular Sciences, 2023

• DOI för Identification of the Major Protein Components of Human and Cow Saliva
• Ladda ner fulltext (pdf) av Identification of the Major Protein Components of Human and Cow Saliva

Phenotypic and Functional Heterogeneity of Monocytes and Macrophages

Hellman, Lars

Ingår i International Journal of Molecular Sciences, 2023

• DOI för Phenotypic and Functional Heterogeneity of Monocytes and Macrophages
• Ladda ner fulltext (pdf) av Phenotypic and Functional Heterogeneity of Monocytes and Macrophages

Single-cell transcriptomics delineates the immune cell landscape in equine lower airways and reveals upregulation of FKBP5 in horses with asthma.

Riihimäki, Miia; Fegraeus, K. Jaderkvist; Nordlund, Jessica; Waern, Ida et al.

Ingår i Scientific Reports, s. 16261, 2023

• DOI för Single-cell transcriptomics delineates the immune cell landscape in equine lower airways and reveals upregulation of FKBP5 in horses with asthma.
• Ladda ner fulltext (pdf) av Single-cell transcriptomics delineates the immune cell landscape in equine lower airways and reveals upregulation of FKBP5 in horses with asthma.

House Dust Mite and Cat Dander Extract Induce Asthma-Like Histopathology with an Increase of Mucosal Mast Cells in a Guinea Pig Model

Ramos-Ramirez, Patricia; Liu, Jielu; Mogren, Sofia; Gregory, Joshua et al.

Ingår i Journal of Immunology Research, 2023

• DOI för House Dust Mite and Cat Dander Extract Induce Asthma-Like Histopathology with an Increase of Mucosal Mast Cells in a Guinea Pig Model
• Ladda ner fulltext (pdf) av House Dust Mite and Cat Dander Extract Induce Asthma-Like Histopathology with an Increase of Mucosal Mast Cells in a Guinea Pig Model

Extended cleavage specificity of a Chinese alligator granzyme B homologue, a strict Glu-ase in contrast to the mammalian Asp-ases

Ryu, Jinhye; Fu, Zhirong; Akula, Srinivas; Olsson, Anna-Karin et al.

Ingår i Developmental and Comparative Immunology, 2022

• DOI för Extended cleavage specificity of a Chinese alligator granzyme B homologue, a strict Glu-ase in contrast to the mammalian Asp-ases
• Ladda ner fulltext (pdf) av Extended cleavage specificity of a Chinese alligator granzyme B homologue, a strict Glu-ase in contrast to the mammalian Asp-ases

Quantitative In-Depth Transcriptome Analysis Implicates Peritoneal Macrophages as Important Players in the Complement and Coagulation Systems

Paivandy, Aida; Akula, Srinivas; Lara, Sandra; Fu, Zhirong et al.

Ingår i International Journal of Molecular Sciences, 2022

• DOI för Quantitative In-Depth Transcriptome Analysis Implicates Peritoneal Macrophages as Important Players in the Complement and Coagulation Systems
• Ladda ner fulltext (pdf) av Quantitative In-Depth Transcriptome Analysis Implicates Peritoneal Macrophages as Important Players in the Complement and Coagulation Systems

Quantitative Analysis of the Transcriptome of Two Commonly Used Human Monocytic Cell Lines-THP-1 and Mono Mac 6-Reveals Their Arrest during Early Monocyte/Neutrophil Differentiation

Akula, Srinivas; Lara, Sandra; Olsson, Anna-Karin; Hellman, Lars

Ingår i International Journal of Molecular Sciences, 2022

• DOI för Quantitative Analysis of the Transcriptome of Two Commonly Used Human Monocytic Cell Lines-THP-1 and Mono Mac 6-Reveals Their Arrest during Early Monocyte/Neutrophil Differentiation
• Ladda ner fulltext (pdf) av Quantitative Analysis of the Transcriptome of Two Commonly Used Human Monocytic Cell Lines-THP-1 and Mono Mac 6-Reveals Their Arrest during Early Monocyte/Neutrophil Differentiation

Platelet-Derived PDGFB Promotes Recruitment of Cancer-Associated Fibroblasts, Deposition of Extracellular Matrix and Tgf beta Signaling in the Tumor Microenvironment

Zhang, Yanyu; Doulabi, Ehsan Manouchehri; Herre, Melanie; Cedervall, Jessica et al.

Ingår i Cancers, 2022

• DOI för Platelet-Derived PDGFB Promotes Recruitment of Cancer-Associated Fibroblasts, Deposition of Extracellular Matrix and Tgf beta Signaling in the Tumor Microenvironment
• Ladda ner fulltext (pdf) av Platelet-Derived PDGFB Promotes Recruitment of Cancer-Associated Fibroblasts, Deposition of Extracellular Matrix and Tgf beta Signaling in the Tumor Microenvironment

The Human Monocyte: A Circulating Sensor of Infection and a Potent and Rapid Inducer of Inflammation

Lara, Sandra; Akula, Srinivas; Fu, Zhirong; Olsson, Anna-Karin et al.

Ingår i International Journal of Molecular Sciences, 2022

• DOI för The Human Monocyte: A Circulating Sensor of Infection and a Potent and Rapid Inducer of Inflammation
• Ladda ner fulltext (pdf) av The Human Monocyte: A Circulating Sensor of Infection and a Potent and Rapid Inducer of Inflammation

Analysis of the mast cell expressed carboxypeptidase A3 and its structural and evolutionary relationship to other vertebrate carboxypeptidases

Akula, Srinivas; Hellman, Lars; Aviles, Francesc Xavier; Wernersson, Sara

Ingår i Developmental and Comparative Immunology, 2022

• DOI för Analysis of the mast cell expressed carboxypeptidase A3 and its structural and evolutionary relationship to other vertebrate carboxypeptidases
• Ladda ner fulltext (pdf) av Analysis of the mast cell expressed carboxypeptidase A3 and its structural and evolutionary relationship to other vertebrate carboxypeptidases

Chicken cathepsin G-like - A highly specific serine protease with a peculiar tryptase specificity expressed by chicken thrombocytes

Fu, Zhirong; Akula, Srinivas; Olsson, Anna-Karin; Hellman, Lars

Ingår i Developmental and Comparative Immunology, 2022

• DOI för Chicken cathepsin G-like - A highly specific serine protease with a peculiar tryptase specificity expressed by chicken thrombocytes
• Ladda ner fulltext (pdf) av Chicken cathepsin G-like - A highly specific serine protease with a peculiar tryptase specificity expressed by chicken thrombocytes

Quantitative Transcriptome Analysis of Purified Equine Mast Cells Identifies a Dominant Mucosal Mast Cell Population with Possible Inflammatory Functions in Airways of Asthmatic Horses

Akula, Srinivas; Riihimaki, Miia; Waern, Ida; Abrink, Magnus et al.

Ingår i International Journal of Molecular Sciences, 2022

• DOI för Quantitative Transcriptome Analysis of Purified Equine Mast Cells Identifies a Dominant Mucosal Mast Cell Population with Possible Inflammatory Functions in Airways of Asthmatic Horses
• Ladda ner fulltext (pdf) av Quantitative Transcriptome Analysis of Purified Equine Mast Cells Identifies a Dominant Mucosal Mast Cell Population with Possible Inflammatory Functions in Airways of Asthmatic Horses

Vaccination against galectin-1 promotes cytotoxic T-cell infiltration in melanoma and reduces tumor burden

Femel, Julia; van Hooren, Luuk; Herre, Melanie; Cedervall, Jessica et al.

Ingår i Cancer Immunology and Immunotherapy, s. 2029-2040, 2022

• DOI för Vaccination against galectin-1 promotes cytotoxic T-cell infiltration in melanoma and reduces tumor burden
• Ladda ner fulltext (pdf) av Vaccination against galectin-1 promotes cytotoxic T-cell infiltration in melanoma and reduces tumor burden

Duodenases are a small subfamily of ruminant intestinal serine proteases that have undergone a remarkable diversification in cleavage specificity

Fu, Zhirong; Akula, Srinivas; Qiao, Chang; Ryu, Jinhye et al.

Ingår i PLOS ONE, 2021

• DOI för Duodenases are a small subfamily of ruminant intestinal serine proteases that have undergone a remarkable diversification in cleavage specificity
• Ladda ner fulltext (pdf) av Duodenases are a small subfamily of ruminant intestinal serine proteases that have undergone a remarkable diversification in cleavage specificity

Marked difference in efficiency of the digestive enzymes pepsin, trypsin, chymotrypsin, and pancreatic elastase to cleave tightly folded proteins

Fu, Zhirong; Akula, Srinivas; Thorpe, Michael; Hellman, Lars

Ingår i Biological chemistry (Print), s. 861-867, 2021

• DOI för Marked difference in efficiency of the digestive enzymes pepsin, trypsin, chymotrypsin, and pancreatic elastase to cleave tightly folded proteins
• Ladda ner fulltext (pdf) av Marked difference in efficiency of the digestive enzymes pepsin, trypsin, chymotrypsin, and pancreatic elastase to cleave tightly folded proteins

Mast Cells and Basophils in the Defense against Ectoparasites: Efficient Degradation of Parasite Anticoagulants by the Connective Tissue Mast Cell Chymases

Fu, Zhirong; Akula, Srinivas; Olsson, Anna-Karin; Kervinen, Jukka et al.

Ingår i International Journal of Molecular Sciences, 2021

• DOI för Mast Cells and Basophils in the Defense against Ectoparasites: Efficient Degradation of Parasite Anticoagulants by the Connective Tissue Mast Cell Chymases
• Ladda ner fulltext (pdf) av Mast Cells and Basophils in the Defense against Ectoparasites: Efficient Degradation of Parasite Anticoagulants by the Connective Tissue Mast Cell Chymases

Extended Cleavage Specificity of the Rat Vascular Chymase, a Potential Blood Pressure Regulating Enzyme Expressed by Rat Vascular Smooth Muscle Cells

Berglund, Petter; Akula, Srinivas; Fu, Zhirong; Thorpe, Michael et al.

Ingår i International Journal of Molecular Sciences, 2020

• DOI för Extended Cleavage Specificity of the Rat Vascular Chymase, a Potential Blood Pressure Regulating Enzyme Expressed by Rat Vascular Smooth Muscle Cells
• Ladda ner fulltext (pdf) av Extended Cleavage Specificity of the Rat Vascular Chymase, a Potential Blood Pressure Regulating Enzyme Expressed by Rat Vascular Smooth Muscle Cells

Extended Cleavage Specificities of Two Mast Cell Chymase-Related Proteases and One Granzyme B-Like Protease from the Platypus, a Monotreme

Fu, Zhirong; Akula, Srinivas; Thorpe, Michael; Hellman, Lars

Ingår i International Journal of Molecular Sciences, 2020

• DOI för Extended Cleavage Specificities of Two Mast Cell Chymase-Related Proteases and One Granzyme B-Like Protease from the Platypus, a Monotreme
• Ladda ner fulltext (pdf) av Extended Cleavage Specificities of Two Mast Cell Chymase-Related Proteases and One Granzyme B-Like Protease from the Platypus, a Monotreme

Mouse Strain-Dependent Difference Toward the Staphylococcus aureus Allergen Serine Protease-Like Protein D Reveals a Novel Regulator of IL-33

Teufelberger, Andrea R.; Van Nevel, Sharon; Hulpiau, Paco; Nordengrun, Maria et al.

Ingår i Frontiers in Immunology, 2020

• DOI för Mouse Strain-Dependent Difference Toward the Staphylococcus aureus Allergen Serine Protease-Like Protein D Reveals a Novel Regulator of IL-33
• Ladda ner fulltext (pdf) av Mouse Strain-Dependent Difference Toward the Staphylococcus aureus Allergen Serine Protease-Like Protein D Reveals a Novel Regulator of IL-33

Potent and Broad but not Unselective Cleavage of Cytokines and Chemokines by Human Neutrophil Elastase and Proteinase 3

Fu, Zhirong; Akula, Srinivas; Thorpe, Michael; Hellman, Lars

Ingår i International Journal of Molecular Sciences, 2020

• DOI för Potent and Broad but not Unselective Cleavage of Cytokines and Chemokines by Human Neutrophil Elastase and Proteinase 3
• Ladda ner fulltext (pdf) av Potent and Broad but not Unselective Cleavage of Cytokines and Chemokines by Human Neutrophil Elastase and Proteinase 3

Protective role of mouse mast cell tryptase Mcpt6 in melanoma.

Grujic, Mirjana; Hellman, Lars; Gustafson, Ann-Marie; Akula, Srinivas et al.

Ingår i Pigment Cell & Melanoma Research, s. 579-590, 2020

• DOI för Protective role of mouse mast cell tryptase Mcpt6 in melanoma.

How Relevant Are Bone Marrow-Derived Mast Cells (BMMCs) as Models for Tissue Mast Cells?: A Comparative Transcriptome Analysis of BMMCs and Peritoneal Mast Cells

Akula, Srinivas; Paivandy, Aida; Fu, Zhirong; Thorpe, Michael et al.

Ingår i Cells, 2020

• DOI för How Relevant Are Bone Marrow-Derived Mast Cells (BMMCs) as Models for Tissue Mast Cells?: A Comparative Transcriptome Analysis of BMMCs and Peritoneal Mast Cells
• Ladda ner fulltext (pdf) av How Relevant Are Bone Marrow-Derived Mast Cells (BMMCs) as Models for Tissue Mast Cells?: A Comparative Transcriptome Analysis of BMMCs and Peritoneal Mast Cells

Novel aspects of mast cell and basophil function: Highlights from the 9th meeting of the European Mast Cell and Basophil Research Network (EMBRN)-A Marcus Wallenberg Symposium

Hallgren, Jenny; Hellman, Lars; Maurer, Marcus; Nilsson, Gunnar P. et al.

Ingår i Allergy. European Journal of Allergy and Clinical Immunology, s. 707-708, 2020

• DOI för Novel aspects of mast cell and basophil function: Highlights from the 9th meeting of the European Mast Cell and Basophil Research Network (EMBRN)-A Marcus Wallenberg Symposium
• Ladda ner fulltext (pdf) av Novel aspects of mast cell and basophil function: Highlights from the 9th meeting of the European Mast Cell and Basophil Research Network (EMBRN)-A Marcus Wallenberg Symposium

Quantitative In-Depth Analysis of the Mouse Mast Cell Transcriptome Reveals Organ-Specific Mast Cell Heterogeneity

Akula, Srinivas; Paivandy, Aida; Fu, Zhirong; Thorpe, Michael et al.

Ingår i CELLS, 2020

• DOI för Quantitative In-Depth Analysis of the Mouse Mast Cell Transcriptome Reveals Organ-Specific Mast Cell Heterogeneity
• Ladda ner fulltext (pdf) av Quantitative In-Depth Analysis of the Mouse Mast Cell Transcriptome Reveals Organ-Specific Mast Cell Heterogeneity

Highly Selective Cleavage of TH2-Promoting Cytokines by the Human and the Mouse Mast Cell Tryptases, Indicating a Potent Negative Feedback Loop on TH2 Immunity

Fu, Zhirong; Akula, Srinivas; Thorpe, Michael; Hellman, Lars

Ingår i International Journal of Molecular Sciences, 2019

• DOI för Highly Selective Cleavage of TH2-Promoting Cytokines by the Human and the Mouse Mast Cell Tryptases, Indicating a Potent Negative Feedback Loop on TH2 Immunity
• Ladda ner fulltext (pdf) av Highly Selective Cleavage of TH2-Promoting Cytokines by the Human and the Mouse Mast Cell Tryptases, Indicating a Potent Negative Feedback Loop on TH2 Immunity

Extended Cleavage Specificities of Rabbit and Guinea Pig Mast Cell Chymases: Two Highly Specific Leu-Ases

Zhongwei, Yuan; Akula, Srinivas; Fu, Zhirong; de Garavilla, Lawrence et al.

Ingår i International Journal of Molecular Sciences, 2019

• DOI för Extended Cleavage Specificities of Rabbit and Guinea Pig Mast Cell Chymases: Two Highly Specific Leu-Ases
• Ladda ner fulltext (pdf) av Extended Cleavage Specificities of Rabbit and Guinea Pig Mast Cell Chymases: Two Highly Specific Leu-Ases

Extended cleavage specificity of sheep mast cell protease-2: A classical chymase with preference to aromatic P1 substrate residues

Fu, Zhirong; Akula, Srinivas; Thorpe, Michael; Chahal, Gurdeep et al.

Ingår i Developmental and Comparative Immunology, s. 160-169, 2019

• DOI för Extended cleavage specificity of sheep mast cell protease-2: A classical chymase with preference to aromatic P1 substrate residues

Cleavage specificity of recombinant Giardia intestinalis cysteine proteases: Degradation of immunoglobulins and defensins

Liu, Jingyi; Fu, Zhirong; Hellman, Lars; Svärd, Staffan G.

Ingår i Molecular and biochemical parasitology (Print), s. 29-38, 2019

• DOI för Cleavage specificity of recombinant Giardia intestinalis cysteine proteases: Degradation of immunoglobulins and defensins

Extended cleavage specificities of mast cell proteases 1 and 2 from golden hamster: Classical chymase and an elastolytic protease comparable to rat and mouse MCP-5

Thorpe, Michael; Fu, Zhirong; Albat, Emanuelle; Akula, Srinivas et al.

Ingår i PLOS ONE, 2018

• DOI för Extended cleavage specificities of mast cell proteases 1 and 2 from golden hamster: Classical chymase and an elastolytic protease comparable to rat and mouse MCP-5
• Ladda ner fulltext (pdf) av Extended cleavage specificities of mast cell proteases 1 and 2 from golden hamster: Classical chymase and an elastolytic protease comparable to rat and mouse MCP-5

Extended cleavage specificity of human neutrophil cathepsin G: A low activity protease with dual chymase and tryptase-type specificities

Thorpe, Michael; Fu, Zhirong; Chahal, Gurdeep; Akula, Srinivas et al.

Ingår i PLOS ONE, 2018

• DOI för Extended cleavage specificity of human neutrophil cathepsin G: A low activity protease with dual chymase and tryptase-type specificities

Extended Cleavage Specificity of Human Neutrophil Elastase, Human Proteinase 3, and Their Distant Ortholog Clawed Frog PR3-Three Elastases With Similar Primary but Different Extended Specificities and Stability

Fu, Zhirong; Thorpe, Michael; Akula, Srinivas; Chahal, Gurdeep et al.

Ingår i Frontiers in Immunology, 2018

• DOI för Extended Cleavage Specificity of Human Neutrophil Elastase, Human Proteinase 3, and Their Distant Ortholog Clawed Frog PR3-Three Elastases With Similar Primary but Different Extended Specificities and Stability
• Ladda ner fulltext (pdf) av Extended Cleavage Specificity of Human Neutrophil Elastase, Human Proteinase 3, and Their Distant Ortholog Clawed Frog PR3-Three Elastases With Similar Primary but Different Extended Specificities and Stability

Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines

Liu, Jingyi; Ma'ayeh, Showgy Y.; Peirasmaki, Dimitra; Lundstrom-Stadelmann, Britta et al.

Ingår i Virulence, s. 879-894, 2018

• DOI för Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines
• Ladda ner fulltext (pdf) av Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines

Development of a novel therapeutic vaccine carrier that sustains high antibody titers against several targets simultaneously

Saupe, Falk; Reichel, Matthias; Huijbers, Elisabeth J. M.; Femel, Julia et al.

Ingår i The FASEB Journal, s. 1204-1214, 2017

• DOI för Development of a novel therapeutic vaccine carrier that sustains high antibody titers against several targets simultaneously

Highly Selective Cleavage of Cytokines and Chemokines by the Human Mast Cell Chymase and Neutrophil Cathepsin G

Fu, Zhirong; Thorpe, Michael; Alemayehu, Rahel; Roy, Ananya et al.

Ingår i Journal of Immunology, s. 1474-1483, 2017

• DOI för Highly Selective Cleavage of Cytokines and Chemokines by the Human Mast Cell Chymase and Neutrophil Cathepsin G

Asp-ase Activity of the Opossum Granzyme B Supports the Role of Granzyme B as Part of Anti-Viral Immunity Already during Early Mammalian Evolution

Fu, Zhirong; Thorpe, Michael; Akula, Srinivas; Hellman, Lars

Ingår i PLOS ONE, 2016

• DOI för Asp-ase Activity of the Opossum Granzyme B Supports the Role of Granzyme B as Part of Anti-Viral Immunity Already during Early Mammalian Evolution
• Ladda ner fulltext (pdf) av Asp-ase Activity of the Opossum Granzyme B Supports the Role of Granzyme B as Part of Anti-Viral Immunity Already during Early Mammalian Evolution

Channel catfish granzyme-like I is a highly specific serine protease with metase activity that is expressed by fish NK-like cells

Thorpe, Michael; Akula, Srinivas; Hellman, Lars

Ingår i Developmental And Comparative Immunology, s. 84-95, 2016

• DOI för Channel catfish granzyme-like I is a highly specific serine protease with metase activity that is expressed by fish NK-like cells

Identification of Biological and Pharmaceutical Mast Cell- and Basophil-Related Targets

Klein, O.; Ngo-Nyekel, F.; Stefanache, T.; Torres, R. et al.

Ingår i Scandinavian Journal of Immunology, s. 465-472, 2016

• DOI för Identification of Biological and Pharmaceutical Mast Cell- and Basophil-Related Targets

Elimination Of Il-33 Inhibits Airways Hyperresponsiveness

Frodella, C. M.; Smith, B. J.; Hellman, Lars T.; Poynter, M. E. et al.

Ingår i American Journal of Respiratory and Critical Care Medicine, 2016

rMCP-2, the Major Rat Mucosal Mast Cell Protease, an Analysis of Its Extended Cleavage Specificity and Its Potential Role in Regulating Intestinal Permeability by the Cleavage of Cell Adhesion and Junction Proteins

Fu, Zhirong; Thorpe, Michael; Hellman, Lars

Ingår i PLOS ONE, 2015

• DOI för rMCP-2, the Major Rat Mucosal Mast Cell Protease, an Analysis of Its Extended Cleavage Specificity and Its Potential Role in Regulating Intestinal Permeability by the Cleavage of Cell Adhesion and Junction Proteins
• Ladda ner fulltext (pdf) av rMCP-2, the Major Rat Mucosal Mast Cell Protease, an Analysis of Its Extended Cleavage Specificity and Its Potential Role in Regulating Intestinal Permeability by the Cleavage of Cell Adhesion and Junction Proteins

Granule Associated Serine Proteases of Hematopoietic Cells - An Analysis of Their Appearance and Diversification during Vertebrate Evolution

Akula, Srinivas; Thorpe, Michael; Boinapally, Vamsi; Hellman, Lars

Ingår i PLOS ONE, 2015

• DOI för Granule Associated Serine Proteases of Hematopoietic Cells - An Analysis of Their Appearance and Diversification during Vertebrate Evolution
• Ladda ner fulltext (pdf) av Granule Associated Serine Proteases of Hematopoietic Cells - An Analysis of Their Appearance and Diversification during Vertebrate Evolution

The Importance of Exosite Interactions for Substrate Cleavage by Human Thrombin

Chahal, Gurdeep; Thorpe, Michael; Hellman, Lars

Ingår i PLOS ONE, 2015

• DOI för The Importance of Exosite Interactions for Substrate Cleavage by Human Thrombin
• Ladda ner fulltext (pdf) av The Importance of Exosite Interactions for Substrate Cleavage by Human Thrombin

Vaccination against IL-33 Inhibits Airway Hyperresponsiveness and Inflammation in a House Dust Mite Model of Asthma

Lei, Ying; Boinapally, Vamsi; Zoltowska, Anna; Adner, Mikael et al.

Ingår i PLOS ONE, 2015

• DOI för Vaccination against IL-33 Inhibits Airway Hyperresponsiveness and Inflammation in a House Dust Mite Model of Asthma
• Ladda ner fulltext (pdf) av Vaccination against IL-33 Inhibits Airway Hyperresponsiveness and Inflammation in a House Dust Mite Model of Asthma

IgA deficiency in wolves from Canada and Scandinavia

Frankowiack, Marcel; Olsson, Mia; Cluff, H. Dean; Evans, Alina L. et al.

Ingår i Developmental and Comparative Immunology, s. 26-28, 2015

• DOI för IgA deficiency in wolves from Canada and Scandinavia

Therapeutic vaccination against fibronectin ED-A attenuates progression of metastatic breast cancer.

Femel, Julia; Huijbers, Elisabeth JM; Saupe, Falk; Cedervall, Jessica et al.

Ingår i Oncotarget, s. 12418-12427, 2014

• Ladda ner fulltext (pdf) av Therapeutic vaccination against fibronectin ED-A attenuates progression of metastatic breast cancer.

Progression of metastatic breast cancer can be attenuated by therapeutic vaccination against the tumor vascular marker ED-A

Femel, Julia; Huijbers, Elisabeth J. M.; Saupe, Falk; Cedervall, Jessica et al.

Ingår i Angiogenesis, s. 769-769, 2014

Fc Receptors for Immunoglobulins and Their Appearance during Vertebrate Evolution

Akula, Srinivas; Mohammadamin, Sayran; Hellman, Lars

Ingår i PLOS ONE, 2014

• DOI för Fc Receptors for Immunoglobulins and Their Appearance during Vertebrate Evolution
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Mast Cell Chymase Degrades the Alarmins Heat Shock Protein 70, Biglycan, HMGB1, and Interleukin-33 (IL-33) and Limits Danger-induced Inflammation

Roy, Ananya; Ganesh, Goutham; Sippola, Helena; Bolin, Sara et al.

Ingår i Journal of Biological Chemistry, s. 237-250, 2014

• DOI för Mast Cell Chymase Degrades the Alarmins Heat Shock Protein 70, Biglycan, HMGB1, and Interleukin-33 (IL-33) and Limits Danger-induced Inflammation

Characterization of an Experimental Vaccine for Bovine Respiratory Syncytial Virus

Hagglund, Sara; Hu, Kefei; Blodorn, Krister; Makabi-Panzu, Boby et al.

Ingår i Clinical and Vaccine Immunology, s. 997-1004, 2014

• DOI för Characterization of an Experimental Vaccine for Bovine Respiratory Syncytial Virus

Mutations in Arg143 and Lys192 of the Human Mast Cell Chymase Markedly Affect the Activity of Five Potent Human Chymase Inhibitors

Ahooghalandari, Parvin; Hanke, Nina; Thorpe, Michael; Witte, Andreas et al.

Ingår i PLOS ONE, 2013

• DOI för Mutations in Arg143 and Lys192 of the Human Mast Cell Chymase Markedly Affect the Activity of Five Potent Human Chymase Inhibitors
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IgA deficiency in wolves

Frankowiack, Marcel; Hellman, Lars; Zhao, Yaofeng; Arnemo, Jon M. et al.

Ingår i Developmental and Comparative Immunology, s. 180-184, 2013

• DOI för IgA deficiency in wolves

The Extended Cleavage Specificity of Human Thrombin

Gallwitz, Maike; Enoksson, Mattias; Thorpe, Michael; Hellman, Lars

Ingår i PLOS ONE, 2012

• DOI för The Extended Cleavage Specificity of Human Thrombin
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Human Cord Blood Derived Immature Basophils Show Dual Characteristics, Expressing Both Basophil and Eosinophil Associated Proteins

Grundström, Jeanette; Reimer, Jenny M.; Magnusson, Sofia E.; Nilsson, Gunnar et al.

Ingår i PLOS ONE, 2012

• DOI för Human Cord Blood Derived Immature Basophils Show Dual Characteristics, Expressing Both Basophil and Eosinophil Associated Proteins
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Mast cells limit extracellular levels of IL-13 via a serglycin proteoglycan-serine protease axis

Waern, Ida; Karlsson, Iulia; Thorpe, Michael; Schlenner, Susan M. et al.

Ingår i Biological chemistry (Print), s. 1555-1567, 2012

• DOI för Mast cells limit extracellular levels of IL-13 via a serglycin proteoglycan-serine protease axis

The non-toxic and biodegradable adjuvant Montanide ISA 720/CpG can replace Freund's in a cancer vaccine targeting ED-B-a prerequisite for clinical development

Huijbers, Elisabeth J M; Femel, Julia; Andersson, Karl; Björkelund, Hanna et al.

Ingår i Vaccine, s. 225-230, 2012

• DOI för The non-toxic and biodegradable adjuvant Montanide ISA 720/CpG can replace Freund's in a cancer vaccine targeting ED-B-a prerequisite for clinical development

Extended cleavage specificity of the mast cell chymase from the crab-eating macaque (Macaca fascicularis): an interesting animal model for the analysis of the function of the human mast cell chymase

Thorpe, Michael; Yu, Jing; Boinapally, Vamsi; Ahooghalandari, Parvin et al.

Ingår i International Immunology, s. 771-782, 2012

• DOI för Extended cleavage specificity of the mast cell chymase from the crab-eating macaque (Macaca fascicularis): an interesting animal model for the analysis of the function of the human mast cell chymase

Discriminating between the activities of human cathepsin G and chymase using fluorogenic substrates

Korkmaz, Brice; Jegot, Gwenhael; Lau, Laurie C.; Thorpe, Michael et al.

Ingår i The FEBS Journal, s. 2635-2646, 2011

• DOI för Discriminating between the activities of human cathepsin G and chymase using fluorogenic substrates

Vaccination against the extra domain-B of fibronectin as a novel tumor therapy

Huijbers, Elisabeth J. M.; Ringvall, Maria; Femel, Julia; Kalamajski, Sebastian et al.

Ingår i The FASEB Journal, s. 4535-4544, 2010

• DOI för Vaccination against the extra domain-B of fibronectin as a novel tumor therapy

High degree of conservation of the multigene tryptase locus over the past 150-200 million years of mammalian evolution

Reimer, Jenny; Samollow, Paul; Hellman, Lars

Ingår i Immunogenetics, s. 369-382, 2010

• DOI för High degree of conservation of the multigene tryptase locus over the past 150-200 million years of mammalian evolution

Arg143 and Lys192 of the human mast cell chymase mediate the preference for acidic amino acids in position P2′ of substrates

Andersson, Mattias K.; Thorpe, Michael; Hellman, Lars

Ingår i The FEBS Journal, s. 2255-2267, 2010

• DOI för Arg143 and Lys192 of the human mast cell chymase mediate the preference for acidic amino acids in position P2′ of substrates

Cloning and structural analysis of two highly divergent IgA isotypes, IgA1 and IgA2 from the duck billed platypus, Ornithorhynchus anatinus

Vernersson, Molly; Belov, K.; Aveskogh, Maria; Hellman, Lars

Ingår i Molecular Immunology, s. 785-791, 2010

• DOI för Cloning and structural analysis of two highly divergent IgA isotypes, IgA1 and IgA2 from the duck billed platypus, Ornithorhynchus anatinus

Cloning and structural analysis of two highly divergent IgA isotypes, IgA1 and IgA2 from the duck billed platypus, Ornithorhynchus anatinus

Vernersson, Molly; Belov, K.; Aveskogh, Maria; Hellman, Lars

Ingår i Molecular Immunology, s. 785-791, 2010

• DOI för Cloning and structural analysis of two highly divergent IgA isotypes, IgA1 and IgA2 from the duck billed platypus, Ornithorhynchus anatinus

Lyn Kinase Controls Basophil GATA-3 Transcription Factor Expression and Induction of Th2 Cell Differentiation

Charles, Nicolas; Watford, T; Ramos, L; Hellman, Lars et al.

Ingår i Immunity, s. 533-543, 2009

• DOI för Lyn Kinase Controls Basophil GATA-3 Transcription Factor Expression and Induction of Th2 Cell Differentiation

Identification of potent biodegradable adjuvants that efficiently break self-tolerance: a key issue in the development of therapeutic vaccines

Ringvall, Maria; Huijbers, Elisabeth J. M.; Ahooghalandari, Parvin; Alekseeva, Ludmila et al.

Ingår i Vaccine, s. 48-52, 2009

• DOI för Identification of potent biodegradable adjuvants that efficiently break self-tolerance: a key issue in the development of therapeutic vaccines

The extended substrate cleavage specificity of the human mast cell chymase reveals a serine protease with well-defined substrate recognition profile

Andersson, Mattias K.; Enoksson, Mattias; Gallwitz, Maike; Hellman, Lars

Ingår i International Immunology, s. 95-104, 2009

• DOI för The extended substrate cleavage specificity of the human mast cell chymase reveals a serine protease with well-defined substrate recognition profile

Ornithorhynchus anatinus (Platypus) Links the Evolution of Immunoglobulin Genes in Eutherian Mammals and Nonmammalian Tetrapods

Zhao, Yaofeng; Cui, Huiting; Whittington, Camilla M.; Wei, Zhiguo et al.

Ingår i Journal of Immunology, s. 3285-3293, 2009

• DOI för Ornithorhynchus anatinus (Platypus) Links the Evolution of Immunoglobulin Genes in Eutherian Mammals and Nonmammalian Tetrapods

The extended cleavage specificity of the rodent β-chymases rMCP-1 and mMCP-4 reveal major fumctional similarities to the human mast cell chymase

Andersson, Mattias K.; Karlson, Ulrika; Hellman, Lars

Ingår i Molecular Immunology, s. 766-775, 2008

• DOI för The extended cleavage specificity of the rodent β-chymases rMCP-1 and mMCP-4 reveal major fumctional similarities to the human mast cell chymase

Extended cleavage specificity of mMCP-1, the major mucosal mast cell protease in mouse - High specificity indicates high substrate selectivity

Andersson, Mattias K.; Pemberton, Alan D.; Miller, Hugh R. P.; Hellman, Lars

Ingår i Molecular Immunology, s. 2548-2558, 2008

• DOI för Extended cleavage specificity of mMCP-1, the major mucosal mast cell protease in mouse - High specificity indicates high substrate selectivity

Extended substrate specificity of opossum chymase: Implications for the origin of mast cell chymases

Reimer, Jenny; Enoksson, Mattias; Samollow, Paul; Hellman, Lars

Ingår i Molecular Immunology, s. 2116-2125, 2008

• DOI för Extended substrate specificity of opossum chymase: Implications for the origin of mast cell chymases

High plasma IgE levels within the Scandinavian wolf population, and its implications for mammalian IgE homeostasis

Ledin, Anna; Arnemo, Jon M.; Liberg, Olof; Hellman, Lars

Ingår i Molecular Immunology, s. 1976-1980, 2008

• DOI för High plasma IgE levels within the Scandinavian wolf population, and its implications for mammalian IgE homeostasis

Therapeutic vaccines against IgE-mediated allergies.

Hellman, Lars

Ingår i Expert Rev Vaccines, s. 193-208, 2008

Expression profile of novel members of the rat mast cell protease (rMCP)-2 and (rMCP)-8 families, and functional analyses of mouse mast cell protease (mMCP)-8

Gallwitz, Maike; Enoksson, Mattias; Hellman, Lars

Ingår i Immunogenetics, s. 391-405, 2007

• DOI för Expression profile of novel members of the rat mast cell protease (rMCP)-2 and (rMCP)-8 families, and functional analyses of mouse mast cell protease (mMCP)-8

Serglycin proteoglycan is required for secretory granule integrity in mucosal mast cells

Braga, Tiago; Grujic, Mirjana; Lukinius, Agneta; Hellman, Lars et al.

Ingår i Biochemical Journal, s. 49-57, 2007

• DOI för Serglycin proteoglycan is required for secretory granule integrity in mucosal mast cells

Modifications increasing the efficacy of recombinant vaccines: marked increase in antibody titers with moderately repetitive variants of a therapeutic allergy vaccine

Johansson, Jeannette; Hellman, Lars

Ingår i Vaccine, s. 1676-1682, 2007

• DOI för Modifications increasing the efficacy of recombinant vaccines: marked increase in antibody titers with moderately repetitive variants of a therapeutic allergy vaccine

Generation of therapeutic antibody responses against IgE in dogs, an animal species with exceptionally high plasma IgE levels.

Ledin, Anna; Bergvall, Kerstin; Salmon Hillbertz, Nicolette; Hansson, Helene et al.

Ingår i Vaccine, s. 66-74, 2006

• DOI för Generation of therapeutic antibody responses against IgE in dogs, an animal species with exceptionally high plasma IgE levels.

Expansion of the mast cell chymase locus over the past 200 million years of mammalian evolution

Gallwitz, Maike; Reimer, Jenny; Hellman, Lars

Ingår i Immunogenetics, s. 655-669, 2006

• DOI för Expansion of the mast cell chymase locus over the past 200 million years of mammalian evolution

Isolation of transcriptionally active umbilical cord blood-derived basophils expressing FcεRI, HLA-DR and CD203c

Reimer, Jenny; Magnusson, Sofia; Juremalm, Mikael; Nilsson, Gunnar et al.

Ingår i Allergy. European Journal of Allergy and Clinical Immunology, s. 1063-1070, 2006

• DOI för Isolation of transcriptionally active umbilical cord blood-derived basophils expressing FcεRI, HLA-DR and CD203c

Granzyme-like sequences in bony fish shed light on the emergence of hematopoietic serine proteases during vertebrate evolution

Wernersson, Sara; Reimer, Jenny; Poorafshar, Maryam; Karlson, Ulrika et al.

Ingår i Developmental and Comparative Immunology, s. 901-918, 2006

• DOI för Granzyme-like sequences in bony fish shed light on the emergence of hematopoietic serine proteases during vertebrate evolution

TCR gamma chain diversity in the spleen of the duckbill platypus (Ornithorhynchus anatinus).

Parra, Zuly E.; Arnold, Tamara; Nowak, Melissa A.; Hellman, Lars et al.

Ingår i Developmental and Comparative Immunology, s. 699-710, 2006

Rapid species-specific diversification of the mast cell chymase locus during mammalian evolution.

Gallwitz, Maike; Hellman, Lars

Ingår i Immunogenetics, s. 641-654, 2006

High variability in complementarity-determining regions compensates for a low number of V gene families in the lambda light chain locus of the platypus.

Johansson, Jeannette; Salazar, Janice N; Aveskogh, Maria; Munday, Barry et al.

Ingår i Eur J Immunol, s. 3008-19, 2005

Identification of Adjuvants that Enhance the Therapeutic Antibody Response to Host IgE

Johansson, Jeannette; Ledin, Anna; Vernersson, Molly; Lövgren-Bengtsson, Karin et al.

Ingår i Vaccine, s. 2873-2880, 2004

• DOI för Identification of Adjuvants that Enhance the Therapeutic Antibody Response to Host IgE

The complexity of expressed kappa light chains in egg-laying mammals.

Nowak, Melissa A; Parra, Zuly E; Hellman, Lars; Miller, Robert D

Ingår i Immunogenetics, s. 555-63, 2004

Cloning of IgE from the echidna (Tachyglossus aculeatus) and a comparative analysis of e chains from all three extant mammalian lineages

Vernersson, Molly; Aveskogh, Maria; Hellman, Lars

Ingår i Dev Comp Immunol, s. 61-75, 2004

A novel Krüppel-Associated Box identified in a panel of mammalian zinc finger proteins

Looman, Camilla; Hellman, Lars; Abrink, Magnus

Ingår i Mamm Genome, s. 35-40, 2004

Isolation of monotreme T-cell receptor alpha and beta chains.

Belov, Katherine; Miller, Robert D; Ilijeski, Aron; Hellman, Lars et al.

Ingår i Immunogenetics, s. 164-9, 2004

Platypus IgM and the divergence of the two extant monotreme lineages.

Belov, Katherine; Hellman, Lars

Ingår i Australian Mammology, s. 87-94, 2003

MZF6D, a novel KRAB zinc finger gene expressed exclusively in meiotic male germ cells.

Looman, Camilla; Åbrink, Magnus; Mark, Charlotta; Hellman, Lars

Ingår i DNA and Cell Biology, s. 489-496, 2003

Evolution of the major histocompatibility complex: Isolation of class II _ cDNAs from two monotremes, the platypus and the short-beaked echidna.

Belov, Katherine; Lam, MKP; Hellman, Lars; Colgan, DJ.

Ingår i Immunogenetics, s. 402-411, 2003

Characterization of b2-microglobulin coding sequence from three non-placental mammals; the duck billed platypus, the short beaked echidna, and the grey short-tailed opossum.

Miska, K.B; Hellman, Lars; Miller, Robert D.

Ingår i Developmental and Comparative Immunology, s. 247-256, 2003

MZF6D, a novel KRAB zinc-finger gene expressed exclusively in meiotic male germ cells.

Looman, Camilla; Mark, Charlotta; Abrink, Magnus; Hellman, Lars

Ingår i DNA and Cell Biology, s. 489-96, 2003

Immunoglobulin genetics of Ornithorhynchus anatinus (platypus) and Tachyglossus aculeatus (short-beaked echidna).

Belov, Katherine; Hellman, Lars

Ingår i Comp Biochem Physiol A Mol Integr Physiol, s. 811-9, 2003

Evolution of the major histocompatibility complex: Isolation of class II beta cDNAs from two monotremes, the platypus and the short-beaked echidna.

Belov, Katherine; Lam, Mary K P; Hellman, Lars; Colgan, Donald J

Ingår i Immunogenetics, s. 402-11, 2003

Extended substrate specificity of rat mast cell protease 5, a rodent alpha chymase with elastase-like primary specificity

Karlson, Ulrika; Pejler, Gunnar; Tomasini-Johansson, Bianca; Hellman, Lars

Ingår i Journal of Biological Chemistry, s. 39625-39631, 2003

• DOI för Extended substrate specificity of rat mast cell protease 5, a rodent alpha chymase with elastase-like primary specificity

Characterization of of echidna IgM provides insight into the time of divergence of extant mammals.

Belov, Katherine; Hellman, Lars; Cooper, D.W.

Ingår i Developmental and Comparative Immunology, s. 831-839, 2002

Echidna IgA supports mammalian unity and traditional Therian relationship

Belov, Katherine; Zenger, K.R.; Hellman, Lars; Cooper, D.W.

Ingår i Mammalian Genome, s. 656-663, 2002

Characterization of IgG from a monotreme, Tachyglossus aculeatus

Belov, Katherine; Hellman, Lars; Cooper, D.W.

Ingår i Immunogenetics, s. 1065-1071, 2002

Generation of therapeutic antibody responses against IgE through vaccination

Vernersson, Molly; Ledin, Anna; Johansson, Jeannette; Hellman, Lars

Ingår i The FASEB J:, s. 875-877 + On Line, 2002

Heavy chain V region diversity in the duck-billed platypus (Ornithorhynchus anatinus): Long and highly variable complementarity-determining region 3 compensates for limited germ line diversity.

Johansson, Jeannette; Aveskogh, Maria; Munday, Barry; Hellman, Lars

Ingår i J. Immunol., s. 5155-5162, 2002

Rat mast cell protease 4, a beta chymase with a unusually stringent substrate specificity.

Karlson, Ulrika; Pejler, Gunnar; Fröman, Gunnar; Hellman, Lars

Ingår i J. Biol. Chem., s. 18579-18585, 2002

The major histocompatibility complex in monotremes; an analysis of the evolution of the MHC Class I genes across all three mammalian subclasses.

Miska, K.B; Hellman, Lars; Miller, Robert D.

Ingår i Immunogenetics, s. 381-393, 2002

KRAB zinc finger proteins; an analysis of the molecular mechanisms governing their increase in numbers and complexity during evolution.

Looman, Camilla; Åbrink, Magnus; Mark, Charlotta; Hellman, Lars

Ingår i Molecular Biology and Evolution, s. 2118-2130, 2002

Evidence for an early appearance of modern post switch immunoglobulin isotypes in mammalian evolution (II), cloning of IgE, IgG1 and IgG2 from a monotreme, the duck billed platypus Ornithorhynchus anatinus.

Vernersson, Molly; Aveskogh, Maria; Munday, Barry; Hellman, Lars

Ingår i European Journal of Immunology, s. 2145-2155, 2002

Altered storage of proteases in mast cells from mice lacking heparin: a possible role for heparin in carboxypeptidase A processing.

Henningsson, Frida; Ledin, Johan; Lunderius, Carolina; Wilén, M et al.

Ingår i Biological Chemistry, s. 793-801, 2002

Cloning and structural analysis of IgM (μ chain) and the heavy chain V region repertoire in the marsupial Monodelphis domestica

Aveskogh, Maria; Pilström, Lars; Hellman, Lars

Ingår i Developmental and Comparative Immunology, s. 597-606, 1999

• DOI för Cloning and structural analysis of IgM (μ chain) and the heavy chain V region repertoire in the marsupial Monodelphis domestica

Secretory granule proteases in rat mast cells: Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations

Lützelschwab, Claudia; Pejler, Gunnar; Aveskogh, Maria; Hellman, Lars

Ingår i Journal of Experimental Medicine, s. 13-29, 1997

• DOI för Secretory granule proteases in rat mast cells: Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations

Stem cell factor-dependent human cord blood derived mast cells express alpha- and beta-tryptase, heparin and chondroitin sulphate

Nilsson, G; Blom, T; Harvima, I; Kusche-Gullberg, M et al.

Ingår i Immunology, s. 308-314, 1996

Characterization of a human basophil-like cell line (LAMA-84)

Blom, T; Nilsson, G; Sundström, C; Nilsson, K et al.

Ingår i Scand. J. Immunol., s. 54-61, 1996

A single major transcript encodes the membrane-bound form of rat immunoglobulin E

Aveskogh, Maria; Hellman, Lars

Ingår i Scandinavian Journal of Immunology, s. 535-539, 1995

• DOI för A single major transcript encodes the membrane-bound form of rat immunoglobulin E

Phenotypic characterization of KU812, a cell line identified as an immature human basophilic leukocyte

Blom, Thomas; Huang, Ryanyang; Aveskogh, Maria; Nilsson, Kenneth et al.

Ingår i European Journal of Immunology, s. 2025-2032, 1992

• DOI för Phenotypic characterization of KU812, a cell line identified as an immature human basophilic leukocyte

Cloning and structural analysis of a gene encoding a mouse mastocytoma proteoglycan core protein: Analysis of its evolutionary relation to three cross hybridizing regions in the mouse genome

Angerth, Tomas; Huang, Ranyang; Aveskogh, Maria; Pettersson, Inger et al.

Ingår i Gene, s. 235-240, 1990

• DOI för Cloning and structural analysis of a gene encoding a mouse mastocytoma proteoglycan core protein: Analysis of its evolutionary relation to three cross hybridizing regions in the mouse genome

Mast Cell and Basophil Granule Proteases-In Vivo Targets and Function

Hellman, Lars; Akula, Srinivas; Fu, Zhirong; Wernersson, Sara

Ingår i Frontiers in Immunology, 2022

• DOI för Mast Cell and Basophil Granule Proteases-In Vivo Targets and Function
• Ladda ner fulltext (pdf) av Mast Cell and Basophil Granule Proteases-In Vivo Targets and Function

The Evolutionary History of the Chymase Locus -a Locus Encoding Several of the Major Hematopoietic Serine Proteases

Akula, Srinivas; Fu, Zhirong; Wernersson, Sara; Hellman, Lars

Ingår i International Journal of Molecular Sciences, 2021

• DOI för The Evolutionary History of the Chymase Locus -a Locus Encoding Several of the Major Hematopoietic Serine Proteases
• Ladda ner fulltext (pdf) av The Evolutionary History of the Chymase Locus -a Locus Encoding Several of the Major Hematopoietic Serine Proteases

Tracing the Origins of IgE, Mast Cells, and Allergies by Studies of Wild Animals

Hellman, Lars T.; Akula, Srinivas; Thorpe, Michael; Fu, Zhirong

Ingår i Frontiers in Immunology, 2017

• DOI för Tracing the Origins of IgE, Mast Cells, and Allergies by Studies of Wild Animals
• Ladda ner fulltext (pdf) av Tracing the Origins of IgE, Mast Cells, and Allergies by Studies of Wild Animals

Granule proteases of hematopoietic cells, a family of versatile inflammatory mediators - an update on their cleavage specificity, in vivo substrates, and evolution

Hellman, Lars; Thorpe, Michael

Ingår i Biological chemistry (Print), s. 15-49, 2014

• DOI för Granule proteases of hematopoietic cells, a family of versatile inflammatory mediators - an update on their cleavage specificity, in vivo substrates, and evolution

Therapeutic vaccines against IgE-mediated allergies

Hellman, Lars

Ingår i Expert Review of Vaccines, s. 193-208, 2008

• DOI för Therapeutic vaccines against IgE-mediated allergies

Regulation of IgE homeostasis, and the identification of potential targets for therapeutic intervention

Hellman, Lars

Ingår i Biomedicine and Pharmacotherapy, s. 34-49, 2007

• DOI för Regulation of IgE homeostasis, and the identification of potential targets for therapeutic intervention

The Appearance and Diversification of Receptors for IgM During Vertebrate Evolution

Akula, Srinivas; Hellman, Lars

Ingår i IGM AND ITS RECEPTORS AND BINDING PROTEINS, s. 1-23, SPRINGER-VERLAG BERLIN, 2017

• DOI för The Appearance and Diversification of Receptors for IgM During Vertebrate Evolution

Development of a therapeutic vaccine targeting blood vessels in primary tumors and metastases

Huijbers, Elisabeth JM; Femel, Julia; Cedervall, Jessica; Hein, Tobias et al.

2012

The mouse mast cell transcriptome

Akula, Srinivas; Paivandy, Aida; Thorpe, Michael; Pjeler, Gunnar et al.