Våra aktuella publiceringar

A comprehensive mechanistic investigation of factors affecting intestinal absorption and bioavailability of two PROTACs in rats

Niessen, Janis; Arendt, Nathalie; Sjöblom, Markus; Dubbelboer, Ilse R. et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, 2025

• DOI för A comprehensive mechanistic investigation of factors affecting intestinal absorption and bioavailability of two PROTACs in rats
• Ladda ner fulltext (pdf) av A comprehensive mechanistic investigation of factors affecting intestinal absorption and bioavailability of two PROTACs in rats

A Novel Approach for the Analysis of microDNA and microRNA Using Capillary Zone Electrophoresis

Regnell, Julia

2025

• Ladda ner fulltext (pdf) av A Novel Approach for the Analysis of microDNA and microRNA Using Capillary Zone Electrophoresis

A Practical Approach to Implementing ICH Q14: Tools for Analytical Quality by Design in Capillary Electrophoresis Method Development

Tricht, Ewoud van; Sänger-van de Griend, Cari

Ingår i Electrophoresis, s. 933-953, 2025

• DOI för A Practical Approach to Implementing ICH Q14: Tools for Analytical Quality by Design in Capillary Electrophoresis Method Development
• Ladda ner fulltext (pdf) av A Practical Approach to Implementing ICH Q14: Tools for Analytical Quality by Design in Capillary Electrophoresis Method Development

Canagliflozin: Pharmacokinetics, tolerability and glucose/insulin effects of supratherapeutic doses in healthy horses

Michanek, Peter; Bröjer, Johan; Lilliehöök, Inger; Fjordbakk, Cathrine et al.

Ingår i The Veterinary Journal, 2025

• DOI för Canagliflozin: Pharmacokinetics, tolerability and glucose/insulin effects of supratherapeutic doses in healthy horses
• Ladda ner fulltext (pdf) av Canagliflozin: Pharmacokinetics, tolerability and glucose/insulin effects of supratherapeutic doses in healthy horses

Developing a HPLC-UV and HPLC-MS compatible method for analysis of water-soluble vitamins in plasma solutions.

Keyvani, Arvand

2025

Development of Enhanced Separation Techniques for Oligonucleotides Utilizing Mixed-Mode Chromatography and 2D-LC/UV/MS Analysis

Haglöf, Jakob; Nilsson, Jenny M.; Ludvigsson, Jufang Wu

Ingår i Journal of Separation Science, 2025

• DOI för Development of Enhanced Separation Techniques for Oligonucleotides Utilizing Mixed-Mode Chromatography and 2D-LC/UV/MS Analysis
• Ladda ner fulltext (pdf) av Development of Enhanced Separation Techniques for Oligonucleotides Utilizing Mixed-Mode Chromatography and 2D-LC/UV/MS Analysis

Development of LC-MS method forenantiomeric separation oftriacylglycerols from rat liver tissue: Determination doxorubicin’s effect on TG enantiomercontent in liver

Stephansson, Edvin

2025

• Ladda ner fulltext (pdf) av Development of LC-MS method forenantiomeric separation oftriacylglycerols from rat liver tissue: Determination doxorubicin’s effect on TG enantiomercontent in liver

Gel-free capillary zone electrophoresis at acidic pH for micro DNA and RNA analysis

Haglöf, Jakob; Bivehed, Erik; Sänger-van de Griend, Cari

Ingår i Talanta, 2025

• DOI för Gel-free capillary zone electrophoresis at acidic pH for micro DNA and RNA analysis
• Ladda ner fulltext (pdf) av Gel-free capillary zone electrophoresis at acidic pH for micro DNA and RNA analysis

Improved pharmacotherapy after revised dosing regimens of two slow-release formulations of benzylpenicillin in an Actinobacillus pleuropneumoniae infection model in pigs

Sjolund, Marie; Rosendal, Thomas; Wallgren, Per; Pringle, Maerit et al.

Ingår i Acta Veterinaria Scandinavica, 2025

• DOI för Improved pharmacotherapy after revised dosing regimens of two slow-release formulations of benzylpenicillin in an Actinobacillus pleuropneumoniae infection model in pigs
• Ladda ner fulltext (pdf) av Improved pharmacotherapy after revised dosing regimens of two slow-release formulations of benzylpenicillin in an Actinobacillus pleuropneumoniae infection model in pigs

Mapping the polar metabolome in Huh-7 liver cancer cells reveal the role of atorvastatin in enhancing chemotherapeutic efficacy of doxorubicin.

Kopsida, Maria; Regtop, Lotta; Lennernäs, Hans; Hedeland, Mikael et al.

Ingår i Journal of Pharmaceutical and Biomedical Analysis, s. 117012, 2025

• DOI för Mapping the polar metabolome in Huh-7 liver cancer cells reveal the role of atorvastatin in enhancing chemotherapeutic efficacy of doxorubicin.
• Ladda ner fulltext (pdf) av Mapping the polar metabolome in Huh-7 liver cancer cells reveal the role of atorvastatin in enhancing chemotherapeutic efficacy of doxorubicin.

Metabolic Profiling Reveals a Glycolytic Shift and an IRG1/Itaconate/NF2L2 Axis Regulating Neurotoxic Oxidative Stress in Inflammatory Microglia

Engskog-Vlachos, Pinelopi; Engskog, Mikael K R; Skandik, Martin; Grabert, Kathleen et al.

Ingår i Journal of Neurochemistry, 2025

• DOI för Metabolic Profiling Reveals a Glycolytic Shift and an IRG1/Itaconate/NF2L2 Axis Regulating Neurotoxic Oxidative Stress in Inflammatory Microglia
• Ladda ner fulltext (pdf) av Metabolic Profiling Reveals a Glycolytic Shift and an IRG1/Itaconate/NF2L2 Axis Regulating Neurotoxic Oxidative Stress in Inflammatory Microglia

Method Development and Validation for Beta-Agonists in Liver and Urine using UHPLC-MS/MS, according to EU-Legislation 2021/808

Al Sahli, Maram Samih

2025

• Ladda ner fulltext (pdf) av Method Development and Validation for Beta-Agonists in Liver and Urine using UHPLC-MS/MS, according to EU-Legislation 2021/808

Peak Integration of Electropherograms in GMP and Research Labs: Navigating Increased Scrutiny Amid Data Integrity Audits and Inspections

Blanc, Timothy; Wätzig, Hermann; Sänger-van de Griend, Cari

Ingår i Electrophoresis, s. 653-668, 2025

• DOI för Peak Integration of Electropherograms in GMP and Research Labs: Navigating Increased Scrutiny Amid Data Integrity Audits and Inspections
• Ladda ner fulltext (pdf) av Peak Integration of Electropherograms in GMP and Research Labs: Navigating Increased Scrutiny Amid Data Integrity Audits and Inspections

Personalized Veterinary Tablets for FIP Treatment Using 3D Printing: Development, Content Uniformity, and Stability Testing of GS-441524 with the CuraVet System

Tahhan, Eyad

2025

• Ladda ner fulltext (pdf) av Personalized Veterinary Tablets for FIP Treatment Using 3D Printing: Development, Content Uniformity, and Stability Testing of GS-441524 with the CuraVet System

Pharmacokinetics and Alterations in Glucose and Insulin Levels After a Single Dose of Canagliflozin in Healthy Icelandic Horses

Michanek, Peter; Bröjer, Johan; Lilliehöök, Inger; Fjordbakk, Cathrine T et al.

Ingår i Journal of Veterinary Pharmacology and Therapeutics, s. 41-49, 2025

• DOI för Pharmacokinetics and Alterations in Glucose and Insulin Levels After a Single Dose of Canagliflozin in Healthy Icelandic Horses
• Ladda ner fulltext (pdf) av Pharmacokinetics and Alterations in Glucose and Insulin Levels After a Single Dose of Canagliflozin in Healthy Icelandic Horses

The collateral damage of chemotherapy: A time-dependent view of triacylglycerols in doxorubicin-treated rats

Westerberg, Leo

2025

• Ladda ner fulltext (pdf) av The collateral damage of chemotherapy: A time-dependent view of triacylglycerols in doxorubicin-treated rats

Towards an Analytical Procedure Control Strategy for the Capillary Zone Electrophoresis Method for Monoclonal Antibodies: Alternatives for ε-Aminocaproic Acid and Triethylenetetramine

Baxter, Joanne; Fitton, Lori; Sänger-van de Griend, Cari

Ingår i Electrophoresis, 2025

• DOI för Towards an Analytical Procedure Control Strategy for the Capillary Zone Electrophoresis Method for Monoclonal Antibodies: Alternatives for ε-Aminocaproic Acid and Triethylenetetramine
• Ladda ner fulltext (pdf) av Towards an Analytical Procedure Control Strategy for the Capillary Zone Electrophoresis Method for Monoclonal Antibodies: Alternatives for ε-Aminocaproic Acid and Triethylenetetramine

Development and validation of LC-MS/MS methods for the pharmacokinetic assessment of the PROTACs bavdeglutamide (ARV-110) and vepdegestrant (ARV-471)

Niessen, Janis; Nilsson, Jenny M.; Peters, Karsten; Indulkar, Anura et al.

Ingår i Journal of Pharmaceutical and Biomedical Analysis, 2024

• DOI för Development and validation of LC-MS/MS methods for the pharmacokinetic assessment of the PROTACs bavdeglutamide (ARV-110) and vepdegestrant (ARV-471)
• Ladda ner fulltext (pdf) av Development and validation of LC-MS/MS methods for the pharmacokinetic assessment of the PROTACs bavdeglutamide (ARV-110) and vepdegestrant (ARV-471)

Elevated plasma level of arginine and its metabolites at labor among women with preeclampsia: A prospective cohort study

Akhter, Tansim; Hedeland, Mikael; Bergquist, Jonas; Larsson, Anders et al.

Ingår i American Journal of Hypertension, s. 184-191, 2024

• DOI för Elevated plasma level of arginine and its metabolites at labor among women with preeclampsia: A prospective cohort study
• Ladda ner fulltext (pdf) av Elevated plasma level of arginine and its metabolites at labor among women with preeclampsia: A prospective cohort study

Elevated Plasma Levels of Arginines During Labor Among Women with Spontaneous Preterm Birth: A Prospective Cohort Study

Akhter, Tansim; Hedeland, Mikael; Bergquist, Jonas; Ubhayasekera, Kumari et al.

Ingår i American Journal of Reproductive Immunology, 2024

• DOI för Elevated Plasma Levels of Arginines During Labor Among Women with Spontaneous Preterm Birth: A Prospective Cohort Study
• Ladda ner fulltext (pdf) av Elevated Plasma Levels of Arginines During Labor Among Women with Spontaneous Preterm Birth: A Prospective Cohort Study

Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells

Kopsida, Maria; Clavero, Ada Lerma; Khaled, Jaafar; Balgoma, David et al.

Ingår i Molecular Metabolism, 2024

• DOI för Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells
• Ladda ner fulltext (pdf) av Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells

Metabolite Profiling of Drugs using Mass Spectrometry: Identification of analytical targets for doping control and improvements of the metabolite search process

Nilsson Broberg, Malin

2024

• Ladda ner fulltext (pdf) av Metabolite Profiling of Drugs using Mass Spectrometry: Identification of analytical targets for doping control and improvements of the metabolite search process

Screening of RP-HPLC purification conditions for GLP-1 analogues

Voss, Linn

2024

Text Mining and Computational Chemistry Reveal Trends in Applications of Laser Desorption/Ionization Techniques to Small Molecules

Bergman, Nina P.; Bergquist, Jonas; Hedeland, Mikael; Palmblad, Magnus

Ingår i Journal of the American Society for Mass Spectrometry, s. 2507-2515, 2024

• DOI för Text Mining and Computational Chemistry Reveal Trends in Applications of Laser Desorption/Ionization Techniques to Small Molecules
• Ladda ner fulltext (pdf) av Text Mining and Computational Chemistry Reveal Trends in Applications of Laser Desorption/Ionization Techniques to Small Molecules

A multivariate data analysis approach for the investigation of in vitro derived metabolites of ACP-105 in comparison with human in vivo metabolites

Nilsson Broberg, Malin; Tillgren Ohlsson, Rebecca; Bondesson, Ulf; Pettersson, Curt et al.

Ingår i Journal of chromatography. B, 2023

• DOI för A multivariate data analysis approach for the investigation of in vitro derived metabolites of ACP-105 in comparison with human in vivo metabolites
• Ladda ner fulltext (pdf) av A multivariate data analysis approach for the investigation of in vitro derived metabolites of ACP-105 in comparison with human in vivo metabolites

An interlaboratory capillary zone electrophoresis-UV study of various monoclonal antibodies, instruments, and ε-aminocaproic acid lots

Wiesner, Rebecca; Zagst, Holger; Lan, Wenkui; Bigelow, Stewart et al.

Ingår i Electrophoresis, s. 1247-1257, 2023

• DOI för An interlaboratory capillary zone electrophoresis-UV study of various monoclonal antibodies, instruments, and ε-aminocaproic acid lots
• Ladda ner fulltext (pdf) av An interlaboratory capillary zone electrophoresis-UV study of various monoclonal antibodies, instruments, and ε-aminocaproic acid lots

Combining the targeted and untargeted screening of environmental contaminants reveals associations between PFAS exposure and vitamin D metabolism in human plasma.

Carlsson, Henrik; Sreenivasan, Akshai P.; Erngren, Ida; Larsson, Anders et al.

Ingår i Environmental Science, s. 1116-1130, 2023

• DOI för Combining the targeted and untargeted screening of environmental contaminants reveals associations between PFAS exposure and vitamin D metabolism in human plasma.
• Ladda ner fulltext (pdf) av Combining the targeted and untargeted screening of environmental contaminants reveals associations between PFAS exposure and vitamin D metabolism in human plasma.

DNA integrity under alkaline conditions: An investigation of factors affecting the comet assay

Bivehed, Erik; Hellman, Björn; Fan, Yuting; Haglöf, Jakob et al.

Ingår i Mutation research. Genetic toxicology and environmental mutagenesis, 2023

• DOI för DNA integrity under alkaline conditions: An investigation of factors affecting the comet assay
• Ladda ner fulltext (pdf) av DNA integrity under alkaline conditions: An investigation of factors affecting the comet assay

Enantiomeric Separation of Triacylglycerols from Mouse Liver Tissue using CSP-LC-MS/MS

Landström, Sofia

2023

Equine in vivo metabolite profiling of the selective androgen receptor modulator LGD-3303 for doping control

Nilsson Broberg, Malin; Knych, Heather; Bondesson, Ulf; Pettersson, Curt et al.

Ingår i Journal of Pharmaceutical and Biomedical Analysis, 2023

• DOI för Equine in vivo metabolite profiling of the selective androgen receptor modulator LGD-3303 for doping control
• Ladda ner fulltext (pdf) av Equine in vivo metabolite profiling of the selective androgen receptor modulator LGD-3303 for doping control

Functionalization of cellulose nanofibrils to develop novel ROS-sensitive biomaterials

Palo-Nieto, Carlos; Blasi-Romero, Anna; Sandström, Corine; Balgoma, David et al.

Ingår i Materials Advances, s. 1555-1565, 2023

• DOI för Functionalization of cellulose nanofibrils to develop novel ROS-sensitive biomaterials
• Ladda ner fulltext (pdf) av Functionalization of cellulose nanofibrils to develop novel ROS-sensitive biomaterials

Identification and Structural Elucidation of Cannabinoid Metabolites in Horse Urine Using UHPLC-HRMS

Morén, Agnes

2023

• Ladda ner fulltext (pdf) av Identification and Structural Elucidation of Cannabinoid Metabolites in Horse Urine Using UHPLC-HRMS

Investigation of degradation of toxic substances in fungal cultures by mass spectrometric techniques

Stenholm, Åke

2023

• Ladda ner fulltext (pdf) av Investigation of degradation of toxic substances in fungal cultures by mass spectrometric techniques

Optimization of a Microsome Incubation Method using Design of Experiment and Investigation of Metabolites Derived from GLPG0492 and LY2452473: For Application in Doping Control

Tillgren Ohlsson, Rebecca

2023

• Ladda ner fulltext (pdf) av Optimization of a Microsome Incubation Method using Design of Experiment and Investigation of Metabolites Derived from GLPG0492 and LY2452473: For Application in Doping Control

Plasma levels of arginines at term pregnancy in relation to mode of onset of labor and mode of childbirth

Akhter, Tansim; Hedeland, Mikael; Bergquist, Jonas; Ubhayasekera, Kumari et al.

Ingår i American Journal of Reproductive Immunology, 2023

• DOI för Plasma levels of arginines at term pregnancy in relation to mode of onset of labor and mode of childbirth
• Ladda ner fulltext (pdf) av Plasma levels of arginines at term pregnancy in relation to mode of onset of labor and mode of childbirth

Recent capillary electrophoresis applications for upstream and downstream biopharmaceutical process monitoring

van der Burg, Debbie; Josefsson, Leila; Emmer, Åsa; Sänger–van de Griend, Cari E.

Ingår i TrAC. Trends in analytical chemistry, 2023

• DOI för Recent capillary electrophoresis applications for upstream and downstream biopharmaceutical process monitoring
• Ladda ner fulltext (pdf) av Recent capillary electrophoresis applications for upstream and downstream biopharmaceutical process monitoring

Screening of HETP test conditions and resin storage solutions for HIC

Ronnerfors, Lise-Lotte

2023

• Ladda ner fulltext (pdf) av Screening of HETP test conditions and resin storage solutions for HIC

Strategies for capillary electrophoresis: Method development and validation for pharmaceutical and biological applications-Updated and completely revised edition

Krebs, Finja; Zagst, Holger; Stein, Matthias; Ratih, Ratih et al.

Ingår i Electrophoresis, s. 1279-1341, 2023

• DOI för Strategies for capillary electrophoresis: Method development and validation for pharmaceutical and biological applications-Updated and completely revised edition
• Ladda ner fulltext (pdf) av Strategies for capillary electrophoresis: Method development and validation for pharmaceutical and biological applications-Updated and completely revised edition

Trials and tribulations of statistical significance in biochemistry and omics

Montero, Olimpio; Hedeland, Mikael; Balgoma, David

Ingår i TIBS -Trends in Biochemical Sciences. Regular ed., s. 503-512, 2023

• DOI för Trials and tribulations of statistical significance in biochemistry and omics
• Ladda ner fulltext (pdf) av Trials and tribulations of statistical significance in biochemistry and omics

Ammonia Concentration in the Eluent Influences Fragmentation Pattern of Triacylglycerols in Mass Spectrometry Analysis

Velasco, Marta; Balgoma, David; Montero, Olimpio

Ingår i Metabolites, 2022

• DOI för Ammonia Concentration in the Eluent Influences Fragmentation Pattern of Triacylglycerols in Mass Spectrometry Analysis
• Ladda ner fulltext (pdf) av Ammonia Concentration in the Eluent Influences Fragmentation Pattern of Triacylglycerols in Mass Spectrometry Analysis

Analytical Quality by Design Method Development for Vaccine Characterization

Geurink, Lars

2022

• Ladda ner fulltext (pdf) av Analytical Quality by Design Method Development for Vaccine Characterization

Comprehensive Peak Characterization (CPC) in Untargeted LC-MS Analysis

Pirttilä, Kristian; Balgoma, David; Rainer, Johannes; Pettersson, Curt et al.

Ingår i Metabolites, 2022

• DOI för Comprehensive Peak Characterization (CPC) in Untargeted LC-MS Analysis
• Ladda ner fulltext (pdf) av Comprehensive Peak Characterization (CPC) in Untargeted LC-MS Analysis

Concentration of carprofen in the milk of lactating bitches after cesarean section and during inflammatory conditions

Ferrari, Desiree; Lundgren, Sandra; Holmberg, Johanna; Edner, Anna et al.

Ingår i Theriogenology, s. 59-68, 2022

• DOI för Concentration of carprofen in the milk of lactating bitches after cesarean section and during inflammatory conditions

Developing reactive oxygen species-sensitive cellulose nanofibers for chronic wound care

Palo Nieto, Carlos; Blasi Romero, Anna; Balgoma, David; Hedeland, Mikael et al.

2022

Development and Validation of a Quantitative UHPLC-MS-MS Method for the Determination of Alpha-Chloralose in Feline Blood and Application on Blood Samples Collected from Cats with Symptoms of Alpha-Chloralose Poisoning

Windahl, Ulrika; Lundgren, Sandra; Sprycha, Margareta; Tegner, Cecilia et al.

Ingår i Journal of Analytical Toxicology, s. 651-657, 2022

• DOI för Development and Validation of a Quantitative UHPLC-MS-MS Method for the Determination of Alpha-Chloralose in Feline Blood and Application on Blood Samples Collected from Cats with Symptoms of Alpha-Chloralose Poisoning
• Ladda ner fulltext (pdf) av Development and Validation of a Quantitative UHPLC-MS-MS Method for the Determination of Alpha-Chloralose in Feline Blood and Application on Blood Samples Collected from Cats with Symptoms of Alpha-Chloralose Poisoning

Development of analytical methods for the determination of the small molecule component of complex biological systems

Pirttilä, Kristian

2022

• Ladda ner fulltext (pdf) av Development of analytical methods for the determination of the small molecule component of complex biological systems

Investigation of neomycin biodegradation conditions using ericoid mycorrhizal and white rot fungal species

Stenholm, Åke; Hedeland, Mikael; Pettersson, Curt

Ingår i BMC Biotechnology, 2022

• DOI för Investigation of neomycin biodegradation conditions using ericoid mycorrhizal and white rot fungal species
• Ladda ner fulltext (pdf) av Investigation of neomycin biodegradation conditions using ericoid mycorrhizal and white rot fungal species

Method development for mono- and disaccharides monitoring in cell culture medium by capillary and microchip electrophoresis

van der Burg, Debbie; Josefsson, Leila; Mikkonen, Saara; Chotteau, Veronique et al.

Ingår i Electrophoresis, s. 922-929, 2022

• DOI för Method development for mono- and disaccharides monitoring in cell culture medium by capillary and microchip electrophoresis
• Ladda ner fulltext (pdf) av Method development for mono- and disaccharides monitoring in cell culture medium by capillary and microchip electrophoresis

Neomycin removal using the white rot fungus Trametes versicolor

Stenholm, Åke; Hedeland, Mikael; Pettersson, Curt

Ingår i Journal of Environmental Science and Health. Part A, s. 436-447, 2022

• DOI för Neomycin removal using the white rot fungus Trametes versicolor
• Ladda ner fulltext (pdf) av Neomycin removal using the white rot fungus Trametes versicolor

Oceanographic setting influences the prokaryotic community and metabolome in deep-sea sponges

Steffen, Karin; Indraningrat, Anak Agung Gede; Erngren, Ida; Haglöf, Jakob et al.

Ingår i Scientific Reports, 2022

• DOI för Oceanographic setting influences the prokaryotic community and metabolome in deep-sea sponges
• Ladda ner fulltext (pdf) av Oceanographic setting influences the prokaryotic community and metabolome in deep-sea sponges