Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion

Pagnon de la Vega, María; Syvänen, Stina; Giedraitis, Vilmantas; Hooley, Monique et al.

Ingår i Acta neuropathologica communications, 2024

• DOI för Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion
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Benzylhydroxamic acids as inhibitors of insulin regulated aminopeptidase (IRAP)

Beveridge, Julia; Söderström, Marcus; Prieto-Díaz, Rubén; Gutierrez-de-Teran, Hugo et al.

Ingår i European Journal of Medicinal Chemistry Reports, 2024

• DOI för Benzylhydroxamic acids as inhibitors of insulin regulated aminopeptidase (IRAP)
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Design, Synthesis, and Preclinical Evaluation of Peptide-based Radioligands Targeting PSMA and GRPR in Prostate Cancer

Lundmark, Fanny

2024

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Identification of novel and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries

Akaberi, Dario; Pourghasemi Lati, Monireh; Krambrich, Janina; Berger, Julia et al.

Ingår i Antimicrobial Agents and Chemotherapy, s. 1-18, 2024

• DOI för Identification of novel and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries
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Inhibition of Insulin-Regulated Aminopeptidase by Imidazo[1,5-α]pyridines; Synthesis and Evaluation

Engen, Karin; Lundbäck, Thomas; Yadav, Anubha; Puthiyaparambath, Sharathna et al.

Ingår i International Journal of Molecular Sciences, 2024

• DOI för Inhibition of Insulin-Regulated Aminopeptidase by Imidazo[1,5-α]pyridines; Synthesis and Evaluation
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N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands

Wannberg, Johan; Gising, Johan; Henriksson, Martin; Vo, Duc Duy et al.

Ingår i European Journal of Medicinal Chemistry, 2024

• DOI för N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
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Optimized method for fluorine-18 radiolabeling of Affibody molecules using RESCA

Lechi, Francesco; Eriksson, Jonas; Odell, Luke R.; Wegrzyniak, Olivia et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2024

• DOI för Optimized method for fluorine-18 radiolabeling of Affibody molecules using RESCA
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Reduction of renal activity retention of radiolabeled albumin binding domain-derived affinity proteins using a non-residualizing label strategy compared with a cleavable glycine-leucine-glycine-lysine-linker

Lundmark, Fanny; Vorobyeva, Anzhelika; Liu, Yongsheng; Lindbo, Sarah et al.

Ingår i Molecular Medicine Reports, 2024

• DOI för Reduction of renal activity retention of radiolabeled albumin binding domain-derived affinity proteins using a non-residualizing label strategy compared with a cleavable glycine-leucine-glycine-lysine-linker
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Regional distribution of mechanical strain and macrophage-associated lung inflammation after ventilator-induced lung injury: an experimental study

Liggieri, Francesco; Chiodaroli, Elena; Pellegrini, Mariangela; Puuvuori, Emmi et al.

Ingår i Intensive Care Medicine Experimental, 2024

• DOI för Regional distribution of mechanical strain and macrophage-associated lung inflammation after ventilator-induced lung injury: an experimental study
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Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET

Schlein, Eva; Rokka, Johanna; Odell, Luke R.; Lopes van den Broek, Sara et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2024

• DOI för Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET
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Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET

Schlein, Eva; Rokka, Johanna; Odell, Luke R.; van den Broek, Sara Lopes et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2024

• DOI för Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET

Synthesis of N-Alkenylated Heterocycles via T₃P-Promoted Condensation with Ketones

Balestri, Lorenzo Jacopo Ilic; Beveridge, Julia; Gising, Johan; Odell, Luke R.

Ingår i Journal of Organic Chemistry, s. 11203-11214, 2024

• DOI för Synthesis of N-Alkenylated Heterocycles via T₃P-Promoted Condensation with Ketones
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The decanoate esters of nandrolone, testosterone, and trenbolone induce steroid specific memory impairment and somatic effects in the male rat

Zelleroth, Sofia; Stam, Frida; Nylander, Erik; Ellinor, Kjellgren et al.

Ingår i Hormones and Behavior, 2024

• DOI för The decanoate esters of nandrolone, testosterone, and trenbolone induce steroid specific memory impairment and somatic effects in the male rat
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The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds

Gising, Johan; Honarnejad, Saman; Bras, Maaike; Baillie, Gemma L. et al.

Ingår i International Journal of Molecular Sciences, 2024

• DOI för The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds
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Two Novel [⁶⁸Ga]Ga-Labeled Radiotracers Based on Metabolically Stable [Sar¹¹]RM26 Antagonistic Peptide for Diagnostic Positron Emission Tomography Imaging of GRPR-Positive Prostate Cancer

Kanellopoulos, Panagiotis; Bezverkhniaia, Ekaterina; Abouzayed, Ayman; Rosenström, Ulrika et al.

Ingår i ACS Omega, s. 18608-18616, 2024

• DOI för Two Novel [⁶⁸Ga]Ga-Labeled Radiotracers Based on Metabolically Stable [Sar¹¹]RM26 Antagonistic Peptide for Diagnostic Positron Emission Tomography Imaging of GRPR-Positive Prostate Cancer
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¹⁷⁷Lu-labeled PSMA targeting therapeutic with optimized linker for treatment of disseminated prostate cancer; evaluation of biodistribution and dosimetry

Abouzayed, Ayman; Seitova, Kamila; Lundmark, Fanny; Bodenko, Vitalina et al.

Ingår i Frontiers in Oncology, 2023

• DOI för ¹⁷⁷Lu-labeled PSMA targeting therapeutic with optimized linker for treatment of disseminated prostate cancer; evaluation of biodistribution and dosimetry
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[¹⁸F]MK-7246 for Positron Emission Tomography Imaging of the Beta-Cell Surface Marker GPR44

Cheung, Pierre; Amin, Mohammad A.; Zhang, Bo; Lechi, Francesco et al.

Ingår i Pharmaceutics, 2023

• DOI för [¹⁸F]MK-7246 for Positron Emission Tomography Imaging of the Beta-Cell Surface Marker GPR44
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A Base-Free, Low Temperature Click and Release Reaction for the In Situ Generation of Diazomethane

Schembri, Luke S; Olaniran, Esther; Söderström, Marcus; Skillinghaug, Bobo et al.

Ingår i Advanced Synthesis and Catalysis, s. 1839-1845, 2023

• DOI för A Base-Free, Low Temperature Click and Release Reaction for the In Situ Generation of Diazomethane
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Acute nicotine exposure blocks aromatase in the limbic brain of healthy women: A [11C]cetrozole PET study

Dubol, Manon; Immenschuh, Jana; Jonasson, My; Takahashi, Kayo et al.

Ingår i Comprehensive Psychiatry, 2023

• DOI för Acute nicotine exposure blocks aromatase in the limbic brain of healthy women: A [11C]cetrozole PET study
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Acyl Amidines by Pd-Catalyzed Aminocarbonylation: One-Pot Cyclizations and C-11 Labeling

Rydfjord, Jonas; Roslin, Sara; Roy, Tamal; Abbas, Alaa et al.

Ingår i Journal of Organic Chemistry, s. 5078-5089, 2023

• DOI för Acyl Amidines by Pd-Catalyzed Aminocarbonylation: One-Pot Cyclizations and C-11 Labeling
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First-in-human evaluation of [¹⁸F]CETO: a novel tracer for adrenocortical tumours

Silins, Isabella; Sundin, Anders; Lubberink, Mark; O'Sullivan, Lleah et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 398-409, 2023

• DOI för First-in-human evaluation of [¹⁸F]CETO: a novel tracer for adrenocortical tumours
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In Vivo Visualization and Quantification of Neutrophil Elastase in Lungs of COVID-19 Patients: A First-in-Humans PET Study with ¹¹C-NES

Antoni, Gunnar; Lubberink, Mark; Sörensen, Jens; Lindström, Elin et al.

Ingår i Journal of Nuclear Medicine, s. 145-148, 2023

• DOI för In Vivo Visualization and Quantification of Neutrophil Elastase in Lungs of COVID-19 Patients: A First-in-Humans PET Study with ¹¹C-NES
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On-Tissue Chemical Derivatization for Comprehensive Mapping of Brain Carboxyl and Aldehyde Metabolites by MALDI-MS Imaging

Kaya, Ibrahim; Schembri, Luke S; Nilsson, Anna; Shariatgorji, Reza et al.

Ingår i Journal of the American Society for Mass Spectrometry, s. 836-846, 2023

• DOI för On-Tissue Chemical Derivatization for Comprehensive Mapping of Brain Carboxyl and Aldehyde Metabolites by MALDI-MS Imaging
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Palladium(0)-Catalyzed Spirocyclization and Carbonylation Reactions: Ligands Targeting the Angiotensin II Type 2 Receptor

Lindman, Jens

2023

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PET imaging of neutrophil elastase with ¹¹C-GW457427 in Acute Respiratory Distress Syndrome in pigs

Puuvuori, Emmi; Chiodaroli, Elena; Estrada, Sergio; Cheung, Pierre et al.

Ingår i Journal of Nuclear Medicine, s. 423-429, 2023

• DOI för PET imaging of neutrophil elastase with ¹¹C-GW457427 in Acute Respiratory Distress Syndrome in pigs

Preclinical Characterisation of PSMA/GRPR-Targeting Heterodimer [Ga-68]Ga-BQ7812 for PET Diagnostic Imaging of Prostate Cancer: A Step towards Clinical Translation

Lundmark, Fanny; Abouzayed, Ayman; Rinne, Sara S.; Timofeev, Vasiliy et al.

Ingår i Cancers, 2023

• DOI för Preclinical Characterisation of PSMA/GRPR-Targeting Heterodimer [Ga-68]Ga-BQ7812 for PET Diagnostic Imaging of Prostate Cancer: A Step towards Clinical Translation
• Ladda ner fulltext (pdf) av Preclinical Characterisation of PSMA/GRPR-Targeting Heterodimer [Ga-68]Ga-BQ7812 for PET Diagnostic Imaging of Prostate Cancer: A Step towards Clinical Translation

Preclinical Evaluation of a Novel High-Affinity Radioligand [^99mTc]Tc-BQ0413 Targeting Prostate-Specific Membrane Antigen (PSMA)

Bezverkhniaia, Ekaterina; Kanellopoulos, Panagiotis; Abouzayed, Ayman; Larkina, Mariia et al.

Ingår i International Journal of Molecular Sciences, 2023

• DOI för Preclinical Evaluation of a Novel High-Affinity Radioligand [^99mTc]Tc-BQ0413 Targeting Prostate-Specific Membrane Antigen (PSMA)
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Synthesis of Substituted Indazole Acetic Acids by N-N Bond Forming Reactions

Odell, Luke R.; Skillinghaug, Bobo; Matt, Christof; Wu, Peng et al.

Ingår i European Journal of Organic Chemistry, 2023

• DOI för Synthesis of Substituted Indazole Acetic Acids by N-N Bond Forming Reactions
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The GRPR Antagonist [^99mTc]Tc-maSSS-PEG₂-RM26 towards Phase I Clinical Trial: Kit Preparation, Characterization and Toxicity

Abouzayed, Ayman; Borin, Jesper; Lundmark, Fanny; Rybina, Anastasiya et al.

Ingår i Diagnostics, 2023

• DOI för The GRPR Antagonist [^99mTc]Tc-maSSS-PEG₂-RM26 towards Phase I Clinical Trial: Kit Preparation, Characterization and Toxicity
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Thioacetalation and Multi-Component Thiomethylative Friedel-Crafts Arylation Using BF₃SMe₂

Söderström, Marcus; Matt, Christof; Odell, Luke R.

Ingår i ACS Omega, s. 4320-4330, 2023

• DOI för Thioacetalation and Multi-Component Thiomethylative Friedel-Crafts Arylation Using BF₃SMe₂
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¹¹C-PiB and ¹²⁴I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention

Meier, Silvio R.; Sehlin, Dag; Roshanbin, Sahar; Lim Falk, Victoria et al.

Ingår i Journal of Nuclear Medicine, s. 302-309, 2022

• DOI för ¹¹C-PiB and ¹²⁴I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention
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2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands

Roy, Tamal; Petersen, Nadia N.; Gopalan, Greeshma; Gising, Johan et al.

Ingår i Bioorganic & Medicinal Chemistry, 2022

• DOI för 2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands
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Advancements of nature nanocage protein: preparation, identification and multiple applications of ferritins

Li, Han; Xia, Xiaoyu; Tan, Xiaoyi; Zang, Jiachen et al.

Ingår i Critical reviews in food science and nutrition, s. 7117-7128, 2022

• DOI för Advancements of nature nanocage protein: preparation, identification and multiple applications of ferritins

Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds

Gopalan, Greeshma; Palo-Nieto, Carlos; Petersen, Nadia N.; Hallberg, Mathias et al.

Ingår i Bioorganic & Medicinal Chemistry, 2022

• DOI för Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds
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Chronic cerebral blood flow alterations in traumatic brain injury and sports-related concussions

Vedung, Fredrik; Fahlström, Markus; Wall, Anders; Antoni, Gunnar et al.

Ingår i Brain Injury, s. 948-960, 2022

• DOI för Chronic cerebral blood flow alterations in traumatic brain injury and sports-related concussions
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Design, Synthesis, and Evaluation of Linker-Optimised PSMA-Targeting Radioligands

Lundmark, Fanny; Olanders, Gustav; Rinne, Sara Sophie; Abouzayed, Ayman et al.

Ingår i Pharmaceutics, 2022

• DOI för Design, Synthesis, and Evaluation of Linker-Optimised PSMA-Targeting Radioligands
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E-Cigarette Aerosol Deposition and Disposition of [C-11]Nicotine Using Positron Emission Tomography: A Comparison of Nicotine Uptake in Lungs and Brain Using Two Different Nicotine Formulations

Wall, Anders; Roslin, Sara; Borg, Beatrice; McDermott, Simon et al.

Ingår i Pharmaceuticals, 2022

• DOI för E-Cigarette Aerosol Deposition and Disposition of [C-11]Nicotine Using Positron Emission Tomography: A Comparison of Nicotine Uptake in Lungs and Brain Using Two Different Nicotine Formulations
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Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging

Schlein, Eva; Syvänen, Stina; Rokka, Johanna; Gustavsson, Tobias et al.

Ingår i Molecular Pharmaceutics, s. 4111-4122, 2022

• DOI för Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging
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Glucagonlike Peptide-1 Receptor Imaging in Individuals with Type 2 Diabetes

Eriksson, Olof; Velikyan, Irina; Haack, Torsten; Bossart, Martin et al.

Ingår i Journal of Nuclear Medicine, s. 794-800, 2022

• DOI för Glucagonlike Peptide-1 Receptor Imaging in Individuals with Type 2 Diabetes

P-119 - Efficient cartridge-based synthesis of a novel [18F]tetrazine for large molecule labelling

Rokka, Johanna; Syvaenen, Stina; Odell, Luke R.; Schlein, Eva et al.

Ingår i Nuclear Medicine and Biology, 2022

• DOI för P-119 - Efficient cartridge-based synthesis of a novel [18F]tetrazine for large molecule labelling

Palladium-Mediated Synthesis of [Carbonyl-11C]acyl Amidines from Aryl Iodides and Aryl Bromides and Their One-Pot Cyclization to 11C-Labeled Oxadiazoles

Rydfjord, Jonas; Al-Bazaz, Silav; Roslin, Sara

Ingår i Journal of Organic Chemistry, s. 5118-5126, 2022

• DOI för Palladium-Mediated Synthesis of [Carbonyl-11C]acyl Amidines from Aryl Iodides and Aryl Bromides and Their One-Pot Cyclization to 11C-Labeled Oxadiazoles
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PET Imaging in Preclinical Anti-Aβ Drug Development

Syvänen, Stina; Meier, Silvio R.; Roshanbin, Sahar; Xiong, Mengfei et al.

Ingår i Pharmaceutical research, s. 1481-1496, 2022

• DOI för PET Imaging in Preclinical Anti-Aβ Drug Development
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Pharmacodynamic evaluation and safety assessment of treatment with antibodies to serum amyloid P component in patients with cardiac amyloidosis: an open-label Phase 2 study and an adjunctive immuno-PET imaging study

Wechalekar, Ashutosh; Antoni, Gunnar; Al Azzam, Wasfi; Bergstrom, Mats et al.

Ingår i BMC Cardiovascular Disorders, 2022

• DOI för Pharmacodynamic evaluation and safety assessment of treatment with antibodies to serum amyloid P component in patients with cardiac amyloidosis: an open-label Phase 2 study and an adjunctive immuno-PET imaging study
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Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Bonagas, Nadilly; Gustafsson, Nina M. S.; Henriksson, Martin; Marttila, Petra et al.

Ingår i NATURE CANCER, s. 156, 2022

• DOI för Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
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Preclinical evaluation of [C-11]GW457427 as a tracer for neutrophil elastase

Estrada, Sergio; Elgland, Mathias; Selvaraju, Ram Kumar; Mani, Kevin et al.

Ingår i Nuclear Medicine and Biology, s. 62-71, 2022

• DOI för Preclinical evaluation of [C-11]GW457427 as a tracer for neutrophil elastase
• Ladda ner fulltext (pdf) av Preclinical evaluation of [C-11]GW457427 as a tracer for neutrophil elastase

Prodrugs of the Archetypal Dynamin Inhibitor Bis-T-22

Odell, Luke R.; Robertson, Mark J.; Young, Kelly A.; McGeachie, Andrew B. et al.

Ingår i ChemMedChem, 2022

• DOI för Prodrugs of the Archetypal Dynamin Inhibitor Bis-T-22
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Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody

Roshanbin, Sahar; Julku, Ulrika; Xiong, Mengfei; Eriksson, Jonas et al.

Ingår i Pharmaceutics, 2022

• DOI för Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody
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Region-Specific and Age-Dependent Multitarget Effects of Acetylcholinesterase Inhibitor Tacrine on Comprehensive Neurotransmitter Systems

Fridjonsdottir, Elva; Vallianatou, Theodosia; Mantas, Ioannis; Shariatgorji, Reza et al.

Ingår i ACS Chemical Biology, s. 147-158, 2022

• DOI för Region-Specific and Age-Dependent Multitarget Effects of Acetylcholinesterase Inhibitor Tacrine on Comprehensive Neurotransmitter Systems
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Serotonin and dopamine transporter availability in social anxiety disorder after combined treatment with escitalopram and cognitive-behavioral therapy

Hjorth, Olof; Frick, Andreas; Gingnell, Malin; Engman, Jonas et al.

Ingår i Translational Psychiatry, 2022

• DOI för Serotonin and dopamine transporter availability in social anxiety disorder after combined treatment with escitalopram and cognitive-behavioral therapy
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Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)

Lu, Lu; Åkerbladh, Linda; Ahmad, Shabbir; Konda, Vivek et al.

Ingår i ACS - Infectious Diseases, s. 482-498, 2022

• DOI för Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)
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