Sebastian Barg

RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function

Ibrahim, Hazem; Balboa, Diego; Saarimäki-Vire, Jonna; Montaser, Hossam et al.

Ingår i Diabetologia, s. 1642-1662, 2024

• DOI för RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function
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SEC14-like condensate phase transitions at plasma membranes regulate root growth in Arabidopsis

Liu, Chen; Mentzelopoulou, Andriani; Papagavriil, Fotini; Ramachandran, Prashanth et al.

Ingår i PLoS biology, 2023

• DOI för SEC14-like condensate phase transitions at plasma membranes regulate root growth in Arabidopsis
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Local PI(4,5)P₂ signaling inhibits fusion pore expansion during exocytosis

Omar-Hmeadi, Muhmmad; Gucek, Alenka; Barg, Sebastian

Ingår i Cell Reports, 2023

• DOI för Local PI(4,5)P₂ signaling inhibits fusion pore expansion during exocytosis
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The β-cell primary cilium is an autonomous Ca²⁺ compartment for paracrine GABA signaling

Sanchez, Gonzalo; Incedal, Tugce Ceren; Prada, Juan; O'Callaghan, Paul et al.

Ingår i Journal of Cell Biology, 2023

• DOI för The β-cell primary cilium is an autonomous Ca²⁺ compartment for paracrine GABA signaling
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Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction

Yeh, Yu-Te; Sona, Chandan; Yan, Xin; Li, Yunxiao et al.

Ingår i Nature Communications, 2023

• DOI för Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction
• Ladda ner fulltext (pdf) av Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction

Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.

Balboa, Diego; Barsby, Tom; Lithovius, Väinö; Saarimäki-Vire, Jonna et al.

Ingår i Nature Biotechnology, s. 1042-1055, 2022

• DOI för Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.
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Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets

Golec, Ewelina; Ekstrom, Alexander; Noga, Maciej; Omar-Hmeadi, Muhmmad et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2022

• DOI för Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets
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In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis

Petrenko, Volodymyr; Gandasi, Nikhil; Sage, Daniel; Tengholm, Anders et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 2484-2495, 2020

• DOI för In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis
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Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.

Omar-Hmeadi, Muhmmad; Lund, Per-Eric; Gandasi, Nikhil; Tengholm, Anders et al.

Ingår i Nature Communications, 2020

• DOI för Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.
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The Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 is Essential for Proinsulin Handling

Mojtaba Ghiasi, Seyed; Dahlby, Tina; Hede Andersen, Caroline; Haataja, Leena et al.

Ingår i Diabetes, s. 747-760, 2019

• DOI för The Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 is Essential for Proinsulin Handling

Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis

Gucek, Alenka; Gandasi, Nikhil R; Omar-Hmeadi, Muhmmad; Bakke, Marit et al.

Ingår i eLIFE, 2019

• DOI för Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis
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Glucose-Dependent Granule Docking Limits Insulin Secretion and Is Decreased in Human Type 2 Diabetes

Gandasi, Nikhil R; Yin, Peng; Omar-Hmeadi, Muhmmad; Ottosson Laakso, Emilia et al.

Ingår i Cell Metabolism, s. 470-478, 2018

• DOI för Glucose-Dependent Granule Docking Limits Insulin Secretion and Is Decreased in Human Type 2 Diabetes

PtdIns(4,5)P₂ is not required for secretory granule docking

Omar-Hmeadi, Muhmmad; Gandasi, Nikhil R; Barg, Sebastian

Ingår i Traffic, s. 436-445, 2018

• DOI för PtdIns(4,5)P₂ is not required for secretory granule docking

Functional Characterization of Native, High-Affinity GABA_A Receptors in Human Pancreatic β Cells

Korol, Sergiy V; Jin, Zhe; Jin, Yang; Bhandage, Amol K. et al.

Ingår i EBioMedicine, 2018

• DOI för Functional Characterization of Native, High-Affinity GABA_A Receptors in Human Pancreatic β Cells
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Syntaxin clusters at secretory granules in a munc18-bound conformation

Yin, Peng; Gandasi, Nikhil R.; Arora, Swati; Omar-Hmeadi, Muhmmad et al.

Ingår i Molecular Biology of the Cell, s. 2700-2708, 2018

• DOI för Syntaxin clusters at secretory granules in a munc18-bound conformation
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MiR-335 overexpression impairs insulin secretion through defective priming of insulin vesicles

Salunkhe, Vishal A.; Ofori, Jones K.; Gandasi, Nikhil R; Salo, Sofia A. et al.

Ingår i Physiological Reports, 2017

• DOI för MiR-335 overexpression impairs insulin secretion through defective priming of insulin vesicles
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Ca²⁺ channel clustering with insulin-containing granules is disturbed in type 2 diabetes

Gandasi, Nikhil R.; Yin, Peng; Riz, Michela; Chibalina, Margarita V et al.

Ingår i Journal of Clinical Investigation, s. 2353-2364, 2017

• DOI för Ca²⁺ channel clustering with insulin-containing granules is disturbed in type 2 diabetes
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Plasma membrane PI(4,5)P-2 is critical for secretory granule exocytosis

Omar-Hmeadi, Muhmmad; Gandasi, Nikhil R.; Barg, Sebastian

Ingår i Molecular Biology of the Cell, s. 3727-3727, 2017

• DOI för Plasma membrane PI(4,5)P-2 is critical for secretory granule exocytosis

Recruitment of Epac2A to Insulin Granule Docking Sites Regulates Priming for Exocytosis

Alenkvist, Ida; Gandasi, Nikhil R; Barg, Sebastian; Tengholm, Anders

Ingår i Diabetes, s. 2610-2622, 2017

• DOI för Recruitment of Epac2A to Insulin Granule Docking Sites Regulates Priming for Exocytosis

How Kiss-and-Run Can Make Us Sick: SOX4 Puts a Break on the Pore

Barg, Sebastian; Gucek, Alenka

Ingår i Diabetes, s. 1791-1793, 2016

• DOI för How Kiss-and-Run Can Make Us Sick: SOX4 Puts a Break on the Pore

Plasma Membrane Phosphatidylinositol 4,5-Bisphosphate Regulates Ca2+-Influx and Insulin Secretion from Pancreatic beta Cells

Xie, Beichen; Nguyen, Phuoc My; Gucek, Alenka; Thonig, Antje et al.

Ingår i CELL CHEMICAL BIOLOGY, s. 816-826, 2016

• DOI för Plasma Membrane Phosphatidylinositol 4,5-Bisphosphate Regulates Ca2+-Influx and Insulin Secretion from Pancreatic beta Cells

Statistical Frailty Modeling for Quantitative Analysis of Exocytotic Events Recorded by Live Cell Imaging: Rapid Release of Insulin-Containing Granules Is Impaired in Human Diabetic beta-cells

Cortese, Giuliana; Gandasi, Nikhil R.; Barg, Sebastian; Pedersen, Morten Gram

Ingår i PLOS ONE, 2016

• DOI för Statistical Frailty Modeling for Quantitative Analysis of Exocytotic Events Recorded by Live Cell Imaging: Rapid Release of Insulin-Containing Granules Is Impaired in Human Diabetic beta-cells
• Ladda ner fulltext (pdf) av Statistical Frailty Modeling for Quantitative Analysis of Exocytotic Events Recorded by Live Cell Imaging: Rapid Release of Insulin-Containing Granules Is Impaired in Human Diabetic beta-cells

Quantitative Imaging of the Exocytosis Machinery Assembly

Gandasi, Nikhil R.; Barg, Sebastian

Ingår i Biophysical Journal, 2015

MiR-335 regulates exocytotic proteins and affects glucose-stimulated insulin secretion through decreased Ca2+-dependent exocytosis in beta cells

Salunkhe, V. A.; Ofori, J.; Gandasi, Nikhil R.; Salo, S. A. et al.

Ingår i Diabetologia, 2015

G-protein coupled receptor dynamics in insulin secreting cells

Kay, Emma I.; Barg, Sebastian

Ingår i Diabetologia, 2015

Survey of Red Fluorescence Proteins as Markers for Secretory Granule Exocytosis

Gandasi, Nikhil R.; Vesto, Kim; Helou, Maria; Yin, Peng et al.

Ingår i PLOS ONE, 2015

• DOI för Survey of Red Fluorescence Proteins as Markers for Secretory Granule Exocytosis
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The Complement Inhibitor CD59 Regulates Insulin Secretion by Modulating Exocytotic Events

Krus, Ulrika; King, Ben C; Nagaraj, Vini; Gandasi, Nikhil R et al.

Ingår i Cell Metabolism, s. 883-890, 2014

• DOI för The Complement Inhibitor CD59 Regulates Insulin Secretion by Modulating Exocytotic Events

CD59 is required for pancreatic beta cell insulin exocytosis

Krus, Ulrika; King, Benjamin C.; Nagaraj, Vini; Gandasi, Nikhil et al.

Ingår i Molecular Immunology, s. 279-279, 2014

Contact-induced clustering of syntaxin and munc18 docks secretory granules at the exocytosis site

Gandasi, Nikhil R; Barg, Sebastian

Ingår i Nature Communications, 2014

• DOI för Contact-induced clustering of syntaxin and munc18 docks secretory granules at the exocytosis site

Aberrant association between vascular endothelial growth factor receptor-2 and VE-cadherin in response to vascular endothelial growth factor-a in Shb-deficient lung endothelial cells

Zang, Guangxiang; Christoffersson, Gustaf; Tian, Geng; Harun-Or-Rashid, Mohammad et al.

Ingår i Cellular Signalling, s. 85-92, 2013

• DOI för Aberrant association between vascular endothelial growth factor receptor-2 and VE-cadherin in response to vascular endothelial growth factor-a in Shb-deficient lung endothelial cells
• Ladda ner fulltext (pdf) av Aberrant association between vascular endothelial growth factor receptor-2 and VE-cadherin in response to vascular endothelial growth factor-a in Shb-deficient lung endothelial cells

In Intact Islets Interstitial GABA Activates GABA(A) Receptors That Generate Tonic Currents in alpha-Cells

Jin, Yang; Korol, Sergiy V; Jin, Zhe; Barg, Sebastian et al.

Ingår i PLOS ONE, 2013

• DOI för In Intact Islets Interstitial GABA Activates GABA(A) Receptors That Generate Tonic Currents in alpha-Cells
• Ladda ner fulltext (pdf) av In Intact Islets Interstitial GABA Activates GABA(A) Receptors That Generate Tonic Currents in alpha-Cells

PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice

Iglesias, José; Barg, Sebastian; Vallois, David; Lahiri, Shawon et al.

Ingår i Journal of Clinical Investigation, s. 4105-4117, 2012

• DOI för PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice

Multivesicular exocytosis in rat pancreatic beta cells

Hoppa, M B; Jones, E; Karanauskaite, J; Ramracheya, R et al.

Ingår i Diabetologia, s. 1001-1012, 2012

• DOI för Multivesicular exocytosis in rat pancreatic beta cells

Single secretory granules of live cells recruit syntaxin-1 and synaptosomal associated protein 25 (SNAP-25) in large copy numbers

Knowles, M. K.; Barg, Sebastian; Wan, L.; Midorikawa, M. et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 20810-20815, 2010

• DOI för Single secretory granules of live cells recruit syntaxin-1 and synaptosomal associated protein 25 (SNAP-25) in large copy numbers

Syntaxin clusters assemble reversibly at sites of secretory granules in live cells

Barg, Sebastian; Knowles, M. K.; Chen, X.; Midorikawa, M. et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 20804-20809, 2010

• DOI för Syntaxin clusters assemble reversibly at sites of secretory granules in live cells

Defective secretion of islet hormones in chromogranin-B deficient mice

Obermüller, Stefanie; Calegari, Federico; King, Angus; Lindqvist, Anders et al.

Ingår i PLOS ONE, 2010

• DOI för Defective secretion of islet hormones in chromogranin-B deficient mice

Quantitative analysis of t-SNARE and Ca2+-channel clusters near secretory granules

Barg, Sebastian; Gandasi, Nikhil

Ingår i Diabetologia, 2010

• DOI för Quantitative analysis of t-SNARE and Ca2+-channel clusters near secretory granules

cAMP Mediators of Pulsatile Insulin Secretion from Glucose-stimulated Single β-Cells

Idevall Hagren, Olof; Barg, Sebastian; Gylfe, Erik; Tengholm, Anders

Ingår i Journal of Biological Chemistry, s. 23005-23016, 2010

• DOI för cAMP Mediators of Pulsatile Insulin Secretion from Glucose-stimulated Single β-Cells

TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells

da Silva Xavier, Gabriela; Loder, Merewyn K; McDonald, Angela; Tarasov, Andrei I et al.

Ingår i Diabetes, s. 894-905, 2009

• DOI för TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells

High extracellular glucose inhibits exocytosis through disruption of syntaxin 1A-containing lipid rafts

Somanath, Sangeeta; Barg, Sebastian; Marshall, Catriona; Silwood, Christopher J et al.

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 241-246, 2009

• DOI för High extracellular glucose inhibits exocytosis through disruption of syntaxin 1A-containing lipid rafts

Impaired glucose homeostasis in Shb-/- mice

Åkerblom, Björn; Barg, Sebastian; Calounova, Gabriela; Mokhtari, Dariush et al.

Ingår i Journal of Endocrinology, s. 271-279, 2009

• DOI för Impaired glucose homeostasis in Shb-/- mice

Compensatory endocytosis in chromaffin cells

Barg, Sebastian; Machado, Jose David

Ingår i Acta Physiologica, s. 195-201, 2008

• DOI för Compensatory endocytosis in chromaffin cells

Release of the styryl dyes from single synaptic vesicles in hippocampal neurons.

Chen, Xi; Barg, Sebastian; Almers, Wolfhard

Ingår i The Journal of neuroscience : the official journal of the Society for Neuroscience, s. 1894-1903, 2008

• DOI för Release of the styryl dyes from single synaptic vesicles in hippocampal neurons.
• Ladda ner fulltext (pdf) av Release of the styryl dyes from single synaptic vesicles in hippocampal neurons.

Granule docking and cargo release in pancreatic β-cells

Barg, Sebastian; Lindqvist, Anders; Obermüller, Stefanie

Ingår i Biochemical Society Transactions, s. 294-299, 2008

• DOI för Granule docking and cargo release in pancreatic β-cells

Selective nucleotide-release from dense-core granules in insulin-secreting cells

Obermüller, Stefanie; Lindqvist, Anders; Karanauskaite, Jovita; Galvanovskis, Juris et al.

Ingår i Journal of Cell Science, s. 4271-82, 2005

• DOI för Selective nucleotide-release from dense-core granules in insulin-secreting cells
• Ladda ner fulltext (pdf) av Selective nucleotide-release from dense-core granules in insulin-secreting cells

Membrane phosphoinositides control insulin secretion through their effects on ATP-sensitive K+ channel activity.

Lin, Chia-Wei; Yan, Feifei; Shimamura, Satoko; Barg, Sebastian et al.

Ingår i Diabetes, s. 2852-8, 2005

Large dense-core vesicle exocytosis in pancreatic beta-cells monitored by capacitance measurements.

Kanno, Takahiro; Ma, Xiasong; Barg, Sebastian; Eliasson, Lena et al.

Ingår i Methods, s. 302-11, 2004

• DOI för Large dense-core vesicle exocytosis in pancreatic beta-cells monitored by capacitance measurements.

Insulin secretion: a high-affinity Ca2+ sensor after all?

Barg, Sebastian; Rorsman, Patrik

Ingår i The Journal of General Physiology, s. 623-5, 2004

• DOI för Insulin secretion: a high-affinity Ca2+ sensor after all?

SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells.

Eliasson, Lena; Ma, Xiaosong; Renström, Erik; Barg, Sebastian et al.

Ingår i The Journal of General Physiology, s. 181-97, 2003

Mechanisms of exocytosis in insulin-secreting B-cells and glucagon-secreting A-cells.

Barg, Sebastian

Ingår i Pharmacology and Toxicology, s. 3-13, 2003