Per-Eric Lund

3-Oxoisoindoline-1-carboxamides: Potent, State-Dependent Blockers of Voltage-Gated Sodium Channel Na(V)1.7 with Efficacy in Rat Pain Models

Macsari, Istvan; Besidski, Yeygeni; Csjernyik, Gabor; Nilsson, Linda I. et al.

Ingår i Journal of Medicinal Chemistry, s. 6866-6880, 2012

• DOI för 3-Oxoisoindoline-1-carboxamides: Potent, State-Dependent Blockers of Voltage-Gated Sodium Channel Na(V)1.7 with Efficacy in Rat Pain Models

Phenyl isoxazole voltage-gated sodium channel blockers: structure and activity relationship

Macsari, Istvan; Sandberg, Lars; Besidski, Yevgeni; Gravenfors, Ylva et al.

Ingår i Bioorganic & Medicinal Chemistry Letters, s. 3871-3876, 2011

• DOI för Phenyl isoxazole voltage-gated sodium channel blockers: structure and activity relationship

Ryanodine receptor-operated activation of TRP-like channels can trigger critical Ca2+ signaling events in pancreatic beta-cells

Gustafsson, Amanda Jabin; Ingelman-Sundberg, Hanna; Dzabic, Mensur; Awasum, Justina et al.

Ingår i The FASEB Journal, s. 301-303, 2005

• DOI för Ryanodine receptor-operated activation of TRP-like channels can trigger critical Ca2+ signaling events in pancreatic beta-cells

The orexin OX(1) receptor activates a novel Ca2+ influx pathway necessary for coupling to phospholipase C*

Lund, Per-Eric; Shariatmadari, Ramin; Uustare, Ain; Detheux, M et al.

Ingår i J Biol Chem, s. 30806, 2000

Endogenous extracellular purine nucleotides redirect alpha2-adrenoceptor signaling

Akerman, Karl E. O.; Nasman, Johnny; Lund, Per-Eric; Shariatmadari, Ramin et al.

Ingår i FEBS Lett., s. 209, 1998

RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function

Ibrahim, Hazem; Balboa, Diego; Saarimäki-Vire, Jonna; Montaser, Hossam et al.

Ingår i Diabetologia, s. 1642-1662, 2024

• DOI för RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function
• Ladda ner fulltext (pdf) av RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function

Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets

Golec, Ewelina; Ekstrom, Alexander; Noga, Maciej; Omar-Hmeadi, Muhmmad et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2022

• DOI för Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets
• Ladda ner fulltext (pdf) av Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets

Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.

Balboa, Diego; Barsby, Tom; Lithovius, Väinö; Saarimäki-Vire, Jonna et al.

Ingår i Nature Biotechnology, s. 1042-1055, 2022

• DOI för Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.
• Ladda ner fulltext (pdf) av Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.

Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.

Omar-Hmeadi, Muhmmad; Lund, Per-Eric; Gandasi, Nikhil; Tengholm, Anders et al.

Ingår i Nature Communications, 2020

• DOI för Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.
• Ladda ner fulltext (pdf) av Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.

Ca²⁺ channel clustering with insulin-containing granules is disturbed in type 2 diabetes

Gandasi, Nikhil R.; Yin, Peng; Riz, Michela; Chibalina, Margarita V et al.

Ingår i Journal of Clinical Investigation, s. 2353-2364, 2017

• DOI för Ca²⁺ channel clustering with insulin-containing granules is disturbed in type 2 diabetes
• Ladda ner fulltext (pdf) av Ca²⁺ channel clustering with insulin-containing granules is disturbed in type 2 diabetes

RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function

Ibrahim, Hazem; Balboa, Diego; Saarimäki-Vire, Jonna; Montaser, Hossam et al.

Ingår i Diabetologia, s. 1642-1662, 2024

• DOI för RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function
• Ladda ner fulltext (pdf) av RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function

Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets

Golec, Ewelina; Ekstrom, Alexander; Noga, Maciej; Omar-Hmeadi, Muhmmad et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2022

• DOI för Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets
• Ladda ner fulltext (pdf) av Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets

Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.

Balboa, Diego; Barsby, Tom; Lithovius, Väinö; Saarimäki-Vire, Jonna et al.

Ingår i Nature Biotechnology, s. 1042-1055, 2022

• DOI för Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.
• Ladda ner fulltext (pdf) av Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.

Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.

Omar-Hmeadi, Muhmmad; Lund, Per-Eric; Gandasi, Nikhil; Tengholm, Anders et al.

Ingår i Nature Communications, 2020

• DOI för Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.
• Ladda ner fulltext (pdf) av Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.

Ca²⁺ channel clustering with insulin-containing granules is disturbed in type 2 diabetes

Gandasi, Nikhil R.; Yin, Peng; Riz, Michela; Chibalina, Margarita V et al.

Ingår i Journal of Clinical Investigation, s. 2353-2364, 2017

• DOI för Ca²⁺ channel clustering with insulin-containing granules is disturbed in type 2 diabetes
• Ladda ner fulltext (pdf) av Ca²⁺ channel clustering with insulin-containing granules is disturbed in type 2 diabetes

3-Oxoisoindoline-1-carboxamides: Potent, State-Dependent Blockers of Voltage-Gated Sodium Channel Na(V)1.7 with Efficacy in Rat Pain Models

Macsari, Istvan; Besidski, Yeygeni; Csjernyik, Gabor; Nilsson, Linda I. et al.

Ingår i Journal of Medicinal Chemistry, s. 6866-6880, 2012

• DOI för 3-Oxoisoindoline-1-carboxamides: Potent, State-Dependent Blockers of Voltage-Gated Sodium Channel Na(V)1.7 with Efficacy in Rat Pain Models

Phenyl isoxazole voltage-gated sodium channel blockers: structure and activity relationship

Macsari, Istvan; Sandberg, Lars; Besidski, Yevgeni; Gravenfors, Ylva et al.

Ingår i Bioorganic & Medicinal Chemistry Letters, s. 3871-3876, 2011

• DOI för Phenyl isoxazole voltage-gated sodium channel blockers: structure and activity relationship

Ryanodine receptor-operated activation of TRP-like channels can trigger critical Ca2+ signaling events in pancreatic beta-cells

Gustafsson, Amanda Jabin; Ingelman-Sundberg, Hanna; Dzabic, Mensur; Awasum, Justina et al.

Ingår i The FASEB Journal, s. 301-303, 2005

• DOI för Ryanodine receptor-operated activation of TRP-like channels can trigger critical Ca2+ signaling events in pancreatic beta-cells

Intracellular calcium dependence of large dense-core vesicle exocytosis in the absence of synaptotagmin I.

Voets, T; Moser, T; Lund, P E; Chow, R H et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 11680-5, 2001

• DOI för Intracellular calcium dependence of large dense-core vesicle exocytosis in the absence of synaptotagmin I.

The orexin OX1 receptor activates a novel Ca2+ influx pathway necessary for coupling to phospholipase C.

Lund, P E; Shariatmadari, R; Uustare, A; Detheux, M et al.

Ingår i Journal of Biological Chemistry, s. 30806-12, 2000

• DOI för The orexin OX1 receptor activates a novel Ca2+ influx pathway necessary for coupling to phospholipase C.

The orexin OX(1) receptor activates a novel Ca2+ influx pathway necessary for coupling to phospholipase C*

Lund, Per-Eric; Shariatmadari, Ramin; Uustare, Ain; Detheux, M et al.

Ingår i J Biol Chem, s. 30806, 2000

Endogenous extracellular purine nucleotides redirect alpha2-adrenoceptor signaling

Akerman, Karl E. O.; Nasman, Johnny; Lund, Per-Eric; Shariatmadari, Ramin et al.

Ingår i FEBS Lett., s. 209, 1998

Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue.

Garcia-Guzman, M; Soto, F; Gomez-Hernandez, J M; Lund, P E et al.

Ingår i Molecular Pharmacology, s. 109-18, 1997

Stimulation of insulin release by isosmolar addition of permeant molecules.

Lund, P E; Berts, A; Hellman, B

Ingår i Molecular and Cellular Biochemistry, s. 77-81, 1992

Activation of G-proteins induces Ca2+ oscillations with hyperpolarizing K+ currents in pancreatic beta-cells.

Lund, P E; Hellman, B

Ingår i Second messengers and phosphoproteins, s. 173-83, 1991

Leucine induces initial lowering of cytoplasmic Ca2+ in pancreatic beta-cells without concomitant inhibition of insulin release.

Lund, P E; Gylfe, E; Hellman, B

Ingår i Biochemistry international, s. 83-7, 1989

Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes

Omar-Hmeadi, Muhmmad; Lund, Per-Eric; Gandasi, Nikhil; Tengholm, Anders et al.