Omar Hmeadi

RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function

Ibrahim, Hazem; Balboa, Diego; Saarimäki-Vire, Jonna; Montaser, Hossam et al.

Ingår i Diabetologia, s. 1642-1662, 2024

• DOI för RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function
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Local PI(4,5)P₂ signaling inhibits fusion pore expansion during exocytosis

Omar-Hmeadi, Muhmmad; Gucek, Alenka; Barg, Sebastian

Ingår i Cell Reports, 2023

• DOI för Local PI(4,5)P₂ signaling inhibits fusion pore expansion during exocytosis
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Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets

Golec, Ewelina; Ekstrom, Alexander; Noga, Maciej; Omar-Hmeadi, Muhmmad et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2022

• DOI för Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets
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Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.

Balboa, Diego; Barsby, Tom; Lithovius, Väinö; Saarimäki-Vire, Jonna et al.

Ingår i Nature Biotechnology, s. 1042-1055, 2022

• DOI för Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.
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Insulin granule biogenesis and exocytosis

Omar-Hmeadi, Muhmmad; Idevall Hagren, Olof

Ingår i Cellular and Molecular Life Sciences (CMLS), s. 1957-1970, 2021

• DOI för Insulin granule biogenesis and exocytosis
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RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function

Ibrahim, Hazem; Balboa, Diego; Saarimäki-Vire, Jonna; Montaser, Hossam et al.

Ingår i Diabetologia, s. 1642-1662, 2024

• DOI för RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function
• Ladda ner fulltext (pdf) av RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function

Local PI(4,5)P₂ signaling inhibits fusion pore expansion during exocytosis

Omar-Hmeadi, Muhmmad; Gucek, Alenka; Barg, Sebastian

Ingår i Cell Reports, 2023

• DOI för Local PI(4,5)P₂ signaling inhibits fusion pore expansion during exocytosis
• Ladda ner fulltext (pdf) av Local PI(4,5)P₂ signaling inhibits fusion pore expansion during exocytosis

Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets

Golec, Ewelina; Ekstrom, Alexander; Noga, Maciej; Omar-Hmeadi, Muhmmad et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2022

• DOI för Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets
• Ladda ner fulltext (pdf) av Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets

Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.

Balboa, Diego; Barsby, Tom; Lithovius, Väinö; Saarimäki-Vire, Jonna et al.

Ingår i Nature Biotechnology, s. 1042-1055, 2022

• DOI för Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.
• Ladda ner fulltext (pdf) av Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.

Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.

Omar-Hmeadi, Muhmmad; Lund, Per-Eric; Gandasi, Nikhil; Tengholm, Anders et al.

Ingår i Nature Communications, 2020

• DOI för Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.
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Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis

Gucek, Alenka; Gandasi, Nikhil R; Omar-Hmeadi, Muhmmad; Bakke, Marit et al.

Ingår i eLIFE, 2019

• DOI för Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis
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The Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 is Essential for Proinsulin Handling

Mojtaba Ghiasi, Seyed; Dahlby, Tina; Hede Andersen, Caroline; Haataja, Leena et al.

Ingår i Diabetes, s. 747-760, 2019

• DOI för The Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 is Essential for Proinsulin Handling

Glucose-Dependent Granule Docking Limits Insulin Secretion and Is Decreased in Human Type 2 Diabetes

Gandasi, Nikhil R; Yin, Peng; Omar-Hmeadi, Muhmmad; Ottosson Laakso, Emilia et al.

Ingår i Cell Metabolism, s. 470-478, 2018

• DOI för Glucose-Dependent Granule Docking Limits Insulin Secretion and Is Decreased in Human Type 2 Diabetes

PtdIns(4,5)P₂ is not required for secretory granule docking

Omar-Hmeadi, Muhmmad; Gandasi, Nikhil R; Barg, Sebastian

Ingår i Traffic, s. 436-445, 2018

• DOI för PtdIns(4,5)P₂ is not required for secretory granule docking

Syntaxin clusters at secretory granules in a munc18-bound conformation

Yin, Peng; Gandasi, Nikhil R.; Arora, Swati; Omar-Hmeadi, Muhmmad et al.

Ingår i Molecular Biology of the Cell, s. 2700-2708, 2018

• DOI för Syntaxin clusters at secretory granules in a munc18-bound conformation
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Plasma membrane PI(4,5)P-2 is critical for secretory granule exocytosis

Omar-Hmeadi, Muhmmad; Gandasi, Nikhil R.; Barg, Sebastian

Ingår i Molecular Biology of the Cell, s. 3727-3727, 2017

• DOI för Plasma membrane PI(4,5)P-2 is critical for secretory granule exocytosis

Insulin granule biogenesis and exocytosis

Omar-Hmeadi, Muhmmad; Idevall Hagren, Olof

Ingår i Cellular and Molecular Life Sciences (CMLS), s. 1957-1970, 2021

• DOI för Insulin granule biogenesis and exocytosis
• Ladda ner fulltext (pdf) av Insulin granule biogenesis and exocytosis

Regulation of docking and priming in pancreatic α- and β-cells

Omar-Hmeadi, Muhmmad

2019

• Ladda ner fulltext (pdf) av Regulation of docking and priming in pancreatic α- and β-cells

Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes

Omar-Hmeadi, Muhmmad; Lund, Per-Eric; Gandasi, Nikhil; Tengholm, Anders et al.

Fusion pore regulation by transient local generation of PI(4,5)P₂ in pancreatic in β-cells

Omar-Hmeadi, Muhmmad; Gucek, Alenka; Barg, Sebastian