Malin Lagerström – Sensoriska kretsar

Central role for fast nociceptors in mechanical nocifensive behavior and sensitization

Chen, John Chwen-Yu; Thorell, Oumie; Meira de-Faria, Felipe; Ahemaiti, Aikeremu et al.

Ingår i Nature Communications, 2026

• DOI för Central role for fast nociceptors in mechanical nocifensive behavior and sensitization
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Connectivity of neuropeptide Y-Cre spinal interneurons reveal monosynaptic inputs from pathways involved in pain and itch in mice

Magnusson, Kajsa A.; Ceder, Mikaela M.; Henriksson, Katharina; Lagerström, Malin C.

Ingår i Journal of Pain, 2026

• DOI för Connectivity of neuropeptide Y-Cre spinal interneurons reveal monosynaptic inputs from pathways involved in pain and itch in mice
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Slc6a9 is distributed in glial cells and neurons across several nervous system regions, whereas Slc6a5 is more restricted to neurons in the caudal brain

Ceder, Mikaela M.; Lagerström, Malin C.

Ingår i BMC Neuroscience, 2026

• DOI för Slc6a9 is distributed in glial cells and neurons across several nervous system regions, whereas Slc6a5 is more restricted to neurons in the caudal brain
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Neural ensembles that encode nocifensive mechanical and heat pain in mouse spinal cord

Zhang, Ming-Dong; Kupari, Jussi; Su, Jie; Magnusson, Kajsa A. et al.

Ingår i Nature Neuroscience, s. 1012-1023, 2025

• DOI för Neural ensembles that encode nocifensive mechanical and heat pain in mouse spinal cord
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Spinal lumbar Urocortin 3-expressing neurons are associated with both scratching and Compound 48/80-induced sensations

Franck, Marina C M; Weman, Hannah M; Ceder, Mikaela M; Ahemaiti, Aikeremu et al.

Ingår i Pain, s. 1070-1087, 2025

• DOI för Spinal lumbar Urocortin 3-expressing neurons are associated with both scratching and Compound 48/80-induced sensations
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Spinal Glycine Receptor Alpha 3 Cells Communicate Sensations of Chemical Itch in Hairy Skin

Weman, Hannah M.; Ceder, Mikaela M.; Ahemaiti, Aikeremu; Magnusson, Kajsa A. et al.

Ingår i Journal of Neuroscience, 2024

• DOI för Spinal Glycine Receptor Alpha 3 Cells Communicate Sensations of Chemical Itch in Hairy Skin

The mRNA expression profile of glycine receptor subunits alpha 1, alpha 2, alpha 4 and beta in female and male mice

Ceder, Mikaela M.; Magnusson, Kajsa A.; Weman, Hannah M.; Henriksson, Katharina et al.

Ingår i Molecular and Cellular Neuroscience, 2024

• DOI för The mRNA expression profile of glycine receptor subunits alpha 1, alpha 2, alpha 4 and beta in female and male mice
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Adult spinal Dmrt3 neurons receive direct somatosensory inputs from ipsi- and contralateral primary afferents and from brainstem motor nuclei

Vieillard, Jennifer; Franck, Marina C. M.; Hartung, Sunniva; Jakobsson, Jon E. T. et al.

Ingår i Journal of Comparative Neurology, s. 5-24, 2023

• DOI för Adult spinal Dmrt3 neurons receive direct somatosensory inputs from ipsi- and contralateral primary afferents and from brainstem motor nuclei
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The glycine receptor alpha 3 subunit mRNA expression shows sex-dependent differences in the adult mouse brain

Ceder, Mikaela M.; Weman, Hannah M.; Johansson, Ebba; Henriksson, Katharina et al.

Ingår i BMC Neuroscience, 2023

• DOI för The glycine receptor alpha 3 subunit mRNA expression shows sex-dependent differences in the adult mouse brain
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scConnect: a method for exploratory analysis of cell–cell communication based on single-cell RNA-sequencing data

Jakobsson, Jon E. T.; Spjuth, Ola; Lagerström, Malin C.

Ingår i Bioinformatics, s. 3501-3508, 2021

• DOI för scConnect: a method for exploratory analysis of cell–cell communication based on single-cell RNA-sequencing data
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Single cell transcriptomic analysis of spinal Dmrt3 neurons in zebrafish and mouse identifies distinct subtypes and reveal novel subpopulations within the dI6 domain

Iglesias Gonzalez, Ana Belen; Jakobsson, Jon E. T.; Vieillard, Jennifer; Lagerström, Malin C. et al.

Ingår i Frontiers in Cellular Neuroscience, 2021

• DOI för Single cell transcriptomic analysis of spinal Dmrt3 neurons in zebrafish and mouse identifies distinct subtypes and reveal novel subpopulations within the dI6 domain
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Targeting barrel field spiny stellate cells using a vesicular monoaminergic transporter 2-Cre mouse line

Freitag, Fabio B.; Ahemaiti, Aikeremu; Weman, Hannah M.; Ambroz, Katharina et al.

Ingår i Scientific Reports, 2021

• DOI för Targeting barrel field spiny stellate cells using a vesicular monoaminergic transporter 2-Cre mouse line
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Amelioration of Compound 48/80-Mediated Itch and LL-37-Induced Inflammation by a Single-Stranded Oligonucleotide

Dondalska, Aleksandra; Ronnberg, Elin; Ma, Haisha; Palsson, Sandra Axberg et al.

Ingår i Frontiers in Immunology, 2020

• DOI för Amelioration of Compound 48/80-Mediated Itch and LL-37-Induced Inflammation by a Single-Stranded Oligonucleotide
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Mouse connective tissue mast cell proteases tryptase and carboxypeptidase A3 play protective roles in itch induced by endothelin-1

Magnúsdóttir, Elín Ingibjörg; Grujic, Mirjana; Bergman, Jessica; Pejler, Gunnar et al.

Ingår i Journal of Neuroinflammation, 2020

• DOI för Mouse connective tissue mast cell proteases tryptase and carboxypeptidase A3 play protective roles in itch induced by endothelin-1
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The Neuropeptide Y Y-2 Receptor Is Coexpressed with Nppb in Primary Afferent Neurons and Y-2 Activation Reduces Histaminergic and IL-31-Induced Itch

Ma, Haisha; Gao, Tianle; Jakobsson, Jon E. T.; Weman, Hannah M. et al.

Ingår i Journal of Pharmacology and Experimental Therapeutics, s. 73-82, 2020

• DOI för The Neuropeptide Y Y-2 Receptor Is Coexpressed with Nppb in Primary Afferent Neurons and Y-2 Activation Reduces Histaminergic and IL-31-Induced Itch
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Neuropeptide Y in itch regulation

Jakobsson, Jon E. T.; Ma, Haisha; Lagerström, Malin C.

Ingår i Neuropeptides, 2019

• DOI för Neuropeptide Y in itch regulation
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Spinal gastrin releasing peptide receptor expressing interneurons are controlled by local phasic and tonic inhibition

Freitag, Fabio Batista; Ahemaiti, Aikeremu; Jakobsson, Jon E. T.; Weman, Hannah M. et al.

Ingår i Scientific Reports, 2019

• DOI för Spinal gastrin releasing peptide receptor expressing interneurons are controlled by local phasic and tonic inhibition
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CGRP alpha within the Trpv1-Cre population contributes to visceral nociception

Spencer, Nick J.; Magnúsdóttir, Elín Ingibjörg; Jakobsson, Jon E. T.; Kestell, Garreth et al.

Ingår i American Journal of Physiology - Gastrointestinal and Liver Physiology, 2018

• DOI för CGRP alpha within the Trpv1-Cre population contributes to visceral nociception

Mouse mast cells and mast cell proteases do not play a significant role in acute tissue injury pain induced by formalin

Magnúsdóttir, Elín Ingibjörg; Grujic, Mirjana; Roers, Axel; Hartmann, Karin et al.

Ingår i Molecular Pain, 2018

• DOI för Mouse mast cells and mast cell proteases do not play a significant role in acute tissue injury pain induced by formalin
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Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types

Haring, Martin; Zeisel, Amit; Hochgerner, Hannah; Rinwa, Puneet et al.

Ingår i Nature Neuroscience, s. 869-880, 2018

• DOI för Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types

The Neuropeptide Y System Regulates Both Mechanical and Histaminergic Itch

Gao, Tianle; Ma, Haisha; Xu, Bo; Bergman, Jessica et al.

Ingår i Journal of Investigative Dermatology, s. 2405-2411, 2018

• DOI för The Neuropeptide Y System Regulates Both Mechanical and Histaminergic Itch
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Visceral pain: Novel approaches for optogenetic control of spinal afferents

Spencer, Nick J.; Hibberd, Tim J.; Lagerström, Malin; Otsuka, Yoichiro et al.

Ingår i Brain Research, s. 159-164, 2018

• DOI för Visceral pain: Novel approaches for optogenetic control of spinal afferents

Spinal Cord Interneurons Expressing the Gastrin-Releasing Peptide Receptor Convey Itch Through VGLUT2-Mediated Signaling

Aresh, Bejan; Freitag, Fabio B.; Perry, Sharn; Blümel, Edda et al.

Ingår i Pain, s. 945-961, 2017

• DOI för Spinal Cord Interneurons Expressing the Gastrin-Releasing Peptide Receptor Convey Itch Through VGLUT2-Mediated Signaling
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Identification of a Neuronal Receptor Controlling Anaphylaxis

Rogoz, Katarzyna; Aresh, Bejan; Freitag, Fabio Batista; Pettersson, Hanna et al.

Ingår i Cell Reports, s. 370-379, 2016

• DOI för Identification of a Neuronal Receptor Controlling Anaphylaxis
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Midbrain Gene Screening Identifies a New Mesoaccumbal Glutamatergic Pathway and a Marker for Dopamine Cells Neuroprotected in Parkinson's Disease

Viereckel, Thomas; Dumas, Sylvie; Smith-Anttila, Casey J. A.; Vlcek, Bianca et al.

Ingår i Scientific Reports, 2016

• DOI för Midbrain Gene Screening Identifies a New Mesoaccumbal Glutamatergic Pathway and a Marker for Dopamine Cells Neuroprotected in Parkinson's Disease
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Sinomenine is a promising analgesic and anti-hyperalgesic for pain and hypersensitivity in rheumatoid arthritis

Lagerström, Malin C.

Ingår i Scandinavian Journal of Pain, s. 15-16, 2015

• DOI för Sinomenine is a promising analgesic and anti-hyperalgesic for pain and hypersensitivity in rheumatoid arthritis

The anti-inflammatory alkaloid aloperine in Chinese herbal medicine is potentially useful for management of pain and itch

Gao, Tianle; Lagerström, Malin C.

Ingår i Scandinavian Journal of Pain, s. 25-26, 2015

• DOI för The anti-inflammatory alkaloid aloperine in Chinese herbal medicine is potentially useful for management of pain and itch

VGLUT2 controls heat and punctuate hyperalgesia associated with nerve injury via TRPV1-Cre primary afferents

Rogóz, Katarzyna; Stjarne, Ludvig; Kullander, Klas; Lagerström, Malin C.

Ingår i PLOS ONE, 2015

• DOI för VGLUT2 controls heat and punctuate hyperalgesia associated with nerve injury via TRPV1-Cre primary afferents
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Glutamate, Substance P, and Calcitonin Gene-Related Peptide Cooperate in Inflammation-Induced Heat Hyperalgesia

Rogoz, Katarzyna; Andersen, Helena Haddadi; Kullander, Klas; Lagerström, Malin C.

Ingår i Molecular Pharmacology, s. 322-334, 2014

• DOI för Glutamate, Substance P, and Calcitonin Gene-Related Peptide Cooperate in Inflammation-Induced Heat Hyperalgesia

Multimodal Use of Calcitonin Gene-Related Peptide and Substance P in Itch and Acute Pain Uncovered by the Elimination of Vesicular Glutamate Transporter 2 from Transient Receptor Potential Cation Channel Subfamily V Member 1 Neurons

Rogóz, Katarzyna; Andersen, Helena H.; Lagerström, Malin C.; Kullander, Klas

Ingår i Journal of Neuroscience, s. 14055-14068, 2014

• DOI för Multimodal Use of Calcitonin Gene-Related Peptide and Substance P in Itch and Acute Pain Uncovered by the Elimination of Vesicular Glutamate Transporter 2 from Transient Receptor Potential Cation Channel Subfamily V Member 1 Neurons

Synaptic changes induced by melanocortin signalling

Caruso, Vanni; Lagerström, Malin C.; Olszewski, Pawel K.; Fredriksson, Robert et al.

Ingår i Nature Reviews Neuroscience, s. 98-110, 2014

• DOI för Synaptic changes induced by melanocortin signalling

Vglut2-Regulated Itch - Primary Afferents And Beyond

Lagerström, Malin

Ingår i Acta Dermato-Venereologica, s. 607-607, 2013

VGLUT2-dependent glutamatergic transmission in primary afferents is required for intact nociception in both acute and persistent pain modalities

Rogoz, Katarzyna; Lagerström, Malin C.; Dufour, Sylvie; Kullander, Klas

Ingår i Pain, s. 1525-1536, 2012

• DOI för VGLUT2-dependent glutamatergic transmission in primary afferents is required for intact nociception in both acute and persistent pain modalities

A sensory subpopulation depends on vesicular glutamate transporter 2 for mechanical pain, and together with substance P, inflammatory pain

Lagerström, Malin C.; Rogoz, Katarzyna; Abrahamsen, Bjarke; Lind, Anne-Li et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 5789-5794, 2011

• DOI för A sensory subpopulation depends on vesicular glutamate transporter 2 for mechanical pain, and together with substance P, inflammatory pain

Nociceptor-expressed ephrin-B2 regulates inflammatory and neuropathic pain

Zhao, Jing; Yuan, Guanglu; Cendan, Cruz M.; Nassar, Mohammed A. et al.

Ingår i Molecular Pain, s. 77, 2010

• DOI för Nociceptor-expressed ephrin-B2 regulates inflammatory and neuropathic pain

VGLUT2-Dependent Sensory Neurons in the TRPV1 Population Regulate Pain and Itch

Lagerström, Malin C.; Rogoz, Katarzyna; Abrahamsen, Bjarke; Persson, Emma et al.

Ingår i Neuron, s. 529-542, 2010

• DOI för VGLUT2-Dependent Sensory Neurons in the TRPV1 Population Regulate Pain and Itch

Restricted cortical and amygdaloid removal of vesicular glutamate transporter 2 in preadolescent mice impacts dopaminergic activity and neuronal circuitry of higher brain function

Wallén-Mackenzie, Åsa; Nordenankar, Karin; Fejgin, Kim; Lagerström, Malin C et al.

Ingår i Journal of Neuroscience, s. 2238-2251, 2009

• DOI för Restricted cortical and amygdaloid removal of vesicular glutamate transporter 2 in preadolescent mice impacts dopaminergic activity and neuronal circuitry of higher brain function

The Secretin GPCRs descended from the family of Adhesion GPCRs

Nordström, Karl J V; Lagerström, Malin C; Wallér, Linn M J; Fredriksson, Robert et al.

Ingår i Molecular biology and evolution, s. 71-84, 2009

• DOI för The Secretin GPCRs descended from the family of Adhesion GPCRs

Structural diversity of G protein-coupled receptors and significance for drug discovery

Lagerström, Malin C.; Schiöth, Helgi B.

Ingår i Nature reviews. Drug discovery, s. 339-357, 2008

• DOI för Structural diversity of G protein-coupled receptors and significance for drug discovery

The Adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury

Pickering, Chris; Hägglund, Maria; Szmydynger-Chodobska, Joanna; Marques, Fernanda et al.

Ingår i BMC Neuroscience, s. 97, 2008

• DOI för The Adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury

The evolutionary history and tissue mapping of GPR123: specific CNS expression pattern predominantly in thalamic nuclei and regions containing large pyramidal cells

Lagerström, Malin C.; Rabe, Nadine; Haitina, Tatjana; Kalnina, Ineta et al.

Ingår i Journal of Neurochemistry, s. 1129-1142, 2007

• DOI för The evolutionary history and tissue mapping of GPR123: specific CNS expression pattern predominantly in thalamic nuclei and regions containing large pyramidal cells

Role of glutamate in locomotor rhythm generating neuronal circuitry

Gezelius, Henrik; Wallén-Mackenzie, Åsa; Enjin, Anders; Lagerström, Malin et al.

Ingår i Journal of Physiology - Paris, s. 297-303, 2006

• DOI för Role of glutamate in locomotor rhythm generating neuronal circuitry

The G protein-coupled receptor subset of the chicken genome

Lagerström, Malin C.; Hellström, Anders R.; Gloriam, David E.; Larsson, Thomas P. et al.

Ingår i PloS Computational Biology, 2006

• DOI för The G protein-coupled receptor subset of the chicken genome

Origin of the prolactin-releasing hormone (PRLH) receptors: Evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution

Lagerström, Malin C.; Fredriksson, Robert; Bjarnadottir, Thora; Fridmanis, Davids et al.

Ingår i Genomics, s. 688-703, 2005

• DOI för Origin of the prolactin-releasing hormone (PRLH) receptors: Evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution

Cloning, tissue distribution, pharmacology and three-dimensional modelling of melanocortin receptors 4 and 5 in rainbow trout suggest close evolutionary relationship of these subtypes

Haitina, Tatjana; Klovins, Janis; Andersson, Jan; Fredriksson, Robert et al.

Ingår i Biochemical Journal, s. 475-486, 2004

• DOI för Cloning, tissue distribution, pharmacology and three-dimensional modelling of melanocortin receptors 4 and 5 in rainbow trout suggest close evolutionary relationship of these subtypes

The human and mouse repertoire of the adhesion family of G-protein-coupled receptors

Bjarnadóttir, Thóra K.; Fredriksson, Robert; Höglund, Pär J.; Gloriam, David E. et al.

Ingår i Genomics, s. 23-33, 2004

• DOI för The human and mouse repertoire of the adhesion family of G-protein-coupled receptors

High affinity agonistic metal ion binding sites within the melanocortin 4 receptor illustrate conformational change of transmembrane region 3

Lagerström, Malin C.; Klovins, Janis; Fredriksson, Robert; Fridmanis, Davids et al.

Ingår i Journal of Biological Chemistry, s. 51521-51526, 2003

• DOI för High affinity agonistic metal ion binding sites within the melanocortin 4 receptor illustrate conformational change of transmembrane region 3

The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families: Phylogenetic Analysis, Paralogon Groups, and Fingerprints

Fredriksson, Robert; Lagerström, Malin C.; Lundin, Lars-Gustav; Schiöth, Helgi B.

Ingår i Molecular Pharmacology, s. 1256-1272, 2003

• DOI för The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families: Phylogenetic Analysis, Paralogon Groups, and Fingerprints

There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini

Fredriksson, Robert; Gloriam, David; Höglund, Pär; Lagerström, Malin et al.

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 752-734, 2003

• DOI för There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini

The chicken G protein-coupled receptor (GPCR)-ome

Lagerström, Malin C.; Hellström, Anders R.; Larsson, Thomas P.; Schiöth, Helgi B. et al.

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