Publikationer Peter Nygren

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Mansoori, Sharmineh; Blom, Kristin; Andersson, Claes; Fryknäs, Mårten et al.

Ingår i Oncology Reports, 2026

• DOI för Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model
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Efficacy of mebendazole in the spontaneous NZBxNZWF1 animal model of systemic lupus erythematosus

Eloranta, Maija-Leena; Nygren, Peter; Larsson, Rolf; Loskog, Angelica et al.

Ingår i Scientific Reports, 2026

• DOI för Efficacy of mebendazole in the spontaneous NZBxNZWF1 animal model of systemic lupus erythematosus
• Ladda ner fulltext (pdf) av Efficacy of mebendazole in the spontaneous NZBxNZWF1 animal model of systemic lupus erythematosus

Clinical characteristics and treatment outcome in p16 negative anal cancer

Burgos, Catherine; Radu, Calin; Heyman, Sofia; Cavalli-Björkman, Nina et al.

Ingår i Acta Oncologica, s. 633-640, 2025

• DOI för Clinical characteristics and treatment outcome in p16 negative anal cancer
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Ex vivo drug responses and molecular profiles of 597 pediatric acute lymphoblastic leukemia patients

Enblad, Anna Pia; Krali, Olga; Gezelius, Henrik; Lundmark, Anders et al.

Ingår i HemaSphere, 2025

• DOI för Ex vivo drug responses and molecular profiles of 597 pediatric acute lymphoblastic leukemia patients
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Feasibility and outcome of genomics-guided treatment selection in advanced cancer: the MEGALiT explorative clinical trial

Ny, Lars; Fagman, Henrik; Botling, Johan; Mantovaara, Loviisa et al.

Ingår i Acta Oncologica, s. 742-750, 2025

• DOI för Feasibility and outcome of genomics-guided treatment selection in advanced cancer: the MEGALiT explorative clinical trial
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Precision cancer medicine 2025: some concerns

Nygren, Peter

Ingår i Acta Oncologica, s. 1202-1204, 2025

• DOI för Precision cancer medicine 2025: some concerns
• Ladda ner fulltext (pdf) av Precision cancer medicine 2025: some concerns

Preoperative chemotherapy in colorectal peritoneal metastatic disease: a real-world observational cohort study

Cashin, Peter; Frühling, Petter; Grönlund, Pontus; Graf, Wilhelm et al.

Ingår i Pleura and Peritoneum, s. 1-10, 2025

• DOI för Preoperative chemotherapy in colorectal peritoneal metastatic disease: a real-world observational cohort study
• Ladda ner fulltext (pdf) av Preoperative chemotherapy in colorectal peritoneal metastatic disease: a real-world observational cohort study

A Randomized Phase III Study of Arfolitixorin versus Leucovorin with 5-Fluorouracil, Oxaliplatin, and Bevacizumab for First-Line Treatment of Metastatic Colorectal Cancer: The AGENT Trial

Tabernero, Josep; Yoshino, Takayuki; Stintzing, Sebastian; de Gramont, Aimery et al.

Ingår i Cancer Research Communications, s. 28-37, 2024

• DOI för A Randomized Phase III Study of Arfolitixorin versus Leucovorin with 5-Fluorouracil, Oxaliplatin, and Bevacizumab for First-Line Treatment of Metastatic Colorectal Cancer: The AGENT Trial
• Ladda ner fulltext (pdf) av A Randomized Phase III Study of Arfolitixorin versus Leucovorin with 5-Fluorouracil, Oxaliplatin, and Bevacizumab for First-Line Treatment of Metastatic Colorectal Cancer: The AGENT Trial

Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment

Selvin, Tove; Berglund, Malin; Lenhammar, Lena; Lindskog, Magnus et al.

Ingår i BMC Pharmacology & Toxicology, 2024

• DOI för Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment
• Ladda ner fulltext (pdf) av Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment

Assessment in vitro of interactions between anti-cancer drugs and noncancer drugs commonly used by cancer patients

Andersson, Claes; Ye, Jiawei; Blom, Kristin; Fryknäs, Mårten et al.

Ingår i Anti-Cancer Drugs, s. 92-102, 2023

• DOI för Assessment in vitro of interactions between anti-cancer drugs and noncancer drugs commonly used by cancer patients
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Ex vivo assessment of chemotherapy sensitivity of colorectal cancer peritoneal metastases

Cashin, Peter; Söderström, Maria; Blom, Kristin; Artursson, Sara et al.

Ingår i British Journal of Surgery, s. 1080-1083, 2023

• DOI för Ex vivo assessment of chemotherapy sensitivity of colorectal cancer peritoneal metastases
• Ladda ner fulltext (pdf) av Ex vivo assessment of chemotherapy sensitivity of colorectal cancer peritoneal metastases

Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death

Selvin, Tove; Berglund, Malin; Lenhammar, Lena; Jarvius, Malin et al.

Ingår i BMC Cancer, 2023

• DOI för Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death
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The value of post-operative chemotherapy after chemoradiotherapy in patients with high-risk locally advanced rectal cancerdresults from the RAPIDO trial

Dijkstra, E. A.; Zwart, W. H.; Nilsson, P. J.; Putter, H. et al.

Ingår i ESMO Open, 2023

• DOI för The value of post-operative chemotherapy after chemoradiotherapy in patients with high-risk locally advanced rectal cancerdresults from the RAPIDO trial

Evaluation and validation of chemotherapy‐specific diarrhoea and histopathology in rats

Dahlgren, David; Rosenqvist, Evelina; Hellström, Per M.; Nygren, Peter et al.

Ingår i Basic & Clinical Pharmacology & Toxicology, s. 536-546, 2022

• DOI för Evaluation and validation of chemotherapy‐specific diarrhoea and histopathology in rats
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Ex vivo assessment of cancer drug sensitivity in epithelial ovarian cancer and its association with histopathological type, treatment history and clinical outcome

Bjersand, Kathrine; Blom, Kristin; Sundström Poromaa, Inger; Stålberg, Karin et al.

Ingår i International Journal of Oncology, 2022

• DOI för Ex vivo assessment of cancer drug sensitivity in epithelial ovarian cancer and its association with histopathological type, treatment history and clinical outcome
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Selective radiosensitization by nitazoxanide of quiescent clonogenic colon cancer tumour cells

Karlsson, Henning; Fryknäs, Mårten; Senkowski, Wojciech; Larsson, Rolf et al.

Ingår i Oncology Letters, 2022

• DOI för Selective radiosensitization by nitazoxanide of quiescent clonogenic colon cancer tumour cells
• Ladda ner fulltext (pdf) av Selective radiosensitization by nitazoxanide of quiescent clonogenic colon cancer tumour cells

Sorafenib and nitazoxanide disrupt mitochondrial function and inhibit regrowth capacity in three-dimensional models of hepatocellular and colorectal carcinoma

Nyberg, Frida; Blom, Kristin; Selvin, Tove; Rudfeldt, Jakob et al.

Ingår i Scientific Reports, 2022

• DOI för Sorafenib and nitazoxanide disrupt mitochondrial function and inhibit regrowth capacity in three-dimensional models of hepatocellular and colorectal carcinoma
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A phase 2a clinical study on the safety and efficacy of individualized dosed mebendazole in patients with advanced gastrointestinal cancer

Mansoori, Sharmineh; Fryknäs, Mårten; Alvfors, Carina; Loskog, Angelica et al.

Ingår i Scientific Reports, 2021

• DOI för A phase 2a clinical study on the safety and efficacy of individualized dosed mebendazole in patients with advanced gastrointestinal cancer
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Does exercise intensity matter for fatigue during (neo)adjuvant cancer treatment?: The PhysCan randomized clinical trial

Demmelmaier, Ingrid; Brooke, Hannah L.; Henriksson, Anna; Mazzoni, Anne-Sophie et al.

Ingår i Scandinavian Journal of Medicine and Science in Sports, s. 1144-1159, 2021

• DOI för Does exercise intensity matter for fatigue during (neo)adjuvant cancer treatment?: The PhysCan randomized clinical trial
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Fördelaktigt med genetisk analys före behandling med 5-fluorouracil: Utvärdering tyder på mindre biverkningar och kostnadsbesparing för sjukvården: [New recommendation on pharmacogenetic screening prior to 5-fluorouracil based cancer treatment - Swedish experience indicates less adverse effects and healthcare cost savings]

Schultz, Alice; Kohnke, Hugo; Wadelius, Mia; Nygren, Peter

Ingår i Läkartidningen, 2021

Cocreated internet-based stepped care for individuals with cancer and concurrent symptoms of anxiety and depression: Results from the U-CARE AdultCan randomized controlled trial

Hauffman, Anna; Alfonsson, Sven; Bill-Axelson, Anna; Bergkvist, Leif et al.

Ingår i Psycho-Oncology, s. 2012-2018, 2020

• DOI för Cocreated internet-based stepped care for individuals with cancer and concurrent symptoms of anxiety and depression: Results from the U-CARE AdultCan randomized controlled trial
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Effects of a nutrition intervention on acute and late bowel symptoms and health-related quality of life up to 24 months post radiotherapy in patients with prostate cancer: a multicentre randomised controlled trial.

Forslund, Marina; Ottenblad, Anna; Ginman, Claes; Johansson, Silvia et al.

Ingår i Supportive Care in Cancer, s. 3331-3342, 2020

• DOI för Effects of a nutrition intervention on acute and late bowel symptoms and health-related quality of life up to 24 months post radiotherapy in patients with prostate cancer: a multicentre randomised controlled trial.
• Ladda ner fulltext (pdf) av Effects of a nutrition intervention on acute and late bowel symptoms and health-related quality of life up to 24 months post radiotherapy in patients with prostate cancer: a multicentre randomised controlled trial.

Experiences of a nutrition intervention: A qualitative study within a randomised controlled trial in men undergoing radiotherapy for prostate cancer

Forslund, Marina; Nygren, Peter; Ottenblad, Anna; Johansson, Birgitta

Ingår i Nutrition & Dietetics, s. 223-230, 2020

• DOI för Experiences of a nutrition intervention: A qualitative study within a randomised controlled trial in men undergoing radiotherapy for prostate cancer

Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

Rendo, Verónica; Stoimenov, Ivaylo; Mateus, André; Sjöberg, Elin et al.

Ingår i Nature Communications, 2020

• DOI för Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy
• Ladda ner fulltext (pdf) av Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

Mebendazole is unique among tubulin-active drugs in activating the MEK-ERK pathway

Andersson, Claes; Selvin, Tove; Blom, Kristin; Rubin, Jenny et al.

Ingår i Scientific Reports, 2020

• DOI för Mebendazole is unique among tubulin-active drugs in activating the MEK-ERK pathway
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Ultrasound-guided Percutaneous Irreversible Electroporation for Treatment of Locally Recurrent Pancreatic Cancer After Surgical Resection

Månsson, Christopher; Nilsson, Anders; Nygren, Peter; Karlson, Britt-Marie

Ingår i Anticancer Research, s. 2771-2775, 2020

• DOI för Ultrasound-guided Percutaneous Irreversible Electroporation for Treatment of Locally Recurrent Pancreatic Cancer After Surgical Resection

A phase I study of the safety and tolerability of VLX600, an Iron Chelator, in patients with refractory advanced solid tumors

Mody, Kabir; Mansfield, Aaron S.; Vemireddy, Lalitha; Nygren, Peter et al.

Ingår i Investigational new drugs, s. 684-692, 2019

• DOI för A phase I study of the safety and tolerability of VLX600, an Iron Chelator, in patients with refractory advanced solid tumors

Lessons learned from the maturation of a cancer drug: oxaliplatin in colorectal cancer

Glimelius, Bengt; Nygren, Peter

Ingår i Acta Oncologica, s. 395-397, 2019

• DOI för Lessons learned from the maturation of a cancer drug: oxaliplatin in colorectal cancer

Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition

Blom, Kristin; Eriksson, Jenny; Berglund, Malin; Jarvius, Malin et al.

Ingår i BMC Research Notes, 2019

• DOI för Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition
• Ladda ner fulltext (pdf) av Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition

Percutaneous Irreversible Electroporation as First Line Treatment of Locally Advanced Pancreatic Cancer

Månsson, Christopher; Brahmstaedt, Richard; Nygren, Peter; Nilsson, Anders et al.

Ingår i Anticancer Research, s. 2509-2512, 2019

• DOI för Percutaneous Irreversible Electroporation as First Line Treatment of Locally Advanced Pancreatic Cancer

Which exercise prescriptions optimize V̇O₂max during cancer treatment?: a systematic review and meta-analysis

Bjorke, Ann Christin Helgesen; Sweegers, Maike G.; Buffart, Laurien M.; Raastad, Truls et al.

Ingår i Scandinavian Journal of Medicine and Science in Sports, s. 1274-1287, 2019

• DOI för Which exercise prescriptions optimize V̇O₂max during cancer treatment?: a systematic review and meta-analysis

Ex Vivo Activity of Cytotoxic Drugs and Targeted Agents in Small Intestinal Neuroendocrine Tumors

Daskalakis, Kosmas; Norlén, Olov; Karakatsanis, Andreas; Hellman, Per et al.

Ingår i Neuroendocrinology, s. 189-189, 2018

• DOI för Ex Vivo Activity of Cytotoxic Drugs and Targeted Agents in Small Intestinal Neuroendocrine Tumors

Ex vivo activity of cytotoxic drugs and targeted agents in small intestinal neuroendocrine tumors

Daskalakis, Kosmas; Norlén, Olov; Karakatsanis, Andreas; Hellman, Per et al.

Ingår i Endocrine-Related Cancer, s. 471-480, 2018

• DOI för Ex vivo activity of cytotoxic drugs and targeted agents in small intestinal neuroendocrine tumors

U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden.

Glimelius, Bengt; Melin, Beatrice; Enblad, Gunilla; Alafuzoff, Irina et al.

Ingår i Acta Oncologica, s. 187-194, 2018

• DOI för U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden.
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Bliss and Loewe interaction analyses of clinically relevant drug combinations in human colon cancer cell lines reveal complex patterns of synergy and antagonism

Kashif, Muhammad; Andersson, Claes; Mansoori, Sharmineh; Larsson, Rolf et al.

Ingår i Oncotarget, s. 103952-103967, 2017

• DOI för Bliss and Loewe interaction analyses of clinically relevant drug combinations in human colon cancer cell lines reveal complex patterns of synergy and antagonism
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Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity

Karlsson, Henning; Fryknäs, Mårten; Strese, Sara; Gullbo, Joachim et al.

Ingår i Oncotarget, s. 30217-30234, 2017

• DOI för Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity
• Ladda ner fulltext (pdf) av Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity

Melflufen: a peptidase-potentiated alkylating agent in clinical trials

Wickström, Malin; Nygren, Peter; Larsson, Rolf; Harmenberg, Johan et al.

Ingår i Oncotarget, s. 66641-66655, 2017

• DOI för Melflufen: a peptidase-potentiated alkylating agent in clinical trials
• Ladda ner fulltext (pdf) av Melflufen: a peptidase-potentiated alkylating agent in clinical trials

Predictive Value of Ex Vivo Chemosensitivity Assays for Individualized Cancer Chemotherapy: A Meta-Analysis

Blom, Kristin; Nygren, Peter; Larsson, Rolf; Andersson, Claes R.

Ingår i SLAS TECHNOLOGY, s. 306-314, 2017

• DOI för Predictive Value of Ex Vivo Chemosensitivity Assays for Individualized Cancer Chemotherapy: A Meta-Analysis

Prognostic factors in patients with loco-regionally advanced gastric cancer

Hultman, Bo; Gunnarsson, Ulf; Nygren, Peter; Sundbom, Magnus et al.

Ingår i World Journal of Surgical Oncology, 2017

• DOI för Prognostic factors in patients with loco-regionally advanced gastric cancer
• Ladda ner fulltext (pdf) av Prognostic factors in patients with loco-regionally advanced gastric cancer

Targeting tumor cells based on Phosphodiesterase 3A expression

Nazir, Madiha; Senkowski, Wojciech; Nyberg, Frida; Blom, Kristin et al.

Ingår i Experimental Cell Research, s. 308-315, 2017

• DOI för Targeting tumor cells based on Phosphodiesterase 3A expression

The anticancer effect of mebendazole may be due to M1 monocyte/macrophage activation via ERK1/2 and TLR8-dependent inflammasome activation

Blom, Kristin; Senkowski, Wojciech; Jarvius, Malin; Berglund, Malin et al.

Ingår i Immunopharmacology and immunotoxicology, s. 199-210, 2017

• DOI för The anticancer effect of mebendazole may be due to M1 monocyte/macrophage activation via ERK1/2 and TLR8-dependent inflammasome activation

The development of a Nurse-led Internet-based Learning and Self-care program for cancer patients with symptoms of anxiety and depression: a part of U-CARE

Hauffman, Anna; Alfonsson, Sven; Mattson, Susanne; Forslund, Marina et al.

Ingår i Cancer Nursing, 2017

• DOI för The development of a Nurse-led Internet-based Learning and Self-care program for cancer patients with symptoms of anxiety and depression: a part of U-CARE
• Ladda ner fulltext (pdf) av The development of a Nurse-led Internet-based Learning and Self-care program for cancer patients with symptoms of anxiety and depression: a part of U-CARE

Towards repositioning of quinacrine for treatment of acute myeloid leukemia - Promising synergies and in vivo effects.

Eriksson, Anna; Chantzi, Efthymia; Fryknäs, Mårten; Gullbo, Joachim et al.

Ingår i Leukemia Research, s. 41-46, 2017

• DOI för Towards repositioning of quinacrine for treatment of acute myeloid leukemia - Promising synergies and in vivo effects.
• Ladda ner fulltext (pdf) av Towards repositioning of quinacrine for treatment of acute myeloid leukemia - Promising synergies and in vivo effects.

Differences in trial knowledge and motives for participation among cancer patients in phase 3 clinical trials

Godskesen, Tove; Kihlbom, Ulrik; Nordin, Karin; Silen, Marit et al.

Ingår i European Journal of Cancer Care, s. 516-523, 2016

• DOI för Differences in trial knowledge and motives for participation among cancer patients in phase 3 clinical trials

Ex Vivo Assessment of Drug Activity in Patient Tumor Cells as a Basis for Tailored Cancer Therapy

Blom, Kristin; Nygren, Peter; Alvarsson, Jonathan; Larsson, Rolf et al.

Ingår i JALA, s. 178-187, 2016

• DOI för Ex Vivo Assessment of Drug Activity in Patient Tumor Cells as a Basis for Tailored Cancer Therapy

High sensitivity isoelectric focusing to establish a signaling biomarker for the diagnosis of human colorectal cancer

Padhan, Narendra; Nordling, Torbjorn E. M.; Sundström, Magnus; Åkerud, Peter et al.

Ingår i BMC Cancer, 2016

• DOI för High sensitivity isoelectric focusing to establish a signaling biomarker for the diagnosis of human colorectal cancer
• Ladda ner fulltext (pdf) av High sensitivity isoelectric focusing to establish a signaling biomarker for the diagnosis of human colorectal cancer

Iron chelators target both proliferating and quiescent cancer cells

Fryknäs, Mårten; Zhang, Xiaonan; Bremberg, Ulf; Senkowski, Wojciech et al.

Ingår i Scientific Reports, 2016

• DOI för Iron chelators target both proliferating and quiescent cancer cells
• Ladda ner fulltext (pdf) av Iron chelators target both proliferating and quiescent cancer cells

Large-Scale Gene Expression Profiling Platform for Identification of Context-Dependent Drug Responses in Multicellular Tumor Spheroids

Senkowski, Wojciech; Jarvius, Malin; Rubin, Jenny; Lengqvist, Johan et al.

Ingår i CELL CHEMICAL BIOLOGY, s. 1428-1438, 2016

• DOI för Large-Scale Gene Expression Profiling Platform for Identification of Context-Dependent Drug Responses in Multicellular Tumor Spheroids

Oxaliplatin added to fluoropyrimidine for adjuvant treatment of colorectal cancer is associated with long-term impairment of peripheral nerve sensory function and quality of life

Stefansson, Måns; Nygren, Peter

Ingår i Acta Oncologica, s. 1227-1235, 2016

• DOI för Oxaliplatin added to fluoropyrimidine for adjuvant treatment of colorectal cancer is associated with long-term impairment of peripheral nerve sensory function and quality of life

Percutaneous irreversible electroporation for treatment of locally advanced pancreatic cancer following chemotherapy or radiochemotherapy

Månsson, Christopher; Brahmstaedt, Richard; Nilsson, Anders; Nygren, Peter et al.

Ingår i European Journal of Surgical Oncology, s. 1401-1406, 2016

• DOI för Percutaneous irreversible electroporation for treatment of locally advanced pancreatic cancer following chemotherapy or radiochemotherapy

Preclinical activity of melflufen (J1) in ovarian cancer

Carlier, Charlotte; Strese, Sara; Viktorsson, Kristina; Velander, Ebba et al.

Ingår i Oncotarget, s. 59322-59335, 2016

• DOI för Preclinical activity of melflufen (J1) in ovarian cancer

Repositioning Of Quinacrine For Treatment Of Acute Myeloid Leukemia - Synergies And In Vivo Effects

Eriksson, Anna; Gustafsson, Mats; Fryknäs, Mårten; Gullbo, Joachim et al.

Ingår i Haematologica, s. 367-368, 2016

Uptake, delivery, and anticancer activity of thymoquinone nanoparticles in breast cancer cells

Fakhoury, Isabelle; Saad, Walid; Bouhadir, Kamal; Nygren, Peter et al.

Ingår i Journal of nanoparticle research, 2016

• DOI för Uptake, delivery, and anticancer activity of thymoquinone nanoparticles in breast cancer cells

Always look at the bright side of drugs?

Nygren, Peter

Ingår i Acta Oncologica, s. 145-147, 2015

• DOI för Always look at the bright side of drugs?

Considerations on the Selection Process for Cytoreductive Surgery and Hyperthermic IntraPeritoneal Chemotherapy for Colorectal Carcinomatosis Reply

Cashin, Peter; Graf, Wilhelm; Nygren, Peter; Mahteme, Haile

Ingår i Annals of Surgery, 2015

Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia

Eriksson, Anna; Österroos, Albin; Hassan, Sadia Bashir; Gullbo, Joachim et al.

Ingår i Blood Cancer Journal, 2015

• DOI för Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia
• Ladda ner fulltext (pdf) av Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia

Drug Sensitivity Testing in Cytoreductive Surgery and Intraperitoneal Chemotherapy of Pseudomyxoma Peritonei

Bjersand, Kathrine; Mahteme, Haile; Sundström Poromaa, Inger; Andreasson, Håkan et al.

Ingår i Annals of Surgical Oncology, 2015

• DOI för Drug Sensitivity Testing in Cytoreductive Surgery and Intraperitoneal Chemotherapy of Pseudomyxoma Peritonei

First-in-human, phase I/IIa clinical study of the peptidase potentiated alkylator melflufen administered every three weeks to patients with advanced solid tumor malignancies

Berglund, Åke; Ullen, Anders; Lisyanskaya, Alla; Orlov, Sergey et al.

Ingår i Investigational new drugs, s. 1232-1241, 2015

• DOI för First-in-human, phase I/IIa clinical study of the peptidase potentiated alkylator melflufen administered every three weeks to patients with advanced solid tumor malignancies

Hope for a cure and altruism are the main motives behind participation in phase 3 clinical cancer trials

Godskesen, Tove; Hansson, Mats G.; Nygren, Peter; Nordin, Karin et al.

Ingår i European Journal of Cancer Care, s. 133-141, 2015

• DOI för Hope for a cure and altruism are the main motives behind participation in phase 3 clinical cancer trials

In vitro discovery of promising anti-cancer drug combinations using iterative maximisation of a therapeutic index

Kashif, Muhammad; Andersson, Claes; Hassan, Sadia; Karlsson, Henning et al.

Ingår i Scientific Reports, 2015

• DOI för In vitro discovery of promising anti-cancer drug combinations using iterative maximisation of a therapeutic index
• Ladda ner fulltext (pdf) av In vitro discovery of promising anti-cancer drug combinations using iterative maximisation of a therapeutic index

Label free quantification of time evolving morphologies using time-lapse video microscopy enables identity control of cell lines and discovery of chemically induced differential activity in iso-genic cell line pairs

Aftab, Obaid; Fryknäs, Mårten; Hassan, Saadia; Nygren, Peter et al.

Ingår i Chemometrics and Intelligent Laboratory Systems, s. 24-32, 2015

• DOI för Label free quantification of time evolving morphologies using time-lapse video microscopy enables identity control of cell lines and discovery of chemically induced differential activity in iso-genic cell line pairs

O-15-Water PET Study of the Effect of Imatinib, a Selective Platelet-Derived Growth Factor Receptor Inhibitor, Versus Anakinra, an IL-1R Antagonist, on Water-Perfusable Tissue Fraction in Colorectal Cancer Metastases

Lubberink, Mark; Golla, Sanjeep S. V.; Jonasson, My; Rubin, Kristofer et al.

Ingår i Journal of Nuclear Medicine, s. 1144-1149, 2015

• DOI för O-15-Water PET Study of the Effect of Imatinib, a Selective Platelet-Derived Growth Factor Receptor Inhibitor, Versus Anakinra, an IL-1R Antagonist, on Water-Perfusable Tissue Fraction in Colorectal Cancer Metastases

Spheroid-based high throughput screening for identification of molecules targeting different tumor microenvironment characteristics

Senkowski, Wojciech; Zhang, Xiaonan; Nygren, Peter; Olofsson, Maria Hagg et al.

Ingår i Cancer Research, 2015

• DOI för Spheroid-based high throughput screening for identification of molecules targeting different tumor microenvironment characteristics

Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer

Senkowski, Wojciech; Zhang, Xiaonan; Olofsson, Maria Hagg; Isacson, Ruben et al.

Ingår i Molecular Cancer Therapeutics, s. 1504-1516, 2015

• DOI för Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer

A Pragmatic Definition of Therapeutic Synergy Suitable for Clinically Relevant In Vitro Multicompound Analyses

Kashif, Muhammad; Andersson, Claes; Åberg, Magnus; Nygren, Peter et al.

Ingår i Molecular Cancer Therapeutics, s. 1964-1976, 2014

• DOI för A Pragmatic Definition of Therapeutic Synergy Suitable for Clinically Relevant In Vitro Multicompound Analyses

Benchmarking of gastric cancer sensitivity to anti-cancer drugs ex vivo as a basis for drug selection in systemic and intraperitoneal therapy

Hultman, Bo; Mahteme, Haile; Sundbom, Magnus; Ljungman, Martin et al.

Ingår i Journal of Experimental & Clinical Cancer Research, 2014

• DOI för Benchmarking of gastric cancer sensitivity to anti-cancer drugs ex vivo as a basis for drug selection in systemic and intraperitoneal therapy
• Ladda ner fulltext (pdf) av Benchmarking of gastric cancer sensitivity to anti-cancer drugs ex vivo as a basis for drug selection in systemic and intraperitoneal therapy

Chemotherapeutic drug sensitivity of primary cultures of epithelial ovarian cancer cells from patients in relation to tumour characteristics and therapeutic outcome

von Heideman, Anne; Tholander, Bengt; Grundmark, Birgitta; Cajander, Stefan et al.

Ingår i Acta Oncologica, s. 242-250, 2014

• DOI för Chemotherapeutic drug sensitivity of primary cultures of epithelial ovarian cancer cells from patients in relation to tumour characteristics and therapeutic outcome

Effects of a dietary intervention on gastrointestinal symptoms after prostate cancer radiotherapy: Long-term results from a randomized controlled trial

Pettersson, Anna; Nygren, Peter; Persson, Christina; Berglund, Anders et al.

Ingår i Radiotherapy and Oncology, s. 240-247, 2014

• DOI för Effects of a dietary intervention on gastrointestinal symptoms after prostate cancer radiotherapy: Long-term results from a randomized controlled trial

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

Zhang, Xiaonan; Fryknäs, Mårten; Hernlund, Emma; Fayad, Walid et al.

Ingår i Nature Communications, s. 3295, 2014

• DOI för Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments
• Ladda ner fulltext (pdf) av Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

Zhang, Xiaonan; Fryknäs, Mårten; Hernlund, Emma; Fayad, Walid et al.

Ingår i Nature Communications, s. 3295, 2014

Repositioning of Quinacrine for Treatment of Acute Myeloid Leukemia

Eriksson, Anna; Osterros, Albin; Hassan, Sadia Bashir; Gullbo, Joachim et al.

Ingår i Blood, 2014

Safety and Preliminary Efficacy of Ultrasound-guided Percutaneous Irreversible Electroporation for Treatment of Localized Pancreatic Cancer

Månsson, Christopher; Bergenfeldt, Magnus; Brahmstaedt, Richard; Karlson, Britt-Marie et al.

Ingår i Anticancer Research, s. 289-293, 2014

Activity ex vivo of cytotoxic drugs in patient samples of peritoneal carcinomatosis with special focus on colorectal cancer

Cashin, Peter H; Mahteme, Haile; Graf, Wilhelm; Karlsson, Henning et al.

Ingår i BMC Cancer, s. 435, 2013

• DOI för Activity ex vivo of cytotoxic drugs in patient samples of peritoneal carcinomatosis with special focus on colorectal cancer
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Comparison of Prognostic Scores for Patients with Colorectal Cancer Peritoneal Metastases Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy

Cashin, Peter H.; Graf, Wilhelm; Nygren, Peter; Mahteme, Haile

Ingår i Annals of Surgical Oncology, s. 4183-4189, 2013

• DOI för Comparison of Prognostic Scores for Patients with Colorectal Cancer Peritoneal Metastases Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy

Internet-based stepped care with interactive support and cognitive behavioral therapy for reduction of anxiety and depressive symptoms in cancer: a clinical trial protocol

Mattsson, Susanne; Alfonsson, Sven; Carlsson, Maria; Nygren, Peter et al.

Ingår i BMC Cancer, s. 414, 2013

• DOI för Internet-based stepped care with interactive support and cognitive behavioral therapy for reduction of anxiety and depressive symptoms in cancer: a clinical trial protocol
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Pharmacokinetics of cisplatin during hyperthermic intraperitoneal treatment of peritoneal carcinomatosis

Cashin, Peter H; Ehrsson, H; Wallin, I; Nygren, Peter et al.

Ingår i European Journal of Clinical Pharmacology, s. 533-540, 2013

• DOI för Pharmacokinetics of cisplatin during hyperthermic intraperitoneal treatment of peritoneal carcinomatosis

Phase 1 clinical trials in end-stage cancer: patient understanding of trial premises and motives for participation

Godskesen, Tove; Nygren, Peter; Nordin, Karin; Hansson, Mats et al.

Ingår i Supportive Care in Cancer, s. 3137-3142, 2013

• DOI för Phase 1 clinical trials in end-stage cancer: patient understanding of trial premises and motives for participation

Phase II study of patients with peritoneal carcinomatosis from gastric cancer treated with preoperative systemic chemotherapy followed by peritonectomy and intraperitoneal chemotherapy

Hultman, Bo; Lind, Pehr; Glimelius, Bengt; Sundbom, Magnus et al.

Ingår i Acta Oncologica, s. 824-830, 2013

• DOI för Phase II study of patients with peritoneal carcinomatosis from gastric cancer treated with preoperative systemic chemotherapy followed by peritonectomy and intraperitoneal chemotherapy

Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells

Jarvius, Malin; Fryknäs, Mårten; D'Arcy, Padraig; Sun, Chao et al.

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 117-123, 2013

• DOI för Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells

Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer

Nygren, Peter; Fryknäs, Mårten; Anagel, Bengt; Larsson, Rolf

Ingår i Journal of Cancer Research and Clinical Oncology, s. 2133-2140, 2013

• DOI för Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer
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Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance

Fryknäs, Mårten; Gullbo, Joachim; Wang, Xin; Rickardson, Linda et al.

Ingår i BMC Cancer, s. 374, 2013

• DOI för Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance
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The Nanoparticulate Quillaja Saponin BBE Is Selectively Active Towards Renal Cell Carcinoma

Hassan, Saadia Bashir; Gullbo, Joachim; Hu, Kefei; Berenjian, Saideh et al.

Ingår i Anticancer Research, s. 143-151, 2013

Costs and clinical outcome of neoadjuvant systemic chemotherapy followed by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in peritoneal carcinomatosis from gastric cancer

Hultman, Bo; Lundkvist, Jonas; Glimelius, Bengt; Nygren, Peter et al.

Ingår i Acta Oncologica, s. 112-121, 2012

• DOI för Costs and clinical outcome of neoadjuvant systemic chemotherapy followed by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in peritoneal carcinomatosis from gastric cancer

Cytoreductive Surgery and Intraperitoneal Chemotherapy for Colorectal Peritoneal Carcinomatosis: Prognosis and Treatment of Recurrences in a Cohort Study

Cashin, Peter H; Graf, Wilhelm; Nygren, Peter; Mahteme, Haile

Ingår i European Journal of Surgical Oncology, s. 509-515, 2012

• DOI för Cytoreductive Surgery and Intraperitoneal Chemotherapy for Colorectal Peritoneal Carcinomatosis: Prognosis and Treatment of Recurrences in a Cohort Study
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Evaluation of predictive markers for patients with advanced colorectal cancer

Byström, Per; Berglund, Åke; Nygren, Peter; Wernroth, Lisa et al.

Ingår i Acta Oncologica, s. 849-859, 2012

• DOI för Evaluation of predictive markers for patients with advanced colorectal cancer

Histopathological Classification of Pseudomyxoma Peritonei and the Prognostic Importance of PINCH Protein

Andreasson, Håkan; Wanders, Alkwin; Sun, Xiao-Feng; Willén, Roger et al.

Ingår i Anticancer Research, s. 1443-1448, 2012

In vitro evaluation of clinical activity and toxicity of anticancer drugs using tumor cells from patients and cells representing normal tissues

Haglund, Caroline; Åleskog, Anna; Nygren, Peter; Gullbo, Joachim et al.

Ingår i Cancer Chemotherapy and Pharmacology, s. 697-707, 2012

• DOI för In vitro evaluation of clinical activity and toxicity of anticancer drugs using tumor cells from patients and cells representing normal tissues

Intraoperative hyperthermic versus postoperative normothermic intraperitoneal chemotherapy for colonic peritoneal carcinomatosis: a case-control study

Cashin, Peter H; Graf, Wilhelm; Nygren, Peter; Mahteme, Haile

Ingår i Annals of Oncology, s. 647-652, 2012

• DOI för Intraoperative hyperthermic versus postoperative normothermic intraperitoneal chemotherapy for colonic peritoneal carcinomatosis: a case-control study
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Loss of cancer drug activity in colon cancer HCT-116 cells during spheroid formation in a new 3-D spheroid cell culture system

Karlsson, Henning; Fryknäs, Mårten; Larsson, Rolf; Nygren, Peter

Ingår i Experimental Cell Research, s. 1577-1585, 2012

• DOI för Loss of cancer drug activity in colon cancer HCT-116 cells during spheroid formation in a new 3-D spheroid cell culture system

Outcome differences between debulking surgery and cytoreductive surgery in patients with pseudomyxoma peritonei

Andréasson, Håkan; Graf, Wilhelm; Nygren, Peter; Glimelius, Bengt et al.

Ingår i European Journal of Surgical Oncology, s. 962-968, 2012

• DOI för Outcome differences between debulking surgery and cytoreductive surgery in patients with pseudomyxoma peritonei

Patient Selection for Cytoreductive Surgery in Colorectal Peritoneal Carcinomatosis using Serum Tumour Markers – an Observational Cohort Study

Cashin, Peter H; Graf, Wilhelm; Nygren, Peter; Mahteme, Haile

Ingår i Annals of Surgery, s. 1078-1083, 2012

• DOI för Patient Selection for Cytoreductive Surgery in Colorectal Peritoneal Carcinomatosis using Serum Tumour Markers – an Observational Cohort Study

Pseudomyxoma Peritone: symptoms, treatment, prognosis and sensitivity to cytostatic drugs in vitro

Bjersand, Kathrine; Poromaa, Inger Sundström; Nygren, Peter; Mahteme, Haile

Ingår i Acta Obstetricia et Gynecologica Scandinavica, s. 71-71, 2012

• DOI för Pseudomyxoma Peritone: symptoms, treatment, prognosis and sensitivity to cytostatic drugs in vitro

Quantitative accuracy of parametric myocardial and tumour blood flow images based on HYPR-LR-filtered dynamic [O-15]water PET

Golla, Sandeep; Sörensen, Jens; Kero, Tanja; Harms, H. et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2012

Response to comments on 'Cytoreductive surgery and intraperitoneal chemotherapy'

Cashin, Peter H.; Graf, Wilhelm; Nygren, Peter; Mahteme, Haile

Ingår i European Journal of Surgical Oncology, s. 1012-1012, 2012

• DOI för Response to comments on 'Cytoreductive surgery and intraperitoneal chemotherapy'

The effect of a dimeric Affibody molecule (ZEGFR:1907)2 targeting EGFR in combination with radiation in colon cancer cell lines

Häggblad Sahlberg, Sara; Spiegelberg, Diana; Lennartsson, Johan; Nygren, Peter et al.

Ingår i International Journal of Oncology, s. 176-184, 2012

• DOI för The effect of a dimeric Affibody molecule (ZEGFR:1907)2 targeting EGFR in combination with radiation in colon cancer cell lines
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The initial change in tumor size predicts response and survival in patients with metastatic colorectal cancer treated with combination chemotherapy

Suzuki, C; Blomqvist, L; Sundin, Anders; Jacobsson, H et al.

Ingår i Annals of Oncology, s. 948-954, 2012

• DOI för The initial change in tumor size predicts response and survival in patients with metastatic colorectal cancer treated with combination chemotherapy

Aminopeptidase N (CD13) as a target for cancer chemotherapy

Wickström, Malin; Larsson, Rolf; Nygren, Peter; Gullbo, Joachim

Ingår i Cancer Science, s. 501-508, 2011

• DOI för Aminopeptidase N (CD13) as a target for cancer chemotherapy

Appendiceal Adenocarcinoids with Peritoneal Carcinomatosis Treated with Cytoreductive Surgery and Intraperitoneal Chemotherapy: a retrospective study of in vitro drug sensitivity and survival

Cashin, Peter; Nygren, Peter; Hellman, Per; Granberg, Dan et al.

Ingår i Clinical Colorectal Cancer, s. 108-112, 2011

• DOI för Appendiceal Adenocarcinoids with Peritoneal Carcinomatosis Treated with Cytoreductive Surgery and Intraperitoneal Chemotherapy: a retrospective study of in vitro drug sensitivity and survival

EGFR, HER2 and HER3 expression in primary colorectal carcinomas and corresponding metastases: Implications for targeted radionuclide therapy

Wei, Q.; Shui, Y.; Zheng, S.; Wester, Kenneth et al.

Ingår i Oncology Reports, s. 3-11, 2011

• DOI för EGFR, HER2 and HER3 expression in primary colorectal carcinomas and corresponding metastases: Implications for targeted radionuclide therapy

Novel activity of acriflavine against colorectal cancer tumor cells

Hassan, Saadia; Laryea, Daniel; Mahteme, Haile; Felth, Jenny et al.

Ingår i Cancer Science, s. 2206-2213, 2011

• DOI för Novel activity of acriflavine against colorectal cancer tumor cells