Åsa Johansson – Hur påverkar genetik och livsstil vår hälsa och sjukdomsrisk?
Runt en fjärdedel av befolkningen har någon gång drabbats av en vanlig folksjukdom. Syftet med vår forskning är att undersöka hur genetik och livsstil påverkar risken för olika sjukdomar, som hjärtkärlsjukdom och inflammatoriska sjukdomar, eller hur de påverkar vår fysiska och mentala hälsa
Under det senaste årtiondet har vi bidragit till att identifiera många gener som påverkar hälsan och risken för vanliga folksjukdomar. Trots denna framgång har bara en bråkdel av det genetiska bidraget till sjukdomar kartlagts. Inom vår forskning använder vi de nyaste teknologierna och analysmetoderna för att ytterligare öka kunskapen om de genetiska effekterna bakom våra folksjukdomar. Vi arbetar också med att skapa modeller för att identifiera individer med hög risk för olika sjukdomar.
Koppling mellan sjukdomsrisk och livsstilsfaktorer
Förutom att göra storskaliga genetiska undersökningar kartlägger vi också hur olika livsstilsfaktorer påverkar sjukdomsrisken, och hur detta kan mätas med olika molekylära teknologoer. Vi studerar hur livsstilsfaktorer integrerar med våra gener och hur effekterna skiljer sig åt mellan män och kvinnor.
Bland våra projekt ingår att undersöka hur övervikt och fettfördelning påverkar risken för cancer hos män och kvinnor med hjälp av olika avbildningsteknologier. Vi kartlägger även hur kvinnliga könshormoner, både sådana som bildas i kroppen och de som intas via preventivmedel eller hormonbehandling, påverkar risken för stroke, depression, skeletthälsa och reumatiska sjukdomar samt äggstocks-, endometrie- och bröstcancer.

Gruppmedlemmar
Publikationer
Ingår i The BMJ, 2024
- DOI för Contemporary menopausal hormone therapy and risk of cardiovascular disease - a Swedish nationwide register-based emulated target trial
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Genotyping oral contraceptive users for venous thromboembolism risk
Ingår i American Journal of Obstetrics and Gynecology, 2024
Ingår i Kidney international reports, s. 1849-1859, 2024
- DOI för Prioritization of Kidney Cell Types Highlights Myofibroblast Cells in Regulating Human Blood Pressure
- Ladda ner fulltext (pdf) av Prioritization of Kidney Cell Types Highlights Myofibroblast Cells in Regulating Human Blood Pressure
The genetic landscape of neuro-related proteins in human plasma
Ingår i Nature Human Behaviour, s. 2222-2234, 2024
Ingår i American Journal of Obstetrics and Gynecology, 2024
- DOI för The risk of venous thromboembolism in oral contraceptive users: the role of genetic factors-a prospective cohort study of 240,000 women in the UK Biobank
- Ladda ner fulltext (pdf) av The risk of venous thromboembolism in oral contraceptive users: the role of genetic factors-a prospective cohort study of 240,000 women in the UK Biobank
Adiposity and sex-specific cancer risk.
Ingår i Cancer Cell, s. 1186-11970000, 2023
- DOI för Adiposity and sex-specific cancer risk.
- Ladda ner fulltext (pdf) av Adiposity and sex-specific cancer risk.
An atlas of genetic scores to predict multi-omic traits
Ingår i Nature, s. 123-131, 2023
Ingår i Arthritis & Rheumatology, s. 2027-2035, 2023
- DOI för Body Mass Index and the Risk of Rheumatic Disease: Linear and Nonlinear Mendelian Randomization Analyses
- Ladda ner fulltext (pdf) av Body Mass Index and the Risk of Rheumatic Disease: Linear and Nonlinear Mendelian Randomization Analyses
Building a precision medicine infrastructure at a national level: The Swedish experience.
Ingår i Cambridge prisms. Precision medicine, 2023
Copy number variations and their effect on the plasma proteome
Ingår i Genetics, 2023
- DOI för Copy number variations and their effect on the plasma proteome
- Ladda ner fulltext (pdf) av Copy number variations and their effect on the plasma proteome
Ingår i Rheumatology, s. 2101-2108, 2023
- DOI för Effects of oral contraceptives and menopausal hormone therapy on the risk of rheumatoid arthritis: a prospective cohort study
- Ladda ner fulltext (pdf) av Effects of oral contraceptives and menopausal hormone therapy on the risk of rheumatoid arthritis: a prospective cohort study
Ingår i Forensic Science International, 2023
- DOI för Forensic prediction of sex, age, height, body mass index, hip-to-waist ratio, smoking status and lipid lowering drugs using epigenetic markers and plasma proteins
- Ladda ner fulltext (pdf) av Forensic prediction of sex, age, height, body mass index, hip-to-waist ratio, smoking status and lipid lowering drugs using epigenetic markers and plasma proteins
Genetic insights into resting heart rate and its role in cardiovascular disease
Ingår i Nature Communications, 2023
- DOI för Genetic insights into resting heart rate and its role in cardiovascular disease
- Ladda ner fulltext (pdf) av Genetic insights into resting heart rate and its role in cardiovascular disease
Ingår i Nature Immunology, s. 1540-1551, 2023
- DOI för Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets
- Ladda ner fulltext (pdf) av Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets
Illuminating the 'healthy obese' phenotype
Ingår i Nature Metabolism, s. 193-194, 2023
Polygenic risk scores and risk stratification in deep vein thrombosis.
Ingår i Thrombosis Research, s. 151-162, 2023
Population-based cohort study of oral contraceptive use and risk of depression
Ingår i Epidemiology and Psychiatric Sciences, 2023
- DOI för Population-based cohort study of oral contraceptive use and risk of depression
- Ladda ner fulltext (pdf) av Population-based cohort study of oral contraceptive use and risk of depression
Ingår i Journal of Internal Medicine, s. 378-396, 2023
- DOI för Precision medicine in complex diseases-Molecular subgrouping for improved prediction and treatment stratification.
- Ladda ner fulltext (pdf) av Precision medicine in complex diseases-Molecular subgrouping for improved prediction and treatment stratification.
A multi-omics study of circulating phospholipid markers of blood pressure
Ingår i Scientific Reports, 2022
- DOI för A multi-omics study of circulating phospholipid markers of blood pressure
- Ladda ner fulltext (pdf) av A multi-omics study of circulating phospholipid markers of blood pressure
Ingår i Nature Communications, 2022
- DOI för Contribution of rare whole-genome sequencing variants to plasma protein levels and the missing heritability
- Ladda ner fulltext (pdf) av Contribution of rare whole-genome sequencing variants to plasma protein levels and the missing heritability
Gene-based variant analysis of whole-exome sequencing in relation to eosinophil count
Ingår i Frontiers in Immunology, 2022
- DOI för Gene-based variant analysis of whole-exome sequencing in relation to eosinophil count
- Ladda ner fulltext (pdf) av Gene-based variant analysis of whole-exome sequencing in relation to eosinophil count
Genetic Landscape of the ACE2 Coronavirus Receptor
Ingår i Circulation, s. 1398-1411, 2022
- DOI för Genetic Landscape of the ACE2 Coronavirus Receptor
- Ladda ner fulltext (pdf) av Genetic Landscape of the ACE2 Coronavirus Receptor
Ingår i Nature Genetics, s. 1332-1344, 2022
- DOI för Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
- Ladda ner fulltext (pdf) av Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
Implementing precision medicine in a regionally organized healthcare system in Sweden.
Ingår i Nature Medicine, s. 1980-1982, 2022
Investigating the Effect of Estradiol Levels on the Risk of Breast, Endometrial, and Ovarian Cancer
Ingår i Journal of the Endocrine Society, 2022
- DOI för Investigating the Effect of Estradiol Levels on the Risk of Breast, Endometrial, and Ovarian Cancer
- Ladda ner fulltext (pdf) av Investigating the Effect of Estradiol Levels on the Risk of Breast, Endometrial, and Ovarian Cancer
Oral Contraceptives, Hormone Replacement Therapy, and Stroke Risk
Ingår i Stroke, s. 3107-3115, 2022
A combined genome-wide association and molecular study of age-related hearing loss in H. sapiens
Ingår i BMC Medicine, 2021
- DOI för A combined genome-wide association and molecular study of age-related hearing loss in H. sapiens
- Ladda ner fulltext (pdf) av A combined genome-wide association and molecular study of age-related hearing loss in H. sapiens
Causal effects of inflammatory protein biomarkers on inflammatory diseases
Ingår i Science Advances, 2021
- DOI för Causal effects of inflammatory protein biomarkers on inflammatory diseases
- Ladda ner fulltext (pdf) av Causal effects of inflammatory protein biomarkers on inflammatory diseases
Ingår i American Journal of Hematology, s. 1350-1362, 2021
- DOI för Characterization of the human ABO genotypes and their association to common inflammatory and cardiovascular diseases in the UK Biobank
- Ladda ner fulltext (pdf) av Characterization of the human ABO genotypes and their association to common inflammatory and cardiovascular diseases in the UK Biobank
DNA methylation in cord blood in association with prenatal depressive symptoms
Ingår i Clinical Epigenetics, 2021
- DOI för DNA methylation in cord blood in association with prenatal depressive symptoms
- Ladda ner fulltext (pdf) av DNA methylation in cord blood in association with prenatal depressive symptoms
Ingår i Journal of Clinical Endocrinology and Metabolism, 2021
- DOI för Genome-Wide Association Study of Estradiol Levels and the Causal Effect of Estradiol on Bone Mineral Density
- Ladda ner fulltext (pdf) av Genome-Wide Association Study of Estradiol Levels and the Causal Effect of Estradiol on Bone Mineral Density
Immune cells lacking Y chromosome show dysregulation of autosomal gene expression
Ingår i Cellular and Molecular Life Sciences (CMLS), s. 4019-4033, 2021
- DOI för Immune cells lacking Y chromosome show dysregulation of autosomal gene expression
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Ingår i Scientific Reports, 2021
- DOI för Inflammation-related plasma protein levels and association with adiposity measurements in young adults
- Ladda ner fulltext (pdf) av Inflammation-related plasma protein levels and association with adiposity measurements in young adults
Ingår i medRxiv : the preprint server for health sciences, s. 1-28, 2021
Ingår i American Journal of Psychiatry, s. 625-634, 2021
Technological readiness and implementation of genomic-driven precision medicine for complex diseases
Ingår i Journal of Internal Medicine, s. 602-620, 2021
- DOI för Technological readiness and implementation of genomic-driven precision medicine for complex diseases
- Ladda ner fulltext (pdf) av Technological readiness and implementation of genomic-driven precision medicine for complex diseases
Time-dependent effects of oral contraceptive use on breast, ovarian and endometrial cancers
Ingår i Cancer Research, s. 1153-1162, 2021
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals
Ingår i Nature Metabolism, s. 1135-1148, 2020
Associations of autozygosity with a broad range of human phenotypes
Ingår i Nature Communications, 2019
- DOI för Associations of autozygosity with a broad range of human phenotypes
- Ladda ner fulltext (pdf) av Associations of autozygosity with a broad range of human phenotypes
Ingår i Nature Medicine, s. 1390-1395, 2019
Epigenome-wide association study of lung function level and its change
Ingår i European Respiratory Journal, 2019
- DOI för Epigenome-wide association study of lung function level and its change
- Ladda ner fulltext (pdf) av Epigenome-wide association study of lung function level and its change
Ingår i Human Molecular Genetics, s. 4022-4041, 2019
- DOI för Genome-wide association analysis of 350 000 Caucasians from the UK Biobank identifies novel loci for asthma, hay fever and eczema
- Ladda ner fulltext (pdf) av Genome-wide association analysis of 350 000 Caucasians from the UK Biobank identifies novel loci for asthma, hay fever and eczema
Ingår i Nature Communications, 2019
- DOI för Genome-wide association study of body fat distribution identifies adiposity loci and sex-specific genetic effects
- Ladda ner fulltext (pdf) av Genome-wide association study of body fat distribution identifies adiposity loci and sex-specific genetic effects
Ingår i Scientific Reports, 2019
- DOI för Improved power and precision with whole genome sequencing data in genome-wide association studies of inflammatory biomarkers
- Ladda ner fulltext (pdf) av Improved power and precision with whole genome sequencing data in genome-wide association studies of inflammatory biomarkers
Ingår i Frontiers in Genetics, 2018
- DOI för A Meta-Analysis of Genome-Wide Association Studies of Growth Differentiation Factor-15 Concentration in Blood
- Ladda ner fulltext (pdf) av A Meta-Analysis of Genome-Wide Association Studies of Growth Differentiation Factor-15 Concentration in Blood
Breast-feeding and risk of asthma, hay fever, and eczema
Ingår i Journal of Allergy and Clinical Immunology, s. 1157-+, 2018
Ingår i Nature Genetics, s. 1412-1425, 2018
Genetic variants influencing phenotypic variance heterogeneity
Ingår i Human Molecular Genetics, s. 799-810, 2018
Meta-analysis of exome array data identifies six novel genetic loci for lung function.
Ingår i Wellcome open research, 2018
Ingår i Scientific Reports, 2018
- DOI för Systemic and specific effects of antihypertensive and lipid-lowering medication on plasma protein biomarkers for cardiovascular diseases
- Ladda ner fulltext (pdf) av Systemic and specific effects of antihypertensive and lipid-lowering medication on plasma protein biomarkers for cardiovascular diseases
1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.
Ingår i Scientific Reports, 2017
- DOI för 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.
- Ladda ner fulltext (pdf) av 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.
Epigenome-wide DNA methylation study of IgE concentration in relation to self-reported allergies
Ingår i Epigenomics, s. 407-418, 2017
Ingår i PLOS Genetics, 2017
- DOI för Gene-environment interaction study for BMI reveals interactions between genetic factors and physical activity, alcohol consumption and socioeconomic status.
- Ladda ner fulltext (pdf) av Gene-environment interaction study for BMI reveals interactions between genetic factors and physical activity, alcohol consumption and socioeconomic status.
Ingår i Nature Genetics, s. 403-415, 2017
Genome-wide physical activity interactions in adiposity: A meta-analysis of 200,452 adults.
Ingår i PLOS Genetics, 2017
- DOI för Genome-wide physical activity interactions in adiposity: A meta-analysis of 200,452 adults.
- Ladda ner fulltext (pdf) av Genome-wide physical activity interactions in adiposity: A meta-analysis of 200,452 adults.
Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease
Ingår i PLOS Genetics, 2017
- DOI för Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease
- Ladda ner fulltext (pdf) av Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease
Ingår i Hypertension, 2017
Ingår i European Journal of Human Genetics, s. 1253-1260, 2017
- DOI för SweGen: a whole-genome data resource of genetic variability in a cross-section of the Swedish population
- Ladda ner fulltext (pdf) av SweGen: a whole-genome data resource of genetic variability in a cross-section of the Swedish population
Tea and coffee consumption in relation to DNA methylation in four European cohorts
Ingår i Human Molecular Genetics, s. 3221-3231, 2017
Ingår i PLOS Genetics, 2017
- DOI för The relative contribution of DNA methylation and genetic variants on protein biomarkers for human diseases.
- Ladda ner fulltext (pdf) av The relative contribution of DNA methylation and genetic variants on protein biomarkers for human diseases.
A multiple-phenotype imputation method for genetic studies
Ingår i Nature Genetics, s. 466-472, 2016
Ingår i Human Molecular Genetics, s. 4739-4748, 2016
Ingår i Nature Communications, 2016
- DOI för Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
- Ladda ner fulltext (pdf) av Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Ingår i Human Molecular Genetics, s. 1447-1456, 2016
Ingår i Human Molecular Genetics, s. 817-827, 2016
Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 14372-14377, 2016
Ingår i Epigenomics, s. 5-7, 2016
Directional dominance on stature and cognition in diverse human populations
Ingår i Nature, s. 459-462, 2015
Ingår i Biomarkers, s. 355-364, 2015
Effect of genetic variations on ticagrelor plasma levels and clinical outcomes
Ingår i European Heart Journal, s. 1901-1912, 2015
Genetic studies of body mass index yield new insights for obesity biology
Ingår i Nature, s. 197-206, 2015
Ingår i PLOS ONE, 2015
- DOI för Genome-Wide Association Study Identifies That the ABO Blood Group System Influences Interleukin-10 Levels and the Risk of Clinical Events in Patients with Acute Coronary Syndrome
- Ladda ner fulltext (pdf) av Genome-Wide Association Study Identifies That the ABO Blood Group System Influences Interleukin-10 Levels and the Risk of Clinical Events in Patients with Acute Coronary Syndrome
Homozygous loss-of-function variants in European cosmopolitan and isolate populations
Ingår i Human Molecular Genetics, s. 5464-5475, 2015
- DOI för Homozygous loss-of-function variants in European cosmopolitan and isolate populations
- Ladda ner fulltext (pdf) av Homozygous loss-of-function variants in European cosmopolitan and isolate populations
Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans
Ingår i PLOS ONE, 2015
- DOI för Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans
- Ladda ner fulltext (pdf) av Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans
Ingår i Circulation, s. 498-506, 2015
Protein profiling reveals consequences of lifestyle choices on predicted biological aging
Ingår i Scientific Reports, 2015
Protein profiling reveals consequences of lifestyle choices on predicted biological aging
Ingår i Scientific Reports, 2015
Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
Ingår i Nature Communications, 2015
- DOI för Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
- Ladda ner fulltext (pdf) av Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
Ingår i PLOS Genetics, 2015
- DOI för The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
- Ladda ner fulltext (pdf) av The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
Ingår i Nature Genetics, s. 1173-1186, 2014
Genome-wide association analysis identifies six new loci associated with forced vital capacity
Ingår i Nature Genetics, s. 669-677, 2014
Ingår i American Heart Journal, s. 96-102, 2014
Smoke-related DNA methylation changes in the etiology of human disease
Ingår i Human Molecular Genetics, s. 2290-2297, 2014
Ingår i Nature Communications, s. 4684, 2014
Ingår i International Journal of Circumpolar Health, s. 421-427, 2013
- DOI för Animal source food intake and association with blood cholesterol, glycerophospholipids and sphingolipids in a northern Swedish population
- Ladda ner fulltext (pdf) av Animal source food intake and association with blood cholesterol, glycerophospholipids and sphingolipids in a northern Swedish population
Ingår i Circulation, 2013
Ingår i International Journal of Circumpolar Health, s. 516-517, 2013
Common variants associated with plasma triglycerides and risk for coronary artery disease
Ingår i Nature Genetics, s. 1345-+, 2013
Common Variants in Mendelian Kidney Disease Genes and Their Association with Renal Function
Ingår i Journal of the American Society of Nephrology, s. 2105-2117, 2013
Continuous Aging of the Human DNA Methylome Throughout the Human Lifespan
Ingår i PLOS ONE, 2013
- DOI för Continuous Aging of the Human DNA Methylome Throughout the Human Lifespan
- Ladda ner fulltext (pdf) av Continuous Aging of the Human DNA Methylome Throughout the Human Lifespan
Ingår i PLOS ONE, 2013
- DOI för Differential Gene Expression at the Maternal-Fetal Interface in Preeclampsia Is Influenced by Gestational Age
- Ladda ner fulltext (pdf) av Differential Gene Expression at the Maternal-Fetal Interface in Preeclampsia Is Influenced by Gestational Age
Discovery and refinement of loci associated with lipid levels
Ingår i Nature Genetics, s. 1274-1283, 2013
Ingår i Circulation, 2013
Ingår i Circulation, 2013
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
Ingår i Nature Genetics, s. 145-154, 2013
Ingår i Nature Genetics, s. 501-U69, 2013
- DOI för Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
- Ladda ner fulltext (pdf) av Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Identification of genetic variants influencing the human plasma proteome
Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 4673-4678, 2013
Ingår i Nature Genetics, s. 621-+, 2013
Large-scale association analysis identifies new risk loci for coronary artery disease
Ingår i Nature Genetics, s. 25-33, 2013
Ingår i International Journal of Circumpolar Health, s. 511-512, 2013