Anna Dimberg – Hur kan blodkärlen påverka tumörens tillväxt och svar på behandling?

Lack of ST2 aggravates glioma invasiveness, vascular abnormality, and immune suppression

Wicher, Grzegorz; Roy, Ananya; Vaccaro, Alessandra; Vemuri, Kalyani et al.

Ingår i Neuro-Oncology Advances, 2025

• DOI för Lack of ST2 aggravates glioma invasiveness, vascular abnormality, and immune suppression
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Trogocytosis of chimeric antigen receptors between T cells is regulated by their transmembrane domains

Barbera, Stefano; Schuiling, Matthijs J. A.; Sanjaya, Nathaniel A.; Pietilä, Ilkka et al.

Ingår i Science immunology, 2025

• DOI för Trogocytosis of chimeric antigen receptors between T cells is regulated by their transmembrane domains

CD93 maintains endothelial barrier function and limits metastatic dissemination

Vemuri, Kalyani; de Alves Pereira, Beatriz; Fuenzalida, Patricia; Subashi, Yelin et al.

Ingår i JCI Insight, 2024

• DOI för CD93 maintains endothelial barrier function and limits metastatic dissemination
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Single-cell dissection of the human blood-brain barrier and glioma blood-tumor barrier

Xie, Yuan; Yang, Fan; He, Liqun; Huang, Hua et al.

Ingår i Neuron, 2024

• DOI för Single-cell dissection of the human blood-brain barrier and glioma blood-tumor barrier

Vascular characterization reveals immunomodulatory targets for brain metastases

Lugano, Roberta; Dimberg, Anna

Ingår i Cancer Cell, s. 328-330, 2024

• DOI för Vascular characterization reveals immunomodulatory targets for brain metastases

VLDLR mediates Semliki Forest virus neuroinvasion through the blood-cerebrospinal fluid barrier

Martikainen, Miika; Lugano, Roberta; Pietilä, Ilkka; Brosch, Sofie et al.

Ingår i Nature Communications, 2024

• DOI för VLDLR mediates Semliki Forest virus neuroinvasion through the blood-cerebrospinal fluid barrier
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CD93 maintains endothelial barrier function by limiting the phosphorylation and turnover of VE-cadherin

Lugano, Roberta; Vemuri, Kalyani; Barbera, Stefano; Orlandini, Maurizio et al.

Ingår i The FASEB Journal, 2023

• DOI för CD93 maintains endothelial barrier function by limiting the phosphorylation and turnover of VE-cadherin
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Complementarity-determining region clustering may cause CAR-T cell dysfunction

Sarén, Tina; Saronio, Giulia; Marti Torrell, Paula; Zhu, Xu et al.

Ingår i Nature Communications, 2023

• DOI för Complementarity-determining region clustering may cause CAR-T cell dysfunction
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Dimerization of the C-type lectin-like receptor CD93 promotes its binding to Multimerin-2 in endothelial cells

Barbera, Stefano; Raucci, Luisa; Tassone, Giusy; Tinti, Laura et al.

Ingår i International Journal of Biological Macromolecules, s. 453-464, 2023

• DOI för Dimerization of the C-type lectin-like receptor CD93 promotes its binding to Multimerin-2 in endothelial cells
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Editorial: The blood-brain barrier in brain tumors: molecular mechanisms and therapeutic strategies

Zhang, Lei; Dimberg, Anna; Rasouli, Javad

Ingår i Frontiers in Neurology, 2023

• DOI för Editorial: The blood-brain barrier in brain tumors: molecular mechanisms and therapeutic strategies
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Endothelial VEGFR2-PLCγ signaling regulates vascular permeability and antitumor immunity through eNOS/Src

Sjöberg, Elin; Melssen, Marit; Richards, Mark; Ding, Yindi et al.

Ingår i Journal of Clinical Investigation, 2023

• DOI för Endothelial VEGFR2-PLCγ signaling regulates vascular permeability and antitumor immunity through eNOS/Src
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Of mice and lymphoid aggregates: modeling tertiary lymphoid structures in cancer

Vaccaro, Alessandra; van de Walle, Tiarne; Ramachandran, Mohanraj; Essand, Magnus et al.

Ingår i Frontiers in Immunology, 2023

• DOI för Of mice and lymphoid aggregates: modeling tertiary lymphoid structures in cancer
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Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma

Ramachandran, Mohanraj; Vaccaro, Alessandra; van de Walle, Tiarne; Georganaki, Maria et al.

Ingår i Cancer Cell, s. 1134-1151, 2023

• DOI för Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma
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Wnt signaling regulates MFSD2A-dependent drug delivery through endothelial transcytosis in glioma

Xie, Yuan; He, Liqun; Zhang, Yanyu; Huang, Hua et al.

Ingår i Neuro-Oncology, s. 1073-1084, 2023

• DOI för Wnt signaling regulates MFSD2A-dependent drug delivery through endothelial transcytosis in glioma

A method for Boolean analysis of protein interactions at a molecular level

Raykova, Doroteya; Kermpatsou, Despoina; Malmqvist, Tony; Harrison, Philip J et al.

Ingår i Nature Communications, 2022

• DOI för A method for Boolean analysis of protein interactions at a molecular level
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Tertiary Lymphoid Structures: From Basic Biology to Translational Impact in Cancer. Editorial

Sautes-Fridman, Catherine; Dimberg, Anna; Verma, Vivek

Ingår i Frontiers in Immunology, 2022

• DOI för Tertiary Lymphoid Structures: From Basic Biology to Translational Impact in Cancer. Editorial
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Vaccination against galectin-1 promotes cytotoxic T-cell infiltration in melanoma and reduces tumor burden

Femel, Julia; van Hooren, Luuk; Herre, Melanie; Cedervall, Jessica et al.

Ingår i Cancer Immunology and Immunotherapy, s. 2029-2040, 2022

• DOI för Vaccination against galectin-1 promotes cytotoxic T-cell infiltration in melanoma and reduces tumor burden
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1p/19q co-deletion status is associated with distinct tumor-associated macrophage infiltration in IDH mutated lower-grade gliomas

Zhang, Yanyu; Xie, Yuan; He, Liqun; Tang, Jiefu et al.

Ingår i Cellular Oncology, s. 193-204, 2021

• DOI för 1p/19q co-deletion status is associated with distinct tumor-associated macrophage infiltration in IDH mutated lower-grade gliomas

Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma

van Hooren, Luuk; Vaccaro, Alessandra; Ramachandran, Mohanraj; Vazaios, Konstantinos et al.

Ingår i Nature Communications, 2021

• DOI för Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma
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Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy

Sun, Yi; Chen, Wei; Torphy, Robert J.; Yao, Sheng et al.

Ingår i Science Translational Medicine, 2021

• DOI för Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy

CD93 Signaling via Rho Proteins Drives Cytoskeletal Remodeling in Spreading Endothelial Cells

Barbera, Stefano; Raucci, Luisa; Lugano, Roberta; Tosi, Gian Marco et al.

Ingår i International Journal of Molecular Sciences, 2021

• DOI för CD93 Signaling via Rho Proteins Drives Cytoskeletal Remodeling in Spreading Endothelial Cells
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Deletions on Chromosome Y and Downregulation of the SRY Gene in Tumor Tissue Are Associated with Worse Survival of Glioblastoma Patients

Łysiak, Małgorzata; Smits, Anja; Roodakker, Kenney Roy; Sandberg, Elisabeth et al.

Ingår i Cancers, 2021

• DOI för Deletions on Chromosome Y and Downregulation of the SRY Gene in Tumor Tissue Are Associated with Worse Survival of Glioblastoma Patients
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ELTD1-deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma.

Huang, Hua; Georganaki, Maria; Conze, Lei Liu; Laviña, Bàrbara et al.

Ingår i Neuro-Oncology, s. 398-411, 2021

• DOI för ELTD1-deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma.
• Ladda ner fulltext (pdf) av ELTD1-deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma.

IFN-I-tolerant oncolytic Semliki Forest virus in combination with anti-PD1 enhances T cell response against mouse glioma

Martikainen, Miika; Ramachandran, Mohanraj; Lugano, Roberta; Ma, Jing et al.

Ingår i MOLECULAR THERAPY-ONCOLYTICS, s. 37-46, 2021

• DOI för IFN-I-tolerant oncolytic Semliki Forest virus in combination with anti-PD1 enhances T cell response against mouse glioma
• Ladda ner fulltext (pdf) av IFN-I-tolerant oncolytic Semliki Forest virus in combination with anti-PD1 enhances T cell response against mouse glioma

Key molecular alterations in endothelial cells in human glioblastoma uncovered through single-cell RNA sequencing

Xie, Yuan; He, Liqun; Lugano, Roberta; Zhang, Yanyu et al.

Ingår i JCI Insight, 2021

• DOI för Key molecular alterations in endothelial cells in human glioblastoma uncovered through single-cell RNA sequencing
• Ladda ner fulltext (pdf) av Key molecular alterations in endothelial cells in human glioblastoma uncovered through single-cell RNA sequencing

The C-type lectin CD93 controls endothelial cell migration via activation of the Rho family of small GTPases

Barbera, Stefano; Lugano, Roberta; Pedalina, Alessia; Mongiat, Maurizio et al.

Ingår i Matrix Biology, s. 1-17, 2021

• DOI för The C-type lectin CD93 controls endothelial cell migration via activation of the Rho family of small GTPases

Fgfbp1 promotes blood-brain barrier development by regulating collagen IV deposition and maintaining Wnt/beta-catenin signaling

Cottarelli, Azzurra; Corada, Monica; Beznoussenko, Galina, V; Mironov, Alexander A. et al.

Ingår i Development, 2020

• DOI för Fgfbp1 promotes blood-brain barrier development by regulating collagen IV deposition and maintaining Wnt/beta-catenin signaling

Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis

Zhang, Yanyu; Cedervall, Jessica; Hamidi, Anahita; Herre, Melanie et al.

Ingår i Cancer Research, s. 3345-3358, 2020

• DOI för Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis

The Binding of CD93 to Multimerin-2 Promotes Choroidal Neovascularization

Tosi, Gian Marco; Neri, Giovanni; Barbera, Stefano; Mundo, Lucia et al.

Ingår i Investigative Ophthalmology and Visual Science, 2020

• DOI för The Binding of CD93 to Multimerin-2 Promotes Choroidal Neovascularization
• Ladda ner fulltext (pdf) av The Binding of CD93 to Multimerin-2 Promotes Choroidal Neovascularization

Tumor angiogenesis: causes, consequences, challenges and opportunities

Lugano, Roberta; Ramachandran, Mohanraj; Dimberg, Anna

Ingår i Cellular and Molecular Life Sciences (CMLS), s. 1745-1770, 2020

• DOI för Tumor angiogenesis: causes, consequences, challenges and opportunities
• Ladda ner fulltext (pdf) av Tumor angiogenesis: causes, consequences, challenges and opportunities

Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy

Georganaki, Maria; Ramachandran, Mohanraj; Tuit, Sander; Nunez, Nicolas Gonzalo et al.

Ingår i Oncoimmunology, 2020

• DOI för Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy
• Ladda ner fulltext (pdf) av Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy

Tumor endothelial ELTD1 as a predictive marker for treatment of renal cancer patients with sunitinib

Niinivirta, Marjut; Georganaki, Maria; Enblad, Gunilla; Lindskog, Cecilia et al.

Ingår i BMC Cancer, 2020

• DOI för Tumor endothelial ELTD1 as a predictive marker for treatment of renal cancer patients with sunitinib
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Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation

Arce, Maximiliano; Pinto, Mauricio P.; Galleguillos, Macarena; Munoz, Catalina et al.

Ingår i Cancers, 2019

• DOI för Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation
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Region-by-region analysis of PET, MRI, and histology in en bloc-resected oligodendrogliomas reveals intra-tumoral heterogeneity

Roodakker, Kenney Roy; Alhuseinalkhudhur, Ali; Al-Jaff, Mohammed; Georganaki, Maria et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 569-579, 2019

• DOI för Region-by-region analysis of PET, MRI, and histology in en bloc-resected oligodendrogliomas reveals intra-tumoral heterogeneity

The small GTPase Rab5c is a key regulator of trafficking of the CD93/Multimerin-2/1 integrin complex in endothelial cell adhesion and migration

Barbera, Stefano; Nardi, Federica; Elia, Ines; Realini, Giulia et al.

Ingår i Cell Communication and Signaling, 2019

• DOI för The small GTPase Rab5c is a key regulator of trafficking of the CD93/Multimerin-2/1 integrin complex in endothelial cell adhesion and migration
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Bones in human CYP26B1 deficiency and rats with hypervitaminosis A phenocopy Vegfa overexpression

Lind, Thomas; Lugano, Roberta; Gustafson, Ann-Marie; Norgård, Maria et al.

Ingår i Bone Reports, s. 27-36, 2018

• DOI för Bones in human CYP26B1 deficiency and rats with hypervitaminosis A phenocopy Vegfa overexpression
• Ladda ner fulltext (pdf) av Bones in human CYP26B1 deficiency and rats with hypervitaminosis A phenocopy Vegfa overexpression

CD93 promotes β1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis

Lugano, Roberta; Vemuri, Kalyani; Yu, Di; Bergqvist, Michael et al.

Ingår i Journal of Clinical Investigation, s. 3280-3297, 2018

• DOI för CD93 promotes β1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis
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Consensus guidelines for the use and interpretation of angiogenesis assays

Nowak-Sliwinska, Patrycja; Alitalo, Kari; Allen, Elizabeth; Anisimov, Andrey et al.

Ingår i Angiogenesis, s. 425-532, 2018

• DOI för Consensus guidelines for the use and interpretation of angiogenesis assays
• Ladda ner fulltext (pdf) av Consensus guidelines for the use and interpretation of angiogenesis assays

IDH mutation status is associated with distinct vascular gene expression signatures in lower-grade gliomas

Zhang, Lei; He, Liqun; Lugano, Roberta; Roodakker, Kenney Roy et al.

Ingår i Neuro-Oncology, s. 1505-1516, 2018

• DOI för IDH mutation status is associated with distinct vascular gene expression signatures in lower-grade gliomas
• Ladda ner fulltext (pdf) av IDH mutation status is associated with distinct vascular gene expression signatures in lower-grade gliomas

Osteoglycin - A switch from angiogenesis to T-cell recruitment?

Dimberg, Anna

Ingår i EBioMedicine, s. 22-23, 2018

• DOI för Osteoglycin - A switch from angiogenesis to T-cell recruitment?
• Ladda ner fulltext (pdf) av Osteoglycin - A switch from angiogenesis to T-cell recruitment?

Vascular Targeting to Increase the Efficiency of Immune Checkpoint Blockade in Cancer

Georganaki, Maria; van Hooren, Luuk; Dimberg, Anna

Ingår i Frontiers in Immunology, 2018

• DOI för Vascular Targeting to Increase the Efficiency of Immune Checkpoint Blockade in Cancer
• Ladda ner fulltext (pdf) av Vascular Targeting to Increase the Efficiency of Immune Checkpoint Blockade in Cancer

Activating CD40 While Inhibiting IL6R Induces Cytokine Production without PDL1 Upregulation in DCs

Eriksson, Emma; Milenova, Ioanna; Wenthe, Jessica; Moreno, Rafael et al.

Ingår i Molecular Therapy, s. 54-54, 2017

Activation of myeloid and endothelial cells by CD40L gene therapy supports T-cell expansion and migration into the tumor microenvironment

Eriksson, Emma; Moreno, R; Milenova, I. Yoanna; Liljenfeldt, L et al.

Ingår i Gene Therapy, s. 92-103, 2017

• DOI för Activation of myeloid and endothelial cells by CD40L gene therapy supports T-cell expansion and migration into the tumor microenvironment
• Ladda ner fulltext (pdf) av Activation of myeloid and endothelial cells by CD40L gene therapy supports T-cell expansion and migration into the tumor microenvironment

Local checkpoint inhibition of CTLA-4 as a monotherapy or in combination with anti-PD1 prevents the growth of murine bladder cancer

van Hooren, Luuk; Sandin, Linda C.; Moskalev, Igor; Ellmark, Peter et al.

Ingår i European Journal of Immunology, s. 385-393, 2017

• DOI för Local checkpoint inhibition of CTLA-4 as a monotherapy or in combination with anti-PD1 prevents the growth of murine bladder cancer

Pharmacological targeting of peptidylarginine deiminase 4 prevents cancer-associated kidney injury in mice.

Cedervall, Jessica; Dragomir, Anca; Saupe, Falk; Zhang, Yanyu et al.

Ingår i Oncoimmunology, 2017

• DOI för Pharmacological targeting of peptidylarginine deiminase 4 prevents cancer-associated kidney injury in mice.

Safe and effective treatment of experimental neuroblastoma and glioblastoma using systemically administered triple microRNA-detargeted oncolytic Semliki Forest virus

Ramachandran, Mohanraj; Yu, Di; Dyczynski, Matheus; Baskaran, Sathishkumar et al.

Ingår i Clinical Cancer Research, s. 1519-1530, 2017

• DOI för Safe and effective treatment of experimental neuroblastoma and glioblastoma using systemically administered triple microRNA-detargeted oncolytic Semliki Forest virus

Shaping the Tumor Stroma and Sparking Immune Activation by CD40 and 4-1BB Signaling Induced by an Armed Oncolytic Virus.

Svensson, Emma; Milenova, Ioanna; Wenthe, Jessica; Ståhle, Magnus et al.

Ingår i Clinical Cancer Research, s. 5846-5857, 2017

• DOI för Shaping the Tumor Stroma and Sparking Immune Activation by CD40 and 4-1BB Signaling Induced by an Armed Oncolytic Virus.

The cancer-immunity cycle as rational design for synthetic cancer drugs: Novel DC vaccines and CAR T-cells

Ramachandran, Mohanraj; Dimberg, Anna; Essand, Magnus

Ingår i Seminars in Cancer Biology, s. 23-35, 2017

• DOI för The cancer-immunity cycle as rational design for synthetic cancer drugs: Novel DC vaccines and CAR T-cells
• Ladda ner fulltext (pdf) av The cancer-immunity cycle as rational design for synthetic cancer drugs: Novel DC vaccines and CAR T-cells

ANLN is a prognostic biomarker independent of Ki-67 and essential for cell cycle progression in primary breast cancer

Magnusson, Kristina; Gremel, Gabriela; Rydén, Lisa; Pontén, Victor et al.

Ingår i BMC Cancer, 2016

• DOI för ANLN is a prognostic biomarker independent of Ki-67 and essential for cell cycle progression in primary breast cancer
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Heparanase Promotes Glioma Progression and is Inversely Correlated with Patient Survival.

Kundu, Soumi; Xiong, Anqi; Spyrou, Argyris; Wicher, Grzegorz et al.

Ingår i Molecular Cancer Research, s. 1243-1253, 2016

• DOI för Heparanase Promotes Glioma Progression and is Inversely Correlated with Patient Survival.

Pleiotrophin enhances PDGFB-induced gliomagenesis through increased proliferation of neural progenitor cells

Zhang, Lei; Laaniste, Liisi; Jiang, Yiwen; Alafuzoff, Irina et al.

Ingår i Oncotarget, s. 80382-80390, 2016

• DOI för Pleiotrophin enhances PDGFB-induced gliomagenesis through increased proliferation of neural progenitor cells
• Ladda ner fulltext (pdf) av Pleiotrophin enhances PDGFB-induced gliomagenesis through increased proliferation of neural progenitor cells

Pleiotrophin is a driver of vascular abnormalization in glioblastoma

Zhang, Lei; Dimberg, Anna

Ingår i Molecular & Cellular Oncology, 2016

• DOI för Pleiotrophin is a driver of vascular abnormalization in glioblastoma

Sunitinib enhances the antitumor responses of agonistic CD40-antibody by reducing MDSCs and synergistically improving endothelial activation and T-cell recruitment

van Hooren, Luuk; Georganaki, Maria; Huang, Hua; Mangsbo, Sara M. et al.

Ingår i Oncotarget, s. 50277-50289, 2016

• DOI för Sunitinib enhances the antitumor responses of agonistic CD40-antibody by reducing MDSCs and synergistically improving endothelial activation and T-cell recruitment
• Ladda ner fulltext (pdf) av Sunitinib enhances the antitumor responses of agonistic CD40-antibody by reducing MDSCs and synergistically improving endothelial activation and T-cell recruitment

Tumor-induced neutrophil extracellular traps-drivers of systemic inflammation and vascular dysfunction

Cedervall, Jessica; Dimberg, Anna; Olsson, Anna-Karin

Ingår i Oncoimmunology, 2016

• DOI för Tumor-induced neutrophil extracellular traps-drivers of systemic inflammation and vascular dysfunction

Elevated Expression of the C-Type Lectin CD93 in the Glioblastoma Vasculature Regulates Cytoskeletal Rearrangements That Enhance Vessel Function and Reduce Host Survival

Langenkamp, Elise; Zhang, Lei; Lugano, Roberta; Huang, Hua et al.

Ingår i Cancer Research, s. 4504-4516, 2015

• DOI för Elevated Expression of the C-Type Lectin CD93 in the Glioblastoma Vasculature Regulates Cytoskeletal Rearrangements That Enhance Vessel Function and Reduce Host Survival

Neutrophil Extracellular Traps Accumulate in Peripheral Blood Vessels and Compromise Organ Function in Tumor-Bearing Animals

Cedervall, Jessica; Zhang, Yanyu; Huang, Hua; Zhang, Lei et al.

Ingår i Cancer Research, s. 2653-2662, 2015

• DOI för Neutrophil Extracellular Traps Accumulate in Peripheral Blood Vessels and Compromise Organ Function in Tumor-Bearing Animals

Next-Generation Pathology: Surveillance of Tumor Microecology

Koos, Björn; Kamali-Moghaddam, Masood; David, Leonor; Sobrinho-Simoes, Manuel et al.

Ingår i Journal of Molecular Biology, s. 2013-2022, 2015

• DOI för Next-Generation Pathology: Surveillance of Tumor Microecology

Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas.

Zhang, Lei; Kundu, Soumi; Feenstra, Tjerk; Li, Xiujuan et al.

Ingår i Science Signaling, 2015

• DOI för Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas.

Tumor-Induced Local and Systemic Impact on Blood Vessel Function

Cedervall, Jessica; Dimberg, Anna; Olsson, Anna-Karin

Ingår i Mediators of Inflammation, 2015

• DOI för Tumor-Induced Local and Systemic Impact on Blood Vessel Function
• Ladda ner fulltext (pdf) av Tumor-Induced Local and Systemic Impact on Blood Vessel Function

VEGF suppresses T-lymphocyte infiltration in the tumor microenvironment through inhibition of NF-κB-induced endothelial activation

Huang, Hua; Langenkamp, Elise; Georganaki, Maria; Loskog, Angelica et al.

Ingår i The FASEB Journal, s. 227-238, 2015

• DOI för VEGF suppresses T-lymphocyte infiltration in the tumor microenvironment through inhibition of NF-κB-induced endothelial activation

CD40L gene therapy tilts the myeloid cell profile and promotes infiltration of activated T lymphocytes

Liljenfeldt, Lina; Dieterich, Lothar C.; Dimberg, Anna; Mangsbo, Sara M. et al.

Ingår i Cancer Gene Therapy, s. 95-102, 2014

• DOI för CD40L gene therapy tilts the myeloid cell profile and promotes infiltration of activated T lymphocytes

Progression of metastatic breast cancer can be attenuated by therapeutic vaccination against the tumor vascular marker ED-A

Femel, Julia; Huijbers, Elisabeth J. M.; Saupe, Falk; Cedervall, Jessica et al.

Ingår i Angiogenesis, s. 769-769, 2014

Subtyping of gliomas of various WHO grades by the application of immunohistochemistry

Popova, Svetlana N; Bergqvist, Michael; Dimberg, Anna; Edqvist, Per-Henrik et al.

Ingår i Histopathology, s. 365-379, 2014

• DOI för Subtyping of gliomas of various WHO grades by the application of immunohistochemistry

The glioblastoma vasculature as a target for cancer therapy

Dimberg, Anna

Ingår i Biochemical Society Transactions, s. 1647-1652, 2014

• DOI för The glioblastoma vasculature as a target for cancer therapy

Therapeutic vaccination against fibronectin ED-A attenuates progression of metastatic breast cancer.

Femel, Julia; Huijbers, Elisabeth JM; Saupe, Falk; Cedervall, Jessica et al.

Ingår i Oncotarget, s. 12418-12427, 2014

• Ladda ner fulltext (pdf) av Therapeutic vaccination against fibronectin ED-A attenuates progression of metastatic breast cancer.

alpha B-Crystallin regulates expansion of CD11b(+)Gr-1(+) immature myeloid cells during tumor progression

Dieterich, Lothar C; Schiller, Petter; Huang, Hua; Wawrousek, Eric F et al.

Ingår i The FASEB Journal, s. 151-162, 2013

• DOI för alpha B-Crystallin regulates expansion of CD11b(+)Gr-1(+) immature myeloid cells during tumor progression

alpha B-crystallin/HspB5 regulates endothelial-leukocyte interactions by enhancing NF-kappa B-induced up-regulation of adhesion molecules ICAM-1, VCAM-1 and E-selectin

Dieterich, Lothar C.; Huang, Hua; Massena, Sara; Golenhofen, Nikola et al.

Ingår i Angiogenesis, s. 975-983, 2013

• DOI för alpha B-crystallin/HspB5 regulates endothelial-leukocyte interactions by enhancing NF-kappa B-induced up-regulation of adhesion molecules ICAM-1, VCAM-1 and E-selectin
• Ladda ner fulltext (pdf) av alpha B-crystallin/HspB5 regulates endothelial-leukocyte interactions by enhancing NF-kappa B-induced up-regulation of adhesion molecules ICAM-1, VCAM-1 and E-selectin

VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation

Hayashi, Makoto; Majumdar, Arindam; Li, Xiujuan; Adler, Jeremy et al.

Ingår i Nature Communications, s. 1672, 2013

• DOI för VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation

GABA-A Channel Subunit Expression in Human Glioma Correlates with Tumor Histology and Clinical Outcome

Smits, Anja; Jin, Zhe; Elsir, Tamador; Pedder, Hugo et al.

Ingår i PLOS ONE, 2012

• DOI för GABA-A Channel Subunit Expression in Human Glioma Correlates with Tumor Histology and Clinical Outcome
• Ladda ner fulltext (pdf) av GABA-A Channel Subunit Expression in Human Glioma Correlates with Tumor Histology and Clinical Outcome

Paladin (X99384) is expressed in the vasculature and shifts from endothelial to vascular smooth muscle cells during mouse development

Wallgard, Elisabet; Nitzsche, Anja; Larsson, Jimmy; Guo, Xiaoyuan et al.

Ingår i Developmental Dynamics, s. 770-786, 2012

• DOI för Paladin (X99384) is expressed in the vasculature and shifts from endothelial to vascular smooth muscle cells during mouse development

Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma

Dimberg, Lina Y.; Dimberg, Anna; Ivarsson, Karolina; Fryknäs, Mårten et al.

Ingår i BMC Cancer, s. 318, 2012

• DOI för Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma
• Ladda ner fulltext (pdf) av Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma

Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFβ2 in vascular abnormalization

Dieterich, Lothar C.; Mellberg, Sofie; Langenkamp, Elise; Zhang, Lei et al.

Ingår i Journal of Pathology, s. 378-390, 2012

• DOI för Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFβ2 in vascular abnormalization

Vascular endothelial growth factor receptor 2 (VEGFR-2) signalling activity in paediatric pilocytic astrocytoma is restricted to tumour endothelial cells

Sikkema, A. H.; de Bont, E. S. J. M.; Molema, G.; Dimberg, Anna et al.

Ingår i Neuropathology and Applied Neurobiology, s. 538-548, 2011

• DOI för Vascular endothelial growth factor receptor 2 (VEGFR-2) signalling activity in paediatric pilocytic astrocytoma is restricted to tumour endothelial cells

Chemokines in Angiogenesis

Dimberg, Anna

Ingår i Current Topics in Microbiology and Immunology, s. 59-80, 2010

• DOI för Chemokines in Angiogenesis

Activated platelets provide a functional microenvironment for the antiangiogenic fragment of histidine-rich glycoprotein

Thulin, Åsa; Ringvall, Maria; Dimberg, Anna; Kårehed, Karin et al.

Ingår i Molecular Cancer Research, s. 1792-1802, 2009

• DOI för Activated platelets provide a functional microenvironment for the antiangiogenic fragment of histidine-rich glycoprotein

Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis

Mellberg, Sofie; Dimberg, Anna; Bahram, Fuad; Hayashi, Makoto et al.

Ingår i The FASEB Journal, s. 1490-1502, 2009

• DOI för Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis

alphaB-crystallin promotes tumor angiogenesis by increasing vascular survival during tube morphogenesis

Dimberg, Anna; Rylova, Svetlana; Dieterich, Lothar C; Olsson, Anna-Karin et al.

Ingår i Blood, s. 2015-2023, 2008

• DOI för alphaB-crystallin promotes tumor angiogenesis by increasing vascular survival during tube morphogenesis

Ninein Is Expressed in the Cytoplasm of Angiogenic Tip-Cells and Regulates Tubular Morphogenesis of Endothelial Cells

Matsumoto, Taro; Schiller, Petter; Dietrich, Lothar C.; Bahram, Fuad et al.

Ingår i Arteriosclerosis, Thrombosis and Vascular Biology, s. 2123-2130, 2008

• DOI för Ninein Is Expressed in the Cytoplasm of Angiogenic Tip-Cells and Regulates Tubular Morphogenesis of Endothelial Cells

Endocan is a VEGF-A and PI3K regulated gene with increased expression in human renal cancer

Rennel, Emma; Mellberg, Sofie; Dimberg, Anna; Petersson, Ludvig et al.

Ingår i Experimental Cell Research, s. 1285-1294, 2007

• DOI för Endocan is a VEGF-A and PI3K regulated gene with increased expression in human renal cancer

FGFR-1 regulates angiogenesis through cytokines interleukin-4 and pleiotrophin

Magnusson, Peetra U; Dimberg, Anna; Mellberg, Sofie; Lukinius, Agneta et al.

Ingår i Blood, s. 4214-4222, 2007

• DOI för FGFR-1 regulates angiogenesis through cytokines interleukin-4 and pleiotrophin

IFN-gamma-induced upregulation of Fc gamma-receptor-I during activation of monocytic cells requires the PKR and NF kappa B pathways

Kårehed, Karin; Dimberg, Anna; Dahl, Staffan; Nilsson, Kenneth et al.

Ingår i Molecular Immunology, s. 615-624, 2007

• DOI för IFN-gamma-induced upregulation of Fc gamma-receptor-I during activation of monocytic cells requires the PKR and NF kappa B pathways

Lentiviral rescue of vascular endothelial growth factor receptor-2 expression in flk1-/- embryonic stem cells shows early priming of endothelial precursors

Li, Xiujuan; Edholm, Dan; Lanner, Fredrik; Breier, Georg et al.

Ingår i Stem Cells, s. 2987-2995, 2007

• DOI för Lentiviral rescue of vascular endothelial growth factor receptor-2 expression in flk1-/- embryonic stem cells shows early priming of endothelial precursors

Inhibition of monocytic differentiation by phosphorylation-deficient Stat1 is associated with impaired expression of Stat2, ICSBP/IRF8 and C/EBP epsilon

Dimberg, Anna; Kårehed, Karin; Nilsson, Kenneth; Öberg, Fredrik

Ingår i Scandinavian Journal of Immunology, s. 271-279, 2006

• DOI för Inhibition of monocytic differentiation by phosphorylation-deficient Stat1 is associated with impaired expression of Stat2, ICSBP/IRF8 and C/EBP epsilon

VEGF receptor signalling: in control of vascular function

Olsson, Anna-Karin; Dimberg, Anna; Kreuger, Johan; Claesson-Welsh, Lena

Ingår i Nature reviews. Molecular cell biology, s. 359-371, 2006

• DOI för VEGF receptor signalling: in control of vascular function

Ectopic and IFN-induced expression of Fas overcomes resistance to Fas-mediated apoptosis in multiple myeloma cells.

Dimberg, Lina; Dimberg, Anna; Ivarsson, Karolina; Strömberg, Thomas et al.

Ingår i Blood, 2005

• DOI för Ectopic and IFN-induced expression of Fas overcomes resistance to Fas-mediated apoptosis in multiple myeloma cells.

Fibroblast growth factor receptor-1 expression is required for hematopoietic but not endothelial cell development

Magnusson, Peetra Ulrica; Ronca, Roberto; Dell'Era, Patrizia; Carlstedt, Pia et al.

Ingår i Arteriosclerosis, Thrombosis and Vascular Biology, s. 944-949, 2005

• DOI för Fibroblast growth factor receptor-1 expression is required for hematopoietic but not endothelial cell development

Proteomic analysis of vascular endothelial growth factor-induced endothelial cell differentiation reveals a role for chloride intracellular channel 4 (CLIC4) in tubular morphogenesis.

Bohman, Svante; Matsumoto, Taro; Suh, Kwang; Dimberg, Anna et al.

Ingår i J Biol Chem, s. 42397-404, 2005

VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis.

Matsumoto, Taro; Bohman, Svante; Dixelius, Johan; Berge, Tone et al.

Ingår i EMBO J, s. 2342-53, 2005

Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone.

Strömberg, Thomas; Dimberg, Anna; Hammarberg, Anna; Carlson, Kristina et al.

Ingår i Blood, s. 3138-47, 2004

Retinoic acid-induced cell cycle arrest of human myeloid cell lines.

Dimberg, A; Oberg, F

Ingår i Leuk Lymphoma, s. 1641, 2003

Ser727/Tyr701-phosphorylated Stat1 is required for the regulation ofc-Myc, cyclins, and p27Kip1 associated with ATRA-induced G0/G1 arrest ofU-937 cells.

Dimberg, A; Karlberg, I; Nilsson, K; Oberg, F

Ingår i Blood, s. 254, 2003

Retinoic acid-induced cell cycle arrest of human myeloid cell lines is associated with sequential down-regulation of c-Myc and cyclin E andposttranscriptional up-regulation of p27(Kip1).

Dimberg, A; Bahram, F; Karlberg, I; Larsson, LG et al.

Ingår i Blood, s. 2199, 2002

Phosphorylation-deficient Stat1 inhibits retinoic acid-induceddifferentiation and cell cycle arrest in U-937 monoblasts.

Dimberg, A; Nilsson, K; Oberg, F

Ingår i Blood, s. 2870, 2000