Taija Mäkinen – Reglering av lymfkärlssystemet

Intravital Imaging of Disease Mechanisms in a Mouse Model of CCM Skin Lesions-Brief Report

Orlich, Michael M.; Norrén, Amanda; Desai, Malavika; Holm, Annegret et al.

Ingår i Arteriosclerosis, Thrombosis and Vascular Biology, s. 113-118, 2025

• DOI för Intravital Imaging of Disease Mechanisms in a Mouse Model of CCM Skin Lesions-Brief Report
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iSuRe-HadCre is an essential tool for effective conditional genetics

Garcia-Gonzalez, Irene; Rocha, Susana F.; Hamidi, Anahita; Garcia-Ortega, Lourdes et al.

Ingår i Nucleic Acids Research, 2024

• DOI för iSuRe-HadCre is an essential tool for effective conditional genetics
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Lymphatic malformations: mechanistic insights and evolving therapeutic frontiers

Petkova, Milena; Ferby, Ingvar; Mäkinen, Taija

Ingår i Journal of Clinical Investigation, 2024

• DOI för Lymphatic malformations: mechanistic insights and evolving therapeutic frontiers
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Penile cavernous sinusoids are Prox1-positive hybrid vessels

Schnabellehner, Sarah; Kraft, Marle; Schoofs, Hans; Ortsäter, Henrik et al.

Ingår i Vascular Biology, 2024

• DOI för Penile cavernous sinusoids are Prox1-positive hybrid vessels
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Specialized post-arterial capillaries facilitate adult bone remodelling

Mohanakrishnan, Vishal; Sivaraj, Kishor K.; Jeong, Hyun-Woo; Bovay, Esther et al.

Ingår i Nature Cell Biology, 2024

• DOI för Specialized post-arterial capillaries facilitate adult bone remodelling
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APOLD1 loss causes endothelial dysfunction involving cell junctions, cytoskeletal architecture, and Weibel-Palade bodies, while disrupting hemostasis

Stritt, Simon; Nurden, Paquita; Nurden, Alan T.; Schved, Jean-François et al.

Ingår i Haematologica, s. 772-784, 2023

• DOI för APOLD1 loss causes endothelial dysfunction involving cell junctions, cytoskeletal architecture, and Weibel-Palade bodies, while disrupting hemostasis
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Hemogenic activity of lymphatic endothelium unleashed

Mäkinen, Taija

Ingår i Nature Cardiovascular Research, s. 230-231, 2023

• DOI för Hemogenic activity of lymphatic endothelium unleashed

Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation

Petkova, Milena; Kraft, Marle; Stritt, Simon; Martinez-Corral, Ines et al.

Ingår i Journal of Experimental Medicine, 2023

• DOI för Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation
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Mapping the lymphatic system across body scales and expertise domains: A report from the 2021 National Heart, Lung, and Blood Institute workshop at the Boston Lymphatic Symposium

Singhal, Dhruv; Börner, Katy; Chaikof, Elliot L.; Detmar, Michael et al.

Ingår i Frontiers in Physiology, 2023

• DOI för Mapping the lymphatic system across body scales and expertise domains: A report from the 2021 National Heart, Lung, and Blood Institute workshop at the Boston Lymphatic Symposium
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Molecular anatomy of adult mouse leptomeninges

Pietilä, Riikka; Del Gaudio, Francesca; He, Liqun; Vázquez-Liébanas, Elisa et al.

Ingår i Neuron, 2023

• DOI för Molecular anatomy of adult mouse leptomeninges
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Angiogenesis depends upon EPHB4-mediated export of collagen IV from vascular endothelial cells

Chen, Di; Hughes, Elizabeth D.; Saunders, Thomas L.; Wu, Jiangping et al.

Ingår i JCI Insight, 2022

• DOI för Angiogenesis depends upon EPHB4-mediated export of collagen IV from vascular endothelial cells
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Cdh5-lineage–independent origin of dermal lymphatics shown by temporally restricted lineage tracing

Zhang, Yan; Ortsäter, Henrik; Martinez-Corral, Ines; Mäkinen, Taija

Ingår i Life Science Alliance, 2022

• DOI för Cdh5-lineage–independent origin of dermal lymphatics shown by temporally restricted lineage tracing
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Cellular Origin of Sporadic CCMs

Betsholtz, Christer; Gängel, Konstantin; Mäkinen, Taija

Ingår i New England Journal of Medicine, s. 1291-1291, 2022

• DOI för Cellular Origin of Sporadic CCMs

Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression

Korhonen, Emilia A.; Murtomäki, Aino; Jha, Sawan Kumar; Anisimov, Andrey et al.

Ingår i Journal of Clinical Investigation, 2022

• DOI för Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression
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The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular research

Muhl, Lars; He, Liqun; Sun, Ying; Andaloussi Mäe, Maarja et al.

Ingår i Stem Cell Reports, s. 1089-1104, 2022

• DOI för The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular research

An inducible Cldn11-CreER^T2 mouse line for selective targeting of lymphatic valves

Ortsäter, Henrik; Hernández-Vásquez, Magda N.; Ulvmar, Maria H.; Gow, Alexander et al.

Ingår i Genesis, 2021

• DOI för An inducible Cldn11-CreER^T2 mouse line for selective targeting of lymphatic valves
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Homeostatic maintenance of the lymphatic vasculature

Stritt, Simon; Koltowska, Katarzyna; Mäkinen, Taija

Ingår i Trends in Molecular Medicine, s. 955-970, 2021

• DOI för Homeostatic maintenance of the lymphatic vasculature
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Lymphatic Malformations: Genetics, Mechanisms and Therapeutic Strategies

Mäkinen, Taija; Boon, Laurence M.; Vikkula, Miikka; Alitalo, Kari

Ingår i Circulation Research, s. 136-154, 2021

• DOI för Lymphatic Malformations: Genetics, Mechanisms and Therapeutic Strategies

Mutations in EPHB4 cause human venous valve aplasia

Lyons, Oliver; Walker, James; Seet, Christopher; Ikram, Mohammed et al.

Ingår i JCI Insight, 2021

• DOI för Mutations in EPHB4 cause human venous valve aplasia
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Transcription factor FOXP2 is a flow-induced regulator of collecting lymphatic vessels

Hernández Vásquez, Magda; Ulvmar, Maria H.; González-Loyola, Alejandra; Kritikos, Ioannis et al.

Ingår i EMBO Journal, 2021

• DOI för Transcription factor FOXP2 is a flow-induced regulator of collecting lymphatic vessels
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Upregulation of VCAM-1 in lymphatic collectors supports dendritic cell entry and rapid migration to lymph nodes in inflammation

Arasa, Jorge; Collado-Diaz, Victor; Kritikos, Ioannis; Medina-Sanchez, Jessica Danielly et al.

Ingår i Journal of Experimental Medicine, 2021

• DOI för Upregulation of VCAM-1 in lymphatic collectors supports dendritic cell entry and rapid migration to lymph nodes in inflammation

Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation

Martinez-Corral, Ines; Zhang, Yan; Petkova, Milena; Ortsäter, Henrik et al.

Ingår i Nature Communications, 2020

• DOI för Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation
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EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity

Frye, Maike; Stritt, Simon; Ortsäter, Henrik; Hernandez Vasquez, Magda et al.

Ingår i eLIFE, 2020

• DOI för EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity
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Tamoxifen-independent recombination of reporter genes limits lineage tracing and mosaic analysis using CreER(T2) lines

Alvarez, Alberto; Martinez-Corral, Ines; Daubel, Nina; Betsholtz, Christer et al.

Ingår i Transgenic research, s. 53-68, 2020

• DOI för Tamoxifen-independent recombination of reporter genes limits lineage tracing and mosaic analysis using CreER(T2) lines
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Gut microbiota regulates lacteal integrity by inducing VEGF-C in intestinal villus macrophages

Suh, Sang Heon; Choe, Kibaek; Hong, Seon Pyo; Jeong, Seung-hwan et al.

Ingår i EMBO Reports, 2019

• DOI för Gut microbiota regulates lacteal integrity by inducing VEGF-C in intestinal villus macrophages

Identification of ILK as a critical regulator of VEGFR3 signalling and lymphatic vascular growth

Urner, Sofia; Planas-Paz, Lara; Hilger, Laura Sophie; Henning, Carina et al.

Ingår i EMBO Journal, 2019

• DOI för Identification of ILK as a critical regulator of VEGFR3 signalling and lymphatic vascular growth

Neurobiology: A Drain At The Base Of The Brain

Mäkinen, Taija

Ingår i Nature, s. 34-35, 2019

• DOI för Neurobiology: A Drain At The Base Of The Brain

YAP and TAZ Negatively Regulate Prox1 During Developmental and Pathologic Lymphangiogenesis

Cho, Hyunsoo; Kim, Jaeryung; Ahn, Ji Hoon; Hong, Young-Kwon et al.

Ingår i Circulation Research, s. 225-242, 2019

• DOI för YAP and TAZ Negatively Regulate Prox1 During Developmental and Pathologic Lymphangiogenesis

Distinct roles of VE-cadherin for development and maintenance of specific lymph vessel beds

Haegerling, Rene; Hoppe, Esther; Dierkes, Cathrin; Stehling, Martin et al.

Ingår i EMBO Journal, 2018

• DOI för Distinct roles of VE-cadherin for development and maintenance of specific lymph vessel beds

Genetic Lineage Tracing of Lymphatic Endothelial Cells in Mice.

Martinez-Corral, Ines; Mäkinen, Taija

Ingår i Methods in Molecular Biology, s. 37-53, 2018

• DOI för Genetic Lineage Tracing of Lymphatic Endothelial Cells in Mice.

Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms

Zhang, Yan; Ulvmar, Maria H.; Stanczuk, Lukas; Martinez-Corral, Ines et al.

Ingår i Nature Communications, 2018

• DOI för Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms
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Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program

Frye, Maike; Taddei, Andrea; Dierkes, Cathrin; Martinez-Corral, Ines et al.

Ingår i Nature Communications, 2018

• DOI för Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program
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PROX1 is a transcriptional regulator of MMP14

Gramolelli, Silvia; Cheng, Jianpin; Martinez-Corral, Ines; Vaha-Koskela, Markus et al.

Ingår i Scientific Reports, 2018

• DOI för PROX1 is a transcriptional regulator of MMP14
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Transient loss of venous integrity during developmental vascular remodeling leads to red blood cell extravasation and clearance by lymphatic vessels

Zhang, Yang; Daubel, Nina; Stritt, Simon; Mäkinen, Taija

Ingår i Development, 2018

• DOI för Transient loss of venous integrity during developmental vascular remodeling leads to red blood cell extravasation and clearance by lymphatic vessels

Dachsousl-Fat4 Signaling Controls Endothelial Cell Polarization During Lymphatic Valve Morphogenesis-Brief Report

Pujol, Francoise; Hodgson, Tina; Martinez-Corral, Ines; Prats, Anne-Catherine et al.

Ingår i Arteriosclerosis, Thrombosis and Vascular Biology, s. 1732-1735, 2017

• DOI för Dachsousl-Fat4 Signaling Controls Endothelial Cell Polarization During Lymphatic Valve Morphogenesis-Brief Report

Human venous valve disease caused by mutations in FOXC2 and GJC2

Lyons, Oliver; Saha, Prakash; Seet, Christopher; Kuchta, Adam et al.

Ingår i Journal of Experimental Medicine, s. 2437-2452, 2017

• DOI för Human venous valve disease caused by mutations in FOXC2 and GJC2
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Human Venous Valve Disease Caused by Mutations in FOXC2 and GJC2

Lyons, Oliver; Saha, Prakash; Seet, Christopher; Kuchta, Adam et al.

Ingår i Journal of Vascular Research, s. 62-62, 2017

Lymphangiogenesis guidance by paracrine and pericellular factors

Vaahtomeri, Kari; Karaman, Sinem; Mäkinen, Taija; Alitalo, Kari

Ingår i Genes & Development, s. 1615-1634, 2017

• DOI för Lymphangiogenesis guidance by paracrine and pericellular factors
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Mechanisms underlying human venous valve disease caused by mutations in Foxc2 and connexin47

Lyons, O. T. A.; Saha, P.; Seet, C.; Kuchta, A. et al.

Ingår i British Journal of Surgery, s. 8-8, 2017

• DOI för Mechanisms underlying human venous valve disease caused by mutations in Foxc2 and connexin47

Smooth muscle cell recruitment to lymphatic vessels requires PDGFB and impacts vessel size but not identity

Wang, Yixin; Jin, Yi; Mäe, Maarja Andaloussi; Zhang, Yang et al.

Ingår i Development, s. 3590-3601, 2017

• DOI för Smooth muscle cell recruitment to lymphatic vessels requires PDGFB and impacts vessel size but not identity

Vascular heterogeneity and specialization in development and disease

Potente, Michael; Mäkinen, Taija

Ingår i Nature reviews. Molecular cell biology, s. 477-494, 2017

• DOI för Vascular heterogeneity and specialization in development and disease
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EPHB4 kinase-inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis

Martin-Almedina, Silvia; Martinez-Corral, Ines; Holdhus, Rita; Vicente, Andres et al.

Ingår i Journal of Clinical Investigation, s. 3080-3088, 2016

• DOI för EPHB4 kinase-inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis
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Heterogeneity in the lymphatic vascular system and its origin

Ulvmar, Maria H.; Mäkinen, Taija

Ingår i Cardiovascular Research, s. 310-321, 2016

• DOI för Heterogeneity in the lymphatic vascular system and its origin
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Lymphatic System in Cardiovascular Medicine

Aspelund, Aleksanteri; Robciuc, Marius R.; Karaman, Sinem; Mäkinen, Taija et al.

Ingår i Circulation Research, s. 515-530, 2016

• DOI för Lymphatic System in Cardiovascular Medicine

Pdgfrb-Cre targets lymphatic endothelial cells of both venous and non-venous origins

Ulvmar, Maria H; Martinez-Corral, Ines; Stanczuk, Lukas; Mäkinen, Taija

Ingår i Genesis, s. 350-358, 2016

• DOI för Pdgfrb-Cre targets lymphatic endothelial cells of both venous and non-venous origins

Vegfr3-CreER (T2) mouse, a new genetic tool for targeting the lymphatic system

Martinez-Corral, Ines; Stanczuk, Lukas; Frye, Maike; Ulvmar, Maria Helena et al.

Ingår i Angiogenesis, s. 433-445, 2016

• DOI för Vegfr3-CreER (T2) mouse, a new genetic tool for targeting the lymphatic system
• Ladda ner fulltext (pdf) av Vegfr3-CreER (T2) mouse, a new genetic tool for targeting the lymphatic system

A Transgenic Prox1-Cre-tdTomato Reporter Mouse for Lymphatic Vessel Research

Bianchi, Roberta; Teijeira, Alvaro; Proulx, Steven T.; Christiansen, Ailsa J. et al.

Ingår i PLOS ONE, 2015

• DOI för A Transgenic Prox1-Cre-tdTomato Reporter Mouse for Lymphatic Vessel Research
• Ladda ner fulltext (pdf) av A Transgenic Prox1-Cre-tdTomato Reporter Mouse for Lymphatic Vessel Research

cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels

Stanczuk, Lukas; Martinez-Corral, Ines; Ulvmar, Maria H.; Zhang, Yang et al.

Ingår i Cell Reports, s. 1708-1721, 2015

• DOI för cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels
• Ladda ner fulltext (pdf) av cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels

FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature

Sabine, Amelie; Bovay, Esther; Demir, Cansaran Saygili; Kimura, Wataru et al.

Ingår i Journal of Clinical Investigation, s. 3861-3877, 2015

• DOI för FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature

Nonvenous Origin of Dermal Lymphatic Vasculature

Martinez-Corral, Ines; Ulvmar, Maria H.; Stanczuk, Lukas; Tatin, Florence et al.

Ingår i Circulation Research, s. 1649-1654, 2015

• DOI för Nonvenous Origin of Dermal Lymphatic Vasculature

Organ-Specific Origins of Lymphatic Vasculature

Mäkinen, Taija

Ingår i Journal of Vascular Research, s. 18-19, 2015

Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction

Rouhani, Sherin J.; Eccles, Jacob D.; Riccardi, Priscila; Peske, J. David et al.

Ingår i Nature Communications, 2015

• DOI för Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction

Therapeutic Insights to Lymphangiogenic Growth Factors

Aspelund, Aleksanteri; Tammela, Tuomas; Antila, Salli; Nurmi, Harri et al.

Ingår i Journal of Vascular Research, s. 19-19, 2015

VEGFR3 does not sustain retinal angiogenesis without VEGFR2

Zarkada, Georgia; Heinolainen, Krista; Mäkinen, Taija; Kubota, Yoshiaki et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 761-766, 2015

• DOI för VEGFR3 does not sustain retinal angiogenesis without VEGFR2

Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity

Park, Dae-Young; Lee, Junyeop; Park, Intae; Choi, Dongwon et al.

Ingår i Journal of Clinical Investigation, s. 3960-3974, 2014

• DOI för Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity

Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life.

Hess, Paul R; Rawnsley, David R; Jakus, Zoltán; Yang, Yiqing et al.

Ingår i Journal of Clinical Investigation, 2014

• DOI för Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life.

The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel

Aspelund, Aleksanteri; Tammela, Tuomas; Antila, Salli; Nurmi, Harri et al.

Ingår i Journal of Clinical Investigation, s. 3975-3986, 2014

• DOI för The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel

Adrenomedullin haploinsufficiency predisposes to secondary lymphedema.

Nikitenko, Leonid L; Shimosawa, Tatsuo; Henderson, Stephen; Mäkinen, Taija et al.

Ingår i Journal of Investigative Dermatology, 2013

• DOI för Adrenomedullin haploinsufficiency predisposes to secondary lymphedema.

Flow control in our vessels: vascular valves make sure there is no way back.

Bazigou, Eleni; Mäkinen, Taija

Ingår i Cellular and Molecular Life Sciences (CMLS), 2013

• DOI för Flow control in our vessels: vascular valves make sure there is no way back.

Planar cell polarity protein Celsr1 regulates endothelial adherens junctions and directed cell rearrangements during valve morphogenesis.

Tatin, Florence; Taddei, Andrea; Weston, Anne; Fuchs, Elaine et al.

Ingår i Developmental Cell, 2013

• DOI för Planar cell polarity protein Celsr1 regulates endothelial adherens junctions and directed cell rearrangements during valve morphogenesis.

Regulation of lymphatic vascular morphogenesis: Implications for pathological (tumor) lymphangiogenesis

Martinez-Corral, Ines; Mäkinen, Taija

Ingår i Experimental Cell Research, s. 1618-1625, 2013

• DOI för Regulation of lymphatic vascular morphogenesis: Implications for pathological (tumor) lymphangiogenesis

Blood flow reprograms lymphatic vessels to blood vessels.

Chen, Chiu-Yu; Bertozzi, Cara; Zou, Zhiying; Yuan, Lijun et al.

Ingår i Journal of Clinical Investigation, 2012

• DOI för Blood flow reprograms lymphatic vessels to blood vessels.

Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation.

Sabine, Amélie; Agalarov, Yan; Maby-El Hajjami, Hélène; Jaquet, Muriel et al.

Ingår i Developmental Cell, 2012

• DOI för Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation.

Mutations in KIF11 cause autosomal-dominant microcephaly variably associated with congenital lymphedema and chorioretinopathy.

Ostergaard, Pia; Simpson, Michael A; Mendola, Antonella; Vasudevan, Pradeep et al.

Ingår i American Journal of Human Genetics, 2012

• DOI för Mutations in KIF11 cause autosomal-dominant microcephaly variably associated with congenital lymphedema and chorioretinopathy.

Paladin (X99384) is expressed in the vasculature and shifts from endothelial to vascular smooth muscle cells during mouse development

Wallgard, Elisabet; Nitzsche, Anja; Larsson, Jimmy; Guo, Xiaoyuan et al.

Ingår i Developmental Dynamics, s. 770-786, 2012

• DOI för Paladin (X99384) is expressed in the vasculature and shifts from endothelial to vascular smooth muscle cells during mouse development

Smooth muscle-endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation.

Lutter, Sophie; Xie, Sherry; Tatin, Florence; Mäkinen, Taija

Ingår i Journal of Cell Biology, 2012

• DOI för Smooth muscle-endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation.

Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice.

Bazigou, Eleni; Lyons, Oliver T A; Smith, Alberto; Venn, Graham E et al.

Ingår i Journal of Clinical Investigation, 2011

• DOI för Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice.

Mutations in FOXC2 in humans (lymphoedema distichiasis syndrome) cause lymphatic dysfunction on dependency.

Mellor, Russell H; Tate, Naomi; Stanton, Anthony W B; Hubert, Charlotte et al.

Ingår i Journal of Vascular Research, 2011

• DOI för Mutations in FOXC2 in humans (lymphoedema distichiasis syndrome) cause lymphatic dysfunction on dependency.

Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome).

Ostergaard, Pia; Simpson, Michael A; Connell, Fiona C; Steward, Colin G et al.

Ingår i Nature Genetics, 2011

• DOI för Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome).

Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesis.

Calvo, Charles-Félix; Fontaine, Romain H; Soueid, Jihane; Tammela, Tuomas et al.

Ingår i Genes & Development, 2011

• DOI för Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesis.

VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling.

Tammela, Tuomas; Zarkada, Georgia; Nurmi, Harri; Jakobsson, Lars et al.

Ingår i Nature Cell Biology, 2011

• DOI för VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling.

EphB-ephrin-B2 interactions are required for thymus migration during organogenesis.

Foster, Katie E; Gordon, Julie; Cardenas, Kim; Veiga-Fernandes, Henrique et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2010

• DOI för EphB-ephrin-B2 interactions are required for thymus migration during organogenesis.

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis.

Wang, Yingdi; Nakayama, Masanori; Pitulescu, Mara E; Schmidt, Tim S et al.

Ingår i Nature, 2010

• DOI för Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis.

Lymphatic dysfunction, not aplasia, underlies Milroy disease.

Mellor, Russell H; Hubert, Charlotte E; Stanton, Anthony W B; Tate, Naomi et al.

Ingår i Microcirculation, 2010

• DOI för Lymphatic dysfunction, not aplasia, underlies Milroy disease.

Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis.

Bazigou, Eleni; Xie, Sherry; Chen, Chun; Weston, Anne et al.

Ingår i Developmental Cell, 2009

• DOI för Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis.

Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos.

Haiko, Paula; Mäkinen, Taija; Keskitalo, Salla; Taipale, Jussi et al.

Ingår i Molecular and Cellular Biology, 2008

• DOI för Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos.

Lymphangiogenesis in development and disease.

Mäkinen, Taija; Alitalo, Kari

Ingår i Novartis Foundation symposium, 2007

Lymphatic vasculature: a molecular perspective.

Hosking, Brett; Mäkinen, Taija

Ingår i Bioessays, 2007

• DOI för Lymphatic vasculature: a molecular perspective.

Molecular mechanisms of lymphatic vascular development.

Mäkinen, Taija; Norrmén, C; Petrova, T V

Ingår i Cellular and Molecular Life Sciences (CMLS), 2007

• DOI för Molecular mechanisms of lymphatic vascular development.

EphB receptors and ephrin-B3 regulate axon guidance at the ventral midline of the embryonic mouse spinal cord.

Kadison, Stephanie R; Mäkinen, Taija; Klein, Rüdiger; Henkemeyer, Mark et al.

Ingår i Journal of Neuroscience, 2006

• DOI för EphB receptors and ephrin-B3 regulate axon guidance at the ventral midline of the embryonic mouse spinal cord.

Lymphangiogenic growth factor responsiveness is modulated by postnatal lymphatic vessel maturation.

Karpanen, Terhi; Wirzenius, Maria; Mäkinen, Taija; Veikkola, Tanja et al.

Ingår i American Journal of Pathology, 2006

• DOI för Lymphangiogenic growth factor responsiveness is modulated by postnatal lymphatic vessel maturation.

Regulation of lymphangiogenesis--from cell fate determination to vessel remodeling.

Karpanen, Terhi; Mäkinen, Taija

Ingår i Experimental Cell Research, 2006

• DOI för Regulation of lymphangiogenesis--from cell fate determination to vessel remodeling.

Neural guidance molecules regulate vascular remodeling and vessel navigation.

Eichmann, Anne; Mäkinen, Taija; Alitalo, Kari

Ingår i Genes & Development, 2005

• DOI för Neural guidance molecules regulate vascular remodeling and vessel navigation.

PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature.

Mäkinen, Taija; Adams, Ralf H; Bailey, John; Lu, Qiang et al.

Ingår i Genes & Development, 2005

• DOI för PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature.

Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma.

Wang, Hsei-Wei; Trotter, Matthew W B; Lagos, Dimitrios; Bourboulia, Dimitra et al.

Ingår i Nature Genetics, 2004

• DOI för Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma.

Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis.

He, Yulong; Rajantie, Iiro; Ilmonen, Maritta; Mäkinen, Taija et al.

Ingår i Cancer Research, 2004

• DOI för Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis.

Vegfc is required for vascular development and endoderm morphogenesis in zebrafish.

Ober, Elke A; Olofsson, Birgitta; Mäkinen, Taija; Jin, Suk-Won et al.

Ingår i EMBO Reports, 2004

• DOI för Vegfc is required for vascular development and endoderm morphogenesis in zebrafish.

Intrinsic versus microenvironmental regulation of lymphatic endothelial cell phenotype and function.

Veikkola, Tanja; Lohela, Marja; Ikenberg, Kristian; Mäkinen, Taija et al.

Ingår i The FASEB Journal, 2003

• DOI för Intrinsic versus microenvironmental regulation of lymphatic endothelial cell phenotype and function.

Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites

Dixelius, Johan; Mäkinen, Taija; Wirzenius, Maria; Karkkainen, Marika J. et al.

Ingår i Journal of Biological Chemistry, s. 40973-40979, 2003

• DOI för Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites

Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites

Dixelius, Johan; Mäkinen, Taija; Wirzenius, Maria; Karkkainen, Marika J. et al.

Ingår i J Biol Chem, s. 40973, 2003

Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea.

Kubo, Hajime; Cao, Renhai; Brakenhielm, Ebba; Mäkinen, Taija et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2002

• DOI för Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea.

Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor.

Petrova, Tatiana V; Mäkinen, Taija; Mäkelä, Tomi P; Saarela, Janna et al.

Ingår i EMBO Journal, 2002

Lymphatic endothelium: a new frontier of metastasis research.

Karkkainen, Marika J; Mäkinen, Taija; Alitalo, Kari

Ingår i Nature Cell Biology, 2002

• DOI för Lymphatic endothelium: a new frontier of metastasis research.

[Lymphatic growth factors play a part in metastasis formation].

Mäkinen, Taija

Ingår i Duodecim, 2002

Molecular mechanisms of lymphangiogenesis.

Mäkinen, Taija; Alitalo, K

Ingår i Cold Spring Harbor Symposia on Quantitative Biology, 2002

Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3.

Mäkinen, Taija; Jussila, L; Veikkola, T; Karpanen, T et al.

Ingår i Nature Medicine, 2001

• DOI för Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3.

Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3.

Mäkinen, Taija; Veikkola, T; Mustjoki, S; Karpanen, T et al.

Ingår i EMBO Journal, 2001

• DOI för Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3.

Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice.

Veikkola, T; Jussila, L; Mäkinen, Taija; Karpanen, T et al.

Ingår i EMBO Journal, 2001

• DOI för Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice.

Monoclonal antibodies to vascular endothelial growth factor-D block its interactions with both VEGF receptor-2 and VEGF receptor-3.

Achen, M G; Roufail, S; Domagala, T; Catimel, B et al.

Ingår i European Journal of Biochemistry, 2000

Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1.

Mäkinen, Taija; Olofsson, B; Karpanen, T; Hellman, U et al.

Ingår i Journal of Biological Chemistry, 1999