Irina Velikyan
Associate professor at Department of Surgical Sciences; Molecular imaging and medical physics
- E-mail:
- irina.velikyan@akademiska.se
- Visiting address:
- Akademiska sjukhuset, ingång 70, 1tr
- Postal address:
- Akademiska sjukhuset, ingång 70, 1tr
751 85 UPPSALA
Visiting researcher at Department of Medicinal Chemistry; Translational PET Imaging
- E-mail:
- irina.velikyan@ilk.uu.se
- Visiting address:
- Dag Hammarskjöldsv 14C, 3tr
- Postal address:
- Dag Hammarskjöldsv 14C, 3tr
751 83 Uppsala
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Publications
Selection of publications
- Organ biodistribution of Germanium-68 in rat in the presence and absence of [68Ga]Ga-DOTA-TOC for the extrapolation to the human organ and whole-body radiation dosimetry (2013)
- Organ biodistribution of Germanium-68 in rat in the presence and absence of [Ga-68]Ga-DOTA-TOC for the extrapolation to the human organ and whole-body radiation dosimetry (2013)
- Synthesis and preclinical evaluation of Ga-68-labelled collagelin analogues for imaging and quantification of fibrosis (2013)
- Comparison of radiation dosimetry of [Ga-68]Ga-DOTA-TOC and [Ga-68]Ga-DOTA-TATE in patients affected by neuroendocrine tumours (2013)
- Ga-68-labelling of Exendin-4, preclinical evaluation of the resultant tracer for the imaging and quantification of insulinomas, and case patient examination (2013)
- Ga-68-Labeling of RGD peptides and biodistribution (2012)
- 68Ga-Labeling of RGD peptides and biodistribution (2012)
- In vitro autoradiography of carcinoembryonic antigen in tissue from patients with colorectal cancer using multifunctional antibody TF2 and 67/68Ga-labeled haptens by pretargeting (2012)
- Pancreatic uptake of [68Ga]DO3A-Exendin4 is mediated by the GLP-1 receptor (2012)
- Synthesis and characterization of a high affinity NOTA-conjugated bombesin antagonist for GRPR-targeted tumor imaging (2012)
- Molecular Imaging and Radiotherapy (2012)
- One pot preparation of Ga-68-labelled macroaggregated albumin for PET-imaging of acute pulmonary embolism and myocardial perfusion quantification (2012)
- Robust labeling and comparative preclinical characterization of DOTA-TOC and DOTA-TATE (2012)
- Positron Emitting [Ga-68]Ga-Based Imaging Agents (2011)
Recent publications
- Introduction of a fatty acid chain modification to prolong circulatory half-life of a radioligand towards glucose-dependent insulinotropic polypeptide receptor (2024)
- Regional distribution of mechanical strain and macrophage-associated lung inflammation after ventilator-induced lung injury (2024)
- Human Epidermal Growth Factor Receptor 2-Targeting [68Ga]Ga-ABY-025 PET/CT Predicts Early Metabolic Response in Metastatic Breast Cancer. (2023)
- Radiotracers for Imaging of Fibrosis (2023)
- Monitoring beta-Cell Survival After Intrahepatic Islet Transplantation Using Dynamic Exendin PET Imaging (2023)
All publications
Articles
- Introduction of a fatty acid chain modification to prolong circulatory half-life of a radioligand towards glucose-dependent insulinotropic polypeptide receptor (2024)
- Regional distribution of mechanical strain and macrophage-associated lung inflammation after ventilator-induced lung injury (2024)
- Human Epidermal Growth Factor Receptor 2-Targeting [68Ga]Ga-ABY-025 PET/CT Predicts Early Metabolic Response in Metastatic Breast Cancer. (2023)
- Radiotracers for Imaging of Fibrosis (2023)
- Monitoring beta-Cell Survival After Intrahepatic Islet Transplantation Using Dynamic Exendin PET Imaging (2023)
- Imaging of the Glucose-Dependent Insulinotropic Polypeptide Receptor Using a Novel Radiolabeled Peptide Rationally Designed Based on Endogenous GIP and Synthetic Exendin-4 Sequences (2023)
- Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist (2022)
- Glucagonlike Peptide-1 Receptor Imaging in Individuals with Type 2 Diabetes (2022)
- PET-CT imaging of pulmonary inflammation using [Ga-68]Ga-DOTA-TATE (2022)
- Comparison of Ga-68-PSMA PET/CT with fluoride PET/CT for detection of bone metastatic disease in prostate cancer (2022)
- Drug Occupancy Assessment at the Glucose-Dependent Insulinotropic Polypeptide Receptor by Positron Emission Tomography (2021)
- Imaging of the Glucagon Receptor in Subjects with Type 2 Diabetes (2021)
- Receptor depletion and recovery in small-intestinal neuroendocrine tumors and normal tissues after administration of a single intravenous dose of octreotide measured by Ga-68-DOTATOC PET/CT (2021)
- Ga-68-DOTATOC-PET/MRI and C-11-5-HTP-PET/MRI are superior to Ga-68-DOTATOC-PET/CT for neuroendocrine tumour imaging (2021)
- Theranostic Approach in Breast Cancer A Treasured Tailor for Future Oncology (2021)
- Exploring the GLP-1-GLP-1R axis in porcine pancreas and gastrointestinal tract in vivo by ex vivo autoradiography (2021)
- Discovery, optimization and biodistribution of an Affibody molecule for imaging of CD69 (2021)
- Radiolabelling and positron emission tomography imaging of a high-affinity peptide binder to collagen type 1 (2021)
- Prospective data-driven respiratory gating of [Ga-68]Ga-DOTATOC PET/CT (2021)
- Improved Radiolytic Stability of a 68Ga-labelled Collagelin Analogue for the Imaging of Fibrosis (2021)
- Kinetic analysis of HER2-binding ABY-025 Affibody molecule using dynamic PET in patients with metastatic breast cancer (2020)
- Receptor occupancy of dual glucagon-like peptide 1/glucagon receptor agonist SAR425899 in individuals with type 2 diabetes (2020)
- Tumor-to-blood ratio for assessment of somatostatin receptor density in neuroendocrine tumors using 68Ga-DOTATOC and 68Ga-DOTATATE. (2020)
- In vivo instability of 177Lu-DOTATATE during peptide receptor radionuclide therapy (2020)
- Carbon Flux as a Measure of Prostate Cancer Aggressiveness (2020)
- Comparison of 68Ga-PSMA-11 PET/CT with 11C-acetate PET/CT in re-staging of prostate cancer relapse (2020)
- (Radio)Theranostic Patient Management in Oncology Exemplified by Neuroendocrine Neoplasms, Prostate Cancer, and Breast Cancer (2020)
- GMP production of [Ga-68]Ga-BOT5035 for imaging of liver fibrosis in microdosing phase 0 study (2020)
- Advances in GLP-1 receptor targeting radiolabeled agent development and prospective of theranostics (2020)
- Automated GMP-Compliant Production of [Ga-68]Ga-DO3A-Tuna-2 for PET Microdosing Studies of the Glucagon Receptor in Humans (2020)
- Assessment of glucagon receptor occupancy by Positron Emission Tomography in non-human primates (2019)
- Regularized reconstruction of digital time-of-flight Ga-68-PSMA-11 PET/CT for the detection of recurrent disease in prostate cancer patients (2019)
- Localizing biochemical recurrence of prostate cancer using [68Ga]-PSMA-11 PET/CT and [11C]-acetate PET/CT (2019)
- First-in-class positron emission tomography tracer for the glucagon receptor (2019)
- Diagnostic HER2-binding radiopharmaceutical, [Ga-68]Ga-ABY-025, for routine clinical use in breast cancer patients (2019)
- Kinetic Analysis of the HER2-binding ABY-025 Affibody Using Dynamic PET in Patients with Metastatic Breast Cancer (2018)
- Comparison of Ga-68-DOTATATE and Lu-177-DOTATATE kinetics in neuroendocrine tumors (2018)
- 177Lu-DOTATATE Peptide Receptor Radionuclide Therapy; Gender Differences in Small Intestinal and Pancreatic Neuroendocrine Tumors (2018)
- Increased Expression of GLP-1R in Proliferating Islets of Men1 Mice is Detectable by [Ga-68]Ga-DO3A-VS-Cys(40)- Exendin-4/PET (2018)
- Prospective of Ga-68 Radionuclide Contribution to the Development of Imaging Agents for Infection and Inflammation (2018)
- Preparation and evaluation of a Ga-68-labeled RGD-containing octapeptide for noninvasive imaging of angiogenesis (2018)
- In-vivo stability of 177Lu-DOTATATE during peptide receptor radionuclide therapy (2018)
- Species differences in pancreatic binding of DO3A-VS-Cys40-Exendin4 (2017)
- First-in-class PET tracer for the glucagon receptor (2017)
- Current Status of Radiopharmaceuticals for the Theranostics of Neuroendocrine Neoplasms (2017)
- Generation and evaluation of antibody agents for molecular imaging of CD44v6-expressing cancers (2017)
- Parametric Net Influx Rate Images of 68Ga-DOTATOC and 68Ga-DOTATATE (2017)
- Low tracer availability of Ga-68-DOTATOC and Ga-68-DOTATATE in blood for patients with high SSTR density leads to non-linear correlation between SUV and K-i (2017)
- Intra-image referencing for simplified assessment of HER2-expression in breast cancer metastases using the Affibody molecule ABY-025 with PET and SPECT. (2017)
- Radiochemistry and Preclinical Evaluation of Two Novel Peptide Analogues Targeting Glucagon Receptor for AntiDiabetic Drug Development (2017)
- Fully automated GMP production of [Ga-68]Ga-DO3A-VS-Cys(40)-Exendin-4 for clinical use (2017)
- Quantification of Beta-Cell Mass in Intramuscular Islet Grafts using Radiolabeled Exendin-4 (2016)
- Comparison of PET/CT and PET/MR-based Ga-68-DOTATOC standardized uptake values (2016)
- Feasibility of 68Ga-labeled Siglec-9 peptide for the imaging of acute lung inflammation (2016)
- Biodistribution and Radiation Dosimetry of the Anti-HER2 Affibody Molecule Ga-68-ABY-025 in Breast Cancer Patients (2016)
- Measuring HER2-Receptor Expression In Metastatic Breast Cancer Using [(68)Ga]ABY-025 Affibody PET/CT (2016)
- Feasibility of Multiple Examinations Using Ga-68-Labelled Collagelin Analogues (2016)
- Ga-68/PET imaging and quantification of fibrosis using peptide-based tracers (2016)
- Dynamic scanning, kinetic modelling and parametric images reveal lung inflammation (2016)
- Good manufacturing practice production of [68Ga]Ga-ABY-025 for HER2 specific breast cancer imaging. (2016)
- Validation of parametric net influx rate images of Ga-68-DOTATOC and Ga-68-DOTATATE (2015)
- Non-invasive determination of HER2-expression in metastatic breast cancer by using Ga-68-ABY025 PET/CT. (2015)
- Influence of chelators on targeting properties of In-111 and Ga-68 labeled GRPR antagonist (2015)
- Dosimetry of [(68)Ga]Ga-DO3A-VS-Cys(40)-Exendin-4 in rodents, pigs, non-human primates and human - (2015)
- Accuracy of [Ga-68]ABY-025 PET/CT for determination of HER2-expression in metastatic breast cancer (2015)
- The effect of macrocyclic chelators on the targeting properties of the 68Ga-labeled gastrin releasing peptide receptor antagonist PEG2-RM26 (2015)
- Continued rapid growth in Ga-68 applications (2015)
- Ge-68/Ga-68 generators and tracer production (2015)
- 68Ga-Based radiopharmaceuticals (2015)
- Dosimetry of [(177)Lu]-DO3A-VS-Cys(40)-Exendin-4 - impact on the feasibility of insulinoma internal radiotherapy. (2015)
- Rat organ distribution of [Lu-177]-DO3A-VS-Cys(40)-Exendin-4 for the estimation of human dosimetry (2015)
- Extrapolated dosimetry of two novel Ga-68-labelled imaging agents for fibrosis (2015)
- Dosimetry of [Ga-68]Ga-DO3A-VS-Cys(40)-Exendin-4 in rodents, pigs, non-human primates and human (2015)
- Good manufacturing practice compliant production of a Ga-68-labelled Affibody agent for breast cancer imaging (2015)
- Dosimetry of 68Ga and 177Lu labeled Exendin4-impact on feasibility of repeated PET imaging and radiotherapy (2014)
- Detection of metastatic insulinoma by positron emission tomography with [68Ga]Exendin-4-a case report (2014)
- Detection of Metastatic Insulinoma by Positron Emission Tomography with [(68)Ga]Exendin-4 - (2014)
- Radiation dosimetry and tracer kinetic analysis of Ga-68-ABY025 Affibody in breast cancer patients (2014)
- Influence of chelators on biodistribution and targeting properties of GRPR antagonist (2014)
- Positron emission tomography imaging of the glucagon-like peptide-1 receptor in healthy and streptozotocin-induced diabetic pigs (2014)
- Positron Emission Tomography imaging of the glucagon like peptide-1 receptor in healthy and streptozotocin-induced diabetic pigs (2014)
- PET imaging of the GLP-1 receptor in healthy and streptozotocin-induced diabetic pigs (2014)
- Pre-clinical evaluation of [(68)Ga]Ga-DO3A-VS-Cys(40)-Exendin-4 for imaging of insulinoma (2014)
- Dosimetry of [68Ga]Ga-DO3A-VS-Cys40-Exendin-4 in rat, non-human primate and human (2014)
- Comparison of [68Ga]-DOTA-TOC and [68Ga]-DOTA-TATE (2014)
- Measuring HER2-expression in metastatic breast cancer using 68Ga-ABY025 PET/CT (2014)
- The Effect of Mini-PEG-Based Spacer Length on Binding and Pharmacokinetic Properties of a Ga-68-Labeled NOTA-Conjugated Antagonistic Analog of Bombesin (2014)
- Synthesis and preclinical evaluation of Ga-68-labeled collagelin analogs for imaging and quantification of fibrosis (2014)
- Quantitative and Qualitative Intrapatient Comparison of 68Ga-DOTATOC and 68Ga-DOTATATE (2014)
- GMP compliant preparation of a (68)Gallium-labeled Affibody analogue for breast cancer patient examination (2014)
- Comparative Biodistribution and Radiation Dosimetry of Ga-68-DOTATOC and Ga-68-DOTATATE in Patients with Neuroendocrine Tumors (2013)
- In Vivo Imaging of the Glucagonlike Peptide 1 Receptor in the Pancreas with Ga-68-Labeled DO3A-Exendin-4 (2013)
- Synthesis and Characterization of a High-Affinity NOTA-Conjugated Bombesin Antagonist for GRPR-Targeted Tumor Imaging (2013)
- GRPR antagonist NOTA-P2-RM26 labeled with fluorine-18 (2013)
- In Vitro and In Vivo Evaluation of a F-18-Labeled High Affinity NOTA Conjugated Bombesin Antagonist as a PET Ligand for GRPR-Targeted Tumor Imaging (2013)
- The diversity of (68)Ga-based imaging agents (2013)
- Prospective of ⁶⁸Ga-radiopharmaceutical development (2013)
- Organ biodistribution of Germanium-68 in rat in the presence and absence of [68Ga]Ga-DOTA-TOC for the extrapolation to the human organ and whole-body radiation dosimetry (2013)
- Organ biodistribution of Germanium-68 in rat in the presence and absence of [Ga-68]Ga-DOTA-TOC for the extrapolation to the human organ and whole-body radiation dosimetry (2013)
- Synthesis and preclinical evaluation of Ga-68-labelled collagelin analogues for imaging and quantification of fibrosis (2013)
- Comparison of radiation dosimetry of [Ga-68]Ga-DOTA-TOC and [Ga-68]Ga-DOTA-TATE in patients affected by neuroendocrine tumours (2013)
- Ga-68-labelling of Exendin-4, preclinical evaluation of the resultant tracer for the imaging and quantification of insulinomas, and case patient examination (2013)
- Ga-68-Labeling of RGD peptides and biodistribution (2012)
- 68Ga-Labeling of RGD peptides and biodistribution (2012)
- Preclinical evaluation of a 68Ga-labeled biotin analogue for applications in islet transplantation (2012)
- In vitro autoradiography of carcinoembryonic antigen in tissue from patients with colorectal cancer using multifunctional antibody TF2 and 67/68Ga-labeled haptens by pretargeting (2012)
- Pancreatic uptake of [68Ga]DO3A-Exendin4 is mediated by the GLP-1 receptor (2012)
- Synthesis and characterization of a high affinity NOTA-conjugated bombesin antagonist for GRPR-targeted tumor imaging (2012)
- Molecular Imaging and Radiotherapy (2012)
- One pot preparation of Ga-68-labelled macroaggregated albumin for PET-imaging of acute pulmonary embolism and myocardial perfusion quantification (2012)
- Robust labeling and comparative preclinical characterization of DOTA-TOC and DOTA-TATE (2012)
- Synthesis and characterization of scVEGF-PEG-[68Ga]NOTA and scVEGF-PEG-[68Ga]DOTA PET tracers (2011)
- Ventilation Distribution Studies Comparing Technegas and "Gallgas" Using (GaCl3)-Ga-68 as the Label (2011)
- Improved Tumor-to-Organ Ratios of a Novel 67Ga-Human Epidermal Growth Factor Radionuclide Conjugate with Preadministered Antiepidermal Growth Factor Receptor Affibody Molecules (2011)
- Positron Emitting [Ga-68]Ga-Based Imaging Agents (2011)
- A HER2-binding Affibody molecule labelled with 68Ga for PET imaging (2010)
- In vivo binding of [68Ga]-DOTATOC to somatostatin receptors in neuroendocrine tumours — impact of peptide mass (2010)
- Imaging biomarkers for diagnosis and quantification with positron emission tomography (2010)
- 68Ga-Labeling of Biotin Analogues and their Characterization (2009)
- Convenient preparation of 68Ga-based PET-radiopharmaceuticals at room temperature. (2008)
- Polyamine deactivation of integrated poly(dimethylsiloxane) structures investigated by radionuclide imaging and capillary electrophoresis experiments (2005)
- Biodistribution of 68Ga-labelled phosphodiester, phosphorothioate, and 2'-O-methyl phosphodiester oligonucleotides in normal rats (2005)
- Preparation and evaluation of (68)Ga-DOTA-hEGF for visualisation of EGFR expression in malignant tumours (2005)
- Radionuclide Imaging of Miniaturized Chemical Analysis Systems (2004)
- Microwave-supported preparation of 68Ga-bioconjugates with high specific radioactivity (2004)
- Microwave-Supported Prepatarion of 68Ga Bioconjugates with High Specific Radioactivity (2004)
- Microwave accelerated 68Ga-labelling of oliqonucleotides (2004)
- Microwave accelerated 68Ga-labelling of oligonucleotides (2004)
- The pKa’s of 2'-Hydroxyl Group in Nucleosides and Nucleotides (2001)
- Comparison of 68Ga-DOTATATE and 177Lu-DOTATATE kinetics in neuroendocrine tumors
- Imaging of peptide adsorption to microfluidic channels in a plastic compact disc using a positron emitting radionuclide
- Investigating inflammation and tissue remodeling in ILD with [11C]NES and [68Ga]Ga-FAPI-46 PET imaging
- Exploring impacts of long-COVID-19 on the lungs: A triad of PET scans for perfusion, inflammation and tissue remodeling
Chapters
