Caroline Fronczak Alvebratt
Researcher at Department of Pharmacy; Molecular Pharmaceutics
- E-mail:
- caroline.alvebratt@uu.se
- Visiting address:
- Biomedicinskt Centrum BMC, Husargatan 3
- Postal address:
- Box 580
751 23 UPPSALA
Keywords
- Advanced drug delivery systems
- Lipid-based formulations
- dissolution and digestion
- in vitro models
Research
My research aims to improve how modern drug delivery systems are designed, evaluated, and translated toward effective in vivo performance - especially for challenging, poorly soluble compounds. I investigate how the physicochemical properties of both active pharmaceutical ingredients and excipients, along with their interactions, affect drug performance. A key aspect of my work involves developing more biorelevant in vitro models to better predict in vivo outcomes and support the design of effective formulation strategies.

Publications
Recent publications
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Benefits of combining supersaturating and solubilizing formulations - Is two better than one?
Part of International Journal of Pharmaceutics, 2024
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Advanced Methods for Evaluation of the Performance of Complex Drug Delivery System
2021
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Part of Pharmaceutics, 2020
- DOI for In Vitro Performance and Chemical Stability of Lipid-Based Formulations Encapsulated in a Mesoporous Magnesium Carbonate Carrier
- Download full text (pdf) of In Vitro Performance and Chemical Stability of Lipid-Based Formulations Encapsulated in a Mesoporous Magnesium Carbonate Carrier
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An in vitro dissolution–digestion–permeation assay for the study of advanced drug delivery systems
Part of European journal of pharmaceutics and biopharmaceutics, p. 21-29, 2020
- DOI for An in vitro dissolution–digestion–permeation assay for the study of advanced drug delivery systems
- Download full text (pdf) of An in vitro dissolution–digestion–permeation assay for the study of advanced drug delivery systems
-
Advanced methodologies to study in vitro digestion of a lipid-loaded mesoporous drug carrier
Part of Preclinical Form and Formulation for Drug Discovery, Gordon Research Conference 2019, 2019
All publications
Articles in journal
-
Benefits of combining supersaturating and solubilizing formulations - Is two better than one?
Part of International Journal of Pharmaceutics, 2024
-
Part of Pharmaceutics, 2020
- DOI for In Vitro Performance and Chemical Stability of Lipid-Based Formulations Encapsulated in a Mesoporous Magnesium Carbonate Carrier
- Download full text (pdf) of In Vitro Performance and Chemical Stability of Lipid-Based Formulations Encapsulated in a Mesoporous Magnesium Carbonate Carrier
-
An in vitro dissolution–digestion–permeation assay for the study of advanced drug delivery systems
Part of European journal of pharmaceutics and biopharmaceutics, p. 21-29, 2020
- DOI for An in vitro dissolution–digestion–permeation assay for the study of advanced drug delivery systems
- Download full text (pdf) of An in vitro dissolution–digestion–permeation assay for the study of advanced drug delivery systems
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Part of AAPS PharmSciTech, p. 2859-2865, 2018
- DOI for A Modified In Situ Method to Determine Release from a Complex Drug Carrier in Particle-Rich Suspensions
- Download full text (pdf) of A Modified In Situ Method to Determine Release from a Complex Drug Carrier in Particle-Rich Suspensions
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Part of International Journal of Pharmaceutics, p. 515-521, 2018
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Part of International Journal of Pharmaceutics, p. 183-190, 2017
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Part of Pharmaceutical research, p. 1805-1816, 2017
- DOI for Controlled Suspensions Enable Rapid Determinations of Intrinsic Dissolution Rate and Apparent Solubility of Poorly Water-Soluble Compounds
- Download full text (pdf) of Controlled Suspensions Enable Rapid Determinations of Intrinsic Dissolution Rate and Apparent Solubility of Poorly Water-Soluble Compounds
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Part of Journal of Pharmaceutical Sciences, p. 2864-2872, 2016
Comprehensive doctoral thesis
Conference papers
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Advanced methodologies to study in vitro digestion of a lipid-loaded mesoporous drug carrier
Part of Preclinical Form and Formulation for Drug Discovery, Gordon Research Conference 2019, 2019
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Synthesis of amorphous magnesium carbonate nanoparticles for biomedical applications
Part of Bioceramics 29 ISCM 2017, 2017
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A new method that enables in situ measurement of drug release from complex carrier-mediated systems
Part of 6th FIP Pharmaceutical Sciences World Congress2017., 2017
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Part of pION Fiber Optic Advanced Training Course. Uppsala, June 14-15, 2016., 2016
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A small scale method to determine release rate from complex carrier-mediated systems
Part of Emerging Technologies in Drug Discovery and Development. Zhuhai, August 23-26, 2016., 2016