Maria Letizia Di Martino
Researcher Docent at Department of Medical Biochemistry and Microbiology; Infection and Immunity; Mikael Sellin
- E-mail:
- ml.dimartino@imbim.uu.se
- Visiting address:
- BMC
Husargatan 3
752 37 UPPSALA - Postal address:
- Box 582
751 23 UPPSALA
- ORCID:
- 0000-0002-9491-4000
Short presentation
I am an Associate Professor (Docent) at Uppsala University where I lead research at the intersection of bacterial genetics, molecular microbiology, and advanced tissue culture. My work focuses on unraveling the complexities of host-pathogen interactions through cutting-edge intestinal organoid models and functional genomics approaches.
Biography
Degrees and Merits
- 2026 - Associate Professor (Docent) in Microbiology, Uppsala University.
- 2024 - National Scientific Qualification (Abilitazione Scientifica Nazionale - ASN) as Associate Professor (Docent) in the Italian higher education system for the disciplinary field of 05/I2 - MICROBIOLOGY. Validity: From 2024-09-16 to 2036-09-16.
- 2011 - PhD in Cell and Developmental Biology, Doctoral thesis in Microbiology - Sapienza University of Rome, Italy.
Grants
- 2023 – 2025 ǀ Carl Tryggers Stiftelse ǀ The fitness landscape of Shigella flexneri at the transition between environmental and host-colonizing lifestyles.
- 2021 ǀ Clas Groschinsky Minnesfond ǀ TraDIShigella: Revealing the Shigella flexneri epithelial invasome in a human enteroid infection model.
- 2020 ǀ ESCMID (European Society for Medical Microbiology and Infectious Diseases) ǀ Revealing the Shigella flexneri epithelial invasome in a human enteroid infection model.
- 2019 – 2021 ǀ Carl Tryggers Stiftelse ǀ VirF21: a negative regulator of the Shigella life style switching.
- 2014 ǀ Sapienza University of Rome ǀ Training Abroad Postdoctoral Fellowship – Group of Gerhart Wagner, Uppsala University.
- 2013 ǀ FEMS Visiting Postdoctoral Fellowship ǀ Institut Pasteur, Paris, France – Group of Didier Mazel.
Distinctions and awards
- 2017 ǀ Giovanni Magni Award 2017 for the best paper in Molecular Microbiology (Di Martino et al, 2016 – mBio).
- 2012 ǀ SIMGBM - Franco Tatò 2012 Award for the best PhD thesis in General Microbiology.
Media
https://www.linkedin.com/in/maria-letizia-di-martino-ba112047/
Google Scholar
https://scholar.google.ch/citations?user=De67mN4AAAAJ&hl=en
ORCID

Publications
Recent publications
The pcnB gene sustains Shigella flexneri virulence
Part of PLoS Pathogens, 2025
- DOI for The pcnB gene sustains Shigella flexneri virulence
- Download full text (pdf) of The pcnB gene sustains Shigella flexneri virulence
Part of Cell Reports, 2025
- DOI for Maturation of Human Intestinal Epithelial Cell Layers Fortifies the Apical Surface against Salmonella Attack
- Download full text (pdf) of Maturation of Human Intestinal Epithelial Cell Layers Fortifies the Apical Surface against Salmonella Attack
Part of Nature Genetics, p. 1730-1741, 2025
Part of mBio, p. 1-22, 2025
- DOI for Determinants of divergent Salmonella and Shigella epithelial colonization strategies resolved in human enteroids and colonoids
- Download full text (pdf) of Determinants of divergent Salmonella and Shigella epithelial colonization strategies resolved in human enteroids and colonoids
Part of Nature Communications, 2024
- DOI for A two-step activation mechanism enables mast cells to differentiate their response between extracellular and invasive enterobacterial infection
- Download full text (pdf) of A two-step activation mechanism enables mast cells to differentiate their response between extracellular and invasive enterobacterial infection
All publications
Articles in journal
The pcnB gene sustains Shigella flexneri virulence
Part of PLoS Pathogens, 2025
- DOI for The pcnB gene sustains Shigella flexneri virulence
- Download full text (pdf) of The pcnB gene sustains Shigella flexneri virulence
Part of Cell Reports, 2025
- DOI for Maturation of Human Intestinal Epithelial Cell Layers Fortifies the Apical Surface against Salmonella Attack
- Download full text (pdf) of Maturation of Human Intestinal Epithelial Cell Layers Fortifies the Apical Surface against Salmonella Attack
Part of Nature Genetics, p. 1730-1741, 2025
Part of mBio, p. 1-22, 2025
- DOI for Determinants of divergent Salmonella and Shigella epithelial colonization strategies resolved in human enteroids and colonoids
- Download full text (pdf) of Determinants of divergent Salmonella and Shigella epithelial colonization strategies resolved in human enteroids and colonoids
Part of Nature Communications, 2024
- DOI for A two-step activation mechanism enables mast cells to differentiate their response between extracellular and invasive enterobacterial infection
- Download full text (pdf) of A two-step activation mechanism enables mast cells to differentiate their response between extracellular and invasive enterobacterial infection
Part of Chemical Science, p. 5291-5301, 2023
- DOI for Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites
- Download full text (pdf) of Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites
Part of FEMS Microbiology Letters, 2022
- DOI for The VirF(21):VirF(30) protein ratio is affected by temperature and impacts Shigella flexneri host cell invasion
- Download full text (pdf) of The VirF(21):VirF(30) protein ratio is affected by temperature and impacts Shigella flexneri host cell invasion
Part of Molecular Microbiology, p. 1156-1172, 2022
- DOI for A motile doublet form of Salmonella Typhimurium diversifies target search behavior at the epithelial surface
- Download full text (pdf) of A motile doublet form of Salmonella Typhimurium diversifies target search behavior at the epithelial surface
Part of mBio, 2021
- DOI for Salmonella enterica Serovar Typhimurium Exploits Cycling through Epithelial Cells To Colonize Human and Murine Enteroids
- Download full text (pdf) of Salmonella enterica Serovar Typhimurium Exploits Cycling through Epithelial Cells To Colonize Human and Murine Enteroids
Bacterial detection by NAIP/NLRC4 elicits prompt contractions of intestinal epithelial cell layers
Part of Proceedings of the National Academy of Sciences of the United States of America, 2021
- DOI for Bacterial detection by NAIP/NLRC4 elicits prompt contractions of intestinal epithelial cell layers
- Download full text (pdf) of Bacterial detection by NAIP/NLRC4 elicits prompt contractions of intestinal epithelial cell layers
Part of Mucosal Immunology, p. 615-629, 2021
- DOI for Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice
- Download full text (pdf) of Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice
Salmonella Typhimurium discreet-invasion of the murine gut absorptive epithelium
Part of PLoS Pathogens, 2020
- DOI for Salmonella Typhimurium discreet-invasion of the murine gut absorptive epithelium
- Download full text (pdf) of Salmonella Typhimurium discreet-invasion of the murine gut absorptive epithelium
Part of mBio, 2019
- DOI for Barcoded Consortium Infections Resolve Cell Type-Dependent Salmonella enterica Serovar Typhimurium Entry Mechanisms
- Download full text (pdf) of Barcoded Consortium Infections Resolve Cell Type-Dependent Salmonella enterica Serovar Typhimurium Entry Mechanisms
Articles, review/survey
The Intriguing Evolutionary Journey of Enteroinvasive E-coli (EIEC) toward Pathogenicity
Part of Frontiers in Microbiology, 2017
- DOI for The Intriguing Evolutionary Journey of Enteroinvasive E-coli (EIEC) toward Pathogenicity
- Download full text (pdf) of The Intriguing Evolutionary Journey of Enteroinvasive E-coli (EIEC) toward Pathogenicity
Chapters in book
Part of Bacterial Pathogenesis, p. 295-311, Humana Press, 2023