Sebastian Westenhoff
Professor at Department of Chemistry - BMC; Biochemistry; Westenhoff group
- Telephone:
- +46 18 471 54 99
- Mobile phone:
- +46 76 618 39 36
- E-mail:
- sebastian.westenhoff@kemi.uu.se
- Visiting address:
- Husargatan 3
752 37 Uppsala - Postal address:
- Box 576
75123 Uppsala
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Short presentation
The Westenhoff group studies protein structural dynamics at ultrashort time scales in order to understand elementary biochemical reactions. We use and develop cutting edge methods in time-resolved crystallography at X-ray Free Electron lasers, single-particle cryo EM, and protein prediction by artificial intelligence. We study phytochrome proteins (detection of light in plants and bacteria), photolyases (DNA repair), and proteins in the circadian clock.
Biography
PhD, University of Cambridge
MSc, Lund University
Publications
Recent publications
- Directed ultrafast conformational changes accompany electron transfer in a photolyase as resolved by serial crystallography (2024)
- Time-resolved serial crystallography to reveal protein structural changes (2024)
- Ground-state heterogeneity and vibrational energy redistribution in bacterial phytochrome observed with femtosecond 2D IR spectroscopy (2023)
- 3D-printed sheet jet for stable megahertz liquid sample delivery at X-ray free-electron lasers (2023)
- Structural basis of the radical pair state in photolyases and cryptochromes (2022)
All publications
Articles
- Directed ultrafast conformational changes accompany electron transfer in a photolyase as resolved by serial crystallography (2024)
- Time-resolved serial crystallography to reveal protein structural changes (2024)
- Ground-state heterogeneity and vibrational energy redistribution in bacterial phytochrome observed with femtosecond 2D IR spectroscopy (2023)
- 3D-printed sheet jet for stable megahertz liquid sample delivery at X-ray free-electron lasers (2023)
- Structural basis of the radical pair state in photolyases and cryptochromes (2022)
- Structural mechanism of signal transduction in a phytochrome histidine kinase (2022)
- Protein motions visualized by femtosecond time-resolved crystallography (2022)
- Directed ultrafast conformational changes accompany electrontransfer in a photolyase as resolved by serial crystallography
- Microsecond time-resolved X-ray scattering by utilizing MHz repetition rate at second-generation XFELs
- Refolding of the Deinococcus Radiodurans phytochrome photosensory module and backbone resonance assignment by solution NMR
- Insight into signaling mechanism of the Deinococcus Radiodurans phytochrome chromophore binding core
