Sebastian Westenhoff
Professor at Department of Chemistry - BMC; Biochemistry; Westenhoff group
- Telephone:
- +46 18 471 54 99
- Mobile phone:
- +46 76 618 39 36
- E-mail:
- sebastian.westenhoff@kemi.uu.se
- Visiting address:
- Husargatan 3
752 37 Uppsala - Postal address:
- Box 576
75123 Uppsala
Short presentation
The Westenhoff group studies protein structural dynamics at ultrashort time scales in order to understand elementary biochemical reactions. We use and develop cutting edge methods in time-resolved crystallography at X-ray Free Electron lasers, single-particle cryo EM, and protein prediction by artificial intelligence. We study phytochrome proteins (detection of light in plants and bacteria), photolyases (DNA repair), and proteins in the circadian clock.
Biography
PhD, University of Cambridge
MSc, Lund University
Publications
Recent publications
Part of Protein Expression and Purification, 2025
- DOI for Refolding of the Deinococcus Radiodurans phytochrome photosensory module and backbone resonance assignment by solution NMR
- Download full text (pdf) of Refolding of the Deinococcus Radiodurans phytochrome photosensory module and backbone resonance assignment by solution NMR
Part of Nature Methods, p. 1608-1611, 2024
- DOI for Microsecond time-resolved X-ray scattering by utilizing MHz repetition rate at second-generation XFELs
- Download full text (pdf) of Microsecond time-resolved X-ray scattering by utilizing MHz repetition rate at second-generation XFELs
Part of Structure, p. 1952-1962000, 2024
- DOI for Cryo-EM structures of a bathy phytochrome histidine kinase reveal a unique light-dependent activation mechanism
- Download full text (pdf) of Cryo-EM structures of a bathy phytochrome histidine kinase reveal a unique light-dependent activation mechanism
Part of Nature Chemistry, p. 624-632, 2024
- DOI for Directed ultrafast conformational changes accompany electron transfer in a photolyase as resolved by serial crystallography
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Time-resolved serial crystallography to reveal protein structural changes
Part of Trends in Biochemical Sciences (TIBS), p. 183-184, 2024
- DOI for Time-resolved serial crystallography to reveal protein structural changes
- Download full text (pdf) of Time-resolved serial crystallography to reveal protein structural changes
All publications
Articles in journal
Part of Protein Expression and Purification, 2025
- DOI for Refolding of the Deinococcus Radiodurans phytochrome photosensory module and backbone resonance assignment by solution NMR
- Download full text (pdf) of Refolding of the Deinococcus Radiodurans phytochrome photosensory module and backbone resonance assignment by solution NMR
Part of Nature Methods, p. 1608-1611, 2024
- DOI for Microsecond time-resolved X-ray scattering by utilizing MHz repetition rate at second-generation XFELs
- Download full text (pdf) of Microsecond time-resolved X-ray scattering by utilizing MHz repetition rate at second-generation XFELs
Part of Structure, p. 1952-1962000, 2024
- DOI for Cryo-EM structures of a bathy phytochrome histidine kinase reveal a unique light-dependent activation mechanism
- Download full text (pdf) of Cryo-EM structures of a bathy phytochrome histidine kinase reveal a unique light-dependent activation mechanism
Part of Nature Chemistry, p. 624-632, 2024
- DOI for Directed ultrafast conformational changes accompany electron transfer in a photolyase as resolved by serial crystallography
- Download full text (pdf) of Directed ultrafast conformational changes accompany electron transfer in a photolyase as resolved by serial crystallography
Time-resolved serial crystallography to reveal protein structural changes
Part of Trends in Biochemical Sciences (TIBS), p. 183-184, 2024
- DOI for Time-resolved serial crystallography to reveal protein structural changes
- Download full text (pdf) of Time-resolved serial crystallography to reveal protein structural changes
3D-printed sheet jet for stable megahertz liquid sample delivery at X-ray free-electron lasers
Part of IUCrJ, p. 662-670, 2023
- DOI for 3D-printed sheet jet for stable megahertz liquid sample delivery at X-ray free-electron lasers
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Part of Journal of Chemical Physics, 2023
- DOI for Ground-state heterogeneity and vibrational energy redistribution in bacterial phytochrome observed with femtosecond 2D IR spectroscopy
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Structural basis of the radical pair state in photolyases and cryptochromes
Part of Chemical Communications, p. 4889-4892, 2022
- DOI for Structural basis of the radical pair state in photolyases and cryptochromes
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Part of Current opinion in structural biology, 2022
- DOI for Protein motions visualized by femtosecond time-resolved crystallography: The case of photosensory vs photosynthetic proteins
- Download full text (pdf) of Protein motions visualized by femtosecond time-resolved crystallography: The case of photosensory vs photosynthetic proteins
Structural mechanism of signal transduction in a phytochrome histidine kinase
Part of Nature Communications, 2022
- DOI for Structural mechanism of signal transduction in a phytochrome histidine kinase
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