Alina Meyer
PhD student at Department of Pharmacy; Drug Delivery
- E-mail:
- alina.meyer@uu.se
- Visiting address:
- Biomedicinskt Centrum BMC, Husargatan 3
- Postal address:
- Box 580
751 23 UPPSALA
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Keywords
- adme
- adpkd
- drug discovery
- drug repurposing
- drugtrain
- kidney disease
- organoids
- pkpd
Research
The general aim of my PhD thesis is to pharmaceutically profile new repurposing candidates for the treatment of the hereditary kidney disease ADPKD. I will perform a series of ADME assays. Then, the intracellular compound concentration and the corresponding pharmacological effect will be investigated using 3D cultured kidney organoids and global proteomics. Furthermore, subcellular target and off-target interaction for lead candidates will be studied and the findings will be combined in a PBPK model.
The project is part of the EU 'DRUGtrain' network.
