Alina Meyer
PhD student at Department of Pharmacy; Molecular Pharmaceutics
- E-mail:
- alina.meyer@uu.se
- Visiting address:
- Biomedicinskt Centrum BMC, Husargatan 3
- Postal address:
- Box 580
751 23 UPPSALA
Download contact information for Alina Meyer at Department of Pharmacy; Molecular Pharmaceutics
Keywords
- pkpd
- organoids
- adme
- drug discovery
- adpkd
- drug repurposing
- kidney disease
- drugtrain
Research
The general aim of my PhD thesis is to pharmaceutically profile new repurposing candidates for the treatment of the hereditary kidney disease ADPKD. I will perform a series of ADME assays. Then, the intracellular compound concentration and the corresponding pharmacological effect will be investigated using 3D cultured kidney organoids and global proteomics. Furthermore, subcellular target and off-target interaction for lead candidates will be studied and the findings will be combined in a PBPK model.
The project is part of the EU 'DRUGtrain' network.
Publications
Recent publications
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Insights into Polycystic Kidney Disease: In Vitro Models, Proteome Analyses and Drug Repurposing
2025
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Part of Clinical and Translational Science, 2025
- DOI for A Patient-Derived 3D Cyst Model of Polycystic Kidney Disease That Mimics Disease Development and Responds to Repurposing Candidates
- Download full text (pdf) of A Patient-Derived 3D Cyst Model of Polycystic Kidney Disease That Mimics Disease Development and Responds to Repurposing Candidates
-
Part of Environmental Toxicology and Pharmacology, 2025
- DOI for The intracellular free concentration of endocrine disrupting chemicals enables translation between cell-free and cell-based estrogenic activity assays
- Download full text (pdf) of The intracellular free concentration of endocrine disrupting chemicals enables translation between cell-free and cell-based estrogenic activity assays
-
OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids
Part of Scientific Reports, 2024
- DOI for OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids
- Download full text (pdf) of OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids
All publications
Articles in journal
-
Part of Clinical and Translational Science, 2025
- DOI for A Patient-Derived 3D Cyst Model of Polycystic Kidney Disease That Mimics Disease Development and Responds to Repurposing Candidates
- Download full text (pdf) of A Patient-Derived 3D Cyst Model of Polycystic Kidney Disease That Mimics Disease Development and Responds to Repurposing Candidates
-
Part of Environmental Toxicology and Pharmacology, 2025
- DOI for The intracellular free concentration of endocrine disrupting chemicals enables translation between cell-free and cell-based estrogenic activity assays
- Download full text (pdf) of The intracellular free concentration of endocrine disrupting chemicals enables translation between cell-free and cell-based estrogenic activity assays
-
OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids
Part of Scientific Reports, 2024
- DOI for OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids
- Download full text (pdf) of OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids