Andrew Hooker

The Role of Model Master Files for Sharing, Acceptance, and Communication with FDA

Fang, Lanyan; Gong, Yuqing; Hooker, Andrew; Lukacova, Viera et al.

Part of AAPS Journal, 2024

• DOI for The Role of Model Master Files for Sharing, Acceptance, and Communication with FDA

Statistical recommendations for count, binary, and ordinal data in rare disease cross-over trials

Geroldinger, Martin; Verbeeck, Johan; Hooker, Andrew C.; Thiel, Konstantin E. et al.

Part of Orphanet Journal of Rare Diseases, 2023

• DOI for Statistical recommendations for count, binary, and ordinal data in rare disease cross-over trials
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Establishing the suitability of model-integrated evidence to demonstrate bioequivalence for long-acting injectable and implantable drug products: Summary of workshop

Gong, Yuqing; Zhang, Peijue; Yoon, Miyoung; Zhu, Hao et al.

Part of CPT, p. 624-630, 2023

• DOI for Establishing the suitability of model-integrated evidence to demonstrate bioequivalence for long-acting injectable and implantable drug products: Summary of workshop
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Bounded Integer Modeling of Symptom Scales Specific to Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia

Lyauk, Yassine Kamal; Jonker, Daniel M.; Hooker, Andrew; Lund, Trine Meldgaard et al.

Part of AAPS Journal, 2021

• DOI for Bounded Integer Modeling of Symptom Scales Specific to Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia
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Pharmacometrics meets statistics-A synergy for modern drug development

Ryeznik, Yevgen; Sverdlov, Oleksandr; Svensson, Elin; Montepiedra, Grace et al.

Part of CPT, p. 1134-1149, 2021

• DOI for Pharmacometrics meets statistics-A synergy for modern drug development
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Metaheuristics for pharmacometrics

Kim, Seongho; Hooker, Andrew; Shi, Yu; Kim, Grace Hyun J. et al.

Part of CPT, p. 1297-1309, 2021

• DOI for Metaheuristics for pharmacometrics
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Tutorial for $DESIGN in NONMEM: Clinical trial evaluation and optimization

Bauer, Robert J.; Hooker, Andrew; Mentre, France

Part of CPT, p. 1452-1465, 2021

• DOI for Tutorial for $DESIGN in NONMEM: Clinical trial evaluation and optimization
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Public Workshop Summary Report on Fiscal Year 2021 Generic Drug Regulatory Science Initiatives: Data Analysis and Model-Based Bioequivalence.

Lee, Jieon; Gong, Yuqing; Bhoopathy, Sid; DiLiberti, Charles E et al.

Part of Clinical Pharmacology and Therapeutics, p. 1190-1195, 2021

• DOI for Public Workshop Summary Report on Fiscal Year 2021 Generic Drug Regulatory Science Initiatives: Data Analysis and Model-Based Bioequivalence.
• Download full text (pdf) of Public Workshop Summary Report on Fiscal Year 2021 Generic Drug Regulatory Science Initiatives: Data Analysis and Model-Based Bioequivalence.

Model-Informed Drug Development for Long-Acting Injectable Products: Summary of American College of Clinical Pharmacology Symposium

Sharan, Satish; Fang, Lanyan; Lukacova, Viera; Chen, Xiaomei et al.

Part of Clinical Pharmacology in Drug Development, p. 220-228, 2021

• DOI for Model-Informed Drug Development for Long-Acting Injectable Products: Summary of American College of Clinical Pharmacology Symposium

Item Response Theory Modeling of the International Prostate Symptom Score in Patients with Lower Urinary Tract Symptoms Associated with Benign Prostatic Hyperplasia

Lyauk, Yassine Kamal; Jonker, Daniel M.; Lund, Trine Meldgaard; Hooker, Andrew et al.

Part of AAPS Journal, 2020

• DOI for Item Response Theory Modeling of the International Prostate Symptom Score in Patients with Lower Urinary Tract Symptoms Associated with Benign Prostatic Hyperplasia
• Download full text (pdf) of Item Response Theory Modeling of the International Prostate Symptom Score in Patients with Lower Urinary Tract Symptoms Associated with Benign Prostatic Hyperplasia

Population Pharmacokinetics and Dosing of Ethionamide in Children with Tuberculosis

Bjugård Nyberg, Henrik; Draper, Heather R.; Garcia-Prats, Anthony J.; Thee, Stephanie et al.

Part of Antimicrobial Agents and Chemotherapy, 2020

• DOI for Population Pharmacokinetics and Dosing of Ethionamide in Children with Tuberculosis

Saddle-Reset for Robust Parameter Estimation and Identifiability Analysis of Nonlinear Mixed Effects Models

Bjugård Nyberg, Henrik; Hooker, Andrew C.; Bauer, Robert J; Aoki, Yasunori

Part of AAPS Journal, 2020

• DOI for Saddle-Reset for Robust Parameter Estimation and Identifiability Analysis of Nonlinear Mixed Effects Models
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Optimizing Dose-Finding Studies for Drug Combinations Based on Exposure-Response Models

Papathanasiou, Theodoros; Strathe, Anders; Overgaard, Rune Viig; Lund, Trine Meldgaard et al.

Part of AAPS Journal, 2019

• DOI for Optimizing Dose-Finding Studies for Drug Combinations Based on Exposure-Response Models

Feasibility of Exposure-Response Analyses for Clinical Dose-Ranging Studies of Drug Combinations

Papathanasiou, Theodoros; Strathe, Anders; Hooker, Andrew C.; Lund, Trine Meldgaard et al.

Part of AAPS Journal, 2018

• DOI for Feasibility of Exposure-Response Analyses for Clinical Dose-Ranging Studies of Drug Combinations

Adaptive Optimal Designs for Dose-Finding Studies with Time-to-Event Outcomes

Ryeznik, Yevgen; Sverdlov, Oleksandr; Hooker, Andrew C

Part of AAPS Journal, 2018

• DOI for Adaptive Optimal Designs for Dose-Finding Studies with Time-to-Event Outcomes
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A Population Pharmacokinetic-Pharmacodynamic Model of Pegfilgrastim

Brekkan, Ari; Lopez-Lazaro, Luis; Yngman, Gunnar; Plan, Elodie L. et al.

Part of AAPS Journal, 2018

• DOI for A Population Pharmacokinetic-Pharmacodynamic Model of Pegfilgrastim
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Implementing Optimal Designs for Dose-Response Studies Through Adaptive Randomization for a Small Population Group

Ryeznik, Yevgen; Sverdlov, Oleksandr; Hooker, Andrew

Part of AAPS Journal, 2018

• DOI for Implementing Optimal Designs for Dose-Response Studies Through Adaptive Randomization for a Small Population Group
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Model-Based Adaptive Optimal Design (MBAOD) Improves Combination Dose Finding Designs: an Example in Oncology

Pierrillas, Philippe B.; Fouliard, Sylvain; Chenel, Marylore; Hooker, Andrew et al.

Part of AAPS Journal, 2018

• DOI for Model-Based Adaptive Optimal Design (MBAOD) Improves Combination Dose Finding Designs: an Example in Oncology
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Reduced and optimized trial designs for drugs described by a target mediated drug disposition model

Brekkan, Ari; Jönsson, Siv; Karlsson, Mats O; Hooker, Andrew

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 637-647, 2018

• DOI for Reduced and optimized trial designs for drugs described by a target mediated drug disposition model
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Model-Informed Drug Development and Review for Generic Products: Summary Of FDA Public Workshop

Fang, Lanyan; Kim, Myong-Jin; Li, Zhichuan; Wang, Yaning et al.

Part of Clinical Pharmacology and Therapeutics, p. 27-30, 2018

• DOI for Model-Informed Drug Development and Review for Generic Products: Summary Of FDA Public Workshop

Advanced Methods for Dose and Regimen Finding During Drug Development: Summary of the EMA/EFPIA Workshop on Dose Finding (London 4-5 December 2014)

Musuamba, F. T.; Manolis, E.; Holford, N.; Cheung, S. Y. A. et al.

Part of CPT, p. 418-429, 2017

• DOI for Advanced Methods for Dose and Regimen Finding During Drug Development: Summary of the EMA/EFPIA Workshop on Dose Finding (London 4-5 December 2014)

Model Evaluation of Continuous Data Pharmacometric Models: Metrics and Graphics

Nguyen, T. H. T.; Mouksassi, M-S; Holford, N.; Al-Huniti, N. et al.

Part of CPT, p. 87-109, 2017

• DOI for Model Evaluation of Continuous Data Pharmacometric Models: Metrics and Graphics
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Assessing robustness of designs for random effects parameters for nonlinear mixed-effects models

Duffull, Stephen B.; Hooker, Andrew

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 611-616, 2017

• DOI for Assessing robustness of designs for random effects parameters for nonlinear mixed-effects models

Model selection and averaging of nonlinear mixed-effect models for robust phase III dose selection

Aoki, Yasunori; Roshammar, Daniel; Hamren, Bengt; Hooker, Andrew

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 581-597, 2017

• DOI for Model selection and averaging of nonlinear mixed-effect models for robust phase III dose selection
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The effect of using a robust optimality criterion in model based adaptive optimization.

Strömberg, Eric; Hooker, Andrew

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 317-324, 2017

• DOI for The effect of using a robust optimality criterion in model based adaptive optimization.
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Preconditioning of Nonlinear Mixed Effects Models for Stabilisation of Variance-Covariance Matrix Computations

Aoki, Yasunori; Nordgren, Rikard; Hooker, Andrew C.

Part of AAPS Journal, p. 505-518, 2016

• DOI for Preconditioning of Nonlinear Mixed Effects Models for Stabilisation of Variance-Covariance Matrix Computations

Accelerating Monte Carlo power studies through parametric power estimation

Ueckert, Sebastian; Karlsson, Mats O.; Hooker, Andrew C

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 223-234, 2016

• DOI for Accelerating Monte Carlo power studies through parametric power estimation
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Improved precision of exposure-response relationships by optimal dose-selection. Examples from studies of receptor occupancy using PET and dose finding for neuropathic pain treatment

Kågedal, Matts; Karlsson, Mats; Hooker, Andrew C

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 211-224, 2015

• DOI for Improved precision of exposure-response relationships by optimal dose-selection. Examples from studies of receptor occupancy using PET and dose finding for neuropathic pain treatment

Methods and software tools for design evaluation for population pharmacokinetics-pharmacodynamics studies

Nyberg, Joakim; Bazzoli, Caroline; Ogungbenro, Kay; Aliev, Alexander et al.

Part of British Journal of Clinical Pharmacology, p. 6-17, 2015

• DOI for Methods and software tools for design evaluation for population pharmacokinetics-pharmacodynamics studies

Optimal clinical trial design based on a dichotomous Markov-chain mixed-effect sleep model

Ernest II, Charles; Nyberg, Joakim; Karlsson, Mats O.; Hooker, Andrew C.

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 639-654, 2014

• DOI for Optimal clinical trial design based on a dichotomous Markov-chain mixed-effect sleep model
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Improved Utilization of ADAS-cog Assessment Data through Item Response Theory based Pharmacometric Modeling

Ueckert, Sebastian; Plan, Elodie L.; Ito, Kaori; Karlsson, Mats O. et al.

Part of Pharmaceutical research, p. 2152-2165, 2014

• DOI for Improved Utilization of ADAS-cog Assessment Data through Item Response Theory based Pharmacometric Modeling
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Modeling and Simulation Workbench for NONMEM: Tutorial on Pirana, PsN, and Xpose

Keizer, Ron J; Karlsson, M O; Hooker, Andrew C

Part of CPT, 2013

• DOI for Modeling and Simulation Workbench for NONMEM: Tutorial on Pirana, PsN, and Xpose

PopED: An extended, parallelized, nonlinear mixed effects models optimal design tool

Nyberg, Joakim; Ueckert, Sebastian; Strömberg, Eric; Hennig, Stefanie et al.

Part of Computer Methods and Programs in Biomedicine, p. 789-805, 2012

• DOI for PopED: An extended, parallelized, nonlinear mixed effects models optimal design tool

Prediction-Corrected Visual Predictive Checks for Diagnosing Nonlinear Mixed-Effects Models

Bergstrand, Martin; Hooker, Andrew C.; Wallin, Johan E.; Karlsson, Mats O.

Part of AAPS Journal, p. 143-151, 2011

• DOI for Prediction-Corrected Visual Predictive Checks for Diagnosing Nonlinear Mixed-Effects Models

Optimal Design in Population Kinetic Experiments by Set-Valued Methods

Gennemark, Peter; Danis, Alexander; Nyberg, Joakim; Hooker, Andrew C. et al.

Part of AAPS Journal, p. 495-507, 2011

• DOI for Optimal Design in Population Kinetic Experiments by Set-Valued Methods

Adaptive-Optimal Design in PET Occupancy Studies

Zamuner, S.; Di Iorio, V. L.; Nyberg, Joakim; Gunn, R. N. et al.

Part of Clinical Pharmacology and Therapeutics, p. 563-571, 2010

• DOI for Adaptive-Optimal Design in PET Occupancy Studies

Conditional weighted residuals (CWRES): a model diagnostic for the FOCE method

Hooker, Andrew C.; Staatz, Christine E; Karlsson, Mats O

Part of Pharmaceutical research, p. 2187-2197, 2007

• DOI for Conditional weighted residuals (CWRES): a model diagnostic for the FOCE method

Simultaneous population optimal design for pharmacokinetic-pharmacodynamic experiments.

Hooker, Andrew C.; Vicini, Paolo

Part of AAPS Journal, 2005

• DOI for Simultaneous population optimal design for pharmacokinetic-pharmacodynamic experiments.

Robust population pharmacokinetic experiment design.

Dodds, Michael G; Hooker, Andrew C.; Vicini, Paolo

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 33-64, 2005

• DOI for Robust population pharmacokinetic experiment design.

Optimizing Clinical Study Designs for CAR-T Cell Therapy: Development of an Efficient Sampling Strategy Through Optimal Experimental Design

Klima, Fenja; Mc Laughlin, Anna M.; Michelet, Robin; Huisinga, Wilhelm et al.

Part of CPT, 2026

• DOI for Optimizing Clinical Study Designs for CAR-T Cell Therapy: Development of an Efficient Sampling Strategy Through Optimal Experimental Design
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In Silico Clinical Trials in Drug Development: A Systematic Review

Chen, Bohua; Schneider, Lucia Chantal; Röver, Christian; Comets, Emmanuelle et al.

Part of Therapeutic Innovation and Regulatory Science, p. 423-439, 2026

• DOI for In Silico Clinical Trials in Drug Development: A Systematic Review
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Integrated Modeling of Digital-Motor and Clinician-Reported Outcomes Using Item Response Theory: Towards Powerful Trials for Rare Neurological Diseases

Hamdan, Alzahra; Traschütz, Andreas; Beichert, Lukas; Chen, Xiaomei et al.

Part of CPT, p. 1857-1868, 2025

• DOI for Integrated Modeling of Digital-Motor and Clinician-Reported Outcomes Using Item Response Theory: Towards Powerful Trials for Rare Neurological Diseases
• Download full text (pdf) of Integrated Modeling of Digital-Motor and Clinician-Reported Outcomes Using Item Response Theory: Towards Powerful Trials for Rare Neurological Diseases

A Pharmacometrics-Informed Trial Simulation Framework for Optimizing Study Designs for Disease-Modifying Treatments in Rare Neurological Disorders

Ryeznik, Yevgen; Hilgers, Ralf-Dieter; Heussen, Nicole; Comets, Emmanuelle et al.

Part of CPT, p. 1705-1714, 2025

• DOI for A Pharmacometrics-Informed Trial Simulation Framework for Optimizing Study Designs for Disease-Modifying Treatments in Rare Neurological Disorders
• Download full text (pdf) of A Pharmacometrics-Informed Trial Simulation Framework for Optimizing Study Designs for Disease-Modifying Treatments in Rare Neurological Disorders

Leveraging Model Master Files for Long-Acting Injectables

Gong, Yuqing; Hopefl, Robert; Li, Tonglei; Hooker, Andrew et al.

Part of Pharmaceutical research, p. 747-752, 2025

• DOI for Leveraging Model Master Files for Long-Acting Injectables
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Optimizing Clinical Study Designs for CAR-T Cell Therapy: Development of an Efficient Sampling Strategy Through Optimal Experimental Design

Klima, Fenja; Mc Laughlin, Anna M.; Michelet, Robin; Huisinga, Wilhelm et al.

Part of CPT, 2026

• DOI for Optimizing Clinical Study Designs for CAR-T Cell Therapy: Development of an Efficient Sampling Strategy Through Optimal Experimental Design
• Download full text (pdf) of Optimizing Clinical Study Designs for CAR-T Cell Therapy: Development of an Efficient Sampling Strategy Through Optimal Experimental Design

Integrated Modeling of Digital-Motor and Clinician-Reported Outcomes Using Item Response Theory: Towards Powerful Trials for Rare Neurological Diseases

Hamdan, Alzahra; Traschütz, Andreas; Beichert, Lukas; Chen, Xiaomei et al.

Part of CPT, p. 1857-1868, 2025

• DOI for Integrated Modeling of Digital-Motor and Clinician-Reported Outcomes Using Item Response Theory: Towards Powerful Trials for Rare Neurological Diseases
• Download full text (pdf) of Integrated Modeling of Digital-Motor and Clinician-Reported Outcomes Using Item Response Theory: Towards Powerful Trials for Rare Neurological Diseases

A Pharmacometrics-Informed Trial Simulation Framework for Optimizing Study Designs for Disease-Modifying Treatments in Rare Neurological Disorders

Ryeznik, Yevgen; Hilgers, Ralf-Dieter; Heussen, Nicole; Comets, Emmanuelle et al.

Part of CPT, p. 1705-1714, 2025

• DOI for A Pharmacometrics-Informed Trial Simulation Framework for Optimizing Study Designs for Disease-Modifying Treatments in Rare Neurological Disorders
• Download full text (pdf) of A Pharmacometrics-Informed Trial Simulation Framework for Optimizing Study Designs for Disease-Modifying Treatments in Rare Neurological Disorders

Leveraging Model Master Files for Long-Acting Injectables

Gong, Yuqing; Hopefl, Robert; Li, Tonglei; Hooker, Andrew et al.

Part of Pharmaceutical research, p. 747-752, 2025

• DOI for Leveraging Model Master Files for Long-Acting Injectables
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Comparing randomized trial designs to estimate treatment effect in rare diseases with longitudinal models: a simulation study showcased by Autosomal Recessive Cerebellar Ataxias using the SARA score

Hendrickx, Niels; Mentré, France; Hamdan, Alzahra; Karlsson, Mats O. et al.

Part of BMC Medical Research Methodology, 2025

• DOI for Comparing randomized trial designs to estimate treatment effect in rare diseases with longitudinal models: a simulation study showcased by Autosomal Recessive Cerebellar Ataxias using the SARA score
• Download full text (pdf) of Comparing randomized trial designs to estimate treatment effect in rare diseases with longitudinal models: a simulation study showcased by Autosomal Recessive Cerebellar Ataxias using the SARA score

Reflection on clinical and methodological issues in rare disease clinical trials.

Verbeeck, Johan; Geroldinger, Martin; Nyberg, Joakim; Thiel, Konstantin E. et al.

Part of Orphanet Journal of Rare Diseases, 2025

• DOI for Reflection on clinical and methodological issues in rare disease clinical trials.
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A Comparison of Statistical Methods for Time-To-Event Analyses in Randomized Controlled Trials Under Non-Proportional Hazards

Klinglmüller, Florian; Fellinger, Tobias; König, Franz; Friede, Tim et al.

Part of Statistics in Medicine, 2025

• DOI for A Comparison of Statistical Methods for Time-To-Event Analyses in Randomized Controlled Trials Under Non-Proportional Hazards
• Download full text (pdf) of A Comparison of Statistical Methods for Time-To-Event Analyses in Randomized Controlled Trials Under Non-Proportional Hazards

Optimizing the design of a pharmacokinetic trial to evaluate the dosing scheme of a novel tuberculosis drug in children living with or without HIV

Montepiedra, Grace; Svensson, Elin; Wong, Weng Kee; Hooker, Andrew

Part of CPT, p. 270-280, 2024

• DOI for Optimizing the design of a pharmacokinetic trial to evaluate the dosing scheme of a novel tuberculosis drug in children living with or without HIV
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Evaluation of model-integrated evidence approaches for pharmacokinetic bioequivalence studies using model averaging methods

Bjugård Nyberg, Henrik; Chen, Xiaomei; Donnelly, Mark; Fang, Lanyan et al.

Part of CPT, p. 1748-1761, 2024

• DOI for Evaluation of model-integrated evidence approaches for pharmacokinetic bioequivalence studies using model averaging methods
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A fully automatic tool for development of population pharmacokinetic models

Chen, Xiaomei; Nordgren, Rikard; Belin, Stella; Hamdan, Alzahra et al.

Part of CPT, p. 1784-1797, 2024

• DOI for A fully automatic tool for development of population pharmacokinetic models
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Longitudinal Analysis of Natural History Progression of Rare and Ultra‐Rare Cerebellar Ataxias Using Item Response Theory

Hamdan, Alzahra; Hendrickx, Niels; Hooker, Andrew C.; Chen, Xiaomei et al.

Part of Clinical Pharmacology and Therapeutics, p. 1593-1605, 2024

• DOI for Longitudinal Analysis of Natural History Progression of Rare and Ultra‐Rare Cerebellar Ataxias Using Item Response Theory
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Development and comparison of model-integrated evidence approaches for bioequivalence studies with pharmacokinetic end points

Chen, Xiaomei; Bjugård Nyberg, Henrik; Donnelly, Mark; Zhao, Liang et al.

Part of CPT, p. 1734-1747, 2024

• DOI for Development and comparison of model-integrated evidence approaches for bioequivalence studies with pharmacokinetic end points
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Item performance of the scale for the assessment and rating of ataxia in rare and ultra-rare genetic ataxias

Hamdan, Alzahra; Hooker, Andrew C.; Chen, Xiaomei; Traschütz, Andreas et al.

Part of CPT, p. 1327-1340, 2024

• DOI for Item performance of the scale for the assessment and rating of ataxia in rare and ultra-rare genetic ataxias
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Optimizing designs in clinical trials with an application in treatment of Epidermolysis bullosa simplex, a rare genetic skin disease

Nyberg, Joakim; Hooker, Andrew; Zimmermann, Georg; Verbeeck, Johan et al.

Part of Computational Statistics & Data Analysis, 2024

• DOI for Optimizing designs in clinical trials with an application in treatment of Epidermolysis bullosa simplex, a rare genetic skin disease
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The Role of Model Master Files for Sharing, Acceptance, and Communication with FDA

Fang, Lanyan; Gong, Yuqing; Hooker, Andrew; Lukacova, Viera et al.

Part of AAPS Journal, 2024

• DOI for The Role of Model Master Files for Sharing, Acceptance, and Communication with FDA

Generation and application of avatars in pharmacometric modelling

Chasseloup, Estelle; Hooker, Andrew; Karlsson, Mats

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 411-423, 2023

• DOI for Generation and application of avatars in pharmacometric modelling
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How to Analyze Continuous and Discrete Repeated Measures in Small-Sample Cross-Over Trials?

Verbeeck, Johan; Geroldinger, Martin; Thiel, Konstantin; Hooker, Andrew Craig et al.

Part of Biometrics, p. 3998-4011, 2023

• DOI for How to Analyze Continuous and Discrete Repeated Measures in Small-Sample Cross-Over Trials?

Statistical recommendations for count, binary, and ordinal data in rare disease cross-over trials

Geroldinger, Martin; Verbeeck, Johan; Hooker, Andrew C.; Thiel, Konstantin E. et al.

Part of Orphanet Journal of Rare Diseases, 2023

• DOI for Statistical recommendations for count, binary, and ordinal data in rare disease cross-over trials
• Download full text (pdf) of Statistical recommendations for count, binary, and ordinal data in rare disease cross-over trials

Bounded Integer Modeling of Symptom Scales Specific to Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia

Lyauk, Yassine Kamal; Jonker, Daniel M.; Hooker, Andrew; Lund, Trine Meldgaard et al.

Part of AAPS Journal, 2021

• DOI for Bounded Integer Modeling of Symptom Scales Specific to Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia
• Download full text (pdf) of Bounded Integer Modeling of Symptom Scales Specific to Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia

Pharmacometrics meets statistics-A synergy for modern drug development

Ryeznik, Yevgen; Sverdlov, Oleksandr; Svensson, Elin; Montepiedra, Grace et al.

Part of CPT, p. 1134-1149, 2021

• DOI for Pharmacometrics meets statistics-A synergy for modern drug development
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Tutorial for $DESIGN in NONMEM: Clinical trial evaluation and optimization

Bauer, Robert J.; Hooker, Andrew; Mentre, France

Part of CPT, p. 1452-1465, 2021

• DOI for Tutorial for $DESIGN in NONMEM: Clinical trial evaluation and optimization
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Public Workshop Summary Report on Fiscal Year 2021 Generic Drug Regulatory Science Initiatives: Data Analysis and Model-Based Bioequivalence.

Lee, Jieon; Gong, Yuqing; Bhoopathy, Sid; DiLiberti, Charles E et al.

Part of Clinical Pharmacology and Therapeutics, p. 1190-1195, 2021

• DOI for Public Workshop Summary Report on Fiscal Year 2021 Generic Drug Regulatory Science Initiatives: Data Analysis and Model-Based Bioequivalence.
• Download full text (pdf) of Public Workshop Summary Report on Fiscal Year 2021 Generic Drug Regulatory Science Initiatives: Data Analysis and Model-Based Bioequivalence.

Model-Informed Drug Development for Long-Acting Injectable Products: Summary of American College of Clinical Pharmacology Symposium

Sharan, Satish; Fang, Lanyan; Lukacova, Viera; Chen, Xiaomei et al.

Part of Clinical Pharmacology in Drug Development, p. 220-228, 2021

• DOI for Model-Informed Drug Development for Long-Acting Injectable Products: Summary of American College of Clinical Pharmacology Symposium

Item Response Theory Modeling of the International Prostate Symptom Score in Patients with Lower Urinary Tract Symptoms Associated with Benign Prostatic Hyperplasia

Lyauk, Yassine Kamal; Jonker, Daniel M.; Lund, Trine Meldgaard; Hooker, Andrew et al.

Part of AAPS Journal, 2020

• DOI for Item Response Theory Modeling of the International Prostate Symptom Score in Patients with Lower Urinary Tract Symptoms Associated with Benign Prostatic Hyperplasia
• Download full text (pdf) of Item Response Theory Modeling of the International Prostate Symptom Score in Patients with Lower Urinary Tract Symptoms Associated with Benign Prostatic Hyperplasia

Population Pharmacokinetics and Dosing of Ethionamide in Children with Tuberculosis

Bjugård Nyberg, Henrik; Draper, Heather R.; Garcia-Prats, Anthony J.; Thee, Stephanie et al.

Part of Antimicrobial Agents and Chemotherapy, 2020

• DOI for Population Pharmacokinetics and Dosing of Ethionamide in Children with Tuberculosis

Saddle-Reset for Robust Parameter Estimation and Identifiability Analysis of Nonlinear Mixed Effects Models

Bjugård Nyberg, Henrik; Hooker, Andrew C.; Bauer, Robert J; Aoki, Yasunori

Part of AAPS Journal, 2020

• DOI for Saddle-Reset for Robust Parameter Estimation and Identifiability Analysis of Nonlinear Mixed Effects Models
• Download full text (pdf) of Saddle-Reset for Robust Parameter Estimation and Identifiability Analysis of Nonlinear Mixed Effects Models

Optimizing Dose-Finding Studies for Drug Combinations Based on Exposure-Response Models

Papathanasiou, Theodoros; Strathe, Anders; Overgaard, Rune Viig; Lund, Trine Meldgaard et al.

Part of AAPS Journal, 2019

• DOI for Optimizing Dose-Finding Studies for Drug Combinations Based on Exposure-Response Models

Feasibility of Exposure-Response Analyses for Clinical Dose-Ranging Studies of Drug Combinations

Papathanasiou, Theodoros; Strathe, Anders; Hooker, Andrew C.; Lund, Trine Meldgaard et al.

Part of AAPS Journal, 2018

• DOI for Feasibility of Exposure-Response Analyses for Clinical Dose-Ranging Studies of Drug Combinations

Adaptive Optimal Designs for Dose-Finding Studies with Time-to-Event Outcomes

Ryeznik, Yevgen; Sverdlov, Oleksandr; Hooker, Andrew C

Part of AAPS Journal, 2018

• DOI for Adaptive Optimal Designs for Dose-Finding Studies with Time-to-Event Outcomes
• Download full text (pdf) of Adaptive Optimal Designs for Dose-Finding Studies with Time-to-Event Outcomes

A Population Pharmacokinetic-Pharmacodynamic Model of Pegfilgrastim

Brekkan, Ari; Lopez-Lazaro, Luis; Yngman, Gunnar; Plan, Elodie L. et al.

Part of AAPS Journal, 2018

• DOI for A Population Pharmacokinetic-Pharmacodynamic Model of Pegfilgrastim
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Implementing Optimal Designs for Dose-Response Studies Through Adaptive Randomization for a Small Population Group

Ryeznik, Yevgen; Sverdlov, Oleksandr; Hooker, Andrew

Part of AAPS Journal, 2018

• DOI for Implementing Optimal Designs for Dose-Response Studies Through Adaptive Randomization for a Small Population Group
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Model-Based Adaptive Optimal Design (MBAOD) Improves Combination Dose Finding Designs: an Example in Oncology

Pierrillas, Philippe B.; Fouliard, Sylvain; Chenel, Marylore; Hooker, Andrew et al.

Part of AAPS Journal, 2018

• DOI for Model-Based Adaptive Optimal Design (MBAOD) Improves Combination Dose Finding Designs: an Example in Oncology
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The Standard Output: A Tool-Agnostic Modeling Storage Format

Terranova, Nadia; Smith, Mike K.; Nordgren, Rikard; Comets, Emmanuelle et al.

Part of CPT, p. 543-546, 2018

• DOI for The Standard Output: A Tool-Agnostic Modeling Storage Format
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Reduced and optimized trial designs for drugs described by a target mediated drug disposition model

Brekkan, Ari; Jönsson, Siv; Karlsson, Mats O; Hooker, Andrew

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 637-647, 2018

• DOI for Reduced and optimized trial designs for drugs described by a target mediated drug disposition model
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Model-Informed Drug Development and Review for Generic Products: Summary Of FDA Public Workshop

Fang, Lanyan; Kim, Myong-Jin; Li, Zhichuan; Wang, Yaning et al.

Part of Clinical Pharmacology and Therapeutics, p. 27-30, 2018

• DOI for Model-Informed Drug Development and Review for Generic Products: Summary Of FDA Public Workshop

Model Description Language (MDL): A Standard for Modeling and Simulation

Smith, Mike K.; Moodie, Stuart L.; Bizzotto, Roberto; Blaudez, Eric et al.

Part of CPT, p. 647-650, 2017

• DOI for Model Description Language (MDL): A Standard for Modeling and Simulation

Advanced Methods for Dose and Regimen Finding During Drug Development: Summary of the EMA/EFPIA Workshop on Dose Finding (London 4-5 December 2014)

Musuamba, F. T.; Manolis, E.; Holford, N.; Cheung, S. Y. A. et al.

Part of CPT, p. 418-429, 2017

• DOI for Advanced Methods for Dose and Regimen Finding During Drug Development: Summary of the EMA/EFPIA Workshop on Dose Finding (London 4-5 December 2014)

Model Evaluation of Continuous Data Pharmacometric Models: Metrics and Graphics

Nguyen, T. H. T.; Mouksassi, M-S; Holford, N.; Al-Huniti, N. et al.

Part of CPT, p. 87-109, 2017

• DOI for Model Evaluation of Continuous Data Pharmacometric Models: Metrics and Graphics
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Assessing robustness of designs for random effects parameters for nonlinear mixed-effects models

Duffull, Stephen B.; Hooker, Andrew

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 611-616, 2017

• DOI for Assessing robustness of designs for random effects parameters for nonlinear mixed-effects models

Model selection and averaging of nonlinear mixed-effect models for robust phase III dose selection

Aoki, Yasunori; Roshammar, Daniel; Hamren, Bengt; Hooker, Andrew

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 581-597, 2017

• DOI for Model selection and averaging of nonlinear mixed-effect models for robust phase III dose selection
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Maturation of Oxycodone Pharmacokinetics in Neonates and Infants: a Population Pharmacokinetic Model of Three Clinical Trials

Valitalo, Pyry; Kokki, Merja; Ranta, Veli-Pekka; Olkkola, Klaus T. et al.

Part of Pharmaceutical research, p. 1125-1133, 2017

• DOI for Maturation of Oxycodone Pharmacokinetics in Neonates and Infants: a Population Pharmacokinetic Model of Three Clinical Trials

The effect of using a robust optimality criterion in model based adaptive optimization.

Strömberg, Eric; Hooker, Andrew

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 317-324, 2017

• DOI for The effect of using a robust optimality criterion in model based adaptive optimization.
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Preconditioning of Nonlinear Mixed Effects Models for Stabilisation of Variance-Covariance Matrix Computations

Aoki, Yasunori; Nordgren, Rikard; Hooker, Andrew C.

Part of AAPS Journal, p. 505-518, 2016

• DOI for Preconditioning of Nonlinear Mixed Effects Models for Stabilisation of Variance-Covariance Matrix Computations

The effect of Fisher information matrix approximation methods in population optimal design calculations

Strömberg, Eric; Nyberg, Joakim; Hooker, Andrew

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 609-619, 2016

• DOI for The effect of Fisher information matrix approximation methods in population optimal design calculations
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PopED lite: an optimal design software for preclinical pharmacokinetic and pharmacodynamic studies

Aoki, Yasunori; Monika, Sundqvist; Hooker, Andrew C.; Gennemark, Peter

Part of Computer Methods and Programs in Biomedicine, p. 126-143, 2016

• DOI for PopED lite: an optimal design software for preclinical pharmacokinetic and pharmacodynamic studies

A diagnostic tool for population models using non-compartmental analysis: The ncappc package for R

Acharya, Chayan; Hooker, Andrew C.; Turkyilmaz, Gulbeyaz Yildiz; Jönsson, Siv et al.

Part of Computer Methods and Programs in Biomedicine, p. 83-93, 2016

• DOI for A diagnostic tool for population models using non-compartmental analysis: The ncappc package for R
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Accelerating Monte Carlo power studies through parametric power estimation

Ueckert, Sebastian; Karlsson, Mats O.; Hooker, Andrew C

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 223-234, 2016

• DOI for Accelerating Monte Carlo power studies through parametric power estimation
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Pharmacometrics Markup Language (PharmML): Opening New Perspectives for Model Exchange in Drug Development

Swat, M. J.; Moodie, S.; Wimalaratne, S. M.; Kristensen, N. R. et al.

Part of CPT, p. 316-319, 2015

• DOI for Pharmacometrics Markup Language (PharmML): Opening New Perspectives for Model Exchange in Drug Development
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Estimation of drug receptor occupancy when non-displaceable binding differs between brain regions: extending the simplified reference tissue model

Kågedal, Matts; Varnäs, Katarina; Hooker, Andrew C; Karlsson, Mats O

Part of British Journal of Clinical Pharmacology, p. 116-127, 2015

• DOI for Estimation of drug receptor occupancy when non-displaceable binding differs between brain regions: extending the simplified reference tissue model

Improved precision of exposure-response relationships by optimal dose-selection. Examples from studies of receptor occupancy using PET and dose finding for neuropathic pain treatment

Kågedal, Matts; Karlsson, Mats; Hooker, Andrew C

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 211-224, 2015

• DOI for Improved precision of exposure-response relationships by optimal dose-selection. Examples from studies of receptor occupancy using PET and dose finding for neuropathic pain treatment

Methods and software tools for design evaluation for population pharmacokinetics-pharmacodynamics studies

Nyberg, Joakim; Bazzoli, Caroline; Ogungbenro, Kay; Aliev, Alexander et al.

Part of British Journal of Clinical Pharmacology, p. 6-17, 2015

• DOI for Methods and software tools for design evaluation for population pharmacokinetics-pharmacodynamics studies

Simultaneous pharmacokinetic modeling of alkylresorcinols and their main metabolites indicates dual absorption mechanisms and enterohepatic elimination in humans

Marklund, Matti; Strömberg, Eric A; Lærke, Helle N; Knudsen, Knud E Bach et al.

Part of Journal of Nutrition, p. 1674-1680, 2014

• DOI for Simultaneous pharmacokinetic modeling of alkylresorcinols and their main metabolites indicates dual absorption mechanisms and enterohepatic elimination in humans

Optimal clinical trial design based on a dichotomous Markov-chain mixed-effect sleep model

Ernest II, Charles; Nyberg, Joakim; Karlsson, Mats O.; Hooker, Andrew C.

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 639-654, 2014

• DOI for Optimal clinical trial design based on a dichotomous Markov-chain mixed-effect sleep model
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Improved Utilization of ADAS-cog Assessment Data through Item Response Theory based Pharmacometric Modeling

Ueckert, Sebastian; Plan, Elodie L.; Ito, Kaori; Karlsson, Mats O. et al.

Part of Pharmaceutical research, p. 2152-2165, 2014

• DOI for Improved Utilization of ADAS-cog Assessment Data through Item Response Theory based Pharmacometric Modeling
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Evaluation of Bias, Precision, Robustness and Runtime for Estimation Methods in NONMEM 7

Johansson, Åsa M.; Ueckert, Sebastian; Plan, Elodie L.; Hooker, Andrew C. et al.

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 223-238, 2014

• DOI for Evaluation of Bias, Precision, Robustness and Runtime for Estimation Methods in NONMEM 7

Current Use and Developments Needed for Optimal Design in Pharmacometrics: A Study Performed Among DDMoRe's European Federation of Pharmaceutical Industries and Associations Members

Mentré, F; Chenel, M; Comets, E; Grevel, J et al.

Part of CPT, 2013

• DOI for Current Use and Developments Needed for Optimal Design in Pharmacometrics: A Study Performed Among DDMoRe's European Federation of Pharmaceutical Industries and Associations Members

Modeling and Simulation Workbench for NONMEM: Tutorial on Pirana, PsN, and Xpose

Keizer, Ron J; Karlsson, M O; Hooker, Andrew C

Part of CPT, 2013

• DOI for Modeling and Simulation Workbench for NONMEM: Tutorial on Pirana, PsN, and Xpose

Optimizing disease progression study designs for drug effect discrimination

Ueckert, Sebastian; Hennig, Stefanie; Nyberg, Joakim; Karlsson, Mats O. et al.

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 587-596, 2013

• DOI for Optimizing disease progression study designs for drug effect discrimination

A positron emission tomography study in healthy volunteers to estimate mGluR5 receptor occupancy of AZD2066-Estimating occupancy in the absence of a reference region

Kågedal, Matts; Cselenyi, Zsolt; Nyberg, Svante; Raboisson, Patrick et al.

Part of NeuroImage, p. 160-169, 2013

• DOI for A positron emission tomography study in healthy volunteers to estimate mGluR5 receptor occupancy of AZD2066-Estimating occupancy in the absence of a reference region

Simultaneous optimal experimental design for in vitro binding parameter estimation

Ernest II, Charles Steven; Karlsson, Mats O.; Hooker, Andrew C.

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 573-585, 2013

• DOI for Simultaneous optimal experimental design for in vitro binding parameter estimation

Chain length of dietary alkylresorcinols affects their in vivo elimination kinetics in rats

Marklund, Matti; Strömberg, Eric A; Hooker, Andrew C; Hammarlund-Udenaes, Margareta et al.

Part of Journal of Nutrition, p. 1573-1578, 2013

• DOI for Chain length of dietary alkylresorcinols affects their in vivo elimination kinetics in rats

PopED: An extended, parallelized, nonlinear mixed effects models optimal design tool

Nyberg, Joakim; Ueckert, Sebastian; Strömberg, Eric; Hennig, Stefanie et al.

Part of Computer Methods and Programs in Biomedicine, p. 789-805, 2012

• DOI for PopED: An extended, parallelized, nonlinear mixed effects models optimal design tool

Ethically Attractive Dose-Finding Designs for Drugs With a Narrow Therapeutic Index

Lledó-García, Rocío; Hennig, Stefanie; Nyberg, Joakim; Hooker, Andrew C et al.

Part of Journal of clinical pharmacology, p. 29-38, 2012

• DOI for Ethically Attractive Dose-Finding Designs for Drugs With a Narrow Therapeutic Index

Application of the Optimal Design Approach to Improve a Pretransplant Drug Dose Finding Design for Ciclosporin

Hennig, Stefanie; Nyberg, Joakim; Fanta, Samuel; Backman, Janne T. et al.

Part of Journal of clinical pharmacology, p. 347-360, 2012

• DOI for Application of the Optimal Design Approach to Improve a Pretransplant Drug Dose Finding Design for Ciclosporin

Serial correlation in optimal design for nonlinear mixed effects models

Nyberg, Joakim; Höglund, Richard; Bergstrand, Martin; Karlsson, Mats O. et al.

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 239-249, 2012

• DOI for Serial correlation in optimal design for nonlinear mixed effects models

Plasma and Cerebrospinal Fluid Pharmacokinetics of Naproxen in Children

Välitalo, Pyry; Kumpulainen, Elina; Manner, Minna; Kokki, Merja et al.

Part of Journal of clinical pharmacology, p. 1516-1526, 2012

• DOI for Plasma and Cerebrospinal Fluid Pharmacokinetics of Naproxen in Children

Non-linear mixed effects modelling of positron emission tomography data for simultaneous estimation of radioligand kinetics and occupancy in healthy volunteers

Kågedal, Matts; Cselényi, Zsolt; Nyberg, Svante; Jönsson, Siv et al.

Part of NeuroImage, p. 849-856, 2012

• DOI for Non-linear mixed effects modelling of positron emission tomography data for simultaneous estimation of radioligand kinetics and occupancy in healthy volunteers

Joint Modeling of Efficacy, Dropout, and Tolerability in Flexible-Dose Trials: A Case Study in Depression

Russu, A.; Marostica, E.; De Nicolao, G.; Hooker, Andrew C. et al.

Part of Clinical Pharmacology and Therapeutics, p. 863-871, 2012

• DOI for Joint Modeling of Efficacy, Dropout, and Tolerability in Flexible-Dose Trials: A Case Study in Depression

Prediction-Corrected Visual Predictive Checks for Diagnosing Nonlinear Mixed-Effects Models

Bergstrand, Martin; Hooker, Andrew C.; Wallin, Johan E.; Karlsson, Mats O.

Part of AAPS Journal, p. 143-151, 2011

• DOI for Prediction-Corrected Visual Predictive Checks for Diagnosing Nonlinear Mixed-Effects Models

Optimal Design in Population Kinetic Experiments by Set-Valued Methods

Gennemark, Peter; Danis, Alexander; Nyberg, Joakim; Hooker, Andrew C. et al.

Part of AAPS Journal, p. 495-507, 2011

• DOI for Optimal Design in Population Kinetic Experiments by Set-Valued Methods

Multinomial Logistic Functions in Markov Chain Models of Sleep Architecture: Internal and External Validation and Covariate Analysis

Bizzotto, Roberto; Zamuner, Stefano; Mezzalana, Enrica; De Nicolao, Giuseppe et al.

Part of AAPS Journal, p. 445-463, 2011

• DOI for Multinomial Logistic Functions in Markov Chain Models of Sleep Architecture: Internal and External Validation and Covariate Analysis

A Fast Method for Testing Covariates in Population PK/PD Models

Khandelwal, Akash; Harling, Kajsa; Jonsson, Niclas E.; Hooker, Andrew C. et al.

Part of AAPS Journal, p. 464-472, 2011

• DOI for A Fast Method for Testing Covariates in Population PK/PD Models

Optimal experimental design for assessment of enzyme kinetics in a drug discovery screening environment

Sjögren, Erik; Nyberg, Joakim; Magnusson, Mats O.; Lennernäs, Hans et al.

Part of Drug Metabolism And Disposition, p. 858-863, 2011

• DOI for Optimal experimental design for assessment of enzyme kinetics in a drug discovery screening environment

Adaptive-Optimal Design in PET Occupancy Studies

Zamuner, S.; Di Iorio, V. L.; Nyberg, Joakim; Gunn, R. N. et al.

Part of Clinical Pharmacology and Therapeutics, p. 563-571, 2010

• DOI for Adaptive-Optimal Design in PET Occupancy Studies

Plasma and cerebrospinal fluid pharmacokinetics of flurbiprofen in children

Kumpulainen, Elina; Valitalo, Pyry; Kokki, Merja; Lehtonen, Marko et al.

Part of British Journal of Clinical Pharmacology, p. 557-566, 2010

• DOI for Plasma and cerebrospinal fluid pharmacokinetics of flurbiprofen in children

Methodological Comparison of In Vitro Binding Parameter Estimation: Sequential vs. Simultaneous Non-linear Regression

Ernest, C. Steven; Hooker, Andrew C.; Karlsson, Mats O.

Part of Pharmaceutical research, p. 866-877, 2010

• DOI for Methodological Comparison of In Vitro Binding Parameter Estimation: Sequential vs. Simultaneous Non-linear Regression

Modeling subpopulations with the $MIXTURE subroutine in NONMEM: finding the individual probability of belonging to a subpopulation for the use in model analysis and improved decision making

Karlsson, Kristin C.; Savić, Radojka M.; Hooker, Andrew C.; Karlsson, Mats O

Part of AAPS Journal, p. 148-154, 2009

• DOI for Modeling subpopulations with the $MIXTURE subroutine in NONMEM: finding the individual probability of belonging to a subpopulation for the use in model analysis and improved decision making

Trial treatment length optimization with an emphasis on disease progression studies

Hennig, Stefanie; Nyberg, Joakim; Hooker, Andrew C; Karlsson, Mats O

Part of Journal of clinical pharmacology, p. 323-335, 2009

• DOI for Trial treatment length optimization with an emphasis on disease progression studies

Simultaneous optimal experimental design on dose and sample times

Nyberg, Joakim; Karlsson, Mats O.; Hooker, Andrew C.

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 125-145, 2009

• DOI for Simultaneous optimal experimental design on dose and sample times

Optimization of the intravenous glucose tolerance test in T2DM patients using optimal experimental design

Silber, Hanna E.; Nyberg, Joakim; Hooker, Andrew C.; Karlsson, Mats O.

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 281-295, 2009

• DOI for Optimization of the intravenous glucose tolerance test in T2DM patients using optimal experimental design
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Population pharmacokinetic model for docetaxel in patients with varying degrees of liver function: incorporating cytochrome P4503A activity measurements

Hooker, Andrew C; Ten Tije, A J; Carducci, M A; Weber, J et al.

Part of Clinical Pharmacology and Therapeutics, p. 111-118, 2008

• DOI for Population pharmacokinetic model for docetaxel in patients with varying degrees of liver function: incorporating cytochrome P4503A activity measurements

Non-Bayesian Knowledge Propagation using Model Model-Based Analysis of Data from Multiple Clinical Studies

Ribbing, Jakob; Hooker, Andrew C; Jonsson, E Niclas

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 117-137, 2008

• DOI for Non-Bayesian Knowledge Propagation using Model Model-Based Analysis of Data from Multiple Clinical Studies

Pharmacokinetics of P-glycoprotein inhibition in the rat blood-brain barrier

Syvänen, Stina; Hooker, Andrew; Rahman, Obaidur; Wilking, Helena et al.

Part of Journal of Pharmaceutical Sciences, p. 5386-5400, 2008

• DOI for Pharmacokinetics of P-glycoprotein inhibition in the rat blood-brain barrier

Conditional weighted residuals (CWRES): a model diagnostic for the FOCE method

Hooker, Andrew C.; Staatz, Christine E; Karlsson, Mats O

Part of Pharmaceutical research, p. 2187-2197, 2007

• DOI for Conditional weighted residuals (CWRES): a model diagnostic for the FOCE method

Automated identification of axonal growth cones in time-lapse image sequences.

Keenan, Thomas M; Hooker, Andrew C.; Spilker, Mary E; Li, Nianzhen et al.

Part of Journal of Neuroscience Methods, p. 232-8, 2006

• DOI for Automated identification of axonal growth cones in time-lapse image sequences.

Simultaneous population optimal design for pharmacokinetic-pharmacodynamic experiments.

Hooker, Andrew C.; Vicini, Paolo

Part of AAPS Journal, 2005

• DOI for Simultaneous population optimal design for pharmacokinetic-pharmacodynamic experiments.

Robust population pharmacokinetic experiment design.

Dodds, Michael G; Hooker, Andrew C.; Vicini, Paolo

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 33-64, 2005

• DOI for Robust population pharmacokinetic experiment design.

POPED, a software for optimal experiment design in population kinetics.

Foracchia, Marco; Hooker, Andrew C.; Vicini, Paolo; Ruggeri, Alfredo

Part of Computer Methods and Programs in Biomedicine, p. 29-46, 2004

• DOI for POPED, a software for optimal experiment design in population kinetics.

An evaluation of population D-optimal designs via pharmacokinetic simulations.

Hooker, Andrew C; Foracchia, Marco; Dodds, Michael G; Vicini, Paolo

Part of Annals of Biomedical Engineering, p. 98-111, 2003

Quantitative magnetic resonance imaging analysis of neovasculature volume in carotid atherosclerotic plaque.

Kerwin, William; Hooker, Andrew C.; Spilker, Mary; Vicini, Paolo et al.

Part of Circulation, p. 851-6, 2003

Classical examination of the Stark effect in hydrogen

Hooker, Andrew C.; Greene, Chris H.; Clark, William

Part of Physical Review A. Atomic, Molecular, and Optical Physics, p. 4609-4612, 1997

• DOI for Classical examination of the Stark effect in hydrogen

In Silico Clinical Trials in Drug Development: A Systematic Review

Chen, Bohua; Schneider, Lucia Chantal; Röver, Christian; Comets, Emmanuelle et al.

Part of Therapeutic Innovation and Regulatory Science, p. 423-439, 2026

• DOI for In Silico Clinical Trials in Drug Development: A Systematic Review
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Methods for non-proportional hazards in clinical trials: A systematic review

Bardo, Maximilian; Huber, Cynthia; Benda, Norbert; Brugger, Jonas et al.

Part of Statistical Methods in Medical Research, p. 1069-1092, 2024

• DOI for Methods for non-proportional hazards in clinical trials: A systematic review
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Establishing the suitability of model-integrated evidence to demonstrate bioequivalence for long-acting injectable and implantable drug products: Summary of workshop

Gong, Yuqing; Zhang, Peijue; Yoon, Miyoung; Zhu, Hao et al.

Part of CPT, p. 624-630, 2023

• DOI for Establishing the suitability of model-integrated evidence to demonstrate bioequivalence for long-acting injectable and implantable drug products: Summary of workshop
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Metaheuristics for pharmacometrics

Kim, Seongho; Hooker, Andrew; Shi, Yu; Kim, Grace Hyun J. et al.

Part of CPT, p. 1297-1309, 2021

• DOI for Metaheuristics for pharmacometrics
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Population pharmacometrics in support of analgesics studies

Valitalo, P.; Ranta, V. -P; Hooker, Andrew C.; Kokki, M. et al.

Part of Acta Anaesthesiologica Scandinavica, p. 143-156, 2014

• DOI for Population pharmacometrics in support of analgesics studies