Alfhild Grönblad

The effects of insulin-regulated aminopeptidase inhibition with HA08 on recognition memory acquisition and spatial working memory under reversed circadian conditions in male rats

Stam, Frida; Lind, Sara Florén; Zelleroth, Sofia; Badrd'din, Sally et al.

Part of IBRO Neuroscience Reports, p. 854-861, 2025

• DOI for The effects of insulin-regulated aminopeptidase inhibition with HA08 on recognition memory acquisition and spatial working memory under reversed circadian conditions in male rats
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Insulin-regulated aminopeptidase inhibitor C9 restores cellular activity in methadone-damaged primary cell cultures

Stam, Frida; Lind, Sara Florén; Nylander, Erik; Olaniran Håkansson, Esther et al.

Part of Neuroscience Letters, 2025

• DOI for Insulin-regulated aminopeptidase inhibitor C9 restores cellular activity in methadone-damaged primary cell cultures
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Cafeteria diet and caloric restriction affect metabolic but not behavioral characteristics in male Wistar rats

Kagios, Christakis; Hetty, Susanne; Grönbladh, Alfhild; Pereira, Maria J. et al.

Part of Physiology and Behavior, 2025

• DOI for Cafeteria diet and caloric restriction affect metabolic but not behavioral characteristics in male Wistar rats
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N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands

Wannberg, Johan; Gising, Johan; Henriksson, Martin; Vo, Duc Duy et al.

Part of European Journal of Medicinal Chemistry, 2024

• DOI for N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
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Inhibition of IRAP Enhances the Expression of Pro-Cognitive Markers Drebrin and MAP2 in Rat Primary Neuronal Cells

Stam, Frida; Lind, Sara Florén; Nylander, Erik; Olaniran, Esther et al.

Part of International Journal of Molecular Sciences, 2024

• DOI for Inhibition of IRAP Enhances the Expression of Pro-Cognitive Markers Drebrin and MAP2 in Rat Primary Neuronal Cells
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The effects of insulin-regulated aminopeptidase inhibition with HA08 on recognition memory acquisition and spatial working memory under reversed circadian conditions in male rats

Stam, Frida; Lind, Sara Florén; Zelleroth, Sofia; Badrd'din, Sally et al.

Part of IBRO Neuroscience Reports, p. 854-861, 2025

• DOI for The effects of insulin-regulated aminopeptidase inhibition with HA08 on recognition memory acquisition and spatial working memory under reversed circadian conditions in male rats
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Insulin-regulated aminopeptidase inhibitor C9 restores cellular activity in methadone-damaged primary cell cultures

Stam, Frida; Lind, Sara Florén; Nylander, Erik; Olaniran Håkansson, Esther et al.

Part of Neuroscience Letters, 2025

• DOI for Insulin-regulated aminopeptidase inhibitor C9 restores cellular activity in methadone-damaged primary cell cultures
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Cafeteria diet and caloric restriction affect metabolic but not behavioral characteristics in male Wistar rats

Kagios, Christakis; Hetty, Susanne; Grönbladh, Alfhild; Pereira, Maria J. et al.

Part of Physiology and Behavior, 2025

• DOI for Cafeteria diet and caloric restriction affect metabolic but not behavioral characteristics in male Wistar rats
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N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands

Wannberg, Johan; Gising, Johan; Henriksson, Martin; Vo, Duc Duy et al.

Part of European Journal of Medicinal Chemistry, 2024

• DOI for N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
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Inhibition of IRAP Enhances the Expression of Pro-Cognitive Markers Drebrin and MAP2 in Rat Primary Neuronal Cells

Stam, Frida; Lind, Sara Florén; Nylander, Erik; Olaniran, Esther et al.

Part of International Journal of Molecular Sciences, 2024

• DOI for Inhibition of IRAP Enhances the Expression of Pro-Cognitive Markers Drebrin and MAP2 in Rat Primary Neuronal Cells
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Revisiting Opioid Toxicity: Cellular Effects of Six Commonly Used Opioids

Nylander, Erik; Stam, Frida; Katila, Lenka; Zelleroth, Sofia et al.

Part of Scandinavian Journal of Pain, 2024

• DOI for Revisiting Opioid Toxicity: Cellular Effects of Six Commonly Used Opioids
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The decanoate esters of nandrolone, testosterone, and trenbolone induce steroid specific memory impairment and somatic effects in the male rat

Zelleroth, Sofia; Stam, Frida; Nylander, Erik; Ellinor, Kjellgren et al.

Part of Hormones and Behavior, 2024

• DOI for The decanoate esters of nandrolone, testosterone, and trenbolone induce steroid specific memory impairment and somatic effects in the male rat
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Acute caffeine differently affects risk-taking and the expression of BDNF and of adenosine and opioid receptors in rats with high or low anxiety-like behavior

Florén Lind, Sara; Stam, Frida; Zelleroth, Sofia; Meurling, Evelina et al.

Part of Pharmacology, Biochemistry and Behavior, 2023

• DOI for Acute caffeine differently affects risk-taking and the expression of BDNF and of adenosine and opioid receptors in rats with high or low anxiety-like behavior
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Acute low dose caffeine affects behavior profile and activity, an examination of male rats with high or low anxiety-like behavior

Florén Lind, Sara; Stam, Frida; Zelleroth, Sofia; Frick, Andreas et al.

Part of Behavioural Brain Research, 2023

• DOI for Acute low dose caffeine affects behavior profile and activity, an examination of male rats with high or low anxiety-like behavior
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Hydrogen Peroxide Induced Toxicity Is Reversed by the Macrocyclic IRAP-Inhibitor HA08 in Primary Hippocampal Cell Cultures

Stam, Frida; Lind, Sara Florén; Schroff, Anja; Zelleroth, Sofia et al.

Part of Current Issues in Molecular Biology, p. 5000-5012, 2022

• DOI for Hydrogen Peroxide Induced Toxicity Is Reversed by the Macrocyclic IRAP-Inhibitor HA08 in Primary Hippocampal Cell Cultures
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Nandrolone decanoate and testosterone undecanoate differently affect stress hormones, neurotransmitter systems, and general activity in the male rat

Zelleroth, Sofia; Nylander, Erik; Kjellgren, Ellinor; Gröndbladh, Alfhild et al.

Part of Behavioural Brain Research, 2022

• DOI for Nandrolone decanoate and testosterone undecanoate differently affect stress hormones, neurotransmitter systems, and general activity in the male rat
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The effects of morphine, methadone, and fentanyl on mitochondria: A live cell imaging study

Nylander, Erik; Zelleroth, Sofia; Nyberg, Fred; Grönbladh, Alfhild et al.

Part of Brain Research Bulletin, p. 126-134, 2021

• DOI for The effects of morphine, methadone, and fentanyl on mitochondria: A live cell imaging study

Assessing Cell Viability Effects of Opioids in Primary Cortical Cells from Rat

Grönbladh, Alfhild; Nylander, Erik; Zelleroth, Sofia; Hallberg, Mathias

Part of Methods in Molecular Biology, p. 171-180, 2021

• DOI for Assessing Cell Viability Effects of Opioids in Primary Cortical Cells from Rat

N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands

Wannberg, Johan; Gising, Johan; Lindman, Jens; Salander, Jessica et al.

Part of Bioorganic & Medicinal Chemistry, 2021

• DOI for N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands

Structurally different anabolic androgenic steroids reduce neurite outgrowth and neuronal viability in primary rat cortical cell cultures

Zelleroth, Sofia; Nylander, Erik; Örtenblad, Axel; Stam, Frida et al.

Part of Journal of Steroid Biochemistry and Molecular Biology, 2021

• DOI for Structurally different anabolic androgenic steroids reduce neurite outgrowth and neuronal viability in primary rat cortical cell cultures
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Insulin-regulated aminopeptidase inhibitor-mediated increases in dendritic spine density are facilitated by glucose uptake

Seyer, Benjamin; Diwakarla, Shanti; Burns, Peta; Hallberg, Anders et al.

Part of Journal of Neurochemistry, p. 485-494, 2020

• DOI for Insulin-regulated aminopeptidase inhibitor-mediated increases in dendritic spine density are facilitated by glucose uptake

Anabolic androgenic steroids exert a selective remodeling of the plasma lipidome that mirrors the decrease of the de novo lipogenesis in the liver

Balgoma, David; Zelleroth, Sofia; Grönbladh, Alfhild; Hallberg, Mathias et al.

Part of Metabolomics, 2020

• DOI for Anabolic androgenic steroids exert a selective remodeling of the plasma lipidome that mirrors the decrease of the de novo lipogenesis in the liver
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GABA _B receptor intracellular signaling: novel pathways for depressive disorder treatment?

Korczak, Maciej; Kurowski, Przemysław; Leśniak, Anna; Grönbladh, Alfhild et al.

Part of European Journal of Pharmacology, 2020

• DOI for GABA _B receptor intracellular signaling: novel pathways for depressive disorder treatment?

Growth hormone increases dendritic spine density in primary hippocampal cell cultures

Nylander, Erik; Zelleroth, Sofia; Stam, Frida; Nyberg, Fred et al.

Part of Growth Hormone & IGF Research, p. 42-47, 2020

• DOI for Growth hormone increases dendritic spine density in primary hippocampal cell cultures

Toxic Impact of Anabolic Androgenic Steroids in Primary Rat Cortical Cell Cultures

Zelleroth, Sofia; Nylander, Erik; Nyberg, Fred; Grönbladh, Alfhild et al.

Part of Neuroscience, p. 172-183, 2019

• DOI for Toxic Impact of Anabolic Androgenic Steroids in Primary Rat Cortical Cell Cultures
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Expression and regulation of CYP17A1 and 3β-hydroxysteroid dehydrogenase in cells of the nervous system: potential effects of vitamin D on brain steroidogenesis

Emanuelsson, Ida; Almokhtar, Mokhtar; Wikvall, Kjell; Grönbladh, Alfhild et al.

Part of Neurochemistry International, p. 46-55, 2018

• DOI for Expression and regulation of CYP17A1 and 3β-hydroxysteroid dehydrogenase in cells of the nervous system: potential effects of vitamin D on brain steroidogenesis

The Protective and Restorative Effects of Growth Hormone and Insulin-Like Growth Factor-1 on Methadone-Induced Toxicity In Vitro

Nylander, Erik; Zelleroth, Sofia; Nyberg, Fred; Grönbladh, Alfhild et al.

Part of International Journal of Molecular Sciences, p. 1-16, 2018

• DOI for The Protective and Restorative Effects of Growth Hormone and Insulin-Like Growth Factor-1 on Methadone-Induced Toxicity In Vitro
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Chronic administration of morphine using mini-osmotic pumps affects spatial memory in the male rat

Brolin, Erika; Zelleroth, Sofia; Jonsson, Anna; Hallberg, Mathias et al.

Part of Pharmacology, Biochemistry and Behavior, p. 1-8, 2018

• DOI for Chronic administration of morphine using mini-osmotic pumps affects spatial memory in the male rat

The mRNA expression of insulin-like growth factor-1 (Igf1) is decreased in the rat frontal cortex following gamma-hydroxybutyrate (GHB) administration

Brolin, Erika; Johansson, Jenny; Zelleroth, Sofia; Diwakarla, Shanti et al.

Part of Neuroscience Letters, p. 15-20, 2017

• DOI for The mRNA expression of insulin-like growth factor-1 (Igf1) is decreased in the rat frontal cortex following gamma-hydroxybutyrate (GHB) administration

Growth hormone is protective against acute methadone-induced toxicity by modulating the NMDA receptor complex

Nylander, Erik; Grönbladh, Alfhild; Zelleroth, Sofia; Diwakarla, Shanti et al.

Part of Neuroscience, p. 538-547, 2016

• DOI for Growth hormone is protective against acute methadone-induced toxicity by modulating the NMDA receptor complex

Binding to and Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Macrocyclic Disulfides Enhances Spine Density

Diwakarla, Shanti; Nylander, Erik; Grönbladh, Alfhild; Reddy Vanga, Sudarsana et al.

Part of Molecular Pharmacology, p. 413-424, 2016

• DOI for Binding to and Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Macrocyclic Disulfides Enhances Spine Density

Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures

Diwakarla, Shanti; Nylander, Erik; Grönbladh, Alfhild; Vanga, Sudarsana Reddy et al.

Part of ACS Chemical Neuroscience, p. 1383-1392, 2016

• DOI for Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures

Effects of growth hormone on brain function: new routes for the delivery of the hormone into the brain

Lai, Zhennan; Grönbladh, Alfhild; Hallberg, Mathias; Nyberg, Fred

Part of Amino Acids, p. 633-634, 2016

Genetic susceptibility to postherniotomy pain. The influence of polymorphisms in the Mu opioid receptor, TNF-alpha, GRIK3, GCH1, BDNF and CACNA2D2 genes

Kalliomäki, Maija-Liisa; Sandblom, Gabriel; Hallberg, Mathias; Grönbladh, Alfhild et al.

Part of Scandinavian Journal of Pain, p. 1-6, 2016

• DOI for Genetic susceptibility to postherniotomy pain. The influence of polymorphisms in the Mu opioid receptor, TNF-alpha, GRIK3, GCH1, BDNF and CACNA2D2 genes

[(35)S]GTPγS autoradiography for studies of opioid receptor functionality

Grönbladh, Alfhild; Hallberg, Mathias

Part of Methods in Molecular Biology, p. 169-176, 2015

• DOI for [(35)S]GTPγS autoradiography for studies of opioid receptor functionality

Serotonin receptor gene (5HT-2A) polymorphism is associated with provoked vestibulodynia and comorbid symptoms of pain

Heddini, Ulrika; Bohm-Starke, Nina; Grönbladh, Alfhild; Nyberg, Fred et al.

Part of Journal of Sexual Medicine, p. 3064-3071, 2014

• DOI for Serotonin receptor gene (5HT-2A) polymorphism is associated with provoked vestibulodynia and comorbid symptoms of pain

Administration of growth hormone and nandrolone decanoate alters mRNA expression of the GABAB receptor subunits as well as of the GH receptor, IGF-1, and IGF-2 in rat brain.

Grönbladh, Alfhild; Johansson, Jenny; Nyberg, Fred; Hallberg, Mathias

Part of Growth Hormone & IGF Research, p. 60-66, 2014

• DOI for Administration of growth hormone and nandrolone decanoate alters mRNA expression of the GABAB receptor subunits as well as of the GH receptor, IGF-1, and IGF-2 in rat brain.

Gamma-Hydroxybutyrate (GHB) induces cognitive deficits and affects GABA_B receptors and IGF-1 receptors in male rats

Johansson, Jenny; Grönbladh, Alfhild; Hallberg, Mathias

Part of Behavioural Brain Research, p. 164-174, 2014

• DOI for Gamma-Hydroxybutyrate (GHB) induces cognitive deficits and affects GABA_B receptors and IGF-1 receptors in male rats

A118G polymorphism in the μ-opioid receptor gene and levels of β-endorphin are associated with provoked vestibulodynia and pressure pain sensitivity

Heddini, Ulrika; Johannesson, Ulrika; Grönbladh, Alfhild; Nyberg, Fred et al.

Part of Scandinavian Journal of Pain, p. 10-16, 2014

• DOI for A118G polymorphism in the μ-opioid receptor gene and levels of β-endorphin are associated with provoked vestibulodynia and pressure pain sensitivity

Recombinant human growth hormone improves cognitive capacity in a pain patient exposed to chronic opioids

Rhodin, Annika; von Ehren, Michaela; Skottheim, B; Grönbladh, Alfhild et al.

Part of Acta Anaesthesiologica Scandinavica, p. 759-765, 2014

• DOI for Recombinant human growth hormone improves cognitive capacity in a pain patient exposed to chronic opioids

Combined analysis of circulating β-endorphin with gene polymorphisms in OPRM1, CACNAD2 and ABCB1 reveals correlation with pain, opioid sensitivity and opioid-related side effects

Rhodin, Annica; Gröndbladh, Alfhild; Ginya, Harumi; NIlsson, Kent W et al.

Part of Molecular Brain, 2013

• DOI for Combined analysis of circulating β-endorphin with gene polymorphisms in OPRM1, CACNAD2 and ABCB1 reveals correlation with pain, opioid sensitivity and opioid-related side effects
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The impact of nandrolone decanoate and growth hormone on biosynthesis of steroids in rats

Grönbladh, Alfhild; Johansson, Jenny; Kushnir, Mark M; Bergquist, Jonas et al.

Part of Steroids, p. 1192-1199, 2013

• DOI for The impact of nandrolone decanoate and growth hormone on biosynthesis of steroids in rats

GH (Growth hormone) improves spatial memory and reverses certain anabolic androgenic steroid-induced effects in intact rats

Grönbladh, Alfhild; Johansson, Jenny; Nöstl, Anatole; Nyberg, Fred J et al.

Part of Journal of Endocrinology, p. 31-41, 2013

• DOI for GH (Growth hormone) improves spatial memory and reverses certain anabolic androgenic steroid-induced effects in intact rats

Recombinant Human Growth Hormone Affects the Density and Functionality of GABA_B receptors in the Male Rat Brain

Grönbladh, Alfhild; Johansson, Jenny; Nyberg, Fred; Hallberg, Mathias

Part of Neuroendocrinology, p. 203-211, 2013

• DOI for Recombinant Human Growth Hormone Affects the Density and Functionality of GABA_B receptors in the Male Rat Brain

Application of in vitro [(35)S]GTPγ-S autoradiography in studies of growth hormone effects on opioid receptors in the male rat brain

Johansson, Jenny; Grönbladh, Alfhild; Nyberg, Fred; Hallberg, Mathias

Part of Brain Research Bulletin, p. 100-106, 2013

• DOI for Application of in vitro [(35)S]GTPγ-S autoradiography in studies of growth hormone effects on opioid receptors in the male rat brain

The A118G Single Nucleotide Polymorphism of Human μ–Opioid Receptor Gene and Use of Labor Analgesia

Dabo Pettersson, Fatimah; Grönblad, Alhild; Nyberg, Fred; Sundström-Poromaa, Inger et al.

Part of Reproductive Sciences, p. 962-967, 2012

• DOI for The A118G Single Nucleotide Polymorphism of Human μ–Opioid Receptor Gene and Use of Labor Analgesia

GCH1-polymorphism and pain sensitivity among women with provoked vestibulodynia

Heddini, Ulrika; Bohm-Starke, Nina; Grönbladh, Alfhild; Nyberg, Fred et al.

Part of Molecular Pain, p. 68, 2012

• DOI for GCH1-polymorphism and pain sensitivity among women with provoked vestibulodynia
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The expression of growth hormone receptor gene transcript in the prefrontal cortex is affected in male mice with diabetes-induced learning impairments

Enhamre, Erika; Carlsson, Anna; Grönbladh, Alfhild; Watanabe, Hiroyuki et al.

Part of Neuroscience Letters, p. 82-86, 2012

• DOI for The expression of growth hormone receptor gene transcript in the prefrontal cortex is affected in male mice with diabetes-induced learning impairments

Different SNP combinations in the GCH1 gene and use of labor analgesia

Dabo, Fatimah; Grönbladh, Alfhild; Nyberg, Fred; Sundström Poromaa, Inger et al.

Part of Molecular Pain, p. 41, 2010

• DOI for Different SNP combinations in the GCH1 gene and use of labor analgesia

The neurobiology and addiction potential of anabolic androgenic steroids and the effects of growth hormone

Grönbladh, Alfhild; Nylander, Erik; Hallberg, Mathias

Part of Brain Research Bulletin, p. 127-137, 2016

• DOI for The neurobiology and addiction potential of anabolic androgenic steroids and the effects of growth hormone

GTPγS-Autoradiography for Studies of Opioid Receptor Functionality

Grönbladh, Alfhild; Hallberg, Mathias

Part of Opioid Receptors, p. 109-116, Humana Press, 2020

• DOI for GTPγS-Autoradiography for Studies of Opioid Receptor Functionality

Growth Hormone and Anabolic Androgenic Steroids: Effects on Neurochemistry and Cognition

Grönbladh, Alfhild

2013

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Gamma-Hydroxybutyrate (GHB) elevates Met-enkephalin-Arg⁶Phe⁷ (MEAP) levels in the frontal cortex of the male rat brain

Johansson, Jenny; Brolin, Erika; Grönbladh, Alfhild; Nyberg, Fred et al.

Mitochondrial function and membrane integrity: an in vitro comparison between six commonly used opioids

Nylander, Erik; Katila, Lenka; Zelleroth, Sofia; Birgersson, Jennifer et al.