Zhe Jin
Researcher at Department of Medical Cell Biology; Research group Bryndis Birnir
- E-mail:
- zhe.jin@mcb.uu.se
- Visiting address:
- Husargatan 3
751 23 Uppsala - Postal address:
- Box 571
75123 Uppsala
Short presentation
Biography
Academic qualifications:
2018 Docent in Physiology, Uppsala University
2006 PhD in Experimental Neuroscience, Dept. of Clinical Neuroscience, Karolinska Institutet
2001 Bachelor of Medicine, Shanghai Medical College of Fudan University
Current positions:
2020 - ongoing: Researcher, Dept. of Medical Cell Biology, Uppsala University
2022 - ongoing: Coordinator of Master's Programme in Biomedicine, Uppsala University
2025 - ongoing: Neuroscience Research Track leader, Disciplinary Domain of Medicine and Pharmacy, Uppsala University
Publications
Selection of publications
-
Part of Frontiers in Cellular Neuroscience, 2025
- DOI for Rodent islet amyloid polypeptide (IAPP) selectively enhances GABAA receptor-mediated neuronal inhibition in mouse ventral but not dorsal hippocampal dentate gyrus granule cells
- Download full text (pdf) of Rodent islet amyloid polypeptide (IAPP) selectively enhances GABAA receptor-mediated neuronal inhibition in mouse ventral but not dorsal hippocampal dentate gyrus granule cells
-
Part of EBioMedicine, 2024
- DOI for GABA-mediated inhibition of human CD4+ T cell functions is enhanced by insulin but impaired by high glucose levels
- Download full text (pdf) of GABA-mediated inhibition of human CD4+ T cell functions is enhanced by insulin but impaired by high glucose levels
-
GABA signalling in human pancreatic islets
Part of Frontiers in Endocrinology, 2023
- DOI for GABA signalling in human pancreatic islets
- Download full text (pdf) of GABA signalling in human pancreatic islets
-
Part of Frontiers in Molecular Neuroscience, 2022
- DOI for ZEB2 haploinsufficient Mowat-Wilson syndrome induced pluripotent stem cells show disrupted GABAergic transcriptional regulation and function
- Download full text (pdf) of ZEB2 haploinsufficient Mowat-Wilson syndrome induced pluripotent stem cells show disrupted GABAergic transcriptional regulation and function
-
Part of Acta Physiologica, 2021
- DOI for Insulin differentially modulates GABA signalling in hippocampal neurons and, in an age-dependent manner, normalizes GABA-activated currents in the tg-APPSwe mouse model of Alzheimer's disease
- Download full text (pdf) of Insulin differentially modulates GABA signalling in hippocampal neurons and, in an age-dependent manner, normalizes GABA-activated currents in the tg-APPSwe mouse model of Alzheimer's disease
-
Part of Hippocampus, p. 1146-1157, 2020
- DOI for Tonic GABA-activated synaptic and extrasynaptic currents in dentate gyrus granule cells and CA3 pyramidal neurons along the mouse hippocampal dorsoventral axis
- Download full text (pdf) of Tonic GABA-activated synaptic and extrasynaptic currents in dentate gyrus granule cells and CA3 pyramidal neurons along the mouse hippocampal dorsoventral axis
-
Part of Journal of Neuroimmunology, 2019
- DOI for Interferon-gamma potentiates GABA(A) receptor-mediated inhibitory currents in rat hippocampal CA1 pyramidal neurons
- Download full text (pdf) of Interferon-gamma potentiates GABA(A) receptor-mediated inhibitory currents in rat hippocampal CA1 pyramidal neurons
-
Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells
Part of EBioMedicine, 2018
- DOI for Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells
- Download full text (pdf) of Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells
-
Part of EBioMedicine, p. 283-294, 2018
- DOI for GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4+ T Cells and Is Immunosuppressive in Type 1 Diabetes
- Download full text (pdf) of GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4+ T Cells and Is Immunosuppressive in Type 1 Diabetes
-
Part of BMC Pharmacology & Toxicology, 2017
- DOI for Liraglutide modulates GABAergic signaling in rat hippocampal CA3 pyramidal neurons predominantly by presynaptic mechanism
- Download full text (pdf) of Liraglutide modulates GABAergic signaling in rat hippocampal CA3 pyramidal neurons predominantly by presynaptic mechanism
-
Part of Acta Biomaterialia, p. 211-220, 2016
-
GABAergic signalling in the immune system
Part of Acta Physiologica, p. 819-827, 2015
-
GABA is an effective immunomodulatory molecule
Part of Amino Acids, p. 87-94, 2013
-
Part of PLOS ONE, 2012
- DOI for GABA-A Channel Subunit Expression in Human Glioma Correlates with Tumor Histology and Clinical Outcome
- Download full text (pdf) of GABA-A Channel Subunit Expression in Human Glioma Correlates with Tumor Histology and Clinical Outcome
-
gamma-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes
Part of Diabetologia, p. 1985-1994, 2012
-
GABA-activated single-channel and tonic currents in rat brain slices
Part of Journal of Visualized Experiments, 2011
-
Insulin reduces neuronal excitability by turning on GABA(A) channels that generate tonic current
Part of PLOS ONE, 2011
Recent publications
-
GABAA receptor agonists modulate intracellular Ca2+ levels in activated human CD4+ T cells
Part of Frontiers in Immunology, 2026
- DOI for GABAA receptor agonists modulate intracellular Ca2+ levels in activated human CD4+ T cells
- Download full text (pdf) of GABAA receptor agonists modulate intracellular Ca2+ levels in activated human CD4+ T cells
-
Part of Frontiers in Cellular Neuroscience, 2025
- DOI for GLP-1 selectively enhances tonic GABAA receptor-mediated currents in mouse dentate gyrus granule cells of the ventral hippocampus
- Download full text (pdf) of GLP-1 selectively enhances tonic GABAA receptor-mediated currents in mouse dentate gyrus granule cells of the ventral hippocampus
-
Part of Frontiers in Immunology, 2025
- DOI for Inhibition of the Na+-glucose transporter SGLT2 reduces glucose uptake and IFNγ release from activated human CD4+ T cells
- Download full text (pdf) of Inhibition of the Na+-glucose transporter SGLT2 reduces glucose uptake and IFNγ release from activated human CD4+ T cells
-
Part of Journal of Alzheimer's Disease, p. 420-428, 2025
-
Part of Frontiers in Cellular Neuroscience, 2025
- DOI for Rodent islet amyloid polypeptide (IAPP) selectively enhances GABAA receptor-mediated neuronal inhibition in mouse ventral but not dorsal hippocampal dentate gyrus granule cells
- Download full text (pdf) of Rodent islet amyloid polypeptide (IAPP) selectively enhances GABAA receptor-mediated neuronal inhibition in mouse ventral but not dorsal hippocampal dentate gyrus granule cells
All publications
Articles in journal
-
GABAA receptor agonists modulate intracellular Ca2+ levels in activated human CD4+ T cells
Part of Frontiers in Immunology, 2026
- DOI for GABAA receptor agonists modulate intracellular Ca2+ levels in activated human CD4+ T cells
- Download full text (pdf) of GABAA receptor agonists modulate intracellular Ca2+ levels in activated human CD4+ T cells
-
Part of Frontiers in Cellular Neuroscience, 2025
- DOI for GLP-1 selectively enhances tonic GABAA receptor-mediated currents in mouse dentate gyrus granule cells of the ventral hippocampus
- Download full text (pdf) of GLP-1 selectively enhances tonic GABAA receptor-mediated currents in mouse dentate gyrus granule cells of the ventral hippocampus
-
Part of Frontiers in Immunology, 2025
- DOI for Inhibition of the Na+-glucose transporter SGLT2 reduces glucose uptake and IFNγ release from activated human CD4+ T cells
- Download full text (pdf) of Inhibition of the Na+-glucose transporter SGLT2 reduces glucose uptake and IFNγ release from activated human CD4+ T cells
-
Part of Journal of Alzheimer's Disease, p. 420-428, 2025
-
Part of Frontiers in Cellular Neuroscience, 2025
- DOI for Rodent islet amyloid polypeptide (IAPP) selectively enhances GABAA receptor-mediated neuronal inhibition in mouse ventral but not dorsal hippocampal dentate gyrus granule cells
- Download full text (pdf) of Rodent islet amyloid polypeptide (IAPP) selectively enhances GABAA receptor-mediated neuronal inhibition in mouse ventral but not dorsal hippocampal dentate gyrus granule cells
-
PET imaging of GABAA receptors in pancreatic islets by [11C]flumazenil
Part of EJNMMI Research, 2024
- DOI for PET imaging of GABAA receptors in pancreatic islets by [11C]flumazenil
- Download full text (pdf) of PET imaging of GABAA receptors in pancreatic islets by [11C]flumazenil
-
Part of EBioMedicine, 2024
- DOI for GABA-mediated inhibition of human CD4+ T cell functions is enhanced by insulin but impaired by high glucose levels
- Download full text (pdf) of GABA-mediated inhibition of human CD4+ T cell functions is enhanced by insulin but impaired by high glucose levels
-
Part of Journal of Medicinal Chemistry, p. 1380-1425, 2023
- DOI for Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa
- Download full text (pdf) of Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa
-
Part of Journal of Medicinal Chemistry, p. 3968-3994, 2023
- DOI for New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus
- Download full text (pdf) of New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus
-
Part of Frontiers in Molecular Neuroscience, 2022
- DOI for ZEB2 haploinsufficient Mowat-Wilson syndrome induced pluripotent stem cells show disrupted GABAergic transcriptional regulation and function
- Download full text (pdf) of ZEB2 haploinsufficient Mowat-Wilson syndrome induced pluripotent stem cells show disrupted GABAergic transcriptional regulation and function
-
Part of Acta Physiologica, 2021
- DOI for Insulin differentially modulates GABA signalling in hippocampal neurons and, in an age-dependent manner, normalizes GABA-activated currents in the tg-APPSwe mouse model of Alzheimer's disease
- Download full text (pdf) of Insulin differentially modulates GABA signalling in hippocampal neurons and, in an age-dependent manner, normalizes GABA-activated currents in the tg-APPSwe mouse model of Alzheimer's disease
-
Neocortex- and hippocampus-specific deletion of Gabrg2 causes temperature-dependent seizures in mice
Part of Cell Death and Disease, 2021
- DOI for Neocortex- and hippocampus-specific deletion of Gabrg2 causes temperature-dependent seizures in mice
- Download full text (pdf) of Neocortex- and hippocampus-specific deletion of Gabrg2 causes temperature-dependent seizures in mice
-
Part of American Journal of Human Genetics, p. 739-748, 2021
- DOI for Monoallelic and bi-allelic variants in NCDN cause neurodevelopmental delay, intellectual disability, and epilepsy
- Download full text (pdf) of Monoallelic and bi-allelic variants in NCDN cause neurodevelopmental delay, intellectual disability, and epilepsy
-
Part of Frontiers in Psychiatry, 2020
- DOI for Continuous High Frequency Deep Brain Stimulation of the Rat Anterior Insula Attenuates the Relapse Post Withdrawal and Strengthens the Extinction of Morphine Seeking
- Download full text (pdf) of Continuous High Frequency Deep Brain Stimulation of the Rat Anterior Insula Attenuates the Relapse Post Withdrawal and Strengthens the Extinction of Morphine Seeking
-
Part of Frontiers in Pharmacology, 2020
- DOI for The Glucagon-Like Peptide-1 Analogue Liraglutide Reduces Seizures Susceptibility, Cognition Dysfunction and Neuronal Apoptosis in a Mouse Model of Dravet Syndrome
- Download full text (pdf) of The Glucagon-Like Peptide-1 Analogue Liraglutide Reduces Seizures Susceptibility, Cognition Dysfunction and Neuronal Apoptosis in a Mouse Model of Dravet Syndrome
-
Increased Alcohol Consumption in Mice Lacking Sodium Bicarbonate Transporter NBCn1
Part of Scientific Reports, 2020
- DOI for Increased Alcohol Consumption in Mice Lacking Sodium Bicarbonate Transporter NBCn1
- Download full text (pdf) of Increased Alcohol Consumption in Mice Lacking Sodium Bicarbonate Transporter NBCn1
-
Part of Hippocampus, p. 1146-1157, 2020
- DOI for Tonic GABA-activated synaptic and extrasynaptic currents in dentate gyrus granule cells and CA3 pyramidal neurons along the mouse hippocampal dorsoventral axis
- Download full text (pdf) of Tonic GABA-activated synaptic and extrasynaptic currents in dentate gyrus granule cells and CA3 pyramidal neurons along the mouse hippocampal dorsoventral axis
-
Part of International Journal of Molecular Sciences, 2020
- DOI for GABA(A) Receptor-Mediated Currents and Hormone mRNAs in Cells Expressing More Than One Hormone Transcript in Intact Human Pancreatic Islets
- Download full text (pdf) of GABA(A) Receptor-Mediated Currents and Hormone mRNAs in Cells Expressing More Than One Hormone Transcript in Intact Human Pancreatic Islets
-
Ataxia in Patients With Bi-Allelic NFASC Mutations and Absence of Full-Length NF186
Part of Frontiers in Genetics, 2019
- DOI for Ataxia in Patients With Bi-Allelic NFASC Mutations and Absence of Full-Length NF186
- Download full text (pdf) of Ataxia in Patients With Bi-Allelic NFASC Mutations and Absence of Full-Length NF186
-
Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers
Part of International Journal of Molecular Sciences, 2019
- DOI for Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers
- Download full text (pdf) of Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers
-
Part of Journal of Neuroimmunology, 2019
- DOI for Interferon-gamma potentiates GABA(A) receptor-mediated inhibitory currents in rat hippocampal CA1 pyramidal neurons
- Download full text (pdf) of Interferon-gamma potentiates GABA(A) receptor-mediated inhibitory currents in rat hippocampal CA1 pyramidal neurons
-
Part of Neurobiology of Disease, 2019
- DOI for Transcriptomes of Dravet syndrome iPSC derived GABAergic cells reveal dysregulated pathways for chromatin remodeling and neurodevelopment
- Download full text (pdf) of Transcriptomes of Dravet syndrome iPSC derived GABAergic cells reveal dysregulated pathways for chromatin remodeling and neurodevelopment
-
Part of PLOS ONE, 2018
- DOI for Expression of calcium release-activated and voltage-gated calcium channels genes in peripheral blood mononuclear cells is altered in pregnancy and in type 1 diabetes
- Download full text (pdf) of Expression of calcium release-activated and voltage-gated calcium channels genes in peripheral blood mononuclear cells is altered in pregnancy and in type 1 diabetes
-
Insulin enhances GABAA receptor-mediated inhibitory currents in rat central amygdala neurons
Part of Neuroscience Letters, p. 76-81, 2018
- DOI for Insulin enhances GABAA receptor-mediated inhibitory currents in rat central amygdala neurons
- Download full text (pdf) of Insulin enhances GABAA receptor-mediated inhibitory currents in rat central amygdala neurons
-
Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells
Part of EBioMedicine, 2018
- DOI for Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells
- Download full text (pdf) of Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells
-
Part of EBioMedicine, p. 283-294, 2018
- DOI for GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4+ T Cells and Is Immunosuppressive in Type 1 Diabetes
- Download full text (pdf) of GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4+ T Cells and Is Immunosuppressive in Type 1 Diabetes
-
Effects of GABA(B) receptors in the insula on recognition memory observed with intellicage
Part of Behavioral and Brain Functions, 2017
- DOI for Effects of GABA(B) receptors in the insula on recognition memory observed with intellicage
- Download full text (pdf) of Effects of GABA(B) receptors in the insula on recognition memory observed with intellicage
-
Part of Neuroscience, p. 300-321, 2017
- DOI for Characterization of the gamma-aminobutyric acid signaling system in the zebrafish (danio rerio hamilton) central nervous system by reverse transcription-quantitative polymerase chain reaction
- Download full text (pdf) of Characterization of the gamma-aminobutyric acid signaling system in the zebrafish (danio rerio hamilton) central nervous system by reverse transcription-quantitative polymerase chain reaction
-
Part of BMC Pharmacology & Toxicology, 2017
- DOI for Liraglutide modulates GABAergic signaling in rat hippocampal CA3 pyramidal neurons predominantly by presynaptic mechanism
- Download full text (pdf) of Liraglutide modulates GABAergic signaling in rat hippocampal CA3 pyramidal neurons predominantly by presynaptic mechanism
-
Part of Journal of Neuroimmunology, p. 51-58, 2017
-
Part of Acta Biomaterialia, p. 211-220, 2016
-
Part of Diabetes, p. 79-89, 2015
- DOI for GLP-1 and Exendin-4 Transiently Enhance GABA(A) Receptor-Mediated Synaptic and Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons
- Download full text (pdf) of GLP-1 and Exendin-4 Transiently Enhance GABA(A) Receptor-Mediated Synaptic and Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons
-
Part of Acta Physiologica, p. 91-91, 2015
-
Insulin modulates GABAA receptor-mediated neuronal inhibition in rat hippocampus and amygdala
Part of Acta Physiologica, p. 90-90, 2015
-
Part of Acta Physiologica, p. 89-90, 2015
-
Part of Acta Physiologica, p. 575-585, 2015
-
Part of PLOS ONE, 2015
- DOI for The GLP-1 Receptor Agonist Exendin-4 and Diazepam Differentially Regulate GABAA Receptor-Mediated Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons
- Download full text (pdf) of The GLP-1 Receptor Agonist Exendin-4 and Diazepam Differentially Regulate GABAA Receptor-Mediated Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons
-
Part of European Journal of Pharmacology, p. 101-107, 2015
-
Part of Frontiers in Cellular Neuroscience, p. 11, 2014
-
Insulin modulates GABA(A) receptor-mediated inhibition in rat amygdala neurons
Part of Acta Physiologica, p. 83-83, 2014
-
Part of Acta Physiologica, p. 83-83, 2014
-
GABA-A receptor subunit expression in human peripheral blood mononuclear cells
Part of Acta Physiologica, p. 86-86, 2014
-
Part of Acta Physiologica, p. 100-100, 2014
-
Part of Frontiers in Cellular Neuroscience, 2014
-
Part of Frontiers in Cellular Neuroscience, p. 288, 2014
-
GABA is an effective immunomodulatory molecule
Part of Amino Acids, p. 87-94, 2013
-
Part of PLOS ONE, 2013
- DOI for In Intact Islets Interstitial GABA Activates GABA(A) Receptors That Generate Tonic Currents in alpha-Cells
- Download full text (pdf) of In Intact Islets Interstitial GABA Activates GABA(A) Receptors That Generate Tonic Currents in alpha-Cells
-
Part of Frontiers in Cellular Neuroscience, 2012
- DOI for Selective Changes of GABA(A) Channel Subunit mRNAs in the Hippocampus and Orbitofrontal Cortex but not in Prefrontal Cortex of Human Alcoholics
- Download full text (pdf) of Selective Changes of GABA(A) Channel Subunit mRNAs in the Hippocampus and Orbitofrontal Cortex but not in Prefrontal Cortex of Human Alcoholics
-
Part of European Journal of Neurology, p. 67-67, 2012
-
Part of PLOS ONE, 2012
- DOI for GABA-A Channel Subunit Expression in Human Glioma Correlates with Tumor Histology and Clinical Outcome
- Download full text (pdf) of GABA-A Channel Subunit Expression in Human Glioma Correlates with Tumor Histology and Clinical Outcome
-
Different subtypes of GABA-A receptors are expressed in human, mouse and rat T lymphocytes
Part of PLOS ONE, 2012
- DOI for Different subtypes of GABA-A receptors are expressed in human, mouse and rat T lymphocytes
- Download full text (pdf) of Different subtypes of GABA-A receptors are expressed in human, mouse and rat T lymphocytes
-
Part of PLoS pathogens, 2012
- DOI for GABAergic Signaling Is Linked to a Hypermigratory Phenotype in Dendritic Cells Infected by Toxoplasma gondii
- Download full text (pdf) of GABAergic Signaling Is Linked to a Hypermigratory Phenotype in Dendritic Cells Infected by Toxoplasma gondii
-
gamma-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes
Part of Diabetologia, p. 1985-1994, 2012
-
Part of DNA and Cell Biology, p. 520-523, 2012
-
Part of Acta Oto-Laryngologica, p. 261-265, 2012
-
GABA-activated single-channel and tonic currents in rat brain slices
Part of Journal of Visualized Experiments, 2011
-
Part of Acta Oto-Laryngologica, p. 136-141, 2011
-
Part of Brain Research, p. 41-49, 2011
-
Insulin reduces neuronal excitability by turning on GABA(A) channels that generate tonic current
Part of PLOS ONE, 2011
-
Part of Molecular Immunology, p. 399-407, 2011
Articles, review/survey
-
GABA signalling in human pancreatic islets
Part of Frontiers in Endocrinology, 2023
- DOI for GABA signalling in human pancreatic islets
- Download full text (pdf) of GABA signalling in human pancreatic islets
-
All Roads Lead to Rome?: Genes Causing Dravet Syndrome and Dravet Syndrome-Like Phenotypes
Part of Frontiers in Neurology, 2022
- DOI for All Roads Lead to Rome?: Genes Causing Dravet Syndrome and Dravet Syndrome-Like Phenotypes
- Download full text (pdf) of All Roads Lead to Rome?: Genes Causing Dravet Syndrome and Dravet Syndrome-Like Phenotypes
-
GABAergic signalling in the immune system
Part of Acta Physiologica, p. 819-827, 2015
Chapters in book
-
GABA is an efficient immunomodulator molecule
Part of Nerve-Driven Immunity, p. 163-173, Springer, 2012