Zhe Jin
Researcher at Department of Medical Cell Biology; Research group Bryndis Birnir
- E-mail:
- zhe.jin@mcb.uu.se
- Visiting address:
- Husargatan 3
751 23 Uppsala - Postal address:
- Box 571
75123 Uppsala
Short presentation
Biography
Academic qualifications:
2018 Docent in Physiology, Uppsala University
2006 PhD in Experimental Neuroscience, Dept. of Clinical Neuroscience, Karolinska Institutet
2001 Bachelor of Medicine, Shanghai Medical College of Fudan University
Current positions:
2020 - ongoing: Researcher, Dept. of Medical Cell Biology, Uppsala University
2022 - ongoing: Coordinator of Master's Programme in Biomedicine, Uppsala University
2025 - ongoing: Neuroscience Research Track leader, Disciplinary Domain of Medicine and Pharmacy, Uppsala University
Publications
Selection of publications
Part of Frontiers in Cellular Neuroscience, 2025
- DOI for Rodent islet amyloid polypeptide (IAPP) selectively enhances GABAA receptor-mediated neuronal inhibition in mouse ventral but not dorsal hippocampal dentate gyrus granule cells
- Download full text (pdf) of Rodent islet amyloid polypeptide (IAPP) selectively enhances GABAA receptor-mediated neuronal inhibition in mouse ventral but not dorsal hippocampal dentate gyrus granule cells
Part of EBioMedicine, 2024
- DOI for GABA-mediated inhibition of human CD4+ T cell functions is enhanced by insulin but impaired by high glucose levels
- Download full text (pdf) of GABA-mediated inhibition of human CD4+ T cell functions is enhanced by insulin but impaired by high glucose levels
GABA signalling in human pancreatic islets
Part of Frontiers in Endocrinology, 2023
- DOI for GABA signalling in human pancreatic islets
- Download full text (pdf) of GABA signalling in human pancreatic islets
Part of Frontiers in Molecular Neuroscience, 2022
- DOI for ZEB2 haploinsufficient Mowat-Wilson syndrome induced pluripotent stem cells show disrupted GABAergic transcriptional regulation and function
- Download full text (pdf) of ZEB2 haploinsufficient Mowat-Wilson syndrome induced pluripotent stem cells show disrupted GABAergic transcriptional regulation and function
Part of Acta Physiologica, 2021
- DOI for Insulin differentially modulates GABA signalling in hippocampal neurons and, in an age-dependent manner, normalizes GABA-activated currents in the tg-APPSwe mouse model of Alzheimer's disease
- Download full text (pdf) of Insulin differentially modulates GABA signalling in hippocampal neurons and, in an age-dependent manner, normalizes GABA-activated currents in the tg-APPSwe mouse model of Alzheimer's disease
Part of Hippocampus, p. 1146-1157, 2020
- DOI for Tonic GABA-activated synaptic and extrasynaptic currents in dentate gyrus granule cells and CA3 pyramidal neurons along the mouse hippocampal dorsoventral axis
- Download full text (pdf) of Tonic GABA-activated synaptic and extrasynaptic currents in dentate gyrus granule cells and CA3 pyramidal neurons along the mouse hippocampal dorsoventral axis
Part of Journal of Neuroimmunology, 2019
- DOI for Interferon-gamma potentiates GABA(A) receptor-mediated inhibitory currents in rat hippocampal CA1 pyramidal neurons
- Download full text (pdf) of Interferon-gamma potentiates GABA(A) receptor-mediated inhibitory currents in rat hippocampal CA1 pyramidal neurons
Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells
Part of EBioMedicine, 2018
- DOI for Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells
- Download full text (pdf) of Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells
Part of EBioMedicine, p. 283-294, 2018
- DOI for GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4+ T Cells and Is Immunosuppressive in Type 1 Diabetes
- Download full text (pdf) of GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4+ T Cells and Is Immunosuppressive in Type 1 Diabetes
Part of BMC Pharmacology & Toxicology, 2017
- DOI for Liraglutide modulates GABAergic signaling in rat hippocampal CA3 pyramidal neurons predominantly by presynaptic mechanism
- Download full text (pdf) of Liraglutide modulates GABAergic signaling in rat hippocampal CA3 pyramidal neurons predominantly by presynaptic mechanism
Part of Acta Biomaterialia, p. 211-220, 2016
GABAergic signalling in the immune system
Part of Acta Physiologica, p. 819-827, 2015
GABA is an effective immunomodulatory molecule
Part of Amino Acids, p. 87-94, 2013
Part of PLOS ONE, 2012
- DOI for GABA-A Channel Subunit Expression in Human Glioma Correlates with Tumor Histology and Clinical Outcome
- Download full text (pdf) of GABA-A Channel Subunit Expression in Human Glioma Correlates with Tumor Histology and Clinical Outcome
gamma-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes
Part of Diabetologia, p. 1985-1994, 2012
GABA-activated single-channel and tonic currents in rat brain slices
Part of Journal of Visualized Experiments, 2011
Insulin reduces neuronal excitability by turning on GABA(A) channels that generate tonic current
Part of PLOS ONE, 2011
Recent publications
Part of Journal of Alzheimer's Disease, p. 420-428, 2025
Part of Frontiers in Cellular Neuroscience, 2025
- DOI for Rodent islet amyloid polypeptide (IAPP) selectively enhances GABAA receptor-mediated neuronal inhibition in mouse ventral but not dorsal hippocampal dentate gyrus granule cells
- Download full text (pdf) of Rodent islet amyloid polypeptide (IAPP) selectively enhances GABAA receptor-mediated neuronal inhibition in mouse ventral but not dorsal hippocampal dentate gyrus granule cells
PET imaging of GABAA receptors in pancreatic islets by [11C]flumazenil
Part of EJNMMI Research, 2024
- DOI for PET imaging of GABAA receptors in pancreatic islets by [11C]flumazenil
- Download full text (pdf) of PET imaging of GABAA receptors in pancreatic islets by [11C]flumazenil
Part of EBioMedicine, 2024
- DOI for GABA-mediated inhibition of human CD4+ T cell functions is enhanced by insulin but impaired by high glucose levels
- Download full text (pdf) of GABA-mediated inhibition of human CD4+ T cell functions is enhanced by insulin but impaired by high glucose levels
GABA signalling in human pancreatic islets
Part of Frontiers in Endocrinology, 2023
- DOI for GABA signalling in human pancreatic islets
- Download full text (pdf) of GABA signalling in human pancreatic islets
All publications
Articles in journal
Part of Journal of Alzheimer's Disease, p. 420-428, 2025
Part of Frontiers in Cellular Neuroscience, 2025
- DOI for Rodent islet amyloid polypeptide (IAPP) selectively enhances GABAA receptor-mediated neuronal inhibition in mouse ventral but not dorsal hippocampal dentate gyrus granule cells
- Download full text (pdf) of Rodent islet amyloid polypeptide (IAPP) selectively enhances GABAA receptor-mediated neuronal inhibition in mouse ventral but not dorsal hippocampal dentate gyrus granule cells
PET imaging of GABAA receptors in pancreatic islets by [11C]flumazenil
Part of EJNMMI Research, 2024
- DOI for PET imaging of GABAA receptors in pancreatic islets by [11C]flumazenil
- Download full text (pdf) of PET imaging of GABAA receptors in pancreatic islets by [11C]flumazenil
Part of EBioMedicine, 2024
- DOI for GABA-mediated inhibition of human CD4+ T cell functions is enhanced by insulin but impaired by high glucose levels
- Download full text (pdf) of GABA-mediated inhibition of human CD4+ T cell functions is enhanced by insulin but impaired by high glucose levels
Part of Journal of Medicinal Chemistry, p. 1380-1425, 2023
- DOI for Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa
- Download full text (pdf) of Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa
Part of Journal of Medicinal Chemistry, p. 3968-3994, 2023
- DOI for New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus
- Download full text (pdf) of New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus
Part of Frontiers in Molecular Neuroscience, 2022
- DOI for ZEB2 haploinsufficient Mowat-Wilson syndrome induced pluripotent stem cells show disrupted GABAergic transcriptional regulation and function
- Download full text (pdf) of ZEB2 haploinsufficient Mowat-Wilson syndrome induced pluripotent stem cells show disrupted GABAergic transcriptional regulation and function
Part of Acta Physiologica, 2021
- DOI for Insulin differentially modulates GABA signalling in hippocampal neurons and, in an age-dependent manner, normalizes GABA-activated currents in the tg-APPSwe mouse model of Alzheimer's disease
- Download full text (pdf) of Insulin differentially modulates GABA signalling in hippocampal neurons and, in an age-dependent manner, normalizes GABA-activated currents in the tg-APPSwe mouse model of Alzheimer's disease
Neocortex- and hippocampus-specific deletion of Gabrg2 causes temperature-dependent seizures in mice
Part of Cell Death and Disease, 2021
- DOI for Neocortex- and hippocampus-specific deletion of Gabrg2 causes temperature-dependent seizures in mice
- Download full text (pdf) of Neocortex- and hippocampus-specific deletion of Gabrg2 causes temperature-dependent seizures in mice
Part of American Journal of Human Genetics, p. 739-748, 2021
- DOI for Monoallelic and bi-allelic variants in NCDN cause neurodevelopmental delay, intellectual disability, and epilepsy
- Download full text (pdf) of Monoallelic and bi-allelic variants in NCDN cause neurodevelopmental delay, intellectual disability, and epilepsy
Part of Frontiers in Psychiatry, 2020
- DOI for Continuous High Frequency Deep Brain Stimulation of the Rat Anterior Insula Attenuates the Relapse Post Withdrawal and Strengthens the Extinction of Morphine Seeking
- Download full text (pdf) of Continuous High Frequency Deep Brain Stimulation of the Rat Anterior Insula Attenuates the Relapse Post Withdrawal and Strengthens the Extinction of Morphine Seeking
Part of Frontiers in Pharmacology, 2020
- DOI for The Glucagon-Like Peptide-1 Analogue Liraglutide Reduces Seizures Susceptibility, Cognition Dysfunction and Neuronal Apoptosis in a Mouse Model of Dravet Syndrome
- Download full text (pdf) of The Glucagon-Like Peptide-1 Analogue Liraglutide Reduces Seizures Susceptibility, Cognition Dysfunction and Neuronal Apoptosis in a Mouse Model of Dravet Syndrome
Increased Alcohol Consumption in Mice Lacking Sodium Bicarbonate Transporter NBCn1
Part of Scientific Reports, 2020
- DOI for Increased Alcohol Consumption in Mice Lacking Sodium Bicarbonate Transporter NBCn1
- Download full text (pdf) of Increased Alcohol Consumption in Mice Lacking Sodium Bicarbonate Transporter NBCn1
Part of Hippocampus, p. 1146-1157, 2020
- DOI for Tonic GABA-activated synaptic and extrasynaptic currents in dentate gyrus granule cells and CA3 pyramidal neurons along the mouse hippocampal dorsoventral axis
- Download full text (pdf) of Tonic GABA-activated synaptic and extrasynaptic currents in dentate gyrus granule cells and CA3 pyramidal neurons along the mouse hippocampal dorsoventral axis
Part of International Journal of Molecular Sciences, 2020
- DOI for GABA(A) Receptor-Mediated Currents and Hormone mRNAs in Cells Expressing More Than One Hormone Transcript in Intact Human Pancreatic Islets
- Download full text (pdf) of GABA(A) Receptor-Mediated Currents and Hormone mRNAs in Cells Expressing More Than One Hormone Transcript in Intact Human Pancreatic Islets
Ataxia in Patients With Bi-Allelic NFASC Mutations and Absence of Full-Length NF186
Part of Frontiers in Genetics, 2019
- DOI for Ataxia in Patients With Bi-Allelic NFASC Mutations and Absence of Full-Length NF186
- Download full text (pdf) of Ataxia in Patients With Bi-Allelic NFASC Mutations and Absence of Full-Length NF186
Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers
Part of International Journal of Molecular Sciences, 2019
- DOI for Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers
- Download full text (pdf) of Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers
Part of Journal of Neuroimmunology, 2019
- DOI for Interferon-gamma potentiates GABA(A) receptor-mediated inhibitory currents in rat hippocampal CA1 pyramidal neurons
- Download full text (pdf) of Interferon-gamma potentiates GABA(A) receptor-mediated inhibitory currents in rat hippocampal CA1 pyramidal neurons
Part of Neurobiology of Disease, 2019
- DOI for Transcriptomes of Dravet syndrome iPSC derived GABAergic cells reveal dysregulated pathways for chromatin remodeling and neurodevelopment
- Download full text (pdf) of Transcriptomes of Dravet syndrome iPSC derived GABAergic cells reveal dysregulated pathways for chromatin remodeling and neurodevelopment
Part of PLOS ONE, 2018
- DOI for Expression of calcium release-activated and voltage-gated calcium channels genes in peripheral blood mononuclear cells is altered in pregnancy and in type 1 diabetes
- Download full text (pdf) of Expression of calcium release-activated and voltage-gated calcium channels genes in peripheral blood mononuclear cells is altered in pregnancy and in type 1 diabetes
Insulin enhances GABAA receptor-mediated inhibitory currents in rat central amygdala neurons
Part of Neuroscience Letters, p. 76-81, 2018
- DOI for Insulin enhances GABAA receptor-mediated inhibitory currents in rat central amygdala neurons
- Download full text (pdf) of Insulin enhances GABAA receptor-mediated inhibitory currents in rat central amygdala neurons
Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells
Part of EBioMedicine, 2018
- DOI for Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells
- Download full text (pdf) of Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells
Part of EBioMedicine, p. 283-294, 2018
- DOI for GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4+ T Cells and Is Immunosuppressive in Type 1 Diabetes
- Download full text (pdf) of GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4+ T Cells and Is Immunosuppressive in Type 1 Diabetes
Effects of GABA(B) receptors in the insula on recognition memory observed with intellicage
Part of Behavioral and Brain Functions, 2017
- DOI for Effects of GABA(B) receptors in the insula on recognition memory observed with intellicage
- Download full text (pdf) of Effects of GABA(B) receptors in the insula on recognition memory observed with intellicage
Part of Neuroscience, p. 300-321, 2017
- DOI for Characterization of the gamma-aminobutyric acid signaling system in the zebrafish (danio rerio hamilton) central nervous system by reverse transcription-quantitative polymerase chain reaction
- Download full text (pdf) of Characterization of the gamma-aminobutyric acid signaling system in the zebrafish (danio rerio hamilton) central nervous system by reverse transcription-quantitative polymerase chain reaction
Part of BMC Pharmacology & Toxicology, 2017
- DOI for Liraglutide modulates GABAergic signaling in rat hippocampal CA3 pyramidal neurons predominantly by presynaptic mechanism
- Download full text (pdf) of Liraglutide modulates GABAergic signaling in rat hippocampal CA3 pyramidal neurons predominantly by presynaptic mechanism
Part of Journal of Neuroimmunology, p. 51-58, 2017
Part of Acta Biomaterialia, p. 211-220, 2016
Part of Diabetes, p. 79-89, 2015
- DOI for GLP-1 and Exendin-4 Transiently Enhance GABA(A) Receptor-Mediated Synaptic and Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons
- Download full text (pdf) of GLP-1 and Exendin-4 Transiently Enhance GABA(A) Receptor-Mediated Synaptic and Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons
Part of Acta Physiologica, p. 575-585, 2015
Part of Acta Physiologica, p. 91-91, 2015
Insulin modulates GABAA receptor-mediated neuronal inhibition in rat hippocampus and amygdala
Part of Acta Physiologica, p. 90-90, 2015
Part of Acta Physiologica, p. 89-90, 2015
Part of PLOS ONE, 2015
- DOI for The GLP-1 Receptor Agonist Exendin-4 and Diazepam Differentially Regulate GABAA Receptor-Mediated Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons
- Download full text (pdf) of The GLP-1 Receptor Agonist Exendin-4 and Diazepam Differentially Regulate GABAA Receptor-Mediated Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons
Part of European Journal of Pharmacology, p. 101-107, 2015
Part of Frontiers in Cellular Neuroscience, p. 11, 2014
Part of Acta Physiologica, p. 83-83, 2014
GABA-A receptor subunit expression in human peripheral blood mononuclear cells
Part of Acta Physiologica, p. 86-86, 2014
Part of Acta Physiologica, p. 100-100, 2014
Part of Frontiers in Cellular Neuroscience, 2014
Insulin modulates GABA(A) receptor-mediated inhibition in rat amygdala neurons
Part of Acta Physiologica, p. 83-83, 2014
Part of Frontiers in Cellular Neuroscience, p. 288, 2014
Part of PLOS ONE, 2013
- DOI for In Intact Islets Interstitial GABA Activates GABA(A) Receptors That Generate Tonic Currents in alpha-Cells
- Download full text (pdf) of In Intact Islets Interstitial GABA Activates GABA(A) Receptors That Generate Tonic Currents in alpha-Cells
GABA is an effective immunomodulatory molecule
Part of Amino Acids, p. 87-94, 2013
Part of Frontiers in Cellular Neuroscience, 2012
- DOI for Selective Changes of GABA(A) Channel Subunit mRNAs in the Hippocampus and Orbitofrontal Cortex but not in Prefrontal Cortex of Human Alcoholics
- Download full text (pdf) of Selective Changes of GABA(A) Channel Subunit mRNAs in the Hippocampus and Orbitofrontal Cortex but not in Prefrontal Cortex of Human Alcoholics
Part of European Journal of Neurology, p. 67-67, 2012
Part of PLOS ONE, 2012
- DOI for GABA-A Channel Subunit Expression in Human Glioma Correlates with Tumor Histology and Clinical Outcome
- Download full text (pdf) of GABA-A Channel Subunit Expression in Human Glioma Correlates with Tumor Histology and Clinical Outcome
Different subtypes of GABA-A receptors are expressed in human, mouse and rat T lymphocytes
Part of PLOS ONE, 2012
- DOI for Different subtypes of GABA-A receptors are expressed in human, mouse and rat T lymphocytes
- Download full text (pdf) of Different subtypes of GABA-A receptors are expressed in human, mouse and rat T lymphocytes
Part of PLoS pathogens, 2012
- DOI for GABAergic Signaling Is Linked to a Hypermigratory Phenotype in Dendritic Cells Infected by Toxoplasma gondii
- Download full text (pdf) of GABAergic Signaling Is Linked to a Hypermigratory Phenotype in Dendritic Cells Infected by Toxoplasma gondii
gamma-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes
Part of Diabetologia, p. 1985-1994, 2012
Part of DNA and Cell Biology, p. 520-523, 2012
Part of Acta Oto-Laryngologica, p. 261-265, 2012
GABA-activated single-channel and tonic currents in rat brain slices
Part of Journal of Visualized Experiments, 2011
Part of Acta Oto-Laryngologica, p. 136-141, 2011
Part of Brain Research, p. 41-49, 2011
Insulin reduces neuronal excitability by turning on GABA(A) channels that generate tonic current
Part of PLOS ONE, 2011
Part of Molecular Immunology, p. 399-407, 2011
Articles, review/survey
GABA signalling in human pancreatic islets
Part of Frontiers in Endocrinology, 2023
- DOI for GABA signalling in human pancreatic islets
- Download full text (pdf) of GABA signalling in human pancreatic islets
All Roads Lead to Rome?: Genes Causing Dravet Syndrome and Dravet Syndrome-Like Phenotypes
Part of Frontiers in Neurology, 2022
- DOI for All Roads Lead to Rome?: Genes Causing Dravet Syndrome and Dravet Syndrome-Like Phenotypes
- Download full text (pdf) of All Roads Lead to Rome?: Genes Causing Dravet Syndrome and Dravet Syndrome-Like Phenotypes
GABAergic signalling in the immune system
Part of Acta Physiologica, p. 819-827, 2015
Chapters in book
GABA is an efficient immunomodulator molecule
Part of Nerve-Driven Immunity, p. 163-173, Springer, 2012