Birgitta Heyman

FcµR and IgM-Mediated Complement Activation Cooperate to Enhance Humoral Immunity

Wen, Zichao; Dong, Lulu; Liu, Jun; Min, Qing et al.

Part of European Journal of Immunology, 2025

• DOI for FcµR and IgM-Mediated Complement Activation Cooperate to Enhance Humoral Immunity

Life‐threatening antibodies: The discovery of anaphylaxis

Daëron, Marc; Heyman, Birgitta; Moulin, Anne Marie

Part of Immunological Reviews, p. 24-38, 2024

• DOI for Life‐threatening antibodies: The discovery of anaphylaxis

Antibody feedback regulation

Heyman, Birgitta

Part of Immunological Reviews, p. 126-142, 2024

• DOI for Antibody feedback regulation
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Antibodies and complement are key drivers of thrombosis

Stark, Konstantin; Kilani, Badr; Stockhausen, Sven; Busse, Johanna et al.

Part of Immunity, p. 2140-21560000000000, 2024

• DOI for Antibodies and complement are key drivers of thrombosis
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Endogenous complement-activating IgM is not required for primary antibody responses but promotes plasma cell differentiation and secondary antibody responses to a large particulate antigen in mice

Palm, Anna-Karin E.; Westin, Annika; Ayranci, Diyar; Heyman, Birgitta

Part of Frontiers in Immunology, 2024

• DOI for Endogenous complement-activating IgM is not required for primary antibody responses but promotes plasma cell differentiation and secondary antibody responses to a large particulate antigen in mice
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FcµR and IgM-Mediated Complement Activation Cooperate to Enhance Humoral Immunity

Wen, Zichao; Dong, Lulu; Liu, Jun; Min, Qing et al.

Part of European Journal of Immunology, 2025

• DOI for FcµR and IgM-Mediated Complement Activation Cooperate to Enhance Humoral Immunity

Antibodies and complement are key drivers of thrombosis

Stark, Konstantin; Kilani, Badr; Stockhausen, Sven; Busse, Johanna et al.

Part of Immunity, p. 2140-21560000000000, 2024

• DOI for Antibodies and complement are key drivers of thrombosis
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Endogenous complement-activating IgM is not required for primary antibody responses but promotes plasma cell differentiation and secondary antibody responses to a large particulate antigen in mice

Palm, Anna-Karin E.; Westin, Annika; Ayranci, Diyar; Heyman, Birgitta

Part of Frontiers in Immunology, 2024

• DOI for Endogenous complement-activating IgM is not required for primary antibody responses but promotes plasma cell differentiation and secondary antibody responses to a large particulate antigen in mice
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A Novel Image Analysis Approach Reveals a Role for Complement Receptors 1 and 2 in Follicular Dendritic Cell Organization in Germinal Centers

Anania, Jessica C.; Westin, Annika; Adler, Jeremy; Heyman, Birgitta

Part of Frontiers in Immunology, 2021

• DOI for A Novel Image Analysis Approach Reveals a Role for Complement Receptors 1 and 2 in Follicular Dendritic Cell Organization in Germinal Centers
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IgG Suppresses Antibody Responses to Sheep Red Blood Cells in Double Knock-Out Mice Lacking Complement Factor C3 and Activating Fc gamma-Receptors

Anania, Jessica; Westin, Annika; Heyman, Birgitta

Part of Frontiers in Immunology, 2020

• DOI for IgG Suppresses Antibody Responses to Sheep Red Blood Cells in Double Knock-Out Mice Lacking Complement Factor C3 and Activating Fc gamma-Receptors
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Cartilage-binding antibodies induce pain through immune complex-mediated activation of neurons

Farinotti, Alex Bersellini; Wigerblad, Gustaf; Nascimento, Diana; Bas, Duygu B. et al.

Part of Journal of Experimental Medicine, p. 1904-1924, 2019

• DOI for Cartilage-binding antibodies induce pain through immune complex-mediated activation of neurons
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IgG-mediated immune suppression in mice is epitope specific except during high epitope density conditions

Xu, Hui; Zhang, Lu; Heyman, Birgitta

Part of Scientific Reports, 2018

• DOI for IgG-mediated immune suppression in mice is epitope specific except during high epitope density conditions
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Epitope-Specific Suppression of IgG Responses by Passively Administered Specific IgG: Evidence of Epitope Masking

Bergström, Joakim; Xu, Hui; Heyman, Birgitta

Part of Frontiers in Immunology, 2017

• DOI for Epitope-Specific Suppression of IgG Responses by Passively Administered Specific IgG: Evidence of Epitope Masking

Mice Immunized With IgG Anti-Sheep Red Blood Cells (SRBC) Together With SRBC Have a Suppressed Anti-SRBC Antibody Response but Generate Germinal Centers and Anti-IgG Antibodies in Response to the Passively Administered IgG

Bergström, Joakim J. E.; Heyman, Birgitta

Part of Frontiers in Immunology, 2017

• DOI for Mice Immunized With IgG Anti-Sheep Red Blood Cells (SRBC) Together With SRBC Have a Suppressed Anti-SRBC Antibody Response but Generate Germinal Centers and Anti-IgG Antibodies in Response to the Passively Administered IgG
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IgG3-antigen complexes are deposited on follicular dendritic cells in the presence of C1q and C3

Zhang, Lu; Ding, Zhoujie; Heyman, Birgitta

Part of Scientific Reports, 2017

• DOI for IgG3-antigen complexes are deposited on follicular dendritic cells in the presence of C1q and C3
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IgM is Unable to Enhance Antibody Responses in Mice Lacking C1q or C3

Sörman, Anna; Westin, Annika; Heyman, Birgitta

Part of Scandinavian Journal of Immunology, p. 381-382, 2017

• DOI for IgM is Unable to Enhance Antibody Responses in Mice Lacking C1q or C3

IgE-mediated enhancement of CD4(+) T cell responses requires antigen presentation by CD8 alpha(-) conventional dendritic cells

Ding, Zhoujie; Dahlin, Joakim S.; Xu, Hui; Heyman, Birgitta

Part of Scientific Reports, 2016

• DOI for IgE-mediated enhancement of CD4(+) T cell responses requires antigen presentation by CD8 alpha(-) conventional dendritic cells
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Enhancement of antibody responses by endogenous (complement activating) IgM

Sörman, Anna Rolfsdotter; Rutemark, Christian; Heyman, Birgitta

Part of Molecular Immunology, p. 185-186, 2015

Antigen Conjugated to Anti-CD23 Antibodies is Rapidly Transported to Splenic Follicles by Recirculating B Cells

Xu, Hui; van Mechelen, Lenny; Henningsson, Frida; Heyman, Birgitta

Part of Scandinavian Journal of Immunology, p. 39-45, 2015

• DOI for Antigen Conjugated to Anti-CD23 Antibodies is Rapidly Transported to Splenic Follicles by Recirculating B Cells

IgG Suppresses Antibody Responses in Mice Lacking C1q, C3, Complement Receptors 1 and 2, or IgG Fc-Receptors.

Bergström, Joakim J E; Heyman, Birgitta

Part of PLOS ONE, 2015

• DOI for IgG Suppresses Antibody Responses in Mice Lacking C1q, C3, Complement Receptors 1 and 2, or IgG Fc-Receptors.
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Marginal-zone B cells transport IgG3-antigen immune complexes into splenic B cell follicles

Zhang, Lu; Ding, Zhoujie; Xu, Hui; Heyman, Birgitta

Part of Molecular Immunology, p. 278-278, 2014

Antigen Transfer from Exosomes to Dendritic Cells as an Explanation for the Immune Enhancement Seen by IgE Immune Complexes

Martin, Rebecca K.; Brooks, Keith B.; Henningsson, Frida; Heyman, Birgitta et al.

Part of PLOS ONE, 2014

• DOI for Antigen Transfer from Exosomes to Dendritic Cells as an Explanation for the Immune Enhancement Seen by IgE Immune Complexes
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Anti-CD23-antigen Conjugates Localize Antigen to Splenic Follicles and Enhance Specific Ab Response

Xu, Hui; Mechelen, Lennyvan; Henningsson, Frida; Heyman, Birgitta

Part of Scandinavian Journal of Immunology, p. 238-238, 2014

Antigen-Specific IgM Causes Deposition of C3 on Sheep Red Blood Cells Within Seconds After Immunization

Bergman, Anna; Ding, Zhoujie; Heyman, Birgitta

Part of Scandinavian Journal of Immunology, p. 442-442, 2014

Enhancement of Antibody Responses by Endogenous IgM

Sörman, Anna; Heyman, Birgitta

Part of Scandinavian Journal of Immunology, p. 234-234, 2014

Divergent Regulation of B and T Cell Responses by Complement-Activating IgM

Ding, Zhoujie; Bergman, Anna; Rutemark, Christian; Ouchida, Rika et al.

Part of Scandinavian Journal of Immunology, p. 442-442, 2014

IgG-mediated Immune Suppression: Discrepancy between Suppression of Antibody and Germinal Center Responses?

Bergström, Joakim J. E.; Xu, Hui; Heyman, Birgitta

Part of Scandinavian Journal of Immunology, p. 210-210, 2014

Marginal Zone B Cells Transport IgG3-Immune Complexes to Splenic Follicles

Zhang, Lu; Ding, Zhoujie; Xu, Hui; Heyman, Birgitta

Part of Journal of Immunology, p. 1681-1689, 2014

• DOI for Marginal Zone B Cells Transport IgG3-Immune Complexes to Splenic Follicles

IgG3-mediated enhancement of antibody responses is dependent on expression of complement receptors 1 and 2

Ding, Zhoujie; Zhang, Lu; Xu, Hui; Heyman, Birgitta

Part of Molecular Immunology, p. 277-278, 2014

The Role of CD23 Expression on Follicular Dendritic Cells in IgE-mediated Enhancement

Ding, Zhoujie; Heyman, Birgitta

Part of Scandinavian Journal of Immunology, p. 215-215, 2014

MZ B Cells Transport IgG3-Ag to Splenic Follicles and Induce Germinal Centers

Zhang, Lu; Ding, Zhoujie; Xu, Hui; Heyman, Birgitta

Part of Scandinavian Journal of Immunology, p. 239-239, 2014

Prospective Isolation of Committed Mast Cell Progenitors from Mouse Blood

Dahlin, Joakim; Heyman, Birgitta; Hallgren, Jenny

Part of Scandinavian Journal of Immunology, p. 436-436, 2014

MZ B Cells Transport IgG3-Ag to Splenic Follicles and Induce Germinal Centres

Zhang, Lu; Ding, Zhoujie; Xu, Hui; Henningsson, Frida et al.

Part of Scandinavian Journal of Immunology, p. 442-443, 2014

IgG-Mediated Suppression of Primary IgG Anti-SRBC Responses is not Dependent on Fc gamma R or Complement

Bergström, Joakim J. E.; Westin, Annika Grahn; Heyman, Birgitta

Part of Scandinavian Journal of Immunology, p. 443-443, 2014

Anti-CD23-Antigen Conjugates Localize Antigen to Splenic Follicles and Enhance Specific Ab Response

Xu, Hui; Mechelen, Lenny; Henningsson, Frida; Heyman, Birgitta

Part of Scandinavian Journal of Immunology, p. 443-443, 2014

B Cell-mediated Antigen Transport to Splenic Follicles

Henningsson, F.; Ding, Zhoujie; Heyman, Birgitta

Part of Scandinavian Journal of Immunology, p. 73-74, 2014

• DOI for B Cell-mediated Antigen Transport to Splenic Follicles

IgE enhances B cell-derived exosomal induced T cell proliferation

Martin, Rebecca; Brooks, Keith; Henningson, Frida; Heyman, Brigitta et al.

Part of Journal of Immunology, 2013

Complement-Activating IgM Enhances the Humoral but Not the T Cell Immune Response in Mice

Ding, Zhoujie; Bergman, Anna; Rutemark, Christian; Ouchida, Rika et al.

Part of PLOS ONE, 2013

• DOI for Complement-Activating IgM Enhances the Humoral but Not the T Cell Immune Response in Mice
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Committed mast cell progenitors in mouse blood differ in maturity between Th1 and Th2 strains

Dahlin, Joakim S; Heyman, Birgitta; Hallgren, Jenny

Part of Allergy. European Journal of Allergy and Clinical Immunology, p. 1333-1337, 2013

• DOI for Committed mast cell progenitors in mouse blood differ in maturity between Th1 and Th2 strains

Identification of committed mast cell progenitors in mouse blood

Dahlin, Joakim S.; Heyman, Birgitta; Hallgren, Jenny Martinsson

Part of Immunology, p. 175-176, 2013

Complement receptors 1 and 2 in murine antibody responses to IgM-complexed and uncomplexed sheep erythrocytes

Rutemark, Christian; Bergman, Anna; Getahun, Andrew; Hallgren, Jenny et al.

Part of PLOS ONE, 2012

• DOI for Complement receptors 1 and 2 in murine antibody responses to IgM-complexed and uncomplexed sheep erythrocytes
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IgM-mediated enhancement of immune responses

Ding, Zhoujie; Bergman, Anna; Rutemark, Christian; Heyman, Birgitta

Part of Immunobiology, p. 1177-1178, 2012

• DOI for IgM-mediated enhancement of immune responses

CD11c(+) Cells Are Required for Antigen-Induced Increase of Mast Cells in the Lung

Dahlin, Joakim S; Feinstein, Ricardo; Cui, Yue; Heyman, Birgitta et al.

Part of Journal of Immunology, p. 3869-3877, 2012

• DOI for CD11c(+) Cells Are Required for Antigen-Induced Increase of Mast Cells in the Lung

Shb deficient mice display an augmented T_H2 response in peripheral CD4+ T cells

Gustafsson, Karin; Calounova, Gabriela; Hjelm, Fredrik; Kriz, Vitezslav et al.

Part of BMC Immunology, p. 3, 2011

• DOI for Shb deficient mice display an augmented T_H2 response in peripheral CD4+ T cells
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IgE Immune Complexes Stimulate an Increase in Lung Mast Cell Progenitors in a Mouse Model of Allergic Airway Inflammation

Dahlin, Joakim S.; Ivarsson, Martin A.; Heyman, Birgitta; Hallgren, Jenny

Part of PLoS One, 2011

• DOI for IgE Immune Complexes Stimulate an Increase in Lung Mast Cell Progenitors in a Mouse Model of Allergic Airway Inflammation

IgE-Mediated Enhancement of CD4(+) T Cell Responses in Mice Requires Antigen Presentation by CD11c(+) Cells and Not by B Cells

Henningsson, Frida; Ding, Zhoujie; Dahlin, Joakim S.; Linkevicius, Marius et al.

Part of PLOS ONE, 2011

• DOI for IgE-Mediated Enhancement of CD4(+) T Cell Responses in Mice Requires Antigen Presentation by CD11c(+) Cells and Not by B Cells
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Requirement for complement in antibody responses is not explained by the classic pathway activator IgM

Rutemark, Christian; Alicot, Elisabeth; Bergman, Anna; Ma, Minghe et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 17589-17590, 2011

• DOI for Requirement for complement in antibody responses is not explained by the classic pathway activator IgM

Complement drives Th17 cell differentiation and triggers autoimmune arthritis

Hashimoto, Motomu; Hirota, Keiji; Yoshitomi, Hiroyuki; Maeda, Shinji et al.

Part of Journal of Experimental Medicine, p. 1135-1143, 2010

• DOI for Complement drives Th17 cell differentiation and triggers autoimmune arthritis

Impaired antibody responses but normal proliferation of CD4+ T cells in mice lacking complement receptors 1 and 2

Carlsson, Fredrik; Getahun, Andrew; Rutemark, Christian; Heyman, Birgitta

Part of Scandinavian Journal of Immunology, p. 77-84, 2009

• DOI for Impaired antibody responses but normal proliferation of CD4+ T cells in mice lacking complement receptors 1 and 2

Studies on the mechanism by which antigen-specific IgG suppresses primary antibody responses: evidence for epitope masking and decreased localization of antigen in the spleen

Getahun, A; Heyman, Birgitta

Part of Scandinavian Journal of Immunology, p. 277-287, 2009

• DOI for Studies on the mechanism by which antigen-specific IgG suppresses primary antibody responses: evidence for epitope masking and decreased localization of antigen in the spleen

A novel B cell-mediated transport of IgE-immune complexes to the follicle of the spleen.

Hjelm, Fredrik; Karlsson, Mikael C. I.; Heyman, Birgitta

Part of Journal of Immunology, p. 6604-6610, 2008

IgE enhances specific antibody and T cell responses in mice overexpressing CD23

Carlsson, Fredrik; Hjelm, Fredrik; Conrad, Daniel H.; Heyman, Birgitta

Part of Scandinavian Journal of Immunology, p. 261-270, 2007

• DOI for IgE enhances specific antibody and T cell responses in mice overexpressing CD23

Antibody-mediated regulation of the immune response

Hjelm, F; Carlsson, F; Getahun, A; Heyman, B

Part of Scandinavian Journal of Immunology, p. 177-184, 2006

• DOI for Antibody-mediated regulation of the immune response

IgG3-mediated enhancement of the antibody response is normal in Fc gammaRI-deficient mice

Hjelm, F; Carlsson, F; Verbeek, S; Heyman, B

Part of Scandinavian Journal of Immunology, p. 453-461, 2005

• DOI for IgG3-mediated enhancement of the antibody response is normal in Fc gammaRI-deficient mice

IgG3-Mediated Enhancement of the Antibody Response is Normal in FcγRI-Deficient Mice

Hjelm, Fredrik; Carlsson, Fredrik; Verbeek, Sjef; Heyman, Birgitta

Part of Scandinavian Journal of Immunology, p. 453-461, 2005

IgG3-mediated enhancement of the antibody response is normal in Fc gammaRI-deficient mice

Hjelm, Fredrik; Carlsson, Fredrik; Verbeek, Sjef; Heyman, Birgitta

Part of Scandinavian Journal of Immunology, p. 453-461, 2005

IgE enhances antibody and T cell responses in vivo via CD23+ B cells

Getahun, Andrew; Hjelm, Fredrik; Heyman, Birgitta

Part of Journal of Immunology, p. 1473-1482, 2005

Antibody feedback inhibition - a biological principle of immune regulation

Heyman, Birgitta

Part of Transfusionmedicine and hematology, p. 348-354, 2005

IgE enhances antibody and T cell responses in vivo via CD23+ B cells.

Getahun, Andrew; Hjelm, Fredrik; Heyman, Birgitta

Part of J Immunol, p. 1473-82, 2005

How antibodies act as natural adjuvants.

Getahun, Andrew; Heyman, Birgitta

Part of Immunol Lett, 2005

IgG2a-mediated enhancement of antibody and T cell responses and its relation to inhibitory and activating Fcγ receptors

Getahun, Andrew; Dahlström, Jörgen; Wernersson, Sara; Heyman, Birgitta

Part of Journal of Immunology, p. 5269-5276, 2004

FcγRIIB in IgG-mediated suppression of antibody responses: Different impact in vivo and in vitro

Karlsson, Mikael C.I.; Getahun, Andrew; Heyman, Birgitta

Part of Journal of Immunology, p. 5558-5564, 2001

Immunoglobulin-secreting cells of maternal origin can be detected in Bcell-deficient mice.

Arvola, M; Gustafsson, E; Svensson, L; Jansson, L et al.

Part of Biol. Reprod., p. 1817, 2000

Importance of CD23 for collagen-induced arthritis: delayed onset and reduced severity in CD23-deficient mice

Kleinau, Sandra; Martinsson, Pernilla; Gustavsson, Susanne; Heyman, Birgitta

Part of Journal of Immunology, p. 4266-4270, 1999

IgG3-Antigen Complexes Are Deposited on Follicular Dendritic Cells in the Presence of C1q and C3

Zhang, Lu; Ding, Zhoujie; Heyman, Birgitta

Part of Scientific Reports

Life‐threatening antibodies: The discovery of anaphylaxis

Daëron, Marc; Heyman, Birgitta; Moulin, Anne Marie

Part of Immunological Reviews, p. 24-38, 2024

• DOI for Life‐threatening antibodies: The discovery of anaphylaxis

Antibody feedback regulation

Heyman, Birgitta

Part of Immunological Reviews, p. 126-142, 2024

• DOI for Antibody feedback regulation
• Download full text (pdf) of Antibody feedback regulation

IgG-mediated suppression of antibody responses: Hiding or snatching epitopes?

Xu, Hui; Heyman, Birgitta

Part of Scandinavian Journal of Immunology, 2020

• DOI for IgG-mediated suppression of antibody responses: Hiding or snatching epitopes?
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How antibodies use complement to regulate antibody responses

Sörman, Anna; Zhang, Lu; Ding, Zhoujie; Heyman, Birgitta

Part of Molecular Immunology, p. 79-88, 2014

• DOI for How antibodies use complement to regulate antibody responses
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Regulation of Humoral Immune Responses and B Cell Tolerance by the IgM Fc Receptor (FcμR)

Liu, Jun; Wang, Ying; Min, Qing; Xiong, Ermeng et al.

Part of B Cells In Immunity And Tolerance, p. 75-86, Springer, 2020

• DOI for Regulation of Humoral Immune Responses and B Cell Tolerance by the IgM Fc Receptor (FcμR)

Specific IgM and Regulation of Antibody Responses

Sörman, Anna; Heyman, Birgitta

Part of IgM and Its Receptors and Binding Proteins, p. 67-87, Springer Berlin/Heidelberg, 2017

• DOI for Specific IgM and Regulation of Antibody Responses

Antibodies as Natural Adjuvants

Heyman, Birgitta

Part of FC RECEPTORS, p. 201-219, 2014

• DOI for Antibodies as Natural Adjuvants

Mice Producing IgM Unable to Activate Complement Have Impaired Endogenous Feedback Regulation but Increased Antigen Trapping in Follicles

Zhang, Lu; Sörman, Anna; Westin, Annika; Heyman, Birgitta

IgE enhances antibody responses and T cell activation in vivo: A central role for B cells

Getahun, Andrew; Hjelm, Fredrik; Heyman, Birgitta

Follicular B cells capture IgE-immune complexes and mediate activation of naïve T cells

Hjelm, Fredrik; Karlsson, Mikael; Heyman, Birgitta