Fredrik Palm
Professor at Department of Medical Cell Biology; Research Group Fredrik Palm
- Telephone:
- +46 18 471 41 82
- E-mail:
- Fredrik.Palm@mcb.uu.se
- Visiting address:
- BMC
Husargatan 3
751 23 Uppsala - Postal address:
- Box 571
751 23 UPPSALA
More information is available to staff who log in.
Publications
Selection of publications
- Activation of Hypoxia-Inducible Factors Prevents Diabetic Nephropathy (2015)
- Differences in susceptibility to develop parameters of diabetic nephropathy in four mouse strains with type 1 diabetes (2014)
- High altitude may alter oxygen availability and renal metabolism in diabetics as measured by hyperpolarized [1-C-13]pyruvate magnetic resonance imaging (2014)
- L-Citrulline, But Not L-Arginine, Prevents Diabetes Mellitus–Induced Glomerular Hyperfiltration and Proteinuria in Rat (2014)
- Inhibition of sodium-linked glucose reabsorption in the kidney normalizes diabetes-induced glomerular hyperfiltration in conscious adenosine A1-receptor-deficient mice (2014)
- Intravoxel Incoherent Motion MR Imaging of the Kidney (2013)
- Increased kidney metabolismas a pathway to kidney tissue hypoxia and damage (2013)
- Kidney Hypoxia, Attributable to Increased Oxygen Consumption, Induces Nephropathy Independently of Hyperglycemia and Oxidative Stress (2013)
- Nitric oxide in afferent arterioles after uninephrectomy depends on extracellular L-arginine (2013)
- Hypoxia in the diabetic kidney is independent of advanced glycation end-products (2013)
- Frontiers in Research Reviews (2013)
- Angiotensin II contributes to glomerular hyperfiltration in diabetic rats independently of adenosine type I receptors (2013)
- Kidney function after in vivo gene silencing of Uncoupling Protein-2 in streptozotocin-induced diabetic rats (2013)
- Adenosine A2 receptor-mediated regulation of renal hemodynamics and glomerular filtration rate is abolished in diabetes (2013)
- Inhibition of hyaluronan synthesis in rats reduces renal ability to excrete fluid and electrolytes during acute hydration (2013)
- Renal oxygenation and function of the rat kidney (2013)
- Simultaneous determination of asymmetric and symmetric dimethylarginine, L-monomethylarginine, L-arginine, and L-homoarginine in biological samples using stable isotope dilution liquid chromatography tandem mass spectrometry (2012)
- Acute knockdown of uncoupling protein-2 increases mitochondria uncoupling via the adenine nucleotide transporter and decreases oxidative stress in diabetic kidneys (2012)
- Coenzyme Q10 prevents GDP-sensitive mitochondrial uncoupling, glomerular hyperfiltration and proteinuria in kidneys from db/db-mice as a model of type 2 diabetes (2012)
- Renomedullary interstitial hyaluronan is important for hydration-induced diuresis (2012)
- The dark side of angiotensin II (2012)
- NADPH oxidase inhibition reduces tubular sodium transport and improves kidney oxygenation in diabetes (2012)
- Insulin induces the correlation between renal blood flow and glomerular filtration rate in diabetes (2012)
- Early transcriptional regulation by C-peptide in freshly isolated rat proximal tubular cells (2011)
- Renoprotective Effects of C-Peptide on Type 1 Diabetes (2011)
- Renal oxidative stress, oxygenation and hypertension (2011)
- The roles of NADPH-oxidase and nNOS for the increased oxidative stress and the oxygen consumption in the diabetic kidney (2010)
- Diabetic nephropathy (2010)
- Role of nitric oxide deficiency in the development of hypertension in hydronephrotic animals (2008)
- Expression of NG,NG-dimethylarginine dimethylaminohydrolase and protein arginine N-methyltransferase isoforms in diabetic rat kidney: effects of angiotensin II receptor blockers (2008)
- Angiotensin II Type 2 Receptors and Nitric Oxide Sustain Oxygenation in the Clipped Kidney of Early Goldblatt Hypertensive Rats (2008)
- Nitric oxide in the kidney (2008)
- Är de nya iso-osmolära röntgenkontrastmedlen mindre njurskadliga jämfört med de låg-osmolära? (2007)
- Commentary on Wilcken et al. Asymmetric Dimethylarginine (ADMA) in Vascular and Renal Disease (2007)
- Dimethylarginine dimethylaminohydrolase (DDAH) (2007)
- Diabetes-induced hyperfiltration in adenosine A(1)-receptor deficient mice lacking the tubuloglomerular feedback mechanism (2007)
- Intrarenal oxygen in diabetes and a possible link to diabetic nephropathy. (2006)
- Diabetes-induced decrease in renal oxygen tension (2006)
- Influence of iothalamate on renal medullary perfusion and oxygenation in the rat. (2005)
- The effects of carbon dioxide versus ioxaglate in the rat kidney. (2005)
- Reduced nitric oxide concentration in the renal cortex of streptozotocin-induced diabetic rats (2005)
- Thick ascending tubular cells in the loop of Henle (2005)
- Promoting islet cell function after transplantation (2004)
- Adenosine A1 receptors in contrast media-induced renal dysfunction in the normal rat. (2004)
- Polyol pathway-dependent disturbances in renal medullary metabolism in experimental insulin-deficient diabetes mellitus in rats (2004)
- Differentiating between effects of streptozotocin per se and subsequent hyperglycemia on renal function and metabolism in the streptozotocin-diabetic rat model (2004)
- pH is decreased in transplanted rat pancreatic islets. (2003)
- Et-A receptor antagonist BQ123 prevents radiocontrast media-induced renalmedullary hypoxia. (2003)
- Effects of the contrast medium iopromide on renal hemodynamics and oxygen tension in the diabetic rat kidney (2003)
- Altered response in renal blood flow and oxygen tension to contrast media in diabetic rats. (2003)
- Reactive oxygen species cause diabetes-induced decrease in renal oxygen tension. (2003)
- Unaltered oxygen tension in rat pancreatic islets despite dissociation of insulin release and islet blood flow. (2002)
- Oxygen tension in isolated transplanted rat islets and in islets of rat whole-pancreas transplants. (2002)
- Low revascularization of experimentally transplanted human pancreatic islets. (2002)
- Markedly decreased oxygen tension in transplanted rat pancreatic islets irrespective of the implantation site. (2001)
- Changing dopaminergic activity through different pathways (2001)
- Glucose-regulated pulsatile insulin release from mouse islets via the K(ATP) channel-independent pathway. (2001)
- Engraftment and growth of transplanted pancreatic islets. (2000)
Recent publications
- Renal mitochondrial dysfunction in ovine experimental sepsis-associated acute kidney injury (2023)
- Adenosine reuptake inhibition reduces diabetes-induced glomerular hyperfiltration via the adenosine A2a receptor (2023)
- Dose-dependent regulation of kidney mitochondrial function by angiotensin II (2023)
- AST-120 to Target Protein-Bound Uremic Toxins Improves Cardiac Output and Kidney Oxygenation in Experimental Chronic Kidney Disease (2023)
- Decreased renal perfusion during acute kidney injury in critical COVID-19 assessed by magnetic resonance imaging (2022)
All publications
Articles
- Renal mitochondrial dysfunction in ovine experimental sepsis-associated acute kidney injury (2023)
- Adenosine reuptake inhibition reduces diabetes-induced glomerular hyperfiltration via the adenosine A2a receptor (2023)
- Dose-dependent regulation of kidney mitochondrial function by angiotensin II (2023)
- AST-120 to Target Protein-Bound Uremic Toxins Improves Cardiac Output and Kidney Oxygenation in Experimental Chronic Kidney Disease (2023)
- Decreased renal perfusion during acute kidney injury in critical COVID-19 assessed by magnetic resonance imaging (2022)
- Mitochondrial Respiration-Dependent ANT2-UCP2 Interaction (2022)
- Thyroid hormone increases oxygen metabolism causing intrarenal tissue hypoxia; a pathway to kidney disease (2022)
- Repression of hypoxia-inducible factor-1 contributes to increased mitochondrial reactive oxygen species production in diabetes (2022)
- Pharmacological HIF-PHD inhibition reduces renovascular resistance and increases glomerular filtration by stimulating nitric oxide generation (2021)
- Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK (2021)
- Circadian variation in renal blood flow and kidney function in healthy volunteers monitored with noninvasive magnetic resonance imaging (2020)
- A model of mitochondrial O-2 consumption and ATP generation in rat proximal tubule cells (2020)
- Intrarenal oxygenation determines kidney function during the recovery from an ischemic insult (2020)
- Determinants of renal oxygen metabolism during low Na+ diet (2020)
- Erik Persson (1941-2020) (2020)
- Metabolite aberrations in early diabetes detected in rat kidney using mass spectrometry imaging (2019)
- Metformin attenuates renal medullary hypoxia in diabetic nephropathy through inhibition uncoupling protein-2 (2019)
- Multiparametric assessment of renal physiology in healthy volunteers using noninvasive magnetic resonance imaging (2019)
- High Intrarenal Lactate Production Inhibits the Renal Pseudohypoxic Response to Acutely Induced Hypoxia in Diabetes (2019)
- Role of carbonic anhydrase in acute recovery following renal ischemia reperfusion injury (2019)
- Acute intrarenal angiotensin (1-7) infusion decreases diabetes-induced glomerular hyperfiltration but increases kidney oxygen consumption in the rat (2019)
- Intrarenal activation of endothelin type B receptors improves kidney oxygenation in type 1 diabetic rats (2018)
- Deletion of Uncoupling Protein-2 reduces renal mitochondrial leak respiration, intrarenal hypoxia and proteinuria in a mouse model of type 1 diabetes (2018)
- Editorial (2018)
- Acute renal metabolic effect of metformin assessed with hyperpolarised MRI in rats (2018)
- The effect of inactin on kidney mitochondrial function and production of reactive oxygen species (2018)
- Inhibition of mammalian target of rapamycin decreases intrarenal oxygen availability and alters glomerular permeability (2018)
- Metformin Normalises Medullary Hypoxia in The Diabetic Rat Kidney (2017)
- Ex vivo hyperpolarized MR spectroscopy on isolated renal tubular cells (2017)
- Antioxidant treatment attenuates lactate production in diabetic nephropathy (2017)
- Role of carbonic anhydrase in acute recovery following renal ischemia reperfusion injury (2017)
- 15-Deoxy-Delta(12,14)-prostaglandin J(2) Exerts Antioxidant Effects While Exacerbating Inflammation in Mice Subjected to Ureteral Obstruction (2017)
- Cellular transport of L-Arginine determines renal medullary blood flow in control rats, but not in diabetic rats despite enhanced cellular uptake capacity (2017)
- Hypoxia-inducible factor activation in diabetic kidney disease. (2017)
- Hyaluronan Production by Renomedullary Interstitial Cells (2017)
- Pronounced kidney hypoxia precedes albuminuria in type 1 diabetic mice (2016)
- Pancreatic islet blood flow and its measurement (2016)
- Combining sodium-dependent glucose co-transporter 2 inhibition with conventional diuretics (2016)
- Iodinated contrast media inhibit oxygen consumption in freshly isolated proximal tubular cells from elderly humans and diabetic rats (2016)
- Renal oxygenation during haemorrhage is not aggravated by angiotensin II AT1-receptor blockade (2016)
- The use of hydrogen gas clearance for blood flow measurements in single endogenous and transplanted pancreatic islets (2015)
- Endothelin type A receptor inhibition normalises intrarenal hypoxia in rats used as a model of type 1 diabetes by improving oxygen delivery (2015)
- A role for the extracellular matrix component hyaluronan in kidney dysfunction during ACE-inhibitor fetopathy (2015)
- Angiotensin II AT1-receptor blockade using Losartan does not impair renal oxygenation following hemorrhage (2015)
- Activation of Hypoxia-Inducible Factors Prevents Diabetic Nephropathy (2015)
- Acute SGLT inhibition normalizes O-2 tension in the renal cortex but causes hypoxia in the renal medulla in anaesthetized control and diabetic rats (2015)
- ET-1 increases reactive oxygen species in hypoxic glomeruli during high salt intake (2015)
- Intrarenal Blockade of Angiotensin II AT(1) Receptor Abolishes Renal Cortical Hypoxia in Salt Restricted Animals (2015)
- Adenosine A2 a receptor stimulation prevents proteinuria in diabetic rats by promoting an anti-inflammatory phenotype without affecting oxidative stress (2015)
- Reduced adenosine A2a receptor–mediated efferent arteriolar vasodilation contributes to diabetes-induced glomerular hyperfiltration (2015)
- Inhibition of mTOR activity in diabetes mellitus reduces proteinuria but not renal accumulation of hyaluronan (2015)
- Endothelin receptor A blockade normalizes kidney tissue hypoxia in type-1 diabetic rats (2014)
- Differences in susceptibility to develop parameters of diabetic nephropathy in four mouse strains with type 1 diabetes (2014)
- Repetitive Measurements of Intrarenal Oxygenation In Vivo Using L Band Electron Paramagnetic Resonance (2014)
- Renal hypoxia due to increased oxygen metabolism is an independent pathway to nephropathy (2014)
- Angiotensin II Reduces Transport-Dependent Oxygen Consumption but Increases Transport-Independent Oxygen Consumption in Immortalized Mouse Proximal Tubular Cells (2014)
- Insufficient insulin administration to diabetic rats increases substrate utilization and maintains lactate production in the kidney (2014)
- High altitude may alter oxygen availability and renal metabolism in diabetics as measured by hyperpolarized [1-C-13]pyruvate magnetic resonance imaging (2014)
- Hyperpolarized C-13 MRS reveals hypoxia accelerates pseudo hypoxia in the diabetic kidney (2014)
- Renal oxygen metabolism in animals feed a low salt diet (2014)
- L-citrulline, but not L-arginine, prevents diabetes-induced glomerular hyperfiltration and proteinuria (2014)
- L-Citrulline, But Not L-Arginine, Prevents Diabetes Mellitus–Induced Glomerular Hyperfiltration and Proteinuria in Rat (2014)
- Pre-existing hypoxia sensitizes the kidney to an ischemia-reperfusion insult (2014)
- Inhibition of sodium-linked glucose reabsorption in the kidney normalizes diabetes-induced glomerular hyperfiltration in conscious adenosine A1-receptor-deficient mice (2014)
- Effects of hypertension, diabetes mellitus, obesity and other factors on kidney haemodynamics. (2014)
- Intravoxel Incoherent Motion MR Imaging of the Kidney (2013)
- Increased kidney metabolismas a pathway to kidney tissue hypoxia and damage (2013)
- Kidney Hypoxia, Attributable to Increased Oxygen Consumption, Induces Nephropathy Independently of Hyperglycemia and Oxidative Stress (2013)
- Determinants of kidney oxygen consumption and their relationship to tissue oxygen tension in diabetes and hypertension (2013)
- Nitric oxide in afferent arterioles after uninephrectomy depends on extracellular L-arginine (2013)
- Hypoxia in the diabetic kidney is independent of advanced glycation end-products (2013)
- Frontiers in Research Reviews (2013)
- Angiotensin II contributes to glomerular hyperfiltration in diabetic rats independently of adenosine type I receptors (2013)
- Kidney function after in vivo gene silencing of Uncoupling Protein-2 in streptozotocin-induced diabetic rats (2013)
- Adenosine A2 receptor-mediated regulation of renal hemodynamics and glomerular filtration rate is abolished in diabetes (2013)
- Metabolic changes in summer active and anuric hibernating free-ranging brown bears (Ursus arctos). (2013)
- Inhibition of hyaluronan synthesis in rats reduces renal ability to excrete fluid and electrolytes during acute hydration (2013)
- Renal oxygenation and function of the rat kidney (2013)
- Simultaneous determination of asymmetric and symmetric dimethylarginine, L-monomethylarginine, L-arginine, and L-homoarginine in biological samples using stable isotope dilution liquid chromatography tandem mass spectrometry (2012)
- Acute knockdown of uncoupling protein-2 increases mitochondria uncoupling via the adenine nucleotide transporter and decreases oxidative stress in diabetic kidneys (2012)
- Coenzyme Q10 prevents GDP-sensitive mitochondrial uncoupling, glomerular hyperfiltration and proteinuria in kidneys from db/db-mice as a model of type 2 diabetes (2012)
- Renomedullary interstitial hyaluronan is important for hydration-induced diuresis (2012)
- Effects of the antioxidant drug tempol on renal oxygenation in mice with reduced renal mass. (2012)
- The dark side of angiotensin II (2012)
- NADPH oxidase inhibition reduces tubular sodium transport and improves kidney oxygenation in diabetes (2012)
- Insulin induces the correlation between renal blood flow and glomerular filtration rate in diabetes (2012)
- Renal interstitial hyaluronan (2012)
- Early transcriptional regulation by C-peptide in freshly isolated rat proximal tubular cells (2011)
- Renal oxidative stress, oxygenation and hypertension (2011)
- Renal tubulointerstitial hypoxia (2011)
- Angiotensin converting enzyme inhibition blocks interstitial hyaluronan dissipation in the neonatal rat kidney via hyaluronan synthase 2 and hyaluronidase 1 (2011)
- The roles of NADPH-oxidase and nNOS for the increased oxidative stress and the oxygen consumption in the diabetic kidney (2010)
- Modulation of Shigella virulence in response to available oxygen in vivo (2010)
- Nitric oxide originating from NOS1 controls oxygen utilization and electrolyte transport efficiency in the diabetic kidney (2010)
- Uremia induces abnormal oxygen consumption in tubules and aggravates chronic hypoxia of the kidney via oxidative stress (2010)
- Blood pressure, blood flow, and oxygenation in the clipped kidney of chronic 2-kidney, 1-clip rats (2010)
- Tubular reabsorption and diabetes-induced glomerular hyperfiltration (2010)
- Reduced oxygenation in diabetic rat kidneys measured by T2* weighted magnetic resonance micro-imaging (2009)
- Diabetes, oxidative stress, nitric oxide and mitochondria function (2009)
- Identification and distribution of uncoupling protein isoforms in the normal and diabetic rat kidney (2009)
- Angiotensin II-induced contraction is attenuated by nitric oxide in afferent arterioles from the nonclipped kidney in 2K1C (2009)
- Iodinated contrast media decrease renomedullary blood flow. A possible cause of contrast media-induced nephropathy (2009)
- Proinsulin C-peptide reduces diabetes-induced glomerular hyperfiltration via efferent arteriole dilation and inhibition of tubular sodium reabsorption (2009)
- Nitric oxide and kidney oxygenation (2009)
- Cellular ADMA (2009)
- Role of nitric oxide deficiency in the development of hypertension in hydronephrotic animals (2008)
- Diabetes-induced up-regulation of uncoupling protein-2 results in increased mitochondrial uncoupling in kidney proximal tubular cells (2008)
- Bacterial infection-mediated mucosal signalling induces local renal ischaemia as a defence against sepsis (2008)
- Renal and vascular benefits of C-peptide (2008)
- Expression of NG,NG-dimethylarginine dimethylaminohydrolase and protein arginine N-methyltransferase isoforms in diabetic rat kidney: effects of angiotensin II receptor blockers (2008)
- Angiotensin II Type 2 Receptors and Nitric Oxide Sustain Oxygenation in the Clipped Kidney of Early Goldblatt Hypertensive Rats (2008)
- Reduced nitric oxide in diabetic kidneys due to increased hepatic arginine metabolism (2008)
- Nitric oxide in the kidney (2008)
- Är de nya iso-osmolära röntgenkontrastmedlen mindre njurskadliga jämfört med de låg-osmolära? (2007)
- Diabetes-induced alterations in renal medullary microcirculation and metabolism (2007)
- Commentary on Wilcken et al. Asymmetric Dimethylarginine (ADMA) in Vascular and Renal Disease (2007)
- Dimethylarginine dimethylaminohydrolase (DDAH) (2007)
- Diabetes-induced hyperfiltration in adenosine A(1)-receptor deficient mice lacking the tubuloglomerular feedback mechanism (2007)
- Intrarenal oxygen in diabetes and a possible link to diabetic nephropathy. (2006)
- Diabetes-induced decrease in renal oxygen tension (2006)
- Influence of iothalamate on renal medullary perfusion and oxygenation in the rat. (2005)
- The effects of carbon dioxide versus ioxaglate in the rat kidney. (2005)
- Reduced nitric oxide concentration in the renal cortex of streptozotocin-induced diabetic rats (2005)
- Thick ascending tubular cells in the loop of Henle (2005)
- Promoting islet cell function after transplantation (2004)
- Adenosine A1 receptors in contrast media-induced renal dysfunction in the normal rat. (2004)
- Polyol pathway-dependent disturbances in renal medullary metabolism in experimental insulin-deficient diabetes mellitus in rats (2004)
- Differentiating between effects of streptozotocin per se and subsequent hyperglycemia on renal function and metabolism in the streptozotocin-diabetic rat model (2004)
- pH is decreased in transplanted rat pancreatic islets. (2003)
- Et-A receptor antagonist BQ123 prevents radiocontrast media-induced renalmedullary hypoxia. (2003)
- Effects of the contrast medium iopromide on renal hemodynamics and oxygen tension in the diabetic rat kidney (2003)
- Altered response in renal blood flow and oxygen tension to contrast media in diabetic rats. (2003)
- Reactive oxygen species cause diabetes-induced decrease in renal oxygen tension. (2003)
- Unaltered oxygen tension in rat pancreatic islets despite dissociation of insulin release and islet blood flow. (2002)
- Oxygen tension in isolated transplanted rat islets and in islets of rat whole-pancreas transplants. (2002)
- Low revascularization of experimentally transplanted human pancreatic islets. (2002)
- Markedly decreased oxygen tension in transplanted rat pancreatic islets irrespective of the implantation site. (2001)
- Changing dopaminergic activity through different pathways (2001)
- Glucose-regulated pulsatile insulin release from mouse islets via the K(ATP) channel-independent pathway. (2001)
- Engraftment and growth of transplanted pancreatic islets. (2000)
- Chronically decreased oxygen tension in rat pancreatic islets transplantedunder the kidney capsule (2000)
- Uncoupling protein 2 mediates age-related mitochondria inefficiency and urinary protein excretion
- Hypoxia-inducible factors activation protects mitochondria function and prevents albuminuria in kidney-specific diabetic von Hippel-Lindau deficient mice
- Activation of hypoxia inducible factor due to reduced prolyl hydroxylase 2 activity prevents renal mitochondria dysfunction and improves cortical oxygenation in type 1 diabetic mice
- Attempts to develop a cell-based assay for Diabetic Kidney Disease
- Plasma expansion and renal perfusion in critical COVID-19 with AKI: a prospective case control study
- OR-1896, an active metabolite of levosimendan, ameliorates hemorrhage-associated acute kidney injury by maintaining renal oxygenation
- Tissue Specific Binding of Radiolabelled C-Peptide in Healthy and Diabetic Rats
- NKCC2 inhibition reduces renal blood flow and glomerular filtration ratein diabetic and control rats; impact of hydrostatic pressures maintained byintact renal capsule
- Dose-dependent angiotensin II regulation of mitochondrial function – involvement of Uncoupling protein and Adenine nucleotide translocator
- Lowering plasma levels of protein-bound uremic toxins improves cardiac output and renal oxygenation in a rat model of chronic kidney disease
- Thyroid hormone increases oxygen metabolism causing intrarenal tissue hypoxia; a pathway to kidney disease