Ewert Bengtsson
Professor emeritus at Department of Information Technology; Vi3; Image Analysis
- E-mail:
- ewert.bengtsson@it.uu.se
- Visiting address:
- Hus 10, Regementsvägen 10
- Postal address:
- Box 337
751 05 UPPSALA
- CV:
- Download CV
Short presentation
Ewert Bengtsson is professor emeritus of computerized image analysis with a research focus on biomedical applications. He has been active in the establishment of this subject at Uppsala University since 1973 and the creation of the Centre for Image Analysis, CBA in 1988. He has since then been involved in the development of CBA to become a leading research centre. His research is currently focused on the development of an AI based systems for aggressiveness grading of prostate cancer.
Keywords
- bildanalys
- image analysis
- biomedical image analysis
- image processing
- medical image analysis
- image cytometry
- prostate cancer aggressiveness grading
Biography
My main research interest is in developing computerized image analysis for medical applications. I have been working in that field since my Master Thesis work in 1973-74. That work was dealing with Analysis of cell images using video and computer technology. My doctoral thesis in 1977 was dealing with the same subject. I have since then supervised 15 doctoral theses in that field. My most recently supervised PhD on that topic, Patrik Malm, worked on developing computerized analysis of PAP-smears for early detection of cervical cancer, the same problem as I was addressing in my PhD thesis some 50 years ago. My early research resulted in a working, but far from cost-effective, solution. Since then commercial systems have appeared on the market but they are also very expensive and only used in rich countries. My most recent work on that topic was to be involved in developing a new generation system, cost effective enough to be used in countries such as India where the main part of the project took place. It lead to a product that has been commercialized by an Indian company.
A former PhD student of mine, professor Joakim Lindblad is continuing this line of working and is now focusing on applying it to oral cancer which from an image analysis point of view has many similarities to cervical cancer.
Most of the work has been related to cancer research but our research has also found applications in solving cell biology problems. Digital imaging cytometry is a field of rapidly growing importance. One of my former PhD students, Carolina Wählby, is now professor of Quantitative Microscopy and is very successfully leading this research in close collaboration with the Science for Life Laboratory project.
But cell image analysis is not my only interest. I have also worked with other medical images e.g. from radiology (CT, MR) or nuclear medicine (PET, SPECT). We have also had a project on using haptic interaction to supplement the visual one in exploring medical images in particular for planning of maxillofacial surgery. Professor Ingela Nyström is continuing work on that project as well as other visualization projects.
Our research at CBA also covers many other things. The first full professor in image analysis at the centre, starting 1993, was Gunilla Borgefors. She is well established in the field of digital geometry where she has made several fundamental contributions. Those methods are used in many of our applied projects both by her students and mine. One of her former students, Robin Strand is currently head of the IT-department. He and Filip Malmberg are working in close collaboration with the Radiology Department at Uppsala University developing fundamental medical image analysis algorithms.
We also have research on several other image analysis application fields, computer graphics and visualization headed by another of my former PhD students, professor Anders Hast.
For a much more complete account of my research over the years I refer to the other web-pages at www.cb.uu.se e.g. the personal web-pages of my colleagues and students and in particular to our annual reports which each year listed all our ongoing projects, publications, collaboration partners and other activities up until 2021.
After my retirement I took the initiative of creating a spin-off company together with professor emeritus Christer Busch whom I have collaborated with since the early 1990-ies on image analysis applications to uropathology. The goal of the company is to create an AI and image analysis based way of objectively grading prostate cancer aggressiveness. Our special approach is to train our system on patient disease outcome, not on subjective ground truth. The results are promising, we outperform previously published prostate cancer grading results.

Publications
Recent publications
-
Part of Medical Image Analysis, 2026
- DOI for A systematic analysis of the impact of data variation on AI-based histopathological grading of prostate cancer
- Download full text (pdf) of A systematic analysis of the impact of data variation on AI-based histopathological grading of prostate cancer
-
Robust, credible, and interpretable AI-based histopathological prostate cancer grading
Part of medRxiv, 2024
- DOI for Robust, credible, and interpretable AI-based histopathological prostate cancer grading
- Download full text (pdf) of Robust, credible, and interpretable AI-based histopathological prostate cancer grading
-
Part of Medical Research Archives, 2023
- DOI for Difficulties and Recommendations for AI-Based Prediction of Prostate Cancer Aggressiveness in Digital Pathology
- Download full text (pdf) of Difficulties and Recommendations for AI-Based Prediction of Prostate Cancer Aggressiveness in Digital Pathology
-
Part of Journal of Pathology Informatics, 2022
- DOI for AI based prostate analysis system trained without human supervision to predict patient outcome from tissue samples
- Download full text (pdf) of AI based prostate analysis system trained without human supervision to predict patient outcome from tissue samples
-
Special Section on Image Cytometry
Part of Cytometry Part A, p. 363-365, 2019
All publications
Articles in journal
-
Part of Medical Image Analysis, 2026
- DOI for A systematic analysis of the impact of data variation on AI-based histopathological grading of prostate cancer
- Download full text (pdf) of A systematic analysis of the impact of data variation on AI-based histopathological grading of prostate cancer
-
Robust, credible, and interpretable AI-based histopathological prostate cancer grading
Part of medRxiv, 2024
- DOI for Robust, credible, and interpretable AI-based histopathological prostate cancer grading
- Download full text (pdf) of Robust, credible, and interpretable AI-based histopathological prostate cancer grading
-
Part of Journal of Pathology Informatics, 2022
- DOI for AI based prostate analysis system trained without human supervision to predict patient outcome from tissue samples
- Download full text (pdf) of AI based prostate analysis system trained without human supervision to predict patient outcome from tissue samples
-
Special Section on Image Cytometry
Part of Cytometry Part A, p. 363-365, 2019
-
Part of Cytometry Part A, p. 714-716, 2019
-
Part of Journal of Medical Imaging, 2017
-
Computer-aided diagnostics in digital pathology
Part of Cytometry Part A, p. 551-554, 2017
-
Fast vascular skeleton extraction algorithm
Part of Pattern Recognition Letters, p. 67-75, 2016
-
Part of International Journal of Computer Mathematics, p. 1241-1253, 2016
-
Computer Assisted Pap Smear Analyser for Cervical Cancer Screening using Quantitative Microscopy
Part of Journal of Cytology & Histology, 2015
-
Simulation of bright-field microscopy images depicting pap-smear specimen
Part of Cytometry Part A, p. 212-226, 2015
- DOI for Simulation of bright-field microscopy images depicting pap-smear specimen
- Download full text (pdf) of Simulation of bright-field microscopy images depicting pap-smear specimen
-
Part of Computer Methods and Programs in Biomedicine, p. 49-64, 2015
-
Automated Classification of Glandular Tissue by Statistical Proximity Sampling
Part of International Journal of Biomedical Imaging, 2015
- DOI for Automated Classification of Glandular Tissue by Statistical Proximity Sampling
- Download full text (pdf) of Automated Classification of Glandular Tissue by Statistical Proximity Sampling
-
Automated classification of glandular tissue by statistical proximity sampling.
Part of International Journal of Biomedical Imaging, 2015
-
3D Texture Analysis in Renal Cell Carcinoma Tissue Image Grading
Part of Computational & Mathematical Methods in Medicine, 2014
- DOI for 3D Texture Analysis in Renal Cell Carcinoma Tissue Image Grading
- Download full text (pdf) of 3D Texture Analysis in Renal Cell Carcinoma Tissue Image Grading
-
Image segmentation and identification of paired antibodies in breast tissue
Part of Computational & Mathematical Methods in Medicine, 2014
- DOI for Image segmentation and identification of paired antibodies in breast tissue
- Download full text (pdf) of Image segmentation and identification of paired antibodies in breast tissue
-
Blind Color Decomposition of Histological Images
Part of IEEE Transactions on Medical Imaging, p. 983-994, 2013
-
Debris removal in Pap-smear images
Part of Computer Methods and Programs in Biomedicine, p. 128-138, 2013
-
Part of Signal Processing, p. 2828-2837, 2013
-
Part of International Journal of Imaging and Robotics, p. 61-72, 2013
-
Part of Journal of Nuclear Medicine Technology, p. 27-34, 2011
-
Part of Aging Cell, p. 685-697, 2010
-
Part of Reproductive Toxicology, p. 156-163, 2010
-
Part of Journal of Nuclear Medicine Technology, p. 53-60, 2010
-
Part of Experimental Physiology, p. 117-129, 2009
-
Part of Neuromuscular Disorders, p. 605-606, 2009
-
Part of Neuromuscular Disorders, p. 605-606, 2009
-
Part of The Open Neuroimaging Journal, p. 1-16, 2009
- DOI for Performance of Principal Component Analysis and Independent Component Analysis with Respect to Signal Extraction from Noisy Positron Emission Tomography Data: a Study on Computer Simulated Images
- Download full text (pdf) of Performance of Principal Component Analysis and Independent Component Analysis with Respect to Signal Extraction from Noisy Positron Emission Tomography Data: a Study on Computer Simulated Images
-
Fully Automatic Heart Beat Rate Determination in Digital Video Recordings of Rat Embryos
Part of Transactions on Mass-Data Analysis of Images and Signals, p. 132-146, 2009
-
Vectorized table driven algorithms for double precision elementary functions using taylor expansions
Part of Aplimat: journal of applied mathematics, p. 171-187, 2009
-
Finding cells, finding molecules, finding patterns
Part of International Journal of Signal and Imaging Systems Engineering, p. 11-17, 2008
-
Part of Biophysical Journal, 2007
-
Application of underwater hyperspectral data for color correction purposes
Part of Pattern Recognition and Image Analysis, p. 170-173, 2007
-
Part of IEEE Transactions on Nuclear Science, p. 2759-2768, 2006
-
Part of NeuroImage, p. 588-598, 2006
-
Part of Bio Medical Central (BMC): Medical Imaging, 2005
-
Part of Bio Medical Central (BMC): Medical Imaging, 2005
-
Part of Journal of Microscopy, p. 67-76, 2004
-
Image Analysis for Automatic Segmentation of Cytoplasms and Classification of Rac1 Activation
Part of Cytometry, p. 22-23, 2004
-
Robust cell image segmentation methods
Part of Pattern Recognition and Image Analysis: Advances in Mathematical Theory and Applications, p. 157-167, 2004
-
Abnormal expression pattern of cyclin E in tumour cells
Part of International Journal of Cancer, p. 369-375, 2003
-
A feature set for cytometry on digitized microscopic images
Part of Analytical Cellular Pathology, p. 1-36, 2003
-
Part of Cytometry, p. 32-41, 2002
-
Automatic registration and error detection of multiple slices using landmarks
Part of Analytical Cellular Pathology, p. 159-165, 2001
-
A detailed analysis of cyclin A accumulation at the G1/S border in normal and transformed cells
Part of Experimental Cell Research, p. 86-95, 2000
-
Part of Urology, p. 192-198, 1999
-
Part of Urology, p. 862-868, 1999
-
Modeling prostate cancer distributions
Part of Urology, p. 1028-1034, 1999
-
Part of Analytical Cellular Pathology, p. 111-23, 1998
-
A Computer Program for Logistic Prediction Modelling
Part of Computer Programs in Biomedicine, p. 235-238, 1985
-
Cardiac Glycosides and Breast Cancer Revised: Letter to the Editor
Part of New England Journal of Medicine, p. 484, 1982
-
Predicting Breast Cancer Recurrence
Part of Cancer, p. 2884-2893, 1982
Articles, review/survey
-
Part of Medical Research Archives, 2023
- DOI for Difficulties and Recommendations for AI-Based Prediction of Prostate Cancer Aggressiveness in Digital Pathology
- Download full text (pdf) of Difficulties and Recommendations for AI-Based Prediction of Prostate Cancer Aggressiveness in Digital Pathology
-
Screening for Cervical Cancer Using Automated Analysis of PAP-Smears
Part of Computational & Mathematical Methods in Medicine, 2014
- DOI for Screening for Cervical Cancer Using Automated Analysis of PAP-Smears
- Download full text (pdf) of Screening for Cervical Cancer Using Automated Analysis of PAP-Smears
Chapters in book
-
Rapid prototyping of image analysis applications
Part of Medical Image Processing, p. 5-25, Springer, 2011
-
An alternative model for shading of diffuse light for rough materials
Part of Game Programming Gems 7, p. 373-380, Charles River Media, 2008
-
Part of Game programming Gems 7, p. 191-198, Charles River Media, 2008
-
Minimal Acceleration Hermite Curves
Part of Game Programming Gems 5, p. 225-231, Charles River Media, Hingham, Massachusetts, 2005
-
A modified Phong-Blinn light model for shadowed areas
Part of Graphics programming methods, p. 231-235, Charles River Media, 2003
Collections (editor)
-
Centre for Image Analysis Annual Report 2009
Uppsala University Printers, 2010
-
2009
-
IT i skolan mellan vision och praktik: en forskningsöversikt
Skolverket, 2000
Conference papers
-
Part of 3rd NEUBIAS Conference, Luxembourg, 2-8 February 2019, 2019
-
Part of CYTO2018, 2018
-
Part of EAOM2018, 2018
-
Part of Medical Image Understanding and Analysis, p. 182-194, 2017
-
Deep convolutional neural networks for detecting cellular changes due to malignancy
Part of Proc. 16th International Conference on Computer Vision Workshops, p. 82-89, 2017
-
Image processing and its hardware support: Analysis vs synthesis - historical trends
Part of Image Analysis, SCIA 2017, Pt I, p. 3-14, 2017
-
Automatic grading of breast cancer from whole slide images of Ki67 stained tissue sections
2016
-
Microscopy image enhancement for cost-effective cervical cancer screening
Part of Image Analysis, p. 440-451, 2015
-
Quantitative and automated microscopy: Where do we stand after 80 years of research?
Part of Proc. 11th International Symposium on Biomedical Imaging, p. 274-277, 2014
-
Optimizing optics and imaging for pattern recognition based screening tasks
Part of Proc. 22nd International Conference on Pattern Recognition, p. 3333-3338, 2014
-
Part of Proc. 22nd International Conference on Pattern Recognition, p. 1189-1193, 2014
-
Cluster detection and field-of-view quality rating: Applied to automated Pap-smear analysis
Part of Proc. 2nd International Conference on Pattern Recognition Applications and Methods, p. 355-364, 2013
-
An Algorithm for Parallel Calculation of Trigonometric and Exponential Functions
Part of ACM International Conference on Computing Frontiers, 2013
-
Part of Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, p. 5372-5375, 2012
-
An Investigation on Nuclei of Histopathological Images using Curvelet Statistical Features
2012
-
Cluster detection in cytology images using the cellgraph method
Part of Information Technology in Medicine and Education (ITME), 2012 International Symposium, p. 923-927, 2012
-
Smart Paint: A New Interactive Segmentation Method\\ Applied to MR Prostate Segmentation
Part of Prostate MR Image Segmentation Grand Challenge (PROMISE'12), a MICCAI 2012 workshop, 2012
-
The CerviSCAN project: Project description and current progress
Part of Proceedings SSBA 2011, 2011
-
Part of International Conference on Computational Intelligence and Computing Research (ICCIC), 2010 IEEE, p. 1-6, 2010
-
Part of Proceedings 2010 International Conference on Digital Image Computing: Techniques and Applications (DICTA 2010), p. 611-616, 2010
-
PAPSYNTH: Simulated Bright-field Images of Cervical Smears
Part of 2010 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, 2010
-
Relaxed Image Foresting Transforms for Interactive Volume Image Segmentation
Part of MEDICAL IMAGING 2010, 2010
-
Image-based comparison of pre-modern coins and medals
Part of 16 Workshop Farbbildverarbeitung, p. 156-169, 2010
-
Part of 9th International ELMI Meeting on Advanced Light Microscopy, p. 66-67, 2009
-
Dimensionality Reduction for Colour Based Pixel Classification
Part of Proceedings SSBA 2009, p. 65-68, 2009
-
Segmentation and Visualization of 3D Medical Images through Haptic Rendering
Part of Proceedings of the 10th International Conference on Pattern Recognition and Information Processing (PRIP 2009), p. 43-48, 2009
-
Vectorized table driven algorithms for double precision elementary functions using Taylor expansions
2009
-
Vectorized table driven algorithms for double precision elementary functions using Taylor expansions
2009
-
Fully Automatic Heart Beat Rate Determination in Digital Video Recordings of Rat Embryos
Part of ADVANCES IN MASS DATA ANALYSIS OF IMAGES AND SIGNALS IN MEDICINE, BIOTECHNOLOGY, CHEMISTRY AND FOOD INDUSTRY, PRCEEDINGS, p. 27-37, 2008
-
Measuring Heart Rate from Rat Embryo Videos
Part of Swedish Symposium on Image Analysis, p. 35-38, 2008
-
Algorithms for cross-talk suppression in fluorescence microscopy
Part of Medicinteknikdagarna 2008, p. 64-64, 2008
-
Analysis of Skeletal Fibers in Three Dimensional Images: Methodological considerations
Part of XXXVIth European Muscle Conference of the European Society for Muscle Research, p. 130, 2007
-
Analysis of Skeletal Fibers in Three Dimensional Images
Part of Medicinteknikdagarna 2007, p. 1, 2007
-
Analysis of 3D images of molecules, cells, tissues and organs
Part of Medicinteknikdagarna 2007, p. 1, 2007
-
Hardware-accelerated volume visualisation of parametrically mapped dynamic breast MRI data
Part of MICCAI 2007, p. 33-40, 2007
-
Part of Global Human Resources Forum 2007, 2007
-
Incremental Spherical Interpolation with Quadratically Varying Angle
Part of SIGRAD 2006. The Annual SIGRAD Conference, Special Theme: Computer Games, November 22–23, 2006, Skövde, Sweden, 2006
-
Finding cells, finding molecules, finding patterns
Part of Advances in Data Mining, p. 15-24, 2006
-
Possibilities in using skin texture based image registration for movement analysis
Part of Ninth International Symposium On the 3D Analysis of Human Motion, 2006
-
Automatic Tracking of Neural Stem Cells
Part of WDIC 2005, p. 61-66, 2005
-
Dynamic breast MRI visualised through colour mapping
Part of Proceedings SSBA 2005, p. 9-12, 2005
-
Visualisation of the pattern of contrast enhancement in dynamic breast MRI
Part of WDIC 2005, 2005
-
Pre-Processing of Underwater Images Taken in shallow Water for Color Reconstruction Purposes
Part of IASTED Proceeding (479), 2005
-
Dissolved Organic Matters Impact on Colour
Part of Image Analysis, p. 1148-1156, 2005
-
Computerized Cell Image Processing in Healthcare
Part of Proceedings of Healthcomm2005, p. 11-17, 2005
-
Connected Minimal Acceleration Trigonometric Curves
Part of SIGRAD 2005 The Annual SIGRAD Conference Special Theme – Mobile Graphics November 23-24, 2005 Lund, Sweden, 2005
-
Digital image processing for multiplexing of single molecule detection
Part of Medicinteknikdagarna, 2005
-
Modeling stem cell migration by Hidden Markov
Part of Proceedings of the Swedish Symposium on Image Analysis, SSBA 2004, p. 122-125, 2004
-
Time-lapse microscopy and image analysis for tracking stem cell migration
Part of Proceedings of the Swedish Symposium on Image Analysis SSBA 2004, p. 118-121, 2004
-
Haptic guided seeding of MRA images for semi-automatic segmentation
Part of Proceedings of IEEE international symposium on biomedical imaging, p. 288-291, 2004
-
Segmentation of cell nuclei in tissue by combining seeded watersheds with gradient information
Part of Proceedings of SCIA-03, p. 408-414, 2003
-
Modelling of shapes without landmarks
2003
-
Modelling non-linearities in images using an auto-associativeneural network
2003
-
Watershed techniques for segmentation in image cytometry
Part of Proceedings of the 1st International Cytomics Conference, 2003
-
Robust methods for image segmentation and measurements.
Part of Proceedings for Modern Methods for Quantitative Metallography, 2003
-
Computerized Cell Image Analysis: Past, Present and Future
2003
-
A modified Phong-Blinn light model for shadowed areas
Part of Proceedings of 3rd conference for the promotion of research in IT, 2003
-
Reconstruction Filters for Bump Mapping
Part of Proceedings from Promote IT 2002, p. 244-256, 2002
-
Statistical quality control for segmentation of fluorescence labelled cells
Part of 5th Korea-Germany Joint Workshop on Advanced Medical Image Processing, Seoul, Korea, 2001
-
Part of Proceedings of SCIA-01 (Scandinavian Conference on Image Analysis), p. 25-31, 2001
-
Multi-dimensional image analysis of sequential immunofluorescence staining
Part of 7th European Society for Analytical Cellular Pathology Congress (ESACP 2001), Caen, France, p. 61, 2001
-
Analysis of cells using image data from sequential immunofluorescence staining experiments
Part of 5th Korea-Germany Joint Workshop on Advanced Medical Image Processing, Seoul, Korea, 2001
-
Detection of large numbers of antigens using sequential immunofluorescence staining
Part of 7th European Society for Analytical Cellular Pathology Congress (ESACP 2001), Caen, France, p. 56-57, 2001
-
Automatic cytoplasm segmentation of fluorescence labelled cells
Part of Symposium on Image Analysis - SSAB 2000, p. 29-32, 2000
-
Cervical Pre-screening Using Computerized Image Analysis
Part of Proceedings of the 3rd Scandinavian Conference on Image Analysis, p. 404-411, 1983
-
Algorithms for Cluster Analysis
Part of Proceedings of the 3rd Scandinavian Conference on Image Analysis, p. 134-139, 1983
-
Object Oriented Cell Image Segmentation
Part of Proceedings of the IEEE International Symposium on Medical Imaging and Image Interpretation, p. 140-145, 1982
-
Analysing the Factors That Make Breast Cancer Recur
1982
-
Computer-assisted Scanning Microscopy in Cytology
Part of Proceedings of the IEEE International Symposium on Medical Imaging and Image Interpretation, p. 497-503, 1982
-
Factors of Prognostic Significance in Human Breast Cancer
1981
-
Bedömning av återfallsrisk vid bröstcancer
1981
-
Segmentation of Cell Images by Minimum Error Thresholding
Part of Proceedings of the 2nd Scandinavian Conference on Image Analysis, 1981