Jonas Eriksson
Visiting researcher at Department of Medicinal Chemistry; Preparative Medicinal Chemistry
- E-mail:
- jonas.eriksson@ilk.uu.se
- Visiting address:
- Uppsala Biomedicinska Centrum, BMC, Husarg. 3
- Postal address:
- Box 574
751 23 UPPSALA
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Biography
Jonas Eriksson was born in Sundsvall, Sweden in 1973. After chemistry studies at Uppsala University he completed his PhD in 2006 on the topic of 11C-chemistry for Positron Emission Tomography (PET) under the guidance of Professor Bengt Långström. He then relocated to The Netherlands and continued in the PET field with a postdoctoral position at VU University Amsterdam with Professor Bert Windhorst and was later appointed a permanent position at the PET research department at VUmc Amsterdam. In 2012 he returned to Sweden and the Uppsala University Hospital PET centre where he now works as senior researcher in radiopharmaceutical chemistry with affiliation to the Department of Medicinal Chemistry at the Uppsala University. His research interests include radiopharmaceutical chemistry, preclinical and clinical PET tracer development.
Publications
Selection of publications
- The development of 11C-carbonylation chemistry (2021)
- A comparative study on Suzuki‐type 11 C‐methylation of aromatic organoboranes performed in two reaction media (2021)
- Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain (2020)
- Synthesis of 11C-Labelled Ureas by Palladium(II)-Mediated Oxidative Carbonylation (2017)
- Imaging in-vivo tau pathology in Alzheimer's disease with THK5317 PET in a multimodal paradigm (2016)
- Low-Pressure Radical C-11-Aminocarbonylation of Alkyl Iodides through Thermal Initiation (2016)
- Transition metal mediated synthesis using [11C]CO at low pressure - a simplified method for 11C-carbonylation (2012)
Recent publications
- Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β (2024)
- Optimized method for fluorine-18 radiolabeling of Affibody molecules using RESCA (2024)
- Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion (2024)
- Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET (2024)
- Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule (2024)
All publications
Articles
- Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β (2024)
- Optimized method for fluorine-18 radiolabeling of Affibody molecules using RESCA (2024)
- Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion (2024)
- Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET (2024)
- Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule (2024)
- Antibody engagement with amyloid‐beta does not inhibit [11C]PiB binding for PET imaging (2024)
- [18F]MK-7246 for Positron Emission Tomography Imaging of the Beta-Cell Surface Marker GPR44 (2023)
- Preclinical evaluation of Affibody molecule for PET imaging of human pancreatic islets derived from stem cells. (2023)
- Imaging of fibrogenesis in the liver by [18F]TZ-Z09591, an Affibody molecule targeting platelet derived growth factor receptor β (2023)
- Synaptic density in aging mice measured by [18F]SynVesT-1 PET (2023)
- 11C-PiB and 124I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention (2022)
- P-119 - Efficient cartridge-based synthesis of a novel [18F]tetrazine for large molecule labelling (2022)
- Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody (2022)
- Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging (2022)
- PET Imaging in Preclinical Anti-Aβ Drug Development (2022)
- PET Imaging of GPR44 by Antagonist [C-11]MK-7246 in Pigs (2021)
- The development of 11C-carbonylation chemistry (2021)
- Potential of [C-11]UCB-J as a PET tracer for islets of Langerhans (2021)
- A comparative study on Suzuki‐type 11 C‐methylation of aromatic organoboranes performed in two reaction media (2021)
- In vivo imaging of synaptic density with [C-11]UCB-J PET in two mouse models of neurodegenerative disease (2021)
- Quantification of aromatase binding in the female human brain using [11 C]cetrozole positron emission tomography. (2020)
- Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain (2020)
- Synthesis and preclinical evaluation of the CRTH2 antagonist [11C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass (2019)
- Synaptic vesicle protein 2A as a potential biomarker in synaptopathies (2019)
- Optimal timing of tau pathology imaging and automatic extraction of a reference region using dynamic [18F]THK5317 PET (2019)
- Improved synthesis of SV2A targeting radiotracer [11C]UCB-J (2019)
- Palladium(0)-Catalyzed Carbonylative Synthesis of N-Acylsulfonamides via Regioselective Acylation (2019)
- [F-18]Tetrazine-trans-cyclooctene mediated labelling of antibodies for PET imaging of amyloid-beta (2018)
- Automated GMP-production of α-[11 C]methyl-L-tryptophan using a tracer production system (TPS) (2018)
- Synthesis and preliminary preclinical evaluation of fluorine-18 labelled isatin-4-(4-methoxyphenyl)-3-thiosemicarbazone ([18F]4FIMPTC) as a novel PET tracer of P-glycoprotein expression (2018)
- Synthesis of 11C-Labelled Ureas by Palladium(II)-Mediated Oxidative Carbonylation (2017)
- Low-Pressure Radical 11C-Aminocarbonylation of Alkyl Iodides through Thermal Initiation (2017)
- Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [(11)C]ABP688 PET imaging and ex vivo immunoblotting (2017)
- Combined PET and microdialysis for in vivo estimation of drug blood-brain barrier transport and brain unbound concentrations (2017)
- Quantitative assessment of synaptic density using the SV2A ligand C-11-UCBA in humans (2017)
- Parametric Methods for Dynamic (11)C-Phenytoin PET Studies. (2017)
- Synthesis and In Vitro Evaluation of 5-Substituted Benzovesamicol Analogs containing N-Substituted Amides as Potential Positron Emission Tomography Tracers for the Vesicular Acetylcholine Transporter (2017)
- Imaging in-vivo tau pathology in Alzheimer's disease with THK5317 PET in a multimodal paradigm (2016)
- Low-Pressure Radical C-11-Aminocarbonylation of Alkyl Iodides through Thermal Initiation (2016)
- Parametric Binding Images of the TSPO Ligand 18F-DPA-714. (2016)
- Synthesis of 11C-labelled Sulfonyl Carbamates via a Multicomponent Reaction Employing Sulfonyl Azides, Alcohols and [11C]CO (2016)
- In vivo (R)-[(11)C]PK11195 PET imaging of 18kDa translocator protein in recent onset psychosis. (2016)
- Synthesis of [3-N-11C-methyl]temozolomide via in situ activation of 3-N-hydroxymethyl temozolomide and alkylation with [11C]methyl iodide (2015)
- Quantification of [18F]DPA-714 binding in the human brain (2015)
- Visualization of regional tau deposits using (3)H-THK5117 in Alzheimer brain tissue (2015)
- A Comparative Study of the Hypoxia PET Tracers [(18)F]HX4, [(18)F]FAZA, and [(18)F]FMISO in a Preclinical Tumor Model. (2015)
- [18F]VM4-037 MicroPET Imaging and Biodistribution of Two In Vivo CAIX-Expressing Tumor Models (2015)
- (R)-[(11)C]PK11195 brain uptake as a biomarker of inflammation and antiepileptic drug resistance (2014)
- Strategy to develop a MAO-A-resistant 5-hydroxy-L-[beta-C-11]tryptophan isotopologue based on deuterium kinetic isotope effects (2014)
- Molecular Imaging of Inflammation Reveals Differences Between Drug-Resistant and Drug-Sensitive Animals in a Chronic Model of Temporal Lobe Epilepsy (2014)
- In Vivo Quantification of Hypoxic and Metabolic Status of NSCLC Tumors Using [18F]HX4 and [18F]FDG-PET/CT Imaging. (2014)
- Automation of the 'xenon method' and comparative study on C-11-carbonylation at ambient pressure versus high solvent pressure (2013)
- [(11)C]Sorafenib: Radiosynthesis and preclinical evaluation in tumor-bearing mice of a new TKI-PET tracer. (2013)
- Radiation Dose of the P-Glycoprotein Tracer 11C-Laniquidar. (2013)
- Advances in PET Imaging of P-Glycoprotein Function at the Blood-Brain Barrier. (2013)
- [C-11]quinidine and [C-11]laniquidar PET imaging in a chronic rodent epilepsy model (2013)
- Toward Prediction of Efficacy of Chemotherapy (2013)
- Hypoxia imaging with [(18)F]HX4 PET in NSCLC patients (2013)
- Transition metal mediated synthesis using [11C]CO at low pressure - a simplified method for 11C-carbonylation (2012)
- [11C]Flumazenil brain uptake is influenced by the blood-brain barrier efflux transporter P-glycoprotein. (2012)
- Dual-Phase PET-CT to Differentiate [(18)F]Fluoromethylcholine Uptake in Reactive and Malignant Lymph Nodes in Patients with Prostate Cancer (2012)
- Altered GABAA Receptor Density and Unaltered Blood-Brain Barrier Transport in a Kainate Model of Epilepsy (2012)
- Blood-brain barrier P-glycoprotein function in healthy subjects and Alzheimer's disease patients (2012)
- Towards Prediction of Efficacy of Chemotherapy (2012)
- Rapid Decrease in Delivery of Chemotherapy to Tumors after Anti-VEGF Therapy (2012)
- [11C]phenytoin revisited (2012)
- Synthesis and preclinical evaluation of [11C]D617, a metabolite of (R)-[11C]verapamil. (2012)
- Synthesis of [11C]/[13C]acrylamides by palladium-mediated carbonylation (2007)
- Synthesis of two potential NK1-receptor ligands using [1-11C]ethyl iodide and [1-11C]propyl iodide and initial PET-imaging (2007)
- Synthesis of [1-C-11]propyl and [1-C-11]butyl iodide from [C-11]carbon monoxide and their use in alkylation reactions (2006)
- [C-11]methyl iodide from [C-11]methane and iodine using a non-thermal plasma method (2006)
- The Effect of Solvent on the Structure of the Transition State for the SN2 Reaction between Cyanide Ion and Ethyl Chloride in DMSO and THF Probed with Six Different Kinetic Isotope Effects (2006)
- Synthesis of [1-11C]ethyl iodide from carbon monoxide and its application in alkylation reactions (2004)
- Experimental and Theoretical Multiple Kinetic Isotope Effects for an SN2 Reaction. An Attempt to Determine Transition-State Structure and the Ability of Theoretical Methods to Predict Experimental Kinetic Isotope Effects (2003)
- Preclinical evaluation of Affibody molecule 18F-TZ-ZAM106 for PET imaging of DGCR2
- Single domain antibody conjugated to Aβ-binding scFv penetrates BBB via TfR to interact with Aβ
- Synthesis and Preclinical Evaluation of GRPR Antagonist [18F]-MeTz-PEG2-RM26 for Position Emission Tomography
- Transgenic mice harboring the Uppsala APP mutation display altered APP processing and accelerated Aβ42 pathology with distinct structural features
- Aβ targeting ImmunoPET
- [1-11C]Ethyl iodide and [1-11C]propyl iodide in the synthesis of two potential NK1-receptor ligands and initial PET-imaging
- [11C]PiB binding after treatment with an amyloid-beta antibody
- Synaptic density in aging mice measured by [18F]SynVesT-1 PET